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1.
Sensors (Basel) ; 21(6)2021 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-33802750

RESUMO

Milk is an important dietary requirement for many populations due to its high nutritional value. However, increased demand has also made it prone to fraudulent activity. In this sense, scientists have sought to develop simple, low-cost, and portable techniques to achieve quality control of milk in industry and farms as well. This work proposes a new instrumentation system based on acoustic propagation and advanced signal processing techniques to identify milk adulteration by industrial contaminants. A pair of transmitter-receiver low-cost piezoelectric transducers, configured in a pitch-catch mode, propagated acoustic waves in the bovine milk samples contaminated with 0.5% of sodium bicarbonate, urea, and hydrogen peroxide. Signal processing approaches such as chromatic technique and statistical indexes like the correlation coefficient, Euclidian norm and cross-correlation square difference were applied to identify the contaminants. According to the presented results, CCSD and RMSD metrics presented more effectiveness to perform the identification of milk contaminants. However, CCSD was 2.28 × 105 more sensitivity to distinguish adulteration in relation to RMSD. For chromatic clustering technique, the major selectivity was observed between the contamination performed by sodium bicarbonate and urea. Therefore, results indicate that the proposed approach can be an effective and quick alternative to assess the milk condition and classify its contaminants.


Assuntos
Contaminação de Alimentos , Leite , Acústica , Animais , Bovinos , Contaminação de Medicamentos , Contaminação de Alimentos/análise , Ureia
2.
Molecules ; 26(6)2021 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-33809747

RESUMO

The authors developed a 1H qNMR test procedure for identification and quantification of impurity A present in gabapentin active pharmaceutical ingredient (API) and gabapentin products. The validation studies helped to determine the limit of quantitation and assess linearity, accuracy, repeatability, intermediate precision, specificity, and robustness of the procedure. Spike-and-recovery assays were used to calculate standard deviations, coefficients of variation, confidence intervals, bias, Fisher's F test, and Student's t-test for assay results. The obtained statistical values satisfy the acceptance criteria for the validation parameters. The authors compared the results of impurity A quantification in gabapentin APIs and capsules by using the 1H qNMR and HPLC test methods.


Assuntos
Contaminação de Medicamentos/prevenção & controle , Gabapentina/química , Cápsulas/química , Cromatografia Líquida de Alta Pressão/métodos , Limite de Detecção , Espectroscopia de Ressonância Magnética/métodos , Padrões de Referência , Reprodutibilidade dos Testes
3.
J Med Toxicol ; 17(2): 218-221, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33528767

RESUMO

The COVID-19 pandemic has triggered outbreaks of unanticipated toxicities, including methanol toxicity. Multiple methanol outbreaks have been described, including contaminated hand sanitizer in the southwest USA. In this case, we describe a fatal case of methanol toxicity from hand sanitizer ingestion, geographically separated from the outbreak in the southwest USA and prior to the announcement of nationwide warnings by the Food and Drug Administration (FDA). The product was identified as one later recalled by the FDA for methanol contamination. Additionally, the consumption in this case was related to a desire to conceal alcohol consumption from family members. This case of methanol toxicity should increase awareness of the ease of which contaminated products can be widely distributed and of the use of alternative ethanol-containing products to obscure relapse in alcohol use disorder.


Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Alcoólicos , Alcoolismo/complicações , Contaminação de Medicamentos , Desinfecção das Mãos , Higienizadores de Mão/envenenamento , Metanol/envenenamento , Adulto , Consumo de Bebidas Alcoólicas/psicologia , Alcoólicos/psicologia , Alcoolismo/psicologia , Evolução Fatal , Humanos , Masculino
4.
AAPS PharmSciTech ; 22(3): 78, 2021 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-33604777

RESUMO

Six Australian and five overseas complementary medicines (CM) and meal replacement shake products were analysed for potential adulteration with two common active pharmaceutical ingredients, caffeine and sibutramine, using thin-layer chromatography and mass spectrometry. The declared amount of caffeine in each product was also reviewed. Finally, the products were examined for heavy metal contamination using inductively coupled plasma-mass spectrometry. The results showed that there was no detected adulteration of either caffeine (for those products that did not list caffeine as an ingredient) or sibutramine in the 11 products; however, based on the product labels, one Australian and one overseas (two in total) CM product contained more than the maximum daily safety limit (400 mg) of caffeine. Potentially excessive lead and/or chromium was detected in six products, including four Australian products and two products purchased online. One Australian CM product appeared to contain these heavy metals at concentrations at, or exceeding, the safety limits specified in the United States Pharmacopeia or set by the World Health Organization. The overconsumption of caffeine and heavy metals has the potential of causing significant health effects in consumers.


