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1.
Expert Opin Drug Saf ; 19(1): 9-17, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31868031

RESUMO

Introduction: Reduced drinking has been debated as a treatment goal for heavy drinking alcohol-dependent patients, in whom treatment based on abstinence is not always an option. Nalmefene was the first drug approved by the European Medicines Agency (2013) with the indication of reduced drinking in high drinking risk level alcohol-dependent patients. Six years after its introduction in Europe, data from clinical experience can be compared with those from preclinical studies and pivotal registration studies to evaluate what nalmefene has added to the treatment of AUD.Areas covered: Systematic review of efficacy and safety data of nalmefene use in humans from preclinical, phase III and phase IV studies, including systematic reviews, meta-analyses, cost-effectiveness analyses, and other secondary analyses.Expert opinion: Nalmefene introduces a paradigm change in the treatment of AUD that makes it appealing to patients that are reluctant to embrace abstinence, and facilitate patient-centered care in heavy users. However, information regarding safety data in special populations (e.g., patients with alcohol-related diseases, pregnancy, psychiatric disease), and direct comparisons with other potential drugs for alcohol reduction are further needed. Despite the promising role of nalmefene, there are still some factors that limit its wide prescription further than in specialized settings.


Assuntos
Alcoolismo/tratamento farmacológico , Naltrexona/análogos & derivados , Antagonistas de Entorpecentes/administração & dosagem , Consumo de Bebidas Alcoólicas/prevenção & controle , Transtornos Relacionados ao Uso de Álcool/tratamento farmacológico , Aprovação de Drogas , Humanos , Naltrexona/administração & dosagem , Naltrexona/efeitos adversos , Antagonistas de Entorpecentes/efeitos adversos
2.
Int. arch. otorhinolaryngol. (Impr.) ; 23(4): 445-450, Out.-Dez. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1024455

RESUMO

Introduction: For the singer, the voice is a medium used to express feelings that capture the listener. Every singing style has specific demands, and a vocal alteration may prevent the singer from meeting them. Objective: To compare the singing style, the vocal habits, and the general health data of professional singers. Methods: Cross-sectional, quantitative and retrospective study of a survey database. Data on the singing style, the vocal habits, and the health conditions and history of 57 professional singers, 31 female singers and 26 male singers, aged from 19 to 57 years old (average of 32 years old), from a mid-sized town were analyzed. Results: There was a prevalence of female (54 ± 2%) popular singers (91 ± 2%), in the adult age (51 ± 2%), nonsmokers (89 ± 2%), nonusers of alcohol (77 ± 2%), with respiratory problems (53 ± 2%), mainly rhinitis (23 ± 2%), and without other health problems. There was a significant use of alcohol in males ( p = 0.010); among the alcohol users, there was a significant presence of respiratory problems ( p = 0.046), of pharyngitis/tonsillitis ( p = 0.003), and of gastroesophageal reflux (GER) ( p = 0.043); there was a significant presence of GER in subjects reporting endocrine problems ( p = 0.023), of gastritis ( p = 0.023), and of pharyngitis/tonsillitis ( p = 0.030). Conclusion: There was a predominance of adult professional popular female singers, with complaints of respiratory issues (with a higher prevalence of rhinitis), without other general health issues, of nonsmokers, and of nonusers of alcohol (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Qualidade da Voz , Saúde do Trabalhador , Canto , Doenças Respiratórias , Gastropatias , Consumo de Bebidas Alcoólicas , Estudos Transversais , Uso de Tabaco
3.
Eur. j. psychol. appl. legal context (Internet) ; 11(2): 81-92, jul.-dic. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-183602

