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2.
Artigo em Inglês | MEDLINE | ID: mdl-34769821

RESUMO

Promoting the intention of farmers to participate in straw recycling is an effective way to alleviate the contradiction between environmental pollution, scarcity of environmental resources, and sustainable development. In this study, social trust and value perception were integrated into the theory of planned behavior to build a theoretical framework of farmers' intention to participate in straw recycling, considering the influences of three different pro-environmental publicity modes. A field investigation was used to collect research data in six sample villages. Finally, 761 valid questionnaires were collected, and partial least squares structural equation modeling was applied to test the research hypotheses. The results showed that the influence of attitudes, subjective norms, perceived behavior control, value perception, and social trust on farmers' straw recycling intentions was different among different pro-environmental publicity modes. Among the three pro-environmental publicity modes, the concentrated pro-environmental publicity mode has the best effect of promoting straw recycling intentions among farmers. This study introduces some targeted suggestions on the aspects of pro-environmental publicity theory and management practice based on the above research results.


Assuntos
Fazendeiros , Intenção , Agricultura , Atitude , Controle Comportamental , Humanos , Inquéritos e Questionários
3.
Neural Netw ; 144: 507-521, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34601363

RESUMO

Our brain can be recognized as a network of largely hierarchically organized neural circuits that operate to control specific functions, but when acting in parallel, enable the performance of complex and simultaneous behaviors. Indeed, many of our daily actions require concurrent information processing in sensorimotor, associative, and limbic circuits that are dynamically and hierarchically modulated by sensory information and previous learning. This organization of information processing in biological organisms has served as a major inspiration for artificial intelligence and has helped to create in silico systems capable of matching or even outperforming humans in several specific tasks, including visual recognition and strategy-based games. However, the development of human-like robots that are able to move as quickly as humans and respond flexibly in various situations remains a major challenge and indicates an area where further use of parallel and hierarchical architectures may hold promise. In this article we review several important neural and behavioral mechanisms organizing hierarchical and predictive processing for the acquisition and realization of flexible behavioral control. Then, inspired by the organizational features of brain circuits, we introduce a multi-timescale parallel and hierarchical learning framework for the realization of versatile and agile movement in humanoid robots.


Assuntos
Inteligência Artificial , Robótica , Controle Comportamental , Simulação por Computador , Humanos , Aprendizagem
4.
Cyberpsychol Behav Soc Netw ; 24(9): 593-598, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34491845

RESUMO

The behavioral aspect of cybersecurity has gained more attention in recent years. By their actions, people can improve the security of their devices and organizations, but also hinder the successful implementation of security in these areas. As awareness campaigns where information is merely distributed are not effective, we designed a cybersecurity serious game applicable for cybersecurity training. The effectiveness of this game was experimentally tested against a noncybersecurity game that did or did not contain cybersecurity information, through measures of the theory of planned behavior. Results showed that the cybersecurity game resulted in higher self-reported scores on attitudes, perceived behavioral control, intentions, and behavior compared with both noncybersecurity games. For subjective norms, we only found an effect in the comparison between the cybersecurity game and the noncybersecurity game without additional information.


Assuntos
Segurança Computacional , Intenção , Controle Comportamental , Humanos
5.
Dement. neuropsychol ; 15(3): 331-338, Sept. 2021. tab
Artigo em Inglês | LILACS | ID: biblio-1339796

RESUMO

ABSTRACT Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder accompanied by behavioral and personality changes and/or language deterioration. Its behavioral variant (bvFTD) is the main clinical presentation. Objective: This study aims to investigate the treatment alternatives for bvFTD available so far. Methods: We conducted a narrative review of bvFTD treatment options. We used PubMed and Lilacs databases with the terms "frontotemporal dementia" or "behavioral variant frontotemporal dementia" combined with "treatment," "pharmacological treatment," or "disease-modifying drugs." Results: The articles retrieved and selected in the research pointed out that there is no specific treatment approved for bvFTD so far. The current proposals are limited to handle the cardinal behavioral symptoms of the disorder. Disease-modifying drugs are under development and may be promising, especially in the monogenic presentations of FTD. Conclusions: There are numerous approaches to treat the core symptoms of bvFTD, most of them based on low-quality research. To date, there are no drugs with a disease-specific therapeutic recommendation for bvFTD. Treatments are often investigated guided by primary psychiatric disorders with similar symptoms and should be chosen by the predominant symptom profile.


