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1.
Medicine (Baltimore) ; 99(36): e21622, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32898997

RESUMO

The objective of the study was to characterize self-reported oral hygiene practices among Mexican older adults aged ≥60 years, and to measure the association between frequency of tooth brushing and a set of sociodemographic, socioeconomic, and dental variables.We conducted a cross-sectional study of 139 older adults aged ≥60 years in Pachuca, Mexico. A questionnaire and a clinical dental examination were administered to identify specific variables. We determined frequency of tooth brushing (or cleaning of dentures or prostheses) and use of toothpaste, mouthwash, and dental floss among respondents. Non-parametric testing was performed for statistical analysis and a multivariate logistic regression model was generated with Stata 11 software to determine frequency of tooth brushing.In our study sample, 53.2% of participants reported brushing their teeth at least once a day, 50.4% always using toothpaste, 16.5% using mouthwash and 3.6% using floss for their oral hygiene. In general, younger and female respondents used oral hygiene aids more than the others. Our multivariate model yielded an association (P < .05) between tooth brushing at least once daily and the following variables: having functional dentition (OR = 12.60), lacking health insurance (OR = 3.72), being retired/pensioned (OR = 4.50), and suffering from a chronic disease (OR = 0.43).The older adults in our sample exhibited deficient oral hygiene behaviors. The results suggest certain socioeconomic inequalities in oral health. The findings of this study should be considered when designing dental care instructions for older adults.


Assuntos
Escovação Dentária/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Dispositivos para o Cuidado Bucal Domiciliar , Feminino , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Antissépticos Bucais/administração & dosagem , Autorrelato , Fatores Socioeconômicos , Cremes Dentais/administração & dosagem
2.
Rev. cuba. estomatol ; 56(4): e1825, oct.-dez. 2019. tab
Artigo em Espanhol | LILACS | ID: biblio-1093247

RESUMO

RESUMEN Introducción: Durante la gestación, algunos cambios fisiológicos en la mujer propician un incremento de la placa dental y de la microbiota cariogénica. Esta condición unida a una modificación de la dieta y a una inadecuada higiene bucal condicionarían desfavorablemente la salud oral tanto de la madre como del bebé. Objetivo: Determinar el efecto antibacteriano de una pasta dental con xilitol sobre el recuento de Streptococcus mutans en saliva de gestantes. Métodos: Ensayo clínico, a doble ciego, que se realizó en el Centro de Salud "José Olaya" (Chiclayo Perú), en enero de 2017. Se trabajó con una población muestral de 50 gestantes en el segundo trimestre que cumplieron con los criterios establecidos. Se crearon dos grupos: 25 gestantes usaron dentífrico con 10 por ciento de xilitol y 25 gestantes usaron dentífrico sin xilitol. Se les tomó y proceso microbiológicamente una muestra de saliva antes del inicio del estudio y 14 días después del uso de las respectivas pastas. Se realizó el recuento de unidades formadoras de colonias de Streptococcus mutans en saliva con una confiabilidad altamente significativa mediante el coeficiente de correlación intraclase, calibración intra e interexaminador (1,000 y 0,999, respectivamente). El análisis de los datos se realizó mediante la prueba U de Mann-Whitney, considerando un nivel de significancia del 5 por ciento. Resultados: No se encontró diferencia significativa entre las gestantes que emplearon pasta dental con xilitol en comparación con las que utilizaron pasta dental sin xilitol (p= 0,062). Conclusiones: El efecto antibacteriano de la pasta dental comercial con xilitol es similar a una pasta dental sin xilitol sobre el recuento de Streptococcus mutans en saliva de gestantes(AU)


ABSTRACT Introduction: Some physiological changes occur in women during pregnancy which cause an increase in dental plaque and cariogenic microbiota. This situation, alongside a modification in the diet and inadequate oral hygiene, negatively affect the oral health of both the mother and the baby. Objective: Determine the antibacterial effect of a toothpaste with xylitol on the count of Streptococcus mutans in pregnant women's saliva. Methods: A double-blind clinical trial was conducted in José Olaya Health Center (Chiclayo, Peru) in January 2017. The sample population was 50 women in the second trimester of pregnancy who met the established inclusion criteria. Two groups were formed: 25 pregnant women used a toothpaste with 10 percent xylitol and the other 25 used a toothpaste without xylitol. A saliva sample was taken and processed microbiologically before the start of the study and 14 days after use of the two toothpastes. A count was performed of colony-forming units for Streptococcus mutans in saliva with highly significant reliability, using the intraclass correlation coefficient, and intra- and inter-rater calibration (1.000 and 0.999, respectively). Data analysis was based on the Mann-Whitney U Test, with a significance level of 5 percent. Results: No significant difference was found between the pregnant women who used the toothpaste with xylitol and those who used the toothpaste without xylitol (p= 0.062). Conclusions: The antibacterial effect of the commercial toothpaste with xylitol is similar to that of a toothpaste without xylitol in terms of the Streptococcus mutans count in pregnant women's saliva(AU)


