Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 63
Filtrar
1.
Endocrinol. diabetes nutr. (Ed. impr.) ; 67(1): 61-69, ene. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-186148

RESUMO

Aunque la nutrición de yodo en España ha mejorado en los últimos años, el problema no está resuelto del todo. Es preciso que las Instituciones sanitarias establezcan medidas para garantizar que la nutrición de yodo de toda la población sea la adecuada, especialmente entre los colectivos de mayor riesgo (niños y adolescentes, mujeres en edad fértil, mujeres embarazadas y madres lactantes). Debe aconsejarse un bajo consumo de sal, pero que esta sea yodada. También es imprescindible que las agencias de control alimentario establezcan un control efectivo sobre una adecuada yodación de la sal. En las futuras encuestas de salud debería incluirse indicadores sobre la nutrición de yodo. El estudio EUthyroid y la Declaración de Cracovia sobre la nutrición de yodo brindan una oportunidad para establecer un plan paneuropeo para la prevención de la deficiencia de yodo que debería ser considerada y aprovechada por las autoridades sanitarias


Although iodine nutrition in Spain has improved in recent years, the problem is not completely resolved. It is necessary that health institutions establish measures to ensure an adequate iodine nutrition of the population, especially among the highest risk groups (children and adolescents, women of childbearing age, pregnant women and nursing mothers). A low salt intake should be advised, but it should be iodized. It is also imperative that food control agencies establish effective control over adequate iodization of salt. Indicators on iodine nutrition should be included in future health surveys. The EUthyroid study and the Krakow Declaration on iodine nutrition provide an opportunity to set up a pan-European plan for the prevention of iodine deficiency that should be considered and used by health authorities


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Compostos de Iodo/uso terapêutico , Deficiência de Iodo/prevenção & controle , Valor Nutritivo , Iodo/administração & dosagem , Iodo/metabolismo , Aleitamento Materno , Dieta Hipossódica , Planejamento em Saúde/legislação & jurisprudência , Sociedades Médicas/legislação & jurisprudência , Sociedades Médicas/normas , Saúde Pública/legislação & jurisprudência , Saúde Pública/normas
2.
Curr Protoc Mouse Biol ; 9(2): e63, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31195428

RESUMO

Iodine-contrast micro-computed tomography (microCT) 3D imaging provides a non-destructive and high-throughput platform for studying mouse embryo and neonate development. Here we provide protocols on preparing mouse embryos and neonates between embryonic day 8.5 (E8.5) to postnatal day 4 (P4) for iodine-contrast microCT imaging. With the implementation of the STABILITY method to create a polymer-tissue hybrid structure, we have demonstrated that not only is soft tissue shrinkage minimized but also the minimum required time for soft tissue staining with iodine is decreased, especially for E18.5 to P4 samples. In addition, we also provide a protocol on using commercially available X-CLARITYTM hydrogel solution to create the similar polymer-tissue hybrid structure on delicate early post-implantation stage (E8.5 to E14.5) embryos. With its simple sample staining and mounting processes, this protocol is easy to adopt and implement for most of the commercially available, stand-alone microCT systems in order to study mouse development between early post-implantation to early postnatal stages. © 2019 by John Wiley & Sons, Inc.


Assuntos
Meios de Contraste/uso terapêutico , Compostos de Iodo/uso terapêutico , Camundongos , Microtomografia por Raio-X/métodos , Animais , Animais Recém-Nascidos , Embrião de Mamíferos , Microtomografia por Raio-X/instrumentação
3.
Rev. esp. nutr. comunitaria ; 23(2): 0-0, abr.-jun. 2017. graf
Artigo em Espanhol | IBECS | ID: ibc-165922

RESUMO

Fundamentos: El yodo es un mineral imprescindible para el normal funcionamiento del organismo humano. La ingesta de yodo, la mayoría de las veces, es totalmente dependiente de los alimentos elegidos en la dieta diaria cuando no se hace uso de la sal yodada. El objetivo de este trabajo fue estimar el uso de sal yodada en los hogares con niños en edad escolar de entre 6 y 12 años. Métodos: A través de una encuesta nutricional, dirigida a padres que respondían acerca de los hábitos alimentarios de sus hijos, se pudo obtener la información correspondiente. Sobre una población total de 312 niños que cursaban primaria en diferentes colegios de la ciudad de Valencia (España), se realizó un estudio observacional descriptivo transversal del cual se obtuvo una muestra de 245 cuestionarios, recogidos entre junio y diciembre de 2012. Resultados: El 47,6% de los hogares siempre utilizaban algún tipo de sal yodada sin combinar con sal común, mientras el 15,38% de los hogares consumían tanto sal común como algún tipo de sal yodada. Conclusiones: Cerca de la mitad de los hogares hacen uso de la sal yodada, de esta manera pueden beneficiarse de las propiedades que este mineral aporta a la dieta y evitar las importantes enfermedades que la carencia de este mineral provoca en las personas (AU)