RESUMO

Traffic safety is an important social problem. Many accidents are due to non-compliance with traffic regulations. Serious or repeated offenses are sanctioned with penalty points or court conviction, and sanctions can lead to disqualification from driving. This paper explores the relevance of alcohol consumption and personality factors as predictors of driving disqualification. The aim of the study is to determine whether the behaviors of persistent offenders and their propensity for law-breaking are related to their characteristics and patterns of drinking. A sample of 358 drivers participated in the study: 126 non-offender habitual drivers and 232 persistent traffic offenders disqualified from driving for serious or repeated traffic offenses, 127 of them after conviction, 105 without conviction (by accumulation of penalties). Participants were given a battery of tests measuring a set of explanatory personality and alcohol consumption factors. We used a cross-sectional study design and performed statistical analysis of variance and regression searching for differences among the groups. The results reveal group effects, with significant differences in a number of factors between traffic offenders and non-offenders, and between both categories of offenders in a number of variables, including traffic violations that lead to demerit points and/or loss of a driver's license and crash involvement. Certain variables, including problem drinking, high levels of activity or excitement, penchant for thrill or sensation seeking, and propensity to hostility while driving, can accurately predict group membership. Alcohol disorders are the best predictors of disqualification from driving for serious or repeat traffic offenses, both penalized and convicted


La seguridad vial es un importante problema social. Muchos accidentes se deben al incumplimiento de las normas de tráfico. Las infracciones graves o reiteradas se sancionan por la vía administrativa o judicial y en ambos casos las sanciones pueden suponer la pérdida del permiso de conducir. Este artículo explora la relevancia del alcohol y la personalidad como factores predictivos. El objetivo del estudio es determinar si el comportamiento delictivo de los infractores persistentes está relacionado con sus características de personalidad y patrones de consumo de alcohol. Se utilizó una muestra de 358 conductores: 232 infractores persistentes, a los que les había sido retirado el carnet de conducir (127 por sentencia judicial y 105 por pérdida total de puntos), y 126 conductores habituales no infractores. Se administró una batería de pruebas que miden un conjunto de factores explicativos de personalidad y consumo de alcohol. Se utilizó un diseño transversal y se realizaron análisis estadísticos de varianza y regresión buscando diferencias entre los grupos. Los resultados revelan diferencias significativas en el tipo de infracciones y accidentes entre infractores de tráfico y no infractores y entre ambas categorías de infractores. Además, ciertas variables, como el abuso de alcohol, altos niveles de actividad, activación emocional, búsqueda de sensaciones y la tendencia a la hostilidad durante la conducción, pueden predecir con precisión la pertenencia a uno u otro grupo. Los problemas con la bebida son el mejor predictor de la pérdida del permiso de conducir, tanto por condena como por acumulación de sanciones


Assuntos
Humanos , Masculino , Feminino , Adulto , Condução de Veículo/psicologia , Consumo de Bebidas Alcoólicas/efeitos adversos , Comportamento Perigoso , Transtornos da Personalidade/psicologia , Direção Distraída/psicologia , Direção Agressiva/psicologia , Acidentes de Trânsito/estatística & dados numéricos , Assunção de Riscos , Avaliação de Resultado de Intervenções Terapêuticas
4.
Georgian Med News ; (294): 182-187, 2019 Sep.
Artigo em Russo | MEDLINE | ID: mdl-31687973

RESUMO

The aim of this study was to establish the prevalence, relative risks, and predictive factors of the development of arterial hypertension (AH) in workers of a uranium processing enterprise (UPE). An open cross-sectional comparative study of 809 UPE workers was conducted. The compared them to the 696 workers of the bearing plant, located at a distance of 10 km from UPE. Stratification was performed and odds ratios (OR), gross (RR) and standardized relative (SRR) risks of hypertension were calculated. Our results revealed a high prevalence of hypertension among UPE workers (24.8%), as well as greater risk of development of hypertension among workers of UPE in comparison to the personnel of the non-uranium enterprise: RR=2.4 and SRR=2.9. The most significant predictors of hypertension were burdened heredity (OR = 13.6), total radiation dose (OR=1.5), overweight (OR=1.1), high anxiety (OR=0.5) and systematic use of alcohol (OR=0.5). Thus, among workers chronically exposed to radiation toxicity, high prevalence of hypertension, excessive RR and SRR of developing hypertension and the presence of risk factors for hypertension were established.


Assuntos
Indústrias Extrativas e de Processamento/estatística & dados numéricos , Hipertensão/epidemiologia , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Urânio/toxicidade , Consumo de Bebidas Alcoólicas/epidemiologia , Ansiedade/complicações , Ansiedade/epidemiologia , Estudos Transversais , Humanos , Hipertensão/etiologia , Cazaquistão/epidemiologia , Obesidade/complicações , Exposição Ocupacional/estatística & dados numéricos , Prevalência , Doses de Radiação , Fatores de Risco
5.
Medicine (Baltimore) ; 98(44): e17867, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689880

RESUMO

Glycogen storage disease (GSD) type IX, characterized by liver enlargement and elevated aminotransferase levels, is the most frequent type of GSD. The global incidence of GSD type IXa is only about 1/100,000 individuals. Case reports of GSD type IX are rare in China. We present the first case report of GSD type IXa in Northeast China caused by mutation of PHKA2.An 11-year-old boy was referred to our hospital because of liver enlargement with consistently elevated transaminase levels over 6 months.Histopathological results following an ultrasound-guided liver biopsy confirmed a diagnosis of GSD. Further genetic testing showed that the patient had GSD type IXa caused by the c.133C>T mutation in PHAK2.We placed the patient on a high-protein and high-starch diet and provided hepatoprotective and supportive therapy.The patient's transaminase levels decreased significantly and were nearly normal at 10-month follow-up.This is the first reported case of GSD type IXa in Northeast China. We hope that the detailed and complete report of this case will provide a reference for the diagnosis of liver enlargement of unknown etiology in future clinical practice.


Assuntos
Carcinoma Hepatocelular/virologia , Hepatite B Crônica/genética , Interleucinas/genética , Cirrose Hepática/virologia , Neoplasias Hepáticas/virologia , Polimorfismo de Nucleotídeo Único , Adulto , Consumo de Bebidas Alcoólicas/efeitos adversos , Grupo com Ancestrais do Continente Asiático/genética , Carcinoma Hepatocelular/genética , Estudos de Casos e Controles , Progressão da Doença , Feminino , Hepatite B Crônica/complicações , Humanos , Cirrose Hepática/genética , Neoplasias Hepáticas/genética , Masculino , Pessoa de Meia-Idade , Mutação Puntual , Estudos Retrospectivos , Fumar/efeitos adversos
9.
Pan Afr Med J ; 33: 210, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692887

RESUMO

Introduction: Hypertension ranks third in the world, after underweight and unsafe sex, in the list of six major risk factors contributing to the global disease. In Kenya, the prevalence stands at 24% in the general population, while among the young adults, the incidence of hypertension has been reported to be in the rise; a fact attributed to increased number of risks. We therefore sought to determine awareness and risk factors of hypertension among young adults attending Tenwek hospital. Methods: A case-control study of young adults ages 18-35, involving 80 cases and 80 controls at Tenwek Mission Hospital, Bomet County. Cases included males and females newly diagnosed with hypertension (diagnosed at the time of data collection) and if they reported taking antihypertensive medication and reported as hypertensives in the hospital records at any clinic visit or at interview, while controls included persons with no history of hypertension. Results: Those having a BMI≥25 were 3.05 times more likely to be hypertensive (OR: 3.05, 95% CI 1.26, 7.40; p=0.014). Having a relative suffering from hypertension increased almost thrice the odds of being hypertensive (OR: 2.78, 95% CI 1.20, 6. 46; p=0.018). Not drinking alcohol reduced the chance of suffering from hypertension by 70%, (OR=0.30, 95% CI 0.11, 0.81; p=0.017). Conclusion: The prevalence of hypertension in younger adults is not as low as generally perceived. Preventive measures should be formulated in a manner to address variety of major risk factors in young adults.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Anti-Hipertensivos/uso terapêutico , Saúde da Família/estatística & dados numéricos , Hipertensão/epidemiologia , Adolescente , Adulto , Consumo de Bebidas Alcoólicas/efeitos adversos , Estudos de Casos e Controles , Feminino , Humanos , Hipertensão/tratamento farmacológico , Hipertensão/etiologia , Quênia/epidemiologia , Masculino , Prevalência , Fatores de Risco , Adulto Jovem
11.
J Law Med ; 26(4): 786-799, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31682357

RESUMO

In 2004 legislators in New South Wales relied on Australia's National Competition Policy to change the reason for determining alcohol outlet approvals from a "needs" to a "harm minimisation" basis. This was predicated on the application of a rational social impact assessment (SIA) process. Within a short time, however, the volume of liquor licence applications began to erode that intention and the delays that applicants encountered placed politicians under pressure to fast-track the process. Subsequent liquor legislation retained the statutory obligation on decision-makers to ensure no overall detrimental social impact associated with the approval of an alcohol outlet licence. However, legislative amendments to the approval process reduced the number and kinds of licences and authorisations to which the social impact test applied and encouraged other shortcuts which undermine the validity of these assessments. The resulting statutory approval system in practice relegates SIA to an exception rather than the rule and has revealed the relative weakness of SIA as a public health safeguard.


Assuntos
Consumo de Bebidas Alcoólicas , Mudança Social , Bebidas Alcoólicas , Austrália , Comércio , New South Wales
12.
Psychiatr Prax ; 46(8): 445-450, 2019 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-31683335

RESUMO

OBJECTIVE: Substance use patterns and sociodemographic variables of Berlin's party scene were investigated to derive preventive measures and harm reduction services, which meet the needs of the consumers. METHODS: A questionnaire was used online and in the field among Berlin partygoers (N = 877) and structured interviews (N = 20) were conducted with professionals working in this area, including social workers, emergency medical service, police and club owners and users. RESULTS: A risky consumption pattern was found in 67 % of participants, who also stated need for counseling and a wish for reduction of their substance use. Of all preventive measures, drug checking was requested most often. Substances with the highest prevalence were alcohol, cannabis, amphetamine, MDMA, cocaine and ketamine, whereas methamphetamine and new psychoactive substances were barely stated. CONCLUSION: There is an urgent need to expand current preventive measures. There is a willingness of the scene to use according services, especially by those who need it the most.


Assuntos
Consumo de Bebidas Alcoólicas , Redução do Dano , Transtornos Relacionados ao Uso de Substâncias , Consumo de Bebidas Alcoólicas/epidemiologia , Consumo de Bebidas Alcoólicas/psicologia , Berlim , Alemanha , Humanos , Prevalência , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Transtornos Relacionados ao Uso de Substâncias/psicologia
14.
Epidemiol Health ; 41: e2019036, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31606979

RESUMO

OBJECTIVES: The study was to conduct a comparative assessment of drinking behaviors and overall health among pregnant and breastfeeding women. METHODS: This study used data collected from the Korean Community Health Survey in 2015. Data obtained from 2,156 pregnant or breastfeeding women were analyzed using descriptive statistics, the t-test, the chi-square test, and the Pearson correlation coefficient. RESULTS: Current drinking and alcohol consumption were higher among pregnant women than among breastfeeding women. Depression was twice as common among breastfeeding women than among pregnant women, and stress was much higher among breastfeeding women as well. Breastfeeding women also had lower subjective dental health and more unmet medical needs than pregnant women. CONCLUSIONS: Although pregnant women were in better overall health than breastfeeding women, many of them were unable to stop drinking, which is a risky and adverse health behavior that negatively affects maternal and fetal health. In order to reduce drinking among pregnant and breastfeeding women, it is necessary to develop a tailored, standardized educational program and national guidelines.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Aleitamento Materno/estatística & dados numéricos , Nível de Saúde , Gestantes/psicologia , Adulto , Feminino , Inquéritos Epidemiológicos , Humanos , Gravidez , República da Coreia
16.
Rev Saude Publica ; 53: 79, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31576940

RESUMO

OBJECTIVE: To determine the prevalence of work ability (WA) and describe characteristics of the subgroup with poor WA among military police officers. METHODS: A descriptive and cross-sectional study with 329 male military police officers engaged in street patrolling in Salvador, Bahia, Brazil, selected by proportionate stratified sampling. The Work Ability Index and a structured form were used to collect information about age, education, marital status, housing, salary, car ownership, work hours, rank (official or enlisted), drinking, smoking, frequency of vigorous physical activity, and obesity. Data were analyzed by uni and bivariate statistical techniques. RESULTS: The work ability of the 329 military police officers was classified as poor (10.3%), moderate (28.9%), good (34.7%), and excellent (26.1%), with mean score of 37.8 and standard deviation of 7.3 points. Policemen with poor work ability, compared with those with moderate, good or excellent WA, presented higher proportions of individuals who did not own their residences (p < 0.001), with work hours above eight hours/day (p < 0.026), and obesity (p < 0.001). In the subgroup of the 26 policemen who concomitantly did not own their residences, worked more than eight 8 hours/day and were obese, the prevalence of poor work ability was 31.0%. The prevalence of poor WA was 31.0% among the 29 policemen who were simultaneously obese and did not own their residences and of 27.9% among the 43 policemen who were obese and work hours above eight hours/day. CONCLUSIONS: A high percentage of military police officers from Salvador presented poor or moderate work ability, which may hamper or compromise their policing activities. The prevalence of poor work ability was higher among the policemen who did not own their residences, worked more than 8 hours/day and were obese.