Assuntos
Humanos , Feminino , Gravidez , Streptococcus mutans/citologia , Cremes Dentais/administração & dosagem , Placa Dentária/epidemiologia , Antibacterianos/uso terapêutico
4.
Acta Odontol Scand ; 77(5): 386-393, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30784350

RESUMO

OBJECTIVES: The present study addresses the effect of fluoride and sodium lauryl sulphate content of toothpaste on oral epithelial cells in vivo conditions. SUBJECTS AND METHOD: Forty volunteers were assigned into two experimental groups, each of them applying the different brand of toothpaste. Every group has been using three different types of toothpaste (non-fluoride and non-SLS, fluoride and non-SLS, and the fluoride and SLS) of the same brand for 6 months, each for 2 months. The buccal epithelial cells were sampled at baseline and 30, 60, 90, 120, 150 and 180 days after the beginning of the research. Effect on DNA damage was analyzed by micronucleus assay Results: After 60 days of use, for both tested kinds of toothpaste with fluoride and without SLS, all studied parameters were not significantly different from the results obtained at the time when the participants used a non-fluoride toothpaste. While, after 60 days of use, for one kind of toothpaste with SLS and fluoride, was observed significantly higher incidence of pyknotic cells (2.20 ± 0.95, 0.00 ± 0.00 vs. 0.05 ± 0.22, respectively; p = .001), cells with karyorrhexis (2.35 ± 1.14, 0.85 ± 0.93 vs. 0.40 ± 0.68, respectively; p = .001), and nuclear buds (1.35 ± 0.68, 0.45 ± 0.51 vs. 0.45 ± 0.60, respectively; p = .001), compared to toothpastes of the same brand with fluoride and without SLS, and without fluoride and without SLS, for the same period. CONCLUSIONS: Based on the results, can be concluded that there is no fluorine-dependent cytotoxic or genotoxic effect, while SLS dentifrice increases the number of nuclear morphological changes in buccal epithelial cells.


Assuntos
Células Epiteliais/efeitos dos fármacos , Fluoretos/efeitos adversos , Mucosa Bucal/efeitos dos fármacos , Dodecilsulfato de Sódio/administração & dosagem , Tensoativos/efeitos adversos , Cremes Dentais/administração & dosagem , Dentifrícios , Feminino , Fluoretos/administração & dosagem , Humanos , Masculino , Dodecilsulfato de Sódio/efeitos adversos , Tensoativos/administração & dosagem , Cremes Dentais/efeitos adversos , Adulto Jovem
5.
MMWR Morb Mortal Wkly Rep ; 68(4): 87-90, 2019 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-30703075

RESUMO

Fluoride use is one of the main factors responsible for the decline in prevalence and severity of dental caries and cavities (tooth decay) in the United States (1). Brushing children's teeth is recommended when the first tooth erupts, as early as 6 months, and the first dental visit should occur no later than age 1 year (2-4). However, ingestion of too much fluoride while teeth are developing can result in visibly detectable changes in enamel structure such as discoloration and pitting (dental fluorosis) (1). Therefore, CDC recommends that children begin using fluoride toothpaste at age 2 years. Children aged <3 years should use a smear the size of a rice grain, and children aged >3 years should use no more than a pea-sized amount (0.25 g) until age 6 years, by which time the swallowing reflex has developed sufficiently to prevent inadvertent ingestion. Questions on toothbrushing practices and toothpaste use among children and adolescents were included in the questionnaire component of the National Health and Nutrition Examination Survey (NHANES) for the first time beginning in the 2013-2014 cycle. This study estimates patterns of toothbrushing and toothpaste use among children and adolescents by analyzing parents' or caregivers' responses to questions about when the child started to brush teeth, age the child started to use toothpaste, frequency of toothbrushing each day, and amount of toothpaste currently used or used at time of survey. Analysis of 2013-2016 data found that >38% of children aged 3-6 years used more toothpaste than that recommended by CDC and other professional organizations. In addition, nearly 80% of children aged 3-15 years started brushing later than recommended. Parents and caregivers can play a role in ensuring that children are brushing often enough and using the recommended amount of toothpaste.


