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1.
S Afr Med J ; 110(3): 197-203, 2020 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-32657696

RESUMO

BACKGROUND: The primary immunodeficiency diseases (PIDs) constitute a diverse and ever-expanding group of inborn errors affecting a wide range of immune functions. They are not well documented in sub-Saharan Africa. OBJECTIVES: To describe the spectrum of PIDs at a tertiary paediatric hospital. METHODS: A retrospective descriptive study of PIDs diagnosed at Red Cross War Memorial Children's Hospital, Cape Town, South Africa (SA), between 1975 and 2017 was undertaken. RESULTS: We identified 252 children with PIDs, spanning eight of the nine categories listed in the 2017 classification of the International Union of Immunological Societies. Predominantly antibody deficiencies, combined immunodeficiencies with associated syndromic features, and immunodeficiencies affecting cellular and humoral immunity accounted for most children with PIDs (n=199, 79.0%). The mean age (standard deviation) at diagnosis was 46 (50) months, and the male/female ratio was 1.5:1. There was a history of parental consanguinity in 3 cases (1.2%). Recurrent infection was the most prevalent presenting phenotype, manifesting in 177 patients (70.2%). Genetic or chromosomal confirmation was obtained in 42/252 cases (16.7%). Common interventions used to prevent infection were antimicrobial prophylaxis and immunoglobulin replacement therapy, administered to 95 (37.7%) and 93 (36.9%) of the patients, respectively. Six of 7 children who underwent haematopoietic stem cell transplantation (HSCT) had successful outcomes. The 7th patient died 2 months after HSCT from overwhelming infection. Although we could not account for the children lost to follow-up during the study period, 53 deaths were confirmed (21.0%). CONCLUSIONS: Several challenges exist in the recognition and treatment of children with PIDs in our setting. These include limited access to genetic diagnostics and HSCT. Suboptimal treatment options contribute to the overall mortality of PIDs in SA.


Assuntos
Doenças da Imunodeficiência Primária/terapia , Adolescente , Criança , Pré-Escolar , Feminino , Hospitais Pediátricos , Humanos , Lactente , Recém-Nascido , Masculino , Doenças da Imunodeficiência Primária/epidemiologia , Doenças da Imunodeficiência Primária/genética , Doenças da Imunodeficiência Primária/mortalidade , Cruz Vermelha , Estudos Retrospectivos , África do Sul/epidemiologia , Fatores de Tempo
2.
Rev. enferm. UERJ ; 27: e39281, jan.-dez. 2019. ilus
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1009801

RESUMO

Objetivo: examinar os estudos desenvolvidos sobre a imagem pública da enfermeira brasileira veiculada em revistas ilustradas das décadas de 1910 e 1920, no Distrito Federal brasileiro. Método: realizada pesquisa documental, mediante análise historiográfica, com ênfase em publicações do início do século XX. Resultados: ratificaram a concorrência da enunciação da imagem pública da enfermeira nas circunstâncias da I Guerra Mundial, da Gripe Espanhola e também da Reforma Sanitária, liderada por Carlos Chagas, por meio dos efeitos simbólicos dos marcadores institucionais representados pelo uso do véu, gorro e touca. A liderança que prevaleceu na enunciação da imagem pública da enfermeira foi a investida pela Escola Prática de Enfermeiras da Cruz Vermelha Brasileira. Conclusão: direciona-se para além da concorrência entre as instituições de ensino, apontando vestígios para disputas em outro campo, o das relações internacionais.


Objective: to examine studies of Brazilian nurses' public image published in illustrated magazines in the 1910s and 1920s in Brazil's Federal District. Method: documentary research was conducted by historiographic analysis, with emphasis on early 20th century publications. Results: the studies ratified the presence of competition in the enunciation of nursing's public image in the circumstances of World War I, the Spanish Flu and also the Sanitary Reform led by Carlos Chagas, through the symbolic effects of institutional markers represented by the use of the veil, nurse's cap and mob-cap. The leadership that prevailed in enunciating nurses' public image was the one invested in by the Brazilian Red Cross Nurses' Practical School. Conclusion: pointing beyond competition among educational institutions, this indicates traces of disputes in another field, international relations.


