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1.
Invest Ophthalmol Vis Sci ; 60(14): 4882-4888, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31752017

RESUMO

Purpose: To describe the morphological features of posterior precortical vitreous pockets (PPVP) and Cloquet's Canal in patients with myopia using swept-source optical coherence tomography (SS OCT). Methods: A total of 96 eyes of 51 volunteers (range, 5-18 years) were enrolled in this study, and all individuals underwent OCT (Optovue Inc., Fremont, CA, USA) examinations. From the collected PPVPs images, the widths and heights of the PPVPs were measured, and connections between PPVPs and Cloquet's Canal were identified. The PPVPs widths and heights, width:height ratios and proportions of connections were compared among different age (5-8, 9-14, 15-18 years), axial length (AL; 21-23, 23-25, 25-29 mm) and myopia groups (hyperopia, low to moderate myopia, high myopia); the group data were analyzed to determine their relationship with myopia. Results: PPVPs were identified in 89 of 96 eyes; 6 eyes were excluded for poor image quality. The PPVPs width was positively correlated with age, especially in the low to moderate myopia group (F = 7.715, P = 0.001). There was a significant difference in the PPVPs height between the refractive error groups in the 9 to 14 years group (F = 4.905, P = 0.005). The PPVPs width:height ratio was different among the refractive error groups in the 9 to 14 years group (F = 3.335, P = 0.041) and among the different age groups in the low to moderate myopia group (F = 6.077, P = 0.004). A total of 22 eyes (22.4%) were identified as having a connection between the PPVP and Cloquet's Canal. The connections began to increase with AL at 5 to 8 years (χ2 = 7.363, P = 0.025). Conclusions: PPVPs existed in most myopia patients from 5 to 18 years old. PPVPs width was positively correlated with age, especially in the low to moderate myopia group. PPVPs height decreased in the 9 to 14 years group with myopia. An imbalance in the horizontal and vertical enlargement of PPVP was the main feature in the 9- to 14-year-old group with myopia. The connections between the PPVP and Cloquet's Canal were associated with AL extension in the 5- to 8-year-old group.


Assuntos
Oftalmopatias/diagnóstico , Miopia/diagnóstico , Corpo Vítreo/patologia , Adolescente , Envelhecimento/fisiologia , Criança , Pré-Escolar , Progressão da Doença , Oftalmopatias/diagnóstico por imagem , Feminino , Humanos , Masculino , Tomografia de Coerência Óptica/métodos , Corpo Vítreo/diagnóstico por imagem
3.
Curr Opin Ophthalmol ; 30(6): 491-499, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31589186

RESUMO

PURPOSE OF REVIEW: Vitreoretinal lymphoma (VRL) is well known as a masquerade syndrome. However, delays in diagnosis are common particularly because of the small volume of tissue that is used for investigative studies. We outline the current diagnostic tests available to clinicians and provide a glimpse of possible future novel diagnostics. RECENT FINDINGS: The use of spectral domain ocular coherence tomography to identify subretinal lesions has proven to be a reliable ally to clinicians. Nevertheless, the diagnostic gold standard remains cytology, which requires a skilled pathologist. Molecular tests, including MYD88 polymerase chain reaction testing has further refined our diagnostic capabilities. Metagenomic deep sequencing is a newer molecular test that offers the ability to identify any mutation associated with lymphoma development and may offer more sensitive testing in the future. SUMMARY: Clinicians have developed a strong acumen for suspecting VRL based upon clinical features, which can further be supported by a variety of imaging modalities. Delays in diagnosis continue to occur particularly because of the small volume of ocular fluid available for testing and because current tests offer a biased approach in terms of limited scope of detecting a specific mutation or cytopathologic feature(s). Newer molecular techniques feature an expanded scope of detecting any mutation associated with lymphomatous development.