Assuntos
Escovação Dentária/estatística & dados numéricos , Cremes Dentais/administração & dosagem , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Inquéritos Nutricionais , Estados Unidos
6.
Aging Clin Exp Res ; 31(12): 1817-1825, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30680547

RESUMO

BACKGROUND: Elderly people are at risk for vitamin B12 deficiency. AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects. METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months. RESULTS: 92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data analysis. After the intervention, concentrations of vitamin B12 were higher [mean (SD) = 368 (123) vs. 295 (123) pmol/L; p = 0.005] and holoTC tended to be higher [112 (48) vs. 91 (68) pmol/L; p = 0.088] in the vitamin B12 group compared with the placebo group. The changes of serum vitamin B12 [54 (74) vs. 3 (60) pmol/L, p < 0.001], holoTC [21 (34) vs. 2 (32) pmol/L, p = 0.007], and tHcy [- 0.9 (2.3) vs. 0.3 (1.9) µmol/L, p = 0.010] were significantly different between the intervention groups. Mean percentage increase of serum vitamin B12 (+ 23% corresponds to + 54 pmol/L) in the vitamin B12 toothpaste group suggests that the intervention had provided an additional daily intake of approximately + 7 µg oral B12. Common diseases and drugs did not predict the change of blood markers in the vitamin group. No side effects were observed. CONCLUSIONS: The toothpaste enriched with 100 µg cyanocobalamin/g has increased vitamin B12 status and can thus be used for preventing vitamin B12 depletion in elderly people. The trial was registered at ClinicalTrials.gov: NCT02679833.


Assuntos
Cremes Dentais/administração & dosagem , Deficiência de Vitamina B 12/prevenção & controle , Vitamina B 12/administração & dosagem , Complexo Vitamínico B/administração & dosagem , Idoso , Biomarcadores/sangue , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vitamina B 12/farmacologia , Deficiência de Vitamina B 12/sangue , Complexo Vitamínico B/farmacologia
7.
J Appl Res Intellect Disabil ; 32(3): 657-665, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30632693

RESUMO

BACKGROUND: A visual-verbal integration model (VVIM) was used to train parents and their children with intellectual and developmental disabilities (IDD) to dispense a pea-sized amount of fluoridated toothpaste, aiming to balance the occurrence of dental caries and fluorosis. METHOD: Participants were 370 pairs of IDD preschool children and their parents. A two-phase pre-post-intervention study was performed. The weight of toothpaste was calculated by a portable electronic compact balance. RESULTS: A quarter of parents and <20% children dispensed the appropriate amount at baseline. Almost 85% parents and 50% children achieved the pea-sized amount after intervention. Half of the children continued to use the recommended toothpaste amount after 6 months. Children with higher intellectual functioning and conceptual skills were more likely to dispense the pea-sized amount of toothpaste. CONCLUSIONS: Visual-verbal integration model training had a desired impact on parents' toothpaste-dispensing performance. Children with higher adaptive skills may benefit from VVIM training.


Assuntos
Cárie Dentária/prevenção & controle , Deficiências do Desenvolvimento , Fluorose Dentária/prevenção & controle , Deficiência Intelectual , Educação de Pacientes como Assunto/métodos , Escovação Dentária , Cremes Dentais/administração & dosagem , Pré-Escolar , Feminino , Humanos , Masculino , Pais
9.
Int Dent J ; 69(1): 58-66, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30028021

