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1.
Water Sci Technol ; 82(11): 2259-2270, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33339782

RESUMO

The goal of the present study is to treat industrial wastewater containing sodium aluminate using a chemically inert polyurea (PU) based thin film composite (TFC) reverse osmosis (RO) membrane to promote water reclamation and zero liquid discharge (ZLD). Pretreatment was carried out to reduce the pH of the effluent from 12.5 to 7.1. The TFC RO membrane was fabricated by coating PU on Polyethersulfone (PES) substrate by interfacial polymerization (IP). The surface and cross-sectional morphologies of the membrane were characterized using scanning electron microscopy (SEM). The indigenously synthesized membrane was effective in the removal of total dissolved solids (TDS), chemical oxygen demand (COD), colour and electrical conductivity. The experiments were conducted by varying the feed composition of the wastewater. The maximum water recovery and flux were found to be 74% and 73.9 L/m2·h. RO process using PU membrane exhibited significant potential for cost effective, safe and pollution-free treatment of sodium aluminate industrial effluent.


Assuntos
Águas Residuárias , Purificação da Água , Compostos de Alumínio , Estudos Transversais , Membranas Artificiais , Osmose , Polímeros , Compostos de Sódio
2.
Braz Dent J ; 31(5): 477-484, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33146330

RESUMO

This study evaluated the biocompatibility, biomineralization, and collagen fiber maturation induced by Resorbable Tissue Replacement (RTR®; ß-tricalcium phosphate [TCP]), Bioglass (BIOG; bioactive glass), and DM Bone® (DMB; hydroxyapatite and ß-TCP) in vivo. Sixty-four polyethylene tubes with or without (control group; CG) materials (n=8/group/period) were randomly implanted in the subcutaneous tissue of 16 male Wistar rats (four per rat), weighting 250 to 280 g. The rats were killed after 7 and 30 days (n=8), and the specimens were removed for analysis of inflammation using hematoxylin-eosin; biomineralization assay using von Kossa (VK) staining and polarized light (PL); and collagen fiber maturation using picrosirius red (PSR). Nonparametric data were statistically analyzed by Kruskal-Wallis and Dunn tests, and parametric data by one-way ANOVA test (p<0.05). At 7 days, all groups induced moderate inflammation (p>0.05). At 30 days, there was mild inflammation in the BIOG and CG, and moderate inflammation in the RTR and DMB groups, with a significant difference between the CG and RTR (p<0.05). The fibrous capsule was thick at 7 days and predominantly thin at 30 days in all groups. All materials exhibited structures that stained positively for VK and PL. Immature collagen fibers were predominant at 7 and 30 days in all groups (p>0.05), although DMB exhibited more mature fibers than BIOG at 30 days (p<0.05). RTR, BIOG, and DMB were biocompatible, inducing inflammation that reduced over time and biomineralization in the subcutaneous tissue of rats. DMB exhibited more mature collagen fibers than BIOG over a longer period.


Assuntos
Biomineralização , Materiais Restauradores do Canal Radicular , Compostos de Alumínio , Animais , Materiais Biocompatíveis , Compostos de Cálcio , Cerâmica , Colágeno , Masculino , Teste de Materiais , Óxidos , Ratos , Ratos Wistar , Silicatos , Tela Subcutânea
3.
Braz Dent J ; 31(5): 511-515, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33146335

RESUMO

This study aimed to assess the physicochemical properties of a repair material in the Brazilian market, BioMTA, in comparison to other two materials currently in use (Biodentine and MTA Angelus). The initial setting time was evaluated using Gillmore needle. The pH was measured with a pH-meter after 24 h, 3, 7, 14 and 21 days. The radiopacity was determined using the equivalence in millimeters of aluminum (mm Al) from digitized occlusal radiographs. Solubility was determined after immersion in water for 7 days. The data were analyzed by one-way ANOVA and Tukey tests (a=0.05). The BioMTA initial setting time (5.2 min) was lower than the other materials (p<0.05). All materials showed an alkaline pH at 21 days. At 24 h, BioMTA was the most alkaline material (p<0.05); and at 3, 7, 14 and 21 days there was no difference between BioMTA and Biodentine (p>0.05), both being more alkaline than MTA Angelus (p<0.05). The radiopacity of BioMTA (4.2 mm Al) was significantly higher compared to Biodentine (p<0.05) and lower than MTA Angelus (p<0.05). The solubility of the materials was -4.2%, -1.6% and 4.1% for BioMTA, MTA Angelus and Biodentine, respectively, with a significant difference between them (p<0.05). Therefore, it can be concluded that BioMTA displayed a shorter setting time, an alkaline pH, a higher radiopacity, and a gain in mass.