Background: Iodine is an essential mineral for the normal function of the human organism. When iodized salt is not employed, the consumption- on most occasions - depends entirely on the foods chosen in the daily diet .The aim of this study was to evaluate the use of iodized salt in households of children between 6 and 12 years of age. Methods: By using a nutritional questionnaire completed by parents about their child’s eating habits, the corresponding information was obtained. In a total population of 312 children from various primary schools in the city of Valencia (Spain), an observational, descriptive cross-study was carried out. The result of which was an exhibit of 245 questionnaires gathered between June and December of 2012. Results: 47, 6% of households always and only use iodized salt whilst 15, 38% of households consume both iodized and non-iodized salt. Conclusions: Almost half of the households employ iodized salt, therefore benefiting from the properties of this mineral and avoiding the serious illnesses which the lack of the mineral can provoke.the Mediterranean diet and also a moderate physical activity, being greater among boys and younger (AU)


Assuntos
Humanos , Criança , Compostos de Iodo/administração & dosagem , Desenvolvimento Infantil/fisiologia , Alimentação Escolar , Iodo/administração & dosagem , Comportamento Alimentar/fisiologia , Cloreto de Sódio/administração & dosagem , Cloreto de Sódio/classificação , Serviços de Saúde Escolar , Compostos de Iodo/uso terapêutico , Inquéritos Nutricionais/estatística & dados numéricos , Estudos Transversais/métodos , Ingestão de Alimentos/fisiologia , Inquéritos e Questionários
4.
Ann Ist Super Sanita ; 52(4): 550-557, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27999227

RESUMO

Iodine deficiency disorders (IDD) still represent a major public health problem, with almost 30% of the world population being exposed to the consequences of nutritional iodine deficiency (ID). In Italy, despite a sustained policy of iodine prophylaxis, more than 10% of people is still affected with goiter, and a presumably higher rate of subjects may suffer from minor cognitive deficits due to inadequate iodine supply during antenatal life. This review of systematic observational studies carried out over thirty-five years (1980-2015) in a sentinel ID area in North-eastern Sicily highlights the changing phenotypes of IDD in this region. Over the years profound improvements in nutritional iodine status in North-eastern Sicily has occurred, due to both silent and active iodine prophylaxis. Endemic cretinism, resulting from severe iodine deficiency, has been progressively replaced by less serious deficits of intellectual and cognitive abilities, which nevertheless deserve proper attention.


Assuntos
Deficiências Nutricionais/epidemiologia , Iodo/deficiência , Hipotireoidismo Congênito/epidemiologia , Deficiências Nutricionais/dietoterapia , Humanos , Compostos de Iodo/uso terapêutico , Fenótipo , Sicília/epidemiologia
5.
Cochrane Database Syst Rev ; (4): CD003949, 2015 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-25897764

