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1.
Braz. j. oral sci ; 20: e211322, jan.-dez. 2021. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1254256

RESUMO

Mood disorders such as stress and depression can promote alterations of several hormones Aim: The present study aimed to evaluate if symptoms of depression and stress are associated with halitosis. The hypothesis is that halitosis is associated with stress and depression symptoms. Methods: All university students' entrants in the Federal University of Pelotas (UFPel) were invited to participate. Self-reported halitosis was measured using a visual analog scale. Students were also asked about the presence of halitosis perceived by close individuals. The stress level was measured using a modified version of the Perceived Stress Scale and symptoms of depression were screened by Patient Health Questionnaire-2. Poisson Regression Models were performed. Results: Of a total of 2,058 students who participated in the study, only 16% of them have reported not having any degree of halitosis and 17.6% were informed of closed individuals having halitosis. After adjustments, stress and depression symptoms remained associated with halitosis selfreported. Individuals from the higher stressed quartile presented higher scores of halitosis (RR 1.37 CI95% [1.24­1.53]). Students who presented depressive symptoms showed higher scores of self-perceived halitosis (RR 1.20 CI95% [1.10­1.32]). When the association of stress and halitosis reported by close individuals was tested, symptoms of depression lost the association in the adjusted model, while individuals from the highest quartile from stress remained associated (PR 1.36 CI95% [1.02­1.81]). Conclusion: Halitosis was associated with stress even after control for oral health and socioeconomic variables


Assuntos
Humanos , Masculino , Feminino , Estresse Psicológico , Depressão , Halitose
2.
Nurs Open ; 8(3): 1030-1037, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482659

RESUMO

AIM: This study aimed to examine the sleep pattern of breast cancer survivors and anxiety and depression associated with sleep quality to provide evidence-based information for the development of interventions to improve sleep disorders in these survivors. DESIGN: A cross-sectional study. METHODS: The subjects were 266 breast cancer survivors in South Korea. Structured questionnaires regarding sleep quality, anxiety and depression were used. The data were analysed using t test, ANOVA and multiple regression analysis. RESULTS: Sleep duration and sleep disturbance were found to affect anxiety, whereas sleep latency and subjective sleep quality were found to affect depression. These results suggest that various factors affecting sleep quality should be considered when providing care for anxiety and depression in breast cancer survivors.


Assuntos
Neoplasias da Mama , Sobreviventes de Câncer , Ansiedade/epidemiologia , Neoplasias da Mama/complicações , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , República da Coreia/epidemiologia , Sono , Sobreviventes
3.
BMC Med Educ ; 21(1): 471, 2021 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482821

RESUMO

BACKGROUND: Psychological disorders have negative consequences on students' learning and academic performance. In addition, academic burnout is one of the common challenges that affects students' motivation and academic eagerness; however, the determinant is not clear. Medical students, meanwhile, demand special attention due to their professional responsibilities. In this regard, this study is conducted to investigate the academic burnout, rate of depression, anxiety and stress as well as related factors among undergraduate medical students at the Tehran Medical Sciences Islamic Azad University. METHODS: This cross-sectional and descriptive study was performed on medical students of Islamic Azad University of Tehran in 2017. In phase I, conducted on all stager students, Maslach Burnout questionnaire was used. In phase II, the DASS-42 questionnaire was provided for 123 students, 120 of whom met the inclusion criteria. In addition, another questionnaire including gender, age, lifestyle, marital and financial status, nutrition style, vitamin D deficiency, smoking, study hours per week, work efficiency and distance from the place of residence to the teaching hospital was used. Finally, the data extracted by SPSS version 23 was analyzed at the significance level of 0.05. RESULTS: In phase I of the study, 17 subjects showed academic burnout (16.3%). Out of all, 76.5% of students with academic burnout did not focus on the study and students' academic burnout was associated with a decrease in their focus (P < 0.05). However, the relationship between academic burnout and other factors was not significant. In phase II, the prevalence of depression, anxiety and stress was 37.5, 41.1 and 30.3%, respectively. The prevalence of severe and very severe degrees that required psychiatric follow-up were 10.5, 10.5 and 7% for depression, anxiety and stress, respectively. According to statistical analyzes, there is a significant direct relationship between anxiety and the distance from the place of residence to the teaching hospital (P = 0.040). CONCLUSION: The present study estimated the prevalence of academic burnout to be between 9.2 and 23.4%, considering the 5% error in the calculation, and the level of anxiety was related to the distance from the place of residence to the hospital.