Assuntos
Materiais Restauradores do Canal Radicular , Silicatos , Resinas Acrílicas , Compostos de Alumínio , Brasil , Compostos de Cálcio , Combinação de Medicamentos , Teste de Materiais , Óxidos , Solubilidade , Água
4.
J Contemp Dent Pract ; 21(7): 760-764, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-33020359

RESUMO

AIM: One of the most vital characteristics of an ideal root filling material is the capability to inhibit the growth of the microorganisms. Mineral trioxide aggregate (MTA) is one of the most used root repair materials, with approved antibacterial effect. A newly introduced root repair material is nano-fast cement (NFC) which should be investigated. The antibacterial and antifungal activities of NFC were evaluated in the present study. MATERIALS AND METHODS: Enterococcus faecalis (PTCC 1394), Escherichia coli (ATTC 15224), and Candida albicans (PTCC 5027) were employed for the antimicrobial assessment. The following were the steps used to conduct the agar diffusion test (ADT): six agar plates were used. 0.5 McFarland concentration of each strain was cultured on two plates by a sterile cotton-tipped swab. Three holes with 5mm diameter were created on each plate. Freshly mixed cement was placed in the holes of the related plate. After two hours, the plates were incubated at 37°C for 24 hours. Then, the diameter of the growth inhibition zones were measured, and the mean values were used for the analysis. Direct contact test (DCT) was done by using the following steps: Freshly mixed materials were placed in the 96-well microtiter plate. 10 µL of each bacterial suspension was added to the tested cement. After one-hour incubation at 37°C, 245 µL of BHI broth was added to each well, and the plate was vortexed for 2 minutes. About 15 µL of this bacterial suspension was added to a new well which contained 215 µL of fresh medium. The kinetics of the bacterial outgrowth were measured by the microplate spectrophotometer hourly for 12 hours. RESULTS: No significant differences were observed between the diameters of the growth inhibition zones of MTA and NFC groups in ADT. In DCT, the MTA inhibits E. coli more effectively than NFC (p value < 0.001). Both cements had the same inhibitory effect on E. faecalis and C. albicans. CONCLUSION: The MTA and NFC are almost equally effective against the tested microorganisms. CLINICAL SIGNIFICANCE: The antibacterial characteristic of any dental material is an important matter. As well, the antibacterial efficacy of the NFC should be evaluated.


Assuntos
Antifúngicos/farmacologia , Escherichia coli , Compostos de Alumínio , Antibacterianos/farmacologia , Compostos de Cálcio , Combinação de Medicamentos , Óxidos , Materiais Restauradores do Canal Radicular , Silicatos
5.
Braz Oral Res ; 34: e102, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32876119

RESUMO

The aim of this study was to evaluate and compare the clinical and radiographic success rates of pulpotomies in primary molars using a new stain-free tricalcium silicate cement (Bio-C Pulpo) versus a conventional white MTA (MTA Angelus) as a pulpotomy medicament for primary teeth. Seventy primary teeth in 33 patients were randomly divided into two groups, MTA Angelus (n = 34) and Bio-C Pulpo (n = 36). Clinical and radiographic follow-up examinations were conducted at seven days (except radiographic follow-up), and at one, three, six and 12 months. At 12 months, the clinical success rate of the MTA Angelus group was 100 percent (28 out of 28), and the radiographic success rate was 100 percent (28 out of 28). In comparison, the clinical success rate for the Bio-C Pulpo group was 100 percent (29 out of 29), and the radiographic success rate was 100 percent (29 out of 29). No significant differences were found between the groups at any follow-up evaluation. According to Fisher´s exact test, a significant difference was observed between the pulpotomy agent and tooth discoloration (p < 0.001). The success rates were 100% for the Bio-C Pulpo group, with no case of discoloration, and 10.31% for the MTA Angelus group. Both MTA Angelus and Bio-C Pulp pulpotomy medicaments are appropriate options for pulpotomies in primary teeth, and enable high clinical and radiographic success rates. However, more long-term studies are required to test the new Bio-C Pulpo medicament.