RESUMO

BACKGROUND: Surgical site infection rates in the month following clean surgery vary from 0.6% (knee prosthesis) to 5% (limb amputation). Due to the large number of clean surgical procedures conducted annually the costs of these surgical site infections (SSIs) can be considerable in financial and social terms. Preoperative skin antisepsis using antiseptics is performed to reduce the risk of SSIs by removing soil and transient organisms from the skin where a surgical incision will be made. Antiseptics are thought to be toxic to bacteria and therefore aid their mechanical removal. The effectiveness of preoperative skin preparation is thought to be dependent on both the antiseptic used and the method of application, however, it is unclear whether preoperative skin antisepsis actually reduces postoperative wound infection, and, if so, which antiseptic is most effective. OBJECTIVES: To determine whether preoperative skin antisepsis immediately prior to surgical incision for clean surgery prevents SSI and to determine the comparative effectiveness of alternative antiseptics. SEARCH METHODS: For this third update we searched just the Cochrane Wounds Group Specialised Register (searched 27 January 2015); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 12). SELECTION CRITERIA: Randomised controlled trials evaluating the use of preoperative skin antiseptics applied immediately prior to incision in clean surgery. There was no restriction on the inclusion of reports based on language of publication, date or publication status. DATA COLLECTION AND ANALYSIS: Data extraction and assessment of risk of bias were undertaken independently by two review authors. MAIN RESULTS: There were no new studies added to the review in the third updateThirteen studies were included in this review (2,623 participants). These evaluated several different types of skin antiseptics - leading to 11 different comparisons being made. Although the antiseptics evaluated differed between studies, all trials involved some form of iodine. Iodine in alcohol was compared to alcohol alone in one trial; one trial compared povidone iodine paint (solution type not reported) with soap and alcohol. Six studies compared different types of iodine-containing products with each other and five compared iodine-containing products with chlorhexidine-containing products.There was evidence from one study suggesting that preoperative skin preparation with 0.5% chlorhexidine in methylated spirits led to a reduced risk of SSI compared with an alcohol based povidone iodine solution: RR 0.47 (95% CI 0.27 to 0.82). However, it is important to note that the trial does not report important details regarding the interventions (such as the concentration of povidone iodine paint used) and trial conduct, such that risk of bias was unclear.There were no other statistically significant differences in SSI rates in the other comparisons of skin antisepsis. Overall the risk of bias in included studies was unclear.A mixed treatment comparison meta-analysis was conducted and this suggested that alcohol-containing products had the highest probability of being effective - however, again the quality of this evidence was low. AUTHORS' CONCLUSIONS: A comprehensive review of current evidence found some evidence that preoperative skin preparation with 0.5% chlorhexidine in methylated spirits was associated with lower rates of SSIs following clean surgery than alcohol-based povidone iodine paint. However this single study was poorly reported. Practitioners may therefore elect to consider other characteristics such as costs and potential side effects when choosing between alternatives.The design of future trials should be driven by the questions of high priority to decision makers. It may be that investment in at least one large trial (in terms of participants) is warranted in order to add definitive and hopefully conclusive data to the current evidence base. Ideally any future trial would evaluate the iodine-containing and chlorhexidine-containing solutions relevant to current practice as well as the type of solution used (alcohol vs. aqueous).


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Cuidados Pré-Operatórios , Infecção da Ferida Cirúrgica/prevenção & controle , Clorexidina/uso terapêutico , Etanol/uso terapêutico , Humanos , Compostos de Iodo/uso terapêutico , Povidona-Iodo/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto
6.
Eur J Oncol Nurs ; 19(2): 136-41, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25465773

RESUMO

PURPOSE OF THE RESEARCH: To compare the efficacy of dioctahedral smectite and iodine glycerin (DSIG) cream with topical mouth rinse (composed of saline, gentamicin and Vitamin B12) in treatment of chemotherapy induced oral mucositis (OM). METHODS AND SAMPLE: A total of 130 intensive chemotherapy or stem cells transplantation induced OM patients were recruited. Among these patients, 67 patients received topical mouth rinse and 63 patients received DSIG cream treatment. The OM would be treated on the OM appearance and sustained for 5 days. OM severity was measured daily using The American Oncology Nursing Society recommended Oral Assessment Guideline (OAG) score system. KEY RESULTS: Compared with topical mouth rinse treatment, a significant lower OAG score was observed in DSIG cream treated patients. Specifically, the OAG scores were respectively 12.1 ± 1.1, 12.0 ± 1.2, 11.3 ± 1.3 and 10.4 ± 1.3 from day 2 to day 5 in topical mouth rinse treatment subgroup. Correspondingly, the OAG scores were respectively 10.2 ± 1.0, 9.3 ± 0.9, 8.5 ± 0.6 and 8.0 ± 0.2 for DSIG cream treatment subset (all P < 0.05). Importantly, compared with topical mouth rinse treatment, the DSIG cream significantly shortened OM repair time (4.68 ± 0.98 vs. 8.76 ± 1.80 days, P < 0.001). After 5 days treatment, 54 patients (85.7%) obtained complete regression with an OAG score ≤8, and 7 patients (11.1%) had partial regression with an OAG score of 9-10 in DSIG cream treatment subgroup. However, only 2 patients (3.0%) obtained completed regression and 32 patients (47.8%) had partial regression in topical mouth rinse treatment cohort. Moreover, no serious side-effect was observed in both cohorts. CONCLUSIONS: Compared with topical mouth rinse, DSIG cream significantly lowered the OAG score and shortened OM duration.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Antineoplásicos/efeitos adversos , Compostos de Iodo/uso terapêutico , Silicatos/uso terapêutico , Estomatite/induzido quimicamente , Estomatite/tratamento farmacológico , Administração Tópica , Adulto , Idoso , Feminino , Glicerol/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Antissépticos Bucais/uso terapêutico , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Projetos Piloto , Creme para a Pele , Solventes/uso terapêutico , Estomatite/patologia , Adulto Jovem
8.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 33(1): 36-38, ene.-feb. 2014.
Artigo em Inglês | IBECS | ID: ibc-118730

