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1.
Braz. j. biol ; 83: e242703, 2023. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1285636

RESUMO

Abstract Oral diseases caused by various microorganisms are common around the world. Scientific research has now been focusing on novel medicines to overcome bacterial resistance and antibiotics side effects; therefore, the current study was designed to assess the efficacy of certain antibiotics, toothpaste, and medicinal plant extracts (Ajuga bracteosa and Curcuma longa) versus the bacterial pathogens isolated from the human oral cavity. A total of 130 samples were collected from Khyber Teaching Hospital Peshawar, Pakistan, among those 27 species isolated, and eight bacterial species were identified from the samples. Among all the bacterial species, Staphylococcus aureus (29.62%) and Proteus mirabilis (22.2%) were found to be more prevalent oral pathogens. In comparison, the least pervasive microbes were Proteus vulgaris, Shigella sonnei, Escherichia coli and Aeromonas hydrophila. The study also suggested that dental problems were more prevalent in males (41-50 years of age) than females. Among the eight antibiotics used in the study, the most promising results were shown by Foxicillin against A. hydrophila. The survey of TP1 revealed that it showed more potent antagonist activity against Proteus vulgaris as compared TP2 and TP3 that might be due to the high content of fluoride. The Curcuma longa showed more significant activity than Ajuga bracteosa (Stem, leaves and root) extracts. The data obtained through this study revealed that antibiotics were more effective for oral bacterial pathogens than toothpaste and plant extracts which showed moderate and low activity, respectively. Therefore, it is suggested that the active compounds in individual medicinal plants like Curcuma longa and Ajuga bracteosa could replace the antibiotics when used in daily routine as tooth cleansers or mouth rinses.


Resumo As doenças bucais causadas por vários microrganismos são comuns em todo o mundo. A pesquisa científica agora tem se concentrado em novos medicamentos para superar a resistência bacteriana e os efeitos colaterais dos antibióticos; portanto, o presente estudo foi desenhado para avaliar a eficácia de certos antibióticos, pasta de dente e extratos de plantas medicinais (Ajuga bracteosa e Curcuma longa) contra os patógenos bacterianos isolados da cavidade oral humana. No total, 130 amostras foram coletadas do Khyber Teaching Hospital Peshawar, Paquistão, entre essas, 27 espécies foram isoladas e oito espécies bacterianas foram identificadas a partir das amostras. Entre todas as espécies bacterianas, Staphylococcus aureus (29.62%) e Proteus mirabilis (22.2%) foram os patógenos orais mais prevalentes. Em comparação, os micróbios menos difundidos foram Proteus vulgaris, Shigella sonnei, Escherichia coli e Aeromonas hydrophila. O estudo também sugeriu que os problemas dentários eram mais prevalentes em homens (41-50 anos de idade) do que em mulheres. Entre os oito antibióticos usados ​​no estudo, os resultados mais promissores foram mostrados pelo Foxicillin contra A. hydrophila. A pesquisa de TP1 revelou que ele mostrou atividade antagonista mais potente contra Proteus vulgaris em comparação a TP2 e TP3, o que pode ser devido ao alto teor de flúor. A Curcuma longa apresentou atividade mais significativa em relação aos extratos de Ajuga bracteosa (caule, folhas e raiz). Os dados obtidos neste estudo revelaram que os antibióticos foram mais eficazes para os patógenos bacterianos orais do que os dentifrícios e os extratos vegetais que apresentaram atividade moderada e baixa, respectivamente. Portanto, sugere-se que os compostos ativos em plantas medicinais individuais como Curcuma longa e Ajuga bracteosa possam substituir os antibióticos quando usados ​​na rotina diária como limpadores de dentes ou enxaguatórios bucais.


Assuntos
Humanos , Masculino , Feminino , Cremes Dentais , Fluoretos , Paquistão , Extratos Vegetais/farmacologia , Testes de Sensibilidade Microbiana , Antibacterianos
2.
Braz. j. oral sci ; 21: e222812, jan.-dez. 2022. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1348712

RESUMO

Aim: To evaluate the influence of the parameters L* a* b* on the variation of the color of bovine tooth enamel submitted to artificial darkening, after simulated brushing, with whitening toothpastes containing blue covarine. Methods: To undertake this study in vitro, 60 specimens (SP) were divided into 6 groups (n=10): control group (CGwater) and 5 test groups (GT1-Colgate Total 12, GT2-Oral-B 3D White Perfection, GT3- Colgate Luminous Instant White, GT4-CloseUp White Diamond Attraction, GT5-Sorriso Xtreme White). The specimens were darkened with coffee and submitted to simulated brushing for 6, 12, and 24 months. The alteration in the color was evaluated using CIELAB parameters and the ΔL, Δa, Δb and ΔE were calculated. The data was analyzed through generalized linear models using the R program and considering a level of significance of 5%. Results: The parameters L*, a* and the ΔL, Δa obtained better results in the test group than in the control group. There were no statistical differences between CG and the test groups for the evaluation of the b* parameter. In the evaluation of the Δb, the GT3 differed statistically from the CG. In relation to the ΔE, all the group tests showed a variation in color statistically greater than that of the CG and the GT4 showed the greatest variation, not differing from the GT3 during the periods studied. Conclusion: The mechanical and optical whitening agents positively influenced the values L*a* and b*, as well as in its variations and in the ΔE. It is important to emphasize, however, that to analyze tooth whitening it is necessary to evaluate their parameters together