Assuntos
Terapias Complementares/normas , Contaminação de Medicamentos , Medicamentos sem Prescrição/análise , Cafeína/análise , Ciclobutanos/análise , Humanos , Espectrometria de Massas/métodos , Metais Pesados/análise
5.
Int J Pharm Compd ; 25(1): 6-12, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33503004

RESUMO

Over the last century, the concept and use of the cleanroom have continually evolved to provide an increasingly restricted environment with a low burden of contaminants (especially those that are airborne). Although no cleanroom in active use can be kept sterile, the particulate burden circulated via airflow and deposited on surfaces in such areas must be reduced to levels considered acceptable, especially when sterile compounding is performed. In this article on cleanroom cleanliness, pivotal events in cleanroom development are briefly reviewed, contamination control in the sterile-compounding environment is discussed, factors that affect levels of contamination in cleanroom suites are examined, and suggestions for contamination prevention are presented.


Assuntos
Contaminação de Medicamentos , Ambiente Controlado , Composição de Medicamentos
6.
ACS Appl Mater Interfaces ; 13(3): 3521-3527, 2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33440931

RESUMO

Small-molecule impurities, such as N-nitrosodimethylamine (NDMA), have infiltrated the generic drug industry, leading to recalls in commonly prescribed blood pressure and stomach drugs in over 43 countries since 2018 and directly affecting tens of millions of patients. One promising strategy to remove small-molecule impurities like NDMA from drug molecules is by size exclusion, in which the contaminant is removed by selective adsorption onto a (micro)porous material due to its smaller size. However, current solution-phase size-exclusion separations are primarily limited by the throughput-selectivity trade-off. Here, we report a bioinspired solution to conquer these critical challenges by leveraging the assembly of atomically precise building blocks into hierarchically porous structures. We introduce a bottom-up approach to form micropores, mesopores, and macroscopic superstructures simultaneously using functionalized oxozirconium clusters as building blocks. Further, we leverage recent advances in photopolymerization to design macroscopic flow structures to mitigate backpressure. Based on these multiscale design principles, we engineer simple, inexpensive devices that are able to separate NDMA from contaminated drugs. Beyond this urgent model system, we expect this design strategy to open up hitherto unexplored avenues of nanomaterial superstructure fabrication for a range of size-exclusion purification strategies.


Assuntos
Dimetilnitrosamina/isolamento & purificação , Compostos Organometálicos/química , Zircônio/química , Adsorção , Contaminação de Medicamentos , Extração Líquido-Líquido , Modelos Moleculares , Porosidade
7.
Pharm Dev Technol ; 26(3): 328-334, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33428504

RESUMO

Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more recently proposed in COVID-19 therapy. Hydroxychloroquine is only available in tablets which are not easy to administer for pediatric and geriatric patients, and patients unable to swallow such as patients found in intensive care units. The aim of this work was to develop and optimize a ready to use liquid hydroxychloroquine formulation and to carry out the corresponding chemical and microbiological stability studies. The formulation was evaluated for ease of preparation, physical properties, and palatability. Its stability was performed at ambient temperature and under refrigeration. After 6 months of stability testing, the results showed no pH change, no drug loss, no microbial development, and no visual change. The formulation, employing excipients in a range that EMA has recommended, showed chemical and microbiological stability for at least 6 months even in the worst storage conditions.