Assuntos
Neoplasias Oculares/diagnóstico , Linfoma Intraocular/diagnóstico , Neoplasias da Retina/diagnóstico , Corpo Vítreo/patologia , Neoplasias Oculares/genética , Humanos , Linfoma Intraocular/genética , Técnicas de Diagnóstico Molecular , Fator 88 de Diferenciação Mieloide/genética , Neoplasias da Retina/genética
4.
Turk J Ophthalmol ; 49(4): 209-212, 2019 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-31486608

RESUMO

Objectives: To investigate the frequency of retinal tear, retinal hole, and lattice degeneration in peripheral retinal examination of patients with macular hole. Materials and Methods: The files of patients who underwent pars plana vitrectomy surgery with a diagnosis of macular hole at Eskisehir Osmangazi University Department of Ophthalmology between 2008 and 2018 were retrospectively analyzed. A total of 106 patients with primary macular hole who underwent peripheral retinal examination were included in the study. The frequency of retinal tears, holes, and lattice degeneration associated with macular hole was investigated. Results: Peripheral retinal examination of 106 patients who underwent macular hole surgery revealed retinal tear in 3 patients (2.8%), retinal hole in 4 patients (3.8%), and lattice degeneration in 10 patients (9.4%). Retinal hole and lattice degeneration were observed concomitantly in 1 patient. Conclusion: This study showed that patients with macular hole have concomitant retinal tears and holes, which are also thought to arise due to vitreoretinal traction, at a frequency similar to that in the general population. This result suggests that both the anterior and posterior vitreous may have different pathologies at the same time related to these diseases.


Assuntos
Degeneração Retiniana/epidemiologia , Descolamento Retiniano/epidemiologia , Perfurações Retinianas/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Perfurações Retinianas/epidemiologia , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual , Corpo Vítreo/patologia
5.
Graefes Arch Clin Exp Ophthalmol ; 257(11): 2349-2356, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31446460

RESUMO

PURPOSE: To determine the underlying reasons for the non-visualization of polyps on en face optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV). METHODS: A cross-sectional study of consecutive treatment-naïve 30 eyes with active PCV was included. Results of fundus photography, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT), and en face OCTA were analyzed. RESULTS: A total of 64 active polyps were found on FFA and ICGA in 30 eyes. On OCTA, 42/64 (65.6%) polyps were visualized, while 22/64 (34.4%) polyps were non-visualized. There were no significant differences in the size (P = 0.723) and filling time of polyps (P = 0.558) between the two groups. However, polypoidal lesions were less common in the non-visualized group (P < 0.001). The height of the polyps on SD-OCT was 243.95 ± 114.24 µm in the non-visualized group, which was higher than those (188.00 ± 87.93 µm) in the visualized group (P = 0.048). Moreover, more pulsatile polyps (72.7%) were found in the non-visualized group than those (2.4%) in the visualized group (P < 0.001). Four of the 22 polyps in the non-visualized group (18.2%) were located under a thick subretinal hemorrhage, and two of 22 invisible polyps (9.6%) located under and parallel to the retinal vessel in the inner layer of retina. CONCLUSIONS: Our results revealed that the height of the polyps, and not the size and pulsation of the polyps, correlated with the visualization of the polyps on OCTA. Polyps that were pulsating in early ICGA were difficult to be visualized on OCTA, which is the most possible reason for the non-visualization. Coverage with thick subretinal hemorrhage or retina vessels was another reason for the non-visualization of the polyps in active PCV on OCTA.