Objetivo: examinar los estudios desarrollados sobre la imagen pública de la enfermera brasileña vehiculada en revistas ilustradas de las décadas de 1910 y 1920, en el Distrito Federal brasileño. Método: se realizó una investigación documental, mediante análisis historiográfico, con énfasis en publicaciones de principios del siglo XX. Resultados: ratificaron la competencia de la enunciación de la imagen pública de la enfermera en las circunstancias de la 1a Guerra Mundial, de la Gripe Española y también de la Reforma Sanitaria, encabezada por Carlos Chagas, por medio de los efectos simbólicos de los marcadores institucionales representados por el uso del velo y gorro. El liderazgo que prevaleció en la enunciación de la imagen pública de la enfermera fue el de la Escuela Práctica de Enfermeras de la Cruz Roja Brasileña. Conclusión: se dirige más allá de la competencia entre las instituciones de enseñanza, señalando vestigios para disputas en otro campo, el de las relaciones internacionales.


Assuntos
Humanos , Feminino , História do Século XX , Escolas de Enfermagem , Enfermagem , Historiografia , História da Enfermagem , Cruz Vermelha/história , Brasil , Meios de Comunicação de Massa , Enfermeiras e Enfermeiros
4.
J Med Biogr ; 27(4): 220-229, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31483685

RESUMO

At the start of the First World War, the estate of Cliveden was offered as a hospital to the Canadian Government by its owner William Astor. This article describes its history, Sir William Osler's involvement in the hospital, and the involvement of other doctors and some of their research. The rehabilitation programs to help the injured soldiers are described, including the physical, occupational, sporting and social activities undertaken in order to help them towards their return to civilian life. Political ambitions in Canada and friction between the owner of Cliveden, Nancy Astor, and the medical/military establishment led to turmoil which engulfed Osler and is known as the 'Taplow Affair'. The hospital was dismantled after the war but became re-activated in the Second World War and is now a National Trust property.


Assuntos
Hospitais de Convalescentes/história , Médicos/história , Cruz Vermelha/história , Canadá , Inglaterra , História do Século XX , I Guerra Mundial
5.
Gan To Kagaku Ryoho ; 46(5): 907-911, 2019 May.
Artigo em Japonês | MEDLINE | ID: mdl-31189813

RESUMO

Red Cross Pharmaceutical Association conducted a questionnaire-based survey to evaluate the status of implementation of pharmaceutical intervention as well as personal counseling for outpatients with cancer undergoing chemotherapy. Based on the survey results from 93 hospitals across the country, it was found that pharmacists performed an intervention on outpatients receiving chemotherapy in 68 hospitals(73.1%)and conducted personal counseling for outpatients with cancer in 48 hospitals(51.6%). Out of the 68 hospitals, 20 did not conduct personal counseling for outpatients with cancer. This was attributable to the fact that 14 hospitals did not have a qualified pharmacist, 3 did not have sufficient manpower, and 3 did not have the required system. The results of a logistic regression analysis showed that the number of pharmacists significantly affected implementation of pharmaceutical intervention as well as personal counseling for outpatients with cancer undergoing chemotherapy(p=0.042, p=0.023, respectively). The pharmacists can receive a fee for medical services only after conducting personal counseling for outpatients with cancer undergoing chemotherapy. However, in hospitals with a small number of pharmacists, they could not claim their fees owing to lack of manpower. This survey found that lack of manpower is currently the most important issue.


Assuntos
Neoplasias , Cruz Vermelha , Aconselhamento , Humanos , Farmacêuticos , Inquéritos e Questionários
8.
Am J Nurs ; 119(4): 61-62, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30896495

RESUMO

: Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but they also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. To this end, From the AJN Archives highlights articles selected to fit today's topics and times.This month's article appeared in the September 1943 issue, and reported on the spring flooding that had ravaged several midwestern states. Rebecca M. Pond of the Red Cross noted that during the floods, nurses worked in "hutments and barracks in [the] Army airport, unused factory buildings, college buildings, town and rural school houses, Boy Scout camps, abandoned CCC [Civilian Conservation Corps] camps, and an annex to a state hospital." The nursing care provided sounds like nursing in today's disaster shelters: providing health assessments, immunizations, and emergency care; maintaining isolation precautions where needed; monitoring prenatal women, infants, young children, and the elderly or ill; and supervising housekeeping and sanitation services.In recent years, the United States has experienced particularly severe flooding and other disasters precipitated by climate change. In this month's issue, Cara Cook and colleagues explore the many ways in which today's nurses can help to prevent (and not only ameliorate) the effects of a changing climate.


