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1.
Allergol. immunopatol ; 48(1): 34-41, ene.-feb. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-186589

RESUMO

Background: Exposure to pets can be a predisposing factor in the development of certain diseases, including allergic diseases. Objective: We analyzed the role that exposure to indoor dogs and cats plays in the prevalence of allergic diseases. Methods: We examined the cross-sectional data of 1056 women and 936 men aged 15 to 18 years; these individuals were selected through stratified and cluster random sampling. We asked all participants about their exposure to indoor dogs and cats during the year that preceded our study. The prevalence of allergic diseases was determined through core questions taken from The International Study of Asthma and Allergies in Childhood questionnaire. Results: The prevalence was 12.7% (95% CI: 11.3%-14.2%) for asthma, 9.0% (95% CI: 7.8%-10.4%) for allergic rhinitis, and 5.2% (95% CI: 4.3%-6.2%) for atopic dermatitis. The multivariate analyses showed that exposure to indoor dogs, but not indoor cats, was associated with asthma prevalence (aOR 1.37; 95% CI: 1.03-1.83), as was male sex (aOR = 1.42; 95% CI: 1.08-1.86), a personal history of allergic rhinitis (aOR = 3.24; 95% CI: 2.25-4.66), and a maternal history of asthma (aOR = 3.06; 95% CI: 1.89-4.98). The population attributable risk for exposure to indoor dogs was 18%. Notably, neither allergic rhinitis nor atopic dermatitis was found to be associated with dog or cat exposure (p > 0.05). Conclusion: Exposure to dogs in late adolescence is a factor associated with asthma, although its contribution to the development of asthma should be investigated in new studies


No disponible


Assuntos
Humanos , Masculino , Feminino , Adolescente , Animais de Estimação , Asma/epidemiologia , Asma/etiologia , Rinite Alérgica/epidemiologia , Dermatite Atópica/epidemiologia , Exposição Ambiental , Cães , Estudos Transversais , Alergia e Imunologia , Análise Multivariada , Inquéritos e Questionários , Estudantes/estatística & dados numéricos , Razão de Chances , Modelos Logísticos
2.
Medicine (Baltimore) ; 99(2): e18565, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31914034

RESUMO

BACKGROUND: Atopic dermatitis (AD, atopic eczema) is a pruritic, inflammatory, chronic skin disease. Since there is limitation of conventional treatment of AD, traditional herbal medicine can be an attractive therapeutic option in patients having AD for a long time. So-Cheong-Ryong-Tang (SCRT) has been found to inhibit histamine release and degranulation of mast cells, differentiation of basophils, and proliferation of eosinophils. We designed this clinical trial to evaluate the efficacy and safety of SCRT as compared to placebo in patients with AD and respiratory disorders. METHODS/DESIGN: This study is a single-center, randomized, double-blind, placebo-controlled, and investigator-initiated clinical trial. A total of 60 patients between 7 and 65 years of age with AD and respiratory disorders who received a diagnosis of AD by Hanifin and Rajka criteria who scored 15 to 50 in a scoring atopic dermatitis (SCORAD) will be enrolled. Participants will be randomly assigned to the SCRT or placebo group in a ratio of 1:1 and they will have a visit schedule comprising 4 visits including a screening visit during 8 to 10 weeks. The participants will be administered SCRT or placebo 3 times a day for 4 weeks. The primary outcome will be measured by a change of the SCORAD index. The secondary outcomes will be measured by changes in the dose and frequency of usage of the AD ointment, dermatology life quality index scores, pruritus and sleep disorder in visual analog scale, skin moisture content, skin surface temperature, Hamilton anxiety rating scale scores, depression rating scale scores, stress/autonomic nervous function test, and attention deficit hyperactivity disorder survey scores at week 4 as compared to those at the baseline. DISCUSSION: To the best of our knowledge, SCRT has rarely been reported for dermatologic diseases. This will be the first clinical trial to assess the efficacy and safety of SCRT in patients with AD and respiratory disorders. We hope that the results of this trial will provide evidence for the use of SCRT as a new treatment for AD with respiratory disorders. TRIAL REGISTRATION: Korean National Clinical Trial Registry, Clinical Research Information Service. (KCT0004148) (https://cris.nih.go.kr/cris/search/search_result_st01_en.jsp?seq=14981<ype=&rtype=).


Assuntos
Dermatite Atópica/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Transtornos Respiratórios/tratamento farmacológico , Transtornos Respiratórios/epidemiologia , Adolescente , Adulto , Idoso , Criança , Depressão/epidemiologia , Dermatite Atópica/epidemiologia , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prurido/epidemiologia , Qualidade de Vida , Pele/fisiopatologia , Transtornos do Sono-Vigília/epidemiologia , Estresse Psicológico/epidemiologia , Adulto Jovem
3.
Environ Pollut ; 256: 113340, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31662257

