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1.
An Bras Dermatol ; 95(2): 194-199, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32156503

RESUMO

BACKGROUND: Kathon CG, a combination of methylchloroisothiazolinone and methylisothiazolinone, is widely used as preservative in cosmetics, as well in household cleaning products, industrial products such as paints and glues. It has emerged as an important sensitizing agent in allergic contact dermatitis. OBJECTIVES: This study evaluated the reactivity to this substance in patients subjected to patch tests at the Dermatology Institute in Bauru, São Paulo from 2015 to 2017 and its correlation with other preservatives, the professional activity and location of the lesions. METHODS: The patients were submitted to standard series of epicutaneous tests, standardized by the Brazilian Group Studies on Contact Dermatitis. RESULTS: Out the 267 patients tested, 192 presented positivity to at least one substance and 29 of the patients (15.10%) presented reaction to Kathon CG, with predominance of the female gender (n=27); main professional activity associated with Kathon CG sensibilization was cleaning (17.24%), followed by aesthetic areas (13.79%) and health care (10.34%). The most prevalent sensitizations among the substances tested were nickel sulphate (56.3%), followed by cobalt chloride (23.4%), neomycin (18.2%), potassium dichromate (17.7%), thimerosal (14.5%), formaldehyde (13.2%), paraphenylenediamine (9.3%), and fragrance mix (8.3%). STUDY LIMITATIONS: We do not have data from patients that were submitted to patch test a decade ago in order to confront to current data and establish whether or no sensitization to Kathon CG has increased. CONCLUSION: High positivity to Kathon CG corroborates the recent findings in the literature, suggesting more attention to concentration of this substance, used in cosmetics and products for domestic use.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Testes do Emplastro/métodos , Tiazóis/análise , Adulto , Brasil , Cosméticos/efeitos adversos , Cosméticos/química , Dermatite Alérgica de Contato/etiologia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro/estatística & dados numéricos , Conservantes Farmacêuticos/efeitos adversos , Conservantes Farmacêuticos/química , Estudos Retrospectivos , Estatísticas não Paramétricas , Tiazóis/efeitos adversos
3.
Hautarzt ; 71(3): 205-210, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31965206

RESUMO

The design and development of insulin pumps and various glucose sensor systems has an enormous impact on life quality of diabetic patients. Surveillance and therapy of diabetes has improved due to the new diabetic devices, which are affixed to the patients' skin for several days. Since their introduction, irritant and allergic contact dermatitis have been frequently reported. Patients often acquire contact sensitization to isobornyl acrylate, N,N-dimethylacrylamide or formerly to 2­ethyl-cyanoacrylate. These contact allergens were found in the patch, in the glue to affix the box on the patch or in the casing of the system itself. Development of contact allergy to substances of these systems may result in the need to abandon modern diabetic devices.


Assuntos
Adesivos/efeitos adversos , Alérgenos/efeitos adversos , Automonitorização da Glicemia/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Inflamação/etiologia , Sistemas de Infusão de Insulina/efeitos adversos , Testes do Emplastro/métodos , Acetatos , Automonitorização da Glicemia/instrumentação , Compostos Bicíclicos com Pontes , Dermatite Alérgica de Contato/prevenção & controle , Diabetes Mellitus , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/tratamento farmacológico , Reação a Corpo Estranho/etiologia , Glucose , Humanos , Insulinas/administração & dosagem , Insulinas/uso terapêutico
4.
Hautarzt ; 71(3): 197-204, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31965209