Assuntos
Pulpotomia , Compostos de Alumínio , Compostos de Cálcio , Cimentos Dentários , Combinação de Medicamentos , Humanos , Óxidos , Silicatos , Dente Decíduo , Resultado do Tratamento
6.
Braz Dent J ; 31(4): 385-391, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32901714

RESUMO

The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV). Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV. The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0). The morphology and composition of the scaffolds were evaluated by SEM and EDS, respectively. After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed. Calcium aluminate particles were incorporated into the chitosan matrix, which exhibited regular pores homogeneously distributed throughout its structure. The selected SV dosages were biocompatible with HDPCs. Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression. Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.


Assuntos
Quitosana , Compostos de Alumínio , Cálcio , Compostos de Cálcio , Humanos , Porosidade , Sinvastatina
7.
Eur J Paediatr Dent ; 21(3): 238-242, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32893659

RESUMO

BACKGROUND: Molar Incisor Malformation (MIM) or Molar Root Incisor malformation (MRIM) is a recently discovered root malformation with constricted pulp and abnormally located furcation presented in permanent first molars and sometimes incisors. CASE REPORT: Two cases that feature MIM are presented with the description of the characteristic tooth form, clinical/radiographic examination, medical history, the supposed aetiology, treatment procedure and results at the 2-year follow-up. Conservative endodontic treatment was performed in both cases, furcation perforation and canal perforation were filled with MTA (Mineral Trioxide Aggregate), and a good prognosis was observed after 2 years of follow-up. Furthermore, recommended treatment options are discussed to provide a more appropriate treatment for the patients. CONCLUSION: Patients with MIM need to be treated at the right time to avoid severe infection and other problems. Early diagnosis with appropriate treatment is more likely to lead to a more favourable prognosis.


Assuntos
Incisivo , Materiais Restauradores do Canal Radicular , Compostos de Alumínio , Compostos de Cálcio , Polpa Dentária , Cavidade Pulpar , Combinação de Medicamentos , Humanos , Dente Molar , Óxidos , Silicatos , Raiz Dentária
8.
J Endod ; 46(12): 1913-1919, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32949559

RESUMO

INTRODUCTION: New tricalcium silicate cements have been shown to induce less coronal discoloration. The purpose of this in vitro study was to evaluate the degree of color change induced by various silicate materials in the presence and absence of blood. METHODS: One hundred human extracted anterior single-canal teeth were sectioned to standardized root lengths, accessed, and instrumented. Eight random experimental groups and 2 control groups were created wherein specimens were filled with experimental materials below the buccal cementoenamel junction as follows: EndoSequence RRM putty (Brasseler USA, Savannah, GA), EndoSequence RRM fast set putty (Brasseler USA), Biodentine (Septodont, Saint-Maur-des-Fossés, France), and white mineral trioxide aggregate (Dentsply Sirona, York, PA) either with the presence or absence of blood. Blood-only and saline-only samples were used for the positive and negative controls. After incubation in 100% humidity at 37°C, color changes were evaluated with a spectrophotometer (Ocean Optics, Dunedin, FL) on days 0, 30, 60, and 180 after material placement. Data were transformed into Commission International de I'Eclairage's L∗a∗b color values, and corresponding ΔE values were calculated. The 1-way analysis of variance test was performed for statistical analysis. RESULTS: Discoloration was observed in all specimens in the presence of blood. There was no statistical significance when comparing different materials in contact with blood. Intragroup observation at various time points, Biodentine, and EndoSequence RRM fast set putty showed significant difference between the presence and absence of blood at 180 days (P < .05). CONCLUSIONS: Contamination with blood of tricalcium silicate materials has the potential to cause coronal tooth discoloration.


Assuntos
Materiais Restauradores do Canal Radicular , Descoloração de Dente , Dente , Compostos de Alumínio , Compostos de Cálcio/efeitos adversos , Combinação de Medicamentos , França , Humanos , Óxidos , Materiais Restauradores do Canal Radicular/efeitos adversos , Silicatos/efeitos adversos , Descoloração de Dente/induzido quimicamente
9.
J Appl Oral Sci ; 28: e20200033, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32785523

