Human health risk assessment of edible body parts of chicken through heavy metals and trace elements quantitative analysis.

Food safety and security have now been regarded as a significant emerging area within the food supply chain leading to scientific and public health concerns in the global world. The poultry sector is a substantial threat to heavy metal intoxication for Bangladeshi people due to contaminated drinking water and feed sources, as well as the poultry sector's surrounding environment and soil. This study was carried out to ascertain the residual concentrations of heavy metals (Pb, Cd) and trace elements (Cr, Fe, Cu, and Zn) in various edible chicken body parts (breast, liver, gizzard, heart, kidney, and brain) to observe the quality of the consumed chickens and to assess public health risk. Atomic absorption spectrometry (AAS) was used to check the content of toxic heavy metals and trace elements in 108 samples of 18 broiler chickens collected from six different locations of Dhaka North City Corporation markets in Bangladesh. The measured concentrations (mg/kg fresh weight) ranged from 0.33±0.2 to 4.6±0.4, 0.004±0.0 to 0.125±0.2, 0.006±0.0 to 0.94±0.4, 4.05±4.2 to 92.31±48.8, 0.67±0.006 to 4.15±2.7, and 4.45±0.62 to 23.75±4.3, for Pb, Cd, Cr, Fe, Cu, and Zn respectively. Except for Pb and Cu most of the investigated heavy metals and trace element levels in chickens were lower than the maximum allowable concentration (MAC) set by FAO/WHO and other regulatory agencies., The estimated level of Pb was nearly six times higher in the chicken brain. The estimated daily intake (EDI) values for all the studied metals were below the preliminary tolerated daily intake (PTDI). The target hazard quotient (THQ) values of the broiler chicken meat samples varied for adults and children, and the range was found to be 0.037-0.073 for Pb, 0.007-0.01 for Cd, 0.0-0.08 for Cr, 0.002-0.004 for Fe, for 0.00-0.002 Cu, and 0.004-0.008 for Zn, not exceeding the maximum level of 1 according to USEPA. The calculated THQ and total target hazard quotient (TTHQ) values were measured at less than one, suggesting that the consumption of chicken meat has no carcinogenic danger to its consumers. The Target carcinogenic risks (TCRs) of Pb, Cd, Cr, and Cu were within acceptable limits. The TCR values for children were, to some extent, higher than that of adults, which proposes that regular monitoring of both harmful and essential elements in chicken samples is necessary to determine whether or not any possible health risk to consumers exists. In terms of health, this study demonstrated that consumers are chronically exposed to elemental contamination with carcinogenic and non-carcinogenic effects.

Predicting Corrosion Damage in the Human Body Using Artificial Intelligence: In Vitro Progress and Future Applications.

Artificial intelligence (AI) is used in the clinic to improve patient care. While the successes illustrate AI's impact, few studies have led to improved clinical outcomes. In this review, we focus on how AI models implemented in nonorthopedic fields of corrosion science may apply to the study of orthopedic alloys. We first define and introduce fundamental AI concepts and models, as well as physiologically relevant corrosion damage modes. We then systematically review the corrosion/AI literature. Finally, we identify several AI models that may be implemented to study fretting, crevice, and pitting corrosion of titanium and cobalt chrome alloys.

Uranium oxides structural transformation in human body liquids.

Uranium oxide microparticles ingestion is one of the potential sources of internal radiation doses to the humans at accidental or undesirable releases of radioactive materials. It is important to predict the obtained dose and possible biological effect of these microparticles by studying uranium oxides transformations in case of their ingestion or inhalation. Using a combination of methods, a complex examination of structural changes of uranium oxides in the range from UO2 to U4O9, U3O8 and UO3 as well as before and after exposure of uranium oxides in simulated biological fluids: gastro-intestinal and lung-was carried out. Oxides were thoroughly characterized by Raman and XAFS spectroscopy. It was determined that the duration of expose has more influence on all oxides transformations. The greatest changes occurred in U4O9, that transformed into U4O9-y. UO2.05 and U3O8 structures became more ordered and UO3 did not undergo significant transformation.