Assuntos
Dente , Cremes Dentais , Cor , Clareadores
3.
Int Dent J ; 72(6): 792-796, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36375894

RESUMO

AIM: The objective of this research was to determine the abrasive and remineralising efficacy of quail eggshell (Coturnix coturnix) incorporated into a new experimental toothpaste. METHODS: An experimental study was designed to compare the surface microhardness of the dental enamel of bovine lateral incisors exposed to different toothpastes. In relation to microroughness (abrasive efficiency), the unit of analysis was each specimen with 16 polymethylmethacrylate (PMMA) blocks. For the remineralisation variable, the unit of analysis was each bovine lateral incisor tooth. A sample size of 16 was determined for each group. RESULTS: The unpolished PMMA specimens presented the highest mean surface microroughness with a mean of 4.60 ± 1.47 µm, whilst the quail paste, universal polishing paste, control paste, and Diamond Excel Paste showed a mean of 1.16 ± 0.40 µm, 0.63 ± 024 µm, 0.45 ± 0.22 µm, and 0.43 ± 0.17 µm, respectively, presenting significant differences (P < .001). When comparing the surface microhardness of bovine lateral incisor dental enamel exposed to different toothpastes, the universal polishing paste presented the lowest microhardness, with 192.43 ± 56.21 kg/mm2, whilst the quail paste presented the greatest remineralising effect, with the highest average of 272 ± 21.18 kg/mm2, followed by the control paste with 244 ± 41.43 kg/mm2 and the Diamond Excel Paste with 228.72 ± 43.72 kg/mm2. These differences were statistically significant (P < .001). CONCLUSIONS: Significant differences were found in the surface abrasive efficiency (microroughness) of PMMA subjected to different toothpastes. The quail toothpaste presented statistically significant results compared to the control pastes, the Diamond Excel Paste, and the universal polishing paste.


Assuntos
Coturnix , Cremes Dentais , Bovinos , Animais , Humanos , Cremes Dentais/uso terapêutico , Esmalte Dentário , Casca de Ovo , Polimetil Metacrilato , Diamante
4.
BMC Oral Health ; 22(1): 483, 2022 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-36368979

RESUMO

BACKGROUND: Dentin hypersensitivity is a painful response to external stimuli applied to exposed dentinal tubules. Various toothpastes with active desensitizing ingredients for the relief of dentin hypersensitivity are commercially available. However, data from several studies suggest that the effects of desensitizing toothpastes are unstable and brief. This study aimed to investigate the effect of toothpastes containing CPNE7-derived oligopeptide (CPNE7-DP) and other active desensitizing ingredients in the dentin microleakage, tubule occlusion and tertiary dentin formation. METHODS: Using scanning electron microscopy (SEM), we evaluated the patency of dentinal tubules on the surface of human dentin disks after brushing experiments with the various toothpastes. Dentin was histologically evaluated in a hypersensitivity model of canine teeth, after the exposed dentin area was brushed for 6 weeks. The toothpaste used in group 1 (control) did not contain any desensitizing ingredients; that used in group 2 contained CPNE7-DP; Colgate Sensitive was used in group 3; and Sensodyne Rapid Relief was used in group 4. Finally, we conducted microleakage analysis to investigate the dentin sealing effect. The microleakage analysis data were subjected to one-way ANOVA and post-hoc Tukey tests (alpha = 0.05). RESULTS: In the SEM images, all four groups of teeth exhibited partial occlusion of the dentinal tubules on the tooth surface. In the in vivo hypersensitivity model, group 2 exhibited a newly formed tertiary dentin, whereas no new hard tissue formation was observed in groups 1, 3, and 4. Microleakage analysis revealed that the volume of dentinal fluid flow was significantly smaller in group 2 than in group 1. CONCLUSIONS: These results indicate that CPNE7-DP is a promising active ingredient with long-term dentin sealing effects.