RESUMO

The 131I-iodide (131I) whole-body scan, for thyroid carcinoma is at times difficult to interpret. In a diagnostic whole body 131I scan of a patient with follicular carcinoma, a posterior skull lesion was partially hidden by overlapping facial structures. On lateral head view, the abnormality was clearly evident. SPECT/CT and MRI showed the lesion originated in the occipital bone and had enlarged into the posterior fossa. The mass was surgically removed and the patient received 131I therapy for residual tissue. The study demonstrates a pitfall in the reading of two dimensional radioiodine images which can be overcome by SPECT or lateral imaging (AU)


La gammagrafía de cuerpo entero con yodo radiactivo (131I) para el cáncer de tiroides es, a veces, difícil de interpretar. En una gammagrafía diagnóstica de cuerpo entero con 131I en un paciente con carcinoma folicular, las estructuras faciales sobrepuestas ocultaban parcialmente una lesión craneal posterior. En una proyección lateral de la cabeza, la anomalía quedó claramente manifiesta. Las tomografías por emisión de fotón simple y axial computarizada (SPECT/TAC) y de resonancia magnética nuclear (RMN) mostraron que la lesión se originaba en el hueso occipital y se extendía hasta la fosa posterior. La masa fue extirpada quirúrgicamente y al paciente se le trató con 131I para tratar el tejido residual. Este estudio demuestra un fallo en la lectura de dos imágenes bidimensionales de yodo radioactivo que puede evitarse mediante el uso de SPECT o de la adquisición de imágenes laterales (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Glândula Tireoide/complicações , Neoplasias da Glândula Tireoide/diagnóstico , Carcinoma , Metástase Neoplásica , 3-Iodobenzilguanidina , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca/métodos , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca , Neoplasias da Glândula Tireoide , Cintilografia/métodos , Cintilografia , Compostos de Iodo/uso terapêutico , Medicina Nuclear/métodos
9.
An. pediatr. (2003, Ed. impr.) ; 80(1): 16-20, ene. 2014. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-118969

RESUMO

Introducción: El tratamiento con radioyodo en la enfermedad de Graves (EG) es una opción terapéutica curativa cada vez más utilizada en niños por encima de 5 años. En Estados Unidos su uso está muy extendido, pero en Europa sigue existiendo controversia respecto a su indicación en la edad pediátrica. Objetivo: Presentar nuestra experiencia con la administración de I131 en la EG en edad pediátrica y analizar su eficacia y seguridad. Pacientes y métodos: Estudio retrospectivo descriptivo de los pacientes pediátricos (< 18 años) diagnosticados de EG en nuestro hospital desde 1982 hasta 2012. Al alcanzar la pubertad, se ofreció una opción curativa a aquellos pacientes que no habían respondido al tratamiento con fármacos antitiroideos (AT). Analizamos las características de los pacientes, niveles de hormona tirotropa, T3 y T4, y autoanticuerpos, respuesta a AT, frecuencia de la remisión de la enfermedad post-I131, aparición de hipotiroidismo y efectos secundarios del I131.ResultadosDesde 1982 hasta 2012 fueron diagnosticados de EG 50 pacientes. Todos recibieron como tratamiento inicial AT, con una duración media 35,3 ± 25,9 meses. Se consiguió remisión permanente en el 46%. Se realizó tiroidectomía a 5 pacientes y se administró I131 a 14 pacientes. La dosis de yodo administrada osciló entre 8,5 y 13 mCi (10,9 ± 1,09). Se obtuvo remisión en el 100%. La tasa de hipotiroidismo permanente fue del 90%. No se observaron progresión de la oftalmopatía ni efectos secundarios en ningún paciente tratado con I131. Conclusiones: El tratamiento con 131I en la EG pediátrica es seguro, lleva a la remisión completa a costa de hipotiroidismo y no exacerba la oftalmopatía. Puede considerarse su utilización en mayores de 5 años cuando no existe respuesta a AT o ante efectos secundarios importantes con esta medicación (AU)