Assuntos
Desastres/história , Inundações/história , Papel do Profissional de Enfermagem/história , Cruz Vermelha , Doenças Transmissíveis , Serviços Médicos de Emergência , História do Século XX , Humanos , Estados Unidos
9.
Disaster Med Public Health Prep ; 13(1): 38-43, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30841950

RESUMO

OBJECTIVES: Two Category 5 storms, Hurricane Irma and Hurricane Maria, hit the U.S. Virgin Islands (USVI) within 13 days of each other in September 2017. These storms caused catastrophic damage across the territory, including widespread loss of power, destruction of homes, and devastation of critical infrastructure. During large scale disasters such as Hurricanes Irma and Maria, public health surveillance is an important tool to track emerging illnesses and injuries, identify at-risk populations, and assess the effectiveness of response efforts. The USVI Department of Health (DoH) partnered with shelter staff volunteers to monitor the health of the sheltered population and help guide response efforts. METHODS: Shelter volunteers collect data on the American Red Cross Aggregate Morbidity Report form that tallies the number of client visits at a shelter's health services every 24 hours. Morbidity data were collected at all 5 shelters on St. Thomas and St. Croix between September and October 2017. This article describes the health surveillance data collected in response to Hurricanes Irma and Maria. RESULTS: Following Hurricanes Irma and Maria, 1130 health-related client visits were reported, accounting for 1655 reasons for the visits (each client may have more than 1 reason for a single visit). Only 1 shelter reported data daily. Over half of visits (51.2%) were for health care management; 17.7% for acute illnesses, which include respiratory conditions, gastrointestinal symptoms, and pain; 14.6% for exacerbation of chronic disease; 9.8% for mental health; and 6.7% for injury. Shelter volunteers treated many clients within the shelters; however, reporting of the disposition (eg, referred to physician, pharmacist) was often missed (78.1%). CONCLUSION: Shelter surveillance is an efficient means of quickly identifying and characterizing health issues and concerns in sheltered populations following disasters, allowing for the development of evidence-based strategies to address identified needs. When incorporated into broader surveillance strategies using multiple data sources, shelter data can enable disaster epidemiologists to paint a more comprehensive picture of community health, thereby planning and responding to health issues both within and outside of shelters. The findings from this report illustrated that managing chronic conditions presented a more notable resource demand than acute injuries and illnesses. Although there remains room for improvement because reporting was inconsistent throughout the response, the capacity of shelter staff to address the health needs of shelter residents and the ability to monitor the health needs in the sheltered population were critical resources for the USVI DoH overwhelmed by the disaster. (Disaster Med Public Health Preparedness. 2019;13:38-43).


Assuntos
Tempestades Ciclônicas/estatística & dados numéricos , Abrigo de Emergência/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Vigilância da População/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Vítimas de Desastres/estatística & dados numéricos , Abrigo de Emergência/organização & administração , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Cruz Vermelha/organização & administração , Ilhas Virgens Americanas/epidemiologia
10.
J Forensic Leg Med ; 61: 75-77, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30471485

RESUMO

Since the mid-1980s, forensic scientists have played a crucial role in the international response to mass violence, contributing evidence to war crimes tribunals and identifying bodies to end the tortuous uncertainty of loved ones. Recently, experts at the International Committee for the Red Cross have described these activities using the term "humanitarian forensic action," applying it from the field's origins in Argentina to the multiple organizations and types of projects that exist today. This article cautions against any account of the history of humanitarian forensic action, or its contemporary landscape, that is so simple and unified. It points to divergent mandates, working methods, and even definitions of humanitarianism, focusing especially on new ways in which forensic scientists are addressing the mass suffering caused by structural violence.