Assuntos
Sensibilidade da Dentina , Cremes Dentais , Humanos , Cremes Dentais/farmacologia , Cremes Dentais/uso terapêutico , Sensibilidade da Dentina/tratamento farmacológico , Dentina , Escovação Dentária/métodos , Fluoreto de Sódio , Microscopia Eletrônica de Varredura
5.
BMC Oral Health ; 22(1): 489, 2022 11 14.
Artigo em Inglês | MEDLINE | ID: mdl-36376830

RESUMO

BACKGROUND: To evaluate the efficacy of fluoride-containing toothpastes with different technologies to remineralize artificial caries lesions in enamel. METHODS: Bovine enamel blocks were divided into three thirds: intact (untreated), demineralized (artificial caries lesion), and treated (caries lesion, pH cycling with dentifrices). Enamel blocks were randomly distributed into five groups (n = 12): Fluoride-free toothpaste, Colgate Oral Care (NC); Arginine-containing toothpaste, Colgate Total Daily Repair (PC); Silicate-based fluoride toothpaste: REFIX technology, regenerador + sensitive (RDC), NR-5 technology, Regenerate Enamel Science (RES), and NOVAMIN technology, Sensodyne Repair and Protect (SRP). The specimens were submitted to a pH cycling model for 6 days. The efficacy of the toothpastes was estimated by calculating the surface microhardness recovery (%SMHR) and the fluorescence recovery (ΔFRE) with quantitative light-induced fluorescence. The cross-sectional micromorphology of the enamel surface was also assessed using scanning electron microscopy. Elemental analyses (weight%) were determined with an energy-dispersive X-ray spectrometer (EDS). The results were compared to that of the control (NC). Data were statistically analyzed (5%). RESULTS: %SMHR could be ranked as follows: RDC = PC = RES = SRP > NC. Significantly higher %SMHR and ΔFRE means were observed after enamel treatment with RDC (22.7 and 46.9, respectively). PC (%SMHR = 18.8) was as efficacious as RDC to recover the surface microhardness with a significantly lower mean of ΔFRE (19.5). Only RDC was able to promote the formation of a mineralized layer on the surface of enamel enriched with silicon on the surface. CONCLUSIONS: The silicate-based fluoride toothpaste containing REFIX technology demonstrated greater efficacy in the remineralizing artificial caries than the other products.


Assuntos
Cárie Dentária , Cremes Dentais , Animais , Bovinos , Humanos , Cariostáticos/uso terapêutico , Estudos Transversais , Cárie Dentária/prevenção & controle , Cárie Dentária/patologia , Esmalte Dentário/patologia , Fluoretos/uso terapêutico , Dureza , Concentração de Íons de Hidrogênio , Fluoreto de Sódio , Tecnologia , Remineralização Dentária/métodos , Cremes Dentais/uso terapêutico
6.
Dental Press J Orthod ; 27(5): e2220325, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36350943

RESUMO

INTRODUCTION: Many patients wearing orthodontic appliances request alterations in the shade of their teeth during orthodontic treatment. OBJECTIVE: This study aimed to evaluate the efficacy of different products for bleaching and whitening under orthodontic brackets. METHODS: Seventy bovine incisors were randomly divided into five groups (n = 14): C) non-whitening toothpaste (control); WTsi) hydrated silica whitening toothpaste; WThp) 2% hydrogen peroxide whitening toothpaste; OB) in-office bleaching; and HB) at-home bleaching. Two buccal surface areas were evaluated using the Easyshade spectrophotometer: under the metal bracket (experimental) and around the bracket (control). The paired t-test, ANOVA, and Tukey tests were applied for statistical analysis. RESULTS: Intragroup comparisons showed that in groups C, WThp and HB, there were statistically significant differences in the enamel color changes (ΔEab) between under and around the bracket areas (C - under bracket = 7.97 ± 2.35, around bracket = 2.86 ± 0.81, p< 0.01; WThp - under bracket = 4.69 ± 2.98, around bracket = 2.05 ± 1.41, p< 0.01; HB - under bracket = 7.41 ± 2.89, around bracket: 9.86 ± 3.32, p= 0.02). Groups WTsi, OB and HB presented similar perception of tooth whiteness (ΔWID) between the tested areas. Intergroup comparisons demonstrated that under the bracket area, the color change (ΔEab) was similar for all groups, except WThp (C = 7.97 ± 2.35; WTsi = 8.54 ± 3.63; WThp = 4.69 ± 2.98; OB = 9.31 ± 4.32; HB = 7.41 ± 2.89; p< 0.01). CONCLUSIONS: The dental color changes were effective for the products tested in groups WTsi, OB and HB in the presence of metallic orthodontic brackets.


Assuntos
Braquetes Ortodônticos , Clareadores Dentários , Clareamento Dental , Animais , Bovinos , Humanos , Cor , Esmalte Dentário , Peróxido de Hidrogênio , Clareadores Dentários/uso terapêutico , Cremes Dentais
7.
Oral Health Prev Dent ; 20(1): 465-474, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36416604