Assuntos
Antimaláricos/química , Hidroxicloroquina/química , Cromatografia Líquida de Alta Pressão , Composição de Medicamentos , Contaminação de Medicamentos/prevenção & controle , Estabilidade de Medicamentos , Humanos , Controle de Qualidade , Suspensões , Paladar
8.
Artigo em Inglês | MEDLINE | ID: mdl-33477433

RESUMO

The coupled effect of seawater intrusion and inland freshwater recharge plays an important role in contamination transport in coastal heterogeneous aquifer. In this study, the effects of seawater intrusion and inland recharge on contamination transport were investigated by conducting laboratory experiments and numerical simulations. The laboratory tests were conducted in a sand tank considering two scenarios, namely the conditions of landward and seaward hydraulic gradients. The SEAWAT software was applied for validating the contaminant transport in coastal heterogeneous aquifer. The results indicated that the simulated seawater wedge and contours of the saltwater contaminant matched the observed ones well. The length of the seawater wedge in the scenario of seaward hydraulic gradient was smaller than that in the scenario of landward hydraulic gradient, which reflected that the large quantity of inland recharge have a negative effect on the invasion process of seawater. The plume moved mainly downward in the heterogeneous unconfined aquifer for both scenarios. The pollution plume became concave at the interface between each two layers, which was because the velocity of contaminant plume migration increased gradually from the upper layer to lower layer. The migration direction of the front of the plume was consistent with the direction of hydraulic gradient, which indicated that it was influenced by the water flowing. The maximum area of plume in the scenario of seaward hydraulic gradient was slightly smaller than that in the scenario of landward hydraulic gradient. The maximum area and vertical depth of the pollutant plume were sensitive to the hydraulic conductivity, dispersivity and contamination concentration. This study was of great significance to the controlling of pollution and utilization of freshwater resources in coastal areas.


Assuntos
Água Subterrânea , Laboratórios , Contaminação de Medicamentos , Água Doce , Água do Mar
9.
Yakugaku Zasshi ; 141(1): 125-133, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-33390439

RESUMO

The immunosuppressant azathioprine (AZA) is classified as a hazardous drug. AZA contamination during tablet-splitting increases exposure risk. However, there is no study on contamination and exposure during AZA tablet splitting and dispensing. AZA tablet splitting and dispensing methods were classified based on whether tweezers are used during splitting and packaging. In Dispensing Method (1), no tweezers were used in either step. In Dispensing Method (2), no tweezers were used during tablet splitting, but were used during packaging. In Dispensing Method (3), tweezers were used in both steps. After AZA half-tablet split-dispensing, we quantified the adherent AZA removed from the tools, packaging machines, and dispensing counters by three consecutive wipings with water-dampened polypropylene cloths. A large amount of AZA adhered to the gloves used in Dispensing Methods (1) and (2), wherein tablets were placed with gloved hands, compared with Dispensing Method (3), wherein tablets were held with tweezers. Thus, the gloves must be replaced before touching the packaging paper during the final step. After three consecutive wipings, AZA was not detected at most of the sites in the third round. Thus, we recommend that (1) AZA tablet splitting should be performed while wearing gloves, (2) the gloves should be changed before packaging the half tablets, and (3) the tools, packaging machines, and dispensing counters should be wiped twice or thrice with a water-dampened cloth after dispensing.


Assuntos
Azatioprina , Composição de Medicamentos/métodos , Contaminação de Medicamentos/prevenção & controle , Embalagem de Medicamentos/métodos , Imunossupressores , Exposição Ocupacional/prevenção & controle , Azatioprina/efeitos adversos , Imunossupressores/efeitos adversos , Comprimidos
11.
Sci Total Environ ; 754: 142005, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33254893