The master role of polarized NIS expression in regulating iodine metabolism in the human body.

Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use of immunohistochemistry and polyclonal antibody against the C-terminal end of human NIS (hNIS). Results: Iodide absorption in the human intestine occurs via NIS expressed in the apical membrane. Iodide is secreted into the lumen of the stomach and salivary glands via NIS expressed in the basolateral membrane and then circulates back from the small intestine to the bloodstream via NIS expressed in the apical membrane. Conclusion: Polarized NIS expression in the human body regulates intestinal-bloodstream recirculation of iodide, perhaps prolonging the availability of iodide in the bloodstream. This leads to more efficient iodide trapping by the thyroid gland. Understanding the regulation and manipulating gastrointestinal iodide recirculation could increase radioiodine availability during theranostic NIS applications.

Multidimensional Profiling of Human Body Hairs Using Qualitative and Semi-Quantitative Approaches with SR-XRF, ATR-FTIR, DSC, and SEM-EDX.

This study aimed to assess the potential of a multidimensional approach to differentiate body hairs based on their physico-chemical properties and whether body hairs can replace the use of scalp hair in studies linked to forensic and systemic intoxication. This is the first case report controlling for confounding variables to explore the utility of multidimensional profiling of body hair using synchrotron synchrotron microbeam X-ray fluorescence (SR-XRF) for longitudinal and hair morphological region mapping) and benchtop methods, including attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) (complemented with chemometrics analysis), energy dispersive X-ray analysis (EDX) (complemented with heatmap analysis), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analysis (complemented by descriptive statistics) to profile different body hairs in terms of their elemental, biochemical, thermal, and cuticle properties. This multidimensional approach provided supportive information to emphasize the intricate and rather complex interplay between the organization and levels of elements and biomolecules within the crystalline and amorphous matrix of different body hairs responsible for the differences in physico-chemical properties between body hairs that are predominantly affected by the growth rate, follicle or apocrine gland activity, and external factors such as cosmetic use and exposure to environmental xenobiotics. The data from this study may have important implications for forensic science, toxicology and systemic intoxication, or other studies involving hair as a research matrix.

Performance Optimization of Wearable Printed Human Body Temperature Sensor Based on Silver Interdigitated Electrode and Carbon-Sensing Film.

The human body's temperature is one of the most important vital markers due to its ability to detect various diseases early. Accurate measurement of this parameter has received considerable interest in the healthcare sector. We present a novel study on the optimization of a temperature sensor based on silver interdigitated electrodes (IDEs) and carbon-sensing film. The sensor was developed on a flexible Kapton thin film first by inkjet printing the silver IDEs, followed by screen printing a sensing film made of carbon black. The IDE finger spacing and width of the carbon film were both optimized, which considerably improved the sensor's sensitivity throughout a wide temperature range that fully covers the temperature of human skin. The optimized sensor demonstrated an acceptable temperature coefficient of resistance (TCR) of 3.93 × 10-3 °C-1 for temperature sensing between 25 °C and 50 °C. The proposed sensor was tested on the human body to measure the temperature of various body parts, such as the forehead, neck, and palm. The sensor showed a consistent and reproducible temperature reading with a quick response and recovery time, exhibiting adequate capability to sense skin temperatures. This wearable sensor has the potential to be employed in a variety of applications, such as soft robotics, epidermal electronics, and soft human-machine interfaces.

A discomfort threshold for impulsive whole-body vibration on a slamming-prone vessel.