Assuntos
Esgotamento Profissional , Estudantes de Medicina , Ansiedade/epidemiologia , Esgotamento Profissional/epidemiologia , Esgotamento Psicológico/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Humanos , Irã (Geográfico)/epidemiologia , Prevalência , Inquéritos e Questionários , Universidades
4.
Front Public Health ; 9: 697642, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34485228

RESUMO

Background: The novel 2019 coronavirus disease (COVID-19) pandemic has spread rapidly worldwide and poses a global health threat. Aims: This study assessed the prevalence of anxiety and depression symptoms in Chinese students during the COVID-19 pandemic and explored potential moderating factors. Methods: We searched English and Chinese databases using pertinent keywords for articles published and unpublished, up until November 2020. The estimate of the overall prevalence of anxiety and depression was conducted through a random-effects model. Results: A total of 31 cross-sectional studies were included. The overall prevalence of anxiety and depression symptoms in Chinese students during the COVID-19 pandemic was 24.0% (95% CI [20.0-29.0%]) and 22.0% (95% CI [18.0-27.0%]) respectively. Subgroup analyses revealed that Chinese middle school students were at heightened risk of anxiety, while university students were at heightened risk of depression. Students who lived in higher-risk areas presented severe anxiety and depression, especially during the late period of the COVID-19 epidemic. Conclusions: Overall, during the COVID-19 pandemic, there was a high prevalence of anxiety in Chinese students and a high prevalence of depression among Chinese students in high-risk areas. Therefore, comprehensive and targeted psychological interventions should be developed to address the mental health of students in different grades, especially in high-risk areas and during the late period of the COVID-19 pandemic.


Assuntos
COVID-19 , Pandemias , Ansiedade/epidemiologia , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Humanos , SARS-CoV-2 , Estudantes
5.
Artigo em Russo | MEDLINE | ID: mdl-34486846

RESUMO

The article considers various mental reactions of psychiatrists and narcologists against the background of the SARS-CoV-2 pandemic, based on a brief scientific analysis of publications and experimental psychological research methods. The purpose of study was to identify impact of the COVID-19 pandemic on mental health of psychiatrists and psychiatrists-narcologists. The results of survey of psychiatrists and narcologists are presented. The study was carried out using such test techniques as life quality scale SF-36 (Health Status Survey), Lazarus questionnaire "Coping Behaviors" adjusted to conditions of Russia and Hamilton scales to assess depression and anxiety (HDRS, HARS). The results.The low level of psychological well-being, moderate degree of preference for all coping strategies were established. The anxiety was determine in 34.8% of respondents and depression in 8.7%. It was established that actually, the impact of the COVID-19 pandemic on medical workers is conditioned by complex of mental reactions (from anosognosia to expressed anxiety and depressive disorders) and is accompanied by increasing general anxiety.


Assuntos
COVID-19 , Pessoal de Saúde/psicologia , Estresse Psicológico , COVID-19/psicologia , Depressão/epidemiologia , Humanos , Pandemias , Psiquiatria
6.
Artigo em Chinês | MEDLINE | ID: mdl-34488263