RESUMO A demência frontotemporal (DFT) é um transtorno neurodegenerativo progressivo acompanhado de deterioração do comportamento e da personalidade e/ou da linguagem. A variante comportamental (DFTvc) é a principal apresentação clínica. Objetivos: Investigar as alternativas de tratamento disponíveis para a DFTvc até o momento. Métodos: Realizou-se uma revisão narrativa das opções de tratamento da DFTvc. Os bancos de dados PubMed e Lilacs foram utilizados com os termos "demência frontotemporal" ou "variante comportamental da demência frontotemporal" combinados com "tratamento", "tratamento farmacológico" ou "drogas modificadoras de doença". Resultados: Os artigos recuperados e selecionados na pesquisa indicaram que não há nenhum tratamento específico aprovado até o momento para DFTvc. As propostas atuais são limitadas ao tratamento dos sintomas comportamentais cardinais do transtorno. As drogas modificadoras de doença estão em desenvolvimento e podem ser promissoras, especialmente nas apresentações monogênicas da DFT. Conclusões: Há inúmeras abordagens para tratar os principais sintomas DFTvc, a maioria delas baseada em pesquisas de baixa qualidade. Até o momento, não existem medicamentos com uma recomendação terapêutica específica para a DFTvc. Os tratamentos são frequentemente investigados guiados por distúrbios psiquiátricos primários com sintomas semelhantes e devem ser escolhidos pelo perfil de sintomas predominante.


Assuntos
Humanos , Controle Comportamental , Tratamento Farmacológico , Demência Frontotemporal , Revisão
6.
BMC Womens Health ; 21(1): 290, 2021 08 06.
Artigo em Inglês | MEDLINE | ID: mdl-34362375

RESUMO

OBJECTIVE: Cervical cancer is considered treatable as long as it is detected early and managed effectively. Pap smear test is a screening tool that plays an important role in the early detection, prevention and can prevent any early cervical cell changes from becoming cancer. This study aims to survey the effect of educational programs based on beliefs, subjective norms, and perceived behavior control on doing the pap-smear test in a sample of Iranian women. MATERIALS AND METHODS: This experimental interventional study was performed on 300 women admitted to Fasa City, Fars Province, Iran health centers in 2018-2019. A questionnaire consisting of demographic information, knowledge, Health Belief Model, and Theory of Planned Behavior constructs were used to measure on doing of Pap smear test in women before and after 6 months' educational intervention. RESULTS: The results revealed that 6 months after the intervention, 108 women (72%) in the experimental group and only 9 women (6%) in the control group received the Pap smear test. CONCLUSIONS: The current research results revealed that education based on the combination of the health Belief model and theory of planned behavior might be promoting participation and an increasing rate of receiving Pap smear tests in women.


Assuntos
Controle Comportamental , Teste de Papanicolaou , Detecção Precoce de Câncer , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Irã (Geográfico)
7.
Am J Med ; 134(11): 1424-1426, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34339676