Introduction: Radioiodine is an important therapeutic option in young patients with Grave’s disease (GD). In the United States it is a widespread therapy, but in Europe its use in paediatrics is still controversial. Aim: To report our experience in radioiodine therapy of paediatric GD patients and analyse its effectiveness and safety. Patients and methods: We retrospectively studied our paediatric population (<18 years of age) with GD, diagnosed from 1982 to 2012. A curative option was offered to patients who did not respond to anti-thyroid drug (AT) at puberty. We analysed, the patient characteristics, TSH, T4, T3 and thyroid antibodies levels, AT response, remission post I131, side effects, and hypothyroidism rates. Results: A total of 50 patients were diagnosed with GD from 1982 to 2012. All patients received AT as initial treatment (mean duration: 35.3±25.9 months). Permanent remission was achieved in 46%. Thyroidectomy was performed in 5 patients, and 14 patients received I131 (mean dose: 10.9±1.09 mCi). Remission with I131 was obtained in 100%. The rate of permanent hypothyroidism was 90%. There was no progression of ophthalmopathy or side effects in any patientst reated with I131.Conclusion: Radioiodine treatment of paediatric GD patients is safe, leads to complete remission at the expense of hypothyroidism, and does not exacerbate ophthalmopathy. It can be considered in patients older than 5 years, who do no not respond to AT or with significant side effects with this medication (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Doença de Graves/tratamento farmacológico , Compostos de Iodo/uso terapêutico , Estudos Retrospectivos , Segurança do Paciente , Resultado do Tratamento
10.
Endocrinol Nutr ; 61(1): 27-34, 2014 Jan.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-24035326

RESUMO

Severe and mild iodine deficiency during pregnancy and lactation affects thyroid function of the mother and neonate as well as the infant's neuropsychological development. Studies performed in Spain confirm that most women are iodine deficient during pregnancy and lactation. Pregnant and breast feeding women and women planning to become pregnant should take iodine supplements.


Assuntos
Suplementos Nutricionais , Hipotireoidismo/prevenção & controle , Compostos de Iodo/uso terapêutico , Iodo/deficiência , Lactação , Complicações na Gravidez/prevenção & controle , Ensaios Clínicos Controlados como Assunto , Deficiências Nutricionais/sangue , Deficiências Nutricionais/dietoterapia , Deficiências Nutricionais/tratamento farmacológico , Deficiências Nutricionais/epidemiologia , Deficiências Nutricionais/prevenção & controle , Suplementos Nutricionais/efeitos adversos , Feminino , Sangue Fetal/química , Desenvolvimento Fetal/efeitos dos fármacos , Doenças Fetais/etiologia , Doenças Fetais/prevenção & controle , Aditivos Alimentares , Humanos , Hipotireoidismo/etiologia , Recém-Nascido , Iodo/metabolismo , Iodo/uso terapêutico , Compostos de Iodo/administração & dosagem , Compostos de Iodo/efeitos adversos , Compostos de Iodo/farmacologia , Necessidades Nutricionais , Gravidez , Complicações na Gravidez/tratamento farmacológico , Complicações na Gravidez/etiologia , Transtornos Puerperais/induzido quimicamente , Alimentos Marinhos , Cloreto de Sódio na Dieta/uso terapêutico , Espanha/epidemiologia , Tireoidite/induzido quimicamente , Tireotropina/sangue
11.
Cochrane Database Syst Rev ; (3): CD003949, 2013 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-23543526