RESUMO

Objective: To explore the occurrence level of depressive symptoms and it's influencing factors among gas field workers. Methods: In October 2018, a cross-sectional study was conducted in 1726 gas field workers from a gas field by using cluster sampling method. Questionaire was used to evaluate the individual factors, depressive symptoms, occupational stress factors and stress regulatory factors. The correlation between depressive symptoms and occupational stress was analyzed. Multivariate logistic regression was used to analyze the influencing factors of depressive symptoms. Results: The depressive symptoms score of gas field workers was 12.00 (7.00, 19.00) point. Correlation analysis revealed that depressive symptoms score was positively related to sleep disorders (r=0.598) , effort (r=0.186) , daily tension (r=0.478) , negative affectivity (r=0.565) , social support (r=0.446) and monotony of work (r=0.484) (P<0.01) . And it was negatively related to reward (r=-0.386) , work stability (r=-0.294) , promotion opportunities (r=-0.258) , positive affectivity (r= -0.310) , self-efficacy (r=-0.312) , contral strategy (r=-0.268) , support strategy (r=-0.209) and job satisfaction (r=-0.398) (P<0.01) . Multivariate logistic regression analysis revealed that sleep disorder, high negative affectivity, low support from colleagues, low support from family, high monotony of work and high daily tension were the risk factors for depressive symptoms of gas field worker (OR=3.423, 95%CI: 2.644-4.397; OR=2.847, 95%CI: 2.200-3.683; OR=1.646, 95%CI: 1.215-2.116; OR=1.496, 95%CI: 1.164-1.923; OR=1.578, 95%CI: 1.227-2.303; OR=1.903, 95%CI: 1.480-2.440; P<0.01) . High work stability, high self-efficacy and high job satisfaction were protective factors for depressive symptoms of gas field workers (OR=0.752, 95%CI: 0.591-0.958; OR=0.590, 95%CI: 0.465-0.749; OR=0.718, 95%CI: 0.516-0.999; P<0.05) . Conclusion: Occupational stress factors have a great influence on the depressive symptoms of gas field workers. Increased work stability, self-efficacy and job satisfaction could reduce the risk of depressive symptoms.


Assuntos
Depressão , Estresse Ocupacional , Estudos Transversais , Depressão/epidemiologia , Humanos , Satisfação no Emprego , Estresse Ocupacional/epidemiologia , Campos de Petróleo e Gás , Estresse Psicológico , Inquéritos e Questionários
7.
JNMA J Nepal Med Assoc ; 59(235): 239-242, 2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-34506442

RESUMO

INTRODUCTION: Health personnel working in the frontline to deal with COVID 19 outbreak are at increased risk of developing psychological problems. This study aims to find out the prevalence of depression, anxiety and stress among Nepalese health care workers. METHODS: This is a hospital based descriptive cross-sectional study conducted from July 10 2020 to September 10, 2020. All health care workers (total 280) were included in the study. HADS-14 item was used to measure anxiety and depression. Perceived stress scale was used to measure stress. Data was analyzed with Statistical Package for the Social Sciences software version 24.0. Statistical data was analyzed by percentage, mean and standard deviation. RESULTS: Out of total 270 respondents the prevalence of anxiety, depression and stress was found to be 112 (41.4%), 65 (24.1%) and 203 (74%) respectively. Females accounted for 148 (54.8%) and males 122 (45.2%). More than one third 96 (35.6%) of the health workers were working in front line. CONCLUSIONS: Prevalence of anxiety, depression and stress is higher among health workers when compared to similar studies. Effective strategies toward improving the mental health like adequate rest, supply of protective equipments, frequent breaks, ensuring safety issues of their family members, training on management of stress might be helpful in reducing stress.


Assuntos
COVID-19 , Pandemias , Ansiedade/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Feminino , Pessoal de Saúde , Humanos , Masculino , Nepal/epidemiologia , SARS-CoV-2 , Centros de Atenção Terciária
8.
JNMA J Nepal Med Assoc ; 59(234): 160-164, 2021 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-34506466

RESUMO

INTRODUCTION: Health care workers experienced considerable psychological distress as a result of COVID-19 due to providing direct patient care, quarantine or self-isolation, and lockdown experience. They are front line workers handling the patients and are at greater risk than others. This study aims to determine the socio-psychological impact of COVID-19 pandemic among healthcare workers of a medical college in Nepal. METHODS: A descriptive cross-sectional study from different institutions of the Nepalese Army Institute of Health Sciences from May 2020 to July 2020 was conducted. Ethical approval was taken from the Institutional Review Committee, Nepalese Army Institute of Health Sciences. A total of 212 responses were collected through Google form along with the Depression, anxiety, stress and scale-21 to assess the level of Depression, Anxiety, and Stress. Analysis of the data was done using Statistical Package of Social Sciences version 22. RESULTS: Respondents with extremely severe depression, anxiety, and stress was found to be 16 (7.5%), 24 (11.3%), and 4 (1.95%) respectively. Most of the respondents do not have travel history, but 6 (2.8%) and 28 (13.2%) have direct and indirect contact respectively with the COVID patients. Daily activities such as food intake, the workload at home, and relationships with family members were increased. 208 (98%) have followed preventive measures such as mouth mask, hand washes, and physical distance. CONCLUSIONS: COVID-19 pandemic has imposed a significant level of depression, anxiety, and stress on health care workers caring for infected patients, with their main concern being the risk of transmitting the infection to their families or acquiring it themselves.


