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1.
Pan Afr Med J ; 39: 94, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34466196

RESUMO

Introduction: different studies have shown a relationship between depression and nutrition, but there seems to be no consistent consensus on this. This study therefore investigated the relationship of nutrition status and depression among workers in tertiary educational institutions in Southwestern Nigeria. Methods: this was a cross-sectional study conducted among 399 members of staff of three tertiary educational institutions in Osun State, Southwestern Nigeria. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), while nutritional status was assessed using the body mass index (BMI), waist circumference and waist hip ratio (WHR). The respondents were selected using multi-stage sampling technique, and data were collected using pre-tested structured questionnaires. Analysis was done using IBM SPSS. Results: the mean age of the respondents was 45.8 ± 10.4 years. The prevalence of depression was 23.8%. Concerning the nutritional status of respondents, 2.3% were underweight and 69.7% were overweight/obese. There were statistically significant associations between depression and the nutritional status of the respondents using BMI (p = 0.001), WHR (p = 0.015) and waist circumference (p = 0.036). After controlling for other factors, only the BMI was still significantly associated with depression, such that those underweight were more likely to be depressed (Odds ratio: 7.9; p-value: 0.009). Conclusion: the prevalence of depression among the respondents was relatively high, and this was significantly associated with the BMI, even after controlling for co-founders.


Assuntos
Depressão/epidemiologia , Estado Nutricional , Magreza/complicações , Adulto , Índice de Massa Corporal , Estudos Transversais , Depressão/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria/epidemiologia , Obesidade/complicações , Obesidade/epidemiologia , Sobrepeso/complicações , Sobrepeso/epidemiologia , Prevalência , Inquéritos e Questionários , Magreza/epidemiologia , Relação Cintura-Quadril
2.
J Assoc Physicians India ; 69(4): 11-12, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34470190

RESUMO

AIMS: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by impaired gut-brain interaction. Considering the paucity of evidence in the Indian setting, the current study was conducted to determine the sociodemographics, clinical profiles, management practices, and patients' perception among newly diagnosed patients with IBS. METHODS: This was a cross-sectional, single-visit, observational, non-interventional, epidemiological study conducted across 12 centres. The primary objective was evaluation of sociodemographic and clinical profiles. The key secondary objective was assessment of gastrointestinal symptom severity including evaluation of anxiety and depression using the hospital anxiety and depression scale (HADS) scores. Knowledge, attitude, and practices (KAP) were evaluated as an exploratory objective. RESULTS: Out of 300 enrolled patients, 120 (40%) were aged 31-45 years (mean age: 38.55±12.45 years), and 204 were men (68%). Overall, 40% of patients belonged to the upper-middle-class, with a Kuppuswamy score of 16-25. Most patients (91%) did not work in night shifts. Only 13% of patients performed more than recommended physical activity. Stress and food were the leading triggers for IBS (29%). Abdominal pain and diarrhoea as cardinal symptoms were reported by 43.3% and 33.0% patients, respectively. Borderline abnormal anxiety and depression were reported by 21.3% and 26.7% of patients, respectively. KAP assessment revealed that 56.0% of patients had poor knowledge, 26.3% had moderate knowledge, and 17.7% had good knowledge about IBS; nevertheless, 43% of patients maintained high levels of precaution towards managing symptoms. CONCLUSION: Given the limited knowledge about IBS in India among newly diagnosed patients, strategies to enhance awareness about the condition are warranted.


Assuntos
Síndrome do Intestino Irritável , Adulto , Ansiedade/epidemiologia , Ansiedade/etiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Humanos , Índia/epidemiologia , Síndrome do Intestino Irritável/epidemiologia , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Índice de Gravidade de Doença , Inquéritos e Questionários
3.
Rev Lat Am Enfermagem ; 29: e3480, 2021.
Artigo em Inglês, Português, Espanhol | MEDLINE | ID: mdl-34495191

RESUMO

OBJECTIVE: to investigate associations between depressive symptoms during pregnancy, low birth weight, and prematurity among women with low-risk pregnancies assisted in public Primary Health Care services. METHOD: prospective cohort with 193 pregnant women, using the Edinburgh Postnatal Depression Scale, telephone interviews, and medical records available in the health services. Associations of interest were obtained using the Cox regression model. RESULTS: the participants were aged 24.9 years old (median) and had 11 years of schooling (median); 82.4% lived with their partners, and gestational age at the birth was 39 weeks (median). Twenty-five percent of the participants scored ≥13 on the Edinburgh scale. Depressive symptoms did not appear associated with low birth weight (RR=2.06; CI95%=0.56-7.61) or prematurity (RR=0.86; CI95%=0.24-3.09) in the adjusted analysis. However, premature labor increased the risk of low birth weight (RR=4.81; CI95%=1.01-23.0) and prematurity (RR=7.70; CI95%=2.50-23.7). Additionally, each week added to gestational age decreased the risk of low birth weight (RR=0.76; CI95%=0.61-0.95). CONCLUSION: the presence of depressive symptoms among women with low-risk pregnancies was not associated with low birth weight or prematurity.


