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N Engl J Med ; 382(6): 525-533, 2020 02 06.
Artigo em Inglês | MEDLINE | ID: mdl-32023372


BACKGROUND: We previously reported the results of a trial of prenatal vitamin D supplementation to prevent asthma and recurrent wheeze in young children, which suggested that supplementation provided a protective effect at the age of 3 years. We followed the children through the age of 6 years to determine the course of asthma and recurrent wheeze. METHODS: In this follow-up study, investigators and participants remained unaware of the treatment assignments through the children's sixth birthday. We aimed to determine whether, when maternal levels of 25-hydroxyvitamin D were taken into account, children born to mothers who had received 4400 IU of vitamin D3 per day during pregnancy (vitamin D group) would have a lower incidence of asthma and recurrent wheeze at the age of 6 years than would those born to mothers who had received 400 IU of vitamin D3 per day (control group). Time-to-event methods were used to compare the treatment groups with respect to time to the onset of asthma or recurrent wheeze. Multivariate methods were used to compare longitudinal measures of lung function between the treatment groups. RESULTS: There was no effect of maternal vitamin D supplementation on asthma and recurrent wheeze in either an intention-to-treat analysis or an analysis with stratification according to the maternal 25-hydroxyvitamin D level during pregnancy. There was no effect of prenatal vitamin D supplementation on most of the prespecified secondary outcomes. We found no effects of prenatal supplementation on spirometric indexes. Although there was a very small effect on airway resistance as measured by impulse oscillometry, this finding was of uncertain significance. CONCLUSIONS: Vitamin D supplementation during the prenatal period alone did not influence the 6-year incidence of asthma and recurrent wheeze among children who were at risk for asthma. (Funded by the National Heart, Lung, and Blood Institute; VDAART number, NCT00920621.).

Resistência das Vias Respiratórias/efeitos dos fármacos , Asma/prevenção & controle , Suplementos Nutricionais , Cuidado Pré-Natal , Vitamina D/administração & dosagem , Vitaminas/administração & dosagem , Asma/epidemiologia , Criança , Feminino , Seguimentos , Humanos , Incidência , Análise de Intenção de Tratamento , Pulmão/efeitos dos fármacos , Pulmão/embriologia , Gravidez , Sons Respiratórios/efeitos dos fármacos , Espirometria , Vitamina D/análogos & derivados , Vitamina D/sangue
Medicine (Baltimore) ; 99(6): e18874, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32028397


BACKGROUND: Pregnancy and high impact exercise may cause postnatal urinary incontinence. We aimed to evaluate the life impact of postnatal urinary incontinence in women attending prenatal, high-low impact exercise program, supported by pelvic floor muscle education and training, in comparison to controls. METHODS: It was a quasiexperimental trial among 260 postpartum Caucasian women (age 29 ±â€Š4 years; mean ±â€Šstandard deviation). The training group (n = 133) attended a high-low impact exercise and educational program from the 2nd trimester of pregnancy until birth, 3 times a week. We educated this group to contract and relax pelvic floor muscles with surface electromyography biofeedback and instructed how to exercise postpartum. Control women (n = 127) did not get any intervention. All women reported on the life impact of urinary incontinence 2 months and 1 year postpartum using the Incontinence Impact Questionnaire (IIQ). RESULTS: Training group started regular pelvic floor muscle exercises substantially earlier postpartum than controls (P < .001). Significantly less training women reported the life impact of urinary incontinence both 2 months (P = .03) and 1 year postpartum (P = .005). Two months after birth, for the symptomatic women the IIQ scores were significantly lower in the training than in the control women (median [Me] = 9.4 vs Me = 18.9; P = .002). Between the 1st and 2nd assessments the number of women affected by incontinence symptoms decreased by 38% in the training group and by 20% in the controls. CONCLUSION: High-low impact activities supported by pelvic floor muscle exercises and education should be promoted among pregnant, physically active women. Such activities may help women to continue high-intensity exercise with the simultaneous prevention of postnatal urinary incontinence.Thy study was registered at ISRCTN under the title "Pelvic floor muscle training with surface electromyography" (DOI 10.1186/ISRCTN92265528).

Terapia por Exercício , Diafragma da Pelve , Cuidado Pré-Natal , Transtornos Puerperais/prevenção & controle , Incontinência Urinária/prevenção & controle , Adulto , Feminino , Humanos , Gravidez , Qualidade de Vida , Inquéritos e Questionários , Resultado do Tratamento
Mymensingh Med J ; 29(1): 60-65, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31915337


In spite of the recommendation for rescue antenatal corticosteroids (ACS), the optimal time interval between primary and rescue courses has not been clearly demonstrated. The aim of this retrospective study was to determine the effects of the interval between a single ACS (Dexamethasone) course and delivery on the incidence of respiratory distress syndrome (RDS) in neonates at Mymensingh Medical College Hospital Center from 1st January 2017 to 30th June 2017. Injection Dexamethasone 2 doses (12.5mg IM 12 hourly for 2 doses) or 4 doses (6mg IM every 12 hours for 4 doses) use to arrest preterm labor as well as to prevent RDS delivered beyond 48 hours after ACS administration between 24 and 34 weeks gestation. The risk of RDS was compared between patients who delivered within seven days (Group I) and 7-14 days (Group II) after ACS administration. We included 140 and 60 patients in Group I and Group II respectively. After adjusting for confounders, the ACS delivery interval was significantly associated with RDS in Group II (adjusted odds ratio 12.8, 95% confidence interval 1.31-164.7). A longer ACS delivery interval is associated with a higher risk of RDS. Thus, the use of a rescue course could be expected to reduce the incidence of RDS in patients beyond seven days after ACS administration who remain at risk for preterm delivery within seven days, especially in cases of placenta previa and/or women bearing a male fetus.