RESUMO

PURPOSE: Non-invasive treatment of root caries lesions (RCLs) may impact oral health-related quality of life (OHRQoL), but no evidence is available. The purpose of the study was to assess changes in OHRQoL among patients exposed to non-invasive treatment of RCLs with conventional or high-fluoride dentifrices. METHODS: To be eligible, subjects had to be ≥60 years of age, independently living, with at least five teeth and one RCL. The 14-item Oral Health Impact Profile for adults in Spanish (OHIP-14Sp), oral examination and sociodemographic data were documented at the beginning of the study (T0). The presence and activity of RCLs were detected and diagnosed. Subjects were randomly assigned to either the control (1,450 ppm fluoride) or the experimental (5,000 ppm fluoride) treatment group. A new set of measurements was obtained at 12 months (T1). Mean comparisons were carried out using the Student's t-test for total OHIP-14Sp scores. To determine whether T1 OHRQoL scores were different regarding sex, age, educational level and socio-economic status, mean OHIP-14Sp scores were obtained and compared with those variables at 12 months. RESULTS: An overall improvement in OHRQoL after the non-invasive treatment of RCLs was verified when T1 was compared with T0 (P < 0.0001). Regarding treatment type, no significant differences were detected between groups (P = 0.114). Subjects with higher income and more years of formal education had better OHRQoL than those with a lower salary (P < 0.0001) and with fewer years of education (P = 0.0006). CONCLUSIONS: Non-invasive treatment for RCLs in community-dwelling elders appears to cause a positive impact on OHRQoL. Better OHRQoL was associated with higher socio-economic status and educational level. No significant differences were detected regarding the fluoride concentration in the dentifrices.


Assuntos
Fluoretos/administração & dosagem , Vida Independente , Saúde Bucal , Qualidade de Vida , Cárie Radicular/prevenção & controle , Cremes Dentais/administração & dosagem , Idoso , Inquéritos de Saúde Bucal , Status Econômico , Escolaridade , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Autoadministração
10.
Oral Health Prev Dent ; 16(4): 307-314, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30175328

RESUMO

PURPOSE: To determine the efficacy of high-fluoride toothpastes (≥ 2500 ppm) as compared to standard fluoride toothpastes (≤ 1500 ppm) in preventing dental caries. MATERIALS AND METHODS: Randomised controlled trials (RCTs) and cluster-randomised trials comparing high-fluoride dentifrices (≥ 2500 ppm) with lower-concentration fluoride dentifrices (≤ 1500 ppm) with a follow-up period of at least 6 months were included. A random effects model was used to assess the mean differences in caries increment between the two types of dentifrices used. A fixed effects model was used to determine the preventive effect of high-concentration fluoride toothpastes compared with low-fluoride toothpastes. Subgroup and sensitivity analyses were conducted when results indicated heterogeneity. Statistical significance was set at p < 0.05. RESULTS: Eight studies met the inclusion criteria. High-fluoride toothpaste use was statistically significantly associated with lower caries increment scores (pooled mean difference: -0.52 [95% CI, -0.67, -0.37], p = 0.00001). Subgroup analysis for the included studies reflected a significant reduction in I2 values from 99% to 18%. High-fluoride toothpastes were also associated with a greater preventive effect compared with low-fluoride toothpastes (pooled odds: 52.76 [95% CI, 19.74, 141.04], p = 0.95). CONCLUSION: This meta-analysis suggests that high-fluoride toothpastes are superior to low-fluoride toothpastes in reducing caries. The results of this work when used judiciously should encourage the use of high-fluoride toothpaste, specifically among the vulnerable populations, to maximise preventive benefits.


Assuntos
Cariostáticos/administração & dosagem , Cárie Dentária/prevenção & controle , Fluoretos/administração & dosagem , Cremes Dentais/administração & dosagem , Relação Dose-Resposta a Droga , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
11.
Indian J Dent Res ; 29(4): 487-496, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30127201

RESUMO

Objective: The aim of this systematic review was to assess the long term remineralizing potential of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) only in paste form compared with fluoride varnish, and or placebo in both naturally occurring and post-orthodontic white spot lesions in vivo. Data Sources: The literature search covered the electronic databases: PubMed and Google scholar from 2005-2016. Only articles published in English were included. Randomized control trials in which CPP-ACP delivered by paste form were included. All studies which met inclusion criteria underwent two independent reviews. Study Selection: Two ninety five articles were identified from the search after excluding duplications. Abstracts of forty one articles were reviewed independently. Twenty nine articles were excluded after reading abstract. Full text articles were retrieved for fifteen relevant studies. After reviewing articles independently, three articles were excluded after full text reading. Finally twelve studies were selected based on the eligibility criteria. The remineralizing effect of CPP-ACP were compared with placebo and fluoridated toothpaste and fluoride varnish in randomized control trial. Conclusion: A high level evidence of remineralizing potential of CPP-ACP on naturally occurring white spot lesion and WSL post orthodontic treatment was found in comparison with placebo/fluoridated toothpaste and fluoride varnish without any statistically significant difference. Well-designed RCTs are, therefore, required to improve the level of evidence in this area.