This study contributes towards a threshold for the onset of discomfort stemming from vibration that is transmitted to the human body by means of impulsive wave slamming in dynamic shipping environments. Wave slamming is a random, violent, non-linear event. Subjective and objective data were collected from two research voyages on a slamming-prone vessel. Full-scale vertical acceleration measurements were conducted near work and accommodation areas on the vessel. A daily diary survey was used to gather human responses among passengers. In addition, instantaneous slamming vibration comfort ratings were obtained by observers on the ship Bridge during a test sequence that purposefully induced slamming. The results indicate that two different approaches converged to the same VDV1hr comfort threshold (0.41 m/s1.75 and 0.43 m/s1.75), which corresponds to the limit where 50% of respondents indicated discomfort. A similar analysis using the r.m.s. metric converged to an identical threshold (0.03 m/s2), irrespective of the accumulated time of assessment.

Nanoparticle formulations: A smart era of advanced treatment with nanotoxicological imprints on the human body.

In the modern era, nanoparticles are the preferred dosage form, and maximum research is going on in the field of nanoparticle formulations. But as they are so small, nanoparticles are able to slip through the body's defenses and cause damage to the organs and tissues deep inside. In recent years, most researchers have focused solely on the therapeutic value of drugs or, at times, the performance of dosage forms, but few have given toxicity studies equal weight in their research. This review demonstrates that nanoparticle formulations are not suitable from a safety standpoint. So, researchers should be focused on alternative formulations like nanoemulsion, nanogel, and other liquids as well as semisolid formulations.

Effect of connection induced upper body movements on embodiment towards a limb controlled by another during virtual co-embodiment.

Even if we cannot control them, or when we receive no tactile or proprioceptive feedback from them, limbs attached to our bodies can still provide indirect proprioceptive and haptic stimulations to the body parts they are attached to simply due to the physical connections. In this study we investigated whether such indirect movement and haptic feedbacks from a limb contribute to a feeling of embodiment towards it. To investigate this issue, we developed a 'Joint Avatar' setup in which two individuals were given full control over the limbs in different sides (left and right) of an avatar during a reaching task. The backs of the two individuals were connected with a pair of solid braces through which they could exchange forces and match the upper body postures with one another. Coupled with the first-person view, this simulated an experience of the upper body being synchronously dragged by the partner-controlled virtual arm when it moved. We observed that this passive synchronized upper-body movement significantly reduced the feeling of the partner-controlled limb being owned or controlled by another. In summary, our results suggest that even in total absence of control, connection induced upper body movements synchronized with the visible limb movements can positively affect the sense of embodiment towards partner-controlled or autonomous limbs.

Looking at faces in the wild.

Faces are key to everyday social interactions, but our understanding of social attention is based on experiments that present images of faces on computer screens. Advances in wearable eye-tracking devices now enable studies in unconstrained natural settings but this approach has been limited by manual coding of fixations. Here we introduce an automatic 'dynamic region of interest' approach that registers eye-fixations to bodies and faces seen while a participant moves through the environment. We show that just 14% of fixations are to faces of passersby, contrasting with prior screen-based studies that suggest faces automatically capture visual attention. We also demonstrate the potential for this new tool to help understand differences in individuals' social attention, and the content of their perceptual exposure to other people. Together, this can form the basis of a new paradigm for studying social attention 'in the wild' that opens new avenues for theoretical, applied and clinical research.

Do Changes in the Body-Part Compatibility Effect Index Tool-Embodiment?

Tool-embodiment is said to occur when the representation of the body extends to incorporate the representation of a tool following goal-directed tool-use. The present study was designed to determine if tool-embodiment-like phenomenon emerges following different interventions. Participants completed body-part compatibility task in which they responded with foot or hand presses to colored targets presented on the foot or hand of a model, or on a rake held by the model. This response time (RT) task was performed before and after one of four interventions. In the Virtual-Tangible and the Virtual-Keyboard interventions, participants used customized controllers or keyboards, respectively, to move a virtual rake and ball around a course. Participants in the Tool-Perception intervention manually pointed to targets presented on static images of the virtual tool-use task. Participants in the Tool-Absent group completed math problems and were not exposed to a tool task. Results revealed that all four interventions lead to a pattern of pre-/post-intervention changes in RT thought to indicate the emergence of tool-embodiment. Overall, the study indicated that tool-embodiment can occur through repeated exposure to the body-part compatibility paradigm in the absence of any active tool-use, and that the paradigm may tap into more than just body schema.

