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1.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(10): 850-854, dic. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-185607

RESUMO

El tumor pilar proliferante es una neoplasia cutánea rara, que se deriva de la vaina de la raíz externa de los folículos pilosos con un amplio espectro en su presentación dado a que puede variar desde la benignidad hasta la malignidad con alta probabilidad de recurrencia posterior a su escisión. En este artículo describimos la experiencia del Hospital de San José en Bogotá, Colombia en el manejo de 3 tumores pilares proliferantes, con una presentación clínica y un comportamiento patológico distinto


A proliferating pilar tumor is a rare skin neoplasm that arises from the outer root sheath of a hair follicle. Presentation varies widely, as the tumor can be benign or malignant and has a high probability of recurring after excision. We report our experience managing 3 proliferating pilar tumors with different clinical presentations and pathology findings at Hospital de San José, Bogota, Colombia


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias Cutâneas/diagnóstico , Diagnóstico Diferencial , Couro Cabeludo/patologia , Cisto Epidérmico/patologia , Folículo Piloso/patologia , Imuno-Histoquímica , Queratinócitos/patologia , Neoplasias Cutâneas/patologia
3.
An Bras Dermatol ; 94(5): 590-593, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777362

RESUMO

The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology.


Assuntos
Carcinoma/patologia , Couro Cabeludo/patologia , Neoplasias das Glândulas Sebáceas/patologia , Neoplasias Cutâneas/patologia , Idoso de 80 Anos ou mais , Biópsia , Carcinoma/diagnóstico , Dermoscopia , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Neoplasias das Glândulas Sebáceas/diagnóstico , Neoplasias Cutâneas/diagnóstico
7.
J Surg Oncol ; 120(8): 1470-1475, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31614003

RESUMO

BACKGROUND: Patients with scalp melanoma have poor oncologic outcomes compared with those with other cutaneous sites. Sentinel lymph node (SLN) biopsy provides prognostic information but is challenging in the head and neck. We explore the anatomic distribution of scalp melanoma and describe the most common sites of SLN drainage and of SLN metastatic disease. METHODS: Retrospective review of scalp melanoma patients who underwent SLN biopsy. Melanoma location was classified as frontal, coronal apex, coronal temporal, or posterior scalp. SLN location was classified by lymph node level and region. RESULTS: We identified 128 patients with scalp melanoma. The most common primary tumor location was the posterior scalp (43%) and the most frequent SLN drainage site was the level 2 lymph node basin (48%). Total 31 patients (24%) had metastatic disease in an SLN. Scalp SLNs, classified as being in the posterior auricular or occipital region, were localized in 26% of patients. For patients in which a scalp SLN was identified, 30% had a positive scalp SLN (n = 10). CONCLUSIONS: Scalp SLNs are frequent drainage sites for scalp melanoma and, when found, have a 30% chance of harboring metastatic disease. Surgeons, radiologists, and pathologists should be vigilant in identifying, removing, and analyzing scalp SLNs.


Assuntos
Metástase Linfática , Melanoma/patologia , Couro Cabeludo/patologia , Biópsia de Linfonodo Sentinela , Linfonodo Sentinela/patologia , Neoplasias Cutâneas/patologia , Idoso , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Melanoma/mortalidade , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Estudos Retrospectivos , Neoplasias Cutâneas/mortalidade
8.
An Bras Dermatol ; 94(4): 416-421, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644613

RESUMO

BACKGROUND: Frontal fibrosing alopecia is a condition of unknown origin, histologically similar to classic lichen planopilaris and generally observed in postmenopausal women with alopecia of the frontal-temporal hairline. OBJECTIVES: To describe the clinical, dermatoscopic, and histopathological characteristics and the treatment used in patients who have frontal fibrosing alopecia at the Alopecia Outpatient Clinic in a university hospital. METHODS: Retrospective descriptive study performed by reviewing medical charts and biopsies of the scalp. RESULTS: Sixteen patients were analyzed, all of them female, 93.75% of them postmenopausal, and 56.25% brown-skinned. All had frontal alopecia (100%), followed by temporal alopecia (87.5%) and madarosis (87.5%). On dermatoscopy, perifollicular erythema and tubular scales were found as a sign of disease activity. Of the patients, 68.75% had associated autoimmune diseases, including lupus, thyroid disease and vitiligo. Of the 13 biopsies from 8 patients, 10 showed microscopic aspects compatible with frontal fibrosing alopecia. Laboratory tests did not show major abnormalities and minoxidil was the most used treatment. STUDY LIMITATION: Data collection limited by the study's retrospective design associated to flaws while filling in the medical charts and absence in standards to the collection and processing of the pathology and histopathological examination. CONCLUSIONS: A demographical, clinical, and histopathological description of 16 patients diagnosed with frontal fibrosing alopecia, which remains a challenging disease, of unknown origin, and frequently associated with autoimmune diseases. This study reinforces literary findings. However, more research is needed to establish the pathogenesis and effective treatments.