Assuntos
COVID-19 , Pandemias , Ansiedade/epidemiologia , Controle de Doenças Transmissíveis , Estudos Transversais , Depressão/epidemiologia , Pessoal de Saúde , Humanos , Nepal/epidemiologia , SARS-CoV-2 , Inquéritos e Questionários
9.
JNMA J Nepal Med Assoc ; 59(234): 152-155, 2021 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-34506472

RESUMO

INTRODUCTION: COVID-19 is a beta coronavirus that is transmitted by physical interaction or close contact. This Coronavirus Pandemic has also created stress and anxiety among pregnant women all over the world. The disease was first identified in Wuhan city, China, in late December 2019 and was declared pandemic by the World Health Organization on 11th March 2020. Concern and stress in pregnancy are associated with pre-eclampsia, intrauterine growth restriction, preterm labour, depression etc. Pregnancy is an immune-compromised state and poses a high risk to this risk. This study aims to identify anxiety about the coronavirus infection among pregnant women visiting a tertiary care centre in Kathmandu, Nepal, during this COVID-19 pandemic. METHODS: This is a descriptive cross-sectional study conducted at Kathmandu Medical College and Teaching Hospital from 15th July 2020 to 30th July 2020 after taking the ethical clearance from the Institutional Review Committee of Kathmandu Medical College (reference no. 207202002). Convenient sampling method was used. All the data were entered in Statistical Package for the Social Sciences data 20.0 and analyzed. Data was presented in frequencies, charts and percentage. RESULTS: Among the total 273 cases, only 2 (0.73%) cases had a score between 25-30 corresponding to moderate to severe anxiety, 21 (7.69%) had a score between 18-24, which corresponds to mild to moderate anxiety and 250 (91.57%) had score 0-17 which corresponds mild status. CONCLUSIONS: Most of the participants in the study reported a mild status of anxiety. Very few participants reported moderate to severe anxiety.


Assuntos
COVID-19 , Pandemias , Ansiedade/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Recém-Nascido , Nepal/epidemiologia , Gravidez , Gestantes , SARS-CoV-2 , Centros de Atenção Terciária
10.
JNMA J Nepal Med Assoc ; 59(238): 580-584, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34508398

RESUMO

INTRODUCTION: Studies among health care workers from different part of world during the coronavirus disease 19 pandemic have reported substantial impact on their physical, mental and emotional well-being. This study measured the impact of coronavirus disease 2019 on the mental health of Nepali healthcare workers in different parts of the world during the pandemic. METHODS: This cross-sectional survey was carried out from December 25, 2020 to Jan 25, 2021. Ethical approval was taken from the Institutional Review Committee (reference number: 372). Online questionnaire including demographic profiles and Depression, Anxiety, and Stress Scales-21 instrument were sent to Nepali healthcare workers around the world through social media apps using convenience sampling. Data were entered into Microsoft Excel for Mac version 16.49 and analysed. RESULTS: Among 208 who participated in the study, 62 (30%) participants were positive for anxiety, 47 (22.5%) for depression and 25 (12%) for stress. Higher prevalence of depression 18 (30%) and stress 10 (17%) was found in nurses compared to paramedics, among whom depression was seen in 5 (20%) and stress in 4 (16%). Among doctors, depression was found in 24 (19%) and stress in 11 (9%). CONCLUSIONS: This study demonstrated that a high proportion of healthcare workers were suffering from depression, anxiety and stress. Our findings are similar to the data from other national and international studies.