RESUMO

Aim To evaluate the cytotoxicity, biocompatibility and mineralization capacity of BIO-C PULPO, and MTA. Methodology L929 fibroblasts were cultured and MTT assay was used to determine the material cytotoxicity on 6, 24, and 48 h. A total of 30 male rats (Wistar) aged between 4 and 6 months, weighing between 250 and 300 g were used. Polyethylene tubes containing BIO-C PULPO, MTA, and empty tubes were implanted into dorsal connective tissue. After the experimental periods (7, 15, 30, 60, and 90 days) the tubes were histologically analyzed using hematoxylin-eosin (H&E), immunolabeling of IL-1ß and TNF-α, and von Kossa staining, or without staining for polarized light analysis. The average number of inflammatory cells was quantified; the mineralization assessment was determined by the area marked in µm2 and semiquantitative immunolabeling analyses of IL-1ß and TNF-α were performed. Then, data underwent statistical analysis with a 5% significance level. Results It was observed that BIO-C PULPO and MTA presented cytocompatibility at 6, 24, and 48 similar or higher than control for all evaluated period. On periods 7 and 15 days, BIO-C PULPO was the material with the highest number of inflammatory cells (p<0.05). On periods 30, 60, and 90 days, BIO-C PULPO and MTA presented similar inflammatory reactions (p>0.05). No statistical differences were found between Control, BIO-C PULPO, and MTA for immunolabeling of IL-1ß and TNF-α in the different periods of analysis (p<0.05). Positive von Kossa staining and birefringent structures under polarized light were observed in all analyzed periods in contact with both materials, but larger mineralization area was found with BIO-C PULPO on day 90 (p<0.05). Conclusion BIO-C PULPO was biocompatible and induced mineralization similar to MTA.


Assuntos
Biomineralização , Cimentos Dentários , Interleucina-1beta/metabolismo , Materiais Restauradores do Canal Radicular , Fator de Necrose Tumoral alfa/metabolismo , Compostos de Alumínio , Animais , Materiais Biocompatíveis , Compostos de Cálcio , Combinação de Medicamentos , Inflamação , Masculino , Óxidos , Ratos , Ratos Wistar , Silicatos , Tela Subcutânea
10.
Bioresour Technol ; 316: 123950, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32795867

RESUMO

For the first time, using aluminum-boron electrodes in the electrocoagulation cell for harvesting the cultivated Chlorella microalgae and then performing a hydrothermal process of producing biofuel, mesoporous biochar was produced with an average pore diameter of 11.62 nm, a high specific surface area of 126.4 m2/g and a total pore volume of 0.55 cm3/g. Based on the chemical characterization, aluminum boride carbide (Al3B48C2) and boehmite [Al2(OOH)2] were identified in the biochar composition so that 7.17 wt% Al and 16.67 wt% B were measured on the biochar surface by EDS analysis. As the by-product of hydrothermal converting microalgae Chlorella into biofuel, the residual biochar was innovatively used to separate tetracycline from aqueous solutions. The nonlinear form of the Freundlich model fitted theadsorption equilibrium data well with the least error function value explained by the intraparticle diffusion model. The maximum adsorption capacity of 25.94 mg/g was obtained through endothermic physical adsorption.


Assuntos
Chlorella , Poluentes Químicos da Água/análise , Adsorção , Alumínio , Compostos de Alumínio , Hidróxido de Alumínio , Óxido de Alumínio , Compostos de Boro , Carvão Vegetal , Cinética , Tetraciclina/análise
11.
J Environ Manage ; 271: 110986, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32778279

RESUMO

As the disposal of phosphogypsum can result in severe contamination of soil and groundwater, several researchers worldwide have devoted efforts toward realizing suitable methods for PG disposal. This study demonstrates the feasibility of using phosphogypsum as the sole CaO source in the preparation of calcium sulfoaluminate cement by considering its mechanical properties and the potential environmental impacts of its large-scale utilization. First, the effects of the alumina/silica ratio on the mineral phase formation, setting time, compressive strength, and microstructure of calcium sulfoaluminate cement were studied. An alumina/silica ratio of 2.0 or 2.5 resulted in satisfactory mineral phase formation and compressive strength; the compressive strength of calcium sulfoaluminate cement reached 63.2, 88.5, and 100.2 MPa after 1, 3, and 28 d of curing, respectively. Second, the environmental behaviors of harmful impurities in the raw materials and calcium sulfoaluminate cement were investigated. In the static leaching and acid leaching tests, the concentrations of harmful elements in the calcium sulfoaluminate cement leachates met the requirements of national standards (GB/T14848-2007). After a period of curing, P and some heavy metals (Mn, Cr, Ni, Cu, and As) did not leach from the cement. Finally, a novel process and a system of preparing CSA cement by using phosphogypsum as the sole CaO source are proposed. This novel technology could be employed as a reliable and environment friendly means of recycling phosphogypsum in the large-scale preparation of calcium sulfoaluminate cement.