Assuntos
Alopecia/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Alopecia/tratamento farmacológico , Biópsia , Dermoscopia/métodos , Feminino , Fibrose , Folículo Piloso/patologia , Hospitais Universitários , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Couro Cabeludo/patologia
9.
An Bras Dermatol ; 94(4): 452-454, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644620

RESUMO

Proliferating trichilemmal cyst is an uncommon neoplasm arising from the follicular isthmus, whose histopathological hallmark is the presence of trichilemmal keratinization. We describe a case of proliferating trichilemmal cyst in a 57-year-old woman with a broad clinical, radiological, macroscopic and microscopic correlation.


Assuntos
Cisto Epidérmico/diagnóstico por imagem , Cisto Epidérmico/patologia , Couro Cabeludo/diagnóstico por imagem , Couro Cabeludo/patologia , Biópsia por Agulha Fina , Diagnóstico Diferencial , Cisto Epidérmico/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Couro Cabeludo/cirurgia , Ultrassonografia
10.
Ned Tijdschr Geneeskd ; 1632019 10 02.
Artigo em Holandês | MEDLINE | ID: mdl-31580030

RESUMO

A 52-year-old woman was referred to a dermatologist with a changed yellowish lesion on her scalp. Histological features were those of a sebaceous naevus with secondary malignant differentiation into superficial and solid basal cell carcinoma. A sebaceous naevus is a benign, congenital, hamartomatous lesion. In adulthood, secondary neoplasms may develop within them.


Assuntos
Carcinoma Basocelular/patologia , Neoplasias de Cabeça e Pescoço/patologia , Nevo/patologia , Neoplasias das Glândulas Sebáceas/patologia , Neoplasias Cutâneas/patologia , Feminino , Hamartoma/patologia , Humanos , Pessoa de Meia-Idade , Couro Cabeludo/patologia
12.
Rev. Hosp. Ital. B. Aires (2004) ; 39(3): 98-100, sept. 2019. ilus.
Artigo em Espanhol | LILACS | ID: biblio-1048365

RESUMO

El adenocarcinoma mucinoso primario de piel es una neoplasia anexial, maligna e infrecuente, que afecta principalmente a hombres en una relación 2:1 con respecto a las mujeres. Presenta mayor incidencia entre la sexta y séptima década de la vida, y se manifiesta como un tumor único, asintomático, de tamaño variable. La localización más frecuente es la región periorbitaria y el cuero cabelludo. Se comunica el caso de una paciente de 92 años, con diagnóstico de carcinoma mucinoso primario de piel, sin evidencia de enfermedad sistémica ni recurrencia local al año de la resección por cirugía micrográfica de Mohs. Describimos sus principales características clínicas, dermatoscópicas y hallazgos histopatológicos. (AU)


Primary mucinous adenocarcinoma of the skin is an adnexal, malignant, and infrequent neoplasm that mainly affects men with a 2: 1 ratio, with respect to women. It presents higher incidence between the sixth and seventh decade of life, and manifests as a single tumor, asymptomatic, of variable size. The most frequent location is the periorbital region and scalp. We report the case of a 92-year-old patient with a diagnosis of primary mucinous skin carcinoma, without evidence of systemic disease or local recurrence one year after resection by Mohs micrographic surgery. We describe its main clinical features, dermatoscopic and histopathological findings. (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Cutâneas/diagnóstico por imagem , Adenocarcinoma Mucinoso/diagnóstico por imagem , Metástase Neoplásica/diagnóstico por imagem , Couro Cabeludo/patologia , Carcinoma de Células Escamosas/cirurgia , Adenocarcinoma Mucinoso/cirurgia , Adenocarcinoma Mucinoso/etiologia , Adenocarcinoma Mucinoso/ultraestrutura , Adenocarcinoma Mucinoso/epidemiologia , Glândulas Écrinas/ultraestrutura
15.
Am J Case Rep ; 20: 1141-1143, 2019 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-31375657