Assuntos
Caseínas/administração & dosagem , Cárie Dentária/tratamento farmacológico , Cárie Dentária/reabilitação , Esmalte Dentário , Remineralização Dentária/métodos , Cremes Dentais/administração & dosagem , Bases de Dados Bibliográficas , Cárie Dentária/etiologia , Cárie Dentária/prevenção & controle , Fluoretos/administração & dosagem , Humanos , Ortodontia
12.
Oral Health Prev Dent ; 16(2): 175-181, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29736497

RESUMO

PURPOSE: This double-blind, clinical, cross-over study evaluated the antibacterial effect of three toothpastes (ASF, HTP and STP) and a chlorhexidine mouthrinse (0.2%; CHX; positive control) after a single application on established biofilm over a period of 24 h (substantivity). MATERIALS AND METHODS: Twenty-four subjects refrained from all oral hygiene measures for a period of 72 h. After 48 h, a baseline biofilm sample was taken and vitality of the biofilm flora was examined (baseline, VF0). Then they rinsed for 1 min with one of the randomly allocated, freshly prepared toothpaste slurries (ASF, HTP, STP) or CHX. Further biofilm samples were taken every second hour up to 14 h as well as 24 h after rinsing, and biofilm vitality was assessed (VF2-24). After a wash-out period of 4 days, a new test cycle was started. RESULTS: All subjects (18 female, 6 male) finished the four test cycles. At VF2, all products showed a statistically significant reduction in vitality compared to VF0 (p<0.05). CHX and ASF revealed the most pronounced effect (49% and 40% reduction), while the other toothpastes (HTP: 24%, STP: 11%) reached lower but still statistically significant effects. At each further time point CHX and ASF showed the lowest biofilm vitality. ASF demonstrated a significant antibacterial effect on dental biofilm over a 24-h period compared to baseline and superiority over both other toothpastes at time points VF2-VF14. CONCLUSION: ASF toothpaste showed a significant antibacterial action on biofilm and a high substantivity which was maintained up to 24 hours.


Assuntos
Antibacterianos/farmacologia , Biofilmes/efeitos dos fármacos , Placa Dentária/microbiologia , Cremes Dentais/farmacologia , Adulto , Antibacterianos/administração & dosagem , Clorexidina/farmacologia , Estudos Cross-Over , Placa Dentária/prevenção & controle , Método Duplo-Cego , Feminino , Humanos , Masculino , Antissépticos Bucais/farmacologia , Qualidade de Vida , Cremes Dentais/administração & dosagem , Adulto Jovem
13.
J Contemp Dent Pract ; 19(11): 1295-1300, 2018 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-30602630

RESUMO

AIMS: Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed to evaluate the efficacy of two different pharmaceutical forms [toothpaste (TP) and mouthwash (MW)] of a new product containing chlorhexidine, dexpanthenol, allantoin and bioadhesive excipient (CDAB) (Bexident® Gums Coadjuvant Treatment) on volunteers with PD. Their preferences, acceptability and cosmetic properties, as well as tooth discoloration, were also assessed. MATERIALS AND METHODS: Total 60 subjects showing mild-moderate symptoms of gingivitis were randomly assigned to two different groups: one receiving TP (n = 30) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS). RESULTS: All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP)/36.7% (MW)] and from mild to negative [increase = 56.7% (TP)/50.0% (MW)]. After treatment, all subjects reported to have healthier and/or less bleeding teeth (TP 9.0/9.4; MW 8.0/8.2) and would recommend the product (TP:100%/MW:96.6%) with no specific preference regarding its presentation. No change of teeth color was observed. CONCLUSION: Subjects with PD who received oral care with a new formulation of either chlorhexidine-containing TP or MW for 21 days, reported a significant improvement of their symptoms and resolution of the gingivitis with no associated tooth discoloration. Patients did not show a specific preference for any of the pharmaceutical presentations. CLINICAL SIGNIFICANCE: This new formulation of a chlorhexidine-containing product in both TP and MW forms resulted effective for PD treatment and well accepted by the patients.