RESUMO

PURPOSE: To determine the salivary flow rate and subsequent dilution of toothpaste and assess the pH of oral fluids during toothbrushing with toothpastes of various pHs. MATERIALS AND METHODS: The study was conducted as an in-vivo trial involving 30 healthy volunteers. The participants took part in a series of trials distributed over four appointments. After a screening check, in which the participants' stimulated and unstimulated salivary flow rate and buffering capacities were determined, four test series involving toothbrushing were conducted. Participants brushed their teeth using a manual toothbrush for 2 min: once without toothpaste and three times using toothpastes of varying pHs. The salivary flow rate and subsequent dilution of the toothpaste was determined. Additionally, the pH of the collected oral fluid was analysed. RESULTS: Brushing teeth with toothpaste caused a statistically significant increase in salivary flow rate (median/IQR in ml/min) (Elmex Kariesschutz 3.29/1.36, Colgate Total Original 3.23/1.08, Elmex Sensitive Professional 3.18/1.39) when compared to brushing teeth using a manual toothbrush without toothpaste (1.85/0.78) (p < 0.05). The variation in pH of the oral fluid samples was dictated primarily by the pH of the toothpaste used. CONCLUSION: The salivary flow rate when brushing using toothpaste was similar across all tested toothpastes, independent of pH, and had an average median of 3.23 ml/min. The dilution of 1 g of toothpaste during a standard toothbrushing procedure of 2 min is therefore approximately at a ratio of one part toothpaste to 6.5 parts saliva.


Assuntos
Escovação Dentária , Cremes Dentais , Humanos , Cremes Dentais/uso terapêutico , Fluoretos , Diaminas
8.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 40(6): 668-675, 2022 Dec 01.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-36416319

RESUMO

OBJECTIVES: The purpose of the study was to evaluate the effect of hydroxyapatite (HA)-based desensiti-zing agents and determine their influence on the bonding performance of mild universal adhesives. METHODS: Mid-coronal dentin samples were sectioned from human third molars and prepared for a dentin-sensitive model. According to desensitizing applications, they were randomly divided into four groups for the following treatments: no desensitizing treatment (control), Biorepair toothpaste (HA-based desensitizing toothpaste) treatment, Dontodent toothpaste (HA-based desensitizing toothpaste) treatment, and HA paste treatment. Dentin tubular occlusion and occluded area ratios were evaluated by scanning electron microscopy (SEM). Furthermore, All-Bond Universal, Single Bond Universal, and Clearfil Universal Bond were applied to the desensitized dentin in self-etch mode. The wettability and surface free energy (SFE) of desensitized dentin were evaluated by contact angle measurements. Bonded specimens were sectioned into beams and tested for micro-tensile bond strength to analyze the effect of desensitizing treatment on the bond strength to dentin of universal adhesives. RESULTS: SEM revealed that the dentin tubule was occluded by HA-based desensitizing agents, and the area ratios for the occluded dentin tubules were in the following order: HA group>Biorepair group>Dontodent group (P<0.05). Contact angle analysis demonstrated that HA-based desensitizing agents had no statistically significant influence on the wettability of the universal adhesives (P>0.05). The SFE of dentin significantly increased after treatment by HA-based desensitizing agents (P<0.05). The micro-tensile bond strength test showed that HA-based desensitizing toothpastes always decreased the µTBS values (P<0.05), whereas the HA paste group presented similar bond strength to the control group (P>0.05), irrespective of universal adhesive types. CONCLUSIONS: HA-based desensitizing agents can occlude the exposed dentinal tubules on sensitive dentin. When mild and ultra-mild universal adhesives were used for subsequent resin restoration, the bond strength was reduced by HA-based desensitizing toothpastes, whereas the pure HA paste had no adverse effect on bond strength.


Assuntos
Dentina , Cremes Dentais , Humanos , Dentina/química , Durapatita/farmacologia , Cimentos Dentários/farmacologia , Cimentos Dentários/análise , Resistência à Tração
9.
Sci Rep ; 12(1): 18299, 2022 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-36316522

RESUMO

Cosmetic and personal care products are considered an essential part of our daily care routine; hence, these products must be stable and safe for human use. This study aimed to assess the quality and safety of the most common cosmetic preparations. To select the products to be tested, a cross-sectional survey was distributed featuring the most used types and brands of products. Based on 447 responses from both males and females with different ages and education levels, 21 products from different brands were selected and tested in terms of microbial load, heavy metal content, and organoleptic properties. Microbial contamination was investigated using the aerobic plate count method. Lead (Pb), aluminum (Al), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), zinc (Zn), iron (Fe), and arsenic (As) impurities were analyzed using an inductively coupled plasma mass spectrometer. The products included sunblock, lip balm, hand cream, hair cream, shampoo, cleanser, baby oil, baby powder, bar soap, hair dye, makeup, deodorant, hair serum, shaving gel, and toothpaste. Microbial contamination was found in 14 of the products, ranging between 1467.5 and 299.5 cfu/ml. The most commonly isolated microorganisms were Staphylococcus aureus and Bacillus species. Most of the tested products showed metal impurities, with toothpaste having the highest concentrations of Pb, Cr, As, Cu and Ni. The samples did not show lumps or discoloration, did not have characteristic odors, and had pH values ranging from 6.90 to 8.10. The continuous usage of such products could lead to serious negative consequences. As a result, ensuring the quality of cosmetic products is critical. Regulatory authorities are required to enforce strict legislation on cosmetic manufacturing to assess and ensure the quality and safety of the products before they reach consumers.