RESUMO

BACKGROUND: Surgical site infection rates in the month following clean surgery vary from 0.6% (knee prosthesis) to 5% (limb amputation). Due to the large number of clean surgical procedures conducted annually the costs of these surgical site infections (SSIs) can be considerable in financial and social terms. Preoperative skin antisepsis using antiseptics is performed to reduce the risk of SSIs by removing soil and transient organisms from the skin where a surgical incision will be made. Antiseptics are thought to be toxic to bacteria and therefore aid their mechanical removal. The effectiveness of preoperative skin preparation is thought to be dependent on both the antiseptic used and the method of application, however, it is unclear whether preoperative skin antisepsis actually reduces postoperative wound infection, and, if so, which antiseptic is most effective. OBJECTIVES: To determine whether preoperative skin antisepsis immediately prior to surgical incision for clean surgery prevents SSI and to determine the comparative effectiveness of alternative antiseptics. SEARCH METHODS: For this second update we searched the The Cochrane Wounds Group Specialised Register (searched 7 August 2012), The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 7), Ovid MEDLINE  (1950 to July Week 4 2012), Ovid MEDLINE (In-Process & Other Non-Indexed Citations August 06, 2012), Ovid EMBASE (1980 to 2012 Week 31), EBSCO CINAHL (2007 to 3 August 2012). SELECTION CRITERIA: Randomised controlled trials evaluating the use of preoperative skin antiseptics applied immediately prior to incision in clean surgery. There was no restriction on the inclusion of reports based on language of publication, date or publication status. DATA COLLECTION AND ANALYSIS: Data extraction and assessment of risk of bias were undertaken independently by two review authors. MAIN RESULTS: Thirteen studies were included in this review (2,623 participants). These evaluated several different types of skin antiseptics - leading to 11 different comparisons being made. Although the antiseptics evaluated differed between studies, all trials involved some form of iodine. Iodine in alcohol was compared to alcohol alone in one trial; one trial compared povidone iodine paint (solution type not reported) with soap and alcohol. Six studies compared different types of iodine-containing products with each other and five compared iodine-containing products with chlorhexidine-containing products.There was evidence from one study suggesting that preoperative skin preparation with 0.5% chlorhexidine in methylated spirits led to a reduced risk of SSI compared with an alcohol based povidone iodine solution: RR 0.47 (95% CI 0.27 to 0.82). However, it is important to note that the trial does not report important details regarding the interventions (such as the concentration of povidone iodine paint used) and trial conduct, such that risk of bias was unclear.There were no other statistically significant differences in SSI rates in the other comparisons of skin antisepsis. Overall the risk of bias in included studies was unclear.A mixed treatment comparison meta-analysis was conducted and this suggested that alcohol-containing products had the highest probability of being effective - however, again the quality of this evidence was low. AUTHORS' CONCLUSIONS: A comprehensive review of current evidence found some evidence that preoperative skin preparation with 0.5% chlorhexidine in methylated spirits was associated with lower rates of SSIs following clean surgery than alcohol-based povidone iodine paint. However this single study was poorly reported. Practitioners may therefore elect to consider other characteristics such as costs and potential side effects when choosing between alternatives.The design of future trials should be driven by the questions of high priority to decision makers. It may be that investment in at least one large trial (in terms of participants) is warranted in order to add definitive and hopefully conclusive data to the current evidence base. Ideally any future trial would evaluate the iodine-containing and chlorhexidine-containing solutions relevant to current practice as well as the type of solution used (alcohol vs. aqueous).


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Cuidados Pré-Operatórios , Infecção da Ferida Cirúrgica/prevenção & controle , Clorexidina/uso terapêutico , Etanol/uso terapêutico , Humanos , Compostos de Iodo/uso terapêutico , Povidona-Iodo/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto
12.
Ann Pharm Fr ; 70(2): 75-81, 2012 Mar.
Artigo em Francês | MEDLINE | ID: mdl-22500958

RESUMO

More or less rapid radio-induction of thyroidian cancers is the main pathological consequence of an accidental exposure to ingested or inhaled radioactive iodines following a nuclear power plant accident. The prophylactic administration of potassium iodine in a single oral dose has to be practiced as soon as possible after the nuclear accident. The efficacy of this therapy depends on pharmacokinetics of radioidines. Iodines are rapidly and completely absorbed as iodides. The radioactive iodines, mainly iodine 131, concentrate in the thyroid gland because of a carrier-mediated transport by the Na-I symporter. Administration of stable iodine results in the symporter blockade, which limits the uptake of radioactive iodines by the thyroid and the duration of the internal irradiation. This irradiation will never exceed 3days if the therapy is started between 6h before the accidental exposure and 1h after. The pharmacist asked to dispense the tablets of stable iodine has a important place because, besides his advices on the optimal modalities of taking stable iodine and the risks of unwanted effects, he extend these advices to information on the radioactive risk and on measures of civil and sanitary protection.


Assuntos
Compostos de Iodo/uso terapêutico , Radioisótopos do Iodo/efeitos adversos , Neoplasias da Glândula Tireoide/etiologia , Neoplasias da Glândula Tireoide/prevenção & controle , Humanos , Exposição por Inalação , Compostos de Iodo/efeitos adversos , Compostos de Iodo/química , Compostos de Iodo/farmacocinética , Compostos de Iodo/farmacologia , Radioisótopos do Iodo/farmacocinética , Pulmão/metabolismo , Neoplasias Induzidas por Radiação/prevenção & controle , Liberação Nociva de Radioativos , Glândula Tireoide/metabolismo , Hormônios Tireóideos/biossíntese
13.
Otol Neurotol ; 32(2): 217-22, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21178805