An optimized method for neutron dose evaluation based on24Na activity distribution in the human body.

The neutron dose resulting from external irradiation can be evaluated by measuring the counts of characteristicγrays produced by24Na in the human body. The detection geometry with the highest detection efficiency for measuring the whole-body24Na activity has not been studied. In this work, the MCNP code is used to calculate the spatial distribution of24Na in the human body irradiated by neutrons with different energies in different irradiation geometries. The fluence distribution of24Na characteristicγrays on the body surface is calculated. The counts of24Na characteristicγrays induced by monochromatic neutron irradiation are simulated to fit the scenarios of neutron irradiation by a continuous energy spectrum neutron. When the spontaneous neutrons from252Cf with 1Gy dose irradiate the human body, (3.63-4.35) × 1010 24Na atoms are produced. The lower detection limit for the neutron absorption dose is reduced from ∼100 to less than 1 mGy when the radiation detector is placed over the back of the human body close to the liver. The relative error between the measured counts of24Na characteristic γ rays caused by252Cf neutron irradiation and the counts fitted by monochromatic neutron irradiation data is less than 5.7%. The neutron dose received from a continuous energy spectrum neutron can be acquired quickly and accurately by weighted summing of the data for monochromatic neutron irradiations calculated in this paper, which is more convenient and practical than the previous method.

Experimental Procedure for the Metrological Characterization of Time-of-Flight Cameras for Human Body 3D Measurements.

Time-of-flight cameras are widely adopted in a variety of indoor applications ranging from industrial object measurement to human activity recognition. However, the available products may differ in terms of the quality of the acquired point cloud, and the datasheet provided by the constructors may not be enough to guide researchers in the choice of the perfect device for their application. Hence, this work details the experimental procedure to assess time-of-flight cameras' error sources that should be considered when designing an application involving time-of-flight technology, such as the bias correction and the temperature influence on the point cloud stability. This is the first step towards a standardization of the metrological characterization procedure that could ensure the robustness and comparability of the results among tests and different devices. The procedure was conducted on Kinect Azure, Basler Blaze 101, and Basler ToF 640 cameras. Moreover, we compared the devices in the task of 3D reconstruction following a procedure involving the measure of both an object and a human upper-body-shaped mannequin. The experiment highlighted that, despite the results of the previously conducted metrological characterization, some devices showed evident difficulties in reconstructing the target objects. Thus, we proved that performing a rigorous evaluation procedure similar to the one proposed in this paper is always necessary when choosing the right device.

Random allelic expression in the adult human body.

Genes are typically assumed to express both parental alleles similarly, yet cell lines show random allelic expression (RAE) for many autosomal genes that could shape genetic effects. Thus, understanding RAE in human tissues could improve our understanding of phenotypic variation. Here, we develop a methodology to perform genome-wide profiling of RAE and biallelic expression in GTEx datasets for 832 people and 54 tissues. We report 2,762 autosomal genes with some RAE properties similar to randomly inactivated X-linked genes. We found that RAE is associated with rapidly evolving regions in the human genome, adaptive signaling processes, and genes linked to age-related diseases such as neurodegeneration and cancer. We define putative mechanistic subtypes of RAE distinguished by gene overlaps on sense and antisense DNA strands, aggregation in clusters near telomeres, and increased regulatory complexity and inputs compared with biallelic genes. We provide foundations to study RAE in human phenotypes, evolution, and disease.

Polycyclic aromatic hydrocarbons (PAHs): Updated aspects of their determination, kinetics in the human body, and toxicity.