Assuntos
Arsênio , Cosméticos , Metais Pesados , Masculino , Feminino , Humanos , Cremes Dentais , Estudos Transversais , Chumbo , Metais Pesados/análise , Cádmio/análise , Cosméticos/análise , Cromo/análise , Níquel/análise , Monitoramento Ambiental
10.
BMC Oral Health ; 22(1): 465, 2022 11 03.
Artigo em Inglês | MEDLINE | ID: mdl-36329457

RESUMO

BACKGROUND: There is little is known about the factors associated with caries experience and gingivitis among 6-11-year-old children in Nigeria. The aim of the study was to determine the prevalence and preventive oral health behaviors associated with caries and gingivitis among 6-11-year-old children in Nigeria. METHODS: A cross-sectional questionnaire-based survey was conducted in Ile-Ife, Nigeria. The dependent variables were caries and gingivitis. The dmft/DMFT index was used to assess dental caries experience (present or absent) and caries severity. The gingival index was used to assess the prevalence (present or absent) and severity of gingivitis (healthy gingiva/mild gingivitis versus moderate/severe gingivitis). The independent variables were preventive oral health behaviors (frequency of daily tooth brushing, frequency of consumption of refined carbohydrates in-between-meals, use of fluoridated toothpaste, and use of dental floss, history of dental service utilization). A series of logistic regression analysis models were constructed to determine the associations between the dependent and independent variables after adjusting for confounders (age, sex, and socioeconomic status). RESULTS: There were 69 (5.2%) children with caries. The mean (standard deviation) dmft was 0.08 (0.457) and the mean DMFT was 0.02 (0.159). There were 839 (63.3%) children with gingivitis with a mean (SD) gingival index score of 0.503 (0.453). Children who seldom or never used fluoride toothpaste had significantly higher odds of developing moderate to severe gingivitis (AOR; 1.671; 95% CI: 1.003-2.786; p = 0.049). Children with middle socio-economic status had significantly lower odds of developing moderate to severe gingivitis (AOR: 0.573; 95%CI: 0.330-0.994; p = 0.048). There were no risk indicators identified for caries. CONCLUSION: The prevalence of dental caries was low while the prevalence of gingivitis was high in the study population. The daily used of fluoridated toothpaste seem to reduce the risk for moderate/severe gingivitis. Further studies are needed to understand these findings.


Assuntos
Cárie Dentária , Gengivite , Criança , Humanos , Cárie Dentária/prevenção & controle , Cremes Dentais/uso terapêutico , Estudos Transversais , Nigéria/epidemiologia , Gengivite/epidemiologia , Prevalência , Índice CPO
11.
Int J Mol Sci ; 23(19)2022 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-36232730

RESUMO

Hygiene is essential to avoid diseases, and this is thanks to daily cleaning and disinfection habits. Currently, there are numerous commercial products containing antimicrobial agents, and although they are efficient in disinfecting, it is still not known the effect of the constant use of these products on human health. In fact, a massive use of disinfectants has been observed due to COVID-19, but the possible adverse effects are not yet known. Triclosan is one of the antimicrobial agents used in cosmetic products, toothpaste, and disinfectants. This compound is an endocrine disruptor, which means it can interfere with hormonal function, with its estrogenic and androgenic activity having already been stated. Even if the use of triclosan is well-regulated, with the maximum allowed concentration in the European Union of 0.3% (m/m), its effects on human health are still uncertain. Studies in animals and humans suggest the possibility of harmful health outcomes, particularly for the reproductive system, and in a less extent for the cardiovascular and thyroid functions. Thus, the purpose of this review was to analyse the possible implications of the massive use of triclosan, mainly on the reproductive and cardiovascular systems and on the thyroid function, both in animals and humans.


Assuntos
Anti-Infecciosos Locais , COVID-19 , Sistema Cardiovascular , Desinfetantes , Disruptores Endócrinos , Triclosan , Animais , Anti-Infecciosos Locais/efeitos adversos , Disruptores Endócrinos/toxicidade , Humanos , Glândula Tireoide , Cremes Dentais , Triclosan/efeitos adversos
12.
Braz Oral Res ; 36: e0124, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36228223