Assuntos
Clorexidina/administração & dosagem , Clorexidina/efeitos adversos , Antissépticos Bucais/administração & dosagem , Antissépticos Bucais/química , Doenças Periodontais/tratamento farmacológico , Cremes Dentais/administração & dosagem , Cremes Dentais/química , Adolescente , Adulto , Idoso , Feminino , Gengivite/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente , Doenças Periodontais/psicologia , Descoloração de Dente , Resultado do Tratamento , Adulto Jovem
14.
Acta Odontol Scand ; 76(1): 64-70, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28959909

RESUMO

OBJECTIVE: This study aimed to evaluate possible DNA damages to oral epithelial cells exposed to whitening kinds of toothpaste considering the effect of conventional non-whitening toothpaste. MATERIALS AND METHODS: Sixty volunteers were assigned into three experimental groups, each of them using a different regular toothpaste for the initial 2 months, followed by the use of whitening kind of toothpaste of the same brand for next 2 months. The oral epithelial cells were sampled prior and 30, 60, 90 and 120 days after the beginning of the use of tested kinds of toothpaste. Chromosomal damages were analyzed by micronucleus assay. RESULTS: For just one kind of tested whitening toothpaste was observed the significant increase in the number of micronucleated cells after 60 days of use compared values obtained 60 days of usage of conventional non-whitening toothpaste (6.35 ± 3.67 and 2.8 ± 1.91; p < .05). There was no statistically significant difference in other micronucleus assay endpoints between tested types of toothpaste at either of the sampling times during the period of toothpaste application. CONCLUSIONS: Based on the results, it can be concluded that the use of certain whitening kinds of toothpaste may cause a limited biologically insignificant genotoxic effect on buccal epithelial cells.


Assuntos
Testes de Carcinogenicidade , Mucosa Bucal , Clareamento Dental/efeitos adversos , Cremes Dentais/efeitos adversos , Adulto , Feminino , Humanos , Masculino , Mucosa Bucal/efeitos dos fármacos , Clareamento Dental/métodos , Cremes Dentais/administração & dosagem , Adulto Jovem
15.
J Dent ; 68: 59-65, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29097122

RESUMO

OBJECTIVE: This in situ study evaluated the effect of the association of low-F (4500µg F/g) gel containing TMP and FT (1100µg F/g) on enamel demineralization. METHODS: This crossover and double-blind study consisted of five phases of seven days each. Volunteers (n=12) wore palatal appliances containing four enamel blocks. The cariogenic challenge was performed with 30% sucrose solution (six times/day). Treatments were: placebo toothpaste (PT, no fluoride/TMP); 1100µg F/g toothpaste (FT); FT+4500µg F/g+5%TMP gel (FT+TMP gel); FT+9000µg F/g gel (FT+9000 gel) and FT+12,300µg F/g (FT+Acid gel). After topical application of treatments for one min, two blocks were removed for analysis of loosely bound fluoride (CaF2), calcium (Ca), phosphorus (P) and firmly bound fluoride (FA) formed in enamel. After the seven-day experimental periods, the percentage of surface hardness loss (%SH), integrated subsurface hardness loss (ΔKHN), CaF2, Ca, P and FA retained were determined. Moreover, the biofilms formed on the blocks were analyzed for F, Ca, P and insoluble extracellular polysaccharide (EPS) concentrations. RESULTS: FT+TMP gel promoted the lowest%SH and ΔKHN (p<0.001). The highest concentration of CaF2 formed was observed for the FT+Acid gel (p<0.001), followed by FT+9000 gel > FT+TMP gel > FT > PT. CaF2 retained on the blocks was reduced across all groups (p<0.001). Similar values were observed for the Ca/P/F and EPS in enamel and biofilm for all fluoride groups. CONCLUSION: The association of FT+TMP gel significantly reduced enamel demineralization in situ. CLINICAL SIGNIFICANCE: The association of treatments may be an alternative for patients with high caries risk.