Polycyclic aromatic hydrocarbons (PAHs) are legacy pollutants of considerable public health concern. Polycyclic aromatic hydrocarbons arise from natural and anthropogenic sources and are ubiquitously present in the environment. Several PAHs are highly toxic to humans with associated carcinogenic and mutagenic properties. Further, more severe harmful effects on human- and environmental health have been attributed to the presence of high molecular weight (HMW) PAHs, that is PAHs with molecular mass greater than 300 Da. However, more research has been conducted using low molecular weight (LMW) PAHs). In addition, no HMW PAHs are on the priority pollutants list of the United States Environmental Protection Agency (US EPA), which is limited to only 16 PAHs. However, limited analytical methodologies for separating and determining HMW PAHs and their potential isomers and lack of readily available commercial standards make research with these compounds challenging. Since most of the PAH kinetic data originate from animal studies, our understanding of the effects of PAHs on humans is still minimal. In addition, current knowledge of toxic effects after exposure to PAHs may be underrepresented since most investigations focused on exposure to a single PAH. Currently, information on PAH mixtures is limited. Thus, this review aims to critically assess the current knowledge of PAH chemical properties, their kinetic disposition, and toxicity to humans. Further, future research needs to improve and provide the missing information and minimize PAH exposure to humans.

Dried fish more prone to microplastics contamination over fresh fish - Higher potential of trophic transfer to human body.

Globally, microplastics (MPs) contamination in aquatic organisms is emerging as an alarming phenomenon. In the present study, we investigated MPs in three commercially important fishes (Bombay duck Harpadon nehereus, ribbon fish Trichiurus lepturus and hairfin anchovy Setipinna phasa) in fresh and dried conditions collected from two sites (Chattogram and Kuakata) of the Bay of Bengal. It was evident that fresh T. lepturus ingested highest amount of MPs through the gills (6.41 mps/g) from Chattogram followed by in the gastrointestinal tract, GIT (6.20 mps/g) and in the muscle (1.20 mps/g) from Kuakata. Among the fresh fishes, H. nehereus from Kuakata accumulated highest amount of MPs (0.21 mps/g), while S. phasa from Kuakata contained the least amount of MPs (0.06 mps/g). On the other hand, among the dried fishes, T. lepturus from Kuakata contained highest amount of MPs (46.00 mps/g), while S. phasa from Kuakata retained lowest amount of MPs (2.17 mps/g). Strangely, all the dried fishes showed significantly higher amount of MPs compared to fresh fishes from both the locations. Fiber was the most dominant type of shape of MPs which accounted 66 %, followed by fragment (27.38 %), microbeads (3.59 %), film (1.48 %), foam (1.31 %) and pellet (0.25 %). Size-wise, the major portion (39.66 %) of MPs was present to be in size range less than 0.5 mm followed by 37.67 % in the size range of 0.5-1.0 mm group and rest 22.67 % within 1.0-5.0 mm. Red (41.55 %) colored MPs was the most prominent, followed by brown (22.11 %), blue (16.32 %), pink (11.69 %), purple (5.10 %), and green (2.25 %). Among polymer types, low-density polyethylene (LDPE) was the most common (38 %), followed by polystyrene (PS-22 %), polyvinyl chloride (PVC-16 %), polyamide (PA-13 %) and ethylene-vinyl acetate (EVA-9 %). The present study confirms high occurrence of MPs in the dried fishes over the fresh fishes from the Bay of Bengal, with high potential of trophic transfer to the human body.

Thermal response of human body with immersion suit in cold environment.