RESUMO

The aim of this cross-sectional study was to evaluate how much pediatric dentists know about the noninvasive, micro, and minimally invasive strategies for managing caries lesions in deciduous teeth. An electronic questionnaire was sent to pediatric dentists enrolled in the Regional Board of Dentistry. Information was collected concerning: 1) characteristics of the participants; 2) level of updated knowledge of noninvasive, micro and minimally invasive procedures for caries management in children; 3) agreement to sentences on the indicated procedures. The data were analyzed descriptively and with bivariate tests. Seventy pediatric dentists participated. Results showed high frequency of agreement with sentences on strategies for lesion caries management: 92.8% with the sentence on selective removal of decayed tissue; 90.0% on fluoridated toothpaste (≥1,000 ppm); 84.3% on silver diamine fluoride (SDF); 80.0% on the Hall technique; and 76.9% on the sealing of small dentine lesions. Level of agreement with sentences was not significantly related to variables of time since graduation, degree of updatedness, area of employment, or higher education degree (p > 0.05). A higher score on agreement toward SDF use was accompanied by a greater degree of self-declared updatedness on noninvasive, micro and minimally invasive procedures for caries management in children (rho 0.259; p = 0.031). Pediatric dentists consider themselves updated and agree with the sentences on recommended use of fluoridated toothpaste as of eruption of the first tooth, and on the selective removal of decayed tissue. Disagreement still continues regarding application of SDF to arrest lesion progression, sealing of small dentin lesions, and the Hall technique.


Assuntos
Cárie Dentária , Cremes Dentais , Cariostáticos/uso terapêutico , Criança , Estudos Transversais , Cárie Dentária/patologia , Cárie Dentária/terapia , Odontólogos , Fluoretos Tópicos/uso terapêutico , Humanos , Compostos de Amônio Quaternário , Compostos de Prata , Dente Decíduo
13.
PLoS One ; 17(10): e0276227, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36251665

RESUMO

In home care, the toothpaste technique, which can enhance the caries-preventive effect without changing the amount of dentifrice and fluoride ion concentration, is of great significance. This study aimed to construct a model and experimental system that reproduces the interdental part and to clarify the relationship between the change in dentifrice viscosity due to dilution and washout in the high-risk approximal area of caries. Additionally, the effectiveness of the toothpaste technique and appropriate devices for delivering dentifrice to the interdental area at a low dilution were investigated. Diluted toothpaste samples were prepared (: ×1.00, ×1.25, ×1.50, ×1.75, ×2.00, ×3.00, and ×4.00). An acrylic interproximal model was created for this experiment. The flow characteristics and viscosity by dentifrice dilution were measured. In the case of low dilution of 57% (1.75×) or more, it was shown that the dentifrice in the high-risk area may be washed out early because of the decrease in viscosity, and the caries-preventive effect may be reduced. It was also suggested that to keep the dentifrice in the interdental area for 120 s at the end of brushing, a dilution must be devised to a concentration of at least 50% (2.00×). The prepared toothpaste delivery (PTD) method of delivering dentifrice to the interdental area while maintaining it at a low dilution is an effective toothpaste technique in terms of dentifrice dilution and viscosity. The use of finger brushes in the PTD method could increase the efficiency of dentifrice delivery.


Assuntos
Dentifrícios , Fluoretos , Técnicas de Diluição do Indicador , Fluoreto de Sódio , Escovação Dentária/métodos , Cremes Dentais
14.
Sci Rep ; 12(1): 17119, 2022 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-36224315

RESUMO

Globally 3 billion people are consuming water with moderately high concentrations of fluoride and arsenic. The development of a simple point of care (PoC) device or home device for the detection of fluoride/arsenic ensures safety before consuming water. Till date, lateral flow assay (LFA) based PoC devices can detect nucleic acids, viruses and diseases. An aluminium complex of rhodamine B functionalized oxacalix[4]arene (L) was designed to execute the LFA-based PoC device. Initially, Al3+ and Fe3+ ions were involved in complexation with the rhodamine B functionalized oxacalix[4]arene (L), resulting C1 (L-Al3+) and C2 (L-Fe3+) complexes respectively. The receptor L, as well as the probes (C1, C2), were characterized thoroughly using mass spectroscopy, FTIR, NMR, and EA. C1 and C2 were further utilized as recyclable probes for the detection of aqueous fluoride (21 ppb) and arsenate (1.92 ppb) respectively. The computational calculation indicates that upon complexation, the spirolactam ring opening at the rhodamine B site leads to optoelectronic changes. The consistency of LFA-based portable sensing device has been tested with water samples, synthetic fluoride standards and dental care products like toothpaste and mouthwash with concentrations ≥ 3 ppm. Moreover, fixed cell imaging experiments were performed to ascertain the in-vitro sensing phenomena.


Assuntos
Arsênio , Ácidos Nucleicos , Alumínio , Arseniatos , Colorimetria/métodos , Fluoretos , Humanos , Antissépticos Bucais , Cremes Dentais , Água/química
15.
Artigo em Inglês | MEDLINE | ID: mdl-36231733