Assuntos
Depressão , Gestantes , Adulto , Peso ao Nascer , Depressão/epidemiologia , Depressão/etiologia , Feminino , Serviços de Saúde , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Gravidez , Atenção Primária à Saúde , Estudos Prospectivos , Adulto Jovem
4.
Sultan Qaboos Univ Med J ; 21(3): 408-415, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34522406

RESUMO

Objectives: This study aimed to estimate the prevalence of social media usage and Internet addiction among Oman Medical Specialty Board (OMSB) residents and to determine associations between Internet addiction, sociodemographic characteristics and symptoms of depression. Methods: This cross-sectional study took place between January and March 2017. All 499 residents enrolled in OMSB training programmes during the 2016-2017 academic year were targeted. A self-administered questionnaire was distributed to collect information concerning sociodemographic characteristics. In addition, the Patient Health Questionnaire-9 and Internet Addiction Test were used to screen for depression and Internet addiction, respectively. Results: A total of 399 residents participated in the study (response rate: 80%). Overall, 115 residents (28.8%) had varying degrees of depression and 149 (37.3%) were addicted to the Internet; moreover, among those addicted, 54 (36.2%) had depression. While no significant associations were observed between Internet addiction and sociodemographic characteristics, the association between Internet addiction and depression was statistically significant (P = 0.012). Conclusion: Internet addiction was clearly detected among many OMSB residents, with a significant association observed between Internet addiction and depression. Although a causal link between these two variables cannot be established as depression is multifactorial in origin, the disadvantages and harmful effects of excessive Internet and social media usage need to be addressed. Further research on the consequences of Internet addiction and its effect on quality of life and academic achievement is recommended.


Assuntos
Comportamento Aditivo , Transtorno de Adição à Internet , Comportamento Aditivo/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Humanos , Qualidade de Vida
5.
Zhongguo Dang Dai Er Ke Za Zhi ; 23(9): 938-943, 2021.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-34535210

RESUMO

OBJECTIVES: To study the association of depression and suicidal ideation with parenting style in adolescents. METHODS: The cluster sampling method was used to select 6 195 junior and senior high school students in Xinxiang City of Henan Province, China, from 2014 to 2018. The survey tools included a general social information questionnaire, the Parental Bonding Instrument, and the Kutcher Adolescent Depression Scale (11 items). A multivariate logistic regression analysis was used to identify the association of depression and suicidal ideation with parenting style in adolescents. RESULTS: There were 6 194 valid questionnaires in total, including 2 586 boys (41.75%) and 3 608 girls (58.25%), with a mean age of (16.4±1.9) years (range: 11-20 years). Among these 6 194 students, 1 333 (21.52%) had depression, and 508 (8.20%) had suicidal ideation. Depression in adolescents was positively correlated with maternal control (OR=1.059, P<0.001) and paternal control (OR=1.061, P<0.001), but negatively correlated with maternal care (OR=0.937, P<0.001) and paternal care (OR=0.917, P<0.001). Suicide ideation in adolescents was positively correlated with maternal control (OR=1.110, P<0.001) and paternal control (OR=1.076, P<0.001), but negatively correlated with maternal care (OR=0.895, P<0.001) and paternal care (OR=0.914, P<0.001). CONCLUSIONS: Parental care may decrease the risk of depression and suicide ideation, while parental control may increase the risk of depression and suicide ideation in adolescents. Citation.


Assuntos
Poder Familiar , Ideação Suicida , Adolescente , Adulto , Criança , Depressão/epidemiologia , Depressão/etiologia , Feminino , Humanos , Masculino , Relações Pais-Filho , Fatores de Risco , Estudantes , Adulto Jovem
6.
JAMA Netw Open ; 4(8): e2121934, 2021 08 02.
Artigo em Inglês | MEDLINE | ID: mdl-34427678