Hypothermia caused by cold water immersion is one of the main causes of death in marine accidents. Immersion suit is a kind of protective clothing when implementing flying tasks over the sea in cold seasons, with the main function to slow down the loss of human heat in water and prolong the survival time. In this study, the thermal properties and wearing types of immersion suit and underwear were analyzed. The subjects with internal- and external-wear immersion suit exposed to the experimental environments for 2 h in five working conditions. The core temperature, weighted average skin temperature, and average body temperature were measured and calculated. Both internal- and external-wear immersion suits could fulfil the cold protection requirements under the experimental conditions. The results of clothing parameter tests and physiological experiments both exhibit that the external-wear immersion suit has better thermal insulation effect. And the tolerance time in low-temperature water was predicted, which is crucial for effective and efficient rescue during shipwreck in adverse thermal scenarios. In future research, a comprehensive evaluation and analysis of the thermal insulation performance of immersion suit could be completed in combination with the water ingress of the clothing, the subjects' thermal comfort, and flexibility of the clothing.

A large-scale brain network of species-specific dynamic human body perception.

This ultrahigh field 7 T fMRI study addressed the question of whether there exists a core network of brain areas at the service of different aspects of body perception. Participants viewed naturalistic videos of monkey and human faces, bodies, and objects along with mosaic-scrambled videos for control of low-level features. Independent component analysis (ICA) based network analysis was conducted to find body and species modulations at both the voxel and the network levels. Among the body areas, the highest species selectivity was found in the middle frontal gyrus and amygdala. Two large-scale networks were highly selective to bodies, dominated by the lateral occipital cortex and right superior temporal sulcus (STS) respectively. The right STS network showed high species selectivity, and its significant human body-induced node connectivity was focused around the extrastriate body area (EBA), STS, temporoparietal junction (TPJ), premotor cortex, and inferior frontal gyrus (IFG). The human body-specific network discovered here may serve as a brain-wide internal model of the human body serving as an entry point for a variety of processes relying on body descriptions as part of their more specific categorization, action, or expression recognition functions.

Numerical simulation of social distancing of preventing airborne transmission in open space with lateral wind direction, taking into account temperature of human body and floor surface.

This paper presents the numerical results of particle propagation in open space, taking into account the temperature of the human body and the surface of the ground. And also, the settling of particles or droplets under the action of gravitational force and transport in the open air is taken into account, taking into account the temperature during the process of breathing and sneezing or coughing. The temperature of the body and the surface of the ground, different rates of particle emission from the mouth, such as breathing and coughing or sneezing, are numerically investigated. The effect of temperature, cross-inlet wind, and the velocity of particle ejection from a person's mouth on social distancing is being investigated using a numerical calculation. The variable temperature of the human body forms a thermal plume, which affects the increase in the trajectory of the particle propagation, taking into account the lateral air flow. The thermal plume affects the particles in the breathing zone and spreads the particles over long distances in the direction of the airflow. The result of this work shows that in open space, taking into account the temperature of the body and the surface of the ground, a 2-m social distance may be insufficient for the process of sneezing and social distance must be observed depending on the breathing mode.

Fractal Dynamics in a Whole-Body Dynamic Balance Sport, Slacklining: A Comparison of Novices and Experts.

The present study investigated whether fractal dynamics can be observed during single-leg standing on a slackline. We also examined whether the temporal structure differs with skill level. To address these questions, we compared single-leg standing performance between novices (N=5) and experts (N=5) in terms of fractal dynamics in both ankles (i.e., stance and swing legs), center of mass, and head acceleration time series using detrended fluctuation analysis. Participants were required to perform single-leg standing on a slackline. To collect motion data while slacklining, we used a three-dimensional motion capture system and obtained time-series data on the position. We conducted detrended fluctuation analysis on the original acceleration time series and random shuffled time series to examine the fractal dynamics in each body part's fluctuation. Results suggest that experts showed persistent temporal structure in the swinging leg, center of mass, and head fluctuations in the horizontal direction, while that of novices did not differ from random fluctuations. These findings revealed that experts performing a single-leg standing task on a slackline show fractal dynamics. This might reflect their flexible or adaptive exploratory behavior in the performer-environment system and contribute to the dynamic stability of whole-body dynamic balancing.