Assuntos
Ciências Forenses/organização & administração , Altruísmo , Humanos , Papel Profissional , Cruz Vermelha
11.
Tob Control ; 28(2): 239-240, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-29695460

RESUMO

'The Holy See cannot be cooperating with a practice that is clearly harming the health of people'. This is the reason behind Pope Francis banning the sale of tobacco products inside the Vatican in January 2018. Just outside the Holy See, in Italy, cigarette sales produce around €13 billion of fiscal revenues every year. In Italy, proposals to increase tobacco taxation are systematically rejected and new tobacco company plants have been officially inaugurated in recent years by representatives of State. The national branch of the Red Cross also shows ambivalent attitudes towards the tobacco industry, from which it has accepted significant funding in disregard of the recommendations of the International Federation of Red Cross. Against this backdrop, it is wishful thinking to imagine that tobacco sales and consumption in Italy will be substantially reduced in the near future. To counteract this situation, more than 30 Italian scientific associations/organisations launched a Manifesto, so far ignored by public authorities, indicating a set of measures whose gradual implementation at country level may lead to a tobacco endgame within the next few decades. Authors of this article would like to express their support for Pope Francis' enlightened decision and plead with politicians worldwide to follow his example, thus acting more decisively against tobacco.


Assuntos
Regulamentação Governamental , Abandono do Hábito de Fumar/legislação & jurisprudência , Produtos do Tabaco/economia , Comércio/estatística & dados numéricos , Humanos , Itália , Cruz Vermelha , Sociedades Científicas , Cidade do Vaticano
12.
Health Promot Int ; 34(3): 429-439, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-29253143

RESUMO

The procurement of blood is an essential challenge of today's health care. Current studies emphasize the influence of word-of-mouth (WOM) on health care behavior, including blood donation. Still, there exists no study which systematically investigates how WOM affects the behavior of blood donors. Therefore, this paper aims to contribute to this lack of research by focusing on Austrian blood donors as possible receivers and senders of WOM. A survey was distributed to 300 donors of the Austrian Red Cross with a return of 245 surveys. The results highlight the strong influence of WOM on the awareness of the blood service and the willingness to donate blood. Further, structured and organized procedures, friendly employees and respectful interaction were found to be important factors determining willingness to recommend blood donation. Family members as well as friends are the preferred WOM-receivers and the personal face-to-face contact is the favored channel of communication. The results also show that WOM-behavior is strongly influenced by factors such as age, gender and donation frequency. By helping blood bank managers to better understand how WOM affects donation intention and behavior, this study provides a new approach to attract blood donors.


Assuntos
Doadores de Sangue/estatística & dados numéricos , Família , Amigos , Comunicação em Saúde , Adulto , Publicidade/estatística & dados numéricos , Áustria , Conscientização , Feminino , Humanos , Intenção , Masculino , Cruz Vermelha , Inquéritos e Questionários
14.
PLoS One ; 13(11): e0207338, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30440009

RESUMO

INTRODUCTION: A number of parenteral infections in third-world countries are caused by blood transfusions. Our objective was to determine the prevalence of and factors associated with infected blood obtained by the Honduran Red Cross through blood donations, to ensure the safety of the donated blood. MATERIALS AND METHODS: This study used a cross-sectional analytical design based on the secondary analysis of data. Information on blood donors from San Pedro Sula, Honduras, between 2014 and 2016 were obtained from the database of the Honduran Red Cross. Data analysis was performed in two phases. The first phase described the variables, with the values presented as frequencies and percentages for categorical variables. The second phase involved a statistical analysis using generalized linear models. RESULTS: The proportions of donors who tested positive for syphilis, core hepatitis, hepatitis B, human T-cell lymphotropic virus, human immunodeficiency virus, and hepatitis C infections were 45% (n = 447), 35% (348), 11% (105), 10% (97), 6% (59), and 3% (24), respectively. The results of multivariate analysis demonstrated that the number of women positive for HIV infection was lower than that of men (p = 0.006). Older participants were more likely to be positive for core hepatitis (p = 0.029) and syphilis (p<0.001) infection but less likely to be positive for hepatitis B (p<0.001), hepatitis C (p = 0.027), human immunodeficiency virus (p<0.001), and human T-cell lymphotropic virus (p<0.001) infection compared to younger participants. Replacement donors had an increased likelihood of positivity for core hepatitis (p = 0.003) infections but a decreased likelihood of positivity for human T-cell lymphotropic virus infection (p = 0.001). DISCUSSION: The high prevalence of infectious diseases in Honduras warrants the need for monitoring donated blood to prevent infected blood from being provided for transfusions. Furthermore, education efforts through the creation of prevention programs are necessary to educate the Honduran population, especially younger individuals, about transfusion-transmissible infections.