Assuntos
Angiofluoresceinografia/métodos , Pólipos/diagnóstico , Vasos Retinianos/patologia , Tomografia de Coerência Óptica/métodos , Corpo Vítreo/irrigação sanguínea , Idoso , Doenças da Coroide/diagnóstico , Estudos Transversais , Feminino , Seguimentos , Fundo de Olho , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Corpo Vítreo/patologia
7.
Graefes Arch Clin Exp Ophthalmol ; 257(10): 2137-2146, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31324966

RESUMO

PURPOSE: To investigate the prevalence and progression of vitreo-macular interface disorders (VMID) phenotypes and their natural history in retinitis pigmentosa (RP). METHODS: A total of 257 eyes of 145 RP patients with VMID were retrospectively evaluated. Patients were divided according to the VMID subtypes into epiretinal membranes (ERMs), vitreo-macular traction (VMT) group, and macular hole (MH). Serial eye-tracked spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA) changes were analyzed for a mean follow-up of 36.95 months. The status of posterior vitreous cortex was also considered. A control group of 65 eyes belonging to 65 RP patients with no macular changes was also recruited. RESULTS: VMID and control groups had the same baseline BCVA (0.50 vs 0.44 LogMAR) and did not differ in terms of phakic status. Different VMID groups had similar BCVA at baseline (p = 0.98). ERM represented the most prevalent disorder (207/257 eyes, 80.5%), followed by 35/257 (13.6%) VMT, and 15/257 Lamellar MH (LMH) eyes (5.8%). There were no cases of full thickness MH. Throughout the 36.9 months of follow-up, BCVA decreased an average 0.09 LogMAR from 0.31 to 0.4 in VMID patients and 0.01 in controls. VMID subgroup analysis showed a significant BCVA decrease in ERM patients (- 20.29%, p < 0.001), while VMT and LMH did not change significantly. Foveal thickness also remained stable over time. Complete PVD was present in 11 eyes in ERM, VMT, and LMH. CONCLUSIONS: Our study confirms the high prevalence of VMID in RP patients; however, only ERMs determined a significant loss of vision over 24 months. The high prevalence of VMID in RP patients suggests that macular alteration other than edema represents part of disease spectrum.


Assuntos
Membrana Epirretiniana/epidemiologia , Macula Lutea/patologia , Perfurações Retinianas/epidemiologia , Retinite Pigmentosa/diagnóstico , Tomografia de Coerência Óptica/métodos , Acuidade Visual , Corpo Vítreo/patologia , Membrana Epirretiniana/diagnóstico , Membrana Epirretiniana/etiologia , Feminino , Seguimentos , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/etiologia , Retinite Pigmentosa/complicações , Estudos Retrospectivos
10.
Ophthalmologica ; 242(2): 98-105, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31220838

RESUMO

PURPOSE: The purpose of this study was to investigate the efficacy and safety of surgically induced macular detachment (MD) for the treatment of refractory full-thickness macular hole (FTMH). MATERIALS AND METHODS: Clinical data were age, gender, lens status, and best corrected visual acuity (BCVA). Preoperative tomographic parameters were: FTMH morphology (intraretinal cyst and elevated or flat edges) and FTMH diameter. Postoperative FTMH closure and outer retinal layer (ORL) restoration were evaluated. Fundus autofluorescence (FAF), optical coherence tomography (OCT) findings, and BCVA were analyzed at the 1st, 3rd, and 6th postoperative month. The interval between the first surgery for idiopathic FTMH and the surgically induced MD for refractory FTMH was collected (intersurgical interval, days). RESULTS: Ten eyes of 10 patients were included. The mean age was 68.8 ± 6.8 years. FTMH closure was obtained in 9 patients; in 8 patients, ORL restoration was detected. BCVA improved from 1.06 ± 0.1 (baseline) to 0.56 ± 0.2 (final) logMAR (p = 0.0001). A negative correlation between the intersurgical interval and postoperative visual gain was demonstrated (r = -0.3618). FAF and OCT showed a permanent retinal pigment epithelium (RPE) damage corresponding to the retinotomy points. CONCLUSION: This study demonstrates the efficacy of this technique and highlights the risk of RPE damage, suggesting the need to perform the retinotomy points outside the macula.