RESUMO

BACKGROUND: A decrease in coronavirus disease 2019 (COVID-19) vaccination rates has led some states to consider various incentives to boost demand for vaccines. On May 13, 2021, Ohio announced a free weekly lottery for individuals who received at least 1 COVID-19 vaccination. This study seeks to rigorously quantify the impact of Ohio's vaccination lottery. METHODS: A synthetic control consisting of a weighted combination of other states was used to approximate the demographic characteristics, new cases, and vaccination rates in Ohio prior to the lottery announcement. The difference in vaccination rates in Ohio and the synthetic control following the lottery announcement was then used to estimate the lottery's impact. RESULTS: Prior to the lottery announcement, Ohio and synthetic Ohio had similar demographic characteristics and new case rates. Ohio and synthetic Ohio also had identical first vaccination rates. By the final lottery enrollment date of June 20, the percentage of the population with first vaccinations increased to 47.41% in Ohio and 46.43% in synthetic Ohio for a difference of 0.98% (95% confidence interval [CI] 0.42-1.54). CONCLUSION: An additional 114,553 Ohioans received vaccinations as a result of the Vax-a-Million program (95% CI 49,094-180,012) at a cost of approximately $49 per Ohioan vaccinated (95% CI $31-$114). However, a majority of Ohioans remained unvaccinated by the end of the lottery, indicating that additional efforts are needed to address barriers to vaccination. This synthetic control approach may also be useful to evaluate other COVID-19 incentive programs.


Assuntos
Controle Comportamental/métodos , COVID-19 , Programas de Imunização , Vacinação em Massa , Motivação , Cobertura Vacinal , COVID-19/epidemiologia , COVID-19/prevenção & controle , Feminino , Humanos , Programas de Imunização/métodos , Programas de Imunização/organização & administração , Programas de Imunização/estatística & dados numéricos , Masculino , Vacinação em Massa/psicologia , Vacinação em Massa/estatística & dados numéricos , Pessoa de Meia-Idade , Ohio/epidemiologia , SARS-CoV-2 , Cobertura Vacinal/métodos , Cobertura Vacinal/estatística & dados numéricos , Recusa de Vacinação/psicologia
8.
Nat Hum Behav ; 5(8): 980-989, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34294901

RESUMO

In the past decade, behavioural science has gained influence in policymaking but suffered a crisis of confidence in the replicability of its findings. Here, we describe a nascent heterogeneity revolution that we believe these twin historical trends have triggered. This revolution will be defined by the recognition that most treatment effects are heterogeneous, so the variation in effect estimates across studies that defines the replication crisis is to be expected as long as heterogeneous effects are studied without a systematic approach to sampling and moderation. When studied systematically, heterogeneity can be leveraged to build more complete theories of causal mechanism that could inform nuanced and dependable guidance to policymakers. We recommend investment in shared research infrastructure to make it feasible to study behavioural interventions in heterogeneous and generalizable samples, and suggest low-cost steps researchers can take immediately to avoid being misled by heterogeneity and begin to learn from it instead.


Assuntos
Ciências do Comportamento , Formulação de Políticas , Reprodutibilidade dos Testes , Projetos de Pesquisa , Inteligência Artificial , Controle Comportamental , Causalidade , Humanos , Erro Experimental
9.
PLoS One ; 16(6): e0252648, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34170919

RESUMO

Patient safety is an important healthcare issue worldwide, and patient accidents in the operating room can lead to serious problems. Accordingly, we investigated the explanatory ability of a modified theory of planned behavior to improve patient safety activities in the operating room. Questionnaires were distributed to perioperative nurses working in 12 large hospitals in Korea. The modified theory of planned behavior data from a total of 330 nurses were analyzed. The conceptual model was based on the theory of planned behavior data, with two additional organizational factors-job factors and safety management system. Individual factors included attitude, subjective norms, perceived behavioral control, behavioral intention, and patient safety management activities. Results indicated that job factors were negatively associated with perceived behavioral control. The patient safety management system was positively associated with attitude, subjective norm, and perceived behavioral control. Attitude, subjective norm, and perceived behavioral control were positively associated with behavioral intention. Behavioral intention was positively associated with patient safety management activities. The modified theory of planned behavior effectively explained patient safety management activities in the operating room. Both organizations and individuals are required to improve patient safety management activities.