RESUMO

The first national survey of Emerging Organic Contaminants (EOCs) involved sampling 121 wells located throughout New Zealand and analysis for a suite of 29 EOCs. This survey was carried out in conjunction with the 2018 national survey of pesticides in groundwater, a survey that is conducted on a four-yearly basis which included the analysis of glyphosate for first time. A total of 227 EOCs were detected in the 85 wells (70%). There were 29 different EOCs in the analytical suite and 25 different EOCs were detected in at least one well. The highest concentration measured was 655 ng/L for sucralose, an artificial sweetener. These results indicate that EOCs, sourced from either animal or human effluents/activities, are making their way into shallow groundwater systems and can be detected at low concentrations. A total of 135 wells were analysed for glyphosate, glufosinate and their principal metabolites. There was only one detection of glyphosate at a concentration of 2.1 µg/L. This well showed evidence of poor wellhead protection and the contamination likely came from containers that were stored near the well. A total of 279 wells were sampled and analysed for pesticides and 68 wells (24.4%) contained detectable residues of pesticides, with 28 of these wells having two or more pesticides detected. The maximum number of pesticides detected in one well was six. None of the sampled wells exceeded the Maximum Acceptable Value (MAV) for drinking water in New Zealand and the concentrations of most of the detected pesticides were equivalent to less than 0.5% of the MAV. Comparisons with earlier National Surveys of pesticides in groundwater in New Zealand indicate the frequencies of pesticide detections have remained similar over the last 16 years, with higher detection frequencies occurring before that time.


Assuntos
Água Subterrânea , Praguicidas , Poluentes Químicos da Água , Animais , Contaminação de Medicamentos , Monitoramento Ambiental , Humanos , Nova Zelândia , Poços de Água
12.
Biomed Pharmacother ; 133: 111047, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33378954

RESUMO

Traditional Chinese medicines (TCMs) are medicines that are widely used in oriental countries under the guidance of ancient Chinese medicinal philosophies. With thousands of years of experiences in fighting against diseases, TCMs are gaining increasing importance in the world. Although the efficacy of TCMs is well recognized in clinic, the toxicity of TCMs has become a serious issue around the world in recent years. In general, the toxicity of TCMs is caused by the toxic medicinal compounds and contaminants in TCMs such as pesticides, herbicides, and heavy metals. Recent studies have demonstrated that gut microbiota can interact with TCMs and thus influence the toxicity of TCMs. However, there is no focused review on gut microbiota and the toxicity of TCMs. Here, we summarized the influences of the gut microbiota on the toxicity of medicinal compounds in TCMs and the corresponding mechanisms were offered. Then, we discussed the relationships between gut microbiota and the TCM contaminants. In addition, we discussed the methods of manipulating gut microbiota to reduce the toxicity of TCMs. At the end of this review, the perspectives on gut microbiota and the toxicity of TCMs were also discussed.


Assuntos
Bactérias/metabolismo , Contaminação de Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Medicamentos de Ervas Chinesas/efeitos adversos , Microbioma Gastrointestinal , Intestinos/microbiologia , Medicina Tradicional Chinesa/efeitos adversos , Bactérias/imunologia , Biotransformação , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/microbiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Medicamentos de Ervas Chinesas/metabolismo , Microbioma Gastrointestinal/efeitos dos fármacos , Interações Hospedeiro-Patógeno , Humanos , Intestinos/efeitos dos fármacos , Intestinos/imunologia , Fatores de Risco
13.
Chemosphere ; 262: 127477, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32799136

RESUMO

Focus on the safety of herbal medicines has mainly been directed towards the presence of intrinsic toxicity, as found in the cases of renal and hepatic dysfunction caused by aristolochic acids. However, contamination from extrinsic hazards may impart an even greater reduction in their safety and efficacy. This study reveals that pesticides were present in the majority (88%) of a comprehensive cross-section (n = 1771) of herbal medicine samples. Alarmingly, more than half (59%) contained pesticides over the European Pharmacopoeia (EP) limit, and 43% of them contained 35 varieties of banned, extremely toxic pesticides, eight of which were detected at levels over 500 times higher than the default Maximum Residue Limit (MRL). DDTs, carbofuran, and mevinphos were confirmed as being among the most risk-inducing pesticides by three different risk assessment methods, reported to produce carcinogenic, genotoxic, reproductive, and developmental effects, in addition to carrying nephrotoxicity and hepatotoxicity. In light of these findings, and withstanding that extrinsic hazards can be controlled unlike intrinsic toxicity, the authors here strongly recommend the application of herbal medicine quality-control measures and solutions to safeguard against a neglected but certainly potentially serious health risk posed to the majority of the global population that consumes herbal medicines.