Assuntos
Macula Lutea/cirurgia , Descolamento Retiniano/etiologia , Perfurações Retinianas/cirurgia , Tomografia de Coerência Óptica/métodos , Acuidade Visual , Vitrectomia/métodos , Idoso , Tamponamento Interno/métodos , Feminino , Humanos , Período Intraoperatório , Macula Lutea/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Descolamento Retiniano/diagnóstico , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/fisiopatologia , Estudos Retrospectivos , Corpo Vítreo/patologia
11.
PLoS One ; 14(6): e0218433, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31216331

RESUMO

PURPOSE: Vitreous vitamin C, as an anti-oxidant, is responsible for regulating oxygen tension and oxidative stress in the eye. Oxidative stress and retinal ischemia are implicated in the development of proliferative diabetic retinopathy (PDR). In this study, we aimed to determine whether vitreous level of vitamin C is compromised in patients with PDR and to investigate the association of diabetic macular ischemia and vitamin C. METHODS: This prospective study enrolled forty patients who underwent pars plana vitrectomy for the treatment of PDR (PDR group, n = 20) and idiopathic epiretinal membrane (control group, n = 20). Serum, aqueous humor, and the vitreous were collected for the analysis of vitamin C level by HPLC. Diabetic macular ischemia (DMI) in PDR group was evaluated with fluorescein angiography (FA). RESULTS: PDR patients (60.4 ± 2.1 y) were younger than non-diabetic control patients (67.4 ± 1.2 y). Serum, aqueous, and vitreous levels of vitamin C in PDR were 38.7%, 22.5%, and 11.1% of non-diabetic control group, respectively. All PDR patients had DMI (grade 1: 25%, grade 2: 30%, grade 3: 30%, grade 4: 15%). DMI grade was inversely correlated with the level of vitreous vitamin C (r = -0.546, P = 0.019), not with HbA1C, serum, or aqueous vitamin C level. In addition, the level of vitreous vitamin C (4.5 ± 2.6 µg/ml) in high DMI group (Gr 3 &4) was lower than that (31.0 ± 9.1 µg/ml) in low DMI group (Gr 1&2) (P = 0.015). CONCLUSIONS: Vitreous level of vitamin C in PDR patients showed a tenfold decrease, which was associated with the degree of macular ischemia. This suggests that vitreous vitamin C depletion may cause macula ischemia in PDR patients.


Assuntos
Antioxidantes/uso terapêutico , Ácido Ascórbico/metabolismo , Diabetes Mellitus Tipo 2/tratamento farmacológico , Retinopatia Diabética/tratamento farmacológico , Idoso , Humor Aquoso/metabolismo , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/patologia , Diabetes Mellitus Tipo 2/cirurgia , Retinopatia Diabética/patologia , Retinopatia Diabética/cirurgia , Membrana Epirretiniana/tratamento farmacológico , Membrana Epirretiniana/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Vitrectomia , Corpo Vítreo/metabolismo , Corpo Vítreo/patologia
12.
BMC Ophthalmol ; 19(1): 126, 2019 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-31176357

RESUMO

BACKGROUND: To delineate the characteristics of complicated familial exudative vitreoretinopathy (FEVR) patients diagnosed before surgery or intra-/post-operatively and to analyze the risk factors for the diagnostic timing. METHODS: Forty-eight patients who underwent surgery and were diagnosed as FEVR in our department were retrospectively reviewed. Data were collected including the demographic and clinical characteristics of these patients. FEVR patients were divided into 2 groups according to the diagnostic timing: FEVR diagnosed pre-operatively (23 patients), FEVR diagnosed intra-/post-operatively (25 patients). Multivariable analysis was applied for analyzing the risk factors for diagnostic timing. RESULTS: The clinical characteristics of the FEVR patients were of great variability, including retinal detachment (RD), disappear of anterior chamber, retrolental membrane, epiretinal membrane (ERM), vitreous hemorrhage (VH), myopic foveoschisis (MF), lamellar macular hole (LMH), high myopia (HM). And the referral diagnosis or pre-operative diagnosis were always non-specific. The majority of the referral or preoperative diagnosis were unilateral RD (52.1%), bilateral RD (8.3%), unilateral persistent fetal vasculature (PFV) (8.3%), bilateral PFV (4.2%). There are two risk factors for the complicated FEVR cases diagnosed as FEVR preoperatively: pre-operative ocular manifestations with RD only (OR, 0.104; p-value, 0.022), positive parent's fluorescein angiography (FA) (OR, 0.105; p-value, 0.035). CONCLUSIONS: The phenotypes of FEVR were greatly variable, they can mimic many non-specific vitreoretinal disorders. The most non-specific referral diagnosis/pre-operative diagnosis was unilateral RD, bilateral RD, unilateral PFV, bilateral PFV. A positive family history or a simple ocular presentation with RD only could contribute to diagnose FEVR preoperatively.