Assuntos
Recursos Humanos de Enfermagem no Hospital/estatística & dados numéricos , Salas Cirúrgicas/estatística & dados numéricos , Segurança do Paciente/estatística & dados numéricos , Gestão da Segurança/estatística & dados numéricos , Inquéritos e Questionários , Adulto , Atitude , Controle Comportamental/métodos , Controle Comportamental/psicologia , Estudos Transversais , Feminino , Humanos , Intenção , Masculino , Modelos Teóricos , Salas Cirúrgicas/normas , Segurança do Paciente/normas , Período Perioperatório , Gestão da Segurança/métodos , Gestão da Segurança/organização & administração
11.
BMJ ; 373: n1022, 2021 05 18.
Artigo em Inglês | MEDLINE | ID: mdl-34006604

RESUMO

OBJECTIVE: To evaluate whether opt out framing, messaging incorporating behavioral science concepts, or electronic communication increases the uptake of hepatitis C virus (HCV) screening in patients born between 1945 and 1965. DESIGN: Pragmatic randomized controlled trial. SETTING: 43 primary care practices from one academic health system (Philadelphia, PA, USA) between April 2019 and May 2020. PARTICIPANTS: Patients born between 1945 and 1965 with no history of screening and at least two primary care visits in the two years before the enrollment period. INTERVENTIONS: This multilevel trial was divided into two studies. Substudy A included 1656 eligible patients of 17 primary care clinicians who were randomized in a 1:1 ratio to a mailed letter about HCV screening (letter only), or a similar letter with a laboratory order for HCV screening (letter+order). Substudy B included the remaining 19 837 eligible patients followed by 417 clinicians. Active electronic patient portal users were randomized 1:5 to receive a mailed letter about HCV screening (letter), or an electronic patient portal message with similar content (patient portal); inactive patient portal users were mailed a letter. In a factorial design, patients in substudy B were also randomized 1:1 to receive standard content (usual care), or content based on principles of social norming, anticipated regret, reciprocity, and commitment (behavioral content). MAIN OUTCOME MEASURES: Proportion of patients who completed HCV testing within four months. RESULTS: 21 303 patients were included in the intention-to-treat analysis. Among the 1642 patients in substudy A, 19.2% (95% confidence interval 16.5% to 21.9%) completed screening in the letter only arm and 43.1% (39.7% to 46.4%) in the letter+order arm (P<0.001). Among the 19 661 patients in substudy B, 14.6% (13.9% to 15.3%) completed screening with usual care content and 13.6% (13.0% to 14.3%) with behavioral science content (P=0.06). Among active patient portal users, 17.8% (16.0% to 19.5%) completed screening after receiving a letter and 13.8% (13.1% to 14.5%) after receiving a patient portal message (P<0.001). CONCLUSIONS: Opt out framing and effort reduction by including a signed laboratory order with outreach increased screening for HCV. Behavioral science messaging content did not increase uptake, and mailed letters achieved a greater response rate than patient portal messages. TRIAL REGISTRATION: ClinicalTrials.gov NCT03712553.


Assuntos
Controle Comportamental/métodos , Relações Comunidade-Instituição , Hepatite C/diagnóstico , Programas de Rastreamento/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Idoso , Método Duplo-Cego , Feminino , Seguimentos , Humanos , Masculino , Programas de Rastreamento/estatística & dados numéricos , Pessoa de Meia-Idade , Motivação , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Portais do Paciente , Pennsylvania , Serviços Postais , Atenção Primária à Saúde/estatística & dados numéricos , Resultado do Tratamento
12.
Artigo em Inglês | MEDLINE | ID: mdl-33946430

RESUMO

Bullying and victimization (BAV) have been widely studied, but the potential mechanism of parental behavioral control (PBC) on bullying and victimization in Chinese adolescents has not been explored. This study aimed to examine a moderated mediation model for the association between PBC and BAV mediated by deviant peer affiliation (DPA) and moderated by gender. A total of 3779 adolescents (Nboy = 1679, Mage = 14.98 years, SD = 0.95) from southwest China has completed the Peer Bullying, Peer Victimization, PBC, and DPA questionnaires. The results indicated that: (1) PBC significantly predicted adolescents' BAV (-12%); (2) DPA mediated the effect of PBC on BAV only for those adolescents who were both bullies and victims; (3) the mediating role of DPA was moderated by gender only in the relationship between PBC and victimization, with a relatively stronger effect in girls than in boys.