Assuntos
COVID-19 , Pandemias , Ansiedade/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Pessoal de Saúde , Humanos , SARS-CoV-2 , Estresse Psicológico/epidemiologia
11.
JNMA J Nepal Med Assoc ; 59(240): 787-790, 2021 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-34508468

RESUMO

INTRODUCTION: Alcohol dependence syndrome is an important and major public health issue seen in our community and health center. It is mostly associated with different mental health problems and psychiatric co-morbidities. This study aims to find out the prevalence of depression among alcohol dependence syndrome in a tertiary care hospital. METHODS: A descriptive cross-sectional study was conducted over one year from April 15, 2020, to February 15, 2021 at a tertiary care hospital. The ethical approval was obtained from the Institutional Review Committee of Nobel Medical College (reference number: 409/2020). Convenience sampling method was used. The patients admitted for alcohol use and related problems in the Psychiatry Department, Nobel Medical College Teaching Hospital, Biratnagar were included. Data entry was done using Microsoft Excel and statistical analysis was done by using Statistical Packages of Social Sciences Version 16.0. Point estimate at 95% Confidence Interval was calculated along with frequency and percentage. RESULTS: The prevalence of depression in patients with Alcohol Dependence Syndrome was 17 (16.3%) (95% Confidence Interval= 9.20-23.39) . The patients suffering from depressive disorder male and female were 16 (94.1%) and 1 (5.8%) respectively. The participants with Alcohol Dependence Syndrome with no other comorbid psychiatric disorders were found to be 60 (57.7%). CONCLUSIONS: Psychiatric comorbidity was found to be common in alcohol dependent people among which depression was found to be most common.


Assuntos
Alcoolismo , Alcoolismo/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Centros de Atenção Terciária
12.
JNMA J Nepal Med Assoc ; 59(239): 645-648, 2021 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-34508516

RESUMO

INTRODUCTION: Depression is a common mental disorder. Medical school is a stressful environment. The outbreak of COVID-19 has added to the plight of medical students. This study was conducted to determine the prevalence of depression among medical students of a medical college in Nepal during the COVID-19 pandemic. METHODS: A descriptive cross-sectional study was conducted among medical students of a medical college in Nepal from August 2020 to September 2020. The sample size of our study was 223. A convenient sampling method was adopted for the selection of respondents. The study was approved by the Institutional Review Committee (Reference no:321). The data were analyzed using Statistical Package for Social Sciences version 22. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. The study instrument consisted of the Patient Health Questionnaire and socio-demographic information. RESULTS: Out of 223 participants, the prevalence of depression was seen among 52 (23.3%) (17.7%-28.9% at 95% Confidence Interval) students in our study. Among them, 25 (48.1%) females and 27 (51.9%) males were depressed. The prevalence of depression was higher in preclinical years (first and second year) than in clinical years (third, fourth and final year). CONCLUSIONS: The prevalence of depression among medical students in Nepal during the pandemic was less than the findings of similar studies conducted in Nepal before the pandemic. Further studies are required to get more knowledge about the factors associated with mental health of medical students.


Assuntos
COVID-19 , Estudantes de Medicina , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Masculino , Nepal/epidemiologia , Pandemias , SARS-CoV-2
13.
JNMA J Nepal Med Assoc ; 59(236): 346-349, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-34508520

RESUMO

INTRODUCTION: Medical students are prone to develop stress, anxiety and depression owing to vastness of curriculum, hectic lifestyle, economic burden, and competitiveness of medical field. The study aims to find out the prevalence of depression, anxiety, and stress among first-year medical students. METHODS: A descriptive cross-sectional study was conducted among 91 first-year students of Bachelor of Medicine and Bachelor of Surgery enrolled in a tertiary care hospital using depression, anxiety, and stress-42 scale along with a questionnaire regarding sociodemographic and stressors for their problems. Whole sampling was done and the study was conducted between June and July 2018 after taking ethical approval from the Research and Institutional Review Committee (Reference Number: 57-074/075). RESULTS: The highest prevalence among undergraduate medical students was found to be anxiety 54 (59.3%), followed by stress 41 (45.1%) and depression 40 (44%). CONCLUSIONS: Almost half of the first-year medical students reported some level of depression, anxiety, or stress. It is important to implement programs in the early years of the medical school from the administrative level to help and identify students suffering from depression, anxiety, and stress.