Assuntos
Diagnóstico Precoce , Oftalmopatias Hereditárias/diagnóstico por imagem , Angiofluoresceinografia/métodos , Oftalmoscopia/métodos , Retina/patologia , Doenças Retinianas/diagnóstico por imagem , Cirurgia Vitreorretiniana/métodos , Corpo Vítreo/patologia , Adolescente , Adulto , Criança , Pré-Escolar , Diagnóstico Diferencial , Oftalmopatias Hereditárias/cirurgia , Feminino , Seguimentos , Fundo de Olho , Humanos , Lactente , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Período Pré-Operatório , Doenças Retinianas/cirurgia , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
14.
Graefes Arch Clin Exp Ophthalmol ; 257(8): 1631-1639, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31104140

RESUMO

PURPOSE: To develop a new classification system for vitreomacular traction (VMT) syndrome according to spectral-domain optical coherence tomography (SD-OCT) imaging and to investigate the clinical course of VMT patients. METHODS: This study included 68 eyes of 68 consecutive patients who were followed with observation or treated with vitrectomy for idiopathic VMT. Eyes were classified into one of three groups according to SD-OCT findings: group A (foveal pseudocyst, which was defined as the formation of cystoid cavity located in the inner part of the central fovea along with foveal thickening), group B (parafoveal retinoschisis, which was defined as intraretinal cysts or clefts along with no apparent foveal thickening), and group C (outer retinal dehiscence at the fovea, which is sometimes accompanied by foveal thinning). The minimum required follow-up period was 1 year. Clinical course and anatomical and functional outcomes were compared among the groups. RESULTS: Twenty-seven eyes (39.7%) were included in group A, 22 eyes (32.4%) were included in group B, and 19 eyes (27.9%) were included in group C. Among the 24 eyes that were managed by observation, a significantly larger percentage of patients in group A (6/10 [60%]) exhibited more spontaneous resolution of VMT compared with those in groups B (9.1%) or C (0%) (P = 0.010). In the 44 eyes that were managed with vitrectomy, a significantly larger percentage of patients in group C (4/16 [25%]) experienced subsequent full-thickness macular hole development following vitrectomy compared with those in groups B (0%) or C (0%) (P = 0.014). The percentage of patients with photoreceptor inner segment/outer segment disruption was significantly reduced in group A after vitrectomy, with group C exhibiting the lowest recovery rate. Postoperatively, group A experienced a significantly better visual outcome than group C (P = 0.021). CONCLUSIONS: A novel configuration system offering insight into the clinical course of VMT is proposed. According to this system, anatomical and functional outcomes were favorable in group A and worse in group C.