Assuntos
Compostos de Alumínio , Compostos de Cálcio , Sulfato de Cálcio , Óxidos , Fósforo , Compostos de Enxofre
12.
Niger J Clin Pract ; 23(8): 1068-1072, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32788483

RESUMO

Aims: The aim of this study was to compare the influence of operators on the microhardness and compressive strength of mineral trioxide aggregate (MTA). Materials and Methods: Forty dental specialists were asked to prepare a series of MTA samples. The tested material was ProRoot MTA (DentsplyMaillefer, Switzerland). Each participant prepared one sample to a consistency they considered acceptable for use in practice (improvised group) and another one according to the manufacturer's recommended water-to-powder (WP) ratio (pre-weighed group). The samples were incubated at 37°C and 95% humidity for 4 days. Parameters evaluated in this study were microhardness and compressive strength. Results: Operators mixed MTA samples with varying WP ratios. However, there was no significant difference between the microhardness and compressive strength values of MTA samples between the improvised, the pre-weighed and the control groups. MTA was mixed in a thicker consistency than the manufacturers recommended ratio (0.33) by 62.5% of the operators. Conclusion: According to the results of this study, even though the WP ratios that were utilized in the clinical setting vary, microhardness and compressive strength values of MTA was not significantly affected.


Assuntos
Compostos de Alumínio/química , Compostos de Cálcio/química , Força Compressiva , Teste de Materiais/métodos , Óxidos/química , Materiais Restauradores do Canal Radicular , Silicatos/química , Estudos de Casos e Controles , Combinação de Medicamentos , Dureza , Humanos , Água
13.
J Vis Exp ; (160)2020 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-32658181

RESUMO

This protocol demonstrates a method for graphene-assisted quick growth and coalescence of AlN on nano-pattened sapphire substrate (NPSS). Graphene layers are directly grown on NPSS using catalyst-free atmospheric-pressure chemical vapor deposition (APCVD). By applying nitrogen reactive ion etching (RIE) plasma treatment, defects are introduced into the graphene film to enhance chemical reactivity. During metal-organic chemical vapor deposition (MOCVD) growth of AlN, this N-plasma treated graphene buffer enables AlN quick growth, and coalescence on NPSS is confirmed by cross-sectional scanning electron microscopy (SEM). The high quality of AlN on graphene-NPSS is then evaluated by X-ray rocking curves (XRCs) with narrow (0002) and (10-12) full width at half-maximum (FWHM) as 267.2 arcsec and 503.4 arcsec, respectively. Compared to bare NPSS, AlN growth on graphene-NPSS shows significant reduction of residual stress from 0.87 GPa to 0.25 Gpa, based on Raman measurements. Followed by AlGaN multiple quantum wells (MQWS) growth on graphene-NPSS, AlGaN-based deep ultraviolet light-emitting-diodes (DUV LEDs) are fabricated. The fabricated DUV-LEDs also demonstrate obvious, enhanced luminescence performance. This work provides a new solution for the growth of high quality AlN and fabrication of high performance DUV-LEDs using a shorter process and less costs.


Assuntos
Óxido de Alumínio/química , Grafite/química , Nanoestruturas/química , Semicondutores , Raios Ultravioleta , Compostos de Alumínio/química , Catálise , Gálio/química , Gases/química , Luminescência , Volatilização
14.
Braz Dent J ; 31(3): 252-256, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32667514

RESUMO

The purpose of this study was to investigate and to compare the physical-mechanical properties of a resin-modified calcium silicate material (TheraCal LC), used for pulp-capping, to MTA (Angelus) and a calcium hydroxide cement (Dycal). Specimens of each material (n=12) were prepared in Teflon molds (3.58 mm x 3 mm) and measured before and after immersion in distilled water for 24 h and 30 days to evaluate the dimensional change. The same specimens were submitted to compressive strength test on a Universal Testing Machine (Instron) (1 mm/min). Root canals were filled with the cements (n=8), and after 24 h, the bond strength (push-out test) to dentin was also assessed on a Universal Testing Machine (1 mm/min). Eight additional specimens of TheraCal LC were prepared to evaluate the bond strength immediately after light curing. Data were analyzed using One-Way ANOVA, and Tukey or Bonferroni post hoc tests (p<0.05). Percentage expansion of TheraCal LC was above the Specification No. 57 of ANSI/ADA, in both periods. The dimensional change for TheraCal LC was higher than MTA in 24 h and 30 days; and Dycal in 30 days (p<0.05). TheraCal LC had higher compressive and bond strength to dentin in comparison with MTA and Dycal (p<0.05). Although TheraCal LC expanded more than the ANSI/ADA recommendation, its compressive and push-out bond strength to dentin were satisfactory and superior to MTA and Dycal.