Assuntos
Estudantes de Medicina , Ansiedade/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Humanos , Centros de Atenção Terciária
14.
BMC Public Health ; 21(1): 1617, 2021 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482826

RESUMO

BACKGROUND: Although pain has been identified as an important public health problem among adolescents, few studies have investigated possible protective and risk factors for pain. The main aim of the present study was to investigate associations between prevalence of daily pain, self-efficacy, sleep duration, and symptoms of depression in a representative sample of Norwegian adolescents. METHODS: A comprehensive cross-sectional survey was completed by 12,867 junior high school students and high school students (response rate: 90%) aged 14-19 years. Logistic regression models were adjusted for age, gender, and parental educational level. RESULTS: We found a high prevalence of daily pain among adolescents, especially among girls (19%) compared with boys (7%). Short sleep duration was associated with increased odds ratios (ORs) of pain in the shoulders/neck (OR 1.3; 95% CI 1.3-2.0) and stomach (1.7; 1.2-2.4). Symptoms of depression were associated with increased ORs for all measured types of daily pain, including head (3.7; 3.0-4.6), shoulders/neck (3.9; 3.1-4.8), joints/muscles (4.3; 3.3-5.6), and stomach (5.5; 4.1-7.4). By contrast, self-efficacy was not associated with any form of daily pain. CONCLUSION: Given the burden of pain, high incidence of pain problems, and strong association between pain and depression and, to some degree, short sleep duration, co-occurring symptoms may be an important area for research in the public health field. The results highlight the importance of early identification and prevention. Longitudinal studies are needed to understand better pain problems and their underlying mechanisms with the aim of developing targeted interventions.


Assuntos
Depressão , Autoeficácia , Adolescente , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Masculino , Dor , Sono , Inquéritos e Questionários
15.
Zhongguo Zhong Yao Za Zhi ; 46(16): 4230-4237, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34467737

RESUMO

This study aimed to explore the mechanism of Xiaoyao San(XYS) in the treatment of three diseases of liver depression and spleen deficiency, ie, depression, breast hyperplasia, and functional dyspepsia, and to provide a theoretical basis for the interpretation of the scientific connotation of "treating different diseases with the same method" of traditional Chinese medicines. Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to screen the active components of XYS which underwent principal component analysis(PCA) with the available drugs for these three diseases to determine the corresponding biological activities. The targets of XYS on depression, breast hyperplasia, and functional dyspepsia were obtained from GeneCards, TTD, CTD, and DrugBank databases. Cytoscape was used to plot the "individual herbal medicine-active components-potential targets" network. The resulting key targets were subjected to Kyoto encyclopedia of genes and genomes(KEGG) pathway analysis and gene ontology(GO) enrichment analysis. A total of 121 active components of XYS and 38 common targets in the treatment of depression, breast hyperplasia, and functional dyspepsia were collected. The key biological pathways were identified, including advanced glycation and products(AGEs)-receptor for advanced glycation and products(RAGE) signaling pathway in diabetic complications, HIF-1 signaling pathway, and cancer-related pathways. The key targets of XYS in the treatment of depression, breast hyperplasia, and functional dyspepsia included IL6, IL4, and TNF, and the key components were kaempferol, quercetin, aloe-emodin, etc. As revealed by the molecular docking, a strong affinity was observed between the key components and the key targets, which confirmed the results. The therapeutic efficacy of XYS in the treatment of diseases of liver depression and spleen deficiency was presumedly achieved by reducing the inflammatory reactions. The current findings are expected to provide novel research ideas and approaches to classify the scientific connotation of "treating different diseases with the same method" of Chinese medicines, as well as a theoretical basis for understanding the mechanism of XYS and exploring its clinical applications.