Assuntos
Retina/patologia , Doenças Retinianas/diagnóstico , Tomografia de Coerência Óptica/métodos , Acuidade Visual , Vitrectomia/métodos , Corpo Vítreo/patologia , Descolamento do Vítreo/diagnóstico , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Retinianas/cirurgia , Estudos Retrospectivos , Síndrome , Resultado do Tratamento , Descolamento do Vítreo/cirurgia
16.
Indian J Ophthalmol ; 67(6): 785-787, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31124487

RESUMO

Purpose: To study the clinicopathological findings of Persistent Fetal Vasculature (PFV) in patients with congenital cataract and PFV. Methods: Six eyes with anterior or combined PFV with cataract underwent phacoaspiration with primary posterior capsulotomy with anterior vitrectomy with intraocular lens implantation followed by histopathological evaluation of the PFV stalk and membrane. Results: Four and two patients had combined and anterior PFV respectively. There was no postoperative hyphema, vitreous haemorrhage, glaucoma or retinal detachment in six months. Haematoxylin and eosin staining showed inflammatory cells predominantly with extramedullary hematopoeisis and vascularisation. Conclusion: We recommend IOL implantation in PFV, with early and aggressive amblyopia therapy.


Assuntos
Vítreo Primário Hiperplásico Persistente/diagnóstico , Vitrectomia/métodos , Corpo Vítreo/patologia , Catarata/congênito , Seguimentos , Humanos , Lactente , Recém-Nascido , Lentes Intraoculares , Masculino , Microscopia Acústica , Vítreo Primário Hiperplásico Persistente/terapia , Facoemulsificação , Prognóstico , Estudos Prospectivos , Corpo Vítreo/cirurgia
17.
Arq Bras Oftalmol ; 82(4): 317-321, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31038555

RESUMO

PURPOSE: To evaluate ophthalmic ultrasonographic findings associated with active ocular toxoplasmosis. METHODS: Forty-seven eyes with active ocular toxoplasmosis in 47 patients were subjected to ocular ultrasonography using the transpalpebral technique (10-MHz transducer) and fundus photography. Patient medical records were retrospectively reviewed. RESULTS: Ocular ultrasonography revealed vitritis, posterior vitreous detachment, retinal wall thickening, and non-rhegmatogenous retinal detachment in 47 (100%), 36 [76.6%; partial in 12 (25.5%) and total in 23 (48.9%)], 12 (25.5%), and 5 eyes (10.6%). Thirty-five of the 36 eyes with posterior vitreous detachment (97.2%) exhibited posterior hyaloid thickening; moreover, adhesion to the exudative lesion and vitreoschisis were observed in 4 (11.1%) and 12 eyes (25.5%), respectively. Ultrasonography detected the location of the exudative focus in 12 eyes (25.5%). CONCLUSION: Ultrasonography is helpful for detecting important intraocular findings of acute ocular toxoplasmosis that can be hindered by medial opacity or posterior synechiae.


Assuntos
Toxoplasmose Ocular/diagnóstico por imagem , Toxoplasmose Ocular/patologia , Ultrassonografia/métodos , Adolescente , Adulto , Idoso , Coriorretinite/diagnóstico por imagem , Coriorretinite/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Descolamento Retiniano/diagnóstico por imagem , Descolamento Retiniano/patologia , Uveíte/diagnóstico por imagem , Uveíte/patologia , Corpo Vítreo/diagnóstico por imagem , Corpo Vítreo/patologia , Descolamento do Vítreo/diagnóstico por imagem , Descolamento do Vítreo/patologia , Adulto Jovem
18.
JAMA Ophthalmol ; 137(7): 834-837, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31046111

RESUMO

Importance: Bilateral diffuse uveal melanocytic proliferation is a rare sign of several systemic malignant neoplasms. Observations: A patient presenting with uveal melanocytic proliferation underwent a detailed physical examination and extensive imaging. No systemic malignant neoplasm was found. Chorioretinal biopsy was performed, and its immunohistochemical results revealed the presence of primary vitreoretinal lymphoma. Conclusions and Relevance: This patient's results suggest that diffuse uveal melanocytic proliferation may be associated not just with systemic malignant disease, but also with primary intraocular tumors, in this case a primary vitreoretinal lymphoma.