RESUMO

BACKGROUND: Due to a dearth of information on preventive and supportive oral care for people with Down Syndrome (PDS) in Germany, caregivers of PDS were surveyed on the topic. METHODS: An anonymized questionnaire was sent to the 610 members of the German Down Syndrome Association. The study was approved by the ethics committee of Witten/Herdecke University (# 165/2017). RESULTS: The parents/caregivers of 207 PDS responded. These PDS were between 1 and 55 years old (mean age 24.4 years) and included 111 males and 96 females. At their first dental appointment, 40.7% (n = 82) had been younger than three years. Although 78.3% (n = 162) tooth brushed twice daily, only 30.9% (n = 64) brushed for 2-3 min; 84.0% (n = 135) did not use other dental hygiene products apart from toothbrushes. Age-specific differences were found: Although only 30.8% (n = 12) of PDS < 18 years (n = 39) independently performed dental self-care; this was 67.3% (n = 113) for PDS ≥ 18 years (n = 168). A statistically significant (p < 0.001; Chi-Square-Test) difference in toothbrush preferences emerged: While PDS < 18 years mainly used manual toothbrushes, PDS ≥ 18 years preferred electric toothbrushes. In contrast to 72.6% of PDS ≥ 18 years, only 51.3% of PDS < 18 years accepted most types of toothpaste. CONCLUSIONS: Age-dependent differences in tooth brushing behaviour became evident within the group of PDS in Germany. Hence, better age-specific, inter-professional dental prophylaxis concepts need to be developed and offered for all age groups of PDS. These concepts should include personalized check-up intervals and hands-on instruction in dental hygiene procedures by dental practitioners.


Assuntos
Síndrome de Down , Cremes Dentais , Adolescente , Adulto , Criança , Pré-Escolar , Atenção à Saúde , Odontólogos , Feminino , Alemanha/epidemiologia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Saúde Bucal , Papel Profissional , Escovação Dentária , Cremes Dentais/uso terapêutico , Adulto Jovem
16.
Food Res Int ; 161: 111846, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36192975

RESUMO

Propolis is a rich source of known and largely explored bioactive compounds with many pharmacological properties. It is used in several commercialized products, such as propolis-enriched honey, candies, mouth and throat sprays, soaps, toothpaste, and skin creams. However, the great diversity of propolis products and different types make the standardization of realistic quality control procedures challenging. Moreover, the extraction of propolis bioactive compounds depends on the technique and the solvent used. In Brazil, the Ministry of Agriculture, Livestock, and Supply (MAPA) set standards to establish commercialized propolis extracts' identity and quality. In addition, according to legislation, propolis extracts must present the main classes of phenols at 200 and 400 nm on the UV spectrum. Still, it is not specified which analysis method should be used to guarantee feasible quality control of the commercialized samples. For this, we proposed a new fast UHPLC-PDA-MS/MS method for analysis and quantification of propolis phenolic compounds. Moreover, we hypothesize that there is no efficient monitoring regarding the quality of the propolis extracts sold in Brazilian stores. Therefore, the present study aimed to perform quality control of 17 Brazilian propolis extracts produced in the Southeast region (green or brown - the most representative samples). The dry extract content (% g/mL), oxidation index (seconds), total flavonoids, and phenolics (% m/m) of each sample were compared with legislation. We conclude that using the UHPLC-PDA method and the investigation that allowed the comparison with the current legislation efficiently practical problems in the commercialization of propolis extracts. However, of the 17 analyzed samples, 6 did not meet the desired the recognized standards, denoting a lack of supervision and efficient quality control, which highlights a dangerous situation regarding the commercialization of this critical product used in several industrial fields, mainly in the food and pharmaceutical sector.


Assuntos
Própole , Brasil , Cromatografia Líquida de Alta Pressão/métodos , Flavonoides/análise , Preparações Farmacêuticas , Fenóis/análise , Extratos Vegetais , Própole/farmacologia , Controle de Qualidade , Padrões de Referência , Sabões/análise , Solventes , Espectrometria de Massas em Tandem , Cremes Dentais/análise
17.
PLoS One ; 17(10): e0275111, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36260605

RESUMO

BACKGROUND: Fluoride toothpaste (FT) has recently been included in the WHO Model List of Essential Medicines. Whereas it is essential for preventing dental caries, its current affordability around the globe remains unclear. This study aimed to analyse the affordability of FT in as many as possible countries worldwide, to capture the extent of variations in FT affordability between high-, middle- and low-income countries. METHODS: A standardized protocol was developed to collect country-specific information about the characteristics of the cheapest available FT at a regular point of purchase. 82 members of the WHO Global Oral Health Network of Chief Dental Officers (CDOs), directors of WHO Collaborative Centres and other oral health experts collected data using mobile phone technology. In line with established methodologies to assess affordability, the Fluoride Toothpaste Affordability Ratio (FTAR) was calculated as the expenditure associated with the recommended annual consumption of FT relative to the daily wage of the lowest-paid unskilled government worker (FTAR >1 = unaffordable spending on fluoride toothpaste). RESULTS: There are significant differences in the affordability of FT across 78 countries. FT was strongly affordable in high-income countries, relatively affordable in upper middle-income countries, and strongly unaffordable in lower middle-income and low-income countries. The affordability of FT across WHO Regions was dependent upon the economic mix of WHO Regions' member states. CONCLUSION: FT is still unaffordable for many people, particularly in low-income settings. Strategies to improve the universal affordability of FT should be part of health policy decisions in order to contribute to reducing dental caries as a global public health problem.