Assuntos
Doadores de Sangue , Seleção do Doador , Infecções , Adulto , Estudos Transversais , Feminino , Honduras/epidemiologia , Humanos , Infecções/sangue , Infecções/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Cruz Vermelha
16.
Uisahak ; 27(2): 151-184, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30287722

RESUMO

The Korean Empire, its state sovereignty threatened by the Empire of Japan, joined the Geneva Conventions in 1903 for the purpose of neutral diplomacy and established the imperial Korean Red Cross Hospital in 1905. This hospital was a result of the effort of the Korean Empire to seek a new medical system based on the Western medicine. However, after the Russo-Japanese War, Japan interfered straightforwardly in the domestic affairs of Korea and eventually abolished the Korean Red Cross Hospital in 1907 to create Daehan Hospital under Japanese colonial rule. With newly-found historical records, this study investigates the whole process of the Korean Red Cross Hospital, which has remained unknown so far, despite its importance. From the very beginning, the Korean Red Cross Hospital was under strong influence of the Empire of Japan. The site for the hospital was chosen by a Japanese army doctor, Junryo Yoshimoto, and the construction was supervised by Rokuro Katsumata, who also later on are involved in the construction of Daehan Hospital. Moreover, all the main positions for medical treatments were held by Japanese practitioners such as Goro Tatami and Kaneko Yano. Nevertheless, the Korean government had to shoulder the all operating costs. The office of the Korean Red Cross was relocated away from the Korean Red Cross Hospital, and the government of the Korean Empire was not willing to burden the expenses of the Hospital. Moreover, the list of employees of the Korean Red Cross and that of the Korean Red Cross Hospital were drawn up separately: the former is left only in Korea and the latter in Japan. These facts suggest that those two institutes were managed dualistically unlike any other nation, implying that this may have been a means to support the Daehan Hospital project. According to the statistics, health care services in the Korean Red Cross Hospital seems to have been carried out successfully. There had been an increase in the number of patients, and the ratio of female patients was relatively high (26.4%). Only Western medications were prescribed and surgical operations with anesthesia were performed routinely. The approach to Western medicine in Korea was changing during that period. The rise and fall of the Korean Red Cross Hospital represent the urgent situation of the Korean Empire as well as the imperialistic methodology of the Empire of Japan to use medicine as a tool for colonization. Although the transition process of medical policy by the Japanese Resident-General of Korea still remains to be fully elucidated, this paper contributes to a better understanding of the history of modern medicine in Korea.


Assuntos
Colonialismo/história , Hospitais/história , Cruz Vermelha/história , História do Século XX , Japão , República da Coreia
17.
Transfusion ; 58(12): 2886-2893, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30325043

RESUMO

BACKGROUND: RNA viruses are associated with a high frequency of mutations because of the missing proofreading function of polymerases, such as reverse transcriptase. Between 2007 and 2010, six blood donations with false-negative nucleic acid technology (NAT) results were reported in Germany. Therefore, NAT screening in two viral genome regions was introduced by our blood donation service in 2010 on a voluntary basis and became mandatory in Germany since the beginning of 2015. STUDY DESIGN AND METHODS: Blood donor screening was done using, in parallel, the German Red Cross (GRC) HIV-1 CE long terminate repeats (LTR) PCR kit and the GRC HIV-1 gag CE PCR kit. In total, 7 million blood donations were screened during the study period from 2010 to 2014 with the GRC dual-target human immunodeficiency virus 1 (HIV-1) NAT system. Additionally, three suspicious specimens were analyzed by four monotargeted NAT assays and by five dual-target NAT assays. RESULTS: Three of 7 million donations tested negative using the 5'LTR-polymerase chain reaction, but they were positive if amplification was performed in the gag region. HIV antibodies were detected in all three donations. Nucleic acid sequence analysis identified a deletion of 22 bases within the 5'LTR probe binding region. Three different ltr-based monotargeted assays missed two donations, except for a low-reactive result obtained by one of the assays. In total, the detection rates for HIV-1-positive donations were 37.5% (3/8) for monotargeted assays and 100% (10/10) for dual-target assays. CONCLUSION: The current data demonstrate that dual-target NAT systems reduce the risk of false-negative HIV-1 NAT screening results.