Assuntos
Proliferação de Células , Linfoma Difuso de Grandes Células B/patologia , Melanócitos/patologia , Síndromes Paraneoplásicas Oculares/patologia , Neoplasias da Retina/patologia , Úvea/patologia , Corpo Vítreo/patologia , Antimetabólitos Antineoplásicos/uso terapêutico , Biomarcadores Tumorais/metabolismo , Feminino , Angiofluoresceinografia , Humanos , Infusões Intravenosas , Injeções Intravítreas , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/metabolismo , Metotrexato/uso terapêutico , Pessoa de Meia-Idade , Proteínas de Neoplasias/metabolismo , Síndromes Paraneoplásicas Oculares/tratamento farmacológico , Síndromes Paraneoplásicas Oculares/metabolismo , Neoplasias da Retina/tratamento farmacológico , Neoplasias da Retina/metabolismo , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Corpo Vítreo/efeitos dos fármacos , Corpo Vítreo/metabolismo
19.
Ophthalmic Surg Lasers Imaging Retina ; 50(5): 330-331, 2019 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-31100166

RESUMO

Persistent fetal vasculature (PFV) is a well-defined phenomenon that is characterized by the presence of fetal hyaloid vessels within the eye after birth. Although there have been numerous studies describing the occurrence, surgical management, and possible pathogenesis of PFV, few studies have discussed the possibility of a patient having more than one vascular stalk. The authors describe a 5-year-old female with PFV having two well-delineated stalks. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:330-331.].


Assuntos
Vítreo Primário Hiperplásico Persistente/diagnóstico , Vasos Retinianos/diagnóstico por imagem , Acuidade Visual , Vitrectomia/métodos , Corpo Vítreo/patologia , Pré-Escolar , Feminino , Humanos , Microscopia com Lâmpada de Fenda
20.
Graefes Arch Clin Exp Ophthalmol ; 257(7): 1519-1525, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31062144

RESUMO

PURPOSE: Oxidative stress has been implicated in the pathogenesis of various disorders, including diabetic retinopathy (DR). Oxidative stress-responsive apoptosis-inducing protein (ORAIP; a tyrosine-sulfated secreted form of eukaryotic translation initiation factor 5A [eIF5A]) is a recently discovered pro-apoptotic ligand that is secreted from cells in response to oxidative stress and induces apoptosis in an autocrine fashion. This study aimed to determine if ORAIP plays a role in DR. METHODS: To investigate the role of ORAIP in DR, we analyzed the levels of ORAIP in the vitreous body and their relationship with the extent of proliferative diabetic retinopathy (PDR). Enzyme-linked immunosorbent assay was used to quantify the levels of ORAIP, vascular endothelial growth factor (VEGF), C-C motif chemokine ligand 2 (CCL2), interleukin-6 (IL-6), and IL-8 in the vitreous body of 40 eyes from 28 patients with PDR and 11 patients with non-PDR (NPDR). We also analyzed the expression of ORAIP in insoluble proliferative tissues from vitreous body samples by immunofluorescent staining. RESULTS: The vitreous body concentration of ORAIP was significantly (P = 0.0433) higher in the PDR group (52.26 ± 8.68 [mean ± SE] ng/mL, n = 29) than in the NPDR group (28.21 ± 7.30 ng/mL, n = 11). However, there were no significant correlations between the concentration of ORAIP and those of VEGF, IL-6, CCL2, or IL-8. ORAIP expression was observed in the insoluble proliferative tissues in vitreous body samples of most patients in the PDR group, whereas almost no expression of ORAIP was observed in patients in the NPDR group. CONCLUSIONS: Our findings strongly suggest that ORAIP plays a role in oxidative stress-induced retinal injury and may be a sensitive diagnostic marker and a promising therapeutic target for oxidative stress-induced cytotoxicity.


Assuntos
Proteínas Reguladoras de Apoptose/metabolismo , Retinopatia Diabética/metabolismo , Estresse Oxidativo , Corpo Vítreo/metabolismo , Apoptose , Biomarcadores/metabolismo , Quimiocinas/metabolismo , Retinopatia Diabética/patologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Corpo Vítreo/patologia
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