RESUMO

HYPOTHESIS: 1) To assess the insertion characteristics of a disposable intracochlear catheter; and 2) to assess radiologically cochlear trauma induced by delivery catheter and electrode arrays. BACKGROUND: A catheter was designed to enter the scala tympani up to 15 mm and to acutely deliver pharmacological agents during cochlear implantation. METHODS: A cadaveric study was conducted in accordance to national regulation. Thirteen fresh temporal bones were evaluated radiologically. The intracochlear catheter used in this experiment has the same outer dimensions and profile as a standard MED-EL cochlear implant electrode array. We performed sequentially the introduction of the catheter, the injection of an iodine solution into the scala tympani via the catheter, the removal of the catheter, and finally an electrode array insertion. Ten to 15 µl of an iodine solution was injected into the scala tympani at depth of 15 mm. Four CT scans were sequentially performed after each step. RESULTS: The disposable intracochlear catheter could easily be inserted in all specimens. An insertion at depth of 15 mm was easily achieved every time. CT scans demonstrated that the iodine solution injected stayed in the scala tympani in all specimens. This was interpreted as indirect evidence of the integrity of the basilar membrane. CONCLUSION: Drug delivery during cochlear implantation using a flexible disposable intracochlear catheter has been demonstrated to be feasible and without radiological evidence of basilar membrane trauma to a distance of up to 15 mm, as demonstrated in 13 temporal bones.


Assuntos
Cóclea/diagnóstico por imagem , Implante Coclear/métodos , Sistemas de Liberação de Medicamentos , Cateterismo , Cateteres , Implantes Cocleares , Meios de Contraste , Difusão , Equipamentos Descartáveis , Eletrodos , Humanos , Compostos de Iodo/administração & dosagem , Compostos de Iodo/uso terapêutico , Iopamidol , Rampa do Tímpano/diagnóstico por imagem , Tomografia Computadorizada por Raios X
15.
Oncologist ; 15(7): 695-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20555019
16.
Rev. Círc. Argent. Odontol ; 67(208): 16-19, mayo 2010. ilus
Artigo em Espanhol | LILACS | ID: lil-597911

RESUMO

La miasis bucal es una enfermedad tropical, producida por ectoparásitos que se encuentra en resurgimiento, de acuerdo a diversos reportes. Se manifiesta como tumores ulcerados dolorosos, principalmente de localización palatina. Debido a esto, es importante que el odontólogo tenga conocimiento de sus aspectos epidemiológicos, clínicos, diagnósticos, terapéuticos y preventivos, ya que en la cavidad bucal se pueden presentar manifestaciones de dicha patología. En este artíciulo se expondrán las manifestaciones clínicas de dos pacientes que estudiamos y tratamos en la Cátedra de Clínica Estomatológica de la Facultad de Odontología de Buenos Aires.


Assuntos
Humanos , Feminino , Criança , Adolescente , Miíase/diagnóstico , Miíase/etiologia , Miíase/terapia , Manifestações Bucais , Aparelhos Ortodônticos Removíveis/efeitos adversos , Compostos de Iodo/uso terapêutico
17.
Rev. esp. med. nucl. (Ed. impr.) ; 29(2): 57-62, mar.-abr. 2010. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-78293

RESUMO

ObjetivoRealizar un análisis descriptivo de la implicación clínico-diagnóstica de la exploración con 123I-Iodobenzamida (IBZM) en los pacientes estudiados en nuestro centro por trastornos del movimiento sugerentes de Parkinson plus (PP).Material y métodoSe realizó SPECT con 123I-IBZM a 46 pacientes, procedentes de la consulta de trastornos del movimiento, por sospecha de PP. Según la clínica se distribuyeron en 3 grupos: 35 pacientes presentaban clínica atípica (CA) para enfermedad de Parkinson, 2 mostraban falta de respuesta al tratamiento habitual (FR) y en 9 se presentaban ambos factores (CA y FR). El resultado del SPECT se valoró únicamente de forma cualitativa.ResultadosDe los 35 pacientes con CA el 123I-IBZM apoyó el diagnóstico de PP en 15(42,9%), de los 2 con FR el estudio fue patológico en 1 y, de los 9 que presentaban ambos factores (CA y FR), el 123I-IBZM fue patológico en 6 casos (66,7%).ResultadosEn el 95,7% de la muestra (44 pacientes) la CA, con o sin FR, era el principal factor de sospecha de PP, y sólo en el 47,7% (22 pacientes) el 123I-IBZM resultó alterado. De estos 22 casos, en 20 el diagnóstico definitivo fue de PP (elevado valor predictivo positivo).ConclusiónEl estudio con 123I-IBZM es de gran utilidad en la práctica clínica, al proporcionar una información diagnóstica objetiva con implicaciones en el tratamiento y pronóstico de los pacientes con sospecha de PP(AU)