Assuntos
Medicamentos de Ervas Chinesas , Dispepsia , Depressão/tratamento farmacológico , Medicamentos de Ervas Chinesas/farmacologia , Dispepsia/tratamento farmacológico , Humanos , Hiperplasia/tratamento farmacológico , Medicina Tradicional Chinesa , Simulação de Acoplamento Molecular
16.
BMC Psychol ; 9(1): 130, 2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34465377

RESUMO

BACKGROUND: Symptoms of depression and anxiety are common in adults with cardiovascular diseases (CVDs) and diabetes mellitus (DM). The literature on depression and anxiety in CVDs and DM populations is extensive; however, studies examining these relationships over time, directly compared to adults without these conditions, are still lacking. This study aimed to investigate trends in depression and anxiety symptom prevalence over more than 20 years in adults with CVDs and DM compared to the general population. METHODS: We used data from the population-based Trøndelag Health Study (HUNT), Norway, including adults (≥ 20 years) from three waves; the HUNT2 (1995-97; n = 65,228), HUNT3 (2006-08; n = 50,800) and HUNT4 (2017-19; n = 56,042). Depressive and anxiety symptom prevalence was measured independently by the Hospital Anxiety and Depressions scale (HADS) in sex-stratified samples. We analyzed associations of these common psychological symptoms with CVDs and DM over time using multi-level random-effects models, accounting for repeated measurements and individual variation. RESULTS: Overall, the CVDs groups reported higher levels of depression than those free of CVDs in all waves of the study. Further, depressive and anxiety symptom prevalence in adults with and without CVDs and DM declined from HUNT2 to HUNT4, whereas women reported more anxiety than men. Positive associations of depression and anxiety symptoms with CVDs and DM in HUNT2 declined over time. However, associations of CVDs with depression symptoms remained over time in men. Moreover, in women, DM was associated with increased depression symptom risk in HUNT2 and HUNT4. CONCLUSIONS: Depression and anxiety symptoms are frequent in adults with CVDs. Further, our time trend analysis indicates that anxiety and depression are differentially related to CVDs and DM and sex. This study highlights the importance of awareness and management of psychological symptoms in CVDs and DM populations.


Assuntos
Doenças Cardiovasculares , Diabetes Mellitus , Adulto , Ansiedade/epidemiologia , Doenças Cardiovasculares/epidemiologia , Depressão/epidemiologia , Diabetes Mellitus/epidemiologia , Feminino , Humanos , Masculino , Noruega/epidemiologia , Prevalência
17.
Rev Assoc Med Bras (1992) ; 67(3): 462-467, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34468615

RESUMO

Dry eye disease (DED) is a multifactorial disease affecting tear quality and/or production and eye surface and is one of the most common eye disorders found in clinical practice. The association between psychiatric disorders and dry eye has been the subject of several studies since patients with this syndrome present a tendency toward a depressive mood. This narrative review aims to demonstrate the relationship between depression and DED, which is due to the side effects of psychotropic drugs or the tendency of the low pain threshold of the depressive patient. The work was produced from the analysis of 13 articles published during the last decade on this subject and demonstrated that the depressive state is linked to the appearance or worsening of DED resulting from chronic eye pain. Also, the treatment of depression with selective inhibitors of serotonin receptors causes inflammatory cytokine secretion with subsequent inflammation and apoptosis of cells on the ocular surface. The need for new studies on optimization of psychiatric treatment in patients with ophthalmic diseases, such as DED, was verified, aiming at the relief of symptoms and the reduction of psychological and eye damage caused by them.


Assuntos
Dor Crônica , Síndromes do Olho Seco , Transtornos Mentais , Depressão/tratamento farmacológico , Síndromes do Olho Seco/tratamento farmacológico , Humanos , Lágrimas
18.
J Assoc Physicians India ; 69(4): 11-12, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34470190