Assuntos
Capeamento da Polpa Dentária , Agentes de Capeamento da Polpa Dentária e Pulpectomia , Compostos de Alumínio , Compostos de Cálcio , Combinação de Medicamentos , Teste de Materiais , Óxidos , Silicatos
15.
J Endod ; 46(10): 1455-1464, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32668309

RESUMO

INTRODUCTION: The aim of this study was to investigate whether mineral trioxide aggregate (MTA) can be modified with caffeic acid (CA) to form caffeic acid/mineral trioxide aggregate (CAMTA) cement and to evaluate its physicochemical and biological properties as well as its capability in immune suppression and angiogenesis. METHODS: MTA was immersed in trishydroxymethyl aminomethane buffer with CA to allow coating onto MTA powders. X-ray diffractometry and tensile stress-strain tests were conducted to assess for physical characteristics of CAMTA and to evaluate for successful modification of MTA. Then, the CAMTA cement was immersed in simulated body fluid to evaluate its hydroxyapatite formation capabilities and Si release profiles. In addition, RAW 264.7 cells and human dental pulp stem cells were used to evaluate CAMTA's immunosuppressive capabilities and cell responses, respectively. hDPSCs were also used to assess CAMTA's angiogenic capabilities. RESULTS: The X-ray diffractometry results showed that CA can be successfully coated onto MTA without disrupting or losing MTA's original structural properties, thus allowing us to retain the initial advantages of MTA. CAMTA was shown to have higher mechanical properties compared with MTA and had rougher pitted surfaces, which were hypothesized to lead to enhanced adhesion, proliferation, and secretion of angiogenic- and odontogenic-related proteins. In addition, it was found that CAMTA was able to enhance hydroxyapatite formation and immunosuppressive capabilities compared with MTA. CONCLUSIONS: CAMTA cements were found to have improved physicochemical and biological characteristics compared with their counterpart. In addition, CAMTA cements had enhanced odontogenic, angiogenic, and immunosuppressive properties compared with MTA. All of the results of this study proved that CAMTA cements could be a biomaterial for future clinical applications and tissue engineering use.


Assuntos
Polpa Dentária , Materiais Restauradores do Canal Radicular/farmacologia , Compostos de Alumínio , Ácidos Cafeicos , Compostos de Cálcio/farmacologia , Cimentos Dentários , Combinação de Medicamentos , Humanos , Odontogênese , Óxidos/farmacologia , Silicatos/farmacologia
16.
Pain Res Manag ; 2020: 5853412, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32676136

RESUMO

This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (n = 188), PCEM (n = 194), or RCT (n = 168) arms. Preoperative "Pain Intensity" (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. Patients' demographic and pre-/intra-/postoperative factors/conditions were recorded/analysed. The arms were homogeneous in terms of demographics. The mean preoperative PIs were similar (P=0.998), the mean sum PIs recorded during 10 postoperative intervals were comparable (P=0.939), and the trend/changes in pain relief were parallel (P=0.821) in all study arms. The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (P=0.578). The time span of endodontic procedures was statistically different; RCT = 69.73, PMTA = 35.37, and PCEM = 33.62 minutes (P < 0.001). Patients with greater preoperative pain, symptomatic apical periodontitis, or presence of PDL widening suffered more pain (P=0.002, 0.035, and 0.023, resp.); however, other pre-/intra-/postoperative factors/conditions were comparable. Pulpotomy with MTA/CEM and RCT demonstrate comparable and effective postoperative pain relief.


Assuntos
Dor Pós-Operatória/etiologia , Pulpotomia/métodos , Materiais Restauradores do Canal Radicular/uso terapêutico , Tratamento do Canal Radicular/métodos , Adulto , Compostos de Alumínio/uso terapêutico , Compostos de Cálcio/uso terapêutico , Cimentos Dentários/uso terapêutico , Combinação de Medicamentos , Feminino , Humanos , Masculino , Dente Molar , Óxidos/uso terapêutico , Dor Pós-Operatória/epidemiologia , Prevalência , Pulpotomia/efeitos adversos , Tratamento do Canal Radicular/efeitos adversos , Silicatos/uso terapêutico , Resultado do Tratamento
17.
J Clin Pediatr Dent ; 44(3): 142-147, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32644897