RESUMO

BACKGROUND Epidermoid cysts are the most common benign skin lesions that can occur anywhere on the body, and frequently occur on the face, scalp, neck, and trunk. Typically, patients are asymptomatic, and the lesions present as firm skin-colored nodules filled with keratinous or sebaceous materials that are formed by cystic expansion of the epidermal epithelium. Malignant transformation is rare in epidermoid cysts. CASE REPORT This is a case report of a 77-year-old male Caucasian patient who presented with an epidermoid cyst on the left parietal area. Due to high suspicion, the cyst was surgically excised and sent to pathology which resulted in discovery of malignant squamous cell carcinoma with unclear margins. Aimed at obtaining clear margins, a wide excision was performed, which revealed clean margins and absence of residual cancerous cells. The patient recovered well without major complications. CONCLUSIONS Although the prevalence of epidermoid cysts is high, malignant transformation of epidermoid cysts into squamous cell carcinoma is rare. Due to its scarcity, the exact pathophysiology of malignant transformation is still poorly understood. The differential diagnosis should include the possibility of malignancy for highly suspicious lesions, and proper management guidelines should be established. Surgical resection should be the treatment of choice, and once removed, all surgically excised cysts should undergo pathologic evaluation. As clinicians, it is crucial to stay vigilant and have a low threshold for excision and thorough histological examination of specimens to allow early diagnosis and interventions which can significantly improve patient outcomes. Through the suggested guidelines, we hope to aid in better management and intervention in case of malignant transformation of epidermoid cysts.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Transformação Celular Neoplásica , Cisto Epidérmico/diagnóstico , Couro Cabeludo/patologia , Neoplasias Cutâneas/diagnóstico , Idoso , Carcinoma de Células Escamosas/cirurgia , Diagnóstico Diferencial , Cisto Epidérmico/cirurgia , Humanos , Masculino , Margens de Excisão , Couro Cabeludo/cirurgia , Neoplasias Cutâneas/cirurgia
19.
Biomed Res Int ; 2019: 5128376, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31360714

RESUMO

Background: Scalp seborrheic dermatitis (SD) is a common and chronic inflammatory skin disease which tends to recur over time. By measuring biophysical properties of the stratum corneum, many studies report abnormal biophysical profiles and their association in various dermatologic diseases. The aim of the study is to analyze the biophysical properties and skin barrier defects of scalp SD compared to healthy controls. Materials and Methods: This study is a cross-sectional study assessing the correlation of various biophysical and physiological profiles in scalp SD. Forty-two Thai participants with scalp SD were enrolled in the study and 40 healthy participants were also enrolled as the control group. Both SD and control group were subjected to a one-time biophysical and physiological properties' measurement of transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin surface pH, skin surface lipid, and skin roughness. Results: The mean TEWL of lesional skin of SD cases were significantly higher than those of control group (P<0.05). Relating to high mean TEWL, the mean SCH was found to be significantly lower in SD cases (P<0.05). Skin surface lipid was also found to be significantly higher in SD group (P<0.05). However, there were no differences in skin surface pH (P=0.104) and roughness (P=0.308) between the two groups. Pairwise comparison of each subgroup found that moderate and severe SD demonstrated significantly higher mean skin surface lipid than that of control group (P<0.05). Conclusion: Scalp SD may be associated with seborrhea in Thai population. Monitoring of SCH, TEWL, and skin surface lipid could be helpful in assessing severity and evaluating the treatment outcome in patients with scalp SD.


Assuntos
Dermatite Seborreica , Epiderme , Couro Cabeludo , Perda Insensível de Água , Adulto , Estudos Transversais , Dermatite Seborreica/epidemiologia , Dermatite Seborreica/patologia , Dermatite Seborreica/fisiopatologia , Epiderme/patologia , Epiderme/fisiopatologia , Feminino , Humanos , Masculino , Couro Cabeludo/patologia , Couro Cabeludo/fisiopatologia , Tailândia/epidemiologia
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