Assuntos
Polícia/estatística & dados numéricos , Avaliação da Capacidade de Trabalho , Adulto , Consumo de Bebidas Alcoólicas/epidemiologia , Brasil/epidemiologia , Estudos Transversais , Exercício , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Prevalência , Valores de Referência , Fumar/epidemiologia , Fatores Socioeconômicos , Carga de Trabalho/estatística & dados numéricos , Adulto Jovem
17.
Rev Bras Epidemiol ; 22Suppl 1(Suppl 1): e190009, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31576985

RESUMO

INTRODUCTION: Knowledge about risky sexual behavior among young people has been widely acknowledged as a key tool to controlling the spread of HIV. This article aimed at presenting the risk behavior of Brazilian Army conscripts toward HIV infection according to the country's geographic regions. . METHOD: We collected data from 37,282 conscripts, aged 17 to 22, during enlistment in the Brazilian Army in 2016. The prevalence of HIV infection, both self-reported and measured through laboratory results, and risk behavior factors were estimated by region. RESULTS: 75% of the sample of conscripts reported to have already started sexual activity, and the average age of their sexual initiation was 15. Condom use varied according to the type of sexual relationship, being lower among steady partners and greater among less stable relationships. HIV prevalence assessed by laboratory tests was 0.12% across the country and the highest prevalence was observed in the North region (0.24%). Alcohol and illicit drug usage was higher in the South region. DISCUSSION: The study allowed the observation of risk behavior monitoring for HIV infection among young Brazilians. Lower condom usage among steady partners may be contributing to an increase in the number of HIV-infected individuals. CONCLUSION: Results suggest the need to intensify prevention campaigns to disseminate safe sex practices among young people, in addition to the expansion of testing offer to this population.


Assuntos
Infecções por HIV/etiologia , Comportamentos de Risco à Saúde , Militares/estatística & dados numéricos , Adolescente , Adulto , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/epidemiologia , Brasil/epidemiologia , Preservativos/estatística & dados numéricos , Estudos Transversais , Geografia , Infecções por HIV/epidemiologia , Humanos , Masculino , Prevalência , Medição de Risco , Fatores de Risco , Comportamento Sexual/estatística & dados numéricos , Transtornos Relacionados ao Uso de Substâncias/complicações , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Adulto Jovem
18.
Anaesthesia ; 74(12): 1580-1588, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31637700

RESUMO

Pre-operative intervention to improve general health and readiness for surgery is known as prehabilitation. Modification of risk factors such as physical inactivity, smoking, hazardous alcohol consumption and an unhealthy weight can reduce the risk of peri-operative morbidity and improve patient outcomes. Interventions may need to target multiple risk behaviours. The acceptability to patients is unclear. We explored motivation, confidence and priority for changing health behaviours before surgery for short-term peri-operative health benefits in comparison with long-term general health benefits. A total of 299 participants at three UK hospital Trusts completed a structured questionnaire. We analysed participant baseline characteristics and risk behaviour profiles using independent sample t-tests and odds ratios. Ratings of motivation, confidence and priority were analysed using paired sample t-tests. We identified a substantial prevalence of risk behaviours in this surgical population, and clustering of multiple behaviours in 42.1% of participants. Levels of motivation, confidence and priority for increasing physical activity, weight management and reducing alcohol consumption were higher for peri-operative vs. longer term benefits. There was no difference for smoking cessation, and participants reported lower confidence for achieving this compared with other behaviours. Participants were also more confident than motivated in reducing their alcohol consumption pre-operatively. Overall, confidence ratings were lower than motivation levels in both the short- and long-term. This study identifies both substantial patient desire to modify behaviours for peri-operative benefit and the need for structured pre-operative support. These results provide objective evidence in support of a 'pre-operative teachable moment', and of patients' desire to change behaviours for health benefits in the short term.


