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1.
J Photochem Photobiol B ; 204: 111806, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32044619

RESUMO

The cotton fabrics are a cosmopolitan in usage due to their extraordinary features. The clothes are a very good medium for the growth of pathogenic microorganisms. The nanoparticles have diverse benefits in the biomedical field like drug carrier and as antimicrobials. The current investigation was aimed to synthesize the metallic silver nanoparticles (AgNPs) from the aqueous extract of Curcuma longa leaf and evaluating their antimicrobial and wound healing potential of AgNPs coated cotton fabric. The synthesized AgNPs were characterized by HR-TEM and FT-IR examinations. The formulated AgNPs were coated with cotton fabrics to test their efficiency against the pathogenic microorganisms. The existence of AgNPs in the cotton fabrics was confirmed via the SEM along with EDX analysis. The antimicrobial potential of fabricated AgNPs and its coated cotton fabrics was inspected against the human pathogenic strains. The wound healing efficacy was examined in the L929 cells. The HR-TEM analysis proved the existence of spherical shaped AgNPs. In the antimicrobial activity, the CL-AgNPs loaded cotton fabric was exhibited an appreciable decrease in the growth of pathogenic microorganisms. The crude extract, as well as formulated AgNPs, also exhibited the noticeable antimicrobial potency against the S.aureus, P.aeruginosa, S.pyogenes, and C.albicans. The AgNPs loaded cotton fabrics was displayed the potent wound healing activity in the fibroblast (L929) cells. Consequently, it was concluded that the formulated AgNPs from C.longa coated cotton fabrics may be utilized for the variety of applications in hospital patients and even medical workers to prevent the microbial infection.


Assuntos
Anti-Infecciosos/química , Fibra de Algodão/análise , Curcuma/química , Nanopartículas Metálicas/química , Prata/química , Animais , Anti-Infecciosos/farmacologia , Candida albicans/efeitos dos fármacos , Linhagem Celular , Movimento Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Curcuma/metabolismo , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Química Verde , Nanopartículas Metálicas/toxicidade , Camundongos , Testes de Sensibilidade Microbiana , Extratos Vegetais/química , Folhas de Planta/química , Folhas de Planta/metabolismo
5.
Gene ; 732: 144355, 2020 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-31935501

RESUMO

Curcuma is an important member of Zingiberaceae. Many species of this genus are widely used in traditional medicine and have important cultural value in East Asia. Among them, C. longa is considered to be the main source of curcumin and has a very wide range of uses. The rapid development of molecular phylogeny has deepened our understanding of taxonomy and evolution of Curcuma. However, little is known about the chloroplast genome phylogeny and the genetic bases of adaptative evolution. In this work, we sequenced the complete chloroplast genome of 4 Curcuma species. Curcuma chloroplast genomes showed highly conserved structures and the length ranged from 159,423 bp to 152,723 bp. A total of 133 genes were observed. Multiple repeats and simple sequence repeats (SSRs) were detected. By comparing with related species, 7 highly variable regions were identified as potential specific DNA barcodes for species identification. Phylogenetic analysis of complete plastome sequences and specific data sets revealed discordance with expected genus boundary. Chloroplast phylogenetic relationships were better predicted by geography than by morphological and nuclear DNA, indicating a substantial existence of introgression. 9 genes were proved to have high posteriori probability in positive selection analysis, and 4 of them (psbA, psbD, PetA and rbcL) closely related to photosynthesis, implying that chloroplast genes may had undergone positive selection pressure in evolution. These results are of great significance for us to understand the genetic basis, phylogeny and adaptive evolution of Curcuma chloroplast.


Assuntos
Curcuma/classificação , Genoma de Cloroplastos , Sequenciamento Completo do Genoma/métodos , Cloroplastos/genética , Curcuma/citologia , Curcuma/genética , Evolução Molecular , Tamanho do Genoma , Repetições de Microssatélites , Filogenia
6.
Artigo em Inglês | MEDLINE | ID: mdl-30716389

RESUMO

Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. The cardiovascular protective properties of curcumin in CVDs have been fully illustrated in numerous studies. In this review, we first briefly introduce the medicinal history of curcumin. Secondly, we systematically analyze the preclinical studies of curcumin in CVDs such as cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke and diabetic cardiovascular complications. The potential molecular targets of curcumin are also summarized. Thirdly, the clinical trials of curcumin in CVDs are overviewed and discussed. Finally, we discuss the therapeutic utility of derivatives of curcumin, and highlight existing problems of curcumin as an effective drug lead in treating CVDs.


Assuntos
Doenças Cardiovasculares , Curcumina , Curcuma , Humanos , Estresse Oxidativo , Especiarias
7.
J Sci Food Agric ; 100(4): 1541-1546, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31769025

RESUMO

BACKGROUND: Citrus sinensis, Allium sativum, Ocimum basilicum, Mentha spicata, Curcuma longa, Carica papaya, Andrographis paniculata, Azadirachta indica, Cymbopogon citratus and Acorus calamus were compared in the form of extracts of chloroform, hexane and aqueous media for their effectiveness in repelling Tribolium castaneum. Filter paper of 9 cm in diameter was cut into halves. Using a micro-pipette, each extract was applied to one half of the filter paper. The volume applied was kept constant at 0.6 mL per 30 cm2 . The filter paper was dried and reattached leaving a 0.5 cm gap between, in a Petri-plate. Ten adults of T. castaneum were introduced and the repellency was observed after 30, 60 and 180 min. RESULTS: The aqueous extract of C. papaya exhibited the highest repellency (82-97%) followed by that of garlic bulbs (aqueous extract) with 86.67% repellency. Further, gunny bags were sprayed separately using bottle sprayers with the two most effective extracts at a constant volume of 42 mL per 575 cm2 . These treated gunny bags were compared with malathion-treated gunny bags in the insect management unit. The observations were taken after 2, 8 and 24 h. Papaya leaf extract-treated gunny bags showed relative repellent activity similar to that of malathion-treated gunny bags after 24 h of treatment. Thus, gas chromatography-mass spectrometry analysis of aqueous extract of papaya leaves was performed. CONCLUSIONS: It can be concluded that extract of papaya leaves containing 2-methoxy-4-vinylphenol (8.47% peak area) can be used as a repellent biopesticide. © 2019 Society of Chemical Industry.


Assuntos
Repelentes de Insetos/farmacologia , Extratos Vegetais/farmacologia , Tribolium/efeitos dos fármacos , Andrographis/química , Animais , Azadirachta/química , Carica/química , Curcuma/química , Cymbopogon/química , Alho/química , Repelentes de Insetos/química , Repelentes de Insetos/isolamento & purificação , Mentha spicata/química , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Tribolium/fisiologia
8.
Int J Vitam Nutr Res ; 90(1-2): 141-150, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30789805

RESUMO

Anti-inflammatory effect of Curcuma longa (C. longa) was shown previously. In the present study, the effect of the plant on tracheal responsiveness and lung pathological features in ovalbumin-sensitized rats was evaluated. Six groups of rats including control (C), ovalbumin (OVA)-sensitized (S), S groups treated with C. longa (CL; 0.75, 1.50, and 3.00 mg/ml equal to 150, 300 and 600 mg/kg/day) and dexamethasone (D; 1.25 µg/ml) were studied (n=8 in each group). The extract of C. longa and dexamethasone were administered with daily drinking water of animals during sensitization period (for 21 days). Following the treatment period, tracheal responsiveness to methacholine and ovalbumin and lung pathological features was investigated. Tracheal responsiveness to methacholine and OVA and lung pathological scores were increased in group S compared to controls (p<0.01 to p<0.001); however, these parameters in groups treated with dexamethasone and two higher concentrations of C. longa were significantly decreased compared to group S (p<0.05 to p<0.001). Tracheal responsiveness to methacholine was decreased from 50 to 400% due to the extract treatment. All concentrations of C. longa significantly decreased interstitial fibrosis compared to group S (p<0.05 to p<0.001). Treatment with the extract resulted to improvement of pathological changes from 20 to 70%. These results showed a preventive effect for C. longa extract on tracheal responsiveness and lung pathological insults in sensitized rats which were similar or even more than those of dexamethasone at used concentrations.


Assuntos
Curcuma , Pulmão/efeitos dos fármacos , Cloreto de Metacolina/farmacologia , Extratos Vegetais , Traqueia/efeitos dos fármacos , Animais , Pulmão/patologia , Cloreto de Metacolina/química , Ovalbumina , Extratos Vegetais/farmacologia , Ratos , Traqueia/patologia
9.
J Ethnopharmacol ; 246: 111768, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-30849507

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma wenyujin Y.H. (CW), a variety of Curumae Rhizoma, which documented in China Pharmacopeia, has long been used as plant medicine for its traditional effect on promoting Qi, activating blood stagnation and expelling blood stasis. Nowadays, it is often used in clinic for extraordinary effect on liver diseases. It is worthy to be noted that CW processed with vinegar has been applied in clinic for 1500 years which started in the northern and southern dynasties. AIM OF STUDY: Liver fibrosis is a worldwide clinical issue. It is worth developing a multi-target and multicellular approach which is high efficiency and low side effects for the treatment of hepatic fibrosis. The anti-hepatic fibrosis molecular mechanisms of CW and vinegar Curcuma wenyujin (VCW) need to be explored and elucidated. Furthermore, the study aimed to discuss the efficiency and mechanism differences between CW and VCW in hepatic fibrosis. METHODS AND RESULTS: Biochemical assays and histopathology were adopted to evaluate the anti-hepatic fibrosis effect of CW and VCW. The TGF-ß/Smad signaling involving TGF-ß1, TGF-ßRⅠ, TGF-ßRⅡ and Smad2, Smad3, Smad7 in fibrosis is examined, which is a critical step towards the evaluation of anti-hepatic fibrosis agents. Meanwhile, the MMP/TIMP balance is a potential therapy target by modulating extracellular matrix, which is also examined. Both CW and VCW inhibit the activation and proliferation of hepatic stellate cells and induce apoptosis via blocking TGF-ß/Smad signaling pathways. Additionally, the level of MMP-2/TIMP-1 regulated significantly, which suggest CW and VCW participate in the degradation process, and maintain the formation and production of extracellular matrix. CONCLUSION: Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-ß/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio. And VCW has more exhibition than CW.


Assuntos
Curcuma , Cirrose Hepática/metabolismo , Extratos Vegetais/farmacologia , Ácido Acético/química , Animais , Linhagem Celular , Fígado/efeitos dos fármacos , Fígado/patologia , Cirrose Hepática/genética , Cirrose Hepática/patologia , Masculino , Metaloproteinase 2 da Matriz/genética , Metaloproteinase 2 da Matriz/metabolismo , Ratos Sprague-Dawley , Transdução de Sinais/efeitos dos fármacos , Proteína Smad2/genética , Proteína Smad2/metabolismo , Proteína Smad3/genética , Proteína Smad3/metabolismo , Inibidor Tecidual de Metaloproteinase-1/genética , Inibidor Tecidual de Metaloproteinase-1/metabolismo , Fator de Crescimento Transformador beta1/genética , Fator de Crescimento Transformador beta1/metabolismo
10.
Food Chem ; 305: 125458, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31505416

RESUMO

The purpose of the present study was to elucidate the effects of feeding flaxseed meal (FSM) and turmeric rhizome powder (TRP) supplementation on tissue lipid profile, lipid metabolism, health indices, oxidative stability, and physical properties of broiler chicken meat. The 100 g FSM along with 10.0 g TRP supplementation significantly increased the ω-3 PUFA, particularly ALA, EPA, DPA, and DHA of broiler chicken meat due to the corresponding increase ∆9 and Δ5 + Δ6 desaturase activities. The increased activities of the desaturases resulted in significantly better health indices of the broiler chicken meat. The feeding of 100 g FSM along with 10.0 g TRP supplementation reduced the atherogenic and thrombogenic indices of broiler chicken meat. The 100 g FSM feeding reduced the oxidative stability, water holding capacity, extract release volume of broiler chicken meat and increased drip loss, whereas, 10.0 g TRP supplementation reversed these negative effects of FSM.


Assuntos
Ração Animal/análise , Curcuma/metabolismo , Ácidos Graxos Ômega-3/análise , Linho/metabolismo , Carne/análise , Animais , Antioxidantes/química , Galinhas , Dieta , Ácidos Graxos Ômega-3/metabolismo , Peroxidação de Lipídeos , Oxirredução , Estearoil-CoA Dessaturase/metabolismo
11.
Braz. dent. sci ; 23(1): 1-8, 2020. ilus, tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1049266

RESUMO

Background: Zinc oxide eugenol(ZOE) has long been the material of choice for obturating primary teeth,but it is resistant to resorption, might result in a deflected successor and has limited antibacterial efficacy. Curcuminpossessesanti-inflammatory and antimicrobialproperties which can be implied by its use as obturating material in primary teeth. Objective: To evaluate and compare the efficacy of Curcumin Gel mixed Endoflas powderand Zinc oxide eugenol as obturating materials in primary molars. Material and methods: A total of 30 primary molars indicated for pulpectomy were selected from 4-9-yearold children and divided into two equal groups based on the obturating material used. Group 1- Curcumin Gel mixed Endoflas powder(CGE) and Group 2- Zinc oxide eugenol(ZOE). The efficacy of these obturation materials was evaluatedboth clinically and radiographically. Follow-up was done after 1, 3 and 6months to evaluate clinical and radiographical success rates. The results were subjected to statistical analysis using SPSS software version 21 using chisquare test. Results: At the end of the 6th month follow-up,there was 93.3% clinical success in Group 1 compared with 86.6% success in Group 2. Whereas, radiographically success reported was 100% with Group 1 and 93.3% with Group 2. The difference in the radiographic success rate between the two Groups was statistically significant (P < 0.05). Conclusion: Based on the present study results, Curcumin Gel mixed Endoflas powder can be considered as an alternative obturation material for treating deciduous molars with extensive involvement of pulp and periradicular tissues.(AU)


Fundamentação: O óxido de zinco eugenol (OZE) há muito tempo é o material de escolha para a obturação de dentes decíduos, mas é resistente à reabsorção, podendo resultar em um dente permanente desviado e tem eficácia antibacteriana limitada. A curcumina possui propriedades anti-inflamatórias e antimicrobianas que podem indicar seu emprego como material obturador em dentes decíduos. Objetivo: Avaliar e comparar a eficácia da pasta de curcumina Endoflas e do óxido de zinco eugenol como materiais obturadores em molares decíduos. Material e métodos: Um total de 30 molares decíduos indicados para pulpectomia foram selecionados entre crianças de 4 a 9 anos e divididos em dois grupos iguais, com base no material obturador utilizado. Grupo 1 - pasta de curcumina Endoflas (CGE) e Grupo 2- óxido de zinco eugenol (ZOE). A eficácia desses materiais de obturação foi avaliada clinicamente e radiograficamente. O acompanhamento foi realizado após 1, 3 e 6 meses para avaliar as taxas de sucesso clínico e radiográfico. Os resultados foram submetidos à análise estatística no software SPSS versão 21, utilizando o teste quiquadrado. Resultados: No final do sexto mês de acompanhamento, houve 93,3% de sucesso clínico no Grupo 1 em comparação com 86,6% de sucesso no Grupo 2. Considerando que, o sucesso radiográfico relatado foi de 100% no Grupo 1 e 93,3% no Grupo 2. A diferença na taxa de sucesso radiográfico entre os dois grupos foi estatisticamente significante (P < 0,05). Conclusão: Com base nos resultados do presente estudo, a pasta de curcumina Endoflas pode ser considerada como um material de obturação alternativo para o tratamento de molares decíduos com amplo envolvimento de polpa e tecidos perirradiculares (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Obturadores Palatinos , Pulpectomia , Cimento de Óxido de Zinco e Eugenol , Curcuma , Anti-Infecciosos
12.
Phytochem Anal ; 31(1): 28-36, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31243828

RESUMO

INTRODUCTION: Curcuma caesia (black turmeric), an essential oil-bearing rhizomatous herb has been a part of ethnomedicinal practices in India and southeast Asian countries since ancient time. Oleochemical profile of black turmeric has been investigated previously by gas chromatography coupled to mass spectrometry (GC-MS) technique from different geographical regions showing a large variation in the identity as well as abundance of the constituents. OBJECTIVES: To develop an analytical method for the reliable analysis of essential oil from black turmeric rhizome through identified chemical markers and to show the credibility of the developed method on real samples. METHODS: The essential oil of black turmeric was analysed through proton nuclear magnetic resonance (1 H-NMR) based method using an internal standard. RESULTS: Four thermolabile sesquiterpene markers were unambiguously identified from the essential oil of black turmeric rhizome. GC-MS based analysis produced an erroneous identification of the constituents. A standardised 1 H-NMR spectroscopy based method was developed for the qualitative and quantitative analysis of the identified chemical markers. The developed method was further utilised for analysing the variation in oleochemical profile across multiple batches of harvest and the rhizomes subjected to different post-harvest storage or drying conditions. CONCLUSION: The identified marker molecules and developed 1 H -NMR spectroscopic method might prove to be a useful tool for the analysis of essential oil and quality control of this endangered crop material. Also, the present study provided information on the preferred drying and storage condition of black turmeric rhizome prior to the extraction of essential oil.


Assuntos
Curcuma , Óleos Voláteis , Índia , Espectroscopia de Ressonância Magnética , Rizoma
13.
Arq Bras Cir Dig ; 32(3): e1456, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31826083

RESUMO

BACKGROUND: Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition. AIM: To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats. METHOD: Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion. RESULTS: The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642). CONCLUSION: Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.


Assuntos
Colite/tratamento farmacológico , Curcuma/química , Extratos Vegetais/administração & dosagem , Administração Retal , Animais , Colite/patologia , Colite/cirurgia , Colostomia , Modelos Animais de Doenças , Masculino , Ratos , Ratos Wistar
14.
BMC Complement Altern Med ; 19(1): 293, 2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31684927

RESUMO

BACKGROUND: Numerous health benefits have been demonstrated for curcumin which is extracted from turmeric (Curcuma longa L). However, due to its poor absorption in the free form in the gastrointestinal tract and rapid biotransformation, various formulations have been developed to enhance its bioavailability. Previous studies indicate that the free form of curcumin is more bioactive than its conjugated counterparts in target tissues. Most curcumin pharmacokinetics studies in humans designed to assess its absorption and bioavailability have measured and reported total (free plus conjugated) curcumin, but not free, bioactive curcumin in the plasma because enzymatic hydrolysis was employed prior to its extraction and analysis. Therefore, the bioavailability of free curcumin cannot be determined. METHODS: Eight human subjects (4 male, 4 female) consumed a single dose of 400 mg curcumin in an enhanced absorption formulation, and blood samples were collected over 6 h. Plasma was treated either with or without glucuronidase/sulfatase prior to extraction. Curcumin and its major metabolites were analyzed using HPLC-tandem mass spectrometry. In addition, the literature was searched for pharmacokinetic studies involving curcumin using PubMed and Google Scholar, and the reported bioavailability data were compared based on whether hydrolysis of plasma samples was used prior to sample analysis. RESULTS: Hydrolysis of blood plasma samples prior to extraction and reporting the results as "curcumin" obscures the amount of free, bioactive curcumin and total curcuminoids as compared to non-hydrolyzed samples. As a consequence, the data and biological effects reported by most pharmacokinetic studies are not a clear indication of enhanced plasma levels of free bioactive curcumin due to product formulations, leading to a misrepresentation of the results of the studies and the products when enzymatic hydrolysis is employed. CONCLUSIONS: When enzymatic hydrolysis is employed as is the case with most studies involving curcumin products, the amount of free bioactive curcumin is unknown and cannot be determined. Therefore, extreme caution is warranted in interpreting published analytical results from biological samples involving ingestion of curcumin-containing products. TRIAL REGISTRATION: ClinicalTrails.gov, trial identifying number NCT04103788 , September 24, 2019. Retrospectively registered.


Assuntos
Curcumina/análise , Glucuronidase/química , Plasma/química , Sulfatases/química , Curcuma/química , Curcumina/metabolismo , Feminino , Humanos , Hidrólise , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
16.
BMC Complement Altern Med ; 19(1): 252, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31506082

RESUMO

BACKGROUND: Turmeric is commonly used as a dietary treatment for inflammation, but few studies have evaluated the direct effect of turmeric on cartilage. The purpose of this study was to characterize cartilage explants' inflammatory responses to lipopolysaccharide in the presence of a simulated biological extract of turmeric. METHODS: Turmeric was incubated in simulated gastric and intestinal fluid, followed by inclusion of liver microsomes and NADPH. The resulting extract (TURsim) was used to condition cartilage explants in the presence or absence of lipopolysaccharide. Explants were cultured for 96 h (h); the first 24 h in basal tissue culture media and the remaining 72 h in basal tissue culture media containing TURsim (0, 3, 9 or 15 µg/mL). Lipopolysaccharide (0 or 5 µg/mL) was added for the final 48 H. media samples were collected immediately prior to lipopolysaccharide exposure (0 h) and then at 24 and 48 h after, and analyzed for prostaglandin E2 (PGE2), glycosaminoglycan (GAG), and nitric oxide (NO). Explants were stained with calcein-AM for an estimate of live cells. Data were analyzed using a 2-way repeated measures (GAG, PGE2, NO) or 1-way ANOVA without repeated measures (viability). Significance accepted at p < 0.05. RESULTS: TURsim significantly reduced PGE2, NO and GAG, and calcein fluorescence was reduced. CONCLUSIONS: These data contribute to the growing body of evidence for the utility of turmeric as an intervention for cartilage inflammation.


Assuntos
Anti-Inflamatórios/farmacologia , Cartilagem/efeitos dos fármacos , Curcuma/química , Extratos Vegetais/farmacologia , Animais , Cartilagem/imunologia , Dinoprostona/imunologia , Glicosaminoglicanos/imunologia , Técnicas In Vitro , Lipopolissacarídeos/efeitos adversos , Lipopolissacarídeos/imunologia , Masculino , Óxido Nítrico/imunologia , Ratos , Suínos
17.
Nutrients ; 11(8)2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31394768

RESUMO

To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 µg bisacurone, 80 µg turmeronol A and 20 µg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.


Assuntos
Biomarcadores/sangue , Curcuma/química , Hipertensão/sangue , Inflamação/sangue , Sobrepeso/sangue , Extratos Vegetais/farmacologia , Idoso , Cicloexanóis/administração & dosagem , Método Duplo-Cego , Humanos , Saúde Mental , Pessoa de Meia-Idade , Placebos , Pré-Hipertensão/sangue , Sesquiterpenos/administração & dosagem , Água
18.
Nutrients ; 11(8)2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31398884

RESUMO

Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. The multifactorial nature of the pathology makes patient management, which includes lifelong drug therapy and lifestyle modification, extremely challenging. It is well known that T2DM is a preventable disease, therefore lowering the incidence of new T2DM cases could be a key strategy to reduce the global impact of diabetes. Currently, there is growing evidence on the efficacy of the use of medicinal plants supplements for T2DM prevention and management. Among these medicinal plants, curcumin is gaining a growing interest in the scientific community. Curcumin is a bioactive molecule present in the rhizome of the Curcuma longa plant, also known as turmeric. Curcumin has different pharmacological and biological effects that have been described by both in vitro and in vivo studies, and include antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic, hepato-protective, immunomodulatory, hypoglycaemic and anti-rheumatic effects. In animal models, curcumin extract delays diabetes development, improves ß-cell functions, prevents ß-cell death, and decreases insulin resistance. The present review focuses on pre-clinical and clinical trials on curcumin supplementation in T2DM and discusses the peculiar mechanisms by which curcumin might ameliorate diabetes management.


Assuntos
Curcumina/farmacologia , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/prevenção & controle , Hipoglicemiantes/farmacologia , Fitoterapia/métodos , Extratos Vegetais/farmacologia , Animais , Ensaios Clínicos como Assunto , Curcuma , Humanos , Plantas Medicinais
19.
Molecules ; 24(15)2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31374848

RESUMO

Curcumin from Curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumin (Cs) on blood pressure, electrocardiogram, and biological changes on isoproterenol (ISO)-induced myocardial infarction (MI) in rats had been investigated. The Cs doses of 150 and 200 mg/kg bw and all nC doses (100, 150 and 200 mg/kg bw) significantly reduced heart rate before ISO administration and prevented QRS complex enlargement after MI induction (p < 0.026). All doses of Cs and nC prevented prolongation of the QT and QT corrected (QTc) intervals, with better results for higher doses (p < 0.048). The nC solution had more significant results than Cs in all metabolic parameters assessed (lactate dehydrogenase, glycaemia, aspartate transaminase, and alanine transaminase, p < 0.009). nC was more efficient than Cs in limiting myocardial oxidative stress and enhancing antioxidative capacity (p < 0.004). Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation. Curcumin nanoparticles as compared to conventional curcumin exert better antioxidative effects. Moreover, nC better prevent cardiomyocytes damage, and electrocardiogram alterations, in the case of ISO-induced MI in rats.


Assuntos
Curcumina/farmacologia , Coração/efeitos dos fármacos , Infarto do Miocárdio/tratamento farmacológico , Nanopartículas/química , Animais , Antioxidantes/química , Antioxidantes/farmacologia , Cardiotônicos/química , Cardiotônicos/farmacologia , Curcuma/química , Curcumina/química , Modelos Animais de Doenças , Glutationa/química , Coração/fisiopatologia , Humanos , Isoproterenol/toxicidade , Infarto do Miocárdio/induzido quimicamente , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Ratos
20.
Molecules ; 24(16)2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31412624

RESUMO

Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), a lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, and anti-aging agent as suggested by several in vitro, in vivo studies and clinical trials. However, poor aqueous solubility, bioavailability, and pharmacokinetic profiles limit curcumin's therapeutic usage. To address these issues, several curcumin formulations have been developed. However, suboptimal sample preparation and analysis methodologies often hamper the accurate evaluation of bioactivities and their clinical efficacy. This review summarizes recent research on biological, pharmaceutical, and analytical aspects of the curcumin. Various formulation techniques and corresponding clinical trials and in vivo outcomes are discussed. A detailed comparison of different sample preparation (ultrasonic, pressurized liquid extraction, microwave, reflux) and analytical (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, and LC-MS/MS) methodologies used for the extraction and quantification of curcuminoids in different matrices, is presented. Application of optimal sample preparation, chromatographic separation, and detection methodologies will significantly improve the assessment of different formulations and biological activities of curcuminoids.


Assuntos
Curcumina/química , Curcumina/farmacologia , Animais , Curcuma/química , Curcuma/metabolismo , Curcumina/isolamento & purificação , Suplementos Nutricionais/análise , Composição de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Humanos , Estrutura Molecular , Preparações Farmacêuticas/análise , Preparações Farmacêuticas/química , Relação Estrutura-Atividade
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