RESUMO

Importance: The COVID-19 pandemic and resulting conditions may negatively affect adolescents. Objective: To examine aspects of self-reported mental and physical health among adolescents in Norway before and during the pandemic, including the role of pandemic-associated anxiety. Design, Setting, and Participants: This cohort study examined a diverse nationwide sample of grade 11 students from the longitudinal MyLife study in Norway. The original study recruitment of all 8th, 9th, and 10th graders from the same middle schools facilitated identification of 2 sociodemographically comparable cohorts assessed in October to December 2018 and 2019, before the COVID-19 pandemic, and October to December 2020, during the pandemic. School entry and enrollment in Norway is determined by the birth year, and students usually start high school (11th grade) during the fall of the year of their 16th birthday. Data were analyzed from March to June 2021. Exposures: The COVID-19 pandemic and associated conditions in Norway. Main Outcomes and Measures: In grades 10 and 11, adolescents reported their depression symptoms using the Patient Health Questionnaire-9 (cutoff scores for moderate/severe depression, ≥15), number of close friends, physical health, and organized sports participation. Cohort differences were examined with a set of nested regression models, incrementally controlling for sociodemographic covariates and grade 10 outcomes. Results: A sample of 2536 adolescents (1505 [59.4%] girls) was analyzed, including 1621 adolescents before the pandemic and 915 adolescents during the pandemic, of whom 158 adolescents (17.3%) reported high pandemic anxiety. The only significant difference in outcomes between the COVID-19 cohort and the pre-COVID-19 cohort were lower odds of organized sports participation (adjusted odds ratio [aOR], 0.69; 95% CI, 0.56-0.87). However, in subanalyses comparing adolescents with high anxiety during the COVID-19 pandemic with adolescents in the pre-COVID-19 cohort, adolescents with high pandemic anxiety were more likely to experience clinical-level depression symptoms (aOR, 2.17; 95% CI, 1.39-3.37) and poor physical health (aOR, 1.53; 95% CI, 1.01-2.31). Conclusions and Relevance: In this cohort study of Norwegian adolescents, adolescents who started high school during the pandemic year had lower odds of organized sports participation in late 2020, but were otherwise comparable in terms of self-reported mental and physical health with their pre-COVID-19 counterparts. However, adolescents in the COVID-19 cohort experiencing high pandemic-related anxiety had significantly greater odds of poorer mental and physical health than adolescents in the pre-COVID-19 cohort. Strategies aiming to mitigate the impact of COVID-19 may benefit from identifying youth disproportionally affected by the pandemic conditions.


Assuntos
Saúde do Adolescente , Ansiedade/epidemiologia , COVID-19 , Depressão/epidemiologia , Nível de Saúde , Saúde Mental , Pandemias , Adolescente , Ansiedade/etiologia , COVID-19/psicologia , Depressão/etiologia , Transtorno Depressivo/epidemiologia , Transtorno Depressivo/etiologia , Feminino , Humanos , Masculino , Noruega/epidemiologia , Razão de Chances , SARS-CoV-2 , Autorrelato , Esportes
7.
PLoS One ; 16(8): e0255774, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34379644

RESUMO

INTRODUCTION: Illnesses requiring hospitalization are known to negatively impact psychological well-being and health-related quality of life (HRQoL) after discharge. The impact of hospitalization during the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic on psychological well-being and health-related quality of life is expected to be higher due to the exceptional circumstances within and outside the hospital during the pandemic surge. The objective of this study was to quantify psychological distress up to three months after discharge in patients hospitalized during the first coronavirus disease 2019 (COVID-19) pandemic wave. We also aimed to determine HRQoL, to explore predictors for psychological distress and HRQoL, and to examine whether psychological distress was higher in COVID-19 confirmed patients, and in those treated in Intensive Care Units (ICUs). METHODS: In this single-center, observational cohort study, adult patients hospitalized with symptoms suggestive of COVID-19 between March 16 and April 28, 2020, were enrolled. Patients were stratified in analyses based on SARS-CoV-2 PCR results and the necessity for ICU treatment. The primary outcome was psychological distress, expressed as symptoms of post-traumatic stress disorder (PTSD), anxiety, and depression, up to three months post-discharge. Health-related quality of life (HRQoL) was the secondary outcome. Exploratory outcomes comprised predictors for psychological distress and HRQoL. RESULTS: 294 of 622 eligible patients participated in this study (median age 64 years, 36% female). 16% and 13% of these patients reported probable PTSD, 29% and 20% probable anxiety, and 32% and 24% probabledepression at one and three months after hospital discharge, respectively. ICU patients reported less frequently probable depression, but no differences were found in PTSD, anxiety, or overall HRQoL. COVID-19 patients had a worse physical quality of life one month after discharge, and ICU patients reported a better mental quality of life three months after discharge. PTSD severity was predicted by time after discharge and being Caucasian. Severity of anxiety was predicted by time after discharge and being Caucasian. Depression severity was predicted by time after discharge and educational level. CONCLUSION: COVID-19 suspected patients hospitalized during the pandemic frequently suffer from psychological distress and poor health-related quality of life after hospital discharge. Non-COVID-19 and non-ICU patients appear to be at least as affected as COVID-19 and ICU patients, underscoring that (post-)hospital pandemic care should not predominantly focus on COVID-19 infected patients.