Assuntos
Esmalte Dentário/efeitos dos fármacos , Fluoretos Tópicos/farmacologia , Polifosfatos/farmacologia , Desmineralização do Dente/prevenção & controle , Cremes Dentais/farmacologia , Biofilmes/efeitos dos fármacos , Brasil , Cálcio/análise , Fluoreto de Cálcio/farmacologia , Cariostáticos/administração & dosagem , Cariostáticos/química , Cariostáticos/farmacologia , Estudos Cross-Over , Cárie Dentária/prevenção & controle , Relação Dose-Resposta a Droga , Método Duplo-Cego , Combinação de Medicamentos , Fluoretos/análise , Fluoretos Tópicos/administração & dosagem , Fluoretos Tópicos/química , Dureza , Voluntários Saudáveis , Humanos , Concentração de Íons de Hidrogênio , Fosfatos/farmacologia , Polifosfatos/administração & dosagem , Propriedades de Superfície , Cremes Dentais/administração & dosagem , Cremes Dentais/química
16.
Clin Oral Investig ; 22(6): 2241-2249, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29288402

RESUMO

OBJECTIVES: Children in a German region took part in regular toothbrushing with fluoride gel during their time in primary school after having received a preventive program in kindergarten. The study aimed at determining the dental health of the students as a function of prevention in kindergarten and at school while taking into account their socioeconomic status and other confounders. MATERIALS AND METHODS: The subjects were in six groups: groups 1 and 2, intensive prevention in kindergarten with and without fluoride gel at school; groups 3 and 4, basic prevention in kindergarten with and without fluoride gel at school; groups 5 and 6, no organized prevention in kindergarten with and without fluoride gel at school. Two dental examinations were performed for assessing caries experience and calculating caries increment from second grade (7-year-olds) to fourth grade (9-year-olds). A standardized questionnaire was used to record independent variables. To compare caries scores and preventive measures of various subgroups, non-parametric tests and a binary logistic regression analysis were performed. RESULTS: A significant difference was found in the mean decayed, missing, and filled tooth/teeth (DMFT) depending on socioeconomic status (no prevention in kindergarten, fluoride gel at school in children with low SES: DMFT = 0.47 vs. DMFT = 0.18 in children with high SES; p = 0.023). Class-specific differences were no longer visible among children who had taken part in an intensive preventive program combining daily supervised toothbrushing in kindergarten and application of fluoride gel in school. CONCLUSIONS: Early prevention, focusing on professionally supported training of toothbrushing in kindergarten and at school, has a positive effect on dental health and is able to reduce class-specific differences in caries distribution. CLINICAL RELEVANCE: Early training of toothbrushing and fissure sealing of first permanent molars are the most important factors for the dental health of primary school children.


Assuntos
Cariostáticos/administração & dosagem , Fluoretos Tópicos/administração & dosagem , Saúde Bucal , Prevenção Primária , Serviços de Saúde Escolar/organização & administração , Classe Social , Escovação Dentária , Cremes Dentais/administração & dosagem , Criança , Pré-Escolar , Feminino , Alemanha , Humanos , Masculino , Inquéritos e Questionários , Resultado do Tratamento
17.
Acta Odontol Scand ; 76(3): 188-194, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29157063

RESUMO

OBJECTIVE: To evaluate the effect of different fluoride- and calcium- and/or phosphate-containing products on their ability to prevent enamel demineralization under pH cycling conditions. MATERIAL AND METHODS: Enamel bovine specimens were assigned to the following groups: G1-MPP (MI Paste Plus, 0.2% NaF, Recaldent™, GC Corporation Tokyo, Japan); G2-FD (Crest™ Cavity Protection, 0.243% NaF, Procter & Gamble, USA); G3-CLP (Clinpro™ 5000, 1.1% NaF, 3M ESPE, USA); and G4-CO (Control without fluoride, Silica-based dentifrice; Daudt Ltda, Brazil). The specimens were soaked in demineralizing solution for 6 h and remineralizing solution for 18 h alternatively for 10 days. The toothpaste was prepared with deionized water in a 1:3 ratio (w/v) for three minutes daily. The solutions were renewed every 48 h. After cycling, enamel changes were analysed by percentage change of SMH (%SMH) and energy-dispersive X-ray spectroscopy (EDS). The %SMH value observed for G3-CLP (2.9 ± 39.2) was higher than that found in G4-CO (-13.0 ± 20.7), G1-MPP (-8.9 ± 20.9) and G2-FD (-3.9 ± 27.1). The %SMH was similar for all treatment groups (one-way ANOVA and Tukey's HSD; p < .05). The pH, Ca2+ and Ptotal in the remineralization solutions were not different among all groups (Kruskal-Wallis; p < .05). At 24 h, the Ca2+ concentration in the demineralization solution was significantly lower in G1-MPP. Ca2+ concentration increased in all groups after 48 h, except for G3-CLP. The EDX quantitative analysis showed that the atomic % of elements is lower level at G4-CO. CONCLUSIONS: The Clinpro™ 5000 demonstrated having the most protective effect against demineralization; however, the % SMH was similar for all groups.