Assuntos
Contaminação de Medicamentos , Medicamentos de Ervas Chinesas/análise , Praguicidas/análise , Carbofurano , Cromatografia Gasosa , Cromatografia Líquida/métodos , Cromatografia Gasosa-Espectrometria de Massas/métodos , Humanos , Resíduos de Praguicidas/análise , Medição de Risco , Espectrometria de Massas em Tandem/métodos
14.
Zhongguo Zhong Yao Za Zhi ; 45(17): 4158-4162, 2020 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-33164401

RESUMO

The enzyme linked immunosorbent assay of aflatoxin has been adopted in Chinese Pharmacopoeia(2020 edition). Based on high-throughput screening of monoclonal antibodies technology, monoclonal antibodies that can specifically recognize the aflatoxin B_1 and the total amount of aflatoxin B_1, B_2, G_1, and G_2 in Chinese herbal medicines were prepared. By optimizing the concentration of coating antibody, enzyme-labeled antigen, and the reaction system of enzyme-linked immunosorbent assay, the enzyme linked immunosorbent assay(ELISA) were developed for detection of aflatoxins in Chinese herbal medicines, decoction pieces, and preparation of Chinese medicine. In this method, the recovery test of actual samples is 60%-120%, and the relative standard deviation is less than 15%. In addition, in view of the complicated and expensive pretreatment methods for the determination of aflatoxin in Chinese herbal medicine, we developed a highly efficient pretreatment method of liquid-liquid extraction of aflatoxin in Chinese herbal medicine without immunoaffinity column. As an effective method for the detection of aflatoxin, the ELISA can effectively reduce the aflatoxins testing cost of traditional Chinese medicine, and promote the detection ability at earlier stages of production, and strengthen the quality supervision of traditional Chinese medicine.


Assuntos
Aflatoxinas , Medicamentos de Ervas Chinesas , Aflatoxina B1 , Anticorpos Monoclonais , Contaminação de Medicamentos , Ensaio de Imunoadsorção Enzimática
15.
Gan To Kagaku Ryoho ; 47(9): 1337-1340, 2020 Sep.
Artigo em Japonês | MEDLINE | ID: mdl-33130695

RESUMO

The filter extraction method is a new, simple method for evaluating anticancer drug contamination in air. The method involves installing a filter in the exhaust port of an exhaust duct on a facility's air conditioner, then collecting and measuring fine particles of the antineoplastic agents adsorbed onto the filter. In this study, we analyzed the utility of maintaining continuous filter extraction for measuring cyclophosphamide and 5-fluorouracil contamination. The filters were installed in 3 areas of an outpatient chemotherapy room and then left in place for approximately 5 months. Results revealed the presence of cyclophosphamide and 5-fluorouracil in all 3 areas. However, the amounts and ratios of detected drugs differed among survey sites; this may have been caused by factors such as drug preparation, administration, and excretion. We conclude that the filter extraction method can be used continuously for monitoring anticancer drug contamination in air; thus, it can be utilized to monitor healthcare workers' occupational exposure to inhaled anticancer drugs. Indeed, the filter extraction method may be useful as a novel environmental monitoring technique.


Assuntos
Poluentes Ocupacionais do Ar , Antineoplásicos , Exposição Ocupacional , Poluentes Ocupacionais do Ar/análise , Antineoplásicos/análise , Ciclofosfamida , Contaminação de Medicamentos , Humanos
18.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 6155-6158, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33019376

RESUMO

Worldwide revenue of pharmaceutical market is more than 1200 billion USD [1] and that of counterfeit medicines is around 200 billion USD [2][3]. Counterfeit medicines can be detected by technical experts using visual inspection or through sophisticated lab and relevant methods. However, such methods require time, sample preparation and technical expertise with lab setup. These methods are not feasible and scalable to be used in the field by the general public. The objective of our research work was to detect counterfeit medicines using simpler and faster method using hyperspectral sensing. In this experiment, a visible - near infrared (350nm - 1050nm) hyperspectral device was used to capture spectral signature of the medicines. We used 24 medicine tablets of different companies. To imitate counterfeit medicines, tablet powders were adulterated by adding different levels of calcium carbonate. Spectral signatures were captured from original stage to all stages of adulterations and analyzed using machine learning (multilayer perceptron classifier). Result shows that we are able to achieve more than 90% classification accuracy. Portable hyperspectral sensing combined with medicines spectral database can be a good field level test method for detection of counterfeit medicines, as it is very fast, easy to use and does not require technical expertise.