Assuntos
COVID-19/diagnóstico , Angústia Psicológica , Qualidade de Vida , Adulto , Idoso , Idoso de 80 Anos ou mais , Ansiedade/etiologia , COVID-19/complicações , COVID-19/epidemiologia , COVID-19/virologia , Estudos de Coortes , Depressão/etiologia , Feminino , Hospitalização , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Pandemias , Alta do Paciente , SARS-CoV-2/genética , SARS-CoV-2/isolamento & purificação , Transtornos de Estresse Pós-Traumáticos/etiologia
8.
Eur J Obstet Gynecol Reprod Biol ; 264: 254-258, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34333367

RESUMO

OBJECTIVES: Endometriosis is a disease that significantly affects the quality of life of patients. Continuous pelvic pain seen in patients disrupts their well-being. The aim of this study is to examine the changes in depression and sleep disorders in patients with endometriosis before and after the operation. STUDY DESIGN: Forty-two women aged 18-49 with an indication for operation due to the diagnosis of stage 4 endometriosis and without a known psychiatric disorder were included in the study. Pittsburgh Sleep Quality Index and Beck Depression Inventory were used to compare sleep quality and mood of endometriosis patients before and after surgery. RESULTS: The mean age of the patients was 33.8 ± 7.6. The mean BMI of the patients was 24.6 ± 4.1. Endometrioma diameter was 248.42 ± 95.7 cm3 in patients with poor sleep quality, while it was 296.11 ± 271.53 cm3 in patients with good sleep quality, and a significant difference was observed (p < 0.05). Poor sleep quality and severe depression were significantly higher in patients with infertility complaints. It was observed that sleep quality was not significantly correlated with bilateral endometrioma, a nodule in the Douglas, sacrouterine tenderness and mean ASRM scores (p > 0.05). A significant decrease in depression complaints and a significant increase in sleep quality were observed in patients who underwent stage-4 endometriosis surgery (p < 0.05). CONCLUSION: We showed that there was a significant increase in sleep quality and a significant decrease in depression symptoms in patients who underwent stage-4 endometriosis surgery. Since endometriosis affects the social life of patients in many ways, it is necessary to increase the knowledge and experience about the treatment of endometriosis with larger studies to be done. We believe that surgical treatment can reduce social problems and increase the quality of life of endometriosis patients.


Assuntos
Endometriose , Transtornos do Sono-Vigília , Depressão/etiologia , Endometriose/complicações , Endometriose/cirurgia , Feminino , Humanos , Período Pós-Operatório , Qualidade de Vida , Transtornos do Sono-Vigília/etiologia
9.
BMJ Open ; 11(8): e050451, 2021 08 17.
Artigo em Inglês | MEDLINE | ID: mdl-34404715

RESUMO

INTRODUCTION: Post-stroke depression (PSD) is a severe complication of cerebrovascular stroke affecting about one-third of stroke survivors. Moreover, PSD is associated with functional recovery and quality of life (QOL) in stroke survivors. Screening for PSD is recommended. There are, however, differences in the literature on the impact of early screening on functional outcomes. In this systematic review, we synthesise the currently available literature regarding the associations between timing and setting of PSD screening and mortality, QOL and functional outcomes in stroke survivors. METHODS AND ANALYSIS: We will systematically search electronic databases including PubMed, Embase, APA PsycINFO, Web of Science, Scopus and CINAHL from inception to August 2021. Four reviewers will screen the title and abstract and full-text level records identified in the search in a blinded fashion to determine the study eligibility. Any selection disagreements between the reviewers will be resolved by the study investigator. Data extraction of eligible studies will be conducted by two reviewers using a predefined template. We will complete the quality assessment of included articles independently by two reviewers using the Newcastle Ottawa Scale. Eventual discrepancies will be resolved by the principal investigator. ETHICS AND DISSEMINATION: Due to the nature of the study design, ethical approval is not required. The systematic review and meta-analysis findings will be published and disseminated in a peer-reviewed journal. Our results will also be disseminated through posters and presentations at appropriate scientific conferences. PROSPERO REGISTRATION NUMBER: CRD42021235993.


Assuntos
Qualidade de Vida , Acidente Vascular Cerebral , Depressão/diagnóstico , Depressão/etiologia , Humanos , Metanálise como Assunto , Acidente Vascular Cerebral/complicações , Revisões Sistemáticas como Assunto
10.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 50(3): 298-304, 2021 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-34402249

RESUMO

To investigate the intestinal amino acids pathway in depression-like offspring rats induced by maternal separation. Sprague-Dawley (SD) female rats were randomly divided into a control group (=8) and a maternal separation group (=8). After normal delivery, the maternal rats were separated from offsprings for 14 consecutive days and 3 h per day in maternal separation group; while rats in the control group was received no interventions in postpartum. Depression-like behaviors of offspring rats were evaluated using the sucrose preference test, novelty suppressed feeding test, and forced swimming test. Amino acid analyzer was used to detect the changes of amino acid contents in the small intestine, and the expressions of alanine-serine-cysteine transporter 2 (ASCT2), solute carrier superfamily 6 member 19 (BAT1) and L-type amino acid transporter 1(LAT1) were detected by Western blot. The weight of the offspring rats in the maternal separation group was significantly lower than that of the control group at 21 and 28 d (=4.925 and 5.766, all <0.01). Compared with the control group, the percentage of sucrose preference of the offspring rats in the maternal separation group was significantly reduced (=2.709, <0.05), and the feeding latency was significantly prolonged (=-13.431, <0.01). The immobility time in FST of maternal separation group was significantly longer (=-3.616, <0.01).Increased concentration of aspartic acid (=-6.672, <0.01) and down-regulation of glutamine (=3.107, <0.01) and glycine (=9.781, <0.01) were observed in maternal separation group. Western blot analysis revealed that the protein expressions of ASCT2 (=6.734, <0.01) and BAT1 (=9.015, <0.01) in maternal separation group were reduced, while the expression of LAT1 was increased (=-8.942, <0.01). Maternal separation can induce the depression-like behavior in offspring rats; the amino acid contents and the amino acid transporter expression in the small intestine are reduced, which may be related to depression-like behavior induced by maternal separation.


Assuntos
Depressão , Privação Materna , Aminoácidos , Animais , Depressão/etiologia , Feminino , Hipocampo , Ratos , Ratos Sprague-Dawley
11.
Zh Nevrol Psikhiatr Im S S Korsakova ; 121(5. Vyp. 2): 84-90, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34405662

RESUMO

THE AIM OF THE STUDY: Was to investigate clinical and biochemical correlates of depression in the structure of schizophrenia to improve its diagnosis and differential diagnosis and to deepen understanding of mechanisms of schizophrenia development. Material and Methods. Forty-two inpatients at the stabilization stage of paranoid schizophrenia, aged 29.5±5.9 years, of whom 64.3% were women, were examined. The duration of the disease was 5.6±6.3 years. We used clinical and psychopathological methods, clinical scales (PANSS, SANS, BACS, Calgary Scale), catamnestic and clinic-laboratory methods (determination of brain-derived neurotrophic factor BDNF, proinflammatory cytokine interleukin-6, C-reactive protein). Results. At the stabilization stage, depression in patients with paranoid schizophrenia occurred in 19% of cases, more frequently in women. Female patients were more severely depressed, which was associated with an increased concentration of C-reactive protein, while negative symptoms predominated in male patients as compared to females. The presence of depression correlates with a lower severity of psychopathological, primarily positive symptoms and with a greater severity of neurocognitive deficit in schizophrenic patients. BDNF level directly correlates with the severity of positive and negative symptoms, and the level of interleukin 6 at the stage of remission formation does not differ from that in healthy individuals. C-reactive protein levels are associated with the characteristics of the course of schizophrenia.


Assuntos
Fator Neurotrófico Derivado do Encéfalo , Depressão , Adulto , Citocinas , Depressão/etiologia , Feminino , Humanos , Masculino , Escalas de Graduação Psiquiátrica , Esquizofrenia Paranoide/diagnóstico , Adulto Jovem
12.
Medicine (Baltimore) ; 100(32): e26869, 2021 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-34397901

RESUMO

ABSTRACT: Studies have shown that rapid rehabilitation surgery has a positive effect on recovery after major orthopedic surgery. However, very few studies have examined the impact of fast track surgery on physical and psychological rehabilitation in patients who have undergone total hip replacement.This study aimed to investigate the value of the rapid rehabilitation surgical model for patients undergoing total hip arthroplasty during the perioperative period.We conducted a prospective cohort study that included patients who underwent total hip arthroplasty at our hospital from January 2015 to December 2018. We divided the patients into 2 groups - the rapid rehabilitation group and the conventional rehabilitation group - and compared their length of hospital stay, time to off-bed activity, pain score, Self-Rating Anxiety Scale scores, Self-Rating Depression Scale scores, complication rate, and rate of satisfaction during hospitalization.A total of 348 patients were included in the study. Of these, 180 received rapid rehabilitation nursing and 168 patients received conventional nursing. Compared with the patients in the conventional rehabilitation group, those in the rapid rehabilitation group had shorter hospital stays (11.5 ±â€Š1.2 day vs 15.5 ±â€Š2.3 day, P = .021), resumed off-bed activities sooner (20.5 ±â€Š3.4 hours vs 61.8 ±â€Š4.7 hours, P = .001, had less postoperative pain (4.0 ±â€Š1.2 vs 6.5 ±â€Š1.1, P < .001), and lower anxiety and depression scores (anxiety score: 24.4 ±â€Š2.1 vs 47.9 ±â€Š2.9; depression score: 25.8 ±â€Š1.8 vs 43.7 ±â€Š1.7, P < .001).The application of rapid rehabilitation surgery in total hip arthroplasty can accelerate patients' postoperative recovery, relieve anxiety and depression, and increase the patient's satisfaction with the treatment.


Assuntos
Ansiedade , Artroplastia de Quadril , Depressão , Recuperação Pós-Cirúrgica Melhorada , Complicações Pós-Operatórias/prevenção & controle , Enfermagem em Reabilitação/métodos , Idoso , Ansiedade/etiologia , Ansiedade/prevenção & controle , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Artroplastia de Quadril/reabilitação , China/epidemiologia , Depressão/etiologia , Depressão/prevenção & controle , Feminino , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/cirurgia , Necrose da Cabeça do Fêmur/epidemiologia , Necrose da Cabeça do Fêmur/cirurgia , Humanos , Tempo de Internação , Masculino , Exercício Pré-Operatório/fisiologia , Exercício Pré-Operatório/psicologia , Estudos Prospectivos , Resultado do Tratamento
13.
Medicine (Baltimore) ; 100(33): e27018, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34414995

RESUMO

ABSTRACT: Breast cancer is the leading type of cancer among women worldwide, and a high number of breast cancer patients are suffering from psychological and cognitive disorders. This cross-sectional study used resting-state functional magnetic resonance imaging (rs-fMRI) and clinical neuropsychological tests to evaluate the possible underlying mechanisms.We enrolled 32 breast cancer patients without chemotherapy (BC), 32 breast cancer patients within 6 to 12 months after the completion of chemotherapy (BC_CTx) and 46 healthy controls. Participants underwent neuropsychological tests and rs-fMRI with mean fractional amplitude of low-frequency fluctuation and mean regional homogeneity analyses. Between groups whole-brain voxel-wise rs-fMRI comparisons were calculated using two-sample t test. rs-fMRI and neuropsychological tests correlation analyses were calculated using multiple regression. Age and years of education were used as covariates. A false discovery rate-corrected P-value of less than .05 was considered statistically significant.We found significantly alteration of mean fractional amplitude of low-frequency fluctuation and mean regional homogeneity in the frontoparietal lobe and occipital lobe in the BC group compared with the other 2 groups, indicating alteration of functional dorsal attention network (DAN). Furthermore, we found the DAN alteration was correlated with neuropsychological impairment.The majority of potential underlying mechanisms of DAN alteration in BC patients may due to insufficient frontoparietal lobe neural activity to drive DAN and may be related to the effects of neuropsychological distress. Further longitudinal studies with comprehensive images and neuropsychological tests correlations are recommended.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/etiologia , Neoplasias da Mama/tratamento farmacológico , Tratamento Farmacológico/estatística & dados numéricos , Sobreviventes/estatística & dados numéricos , Adulto , Ansiedade/etiologia , Ansiedade/psicologia , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Neoplasias da Mama/complicações , Estudos Transversais , Depressão/etiologia , Depressão/psicologia , Tratamento Farmacológico/métodos , Feminino , Humanos , Pessoa de Meia-Idade , Taiwan
14.
Malawi Med J ; 33(1): 54-58, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-34422234

RESUMO

Background: Several studies have been published on the topic of COVID-19 and pregnancy over recent months. However, few studies have evaluated the impact of this pandemic on maternal mental health, particularly in low-resource settings. Aim: To determine the prevalence and predictors of COVID-19-related depression, anxiety and stress symptoms among pregnant women. Methods: This was a cross-sectional study that involved 456 pregnant women attending prenatal care at Abakaliki, Nigeria, during the COVID-19 lockdown. These patients were screened for psychological morbidities using the Depression Anxiety and Stress Scale-21 (DASS-21). Results: Severe and extremely severe depression were reported in 7.2% (n=33) and 6.4% (n=29) of participants, respectively. Analysis also revealed that 3.3% (n=15) and 7.7% (n=35) of women had severe and extremely severe anxiety, respectively. In total, 23% (n=105) of the participating women had severe stress while 16.7% (n=76) reported extremely severe stress. Multiparity (2-4) and occupation, such as trading and farming, were predictors of depression whereas grand-multiparity, urban residence, and trading, were identified as predictors of anxiety and stress. Conclusion: Symptoms of depression, anxiety and stress were relatively common among pregnant women during the COVID-19 lockdown in Abakaliki, Nigeria. There is a clear need to integrate screening for depression, anxiety and stress, in existing antenatal care programs so as to identify and prevent long-term adverse psychological outcomes related to the COVID-19 pandemic.


Assuntos
Transtornos de Ansiedade/epidemiologia , COVID-19/epidemiologia , Depressão/epidemiologia , Saúde Materna , Complicações na Gravidez/epidemiologia , Quarentena , Estresse Psicológico/epidemiologia , Adulto , Transtornos de Ansiedade/etiologia , COVID-19/complicações , Estudos Transversais , Depressão/etiologia , Feminino , Humanos , Nigéria/epidemiologia , Pandemias , Gravidez , Prevalência , Escalas de Graduação Psiquiátrica , Estudos Retrospectivos , SARS-CoV-2 , Estresse Psicológico/etiologia
15.
Chem Biol Interact ; 347: 109603, 2021 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-34352274

RESUMO

AIMS: Major depressive disorder (MDD) affects approximately 322 million people worldwide and is a common comorbidity in patients with diabetes mellitus (DM). A possible pathophysiological mechanism correlating both diseases is the increased oxidative stress in brain regions due to hyperglycemia. Myrsine coriacea (Primulaceae) is popularly known as "capororoca" and studies have been shown that this plant exhibits several pharmacological properties attributed to myrsinoic acid A (MAA) and B (MAB). Indeed, previous results have been shown its effects on the central nervous system, leading us to explore possible psychotropic effects. MAIN METHODS: The effects of treatment with hydroalcoholic extract of the barks from Myrsine coriacea (HEBMC, 150 mg/kg, o.g.), MAA (5 mg/kg, o.g.), and MAB (3 mg/kg, o.g.) were evaluated in streptozotocin (75 mg/kg, i.p.)-induced diabetic female rats. After 28 days of treatments, rats were submitted to the forced swim test (FST) and open field test (OFT). Also, superoxide dismutase (SOD) and catalase (CAT) activities, reduced glutathione (GSH) and lipid hydroperoxides (LOOH) levels were evaluated in the hippocampus (HIP) and prefrontal cortex (PFC) of these rats. KEY FINDINGS: The treatment with MAA or MAB increased the latency of first immobility in diabetic rats, and the HEBMC administration decreased the immobility time, and increase the climbing in FST. However, only MAB treatment reduces the immobility time, increases the climbing, and swimming in FST, and increases the crossing of diabetic animals in the OFT. Besides, this behavioral improvement promoted by MAB administration was accompanied by reducing in oxidative stress in the HIP and PFC, but not reducing hyperglycemia in diabetic rats. SIGNIFICANCE: The results suggest that MAB's antioxidant effect in the HIP of diabetic animals may be essential to its antidepressant-like effect.


Assuntos
Alcenos/uso terapêutico , Antidepressivos/uso terapêutico , Benzofuranos/uso terapêutico , Depressão/prevenção & controle , Hipocampo/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Córtex Pré-Frontal/efeitos dos fármacos , Animais , Catalase/metabolismo , Depressão/etiologia , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/complicações , Diabetes Mellitus Experimental/metabolismo , Feminino , Myrsine/química , Teste de Campo Aberto/efeitos dos fármacos , Casca de Planta/química , Extratos Vegetais/uso terapêutico , Caules de Planta/química , Ratos Wistar , Estreptozocina
16.
PLoS One ; 16(8): e0255183, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34358235

RESUMO

BACKGROUND: The 2019 coronavirus disease (COVID-19) pandemic resulted in the closure of businesses and schools, the remote provision of services and the disruption of the services of professional childminders. These disruptions resulted in a significant increase in parental responsibility for childcare. Such a substantial increase in time requirements for childcare domestically has potential mental health consequences. We therefore ascertained the relationship between childcare and depression in South Africa during the pandemic. METHODS: Data came from the National Income Dynamics Study-Coronavirus Rapid Mobile Survey, a longitudinal telephonic survey conducted during the COVID-19 pandemic in South Africa. The outcome was a depression index obtained from the two-item Patient Health Questionnaire while the main covariate was the average number of hours spent in taking care of children per weekday. We employed the ordered logit model. FINDINGS: We found a positive relationship between spending more hours on childcare and worse depressive health for caregivers in both periods analyzed. Childcare responsibilities preventing/mitigating the ability of caregivers to work as well as preventing caregivers from searching for jobs moderated the depression-childcare relationship. CONCLUSION: These findings highlight the need to carefully consider policy responses aimed at containing the pandemic. We advocate a multi-stakeholder approach to mitigating the mental health impact of COVID-19 by encouraging more collaboration between government, school authorities, employers and parents/guardians.


Assuntos
COVID-19 , Cuidado da Criança , Depressão/etiologia , Adolescente , Adulto , COVID-19/epidemiologia , Cuidadores , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pandemias , África do Sul/epidemiologia
17.
Artigo em Inglês | MEDLINE | ID: mdl-34360348

RESUMO

Stroke is a high-risk factor for depression. Neurological rehabilitation is greatly difficult and often does not include treatment of depression. The post-stroke depression plays an important role in the progress of treatment, health, and the life of the patient. The appropriate treatment of depression could improve the quality of life of the patient and their family. The study aimed to evaluate the impact of physical activity and socio-economic status of the patient on the effectiveness of recovery from depression and the severity of the symptoms of depression. The study was conducted with 40 patients after stroke aged 42-82 years, and included 10 women and 30 men who were hospitalized for two weeks. The severity of depression/anxiety (D/A) symptoms were evaluated two times; at admission and after two weeks of physical therapy. The hospital anxiety and depression scale (HADS) questionnaire was used for this purpose. Socio-economic status was evaluated by several simple questions. It was revealed that physical therapy has a positive influence on mental state. The severity of D/A symptoms after stroke is related to the financial status of the patients (χ2 = 11.198, p = 0.024). The state of health (χ2 = 20.57, p = 0.022) and physical fitness (χ2 = 12.95, p = 0.044) changed the severity of symptoms of anxiety and depressive disorders. The kinesiotherapy in the group of patients with post-stroke depression had positive effects; however, economic and health conditions may influence the prognosis of the disease.


Assuntos
Depressão , Acidente Vascular Cerebral , Ansiedade/epidemiologia , Ansiedade/etiologia , Depressão/epidemiologia , Depressão/etiologia , Status Econômico , Exercício Físico , Feminino , Humanos , Masculino , Qualidade de Vida , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/epidemiologia
18.
PLoS One ; 16(8): e0256041, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34407127

RESUMO

Despite the severe psychological impact of the COVID-19 pandemic, some individuals do not develop high levels of psychological distress and can be termed resilient. Using the ecological resilience model, we examined factors promoting or hindering resilience in the COVID-19 pandemic. Of the 1034 participants (49.9±16.2 years; females 51.2%) from Italian general population, 70% displayed resilient outcomes and 30% reported moderate-severe anxiety and/or depression. A binary regression model revealed that factors promoting resilience were mostly psychological (e.g., trait resilience, conscientiousness) together with social distancing. Conversely, factors hindering resilience included COVID-19-anxiety, COVID-19-related PTSD symptoms, intolerance of uncertainty, loneliness, living with children, higher education, and living in regions where the virus was starting to spread. In conclusion, the ecological resilience model in the COVID-19 pandemic explained 64% of the variance and identified factors promoting or hindering resilient outcomes. Critically, these findings can inform psychological interventions supporting individuals by strengthening factors associated with resilience.


Assuntos
Ansiedade/epidemiologia , COVID-19/psicologia , Depressão/epidemiologia , Resiliência Psicológica , Adulto , Idoso , Ansiedade/etiologia , Estudos Transversais , Depressão/etiologia , Feminino , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Modelos Psicológicos , Distanciamento Físico , Fatores de Risco
19.
Epilepsy Behav ; 122: 108201, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34273741

RESUMO

OBJECTIVES: To confirm whether the prevalence of depression in patients with epilepsy (PWE) is different between the sexes, whether risk factors for depression vary between the sexes, and whether the association between cognitive function and depression in PWE is influenced by patient sex. METHODS: A cohort of consecutive PWE from the First Hospital of Jilin University (Changchun, China) was recruited. Depressive symptoms were evaluated using the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy scale, and multivariate logistic regression analyses were used to identify independent risk factors for depression in both male and female PWE. RESULTS: Female PWE experienced more serious depressive symptoms (p = 0.001) than male PWE. Risk factors affecting comorbid depression varied according to sex. Among male PWE, per capita monthly family income (odds ratio [OR] 0.515 [95% confidence interval (CI) 0.311-0.851]; P = 0.01), seizure frequency over the past year (OR 1.586 [95% CI 1.019-2.468], P = 0.041), polytherapy (OR 0.446 [95% CI 0.214-0.931]; P = 0.032), and Montreal Cognitive Assessment (MoCA) scale score (OR 0.926 [95% CI 0.873-0.982]; P = 0.011) were independent risk factors for depression. Among female PWE, educational level (OR 0.604 [95% CI 0.364-1]; P = 0.05) and MoCA scale score (OR 0.921 [95% CI 0.859-0.987]; P = 0.02) were independent risk factors for depression. CONCLUSION: Depression was a common psychiatric comorbidity among PWE, and the prevalence of and risk factors for depression differed between males and females.


Assuntos
Depressão , Epilepsia , Adulto , China/epidemiologia , Depressão/epidemiologia , Depressão/etiologia , Epilepsia/complicações , Epilepsia/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Fatores de Risco
20.
Ther Umsch ; 78(6): 299-304, 2021 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-34291664

RESUMO

Post stroke depression Abstract. Post stroke depression is a common psychiatric disorder after a cerebrovascular insult. It effects the outcome of the rehabilitation after the stroke and leads to an increased mortality. The symptomatic description of the depressive symptoms is done according to the ICD-10 criteria. The following article aims to provide an overview of the etiologic theories, diagnostic approaches, and therapeutic strategies regarding PSD.


Assuntos
Transtorno Depressivo , Acidente Vascular Cerebral , Depressão/diagnóstico , Depressão/etiologia , Depressão/terapia , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/etiologia , Transtorno Depressivo/terapia , Humanos , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/terapia
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