RESUMO

Introduction: Bioceramic materials, gray and white mineral trioxide aggregate (GMTA, WMTA), have been shown to have high rates of success in various endodontic applications. A major drawback is their tendency to discolor teeth. Biodentine (BD), a recenlty developed bioceramic material, has been claimed not to discolor teeth. The aim of this study was to compare tooth discoloration after applying different pulpotomy base materials (BD, GMTA and WMTA). Methods: Forty human fully developed primary incisors teeth were used in this study. Coronal access was achieved by a Tungsten Carbide drill, and the pulp chambers were accessed and chemo-mechanically debrided. Each material was placed in the pulp chamber, up to the cervical sectioning level. All specimens were incubated at 37°C and 100% humidity for 14 weeks and have been evaluated before the study and weekly. Color was assessed according to the CIE L*a*b* color space system. Results: The ΔE (delta E) of all experimental groups (GMTA, WMTA and BD) were significantly different from the control group at all time points. Color changes in the GMTA and WMTA groups showed significantly higher discoloration compared to BD group in the cervical part of the crown, since week 1. WMTA group showed significant discoloration in the cervical part as of week 1, and gradually increased over time. BD group showed no significant discoloration over time. GMTA group showed the most significant discoloration at week 1 and week 14 (P<0.05). Conclusions: both GMTA and WMTA pulpotomy materials may discolor tooth structure over time in an extracted primary anterior tooth model. When choosing bioceramic pulpotomy material, BD may be preferable, mainly in esthetic area.


Assuntos
Materiais Restauradores do Canal Radicular , Descoloração de Dente , Compostos de Alumínio , Compostos de Cálcio , Combinação de Medicamentos , Estética Dentária , Humanos , Óxidos , Pulpotomia , Silicatos , Coroa do Dente , Dente Decíduo
18.
J Indian Soc Pedod Prev Dent ; 38(2): 132-137, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32611858

RESUMO

Background: Apical plug formation by mineral trioxide aggregate (MTA), Biodentine, and EndoSequence root repair material (RRM) is an excellent alternative technique to the conventional apexification procedure. Several antimicrobial agents have been incorporated in MTA and Biodentine to boost their antimicrobial efficacy. Considering the polymicrobial nature of root canal infection, a combination of potent antimicrobials like triple antibiotic powder (TAP) would be needed to address the diverse flora encountered. Calcium release is the consequential factor in the clinical excellence of these cements. Aim: The aim of the study was to evaluate and compare the calcium released from the apical plugs formed by MTA, Biodentine, and EndoSequence RRM with and without incorporation of 2% TAP. Methods: Ninety single-rooted teeth were divided into (n = 15) Group A: MTA + 2% TAP, Group B: MTA, Group C: Biodentine + 2% TAP, Group D: Biodentine, Group E: EndoSequence RRM + 2% TAP, and Group F: EndoSequence RRM to form the 4 mm apical plugs. Each sample tooth was then immersed in 10 ml of deionized water. Evaluation of calcium release was done on days 7, 15, and 30 using an atomic absorption spectrophotometer. Data were analyzed using one-way analysis of variance, post hoc test, and unpaired t-test. Results: Calcium released was maximum for Group E compared to Group F (P < 0.05), maximum for Group C compared to Group D, and was maximum for Group A compared to Group B (P < 0.05) at days 7, 15 and 30. Conclusion: Incorporation of 2% TAP resulted in increased calcium ions released from MTA, Biodentine, and EndoSequence RRM.


Assuntos
Cálcio , Materiais Restauradores do Canal Radicular , Compostos de Alumínio , Antibacterianos , Compostos de Cálcio , Fosfatos de Cálcio , Combinação de Medicamentos , Óxidos , Silicatos
19.
Orv Hetil ; 161(30): 1260-1265, 2020 07.
Artigo em Húngaro | MEDLINE | ID: mdl-32653869