Corticosteroides/administração & dosagem , Dexametasona/administração & dosagem , Nascimento Prematuro/prevenção & controle , Cuidado Pré-Natal/métodos , Síndrome do Desconforto Respiratório do Recém-Nascido/epidemiologia , Corticosteroides/efeitos adversos , Bangladesh/epidemiologia , Dexametasona/efeitos adversos , Feminino , Humanos , Incidência , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Gravidez , Síndrome do Desconforto Respiratório do Recém-Nascido/prevenção & controle , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento
Medicine (Baltimore) ; 99(1): e18447, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31895773


Prenatal examination is a pivotal measure to prevent high-risk pregnancy and to ensure the safety of both mother and infant. However, pregnant women in Linzhi Prefecture in the Tibet Autonomous Region (TAR) often cannot obtain regular prenatal examinations due to limited accessibility of healthcare facilities, shortage of medical staff, and lack of medical equipment. Health education is an important approach to solve this ever-growing issue of pregnant women in rural Tibet.To evaluate the efficacy of flexible methods of health education programs on improving compliance among pregnant women from Tibet, China.In May to November of 2018, a total of 168 pregnant women receiving prenatal examination in a tertiary referral hospital in Linzhi Prefecture were recruited and randomly assigned to a control (n = 85) and intervention group (n = 83). All pregnant women were followed up until delivery. The pregnant women in the control group received regular prenatal examination and health education programs. Other than receiving routine prenatal care, participants of the interventional group also voluntarily joined the WeChat Social Messaging platform. Online resources posted by the maternity schools provided convenience and flexibility for the pregnant woman. The number of prenatal examinations was statistically significant between the 2 groups. The effect of flexible patterns of health education programs on improving the compliance of pregnant women in Tibet was assessed.The number of prenatal examinations in the intervention group was 2.646 times, which was higher than that in the control group (P < .01). Multivariate analysis demonstrated that interventional measures and ethnicity were the influencing factors of the number of prenatal examinations for pregnant women in Linzhi after the adjustment of age, history of adverse pregnancy, education level, ethnicity, multiparity, gestational complications, and medical history. The number of prenatal examinations for the pregnant Tibetan women was 0.535 times lower compared with that of the pregnant Han women (95% CI: -0.089, 1.157, P = .091).Flexible forms of health education during the antenatal period can effectively increase the compliance of pregnant women in Tibet.

Educação em Saúde/métodos , Cooperação do Paciente , Cuidado Pré-Natal/estatística & dados numéricos , Adulto , Feminino , Humanos , Gravidez , Rede Social , Tibet
Arch Dis Child Fetal Neonatal Ed ; 105(1): 50-55, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31123055


OBJECTIVE: Higher rates of neonatal morbidity and mortality at term combined with earlier spontaneous delivery have led to the hypothesis that babies born to South Asian born (SA-born) women may mature earlier and/or their placental function decreases earlier than babies born to Australian and New Zealand born (Aus/NZ-born) women. Whether babies born to SA-born women do better in the preterm period, however, has yet to be evaluated. In this study we investigated respiratory outcomes, indicative of functional maturity, of preterm babies born to SA-born women compared with those of Aus/NZ-born women to explore this hypothesis further. STUDY DESIGN AND SETTING: This retrospective cohort study was conducted at Monash Health. PATIENTS: Data were collected from neonatal and birth records of moderate-late preterm (32-36 weeks) infants born between 2012 and 2015 to SA-born and Aus/NZ-born women. OUTCOME MEASURES: Rates of nursery admissions and neonatal respiratory outcomes were compared. RESULTS: Babies born to Aus/NZ-born women were more likely to be admitted to a nursery (80%) compared with SA-born babies (72%, p=0.004). Babies born to SA-born mothers experienced significantly less hyaline membrane disease (7.8%), required less resuscitation at birth (28.6%) and were less likely to require ventilation (20%) than babies born to Aus/NZ-born mothers (18%, 42.2%, 34.6%; p<0.001). There was no difference in the duration of ventilation or length of stay in hospital. CONCLUSIONS: Moderate-late preterm babies born to SA-born women appear to have earlier functional maturity, as indicated by respiratory outcomes, than Aus/NZ-born babies. Our findings support the hypothesis of earlier fetal maturation in SA-born women.

Grupo com Ancestrais do Continente Asiático , Grupo com Ancestrais do Continente Europeu , Doença da Membrana Hialina/epidemiologia , Nascimento Prematuro , Ressuscitação/estatística & dados numéricos , Adulto , Ásia Sudeste/etnologia , Austrália , Peso ao Nascer , Índice de Massa Corporal , Estudos de Coortes , Feminino , Glucocorticoides/uso terapêutico , Humanos , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Mães , Nova Zelândia , Admissão do Paciente/estatística & dados numéricos , Cuidado Pré-Natal , Respiração Artificial/estatística & dados numéricos , Estudos Retrospectivos
Expert Rev Clin Pharmacol ; 13(1): 65-73, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31791157


Introduction: Neonatal sepsis (NS) is a very severe condition that causes significant morbidity and mortality.Areas covered: To overcome the limits of antibiotic therapy and improve NS outcomes, measures chosen among those theoretically able to improve host defenses or positively interfere with deleterious immune responses could be suggested. This paper discusses the mechanisms of action of these measures, whether their efficacy in prophylaxis justifies use in NS therapy and their impact.Expert opinion: NS remains a relevant problem despite the availability of antibiotics effective against the most common agents and the introduction of effective preventive measures such as group B Streptococcus prenatal screening and intrapartum antibiotic prophylaxis. This explains why attempts to introduce new prophylactic and therapeutic measures have been made. Unfortunately, none of the measures suggested and tested to date can be considered a definitive advance. It is highly likely that in the future, new measures will be proposed according to the increase in the knowledge of the characteristics of immune system function in preterm infants and the methods to modulate unproper immune responses.

Antibacterianos/administração & dosagem , Sepse Neonatal/tratamento farmacológico , Cuidado Pré-Natal/métodos , Antibioticoprofilaxia/métodos , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Sepse Neonatal/prevenção & controle , Gravidez
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 281-287, jan.-dez. 2020. tab
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-1047844


Objetivo: investigar os fatores maternos e perinatais associados aos extremos da idade reprodutiva da mulher em São Luís, Maranhão. Método: trata-se de um estudo transversal, realizado em São Luís/MA, com população de 16.474 mães. Os dados foram coletados no Sinasc disponibilizado pela Secretaria Municipal. Utilizou-se o Teste Qui-quadrado de Pearson e calculou-se a Odds Ratio com nível de significância de α = 0.05. Resultados: verificou-se que as adolescentes apresentaram maior chance de nascimentos prematuros (OR=1,37; p< 0,001 mulheres com idade avançada apresentaram maior risco para baixo peso ao nascer (OR=1,22; p=0,022). Tanto as adolescentes (OR=2,09; p< 0,001) quanto as mães com idade avançada (OR=1,85; p<0,0011) possuem chances aumentadas para realizarem menos que seis consultas de pré-natal. Conclusão: os resultados perinatais, nascimento prematuro, baixo peso ao nascer e a realização de menos de seis consultas pré-natais são elevados nas gestações de adolescentes e mulheres em idade avançada

Objective: to investigate maternal and perinatal factors associated with extremes of women's reproductive age in São Luís, Maranhão. Method: this is a cross-sectional study conducted in São Luís/MA, with a population of 16,474 mothers. The data were collected in the Sinasc provided by the Municipal Health Secretariat. We used the Pearson Chi-square test and calculated the odds ratio with a significance level of α=0.05. Results: it was verified that the adolescents had a higher chance of preterm birth (OR=1.37; p<0,001); Women aged 35 years or older were at increased risk for low birth weight (OR=1.22; p=0.022). Both adolescents (OR=2.09; p<0,001) and older mothers (OR=1.85; p<0,001) have an increased chance to perform less than six prenatal visits. Conclusion: perinatal outcomes, preterm birth, low birth weight and fewer than six prenatal visits are frequent in the pregnancies of adolescents and women of advanced age

Humanos , Feminino , Gravidez , Adulto , Pessoa de Meia-Idade , Complicações na Gravidez/epidemiologia , Cuidado Pré-Natal , Idade Materna , Saúde Materno-Infantil , Fatores de Risco , Gravidez de Alto Risco , Assistência Perinatal
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-1048327


Objetivo: descrever ações executadas pelo acompanhante junto à parturiente, conforme informações recebidas no pré-natal. Método: estudo qualitativo, descritivo, exploratório, com 21 acompanhantes, com o uso de um questionário semiestruturado. No processamento de análise dos dados, foi utilizado o software Iramuteq. Resultados: emergiram duas classes: 1. A informação no pré-natal sobre o direito do acompanhante e 2. A participação do acompanhante junto à parturiente e as ações executadas. Conclusão: a informação referente ao direito do acompanhante e ações a serem desenvolvidas por eles no processo de parto foram poucas ou nenhuma durante o pré-natal e as ações realizadas por eles foram provenientes de conhecimento adquirido por meio de busca individual ou recebido no momento da internação

Objective: to describe actions taken by the companion of the parturient, according the information received in prenatal care. Method: qualitative, descriptive, exploratory study with 21 companions, with the use of a semi-structured questionnaire. In the data analysis processing, Iramuteq software was used. Results: the two categories that emerged: 1. The information in the prenatal about your rights to the parturient companion 2. The participation of the parturient companion and the actions taken. Conclusion: observed that the information concerning the right of the companion and actions to be undertaken by them on labor process, were little or no during prenatal care, and the actions performed by them came from knowledge acquired through individual search or received at the time of hospitalization

Objetivo: describir acciones ejecutadas por el acompañante junto a la parturienta, conforme informaciones recibidas en el prenatal. Método: estudio cualitativo, descriptivo, exploratorio, con 21 acompañantes, con el uso de un cuestionario semiestructurado. En el procesamiento de análisis de los datos, se utilizó el software Iramuteq. Resultados: emergieron dos clases: 1. La información en el prenatal sobre el derecho del acompañante y 2. La participación del acompañante junto a la parturienta y las acciones ejecutadas. Conclusión: la información referente al derecho del acompañante y acciones a ser desarrolladas por ellos en el proceso de parto y parto fueron pocas o ninguna durante el prenatal y las acciones realizadas por ellos, fueron provenientes de conocimiento adquiridos por medio de búsqueda individual o recibidas en el momento de la internación

Humanos , Masculino , Feminino , Gravidez , Adulto , Pessoa de Meia-Idade , Cuidado Pré-Natal , Parto Humanizado , Acompanhantes Formais em Exames Físicos/tendências , Relações Profissional-Família , Relações Profissional-Paciente , Trabalho de Parto , Parto , Pesquisa Qualitativa , Humanização da Assistência , Acolhimento
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-1048100


Objetivo: conhecer a visão dos enfermeiros/as e médicos/as sobre a paternidade na adolescência; identificar ações direcionadas ao jovem pai no pré-natal. Método: pesquisa documental com abordagem qualitativa, com dados produzidos pelo projeto "Saúde sexual e reprodutiva como direito de mulheres e homens na atenção à saúde". Os documentos/entrevistas com profissionais que realizam consultas de pré-natal nas ESF possibilitaram a análise de conteúdo nas categorias: "Visão dos profissionais sobre paternidade na adolescência" e "Ações no pré-natal voltadas aos jovens pais". Resultados: as participantes declararam a diferença entre ser pai jovem e adulto, destacando-se a maturidade. A maioria condenou a gravidez na adolescência, e a não-frequência dos pais às consultas. Conclusão: ser pai, em qualquer idade, não afasta as relações tradicionais de gênero, sendo sua inclusão insuficiente. Interpretar negativamente a paternidade na adolescência contribui no afastamento desse jovem pai aos serviços de saúde

Objective: recognize nurses' and doctors' overview on adolescent fatherhood; Identify which actions are guided to a young father during prenatal care. Method: documental research with a qualitative approach, with data produced by the project "Sexual and reproductive health as women and men's right in health care." The documents/interviews from the professionals who consult prenatal in ESF enabled the analysis of the content in categories: "Professionals' overview on adolescent paternity" and "Actions during prenatal period on young fathers." Results: the participants stated the difference between being a young or adult father with emphasis in their maturity. Most of them bashed teenage pregnancy and also fathers' absences in consultations. Conclusion: being a father does not bring traditional gender relations out at any age, but his inclusion is unsatisfactory. A negative interpretation on adolescent paternity contributes to young father's distancing to health care services

Objetivo: conocer puntos de vista de enfermeros/as y médicos/as sobre paternidad adolescente; identificar acciones dirigidas al joven padre durante prenatal. Método: Investigación documental con enfoque cualitativo, cuyos datos son producidos por el proyecto "Salud sexual y reproductiva como derecho de mujeres y hombres en atención de salud." Documentos/entrevistas con profesionales realizando consultas de prenatal en ESF posibilitaron análisis de contenido en estas categorías: "Puntos de vista de profesionales sobre paternidad adolescente" y "Acciones en prenatal volcadas hacia jóvenes padres". Resultados: participantes declararon haber diferencia entre ser padre joven y adulto, destacando la madurez. La mayoría condenó el embarazo adolescente, y la no-asistencia de los padres a las consultas. Conclusión: ser padre, a cualquier edad, mantiene las relaciones tradicionales de género por tanto su inclusión es insuficiente. Interpretar negativamente la paternidad adolescente contribuye al alejamiento del joven padre de servicios de salud

Humanos , Masculino , Feminino , Gravidez , Adolescente , Paternidade , Gravidez na Adolescência , Cuidado Pré-Natal , Brasil , Pessoal de Saúde
Ceska Gynekol ; 84(5): 361-370, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31826634


DESIGN: Review article. SETTING: Department of Clinical Biochemistry, University Hospital Olomouc; Department of Obstetrics and Gynecology, Palacky University Olomouc, Faculty of Medicine and Dentistry, University Hospital Olomouc; The Institute for the Care of Mother and Child and 3rd Faculty of Medicine Charles University, Prague; G-CENTRUM Olomouc, Olomouc; Genetika Plzeň, Pilsen. Methods, results: Preeclampsia (PE) is a multisystem disorder complicating pregnancy. It is the leading cause of maternal and perinatal mortality and morbidity worldwide. Recent studies have shown that high-risk pregnant women may benefit from low-dose acetylsalicylic acid early therapy in prevention of the development of severe forms of the disease. The risk group of pregnant women should be identified in 11-13 gestational week for effective prevention. The only procedure validated in many studies for performing PE screening with sufficient diagnostic accuracy in the first trimester of pregnancy is given by The Fetal Medicine Foundation (FMF) and has been adopted and published in a new recommendation by The International Federation of Gynecology and Obstetrics (FIGO). CONCLUSION: This article summarizes the recent findings and recommendation for performing screening of preeclampsia in 1st trimester of pregnancy and how to prevent the development of severe forms of PE by low-dose acetylsalicylic acid therapy.

Aspirina/administração & dosagem , Programas de Rastreamento/métodos , Pré-Eclâmpsia/diagnóstico , Pré-Eclâmpsia/prevenção & controle , Biomarcadores/sangue , Feminino , Humanos , Pré-Eclâmpsia/sangue , Gravidez , Primeiro Trimestre da Gravidez , Cuidado Pré-Natal , Fatores de Risco
Niger J Clin Pract ; 22(12): 1635-1643, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31793468


Background: Prenatal distress and fear of childbirth negatively affect the health of the mother and the fetus. Sociodemographic and pregnancy related characteristics may influence prenatal distress and fear of childbirth. Aim: This study aimed to explore the relationship between fear of childbirth and prenatal distress levels with accompanying factors. Subjects and Methods: The study was designed as a cross-sectional survey study and conducted in the outpatient clinic of Obstetrics and Gynecology Department of Pamukkale University Hospital, Denizli, Turkey, between April 2017 and January 2018. Survey data were collected from 103 third-trimester pregnant women who had admitted to the hospital for routine prenatal examination. Sociodemographic Information Form, the Revised Prenatal Distress Questionnaire (NUPDQ), and the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) were used to collect data. Sociodemographics, obstetrics, and other variables were summarized by descriptive statistics. Mann-Whitney U-test, Chi-squared test, and Fisher's exact test were used for comparison of data between groups. Results: The mean score of NUPDQ was 7.58 (SD 4.09) in the nulliparous group and 8.17 (SD 5.16) in the multiparous group (P = 0.68). The mean W-DEQ score was 40.46 (SD 21.80) in nulliparous women and 45.55 (SD 26.72) in multiparous women (P = 0.38). The W-DEQ and NUPDQ scores were moderately correlated with a Spearman correlation co-efficient of 0.58 (P < 0.001). Conclusions: The results of this study revealed that fear of childbirth and prenatal distress were moderately and positively correlated. NUPDQ and W-DEQ can be used during pregnancy to understand if pregnant women have fear or distress. This could help to give a better support to pregnant women.

Ansiedade/psicologia , Parto Obstétrico/psicologia , Medo/psicologia , Parto/psicologia , Gestantes/psicologia , Adulto , Estudos Transversais , Feminino , Humanos , Paridade , Gravidez , Cuidado Pré-Natal , Estresse Psicológico , Inquéritos e Questionários , Turquia , Adulto Jovem
Pan Afr Med J ; 34: 46, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31803342


Introduction: Every day, approximately 830 women globally die from pregnancy-child birth related complications and all maternal deaths are mainly due to the three phases of delay usually experienced in maternal care which originates from inadequate or lack of birth and emergency preparedness. Despite the benefit of Birth Preparedness and Complications Readiness (BPACR) in the reduction of the three phases of delay and thus reduction of maternal deaths and complications, no study has been conducted in Adjumani district to assess the knowledge and practice of birth preparedness and complication readiness, thus our objective was to assess the knowledge and practice of Birth Preparedness and Complications Readiness (BPACR) among pregnant women attending antenatal clinic at Openzinzi Health Centre (HC) III in Adjumani District. Methods: A descriptive cross sectional study design with a sample of 80 respondents was used for the study. Simple random sampling was used to select the respondents in the study area. A research administered questionnaire was used for data collection. Results: Most of the respondents (27.5%) were in the age group of 26-35 years. The majority 43.75% ended at primary level of education, 50% were unemployed, and the majority 71.25% and 70% knew identifying skilled birth attendants and health facilities respectively as components of BPACR. 76.25% of the respondents mentioned vaginal bleeding and 62.5% over vomiting as danger signs in pregnancy while 12.5% did not know any danger sign in pregnancy. 76.25% identified place for skilled birth, 66.25% identified skilled birth attendant, and only 15% identified blood donor. Conclusion: The practice of BPACR was poor among the pregnant women attending antenatal care at Openzinzi Health Centre III in Adjumani District. The knowledge about BPACR was higher among the educated respondents involved in the study.

Parto Obstétrico/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Complicações na Gravidez/prevenção & controle , Cuidado Pré-Natal/métodos , Adolescente , Adulto , Estudos Transversais , Escolaridade , Feminino , Humanos , Morte Materna/prevenção & controle , Pessoa de Meia-Idade , Gravidez , Inquéritos e Questionários , Uganda , Adulto Jovem
Pan Afr Med J ; 34: 68, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31819784


Introduction: More than 20 million infants were born with low birth weight in worldwide. Low birth weight contributes more than 80 percent of all the neonatal mortality. In Ethiopia, studies have shown that there is a high prevalence of low birth weight among newborns. Thus, this study was aimed to determine the magnitude and associated factors with low birth weight among newborns delivered at term in Kambata-Tembaro zone, Southern Ethiopia, 2018. Methods: Institution based cross-sectional study design was used. The sample size was proportionally allocated to each hospital. The total of 341 study participants was enrolled using systematic random sampling techniques. Data were collected by interview-administered questionnaire and entered using Epi-Info version-7 and exported to SPSS version 20 for analysis. Multivariate logistic regression analysis was carried out to identify associated factors with the low birth weight. Results: The prevalence of low birth weight was 18% and significantly associated with the mothers' non-employment [aOR=5.4;95%CI:1.7-17.4], residing in the rural [AOR=5.4; 95%CI:2.1-14.7], unintended pregnancy [aOR=2.0;95%CI:1.2-3.8], not attending antenatal care [aOR=2.3;95%CI: 1.3-2.7], mothers with greater than three births [aOR=1.5;95% CI:1.8-2.6], birth interval less than or equal to two years [aOR=1.9;95%CI:1.6-3.6] and intimate partner violence during pregnancy [aOR=2.1:95% CI: 1.1-3.9]. Conclusion: The study finding shown that the prevalence of low birth weight among newborn was high (18%) in the study. Preventing of low birth weight is an important intervention to reduce neonatal death. Therefore, maximizing women economic status, providing quality family planning services, enabling pregnant women to use antenatal care and preventing intimate partner violence during pregnancy via launching women empowering strategies in the community level is highly recommend.

Serviços de Planejamento Familiar/estatística & dados numéricos , Recém-Nascido de Baixo Peso , Violência por Parceiro Íntimo/estatística & dados numéricos , Cuidado Pré-Natal/estatística & dados numéricos , Adolescente , Adulto , Estudos Transversais , Etiópia/epidemiologia , Feminino , Hospitais/estatística & dados numéricos , Humanos , Recém-Nascido , Gravidez , Prevalência , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários , Adulto Jovem
RECIIS (Online) ; 13(4): 843-853, out.-dez. 2019. ilus
Artigo em Português | LILACS | ID: biblio-1047584


Os indicadores de morbidade e de mortalidade materno-infantis são essenciais no contexto da organização da Rede Cegonha, no âmbito do Sistema Único de Saúde (SUS). Esta rede organiza-se para assegurar o acesso, o acolhimento e a resolutividade, por meio de um modelo de atenção voltado para o pré-natal, parto e nascimento, puerpério e sistema logístico. Este artigo apresenta um estudo ecológico desta rede em uma Regional de Saúde, realizado com uso de dados dos Sistemas de Informação de Saúde do Departamento de Informática do SUS. Verificou-se um percentual crescente de gestantes que realizaram sete ou mais consultas pré-natais. No entanto, poucas concluíram a assistência pré-natal, porque não realizaram a consulta de puerpério. Observou-se uma taxa de mortalidade infantil próxima à da meta estipulada pela ONU. Identificou-se um aumento das cesáreas e uma redução de partos normais, além de uma alta mortalidade materna. Esses indicadores apontam para a necessidade de melhoria da qualidade da atenção pré-natal e da assistência ao parto.

Indicators of maternal-child morbidity and mortality are essential in the context of the organization of the Rede Cegonha (Stork Network), within the scope of the Unified Health System (SUS ­ Sistema Único de Saúde). This network is organized to ensure access, protection and successful resolution, through a model of attention focused on prenatal, delivery and childbirth, puerperium (or postpartum period) and logistic system. This article presents an ecological study of this network in a Regional de Saúde (Regional Health Department) that was carried out using data from the SUS Department of Informatics of the Health Information Systems. An increasing percentage of pregnant women who had seven or more prenatal visitscould be observed. However, few pregnant women completed prenatal care because they have not sought for the puerperium consultation. A child mortality rate close to the target set out in the United Nations Sustainable Development Goals was observed. An increase in caesarean sections and a reduction in normal deliveries and at the same time a high maternal mortality were identified. These indicators point to the need to improve the quality of prenatal and delivery care.

Los indicadores de morbilidad y de mortalidad materno-infantil son esenciales en el contexto de la organización de la Rede Cegonha (Red Cigüeña), en el ámbito del Sistema Único de Salud (SUS ­ Sistema Único de Saúde). Esa red se organiza para asegurar el acceso, el acogimiento y la capacidad resolutiva, por medio de un modelo de atención dirigido al prenatal, parto, nacimiento, puerperio y sistema logístico. Este artículo presenta un estudio ecológico de la red en una Regional de Saúde (Dirección Regional de Salud) realizado utilizando datos de los Sistemas de Información de Salud del Departamento de Informática del SUS. Se ha verificado un porcentaje creciente de gestantes que realizaron siete o más consultas de prenatal. Sin embargo, pocas gestantes concluyeron la asistencia prenatal, porque no realizaron la consulta de puerperio. Se observó una tasa de mortalidad infantil próxima a la meta estipulada por la ONU. Se identificó un aumento de las cesáreas y una reducción de partos normales, además de una alta mortalidad materna. Esos indicadores apuntan la necesidad de mejorar la calidad de la atención prenatal y de la asistencia al parto.

Humanos , Mortalidade Infantil , Mortalidade Materna , Indicadores Básicos de Saúde , Saúde da Mulher , Assistência à Saúde , Cuidado Pré-Natal , Sistema Único de Saúde , Saúde da Criança , Parto Humanizado , Serviços de Saúde Materno-Infantil , Estudos Ecológicos , Acolhimento , Acesso aos Serviços de Saúde
RECIIS (Online) ; 13(4): 863-876, out.-dez. 2019. ilus, tab
Artigo em Português | LILACS | ID: biblio-1047592


Este artigo se baseia em um estudo de série temporal sobre os óbitos fetais por malformações congênitas no estado do Maranhão relativo ao período de 2006 a 2016. Foram construídos indicadores epidemiológicos para estimar o risco de morte fetal e sua tendência ao longo da série estudada. Os dados são provenientes do Departamento de Informática do SUS e sua análise realizada por modelos de regressão linear. Foram registrados 17.843 óbitos fetais no período abordado pelo estudo, 528 dos quais decorrentes de malformações congênitas (2,96%). Observou-se uma tendência significativa de aumento do coeficiente de mortalidade fetal geral, correspondente a 6,99% (ß1=0,17; p=0,004) e do específico por malformações congênitas, equivalente a 5,13% (ß1=0,01; p=0,04). Os resultados deste estudo corroboram a tendência histórica dos serviços de saúde negligenciarem os óbitos fetais. É importante destacar que parte destes óbitos são preveníveis e potencialmente evitáveis. Desse modo, a implementação dos comitês de investigação de óbitos fetais e infantis e a sua vigilância adequada poderiam melhorar a assistência prestada tanto no pré-natal quanto no parto.

This article bases on a time series study about fetal deaths due to congenital malformations in the state of Maranhão, Brazil, occurred from 2006 to 2016. Epidemiological indicators were constructed to estimate the risk of fetal death and its trend throughout the series studied. The data were obtained in the Department of Informatics of SUS and analyzed by linear regression models. There were 17,843 fetal deaths during the analysed period, from which 528 were a direct result of congenital malformations (2.96%). A significant tendency towards an increase in the coefficient of general fetal mortality corresponding to 6.99% (ß1=0.17; p=0.004) and in the coefficient of specific fetal mortality due to congenital malformations equivalent to 5.13% (ß1=0.01; p=0.04) were observed. The end results of this study corroborate the historical trend toward negligence in Brazilian health centres with regard to fetal deaths. It is important to remark that some of these deaths can be presumed and potentially preventable. Thus, the implementation of the fetal and infant death investigation committees and their adequate surveillance could improve care during prenatal and delivery.

Este artículo se basa en un estudio de serie temporal acerca de muertes de fetos por malformaciones congénitas en el estado de Maranhão, Brasil, concerniente al periodo de 2006 a 2016. Se construyeron indicadores epidemiológicos para estimar el riesgo de la muerte fetal y su tendencia a lo largo de la serie estudiada. Los datos son provenientes del Departamento de Informática del SUS y fueron analizados por modelos de regresión lineal. Se registraron 17.843 muertes de fetos en el período estudiado, de los cuales 528 fueron resultado de malformaciones congénitas (2,96%). Se observó una tendencia significativa al aumento del coeficiente de mortalidad fetal general correspondiente a 6.99% (ß1=0,17; p=0,004) y del específico, por malformaciones congénitas, equivalente a 5,13% (ß1=0,01; p=0,04). Los resultados del estudio corroboran la tendencia histórica a la negligencia de los centros de salud brasileños con respecto a las muertes de los fetos. Por su importancia debemos destacar que parte de esas muertes son presumibles y pueden ser evitadas. De ese modo, la implementación de los comités de investigación de muertes de fetos y infantiles y su vigilancia adecuada podrían mejorar la asistencia prestada en el prenatal y en el parto.

Humanos , Anormalidades Congênitas , Sistemas de Informação , Epidemiologia , Mortalidade Fetal/tendências , Estudos Ecológicos , Morte Fetal/etiologia , Cuidado Pré-Natal , Saúde Materno-Infantil , Mortalidade , Indicadores de Desenvolvimento
Mem. Inst. Invest. Cienc. Salud (Impr.) ; 17(3): 10-19, dic.2019. tab, ilus
Artigo em Espanhol | LILACS, BDNPAR | ID: biblio-1047708


En Paraguay se estima que 165.000 personas están infectadas por Trypanosoma cruzi, agente etiológico de la enfermedad de Chagas, de las cuales 61.000 son mujeres en edad fértil. En 1995 se implementó el Programa de Control Prenatal de Chagas en el departamento de Cordillera, zona endémica del país. El objetivo de este estudio es analizar el comportamiento de la seropositividad a T. cruzi en embarazadas en 21 años de control prenatal (período: 1995-2016), con énfasis en el periodo 2010-2016. El estudio, descriptivo de corte trasversal retrospectivo, empleó los datos obtenidos de los registros de la III Región Sanitaria y de los cinco laboratorios de diagnóstico. Se emplearon los resultados de la serología de 20 distritos en un total de 23.661 embarazadas que asistieron a su control prenatal. En los registros figuran 1.074 embarazadas seropositivas, distribuidas en los cinco laboratorios de referencia, resultando el 5 % la prevalencia de infección con T. cruzi en el período 2010-2016. Con una prevalencia al inicio del período de 16 %, se evidenció el principal descenso a 6 % en el 2014, situación que se mantuvo en una fase cuasi estacionaria hasta el 2016. Se concluye que el sistema de diagnóstico prenatal de la enfermedad de Chagas asociado a los métodos de prevención implementados por el Ministerio de Salud Pública y Bienestar Social, han resultado efectivos. Esta información es útil para, a través de la identificación de las embarazadas seropositivas y el tratamiento correspondiente, controlar la transmisión congénita(AU)

It is estimated that in Paraguay 165,000 people are infected with Trypanosoma cruzi, the etiological agent of Chagas disease. Among them 61,000 are women of childbearing age. In 1995, it was implemented the Chagas Prenatal Control Program in the Cordillera department, one of the endemic areas of the country. Herein is analyzed the evolution of T. cruzi seropositivity in pregnant women in the 21 years of prenatal control (period: 1995-2016), with emphasis on the period 2010-2016. In this descriptive study, data from the registers of the III Sanitary Region and from the five diagnostic laboratories were used. The serologic results of 20 districts involved 23,661 pregnant women who attended their prenatal control. It was recorded 1,074 seropositive women in the five reference laboratories, resulting in a 5 % prevalence of infection with T. cruzi in the period 2010-2016. At the beginning of the Program the prevalence was 16 %, the main decrease, to 6 %, was evidenced in 2014 maintaining quasi stationary until 2016. The Chagas disease prenatal diagnosis system and the protocols of prevention by the Ministry of Public Health and Social Welfare were effective. This information is useful to control the congenital transmission through the identification of positive pregnant women and providing the adequate treatment(AU)

Humanos , Feminino , Gravidez , Estudos Soroepidemiológicos , Doença de Chagas , Cuidado Pré-Natal , Trypanosoma cruzi
BMC Infect Dis ; 19(1): 1056, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31842783


BACKGROUND: Toxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii. It is acquired by consumption of raw or undercooked meat containing tissue cyst, food or water contaminated with oocyst and congenital infection through the placenta leading to serious congenital abnormalities in the fetus like miscarriage, stillbirth, intrauterine death and neurologic defects. Therefore; this study was aimed to determine the prevalence of toxoplasmosis infection and its possible risk factors associated with pregnant women attending antenatal clinics in Hawassa and Yiregalem Hospitals, Southern Ethiopia. METHODS: A hospital-based cross-sectional study was conducted from December 2016 to May 2017. The study was done in antenatal care clinics of Hawassa and Yiregalem Hospitals in Southern, Ethiopia. Five hundred pregnant women were interviewed with a pretested structured questionnaire to collect risk factors and socio-demographic data. Blood samples were collected and serum was separated and tested for anti- Toxoplasma gondii antibodies using ELISA (Enzyme-linked Immunosorbent Assay). Data were analyzed using SPSS version 20 statistical software. The risk factors were tested for significance using Bivariate and multivariate analysis. P-value < 0.05 was considered statistically significant. RESULTS: The weighted prevalence of this study was 81.8% for the anti- Toxoplasma gondii antibody. Almost all participants (99.6%) had no information about the disease. A significant association was observed between seroprevalence and contact with domestic cats (OR = 1.206, 95% CI (1.627-2.206, P = 0.043), consumption of raw meat (OR = 0.848, 95% CI: 1.517-2.941, P = 0.019) and unpasteurized milk (OR = 0.871, 95% CI 1.531-2.221, P = 0.032). A significant association was not observed between seroprevalence and age, history of abortion, and blood transfusion. CONCLUSIONS: The findings of this study demonstrated a relatively higher prevalence of seropositivity than studies reported from other countries. Existence of domestic cats at home, consumption of undercooked meat and unpasteurized milk were identified as risk factors for T. gondii infection. Therefore, a health education program to increase the mother's knowledge about toxoplasmosis towards avoiding eating undercooked meat, contact with cats and consumption of unpasteurized milk during pregnancy is recommended. Furthermore, our results suggested that the implementation of newborn screening and follow-up testing can lead to reducing of toxoplasmosis associated complications.

Hospitais Gerais , Complicações Parasitárias na Gravidez/epidemiologia , Cuidado Pré-Natal , Toxoplasma/imunologia , Toxoplasmose/epidemiologia , Universidades , Adolescente , Adulto , Animais , Anticorpos Antiprotozoários/sangue , Estudos Transversais , Ensaio de Imunoadsorção Enzimática , Etiópia/epidemiologia , Feminino , Humanos , Carne/parasitologia , Leite/parasitologia , Mães/psicologia , Animais de Estimação/parasitologia , Gravidez , Prevalência , Alimentos Crus/parasitologia , Fatores de Risco , Estudos Soroepidemiológicos , Inquéritos e Questionários , Toxoplasmose/parasitologia , Adulto Jovem
PLoS Med ; 16(12): e1002990, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31851685


BACKGROUND: In low-resource settings where disease burdens remain high and many health facilities lack essentials such as drugs or commodities, functional equipment, and trained personnel, poor quality of care often results and the impact can be profound. In this paper, we systematically quantify the potential gain of addressing quality of care globally using country-level data about antenatal, childbirth, and postnatal care interventions. METHODS AND FINDINGS: In this study, we created deterministic models to project health outcomes if quality of care was addressed in a representative sample of 81 low- and middle-income countries (LMICs). First, available data from health facility surveys (e.g., Service Provision Assessment [SPA] and Service Availability and Readiness Assessment [SARA]) conducted 2007-2016 were linked to household surveys (e.g., Demographic and Health Surveys [DHS] and Multiple Indicator Cluster Surveys [MICS]) to estimate baseline coverage for a core subset of 19 maternal and newborn health interventions. Next, models were constructed with the Lives Saved Tool (LiST) using country-specific baseline levels in countries with a linked dataset (n = 17) and sample medians applied as a proxy in countries without linked data. Lastly, these 2016 starting baseline levels were raised to reach targets in 2020 as endline based upon country-specific utilization (e.g., proportion of women who attended 4+ antenatal visits, percentage of births delivered in a health facility) from the latest DHS or MICS population-based reports. Our findings indicate that if high-quality health systems could effectively deliver this subset of evidence-based interventions to mothers and their newborns who are already seeking care, there would be an estimated 28% decrease in maternal deaths, 28% decrease in neonatal deaths, and 22% fewer stillbirths compared to a scenario without any change or improvement in quality of care. Totals of 86,000 (range, 77,800-92,400) maternal and 0.67 million (range, 0.59 million-0.75 million) neonatal lives could be saved, and 0.52 million (range, 0.48 million-0.55 million) stillbirths could be prevented across the 81 countries in the calendar year 2020 when adequate quality care is provided at current levels of utilization. Limitations include the paucity of data to individually assess quality of care for each intervention in all LMICs and the necessary assumption that quality of care being provided among the subset of countries with linked datasets is comparable or representative of LMICs overall. CONCLUSIONS: Our findings suggest that efforts to close the quality gap would still produce substantial benefits at current levels of access or utilization. With estimated mortality rate declines of 21%-32% on average, gains from this first step would be significant if quality was improved for selected antenatal, intrapartum, and postnatal interventions to benefit pregnant women and newborns seeking care. Interventions provided at or around the time of childbirth are most critical and accounted for 64% of the impact overall estimated in this quality improvement analysis.

Parto Obstétrico/estatística & dados numéricos , Países em Desenvolvimento/estatística & dados numéricos , Instalações de Saúde/estatística & dados numéricos , Qualidade da Assistência à Saúde/estatística & dados numéricos , Feminino , Humanos , Lactente , Mortalidade Infantil/tendências , Recém-Nascido , Gravidez , Cuidado Pré-Natal/estatística & dados numéricos , Natimorto/epidemiologia