Assuntos
Atitude , Comportamentos Relacionados com a Saúde , Período Pré-Operatório , Adulto , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas , Terapia Comportamental , Exercício , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Motivação , Comportamento de Redução do Risco , Abandono do Hábito de Fumar , Inquéritos e Questionários , Reino Unido , Perda de Peso , Adulto Jovem
19.
Rev Saude Publica ; 53: 86, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31644769

RESUMO

OBJECTIVE: To estimate the co-occurrence of the major risk factors for chronic diseases in adults (18-59 years old) and older people (≥ 60 years old) living in Brazilian state capitals and the Federal District. METHODS: Cross-sectional study with population-based data from 35,448 adults and 18,726 older people collected in the Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (System of Surveillance of Risk and Protective Factors for Chronic Diseases by Telephone Survey - Vigitel) in 2015. The prevalence of each of the five risk factors (smoking, overweight, physical inactivity, alcohol and unhealthy diet) was estimated, as well as their co-occurrence for the different possible combinations, according to socioeconomic and health self-assessment variables. The independent associations were verified via multinomial logistic regression to obtain the estimates of the odds ratio (OR) and corresponding 95% confidence intervals. RESULTS: At least two risk factors were present in 38.5% of the adults and 37.0% of the older participants. The male adults and older participants who did not have private health insurance and classified their health as average or poor/very poor were more likely to have two or more concurrent risk behaviors. The greater chance of co-occurrence of smoking and alcohol abuse in adults (adjusted OR = 3.52) and older people (adjusted OR = 2.94) stands out. CONCLUSIONS: The subgroups with increased risk of developing multiple unhealthy behaviors and the most prevalent behaviors were identified. These findings are expected to contribute to the better targeting of health promotion and preventive care. It is worth noting that, for the adoption of healthy lifestyle habits, macro-social and inter-sectoral policies are more effective.


Assuntos
Doença Crônica/epidemiologia , Medição de Risco/métodos , Adolescente , Adulto , Distribuição por Idade , Fatores Etários , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/epidemiologia , Brasil/epidemiologia , Comorbidade , Estudos Transversais , Feminino , Comportamentos de Risco à Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Sobrepeso/complicações , Sobrepeso/epidemiologia , Prevalência , Fatores de Risco , Comportamento Sedentário , Distribuição por Sexo , Fumar/efeitos adversos , Fumar/epidemiologia , Fatores Socioeconômicos , Organização Mundial da Saúde , Adulto Jovem
20.
Medicine (Baltimore) ; 98(40): e17218, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577712

RESUMO

Health examination is an important method for early detection of people with different risk of stroke. This study estimates the risk of stroke and identify risk factors for people who underwent health examinations at the Health Examination Center at West China Hospital, Sichuan University from July 2014 to February 2018.A total of 31,464 people were recruited in this study and divided into 3 groups (low risk, moderate risk, and high risk) according to risk of stroke. We explored possible factors associated with the risk of stroke by using multivariable stepwise logistic regression analysis.Among the participants, 17,959 were at low risk, 11,825 were at moderate risk, and 1680 were at high risk. Age, smoking, alcohol consumption, body mass index, uric acid, diastolic pressure, systolic pressure, triglycerides, low-density lipoprotein cholesterol, glucose, and brachial-ankle pulse wave velocity (baPWV) were independent significant risk factors for stroke, whereas high-density lipoprotein cholesterol was an independent protective factor for stroke. Interestingly, with increasing age, the percentage of people at moderate or high risk of stroke was increased. The percentages of people at moderate and high risk of stroke were also increased with respect to the stages of baPWV.This study showed that >40% of the participants were at moderate or high risk of stroke, especially the older participants. Several factors were related to the risk of stroke, especially baPWV. Some preventive action may be adopted early, and more attention can be paid to the health examination population.


Assuntos
Exame Físico/estatística & dados numéricos , Acidente Vascular Cerebral/epidemiologia , Adulto , Fatores Etários , Consumo de Bebidas Alcoólicas/epidemiologia , Índice Tornozelo-Braço , Pressão Sanguínea , Índice de Massa Corporal , China/epidemiologia , Fumar Cigarros/epidemiologia , Estudos Transversais , Feminino , Humanos , Estilo de Vida , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco , Fatores Sexuais , Fatores Socioeconômicos
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