Assuntos
Doadores de Sangue , Repetição Terminal Longa de HIV , HIV-1 , RNA Viral , Kit de Reagentes para Diagnóstico , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Produtos do Gene gag do Vírus da Imunodeficiência Humana , Segurança do Sangue , Seleção do Doador , Feminino , Alemanha , HIV-1/genética , HIV-1/metabolismo , Humanos , Masculino , RNA Viral/sangue , RNA Viral/genética , Cruz Vermelha , Estudos Retrospectivos , Produtos do Gene gag do Vírus da Imunodeficiência Humana/sangue , Produtos do Gene gag do Vírus da Imunodeficiência Humana/genética
18.
Int J Infect Dis ; 77: 40-47, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30244075

RESUMO

OBJECTIVES: This study was performed to investigate the epidemiology of bloodstream infection (BSI) in oncology patients at Red Cross War Memorial Children's Hospital (RCWMCH), Cape Town, with focus placed on the most common causes, complications, and antimicrobial susceptibilities in BSI. METHODS: A retrospective cross-sectional study was conducted in the Haematology-Oncology Unit of RCWMCH. All positive blood cultures from RCWMCH oncology patients obtained in 2012 to 2014 were retrieved to identify cases of BSI. RESULTS: Three hundred and forty-three positive cultures were identified, for 150 BSI episodes among 89 patients; 49.1% of the culture isolates were Gram-positive bacteria, 41.6% were Gram-negative bacteria, and 9.3% were fungal. Coagulase-negative Staphylococcus and viridans group Streptococcus were the most common Gram-positive isolates. Escherichia coli and Klebsiella species were the most common Gram-negative isolates. The majority of BSI episodes occurred in patients with haematological malignancies (74%), in the presence of severe neutropenia (76.4%), and were associated with chemotherapy (88%). Complications occurred in 14% of BSI. Fungal infections had the highest prevalence of complications (21.4%). Three children died during BSI, giving a case-fatality rate of 2%. CONCLUSIONS: BSI in these patients was caused mainly by Gram-positive bacteria and was associated with a low case-fatality rate. These results are consistent with worldwide experience of BSI in paediatric oncology.


Assuntos
Bacteriemia/epidemiologia , Neoplasias/microbiologia , Neutropenia/epidemiologia , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Feminino , Fungos/isolamento & purificação , Bactérias Gram-Negativas/isolamento & purificação , Bactérias Gram-Positivas/isolamento & purificação , Hospitais Pediátricos , Humanos , Masculino , Neoplasias/complicações , Neutropenia/microbiologia , Prevalência , Cruz Vermelha , Estudos Retrospectivos , África do Sul , Resultado do Tratamento
19.
Windows Time ; 26(2): 16-17, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30248254
20.
Transfusion ; 58(10): 2383-2387, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30178874

RESUMO

BACKGROUND: Ammonia in the plasma usually does not pass through the blood-brain barrier (BBB). However, it can affect the brain as a neurotoxin in neonates with anemia of prematurity. Excess intake of ammonia should therefore be restricted in conditions involving BBB breakdown, such as in premature neonates. A potassium adsorption filter (PAF) can remove not only potassium, but also ammonia from red blood cell (RBC) solution. PAF for neonates (PAF-n) has been recently introduced using small satellite packs. We evaluated the effects of PAF-n on the removal of ammonia and potassium from RBC solution in small satellite packs. STUDY DESIGN AND METHODS: RBC solutions were obtained from the Japanese Red Cross Society. Two units of RBC solution (280 mL) were divided into four satellite packs (70 mL/pack). The RBC solution was passed through PAF-n (Kawasumi Laboratories Inc.) that was primed with saline (100 mL) before use. The concentrations of ammonia and potassium were measured in the solution before and after filtration (four samples of 10 mL each of filtered RBC solution) by Biomedical Laboratories. RESULTS: Approximately 47 to 82 and 84% to 93% of ammonia and potassium were removed from the RBC solution, respectively, without dilution with saline. CONCLUSION: PAF-n can remove ammonia and potassium from RBC solution in small satellite packs. PAF-n could therefore improve the clinical prognosis of neonates with poorly developed BBB by limiting the delivery of excess ammonia found in the RBC solution.


Assuntos
Eritrócitos/citologia , Filtração/instrumentação , Adsorção , Amônia/sangue , Amônia/isolamento & purificação , Barreira Hematoencefálica/metabolismo , Humanos , Recém-Nascido , Japão , Potássio/sangue , Potássio/isolamento & purificação , Cruz Vermelha , Soluções/química , Soluções/normas
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