Assuntos
Medicamentos Falsificados , Contaminação de Medicamentos , Pós , Comprimidos
20.
Farm. hosp ; 44(5): 192-197, sept.-oct. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-195146

RESUMO

OBJETIVO: Estudiar los excipientes e impurezas de los diferentes medicamentos comercializados de docetaxel y conocer la incidencia de los diversos eventos adversos derivados del uso de docetaxel y su repercusión clínica en pacientes con cáncer de mama en el contexto de adyuvancia o neoadyuvancia. MÉTODO: Estudio observacional, longitudinal, prospectivo y multicéntrico en 26 hospitales de Madrid, Cataluña, Andalucía y Comunidad Valenciana. Se caracterizaron las distintas formulaciones de docetaxel en cuanto a pH, cantidad de docetaxel e impurezas. Se evaluó la incidencia acumulada de eventos adversos de cualquier grado estratificados por tipo de medicamento, analizando las diferencias mediante el test de χ2.RESULTADOS: Se detectaron diferencias estadísticamente significativas entre las distintas formulaciones de docetaxel en cuanto a la incidencia acumulada por ciclo de: modificación de dosis, anemia, reacciones de hipersensibilidad y anafilaxia, neuropatía, toxicidad palmo-plantar y dermatológica, toxicidad ungueal y edema facial. La formulación con un menor contenido en impurezas presentó mejores resultados en modificación de dosis, visitas a urgencias, e incidencia de anemia y edema facial, pero peores en hospitalización, neutropenia febril, neuropatía motora y toxicidad palmo-plantar. CONCLUSIONES: Los resultados muestran diferencias en la incidencia de los eventos adversos de los distintos medicamentos con docetaxel comercializados en nuestro país, con diferencias significativas entre ellos en algunas de las variables estudiadas. No se ha podido identificar un medicamento con un mejor perfil de toxicidad. Tampoco se ha podido establecer su relación con respecto a la composición de excipientes e impurezas


OBJECTIVE: To analyze the excipients and impurities contained in the various docetaxel products available on the market and find out whether they may be responsible for any of the different adverse events associated with the use of docetaxel in patients with breast cancer receiving adjuvant or neoadjuvant treatment. METHOD: This is a prospective, multicenter, longitudinal observational, study carried in 26 hospitals in Madrid, Catalonia, Andalusia, and the Valencia Region. The different docetaxel formulations were characterized in terms of their pH, amount of the active ingredient and impurities. The cumulative incidence of adverse events of any grade was evaluated. Adverse events were stratified by drug type and differences were analyzed by means of a chi-square test. RESULTS: Statistically significant differences were found between the different docetaxel formulations in the cumulative per-cycle incidence of: dosage change, anemia, hypersensitivity reactions and anaphylaxis, neuropathy, palmoplantar and dermal toxicity, ungual toxicity and facia edema. The formulation with the lowest content of impurities showed better results in terms of change of dosage, visits to the emergency room and incidence of anemia and facial edema. However, it was associated with poorer results regarding hospitalization, febrile neutropenia, motor neuropathy and palmoplantar toxicity. CONCLUSIONS: The results of the study showed differences in the incidence of adverse events of the different docetaxel products available in Spain. Such differences were statistically significant for some of the variables analyzed. The study was not able to determine which of the products offered the best toxicity profile. Nor was it possible to establish a correlation with respect to the composition of excipients or the content of impurities


Assuntos
Humanos , Feminino , Docetaxel/toxicidade , Neoplasias da Mama/tratamento farmacológico , Docetaxel/efeitos adversos , Quimioterapia Adjuvante/efeitos adversos , Medicamentos Genéricos/efeitos adversos , Estudos Longitudinais , Estudos Prospectivos , Contaminação de Medicamentos
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