RESUMO

BACKGROUND: Fragrances are regarded as the most common contact allergens after nickel. In this context, the frequency of positive patch test reactions to fragrance mix is often presented as proof. According to EU regulation No. 1223/2009, 26 fragrances that are regarded as significant allergens have to be declared on cosmetic products. OBJECTIVES: The frequency of patch test reactions to fragrances and differentiation between frequently and rarely sensitizing fragrances were evaluated. MATERIALS AND METHODS: Data from the Information Network of Departments of Dermatology (IVDK), mostly of the years 2016-2018, were retrospectively analyzed. RESULTS: Frequency of positive reactions to fragrance mix I in the departments of dermatology joining the IVDK reached a historical low of 5.4% in 2018. Since 2013, positive reactions to fragrance mix II have been declining, yielding 3.2% in 2018. Of fragrance mix I, the allergen with the most positive test reactions is no longer oakmoss absolute, but isoeugenol. In fragrance mix II, hydroxyisohexyl 3­cyclohexene carboxaldehyde (HICC) is still leading. Only 11 of the 26 fragrances subject to mandatory declaration elicited allergic test reactions in more than 1% of the patients tested. DISCUSSION: The decline of positive test reactions to the fragrance mixes is mainly due to the reduced use of oakmoss containing atranol and chloroatranol, and HICC. Use of these substances in cosmetic products was prohibited within the EU starting in August 2019. Therefore, a further decline of the sensitization frequencies can be expected. A differentiated consideration of the individual fragrances under allergological aspects is urgently required.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Odorantes , Perfumes/efeitos adversos , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Humanos , Testes do Emplastro , Estudos Retrospectivos
5.
Biosci Biotechnol Biochem ; 84(1): 208-215, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31532348

RESUMO

Dihomo-γ-linolenic acid (DGLA, C20: 3n-6) is known to have an anti-inflammatory activity, but its range of effects was not well studied because of its limited natural sources. We addressed these issues by constructing an yeast Saccharomyces cerevisiae strain having a complete metabolic pathway for DGLA synthesis by introducing two desaturase and one elongase genes to convert endogenous oleic acid to DGLA. Taking advantage of well-known safety of S. cerevisiae, we previously investigated the efficacy of heat-killed whole DGLA-producing yeast cells on irritant contact dermatitis, and showed that oral intake of this yeast significantly suppressed inflammatory reactions, whereas no such suppression was observed by the intake of 25 times the amount of purified DGLA. Since this method is considered to be a simple and efficient way to suppress inflammation, we examined its effectiveness against allergic contact dermatitis (ACD) in this study and showed that this method was also effective against ACD.


Assuntos
Ácido 8,11,14-Eicosatrienoico/farmacologia , Terapia Baseada em Transplante de Células e Tecidos/métodos , Dermatite Alérgica de Contato/terapia , Saccharomyces cerevisiae/citologia , Saccharomyces cerevisiae/metabolismo , Ácido 8,11,14-Eicosatrienoico/administração & dosagem , Ácido 8,11,14-Eicosatrienoico/metabolismo , Acetona/química , Administração Oral , Animais , Quimiocina CCL2/análise , Quimiocinas/análise , Dermatite Alérgica de Contato/etiologia , Dinitrofluorbenzeno/efeitos adversos , Dinitrofluorbenzeno/imunologia , Orelha Externa/patologia , Feminino , Imunização , Inflamação/terapia , Interferon gama/análise , Camundongos , Ácido Oleico/metabolismo , Azeite de Oliva/química
7.
Hautarzt ; 70(12): 948-952, 2019 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-31754739

RESUMO

Resorcinol is a frequently used hair dye, whose quantitative risk assessment (QRA) for hair color products is presented in this review as an example to assess its skin sensitization risk after topical application. Its purpose is to determine the maximum concentration that can be used without expecting skin sensitization to occur. The focus is to prevent the de novo development of a contact allergy. Epidemiological data which are provided via dermatological surveillance, e.g., by the IVDK (Information Network of Departments of Dermatology) in Germany, are an important source of information that help to assess the quality and the effectivity of the QRA.