RESUMO

AIMS: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by impaired gut-brain interaction. Considering the paucity of evidence in the Indian setting, the current study was conducted to determine the sociodemographics, clinical profiles, management practices, and patients' perception among newly diagnosed patients with IBS. METHODS: This was a cross-sectional, single-visit, observational, non-interventional, epidemiological study conducted across 12 centres. The primary objective was evaluation of sociodemographic and clinical profiles. The key secondary objective was assessment of gastrointestinal symptom severity including evaluation of anxiety and depression using the hospital anxiety and depression scale (HADS) scores. Knowledge, attitude, and practices (KAP) were evaluated as an exploratory objective. RESULTS: Out of 300 enrolled patients, 120 (40%) were aged 31-45 years (mean age: 38.55±12.45 years), and 204 were men (68%). Overall, 40% of patients belonged to the upper-middle-class, with a Kuppuswamy score of 16-25. Most patients (91%) did not work in night shifts. Only 13% of patients performed more than recommended physical activity. Stress and food were the leading triggers for IBS (29%). Abdominal pain and diarrhoea as cardinal symptoms were reported by 43.3% and 33.0% patients, respectively. Borderline abnormal anxiety and depression were reported by 21.3% and 26.7% of patients, respectively. KAP assessment revealed that 56.0% of patients had poor knowledge, 26.3% had moderate knowledge, and 17.7% had good knowledge about IBS; nevertheless, 43% of patients maintained high levels of precaution towards managing symptoms. CONCLUSION: Given the limited knowledge about IBS in India among newly diagnosed patients, strategies to enhance awareness about the condition are warranted.


Assuntos
Síndrome do Intestino Irritável , Adulto , Ansiedade/epidemiologia , Ansiedade/etiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Humanos , Índia/epidemiologia , Síndrome do Intestino Irritável/epidemiologia , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Índice de Gravidade de Doença , Inquéritos e Questionários
19.
Rev Assoc Med Bras (1992) ; 67(4): 516-521, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34495054

RESUMO

OBJECTIVE: The aim was to study the prevalence of symptoms of anxiety and post-traumatic stress in a sample of Brazilians and their relationship with sex, age, and work situation, and compare if these symptoms change with 8 weeks of quarantine. METHODS: Online survey to collect epidemiological data and apply the Beck Anxiety Inventory (BAI) and Impact of Event Scale-Revised (IES-R). Eight weeks later, the researchers requested the same requirements to complete the BAI and IES-R and compare the results. RESULTS: The sample of 287 answered the first and second questionnaires, being 72.8% women, with a median age of 22 years. In the first interview, the median BAI was 12 (7-19) and the median IES-R was 27.0 (15-40); in the second, the median BAI was 11 (6-22) and the IES-R was 30 (15-41) with p<00001 and 0.09, respectively. Anxiety levels were worse in females (p<0.0001 for both BAI and IES-R) and in those who worked/studied in the area of health (p=0.001 for BAI and 0.01 for IES-R). There was a negative correlation between age and anxiety (p<0.0001 for BAI and IES-R). CONCLUSIONS: A high prevalence of anxiety that lowered after 8 weeks were found. Anxiety was worse in females, in younger people, and in those who worked/studied in the area of health.


Assuntos
COVID-19 , Transtornos de Estresse Pós-Traumáticos , Adulto , Ansiedade/epidemiologia , Depressão , Feminino , Humanos , Estudos Longitudinais , Masculino , Pandemias , SARS-CoV-2 , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Inquéritos e Questionários , Adulto Jovem
20.
Rev Assoc Med Bras (1992) ; 67(4): 571-576, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34495063

RESUMO

OBJECTIVE: The goals of this study are to compare self-reported depression and anxiety in subjects diagnosed of asthma and healthy controls. METHODS: We designed a case-control study. Subjects were recruited using a consecutive sampling method from a single institution. Two groups were created: Asthma and healthy controls. Data of medical history and demographic background were collected from the medical record. Self-reported depression level was assessed using Beck's depression inventory (BDI). Self-reported anxiety was measured with the "State-trait anxiety inventory" (STAI). RESULTS: Fifty-one subjects with asthma, and fifty healthy patients were included in this study. BDI scores (p<0.001) were higher for asthma (10.22±7.3) than in the control group (5.2±6.56). STAI state (p<0.001) was higher in asthma (42.61±11.5) than in controls (34.88±9.25). STAI trait (p<0.001) showed higher scores in asthma (43.14±10.89) than in controls (34.62±9.19). CONCLUSIONS: These study findings showed that BDI, and STAI trait and state scores are significantly higher in subjects who suffer from asthma than healthy controls.


Assuntos
Asma , Depressão , Ansiedade , Transtornos de Ansiedade , Estudos de Casos e Controles , Humanos
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