Assuntos
Caseínas/farmacologia , Esmalte Dentário/efeitos dos fármacos , Fluoretos/farmacologia , Fosfatos/farmacologia , Piperidinas/farmacologia , Cremes Dentais/farmacologia , Animais , Caseínas/administração & dosagem , Bovinos , Cárie Dentária/tratamento farmacológico , Dentifrícios/química , Fluoretos/administração & dosagem , Fosfatos/administração & dosagem , Piperidinas/administração & dosagem , Desmineralização do Dente/prevenção & controle , Remineralização Dentária/métodos , Cremes Dentais/administração & dosagem
18.
Swiss Dent J ; 127(10): 857-864, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29199414

RESUMO

This study analyzed the anti-erosive effect of a self-assembling peptide fibre gel. One hundred and twelve bovine enamel samples were ground flat and subjected to a three times de- and re-mineralization cycle: erosion (5 min, HCl, pH 2.6) alternated with storage in artificial saliva under agitation. Then, samples were covered with different anti-erosive compounds (2 min): Duraphat toothpaste (DT), Elmex Erosion Protection Toothpaste (EET) or Elmex Gelée (EG) ­ all mixed with saliva (1:3) ­, Elmex Erosion Protection Mouthwash (EEM), Curodont Protect (CP; self-assembling peptide gel) or MI Paste Plus (MIP). Untreated, water stored samples served as control. In experiment 1, half of the samples of each group were continuously superfused with HCl (pH 2.6, 60 µl/min, 8 min). In experiment 2, the second half of samples were subjected to eight cycles, each consisting of application of the respective anti-erosive compound followed by an erosion (60 s, HCl, pH 2.6), followed by remineralization in artificial saliva (45 min). Enamel loss was profilometrically determined. In experiment 1, EEM and EET performed significantly better compared to all other compounds. Substance loss of all other compounds did not differ significantly from control. In experiment 2, significantly better performance was achieved by EEM and EET. EG showed significantly lower protection than the control. All other applied compounds yielded no significant difference compared to control. Under the chosen conditions, the self-assembling peptide-containing compound showed no anti-erosive effect.


Assuntos
Cariostáticos/administração & dosagem , Diaminas/administração & dosagem , Fluoretos Tópicos/administração & dosagem , Fluoretos/administração & dosagem , Peptídeos/administração & dosagem , Fluoreto de Sódio/administração & dosagem , Erosão Dentária/terapia , Remineralização Dentária , Animais , Bovinos , Técnicas In Vitro , Antissépticos Bucais/administração & dosagem , Cremes Dentais/administração & dosagem
19.
Stomatologiia (Mosk) ; 96(5): 37-39, 2017.
Artigo em Russo | MEDLINE | ID: mdl-29072644

RESUMO

The aim of the study was to assess gender related salivation features. One hundred and seventy-five patients were enrolled in the study (115 females and 60 males aged from 18 to 75 years). The study results showed xerostomia to be more common in females and it's subjective symptoms are more prominent partly because of gender-related psychological reasons. Xylitol-based paste and spray were successfully used for symptoms relief.


Assuntos
Salivação/fisiologia , Xerostomia/epidemiologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fatores Sexuais , Cremes Dentais/administração & dosagem , Xerostomia/diagnóstico , Xerostomia/terapia , Xilitol , Adulto Jovem
20.
Stomatologiia (Mosk) ; 96(4): 20-22, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28858274

RESUMO

The purpose of this study was to determine the effectiveness of toothpaste Parodontax in patients undergoing orthodontic treatment. The results showed that fixed orthodontic appliances deteriorated oral hygiene, increased the viscosity of saliva and reduced mineralizing capacity of saliva (MCS). Use of Parodontax toothpaste based on sodium bicarbonate improved OHI-S, reduced the viscosity of saliva, increased MCS and normalized oral microbiota.


Assuntos
Boca/microbiologia , Aparelhos Ortodônticos , Ortodontia Preventiva , Saliva/química , Bicarbonato de Sódio/administração & dosagem , Cremes Dentais/administração & dosagem , Adolescente , Feminino , Humanos , Masculino , Microbiota , Higiene Bucal , Calcificação de Dente , Resultado do Tratamento , Viscosidade , Adulto Jovem
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