Assuntos
Alérgenos , Dermatite Alérgica de Contato , Resorcinóis , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/prevenção & controle , Alemanha , Humanos , Testes do Emplastro , Resorcinóis/efeitos adversos , Medição de Risco , Pele
8.
Ecotoxicol Environ Saf ; 186: 109772, 2019 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-31614297

RESUMO

Trichloroethylene (TCE) is a common organic solvent which can cause TCE hypersensitivity syndrome (THS) in exposure workers. THS is an adverse skin disorder with severe inflammatory kidney damage. Complement C3a receptor (C3aR) acts as a specific receptor for the key complement cleavage product C3a and involves multiple inflammatory responses, but the role of C3aR in TCE induced kidney inflammatory injury remains unknown. In this study, BALB/c mouse model of skin sensitization induced by TCE was set up in the presence or absence of C3aR antagonist (C3aRA). Kidney pathology and renal function, expression of inflammatory mediators and C3aR, changes in Th17 cell numbers, and activation of signal transducer and activator of transcription 3 (STAT3) in the kidney were examined. TCE sensitization produced histopathological and functional damage to the kidney, accompanied by increased levels of interleukin (IL-) 1ß, IL-6, and IL-23. Local accumulation of Th17 cells and enhanced phosphorylation of STAT3 were also seen in the impaired kidney in TCE sensitization-positive mice. C3aR was mainly located in the impaired glomerulus and upregulated in TCE sensitization-positive mice. C3aRA pretreatment alleviated the structural and functional kidney damage and the inflammatory cytokine and Th17 responses by TCE sensitization, and specifically reduced the phosphorylation of STAT3. Together, our results demonstrate that C3aR signaling promotes the inflammatory responses and regulates the accumulation of Th17 phenotype via phosphorylation of STAT3 in TCE sensitization induced inflammatory kidney damage. C3aR may serve as a potential therapeutic target in TCE sensitization mediated kidney injury.


Assuntos
Dermatite Alérgica de Contato/etiologia , Rim/efeitos dos fármacos , Receptores de Complemento/metabolismo , Células Th17/imunologia , Tricloroetileno/toxicidade , Animais , Citocinas/sangue , Dermatite Alérgica de Contato/imunologia , Dermatite Alérgica de Contato/patologia , Rim/imunologia , Rim/patologia , Testes de Função Renal , Camundongos , Camundongos Endogâmicos BALB C , Fenótipo , Fator de Transcrição STAT3/metabolismo , Transdução de Sinais , Células Th17/patologia
9.
Cutis ; 104(2): 94-96, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31603959

RESUMO

Methylisothiazolinone (MI) is a preservative commonly used in water-based personal care products. Increases in the allowable concentration of MI alone in these products has led to an epidemic of allergic contact dermatitis (ACD). Although personal care products are the most common source of MI contact allergy, other novel exposures include household products, industrial chemicals, paint, slime, and adhesive agents. Other isothiazolinones such as benzisothiazoline (BIT) and octylisothiazolinone (OIT) are uncommon in personal care products but have been found in leather products, glue, industrial chemicals, paints, and cleaning products. There may be cross-reactivity between OIT and MI, and a minority of patients who are allergic to MI are cosensitized to BIT. In this article, we review MI and related isothiazolinone chemicals.


Assuntos
Dermatite Alérgica de Contato/etiologia , Conservantes Farmacêuticos/efeitos adversos , Tiazóis/efeitos adversos , Cosméticos/efeitos adversos , Cosméticos/química , Reações Cruzadas , Humanos , Conservantes Farmacêuticos/administração & dosagem , Tiazóis/administração & dosagem
10.
J Drugs Dermatol ; 18(10): 1002-1004, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31584778

RESUMO

Lanolin alcohol is a high cholesterol containing naturally derived material used as a skin protectant in wound healing petrolatum-based ointments. It is a highly purified fraction of lanolin wool wax that has been identified as a possible cause of allergic contact dermatitis. This 3-center study enrolled 499 subjects who underwent a variety of in-office surgical procedures followed by application of a wound healing ointment containing lanolin alcohol without antibiotics. No allergic contact dermatitis was identified in the 499 subjects who completed the study. The lack of allergic contact dermatitis observed may be due to the proprietary highly purified lanolin alcohol utilized in the study formulation. This is not the lanolin alcohol preparation found on the standard dermatology patch test tray. Not all lanolin alcohols are equal. This is an important consideration when examining the reported incidence of allergic contact dermatitis to lanolin alcohol and the absence of allergic contact dermatitis demonstrated in this research. J Drugs Dermatol. 2019;18(10):1002-1004.


Assuntos
Dermatite Alérgica de Contato/epidemiologia , Lanolina/efeitos adversos , Vaselina/efeitos adversos , Ferida Cirúrgica/tratamento farmacológico , Adolescente , Adulto , Idoso , Estudos de Coortes , Dermatite Alérgica de Contato/etiologia , Feminino , Humanos , Lanolina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Bases para Pomadas , Pomadas , Vaselina/administração & dosagem , Prevalência , Resultado do Tratamento , Cicatrização/efeitos dos fármacos , Adulto Jovem
11.
Toxicol Lett ; 317: 68-81, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31580885

RESUMO

Skin sensitization, frequently leading to allergic contact dermatitis (ACD), is authenticated to be a significant endpoint in the field of drug discovery and cosmetics. The initiation of ACD, also known as the skin sensitization mechanism, has been documented as an adverse outcome pathway (AOP), which can be studied experimentally and computationally. In this study, we collected 154 haptens and applied systems toxicology methods to develop a reaction-substructure-compound- target-pathway network system. For the collected haptens, their key substructures were identified and associated with their protein binding reactions. The targets of haptens, including the known targets collected from four databases and the potential targets predicted via our balanced substructure-drug-target network-based inference (bSDTNBI) method, were matched to skin proteins to obtain skin targets. The dermatitis-related pathways were enriched and were subject to literature verification. The network system we developed can be applied to predict the reactions, targets and pathways of new haptens, which contributed to evaluating chemical safety and optimizing chemical structures. The study of skin sensitization mechanism is helpful for understanding the skin immunity and resisting ACD.


Assuntos
Dermatite Alérgica de Contato/etiologia , Haptenos/toxicidade , Pele/efeitos dos fármacos , Biologia de Sistemas , Toxicologia/métodos , Animais , Dermatite Alérgica de Contato/imunologia , Dermatite Alérgica de Contato/metabolismo , Haptenos/química , Humanos , Estrutura Molecular , Ligação Proteica , Mapas de Interação de Proteínas , Medição de Risco , Transdução de Sinais/efeitos dos fármacos , Pele/imunologia , Pele/metabolismo , Relação Estrutura-Atividade
12.
Ned Tijdschr Geneeskd ; 1632019 09 16.
Artigo em Holandês | MEDLINE | ID: mdl-31556491

RESUMO

The most common side effects of transdermal patches are mechanical reactions caused by applying or removing the transdermal patch, or by excessive perspiration under the patch. Allergic contact dermatitis (type IV allergic reaction) is the most commonly occurring hypersensitivity reaction and can be caused by the active substance or by excipients. Type I allergic reactions such as urticaria, bronchospasm and angioedema are rare and usually caused by the active substance in the patch. Allergy testing to determine the allergen is indicated following a type I allergic reaction, or after a type IV allergic reaction that requires an alternative for the patch. It is important to document hypersensitivity reactions in the electronic patient records in order to prevent a hypersensitivity reaction in the future.


Assuntos
Dermatite Alérgica de Contato/etiologia , Excipientes/efeitos adversos , Adesivo Transdérmico/efeitos adversos , Angioedema/etiologia , Dermatite Alérgica de Contato/diagnóstico , Feminino , Humanos , Masculino , Testes Cutâneos , Urticária/etiologia
13.
Dermatitis ; 30(5): 306-313, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31524759

RESUMO

BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). RESULTS: A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. CONCLUSIONS: Occupational nickel allergy is distinct from nonoccupational nickel allergy.


Assuntos
Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Níquel/toxicidade , Exposição Ocupacional/efeitos adversos , Adolescente , Adulto , Fatores Etários , Braço , Estudos Transversais , Dermatite Alérgica de Contato/diagnóstico , Dermatite Ocupacional/diagnóstico , Feminino , Dermatoses da Mão/induzido quimicamente , Dermatoses da Mão/epidemiologia , Humanos , Indústrias/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , América do Norte/epidemiologia , Ocupações/estatística & dados numéricos , Testes do Emplastro , Estudos Retrospectivos , Fatores Sexuais , Adulto Jovem
14.
Dermatitis ; 30(5): 314-322, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31517667

RESUMO

BACKGROUND: Cyanoacrylates are strong adhesives used for a variety of medical, industrial, and cosmetic applications and have been implicated as a cause of allergic contact dermatitis. OBJECTIVE: The aim of the study was to review our experience in patch testing with cyanoacrylates. METHODS: We reviewed patch test results of 38 patients with a clinical history of contact dermatitis due to a cyanoacrylate-containing adhesive (mostly Dermabond). Testing used cyanoacrylates of >99% purity diluted to 10% to 30% in petrolatum (pet.), undiluted octyl cyanoacrylate, and/or Dermabond Mini or Advanced "as is." Patch tests were also performed with methacrylates, formaldehyde (a cyanoacrylate impurity), benzalkonium chloride, and cyanoacrylate polymerization inhibitors. Three patients were also tested with Dermabond Mini on abraded skin. RESULTS: Commercial cyanoacrylate patch testing material (ethyl cyanoacrylate 10% pet.) detected 29% of Dermabond-allergic patients, whereas patch testing with octyl cyanoacrylate 10% pet. increased detection to 50%. Testing with higher concentrations and/or on abraded skin further increased yield. Thirteen (37%) of our 35 cyanoacrylate-allergic patients were also allergic to methacrylates or acrylates. CONCLUSIONS: Octyl cyanoacrylate is the usual allergenic ingredient in Dermabond. Patch testing with high concentrations is often required. Testing Dermabond on abraded skin further improves diagnostic sensitivity by more closely simulating clinical use.


Assuntos
Cianoacrilatos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Testes do Emplastro , Adesivos Teciduais/efeitos adversos , Humanos , Metacrilatos/efeitos adversos , Testes do Emplastro/métodos
15.
Chin Med J (Engl) ; 132(16): 1959-1964, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31373908

RESUMO

BACKGROUND: Nickel-induced allergic contact dermatitis (Ni-ACD) is a global health problem. More detailed knowledge on the skin uptake of haptens is required. This study aimed to investigate the penetration process and distribution of nickel in skin tissues with late phase and early phase of Ni-ACD to understand the mechanisms of metal allergy. METHODS: Forty Hartley guinea pigs were divided into four groups according to the NiSO4 sensitizing concentration and the NiSO4 challenged concentration: the 5% NiSO4-group, 5% to 10% (sensitization-challenge; late phase group); 10% NiSO4-group, 10% to 10% (sensitization-challenge; early-phase group); and the positive and negative controls. Pathological biopsies were performed on each group. The depth profile of nickel element concentration in the skin of guinea pigs was detected by synchrotron radiation micro X-ray fluorescence spectroscopy (SR-µ-XRF) and micro X-ray absorption near-edge spectroscopy (µ-XANES). RESULTS: In each section, the nickel element concentration in both the 5% NiSO4-group and 10% NiSO4-group was significantly higher than that in the negative control group. In the upper 300-µm section of skin for the early phase group, the nickel element concentration was significantly higher than that in the lower section of skin. In deeper sections (>200 µm) of skin, the concentration of nickel in the early phase group was approximately equal to that in the late phase group. The curve of the late phase group was flat, which means that the nickel element concentration was distributed uniformly by SR-µ-XRF. According to the XANES data for the 10% NiSO4 metal salt solution, structural changes occurred in the skin model sample, indicating that nickel was not present in the Ni aqueous ionic state but in the nickel-binding protein. CONCLUSIONS: This study showed that the distribution of the nickel element concentration in ACD skin tissue was different between the early phase and late phase groups. The nickel element was not present in the Ni aqueous ionic state but bound with certain proteins to form a complex in the stratum corneum in ACD model tissue.


Assuntos
Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/metabolismo , Níquel/metabolismo , Níquel/toxicidade , Espectrometria por Raios X/métodos , Animais , Dermatite Alérgica de Contato/patologia , Feminino , Cobaias , Masculino , Distribuição Aleatória , Pele/metabolismo , Pele/patologia
16.
Regul Toxicol Pharmacol ; 108: 104445, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31430506

RESUMO

In a regulatory context, skin sensitization hazard and risk evaluations of manufactured products and their ingredients (e.g. cosmetics) are mandatory in several regions. Great efforts have been made within the field of 21st Century Toxicology to provide non-animal testing approaches to assess the skin allergy potential of materials (e.g. chemicals, mixtures, nanomaterials, particles). Mechanistic understanding of skin sensitization process through the adverse outcome pathway (AOP) has promoted the development of in vitro methods, demonstrating accuracies superior to the traditional animal testing. These in vitro testing approaches are based on one of the four AOP key events (KE) of skin sensitization: formation of immunogenic hapten-protein complexes (KE-1 or the molecular initiating event, MIE), inflammatory keratinocyte responses (KE-2), dendritic cell activation (KE-3), and T-lymphocyte activation and proliferation (KE-4). This update provides an overview of the historically used in vivo methods as well as the current in chemico and in cell methods with and without OECD guideline designations to analyze the progress towards human-relevant in vitro test methods for safety assessment of the skin allergenicity potential of materials. Here our focus is to review 96 in vitro testing approaches directed to the KEs of the skin sensitization AOP.


Assuntos
Alternativas aos Testes com Animais , Haptenos/toxicidade , Animais , Dermatite Alérgica de Contato/etiologia , Humanos , Técnicas In Vitro , Medição de Risco
18.
BMC Ophthalmol ; 19(1): 158, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31340775

RESUMO

BACKGROUND: To report the first case of allergic contact dermatitis (ACD) associated with alcaftadine 0.25% ophthalmic solution. CASE PRESENTATION: The patient was a 51-year-old woman with no previous history of side effects to ophthalmic antihistamine agents. She had been prescribed alcaftadine 0.25% for allergic conjunctivitis. On first application of the medication, she did not experience any cutaneous reaction. One day later, after the second alcaftadine 0.25% application, both eyelids became swollen, and erythematous changes were evident. On slit-lamp examination, conjunctival injection was noted in the absence of conjunctival swelling or any other findings. Fundus examination was unremarkable. To evaluate the cause of ACD, a patch test was performed and 48 h later was noted to be positive for alcaftadine 0.25%. Based on the positive patch test, the patient was diagnosed with ACD caused by alcaftadine 0.25%. After 9 days of treatment, the swelling and erythema completely resolved. CONCLUSIONS: Although there have been no previous reports of alcaftadine 0.25%-associated ACD, it should be suspected in patients with swelling and erythematous change of both eyes after using alcaftadine 0.25%.


Assuntos
Benzazepinas/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Imidazóis/efeitos adversos , Administração Oral , Benzazepinas/administração & dosagem , Conjuntivite Alérgica/tratamento farmacológico , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/tratamento farmacológico , Feminino , Glucocorticoides/administração & dosagem , Antagonistas dos Receptores Histamínicos H1/administração & dosagem , Antagonistas dos Receptores Histamínicos H1/efeitos adversos , Humanos , Imidazóis/administração & dosagem , Metilprednisolona/administração & dosagem , Pessoa de Meia-Idade , Soluções Oftálmicas , Órbita/diagnóstico por imagem , Tomografia Computadorizada por Raios X
19.
Dermatitis ; 30(4): 243-246, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31313746

RESUMO

Linalool is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to linalool was considered rare because positive patch tests to it were infrequently observed. In recent years, however, it has been demonstrated that exposure of linalool to oxygen (air) results in formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound. By routine testing of patients suspected of having contact dermatitis with hydroperoxides of linalool, high frequencies of positive reactions were found, indicating these chemicals are important fragrance allergens. It should be realized, however, that a number of "positive" reactions may well be false-positive, irritant responses.


Assuntos
/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Perfumes/efeitos adversos , Feminino , Humanos , Masculino , Oxirredução , Testes do Emplastro
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