RESUMO

Surgical guides and three-dimensional (3D) planning softwares used in everyday dental implantology open new possibilities in other fields of dentistry. While using the operation microscope in endodontic microsurgery provides more precise apicectomy, there is still no consent on the exact localisation and size of the bony window to be prepared for this surgery. Our aim is to describe a new, guided endodontic microsurgery method when osteotomy and apicectomy are planned in a 3D software and performed with a trephine bur. Based on data from Cone Beam Computed Tomography, planning of the surgical guide was performed with a 3D planning software (Smart Guide, dicomLAB, Hungary) in order to define the size of the bony window, the angulation and the depth of the trephine bur during the apicectomy. After preparing a mucoperiosteal flap, with the help of the dentally supported surgical guide, the trephine bur removes the cortical bone and the apex of the root simultaniously. Following the modern microsurgical protocol, after performing the ultrasonic retrograde preparation, mineral trioxide aggregate (ProRoot MTA; Dentsply Maillefer, Ballaigues, Switzerland) is placed as a retrograde filling to close the resected area. After the uneventful healing period, a complete bony regeneration can be seen on the 1-year follow up X-ray. The patient is symptom-free. This technique is considered to be faster and more precise than the non-guided endodontic microsurgery carried out without the utilization of a trephine bur. Orv Hetil. 2020; 161(30): 1260-1265.


Assuntos
Apicectomia/métodos , Tomografia Computadorizada de Feixe Cônico/métodos , Cavidade Pulpar/cirurgia , Endodontia/métodos , Microcirurgia/métodos , Osteotomia/métodos , Impressão Tridimensional , Materiais Restauradores do Canal Radicular , Tratamento do Canal Radicular/métodos , Compostos de Alumínio , Compostos de Cálcio , Cavidade Pulpar/diagnóstico por imagem , Combinação de Medicamentos , Humanos , Hungria , Óxidos , Radiografia Dentária , Silicatos , Dente , Resultado do Tratamento , Procedimentos Cirúrgicos Ultrassônicos
20.
J Oleo Sci ; 69(7): 771-782, 2020 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-32522946

RESUMO

The role of fish oil, primrose oil and their mixture in ameliorating the changes in Alzheimer's like model was evaluated in rats. Primrose oil and primrose/fish oil mixture fatty acids composition was assessed by gas chromatography. The rat experiment consisted of 5 groups; the first fed on balanced diet as control normal (CN); the other four groups treated with intraperitoneal aluminum lactate and consumed dyslipidemic diet; one group served as control Alzheimer's like disease (CA) while the other three groups (test groups) received daily oral dose from primrose oil, fish oil and primrose/fish oil mixture separately for 5 weeks. Results showed primrose oil and primrose/ fish oil mixture to contain gamma linolenic acid as 9.15 and 4.3% of total fatty acids, respectively. Eicosapentaenoic and docosahexaenoic were present as 10.9 and 6.5 %, respectively in the oil mixture. Dyslipidemia and increased erythrocyte sedimentation rate (ESR), plasma butyrylcholinesterase (BChE), brain malondialdehyde (MDA) and NO with decrease in plasma magnesium, brain catalase, reduced glutathione, body weight gain and brain weight were demonstrated in CA compared to CN. Brain histopathology and immuno-histochemistry showed neuronal degeneration and neurofibrillary tangles with elevated myeloperoxidase and nuclear factor-kappa B in CA compared to CN. The tested oils demonstrated neuro-protection reflected in the variable significant improvement of biochemical parameters, immuno-histochemistry and brain histopathology. Primrose/fish oil mixture was superior in reducing ESR, brain MDA, plasma activity of BChE and brain histopathological changes along with elevating plasma magnesium. Primrose/fish oil mixture and fish oil were more promising in improving plasma high density lipoprotein cholesterol (HDL-C) than primrose. Fish oil was the most efficient in improving plasma total cholesterol (T-C), low density lipoprotein cholesterol and T-C /HDL-C. Primrose/fish oil mixture and primrose oil were superior in elevating brain catalase compared to fish oil. Other parameters were equally improved by the different oil treatments. Primrose oil, fish oil and their mixture reduced the progression of Alzheimer's disease in rats with superiority to primrose/fish oil mixture.


Assuntos
Compostos de Alumínio/efeitos adversos , Doença de Alzheimer/prevenção & controle , Doença de Alzheimer/terapia , Óleos de Peixe/administração & dosagem , Lactatos/efeitos adversos , Óleos Vegetais/administração & dosagem , Primula , Ácido gama-Linolênico/análise , Doença de Alzheimer/induzido quimicamente , Doença de Alzheimer/metabolismo , Animais , Encéfalo/metabolismo , Butirilcolinesterase/metabolismo , Catalase/metabolismo , Colesterol/sangue , Modelos Animais de Doenças , Progressão da Doença , Ácidos Docosa-Hexaenoicos/análise , Ácido Eicosapentaenoico/análise , Óleos de Peixe/química , Masculino , Malondialdeído/metabolismo , Óleos Vegetais/química , Ratos , Ratos Endogâmicos
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