Assuntos
Cárie Dentária , Medicamentos Essenciais , Humanos , Cremes Dentais , Fluoretos , Cárie Dentária/prevenção & controle , Acesso aos Serviços de Saúde , Custos e Análise de Custo
18.
Artigo em Inglês | MEDLINE | ID: mdl-36293818

RESUMO

This study aimed to compare the fluoride intake and salivary fluoride levels after brushing with conventional (1400-1450 ppm) fluoride toothpaste containing different fluoride agents: amine fluoride (AmF), sodium fluoride (NaF), sodium monofluorophosphate (SMFP), potassium fluoride (KF), and a high-fluoride (5000 ppm) toothpaste containing NaF. Fourteen volunteers took part in the study. They were instructed to brush and spit without rinsing after using conventional toothpaste or brush and rinse with water after using a high-fluoride toothpaste. Fluoride concentrations were determined using ion-selective fluoride (09-37 type) in the saliva samples before and after procedures. Fluoride intake was estimated based on fluoride recovered after brushing. Additionally, the amount of fluoride present in the oral fluids and lost during the rapid clearance phase after toothbrushing was calculated based on salivary fluoride levels and saliva flow immediately after brushing. Salivary fluoride after using high-fluoride toothpaste was significantly higher than those observed after conventional products. Two hours after brushing, salivary fluoride concentrations did not differ significantly from baseline values (p > 0.05) unless a high-fluoride product was used. Results indicate that by refraining from rinsing after brushing with conventional toothpaste, we cannot obtain fluoride retention in saliva as with high-fluoride toothpaste. Fluoride ingestion was higher after using a high-fluoride product.


Assuntos
Fluoretos , Cremes Dentais , Humanos , Escovação Dentária , Fluoreto de Sódio , Cariostáticos , Água , Antissépticos Bucais , Saliva/química , Aminas
19.
BMC Oral Health ; 22(1): 451, 2022 10 24.
Artigo em Inglês | MEDLINE | ID: mdl-36280822

RESUMO

BACKGROUND: While supervised toothbrushing programmes have been established in many countries of the world, little is known about different perspectives on their implementation. The aim of the study was to explore stakeholders' barriers and facilitators to implementation of a school-based toothbrushing programme in Taiwan. METHODS: Focus groups and interviews were used to explore the views of elementary school students, teachers, staff, and nurses in a piloted school-based toothbrushing programme. The topic guides were developed according to the Theoretical Domains Framework (TDF) to cover the behavioural factors systematically and comprehensively. Data were analysed with content analysis. RESULTS: Overall, 36 students, 29 teachers/staff, and five school nurses (N = 65) were included. The overarching theme was the importance of habit formation for both staff and children to ensure that toothbrushing as part of the programme was embedded into the school schedule and routine. While children did not necessarily appear to retain the dental knowledge which was taught in the programme, the provision of fluoride toothpaste and toothbrush for their use in schools allowing teachers and staff to choose the timing of the brushing and engaging classmates to supervise each other were found to be key factors. CONCLUSIONS: Implementing a school-based toothbrushing programme with the support of staff and active engagement of children can help children to develop a toothbrushing habit. Classmate-supervised toothbrushing may reduce the burden on teachers and staff to implement the programme.


Assuntos
Escovação Dentária , Cremes Dentais , Criança , Humanos , Fluoretos , Instituições Acadêmicas , Pesquisa Qualitativa
20.
Biomolecules ; 12(10)2022 09 21.
Artigo em Inglês | MEDLINE | ID: mdl-36291543

RESUMO

Titanium dioxide nanoparticles (TiO2NPs) are found in a wide range of products such as sunscreen, paints, toothpaste and cosmetics due to their white pigment and high refractive index. These wide-ranging applications could result in direct or indirect exposure of these NPs to humans and the environment. Accordingly, conflicting levels of toxicity has been associated with these NPs. Therefore, the risk associated with these reports and for TiO2NPs produced using varying methodologies should be measured. This study aimed to investigate the effects of various media on TiO2NP properties (hydrodynamic size and zeta potential) and the effects of TiO2NP exposure on human colorectal adenocarcinoma (Caco-2) epithelial cell viability, inflammatory and cell stress biomarkers and angiogenesis proteome profiles. The NPs increased in size over time in the various media, while zeta potentials were stable. TiO2NPs also induced cell stress biomarkers, which could be attributed to the NPs not being cytotoxic. Consequently, TiO2NP exposure had no effects on the level of inflammatory biomarkers produced by Caco-2. TiO2NPs expressed some anti-angiogenic properties when exposed to the no-observed-adverse-effect level and requires further in-depth investigation.


Assuntos
Adenocarcinoma , Neoplasias Colorretais , Nanopartículas , Humanos , Células CACO-2 , Protetores Solares , Cremes Dentais , Proteoma , Titânio/toxicidade , Nanopartículas/toxicidade , Biomarcadores
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