Assuntos
Bullying , Vítimas de Crime , Adolescente , Controle Comportamental , China/epidemiologia , Feminino , Humanos , Masculino , Grupo Associado
13.
Front Public Health ; 9: 662835, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34026716

RESUMO

Background: The coronavirus disease 2019 (COVID-19) is a highly contagious and potentially fatal infectious disease that has swept the globe. To reduce the spread, it is important to engage in preventive behaviors recommended by health authorities, such as washing your hands, wearing a face mask, and social distancing. Aim: In the present study, we draw from the Theory of Planned Behavior (TPB) to examine the associations between perceived behavioral control, attitudes, and subjective norm and whether people engage in eight different preventive behaviors. Methods: For each of the preventive behaviors (washing hands; using hand sanitizer; not touching your face; social distancing; wearing a face mask; disinfecting surfaces; coughing in your elbow; staying home if sick), we conducted separate logistic regressions predicting whether the participants (N = 2,256; age range = 1898 years) reported engaging in the behavior from their perceived behavioral control, attitudes, and subjective norm. Results: We found that perceived behavioral control, attitudes, and subjective norm had independent significant associations with each preventive behavior. Moderation analyses revealed that for most behaviors the associations with perceived behavioral control were stronger for older adults than for younger adults. Limitation: The present study was cross-sectional; future longitudinal studies and interventions are needed to disentangle directionality. Conclusion: Our findings suggest several ways to increase adherence to health behaviors that reduce the spread of coronavirus and other infectious diseases.


Assuntos
COVID-19 , Pandemias , Idoso , Atitude , Controle Comportamental , Estudos Transversais , Humanos , SARS-CoV-2
14.
Evol Psychol ; 19(1): 14747049211000714, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33752457

RESUMO

It is puzzling why countries do not all implement stringent behavioral control measures to prevent the spread of COVID-19 even though preventive behaviors have been proven to be the only effective means to stop the pandemic. We provide a novel evolutionary life history explanation whereby pathogenic and parasitic prevalence represents intrinsic rather than extrinsic mortality risk that drives slower life history strategies and the related disease control motivation in all animals but especially humans. Our theory was tested and supported based on publicly available data involving over 150 countries. Countries having a higher historical prevalence of infectious diseases are found to adopt slower life history strategies that are related to prompter COVID-19 containment actions by the government and greater compliance by the population. Findings could afford governments novel insight into the design of more effective COVID-19 strategies that are based on enhancing a sense of control, vigilance, and compliance in the general population.


Assuntos
Controle Comportamental , COVID-19 , Controle de Doenças Transmissíveis , Infecções , Traços de História de Vida , Comportamento de Redução do Risco , Controle Comportamental/legislação & jurisprudência , Controle Comportamental/métodos , Controle Comportamental/psicologia , COVID-19/epidemiologia , COVID-19/prevenção & controle , COVID-19/psicologia , Controle de Doenças Transmissíveis/métodos , Controle de Doenças Transmissíveis/tendências , Comportamento Cooperativo , Saúde Global , Regulamentação Governamental , Humanos , Infecções/epidemiologia , Infecções/psicologia , Infecções/transmissão , Prevalência , SARS-CoV-2 , Evolução Social
15.
Int J Behav Nutr Phys Act ; 18(1): 43, 2021 03 22.
Artigo em Inglês | MEDLINE | ID: mdl-33752697

RESUMO

BACKGROUND: Social factors are important determinants of youth physical activity (PA), but the longitudinal association between parental behaviours and adolescent PA has not been clearly assessed. This prospective study examined average and lagged associations between perceived parental support and control with adolescents' moderate to vigorous PA (MVPA); and assessed the independent associations between specific parental support and control behaviours and adolescents' MVPA. METHODS: Data from three cycles of the MATCH study, when 374 participants were 12, 16 and 17 years old, were included in this analysis. At each cycle, participants self-reported questionnaires on perceived tangible parental support, intangible support, and control behaviours as well as number of days per week attaining at least 60 min of MVPA. Mixed effect models were used to assess the longitudinal relationship between parental behaviours and MVPA. Cross-lagged panel design was used to assess the association of parental behaviours during early adolescence with MVPA during late adolescence. RESULTS: Overall parental support (coef. = 0.46, P < 0.0001), tangible support (coef. = 0.37, P < 0.0001), encouragement (coef. = 0.12, P = 0.025) and transportation (coef. = 0.25, P < 0.0001) were positively associated with MVPA, whereas parental control was a negative predictor of MVPA (coef. = - 0.18, P = 0.003). Perceived parental behaviours appeared to have long term associations (5 y.) with MVPA as parent support (coef. = 0.40, P = 0.006) and co-participation (coef. = 0.33, P = 0.017) reported around age 12 were positively associated with MVPA measured 5 years later. CONCLUSIONS: Parental support for PA, particularly in the form of tangible support, may be a key factor to include in interventions aiming to promote PA during adolescence. In contrast, parents should be encouraged to avoid control behaviours as these appear to lead to lower MVPA among adolescents.


Assuntos
Comportamento do Adolescente/psicologia , Exercício Físico/psicologia , Relações Pais-Filho , Poder Familiar/psicologia , Adolescente , Controle Comportamental/psicologia , Criança , Exercício Físico/fisiologia , Humanos , Estudos Longitudinais , Masculino , Pais/psicologia , Estudos Prospectivos , Autorrelato , Inquéritos e Questionários
16.
Med Sci Law ; 61(4): 275-285, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33715558

RESUMO

BACKGROUND: Restraint is widely practised within inpatient mental health services and is considered a higher-risk procedure for patients and staff. There is a sparsity of evidence in respect of the efficacy of personal protective equipment (PPE) used during restraint for reducing risk of infection. METHODS: A series of choreographed restraint episodes were used to simulate contact contamination in research participants playing the roles of staff members and a patient. For comparison, one episode of simulated recording of physical observations was taken. Ultraviolet (UV) fluorescent material was used to track the simulated contact contamination, with analysis undertaken using established image registration techniques of UV photographs. This was repeated for three separate sets of PPE. RESULTS: All three PPE sets showed similar performance in protecting against contamination transfer. For teams not utilising coveralls, this was dependent upon effective cleansing as part of doffing. There were similar patterns of contamination for restraint team members assigned to specific roles, with hands and upper torso appearing to be higher-risk areas. The restraint-related contamination was 23 times higher than that observed for physical observations. DISCUSSION: A second layer of clothing that can be removed showed efficacy in reducing contact contamination. PPE fit to individual is important. Post-restraint cleansing procedures are currently inadequate, with new procedures for face and neck cleansing required. These findings leave scope for staff to potentially improve their appearance when donning PPE and engaging with distressed patients.


Assuntos
COVID-19/transmissão , Pessoal de Saúde/educação , Controle de Infecções/métodos , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Equipamento de Proteção Individual/normas , Restrição Física , Treinamento por Simulação , Controle Comportamental , Humanos , Pacientes Internados , SARS-CoV-2 , Reino Unido/epidemiologia
17.
Nurs Health Sci ; 23(2): 325-336, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33605053

RESUMO

With an imperative to reduce or eliminate the use of coercive practices in mental health care it is important to understand the experience of service users and staff. This review aimed to synthesize qualitative studies, published between 1996 and 2020, reporting on mental health service users' and staff's experiences of chemical restraint. The databases PsycINFO, CINAHL, MEDLINE, Embase, Emcare, Web of Science, and Scopus were searched. Three analytic themes were identified from 17 included articles, synthesizing the experiences of service users and staff. These were "Unjustified versusjustified," "Violence versus necessity," and "Reflecting back: Positives and negatives." Service users viewed chemical restraint as an unjustified response to "behaviors of concern" and experienced it as a violent act with negative outcomes, although some saw it as necessary in retrospect and preferred it to other forms of coercion. Staff generally viewed it as a justified response to "behaviors of concern" and experienced it as appropriate within the constraints of staff numbers and limited alternatives. These findings identify nuances not apparent in the literature, which has generally conflated all forms of coercive practices.


Assuntos
Coerção , Serviços de Saúde Mental/estatística & dados numéricos , Tranquilizantes/uso terapêutico , Violência/prevenção & controle , Controle Comportamental/métodos , Humanos , Saúde Mental , Restrição Física
19.
Proc Natl Acad Sci U S A ; 118(6)2021 02 09.
Artigo em Inglês | MEDLINE | ID: mdl-33542099

RESUMO

Caenorhabditis elegans is used as a model system to understand the neural basis of behavior, but application of caged compounds to manipulate and monitor the neural activity is hampered by the innate photophobic response of the nematode to short-wavelength light or by the low temporal resolution of photocontrol. Here, we develop boron dipyrromethene (BODIPY)-derived caged compounds that release bioactive phenol derivatives upon illumination in the yellow wavelength range. We show that activation of the transient receptor potential vanilloid 1 (TRPV1) cation channel by spatially targeted optical uncaging of the TRPV1 agonist N-vanillylnonanamide at 580 nm modulates neural activity. Further, neuronal activation by illumination-induced uncaging enables optical control of the behavior of freely moving C. elegans without inducing a photophobic response and without crosstalk between uncaging and simultaneous fluorescence monitoring of neural activity.


Assuntos
Controle Comportamental , Caenorhabditis elegans/fisiologia , Caenorhabditis elegans/efeitos da radiação , Luz , Neurônios/fisiologia , Neurônios/efeitos da radiação , Animais , Fluorescência , Interneurônios/fisiologia , Regiões Promotoras Genéticas/genética , Canais de Cátion TRPV/agonistas , Canais de Cátion TRPV/metabolismo
20.
Ann Behav Med ; 55(7): 693-697, 2021 06 28.
Artigo em Inglês | MEDLINE | ID: mdl-33532817

RESUMO

BACKGROUND: Recent research has used the theory of planned behavior (TPB) to predict sleep. However, this research has focused on between-person effects and has failed to capture the intraindividual variability of sleep-related attitudes, subjective norms, perceived behavioral control, and intentions. PURPOSE: The current study sought to characterize the between- and within-day patterns of these constructs. METHODS: Participants (N = 79) completed a 1 week ecological momentary assessment protocol in which they reported their attitudes, subjective norms, perceived behavioral control, and intentions toward nightly sleep opportunity four times per day. RESULTS: Analyses revealed both between- and within-day variability of these constructs, with perceived behavioral control and intentions demonstrating greater variability than attitudes and subjective norms. Mixed linear models revealed that attitudes and subjective norms significantly increased throughout the week, while perceived behavioral control and intentions significantly decreased throughout the day. CONCLUSIONS: The between- and within-day patterns of the TPB constructs highlight important methodological considerations and provide insight into the potential refinement of sleep promotion efforts.


Assuntos
Atitude , Controle Comportamental/psicologia , Intenção , Teoria Psicológica , Sono , Variação Biológica Individual , Avaliação Momentânea Ecológica , Feminino , Humanos , Masculino , Adulto Jovem
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