ObjectiveTo perform a descriptive analysis of the clinical and diagnostic implications of 123I-IBZM SPECT in the patients studied in our center for movement disorders suggestive of Parkinson-Plus Disease (PP).Subjects and methods123I-IBZM SPECT was performed in 46 patients referred from the movement disorders consultation due to suspicion of PP. According to their symptoms, they were distributed into 3 groups: 35 patients had atypical symptoms (AS) for Parkinson's Disease, 2 showed no response to standard therapy (NR) and 9 presented both factors (AS, NR). The results of SPECT were only assessed qualitatively.ResultsThe 123I-IBZM supported the diagnosis of PP in 15(42.9%) out of the 35 patients with AS. The 123I-IBZM was pathological in one of the two NR patients. Regarding the third group of patients (AS+NR), the 123I-IBZM was pathological in 6 cases (66.7%).ResultsIn 95.7% of our sample (44 patients), AS with or without NR was the main factor leading to suspicion of PP and the 123I-IBZM was altered in only 47.7% (22 patients). Of these 22 cases, the final diagnosis was PP (with high positive predictive value) in 20(91%).ConclusionThe study with 123I-IBZM is useful in the clinical practice because it provides objective diagnostic information with implications for the treatment and prognosis of patients with suspicion of PP(AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Diagnóstico Diferencial , Compostos de Iodo/administração & dosagem , Compostos de Iodo/uso terapêutico , Iofetamina/uso terapêutico , Doença de Parkinson/diagnóstico , Doença de Parkinson/tratamento farmacológico , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Valor Preditivo dos Testes , Doença de Parkinson/fisiopatologia , Doença de Parkinson , Medicina Nuclear/métodos , Receptores Dopaminérgicos/administração & dosagem , Antagonistas de Dopamina
18.
J Indian Soc Pedod Prev Dent ; 28(1): 18-24, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20215667

RESUMO

Antibacterial efficacy of formocresol, 2% gluteraldehyde and iodine-potassium iodide was assessed by obtaining cultures at consecutive appointments in multiple visit pulpectomies in primary molars. Formocresol and 2% gluteraldehyde were more effective as intracanal medicaments and caused significant reduction in the counts of aerobic and anaerobic microorganisms, thereby supporting the need for placing intracanal medicaments with antibacterial properties, in multiple visit pulpectomies in primary molars.


Assuntos
Antibacterianos/uso terapêutico , Dente Molar/patologia , Pulpectomia/métodos , Irrigantes do Canal Radicular/uso terapêutico , Dente Decíduo/patologia , Bactérias Aeróbias/efeitos dos fármacos , Bactérias Anaeróbias/efeitos dos fármacos , Criança , Pré-Escolar , Contagem de Colônia Microbiana , Cavidade Pulpar/microbiologia , Feminino , Formocresóis/uso terapêutico , Glutaral/uso terapêutico , Humanos , Compostos de Iodo/uso terapêutico , Masculino , Dente Molar/microbiologia , Abscesso Periapical/microbiologia , Abscesso Periapical/terapia , Iodeto de Potássio/uso terapêutico , Pulpite/microbiologia , Pulpite/terapia , Tratamento do Canal Radicular/métodos , Dente Decíduo/microbiologia , Cimento de Óxido de Zinco e Eugenol/uso terapêutico
19.
J Wound Care ; 18(8): 343-6, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19862874

RESUMO

OBJECTIVE: To compare the antimicrobial effectiveness of silver- and iodine-containing wound dressings against preformed mature biofilms of pathogenic wound bacteria grown in vitro. METHOD: Biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown within an in vitro flat bed perfusion biofilm model. Mature biofilms were removed and exposed to wound dressings containing either silver or iodine (Aquacel Ag and Iodozyme) within a static diffusion method, for up to 24 hours. This method was designed to reflect certain key features that determine antimicrobial activity within the wound. The numbers of viable bacteria surviving in the biofilms were determined at set time intervals over the test period. RESULTS: Both test dressings exerted an antimicrobial effect against the target species biofilms, although the iodine dressing was more efficacious under the experimental conditions employed. CONCLUSION: There are large and potentially significant differences (as measured in vitro) in the effectiveness of wound dressings containing broad-spectrum antimicrobial agents such as silver and iodine against specific types of bacterial biofilms.


Assuntos
Curativos Hidrocoloides , Biofilmes/efeitos dos fármacos , Carboximetilcelulose Sódica/uso terapêutico , Compostos de Iodo/uso terapêutico , Compostos de Prata/uso terapêutico , Infecção dos Ferimentos/tratamento farmacológico , Administração Tópica , Análise de Variância , Curativos Hidrocoloides/normas , Técnicas de Cultura de Células , Contagem de Colônia Microbiana , Avaliação Pré-Clínica de Medicamentos , Humanos , Modelos Lineares , Infecções por Pseudomonas/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Fatores de Tempo , Infecção dos Ferimentos/microbiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA