Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 3.005
Filtrar
1.
J Cancer Res Ther ; 16(4): 935-937, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32930146

RESUMO

Bone metastasis from lung primary is not uncommon and about one-third of bone metastases originate from lung. However, skull bone metastasis is uncommon from lung carcinoma. Metastasis to skull bone and scalp as an initial presentation of lung carcinoma is a very rare phenomenon. We have diagnosed a case of calvarial metastasis with scalp swelling as an initial presentation of adenocarcinoma of lung by fine-needle aspiration cytology in an aged female. Radiologically, it was suggested as tuberculous lesion but cytology gave the correct diagnosis. Here, we present a rare case of calvarial metastasis as a presentation of adenocarcinoma of lung in an elderly female.


Assuntos
Adenocarcinoma de Pulmão/patologia , Neoplasias Pulmonares/patologia , Couro Cabeludo/patologia , Neoplasias Cranianas/secundário , Adenocarcinoma de Pulmão/cirurgia , Idoso , Citodiagnóstico/métodos , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/cirurgia , Prognóstico , Couro Cabeludo/cirurgia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/cirurgia
2.
Dermatol Online J ; 26(5)2020 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-32621703

RESUMO

Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a cotton-like consistency. This condition is palpable rather than visible. It is a casual finding because it is usually asymptomatic, although it may involve alopecia, pruritus, or dysesthesia. We report a 10-year-old girl with lipedematous scalp without alopecia. Sonographic and MRI findings confirmed the diagnosis of lipidematous scalp.  El lipedema de cuero cabelludo o cuero cabelludo lipedematoso es una entidad infrecuente y de etiología desconocida, rara vez descrita en la edad pediátrica. Se caracteriza por un engrosamiento difuso y de tacto esponjoso del tejido celular subcutáneo localizado principalmente en vértex y occipucio. Suele ser un hallazgo casual dado que habitualmente cursa de forma asintomática, aunque puede asociar alopecia, prurito o disestesias. Presentamos el caso de una niña de 10 años de edad con lipedema de cuero cabelludo sin alopecia asociada. Los hallazgos ecográficos y de resonancia magnética confirmaron el diagnóstico de lipedema de cuero cabelludo.


Assuntos
Lipedema/patologia , Dermatoses do Couro Cabeludo/patologia , Criança , Feminino , Humanos , Lipedema/diagnóstico por imagem , Imagem por Ressonância Magnética , Couro Cabeludo/patologia , Dermatoses do Couro Cabeludo/diagnóstico por imagem , Ultrassonografia
3.
Pathologe ; 41(4): 371-378, 2020 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-32500423

RESUMO

Pathologists often feel discomfort when confronted with scalp biopsies, especially in the case of horizontal sectioning, which is particularly useful in the event of nonscarring alopecia. Apart from a profound knowledge of follicular anatomy, one should be capable of correlating the histologic information with the clinical features of various inflammatory scalp disorders. This review addresses the basic principles of the interpretation of scalp biopsies and discusses the most common forms of scarring and nonscarring alopecia.


Assuntos
Alopecia , Couro Cabeludo , Alopecia/diagnóstico , Biópsia , Cicatriz , Humanos , Couro Cabeludo/patologia
4.
Clin Exp Dermatol ; 45(6): 727-731, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32311113

RESUMO

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen planus and either bullous pemphigoid or mucous membrane pemphigoid (MMP) features. Frontal fibrosing alopecia (FFA) is a scarring alopecia, generally considered a form of lichen planopilaris. We report two patients with concomitant FFA and MPP. Patient 1 was a 73-year-old woman with the clinical and histological diagnosis of oral lichen planus. In addition, she presented alopecic plaques in the parietal area with blisters, immunohistologically compatible with Brunsting-Perry pemphigoid, a variant of MMP. During follow-up, the patient also developed FFA. Patient 2 was a 70-year-old woman with a history of ocular inflammation and desquamative gingivitis, who was diagnosed with MMP based on a conjunctival biopsy. She also had clinical features of FFA. ELISA and frontal biopsy confirmed the diagnoses of MMP and FFA. In conclusion, we report two patients with MMP associated with FFA, and discuss whether this association is a new variant of LPP or an incidental finding.


Assuntos
Alopecia/complicações , Líquen Plano/complicações , Doenças da Boca/patologia , Mucosa Bucal/patologia , Penfigoide Mucomembranoso Benigno/complicações , Idoso , Alopecia/patologia , Feminino , Gengivite/complicações , Humanos , Líquen Plano/patologia , Penfigoide Mucomembranoso Benigno/patologia , Couro Cabeludo/patologia
5.
Dermatol Online J ; 26(2)2020 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-32239885

RESUMO

Background Folliculitis decalvans is a neutrophilic cicatricial alopecia whose etiology remains unknown. It is frequently associated with staphylococcal infections. We aimed to determine the rate of gram-negative infections in patients with folliculitis decalvans. Methods A retrospective chart review was performed of patients with biopsy-proven folliculitis decalvans seen at a tertiary hair referral center. The results of bacterial cultures were evaluated. Subjects were determined to have no infection, gram-positive infections, gram-negative infections, or mixed infections. Results Thirty-nine subjects were included in the study. Ninety-three cultures were performed. The majority of cultures were positive for staphylococci. Eleven patients (28%) had gram-negative infections of the scalp. Gram-negative infections comprised one-third of all cultures (33%). Conclusion We present the largest cohort of folliculitis decalvans patients with gram-negative infections, suggesting the need for routine bacterial cultures in patients who are not responsive to standard anti-staphylococcal antibiotics. Awareness of the incidence of these infections may lead to better therapeutic outcomes.


Assuntos
Foliculite/microbiologia , Bactérias Gram-Negativas/isolamento & purificação , Infecções por Bactérias Gram-Negativas/complicações , Dermatoses do Couro Cabeludo/microbiologia , Adulto , Idoso , Biópsia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Couro Cabeludo/microbiologia , Couro Cabeludo/patologia
6.
Dermatol Online J ; 26(2)2020 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-32239901

RESUMO

Aplasia cutis congenita (ACC) is a congenital disorder characterized by localized or generalized absence of skin. Bullous aplasia cutis congenita (BACC) is a rare clinical subtype that has few documented reports in the literature. Herein, we present a new case of BACC in which the bulla was unruptured at birth.


Assuntos
Displasia Ectodérmica/patologia , Dermatoses do Couro Cabeludo/patologia , Couro Cabeludo/patologia , Feminino , Humanos , Recém-Nascido , Doenças Raras
7.
Hautarzt ; 71(6): 435-436, 2020 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-32333040

RESUMO

We present the case of a 31-year-old soldier who developed three independent melanomas in only 2 years. We saw two mucosal melanomas and one nodular melanoma of the scalp. The last one led to a cerebral metastasis during the course of the follow-up. After complete resection and under ongoing immunotherapy with nivolumab, there was no progression of disease until December 2019. The Karnofsky index remained at 100% and there were no side effects of therapy. Besides fair skin type, no other risk factors for the development of melanomas were identified, even after performing genetic analysis.


Assuntos
Neoplasias Encefálicas/patologia , Melanoma/diagnóstico , Couro Cabeludo/patologia , Neoplasias Cutâneas/diagnóstico , Adulto , Antineoplásicos Imunológicos/uso terapêutico , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/secundário , Humanos , Imunoterapia/métodos , Metástase Linfática/patologia , Masculino , Nivolumabe/uso terapêutico , Prognóstico , Biópsia de Linfonodo Sentinela , Neoplasias Cutâneas/tratamento farmacológico , Resultado do Tratamento
8.
Reumatol. clín. (Barc.) ; 16(2,pt.2): 180-182, mar.-abr. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-194345

RESUMO

La psoriasis es una frecuente dermatosis inflamatoria que puede asociarse a diversas enfermedades. Estudios recientes señalan que la presencia de enfermedades autoinmunes es mayor, pero es rara la asociación con enfermedades del tejido conectivo. La coexistencia con lupus es infrecuente. Por otra parte, la morfea raramente se ha reportado en pacientes con lupus o psoriasis. Presentamos a una paciente con lupus cutáneo y morfea profunda que posteriormente desarrolló psoriasis, con excelente respuesta a metotrexato y revisamos la literatura


Psoriasis is a common inflammatory dermatosis that may be associated with a number of diseases. Recent studies provide evidence that there is a greater frequency of autoimmune diseases, but association with autoimmune connective tissue diseases is uncommon. The coexistence of psoriasis and lupus erythematosus is rare. Besides, the occurrence of morphea has rarely been reported in patients with lupus or psoriasis. We report a woman with cutaneous lupus and morphea profunda associated with psoriasis, with an excellent response to methotrexate, and review the literature


Assuntos
Humanos , Feminino , Idoso , Lúpus Eritematoso Cutâneo/diagnóstico , Lúpus Eritematoso Cutâneo/patologia , Esclerodermia Localizada/patologia , Psoríase/patologia , Couro Cabeludo/patologia , Lúpus Eritematoso Cutâneo/tratamento farmacológico , Esclerodermia Localizada/tratamento farmacológico , Psoríase/tratamento farmacológico , Autoimunidade , Prednisona/administração & dosagem , Corticosteroides/administração & dosagem , Administração Tópica , Couro Cabeludo/efeitos dos fármacos , Biópsia , Psoríase/etiologia
10.
World Neurosurg ; 138: 182-186, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32145423

RESUMO

BACKGROUND: Meningioma, a neoplasm of the meninges, is usually a benign localized tumor. Extraneural metastasis is an extremely rare complication of meningiomas, and only a few cases have been reported to date. The present study reports a case of scalp metastasis of an atypical meningioma and discusses the types of atypical meningiomas and their management options. CASE DESCRIPTION: A 69-year-old man presented with scalp metastasis of an atypical meningioma. Six years after the right frontoparietal meningioma lesion was completely resected, an isolated subcutaneous metastasis developed at the right frontal region of the scalp, originating at the scar left by the first surgery. Postoperative histologic examination of the subcutaneous tumor revealed the features of an atypical meningioma. CONCLUSIONS: This study highlights that resection of meningiomas is still associated with a risk of iatrogenic metastasis. Surgeons should carefully wash out the operative field and change surgical tools frequently to avoid the potential risk of metastasis.


Assuntos
Neoplasias Meníngeas/patologia , Meningioma/secundário , Inoculação de Neoplasia , Couro Cabeludo/patologia , Neoplasias Cutâneas/secundário , Idoso , Humanos , Masculino , Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Tela Subcutânea/patologia
12.
Anticancer Res ; 40(3): 1645-1649, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32132069

RESUMO

In inoperable patients, the management of angiosarcoma of the scalp is challenging. Due to intrinsic, dosimetric and radiobiological properties, proton beam radiotherapy may be an effective and safe option to offer to these difficult-to-cure patients. Here, we report a case of angiosarcoma of the scalp treated successfully with proton beam radiotherapy. Angiosarcoma is a rare malignancy concerning around 2% of soft-tissue sarcomas and 5% of cutaneous soft-tissue sarcomas. Cutaneous angiosarcomas can occur in any part of the body, but the head and neck region is a common primary site and the scalp is a frequent site in elderly patients.


Assuntos
Neoplasias de Cabeça e Pescoço/radioterapia , Hemangiossarcoma/radioterapia , Terapia com Prótons/métodos , Couro Cabeludo/patologia , Idoso de 80 Anos ou mais , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/patologia , Hemangiossarcoma/mortalidade , Hemangiossarcoma/patologia , Humanos , Masculino , Taxa de Sobrevida
15.
World Neurosurg ; 137: 261-265, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32035211

RESUMO

BACKGROUND: The most common sites of breast cancer metastases are the bone, lung, liver, and brain. Scalp involvement in breast cancer metastasis is extraordinarily rare. CASE DESCRIPTION: This study reports a 52-year-old woman who had a history of malignant right breast cancer and underwent a mastectomy. Positron emission tomography/computed tomography revealed a soft tissue nodule measuring 1 × 0.7 cm located subcutaneously on the top left side of the scalp. A scalp mass excision operation was performed with an extended "S"-shaped incision, and the mass was sent for pathology. Immunohistochemistry showed the following results: CK7: +; ER: 2+, 90%; GATA3: +; GCDFP-15: scattered cells+; mammaglobin: -, napsin A: -; and TTF-1: -. These results were consistent with the characteristics of primary right breast cancer, supporting scalp metastasis from breast cancer. CONCLUSIONS: Scalp metastasis from breast cancer is an exceedingly infrequent phenomenon. Close attention should be paid to soft tissue masses in patients with a healthy appearance and in those with a history of malignant cancer. When neurosurgeons operate on the mass, the circumscription and depth of the tumor must be given further attention.


Assuntos
Adenocarcinoma/secundário , Adenocarcinoma/cirurgia , Neoplasias da Mama/patologia , Procedimentos Neurocirúrgicos/métodos , Couro Cabeludo/cirurgia , Neoplasias Cutâneas/secundário , Neoplasias Cutâneas/cirurgia , Adenocarcinoma/diagnóstico por imagem , Feminino , Humanos , Imuno-Histoquímica , Mastectomia , Pessoa de Meia-Idade , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Couro Cabeludo/diagnóstico por imagem , Couro Cabeludo/patologia , Neoplasias Cutâneas/diagnóstico por imagem , Resultado do Tratamento
17.
J Dermatolog Treat ; 31(3): 285-289, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30836026

RESUMO

Background: Actinic keratoses (AK) represent common cutaneous lesions, appearing in 'Field cancerization areas' and potentially evolving toward invasive neoplasm. Immunosuppressed patients frequently develop numerous and aggressive AKs.Aim: In this observational study, we report our experience with topical Imiquimod 3.75% as 'Field-directed therapy' in a cohort of immunosuppressed patients.Methods: A group of 13 immunosuppressed patients presenting multiple AKs of the balding scalp was treated with topical Imiquimod 3.75%. Each patient underwent clinical examination at fixed timepoints during the treatment (T0, T14, T28, T42) and eight weeks after the end.Results: In our cohort, the treatment was well tolerated, with minimal local adverse events. We observed a good clinical response, in terms of Lmax lesions (maximum lesion count during the course of therapy) and of AK clearance. In our group, 46% of patients showed no detectable lesions at the end of the observation period, and this result was maintained up to 1 year after the end of treatment.Conclusion: Topical Imiquimod 3.75% represents an effective and safe treatment for multiple AK of the scalp also in immunosuppressed patients. To the best of our knowledge, this is the first report on the use of this drug in this category of subjects.


Assuntos
Antineoplásicos/uso terapêutico , Imiquimode/uso terapêutico , Ceratose Actínica/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/efeitos adversos , Eritema/etiologia , Feminino , Humanos , Imiquimode/efeitos adversos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Couro Cabeludo/patologia , Resultado do Tratamento
18.
Int J Pediatr Otorhinolaryngol ; 130: 109853, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31887567

RESUMO

OBJECTIVES: Minimizing soft tissue reduction during the placement of percutaneous implants has been encouraged to improve cosmesis and perhaps decrease soft tissue complications. However, the fidelity of sound transmission and retention of transcutaneous magnet devices relates to the intervening soft tissue thickness. The objective of this study was to examine age-related variability in scalp thickness in patients receiving either percutaneously implanted or transcutaneous magnet-retained auditory prostheses. METHODS: Children undergoing percutaneous implant retained prostheses or cochlear implantation underwent two scalp thickness measurements: 1) a superior measurement at the conventional marked site for cochlear implant receiver stimulator and 2) an inferior measurement 1.5 cm below the superior measurement representing the conventional marked site for cochlear implant fantail. Linear regression was used for statistical analysis. RESULTS: Eighty-five children (median age 6 years; range 9 months-17 years) were examined. Scalp thickness at the two sites ranged from 1 to 10 mm (superior mean = 4.1 mm; inferior mean = 4.3 mm). A strong correlation was observed between age and scalp thickness at the superior (R = 0.62, p < 0.01) measurement, while a moderate correlation was observed at the inferior (R = 0.45, p < 0.01) sites. Children younger than 7 years displayed little variability in scalp thickness, and no correlation between age and scalp thickness (R = 0.002, p = 0.74). CONCLUSION: In older children, scalp thickness varies significantly with age. However, children younger than 7 years consistently have scalp thicknesses of 3-4 mm. Lack of variability in scalp thickness in children younger than 7 years argues against the use of an age-adjusted approach to soft tissue management in this age group.


Assuntos
Implante Coclear , Implantes Cocleares , Seleção de Pacientes , Couro Cabeludo/patologia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA