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1.
PLoS One ; 16(1): e0241898, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33406080

RESUMO

Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH's development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.


Assuntos
Hipoplasia do Esmalte Dentário/genética , Interação Gene-Ambiente , Genótipo , Incisivo/crescimento & desenvolvimento , Dente Molar/crescimento & desenvolvimento , Polimorfismo de Nucleotídeo Único , Fator de Crescimento Transformador alfa/genética , Adolescente , Amelogênese/genética , Criança , Feminino , Humanos , Incisivo/patologia , Masculino , Dente Molar/patologia
2.
Rev. ADM ; 77(6): 329-336, nov.-dic. 2020. ilus
Artigo em Espanhol | LILACS | ID: biblio-1151749

RESUMO

La mediastinitis se define como una inflamación aguda severa de los tejidos conectivos ubicados en la cavidad torácica media, en la que 20% de los casos puede implicar una infección difusa y polimicrobiana del mediastino denominada mediastinitis necrotizante descendente (MND), secundaria a la propagación de una infección grave desde los tejidos bucofaríngeos o cervicales tales como infecciones odontogénicas (de 36 a 47%), faríngeas (de 33 a 45%), cervicales (15%) y otras infecciones de cabeza y cuello (5%). Clínicamente, los pacientes presentan aumento de volumen, temblores, trismus, odinofagia con disnea, disfagia, hipotensión, dolor de cuerpo y del ángulo de la mandíbula. Puede observarse signo de Hamman (crepitación mediastinal con el latido cardiaco) y enfisema subcutáneo. El manejo quirúrgico de las infecciones odontogénicas, sin importar su severidad, consta de dos principios: eliminar el foco etiológico y el vaciamiento quirúrgico de los espacios anatómicos comprometidos con la instalación de un drenaje adecuado. Se presenta el caso de un masculino de 60 años con diagnóstico de mediastinitis necrotizante descendente de origen dental (AU)


Mediastinitis is defined as a severe acute inflammation of the connective tissues affected in the middle thoracic cavity, in which 20% of cases may involve a diffuse and polymicrobial infection of the mediastinum, descending necrotizing mediastinitis (MND), secondary to the spread of a serious infection from the oropharyngeal or cervical tissues, stories such as odontogenic infections (36 to 47%), pharyngeal (33 to 45%), cervical (15%) and other head and neck infections (5%). Clinically, patients present with increased volume, tremors, trismus, odynophagia with dyspnea, dysphagia, hypotension, pain in the body and in the angle of the jaw. Hamman sign (mediastinal crepitus with heartbeat) and subcutaneous emphysema may be observed. The surgical management of odontogenic infections, regardless of their severity, consists of two principles: eliminate the etiological focus and the surgical emptying of the anatomical spaces compromised with the installation of adequate drainage. We present the case of a 60-year-old man diagnosed with descending necrotizing (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Infecção Focal Dentária/complicações , Mediastinite , Complicações Pós-Operatórias , Enfisema Subcutâneo , Extração Dentária , Cavidade Torácica , Mandíbula , México , Dente Molar/patologia
3.
Acta Odontol Latinoam ; 33(2): 90-97, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32920610

RESUMO

The aim of this study was to determine the caries situation of three-year-old preschool children residing in low socioeconomic status districts in Lima, Peru. The study is a crosssectional analysis of the caries situation of suburban areas of Lima. A stratified sampling procedure by geographical distribution, considering healthcare centers with a motherand- child health clinic and surrounding preschools as factors, identified 45 randomly selected preschools, of which 17 accepted to participate. Children from 3-year-old classrooms were examined by two independent calibrated dentists using the Caries Assessment Spectrum and Treatment (CAST) instrument at their premises using artificial light, sterile examination mirrors and gauze for drying each tooth before evaluation. ANOVA and the Tamhane method were used to analyze the data. 308 children, mean age 3.4 years (min: 3 years; max: 3 years, 7 months), were examined. The sample prevalence of enamel and dentine carious lesions (CAST code 3-7) was 91.2% while the prevalence of dentine carious lesions (CAST code 4-7) was 58.8%. The mean number of teeth with cavities that had reached the pulp and those that had an abscess or fistula were 2.0% and 0.5% respectively. The majority of enamel and dentine carious lesions were observed in molars. The CAST severity score was 7.0. Mean examination time was 57 seconds. The burden of dental caries of the children at this young age was high.


Assuntos
Cárie Dentária/epidemiologia , Dente Molar/patologia , Pré-Escolar , Estudos Transversais , Cárie Dentária/classificação , Esmalte Dentário/patologia , Feminino , Humanos , Masculino , Peru/epidemiologia , Prevalência , Reprodutibilidade dos Testes , Fatores Socioeconômicos , População Suburbana
4.
West Afr J Med ; 37(3): 253-259, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32476119

RESUMO

BACKGROUND: Stainless steel crown (SSC) restoration is one of the restorative treatment options in the management of carious primary molars. The Hall technique is a biologic method of managing carious primary teeth by sealing in the caries with SSCs without the routine local anaesthesia and tooth preparations. The objectives of this study was to compare the treatment assessments of the conventional stainless steel crown restoration with Hall technique using subjects' discomfort during treatments and parents' treatment perception, treatment acceptability and satisfaction with the treatment. METHODS: The study was a comparative analytical study involving the placement of 25 SSC restorations using the conventional method and 25 SSC restorations using the Hall technique in 25 subjects aged 3-8 years with a pair or pairs of unrestored enamel or dentinal carious primary molars matched for tooth type, dental arch and extent of caries. Discomfort during the placements of the SSCs was assessed by the subjects while treatment perception, acceptability and satisfaction were assessed by the parents with the use of questionnaires. RESULTS: There was statistically significant difference (p-value 0.00001) between the conventional method and the Hall technique for the discomfort outcomes. There was no statistically significant difference for treatment perception (p=0.73), acceptability (0.72) and satisfaction (0.60). CONCLUSION: The Hall Technique compared favourably well with the conventional method in treatment perception, acceptability and satisfaction but it gave higher level of discomfort in some of the subjects. The Hall Technique appears to be a good method for managing dental caries in primary molar teeth especially in a resource challenged environment where electricity and access to care are contending issues.


Assuntos
Coroas , Assistência Odontológica para Crianças/métodos , Cárie Dentária/terapia , Restauração Dentária Permanente/métodos , Cimentos de Resina/uso terapêutico , Aço Inoxidável , Criança , Pré-Escolar , Ligas Dentárias , Humanos , Dente Molar/patologia , Dente Decíduo/patologia , Resultado do Tratamento
5.
Cient. dent. (Ed. impr.) ; 17(1): 19-26, ene.-abr. 2020. ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-189745

RESUMO

La pérdida ósea vertical en los sectores posteriores maxilares es un hecho frecuente tras la extracción dental. En muchas ocasiones para rehabilitar estas zonas podemos emplear técnicas de regeneración u optar por un abordaje más conservador con implantes cortos. En el presente caso clínico mostramos un caso rehabilitado bilateralmente con dos técnicas diferentes: elevación de seno y la inserción de implantes cortos, con un seguimiento de ocho años donde ambas técnicas han logrado resultados igualmente predecibles


Vertical bone loss in the posterior maxillary sectors is a frequent occurrence after tooth extraction. These areas can often be rehabilitated using regeneration techniques or by opting for a more conservative approach with short implants. The present clinical case shows bilateral rehabilitation with two different techniques: sinus lift and the insertion of short implants, with a follow-up of 8 years where both techniques have achieved equally predictable results


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Atrofia , Maxila/cirurgia , Levantamento do Assoalho do Seio Maxilar/métodos , Implantes Dentários , Maxila/patologia , Dente Molar/patologia , Radiografia Panorâmica
7.
Artigo em Inglês | MEDLINE | ID: mdl-32098396

RESUMO

The aim of this study was to evaluate the risk factors associated with the occurrence of caries in permanent teeth (PT) and in the permanent first molar (PFM) seven years after their eruption. Children born in 2005 who were enrolled in a Community Dental Program were included. A total of 278 children were enrolled. Evaluated risk factors were parental caries experience, educational level of the mother, routine medications, systemic diseases, dietary habits, toothbrushing frequency, existence of molar incisor hypomineralization (MIH) in the PT, and caries in the temporary teeth (TT). Associations between independent variables and the DMF-T (decayed, missing, and filled teeth in PT) and DMF-M (DMF in PFM) indices, only considering cavitated and non-cavitated carious lesions or cavitated carious lesions as outcomes, were evaluated by Poisson regression with robust variance analysis. A cariogenic diet (sweets and soft drinks), toothbrushing frequency of <1 a day, a presence of df-t (decayed and filled temporary teeth) score of >0, low educational level of the mother, and existence of MIH were associated with high DMF-T or DMF-M values (p < 0.05). We can conclude that the intake of sweets and soft drinks, toothbrushing frequency, the presence of caries in TT, and MIH in PT were the best predictors of the occurrence of caries in PT and PFM.


Assuntos
Cárie Dentária , Dente Molar , Adolescente , Criança , Índice CPO , Cárie Dentária/epidemiologia , Dentição Permanente , Dieta , Feminino , Humanos , Dente Molar/patologia , Estudos Retrospectivos , Fatores de Risco , Escovação Dentária
8.
Sci Rep ; 10(1): 2578, 2020 02 13.
Artigo em Inglês | MEDLINE | ID: mdl-32055001

RESUMO

The high prevalence and heavy socio-economic burden for caries of first permanent molars (FPMs) make the prevention of this disease a major public health goal. Current guidelines recommend a preference of fissure sealant (FS) over fluoride varnish (FV) based on two recent systematic reviews. However, evidences of these two studies are weak because of scarce data and some limitations. Besides, an up-to-date large scale randomized controlled trial (RCT) reported commensurate effectiveness of these two techniques. Thus, in order to more accurately compare the clinical efficacy between FS and FV on caries prevention for FPMs, we carried out this systematic review and meta-analysis. A total of 8 RCTs involving 3289 participants and 6878 FPMs fulfilled the inclusion criteria. Our meta-analysis for the first time showed that there was no statistical difference on caries incidence or occlusal DMFS increment between sealant group and fluoride varnish group at 2~3 years' follow-up. In that sense, biannual applications of FV or FS may be equally effective on caries prevention for FPMs. These results do not support routine recommendation of FS over FV, thus shedding light on current conceptions. Our findings endow clinicians with a window to reconsider the choice between these two techniques.


Assuntos
Cárie Dentária/tratamento farmacológico , Fluoretos Tópicos/uso terapêutico , Dente Molar/efeitos dos fármacos , Selantes de Fossas e Fissuras/uso terapêutico , Cárie Dentária/patologia , Cárie Dentária/prevenção & controle , Guias como Assunto , Humanos , Dente Molar/patologia
9.
Int J Oral Sci ; 12(1): 7, 2020 02 21.
Artigo em Inglês | MEDLINE | ID: mdl-32080164

RESUMO

Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to generate transcriptomes of furcal bone from infraoccluded (n = 7) and non-infraoccluded (n = 9) primary second molars, all without succeeding biscuspids. Of the 18 529 expressed genes, 432 (2.3%) genes were differentially expressed between the two groups (false discovery rate < 0.05). Hierarchical clustering and principal component analysis showed clear separation in gene expression between infraoccluded and non-infraoccluded samples. Pathway analyses indicated that molar ankylosis is associated with the expression of genes consistent with the cellular inflammatory response and epithelial cell turnover. Independent validation using six expressed genes by immunohistochemical analysis demonstrated that the corresponding proteins are strongly expressed in the developing molar tooth germ, in particular the dental follicle and inner enamel epithelium. The descendants of these structures include the periodontal ligament, cementum, bone and epithelial rests of Malassez; tissues that are central to the ankylotic process. We therefore propose that ankylosis involves an increased inflammatory response associated with disruptions to the developmental remnants of the dental follicle and epithelial rests of Malassez.


Assuntos
Perfilação da Expressão Gênica , Ligamento Periodontal , Anquilose Dental/genética , Anquilose Dental/patologia , Adolescente , Criança , Cemento Dentário/patologia , Feminino , Humanos , Masculino , Má Oclusão/etiologia , Má Oclusão/genética , Má Oclusão/patologia , Dente Molar/patologia , Análise de Sequência de RNA , Técnicas de Movimentação Dentária , Dente Decíduo/patologia
10.
Lasers Med Sci ; 35(5): 1185-1191, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31970563

RESUMO

The aim of this controlled randomized double-blinded clinical trial was to evaluate the use of a CO2 laser with or without topical application of acidulated fluorides in the prevention of dental caries in partially erupted first permanent molars. We selected 61 healthy children at high risk of caries, all between 6 and 8 (7.1 ± 0.8) years of age and with 4 partially erupted first permanent molars. A CO2 laser device emitting at 10.6 µm was used (0.5 W, 0.05 mJ per pulse, 10 kHz). Each first molar in an individual was randomly assigned to one treatment: (L) CO2 laser (0.066 J/cm2); (FL) 1.23% acidulated fluoride gel and CO2 laser (0.066 J/cm2); (V) 5% fluoride varnish, or (S) sealant (control). Patients were followed-up at 3, 6, 12, and 18 months after treatment, through direct visual examination and by an operator blinded to the treatments (kappa ≥ 0.70). The International Caries Detection and Assessment System (ICDAS-II) index was used to assess the soundness of tooth structure or the presence of white spot lesions, cavitated enamel, and/or dentin lesions. The Yildiz Visual Index was used to evaluate sealant retention. Results were evaluated using Kaplan-Meier survival analysis, and the hazard ratio of the treatments was estimated using shared frailty models with a gamma distribution, which considered the patient as a cluster. There were no significant differences among treatments compared to sealants. After 18 months, the use of a CO2 laser with or without acidulated fluorides was shown to be effective in preventing caries on the occlusal surface of partially erupted permanent first molars in children at high risk for caries.


Assuntos
Cárie Dentária/prevenção & controle , Lasers de Gás/uso terapêutico , Dente Molar/efeitos da radiação , Erupção Dentária/efeitos da radiação , Criança , Cárie Dentária/epidemiologia , Cárie Dentária/patologia , Feminino , Seguimentos , Humanos , Incidência , Masculino , Dente Molar/patologia , Selantes de Fossas e Fissuras/uso terapêutico , Modelos de Riscos Proporcionais , Resultado do Tratamento
11.
Vet J ; 255: 105421, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31982081

RESUMO

Fissures on the occlusal surface of equine cheek teeth are commonly encountered during oral examination. Generally, their presence is considered abnormal but their aetiopathogenesis and clinical impact on pulp disease is still undetermined. The aims of this research were to study the extent of occlusal cheek teeth fissures using high-resolution X-ray computed tomography (µCT) imaging and their histological characteristics. Twenty-seven teeth (of 15 horses) were scanned using µCT imaging to analyse fissure extent. Histological examination of a subset of teeth (n=7) was performed. Forty-three type 1 fissures (35 type 1a, eight type 1b) were identified. The mean length of the fissure of type 1a and type 1b on the occlusal surface was 3.47+/-1.60mm and 13.64+/-7.40mm, respectively. Their mean depth was 13.22+/-10.76mm and 7.42+/-6.42mm, respectively. Potential risk factors associated with fissure depth were identified using a multivariable mixed model The location of the fissure and Triadan number were significantly associated with fissure depth. Fissures could be identified on histological sections with the presence of organic material inside the fissure, microorganisms in the continuation of the fissure extending into the dentinal tubules and the presence of reactionary dentine. This study suggests that fissures can provide a pathway for microorganisms to enter the dentinal tubules, potentially resulting in local pulpal inflammation. It appears that in healthy teeth, vital odontoblasts react by producing reactionary (tertiary) dentin, which lacks patent tubules and thus provides a proper seal.


Assuntos
Fissuras Dentárias/veterinária , Doenças dos Cavalos/patologia , Dente Molar/patologia , Animais , Fissuras Dentárias/diagnóstico por imagem , Fissuras Dentárias/epidemiologia , Fissuras Dentárias/microbiologia , Dentina/patologia , Doenças dos Cavalos/epidemiologia , Cavalos , Tomografia Computadorizada por Raios X/veterinária
12.
Clin Oral Investig ; 24(3): 1287-1297, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31312969

RESUMO

OBJECTIVES: Hypomineralised second primary molars (HSPM) are due to idiopathic hypomineralisation that affects from 1- to 4-s primary molars, and its aetiology remains unclear. Our objective was to systematically review studies in which the investigators had studied the association between HSPM and drug use during pregnancy and the first year of life. MATERIALS AND METHODS: A systematic search for publications until July 2018 was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. No restrictions were placed on year of publication. The PECO Question was as follows: P, children exposed to drugs during pregnancy and the first year of life; E, drugs to which mothers, during pregnancy and their offspring were exposed; C, control groups from studies with the same characteristics not exposed to drugs during pregnancy and the first year of life; and O, relationship between drug exposure during pregnancy and the first year of life and HSPM. Two reviewers extracted the data and assessed the risk of bias using the Newcastle-Ottawa Scale criteria. RESULTS: We initially identified 986 articles, or which seven were selected for review: two case-control studies, one cross-sectional studies and four cohort studies. Four studies reported data on drug consumption during pregnancy and four investigated drug use during the first year of life and the occurrence of enamel defects in primary dentition. CONCLUSIONS: There is no clear evidence that the use of drugs during pregnancy and during the first year of life is associated with HSPM. Further well-designed prospective studies are needed. CLINICAL RELEVANCE: Determining the etiological factors related to the development of HSPM would help to establish preventive protocols in patients at potential risk. As HSPM is predictive of molar incisor hypomineralisation (MIH), the application of preventive protocols would avoid complications in both the primary and permanent dentition.


Assuntos
Hipoplasia do Esmalte Dentário/etiologia , Exposição Materna/efeitos adversos , Dente Molar/patologia , Preparações Farmacêuticas , Dente Decíduo/patologia , Criança , Estudos Transversais , Feminino , Humanos , Gravidez , Prevalência , Estudos Prospectivos
13.
Acta Odontol Latinoam ; 33(3): 181-186, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33523082

RESUMO

Hypomineralized Second Primary Molars (HSPM) is the name used to describe the presence of demarcated enamel hypomineralization in second primary molars. HSPM has been compared with Molar Incisor Hypomineralization (MIH) as regards its clinical appearance and consequences. The aim of this study was to investigate associations between HSPM and dental caries in childhood. It was a cross-sectional populationbased study that included 216 children aged 4-6 years from public schools in Botelhos, Brazil. Children with all second primary molars erupted were eligible for participation. Clinical examination was performed by one calibrated examiner. HSPM was recorded according to modified European Academy of Paediatric Dentistry criteria. The main outcome was dental caries experience as indicated by the dmft index (%dmft>0) according to WHO criteria. Chi-square test and Logistic Regression Model were used to adjust the results for effects of covariates Among the 216 children examined, 22.2% presented HSPM. After adjustment for logistic regression, children with HSPM were found to have a 2.28 times greater chance of presenting dental caries. Our results reinforce the importance of HSPM in caries development in children, which should be considered by public health dentists in the process of planning actions aimed at this population.


Assuntos
Cárie Dentária/epidemiologia , Hipoplasia do Esmalte Dentário , Dente Molar/patologia , Saúde Bucal/estatística & dados numéricos , Brasil/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Esmalte Dentário/patologia , Hipoplasia do Esmalte Dentário/epidemiologia , Feminino , Humanos , Masculino , Prevalência
14.
Rio de Janeiro; s.n; 2020. 109 p. tab, ilus.
Tese em Português | BBO - Odontologia | ID: biblio-1150818

RESUMO

Trata-se de uma tese composta por quatro estudos, com o objetivo de avaliar possíveis fatores etiológicos (ambientais e genéticos) associados a presença de Hipomineralização Molar Incisivo (HMI) através de (a) : um estudo observacional transversal para verificar a prevalência de HMI na amostra estudada, junto com uma revisão bibliográfica da prevalência desta condição na população brasileira (objetivo-I); associação de fatores ambientais (durante o período gestacional e nos primeiros anos de vida) relacionados à presença de HMI e a influência destes fatores com a gravidade dessa condição (objetivo-II); associação dos polimorfismos de único nucletídeo (SNPs) localizados nos genes ameloblastina (AMBN), enamelina (ENAM) e calecreína com HMI, além da possível susceptibilidade dos SNPS com à cárie dentária (objetivo-III) e a interação entre fatores ambientais e as variações genéticas nos SNPs localizados nos genes fator 6 regulator de interferon (IRF6) e fator de crescimento transformador alfa (TGFα) estudados em amostras no Rio de Janeiro, Curitiba e turca (Istambul) (objetivo-IV). As coletas de dados do presente estudo foram realizadas em duas etapas: clínica e laboratorial. Os resultados encontrados foram: (I) uma alta heterogeneidade entre os estudos (Q = 52,81, p < 0.01, I2 = 98) com a prevalência final de HMI de 13.48% na população barasileira; (II) as intercorrências na gestação e o uso de medicamentos na primeira infância tiveram uma associação significativa com a presença de HMI (OR = 3,01; 95% CI = 1,74- 8,42; p= 0,014; OR = 3,55; 95% CI = 1,35-10,57; p = 0,019 ), entretanto esses fatores não influenciaram a gravidade dessa condição (p>0,05); (III) houve um resultado significativo no SNP rs2235091 localizado no gene KLK4 com a HMI (p<0,001), e os polimorfismos rs4694075 (AMBN) e rs3796704 (ENAM) mostraram associação com a cárie dentária (p<0.05); (IV) a amostra do Rio de Janeiro apresentou uma interação entre os SNPs rs1523305 (TGFα) e rs642961 (IRF6) (p = 0,03) e entre rs2073487 (IRF6) e rs2902345 (TGFα) (p = 0,04). Além disso, no estudo de Istambul houve uma associação entre o SNP rs930655 (TGFα) com todos os marcadores do gene IRF6 (p<0,05). Em relação ao uso de medicamentos nos primeiros anos de vida houve uma associação com os genes TGFα e IRF6 nas amostras de Curitiba e do Rio de Janeiro (p<0,05). Conclui-se que; (I) a prevalência de HMI é de 13.48% na população brasileira; (II) existe uma relação entre a presença de HMI com complicações que ocorrem durante a gestação (uso de medicamentos) e nos primeiros anos de vida da criança, entretanto esse fatores não influenciaram na gravidade dessa condição; (III) os genes que atuam na formação do esmalte são capazes de influenciar tanto no desenvolvimento da HMI como podem estar associados à cárie dentária e (IV) os polimorfismos localizados nos genes IRF6 e TGFα estão relacionados com o desenvolvimento da HMI. Além disso, o uso de medicamentos nos primeiros anos de vida podem potencializar o desenvolvimento da HMI. (AU)


It is a thesis composed of four studies, with the main to evaluate possible etiological factors (environmental and genetic variation) associated with the presence of MIH in the Brazilian population through (e); (objective-I); a cross-sectional observational study, with a bibliographic review of the prevalence of MIH in Brazil (objective-I); to determine of environmental factors (during in the pregany period and childhood) associated with the presence of MIH, and to evaluate the influence of these factors with the MIH severity (objective-II); associations of single nucleotide polymorphism (SNPs) presentin the genes ameloblastin (AMBN), enamelin (ENAM) and kalekrein (KLK-4) with MIH, in addition to the possible susceptibility of this genes to dental caries (objective-III); and interaction of environmetal factors and to determine the influence of genes interferon regulatory factor 6 (IRF6) and transforming growth factor alpha (TGFα) with MIH in a Brazilian (Rio de Janeiro e Curitiba) and Turkish (Istanbul) population (objective-IV). Data collections of the present study were carried out in two stages: clinical and laboratory.The results found were: (I) a high heterogeneity among the studies (Q = 52.81, p<0.01, I2 = 98) with a final prevalence of 13.48% na Brazilian population; (II) an association between intercurrences during pregnancy and child taking medications with the presence of MIH (OR = 3.55; 95% C.I = 1.35-10.57, p= 0.014; OR = 3.01; 95% C.I = 1.74- 8.42, p= 0.019, respectively), however these factors did not influence the severity of MIH (p>0.05); (III) there was an association between the variant alleles of polymorphisms rs2235091 in the KLK4 gene (p≤0.01) with the presence of MIH and the SNPs rs4694075 in AMBN and rs3796704 in ENAM presents association with dental caries (p<0.05); (IV) that the study from Rio de Janeiro showed a statistical evidence of interaction between TGFA rs1523305 and IRF6 rs642961 (p=0.03) and between genes IRF6 rs2073487 and TGFA rs2902345 (p=0.04). Significant results were found for the study from Istanbul between TGFα rs930655 and all IRF6 markers (p<0.05). Also, there was found statistical evidence for interaction of the SNPs in IRF6 and TGFα genes and medication taking from Curitiba and Rio de Janeiro studies (p<0.05). In summary; (I) the prevalence of MIH is 13.48% in the Brazilian population; (II) there is a relationship between complication that occur during pregnancy and in the child's first years of life with the presence of MIH, however these factors do not influence the severity of this condition; (III) the genes that acting in the enamel formation may influence the development of MIH and them, may be associated with dental caries; (IV) the polymorphisms located in the IRF6 and TGFα genes play a role in the development of MIH in different populations and that these genes may interacting with the medication taken in the first years of life, pontecialising the presence of MIH. (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Polimorfismo Genético , Variação Genética , Desmineralização do Dente/etiologia , Esmalte Dentário/patologia , Saúde Ambiental , Desmineralização do Dente/epidemiologia , Dente Molar/patologia
15.
Niger J Clin Pract ; 22(11): 1576-1582, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31719280

RESUMO

Aims: To evaluate the diagnostic abilities of near-infrared light transillumination (using the DIAGNOcam) and bitewing radiographs in detecting cavitated proximal carious lesions in primary molars. Subjects and Methods: The study was a cross-sectional analytical, clinical study. The proximal surfaces of primary molars of healthy 5- to 8-year-old children were radiographically screened for the presence of carious lesions in the enamel or outer third of dentin (D1). Two trained and calibrated examiners evaluated the depth of caries in bitewing radiographs and DIAGNOcam images and then verified the presence of cavitation by direct visual examination using the "International Caries Detection and Assessment System" after temporary tooth separation. Results: A total of 236 proximal lesions were included in the study. Most of the clinically cavitated lesions (51.9%) were D1 radiographically and in outer dentin lesions (scores 3 and 4) by the DIAGNOcam (37% and 48.1%, respectively). Although DIAGNOcam showed higher sensitivity (0.852) compared to the radiographs (0.519), it showed slightly less specificity (0.569) compared to the radiographs (0.579). However, DIAGNOcam showed higher value of the area under the curve (AUC = 0.722; P < 0.001) compared to the radiographic method (AUC = 0.561; P = 0.308). Conclusions: The DIAGNOcam showed higher sensitivity and better accuracy than bitewing radiographs in diagnosing cavitated proximal lesions in primary molars and can be generally considered as an alternative to radiographs to detect cavitation without the hazards of ionizing radiation in children.


Assuntos
Cárie Dentária/diagnóstico , Microrradiografia/instrumentação , Microrradiografia/métodos , Radiografia Interproximal/métodos , Radiografia Dentária/métodos , Dente Decíduo/diagnóstico por imagem , Transiluminação , Criança , Pré-Escolar , Estudos Transversais , Cárie Dentária/patologia , Esmalte Dentário/diagnóstico por imagem , Esmalte Dentário/patologia , Dentina/diagnóstico por imagem , Dentina/patologia , Feminino , Humanos , Masculino , Dente Molar/patologia , Radiografia Dentária Digital , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
16.
Medicine (Baltimore) ; 98(48): e18115, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31770237

RESUMO

INTRODUCTION: The aim of this report is to present a case of an apically involved tooth with successful regeneration by only applying enamel matrix derivative. The root of the tooth was planed and the defect area was well debrided using various instruments, including curettes and an ultrasonic scaler, and the root surface of the tooth and the defect area were loaded with enamel matrix derivative. PATIENT CONCERNS: A 32-year-old man visited the clinic due to a referral for the evaluation of his mandibular left first molar. DIAGNOSIS: The clinical and radiographic assessment displayed the loss of the periodontium around the tested tooth with apical involvement of the mesial root. Bleeding upon probing was noted at the mandibular first molar, with the deepest periodontal probing depth of 15 mm. INTERVENTIONS: A nonsurgical approach was firstly performed on the tooth, and the deepest probing depth was reduced to 12 mm. After re-evaluation, elevation of a full-thickness flap was done, the root of the tooth was planed, and the defect area was well debrided using various instruments, including curettes and an ultrasonic scaler. The defect area on the mandibular left first molar was grafted with enamel matrix derivative. OUTCOMES: The 7-month postoperative clinical and radiographic evaluation showed healthy gingiva and an increase in radiopacity. The final 1-year and 9-month postoperative evaluation showed that regeneration of bony defect was well maintained up to the final evaluation with reduction of probing depth. CONCLUSION: In conclusion, a case of apically involved tooth can be treated only with enamel matrix derivative after meticulous debridement with curettes and an ultrasonic scaler.


Assuntos
Produtos Biológicos/uso terapêutico , Matriz Óssea/transplante , Esmalte Dentário/transplante , Ápice Dentário/cirurgia , Doenças Dentárias/cirurgia , Adulto , Raspagem Dentária/métodos , Humanos , Masculino , Mandíbula/cirurgia , Dente Molar/patologia , Dente Molar/cirurgia , Periodonto/patologia , Periodonto/cirurgia , Ápice Dentário/patologia , Doenças Dentárias/patologia
17.
Medicine (Baltimore) ; 98(40): e17356, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577730

RESUMO

Molar-incisor malformation (MIM) is a recently defined dental abnormality of molar root and incisors, and introduced as one of the causes of periapical and periodontal abscess. The purpose of this study was to investigate the clinical and radiological features of MIM, with special emphasis on various medical history. A total of 38 patients with MIM were included in this study. Radiographic features and clinical data, including medical history, chief complaint, associated complications, treatment, and prognosis, were retrospectively investigated. On radiographs, the affected molars showed short, slender, underdeveloped roots and constricted pulp chambers. All affected incisors and canines exhibited dilacerated short roots, wedge-shaped defect on the cervical part of the crown. Complications included periodontal bone loss (52.6%), endodontic lesion (50.0%), and endodontic-periodontal lesion (28.9%). The medical histories of the patients with MIM indicate that almost all (94.7%) were hospitalized due to problems during the neonatal period. MIM may cause various dental problems, such as periapical and periodontal abscess and early loss of the affected teeth. The early diagnosis of MIM on radiographs and appropriate treatment will contribute to a favorable prognosis, especially for young and adolescent patients.


Assuntos
Incisivo/diagnóstico por imagem , Incisivo/patologia , Dente Molar/diagnóstico por imagem , Dente Molar/patologia , Anormalidades Dentárias/diagnóstico por imagem , Anormalidades Dentárias/patologia , Adolescente , Perda do Osso Alveolar/etiologia , Criança , Pré-Escolar , Cavidade Pulpar/diagnóstico por imagem , Cavidade Pulpar/patologia , Feminino , Humanos , Masculino , Radiografia Dentária , Estudos Retrospectivos , Anormalidades Dentárias/complicações , Anormalidades Dentárias/diagnóstico , Raiz Dentária/diagnóstico por imagem , Raiz Dentária/patologia , Adulto Jovem
18.
Am J Orthod Dentofacial Orthop ; 156(3): 355-364, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31474265

RESUMO

INTRODUCTION: The aim of this work was to analyze data of patients with failed or delayed eruption of first and second permanent molars, to assess the effectiveness of the treatment methods used. METHODS: Epidemiologic and clinical data of 125 patients (mean age 14.08 ± 4.04 years) with 197 affected molars (30 first and 167 second molars) were retrospectively analyzed. The treatment outcome was known in 161 molars after patient drop-out (20 patients with 36 molars). The cases were categorized into 8 groups according to the choice of treatment: orthodontic uprighting, surgical-orthodontic uprighting, surgical uprighting, surgical repositioning, surgical exposure, first or second molar extraction, third molar extraction, or removal of pathologic conditions. RESULTS: The overall treatment outcome was positive in 141 molars (87.6%). It was positive in all cases treated with orthodontic uprighting (7 molars), surgical exposure (10 molars), surgical uprighting (38 molars), and surgical repositioning (8 molars), but it was significantly lower for surgical-orthodontic uprighting (34/48 molars, 70.8%). The positive outcome was significantly lower for inclusion (52/68 molars, 76.5%) than for early-diagnosed condition (11/11 molars, 100%) and retention (78/82 molars, 95.1%), and for total bone crown coverage (21/28 molars, 75.0%) than for osteomucosal or mucosal crown coverage (120/133 molars, 90.2%). CONCLUSIONS: This study demonstrates that an early diagnosis results in a better outcome regardless of the treatment used, with the number of cases with a positive outcome being higher in younger patients.


Assuntos
Dente Molar/patologia , Anormalidades Dentárias , Erupção Dentária , Técnicas de Movimentação Dentária/métodos , Dente Impactado/terapia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Itália , Modelos Logísticos , Masculino , Dente Molar/cirurgia , Dente Serotino/cirurgia , Estudos Retrospectivos , Dente Impactado/diagnóstico , Dente Impactado/cirurgia , Resultado do Tratamento , Adulto Jovem
19.
J Ayub Med Coll Abbottabad ; 31(3): 418-421, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31535519

RESUMO

BACKGROUND: This study was conducted to compare the adaptation of resin-based sealants with that of Resin modified glass ionome-based sealants in various tooth fissure morphologies. METHODS: It was an in vitro experimental study done at the Dow University and NED University, Karachi, Pakistan. Ten extracted human molars were randomly assigned to two groups, (n=5) each. Fissure sealant material (Resin based sealant or resin modified glass ionomer-based sealant) was applied on the occlusal surface of the tooth according to manufacturer's recommendations. Specimens were thermocycled and then sectioned into three longitudinal parts in the bucco- lingual direction. Specimens were examined using scanning electron microscope for the adaptation of the sealant in the occlusal fissure. Mann-Whitney -U test and Kruskall-Wallis test were applied to compare the adaptability scores of sealant materials in the tooth fissure. Level of significance was kept at 0.05. RESULTS: There were no significant differences in the adaptability scores among U-shaped (p-value=0.35), V-shaped (p-value=0.89), IK-shaped (p-value=0.52), I-shaped (p-value- =0.41) and Y-shaped (p-value=1.00) fissure patterns. Similarly, there were no significant differences observed between the resin-based sealant (p-value=0.95) versus RMGIC based sealant (p-value=0.63) for the adaptability scores in various tooth fissure morphologies. CONCLUSIONS: No significant difference was found between resin-based sealants and resin modified glass ionomerbased sealants for the adaptation in various tooth fissure patterns.


Assuntos
Fissuras Dentárias/patologia , Cimentos de Ionômeros de Vidro , Dente Molar , Selantes de Fossas e Fissuras , Cimentos de Ionômeros de Vidro/química , Humanos , Dente Molar/efeitos dos fármacos , Dente Molar/patologia , Paquistão
20.
Int Orthod ; 17(4): 733-743, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31495755

RESUMO

AIM: The use of mini implants to create a passive intraoral anchorage point has been mainly tested in clinical trials. In this study, an experimental integrated approach evaluated mini implant loading protocols (immediate vs. delayed loading) on bone remodelling and mini implant stability and the consequent degree of dental intrusion and apical root resorption. METHODS: A total of 40 Absoanchor® mini implants with 1.2mm diameter and 8mm length were placed in a total of 5 minipigs, 8 per animal, 2 in each hemiarch. Each implant was attached through a lingual button to the vestibular side of the second and fourth premolars with a nitinol coil spring of 150g force. The analysis of morphological aspects included the degree of dental movement, mini implant stability, and new bone formation over the mini implant heads. Bone mini-implant interface and modifications of dental root in response to intrusion were studied by light and electron microscopy. RESULTS: The rate of mini implant success was>98%, mainly in those subjected to immediate loading. This loading protocol promoted a high degree of osseointegration along with a high degree of intrusive dental movement, particularly of the second premolars. However, the radiological and histological studies showed a low degree of root resorption. Associated with the high intrusive movement, the penetration of the root apexes produced an inner cortical surface deformation of the maxillary sinus floor by remodeling and bone growth. CONCLUSION: In minipigs immediate loading of smooth mini implants promoted a high degree of intrusive movement particularly of the second premolars, stimulated bone growth and osseointegration, but extensive root resorption was not observed.


Assuntos
Implantes Dentários , Dente Molar/patologia , Procedimentos de Ancoragem Ortodôntica , Osseointegração/fisiologia , Reabsorção da Raiz/patologia , Animais , Dente Pré-Molar , Remodelação Óssea , Implantes Dentários/efeitos adversos , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Modelos Animais , Procedimentos de Ancoragem Ortodôntica/efeitos adversos , Osteogênese , Reabsorção da Raiz/diagnóstico por imagem , Levantamento do Assoalho do Seio Maxilar , Suínos , Porco Miniatura , Técnicas de Movimentação Dentária
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