RESUMO

BACKGROUND: Evidence of health effects following early life exposure to short-to-medium duration of high pollution levels is extremely limited. OBJECTIVES: We aimed to evaluate the associations between: 1. intrauterine exposure to fine particulate matter (PM2.5) from coal mine fire emissions and the frequencies of general practitioner attendances and dispensations of prescribed asthma inhalers, steroid skin creams, and antibiotics during the first year of life; 2. infant exposure and those outcomes during the year following the fire. METHODS: All participants were recruited from the Latrobe Valley of Victoria, Australia. Participants' 24-h average and hourly peak mine fire-specific PM2.5 exposures from 09/02/2014 to 31/03/2014 were estimated using chemical transport modelling. Outcome data were obtained from the Australian Medicare Benefits Schedule and Pharmaceutical Benefits Scheme from each child's birth to 31/12/2016. We used negative binomial and logistic regression models to independently assess risks of the outcomes associated with every 10 and 100 µg m-3 increase in average or peak PM2.5 exposure, respectively, while adjusting for potential confounders. RESULTS: We included 286 of 311 children whose parents consented to be linked, comprising 77 with no exposure, 88 with intrauterine exposure and 121 with exposure in infancy. 10- and 100- µg m-3 increases in average and peak PM2.5 exposure during infancy were associated with greater incidence of antibiotics being dispensed during the year following the fire: the adjusted incidence rate ratios were 1.24 (95% CI 1.02, 1.50, p = 0.036) and 1.14 (1.00, 1.31, p = 0.048) respectively. No other significant associations were observed. CONCLUSION: Exposure to coal mine fire emissions during infancy was associated with increased dispensing of antibiotics. This could reflect increased childhood infections or increased prescriptions of antibiotics in the year following the fire.


Assuntos
Poluição do Ar/análise , Asma/epidemiologia , Infecções Bacterianas/epidemiologia , Dermatite Atópica/epidemiologia , Uso de Medicamentos/estatística & dados numéricos , Exposição Ambiental/análise , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Poluentes Atmosféricos/análise , Asma/terapia , Infecções Bacterianas/terapia , Criança , Minas de Carvão , Dermatite Atópica/terapia , Prescrições de Medicamentos/estatística & dados numéricos , Feminino , Fogo , Humanos , Incidência , Lactente , Masculino , Material Particulado/análise , Gravidez , Efeitos Tardios da Exposição Pré-Natal/terapia , Fatores de Tempo , Vitória/epidemiologia
4.
Int Arch Allergy Immunol ; 181(1): 1-10, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31593946

RESUMO

In recent decades, the worldwide prevalence of allergic disease has increased considerably. The atopic march is a model aimed at explaining the apparent progression of allergic diseases from atopic dermatitis (AD) to allergic asthma (AA) and to allergic rhinitis (AR). It hypothesizes that allergic disease begins, typically in children, with the development of AD, then AA, and finally progresses to AR. This theory has been widely studied in cross-sectional and long-term longitudinal studies and it has been found that as prevalence of AD declines, prevalence of AA increases. A similar relationship is reported between AA and AR. The legitimacy of the atopic march model is, however, currently debated. Epidemiological evidence and criticism of longitudinal studies point to an overstatement of the atopic march's prevalence and incorrect mechanisms, opening a discussion for alternative models to better explain the pathophysiological and epidemiological processes that promote this progression of allergic diseases. Albeit, risk factors for the development and progression of allergic disease, particularly AD, are critical in identifying disease progression. Investigating the role of age, severity, family history, phenotype, and genetic traits may give a better indication into the progression of allergic diseases. In addition, studies following patients from infancy into adulthood and a general increase in longitudinal studies would help broaden the knowledge of allergic disease progression and the atopic march.


Assuntos
Alergia e Imunologia/tendências , Asma/epidemiologia , Dermatite Atópica/epidemiologia , Rinite Alérgica/epidemiologia , Adulto , Animais , Criança , Progressão da Doença , Medicina Baseada em Evidências , Humanos , Modelos Imunológicos , Prevalência
5.
J Drugs Dermatol ; 18(10): 1020-1027, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31584781

RESUMO

Introduction: Atopic dermatitis (AD) is a chronic, relapsing skin disease starting typically in atopic-prone children between 3­6 months of age, with most children having developed AD by the age of 5 years. Intense itching leads to sleep disturbance, especially in younger children and toddlers. This review explores early intervention in infants and young children with AD by controlling skin barrier function and inflammation at the earliest time point using a moisturizer and a proactive treatment. Methods: A working group of experienced clinicians managing pediatric populations with AD convened for a meeting. The panel reviewed the literature surrounding early intervention in infants and young children with AD and developed and discussed clinical questions aimed at optimizing clinical outcomes. Results: Complex gene/immune system/environment interactions are involved in AD development. Epidermal barrier defects play a central role in the condition, with various studies showing impairment of skin barrier function at birth may precede clinical AD. Dynamic changes take place in the amounts of skin lipids during infancy. Studies confirm that daily use of a moisturizer from birth onwards may offer benefits in improving skin barrier function and possibly prevention of AD, especially in high-risk, atopic prone newborns. Plant-based moisturizers were shown to be safe and effective when applied in pediatric patients with AD and may provide a TCS-sparing effect while improving skin condition. Conclusion: Dry skin conditions during infancy may predict the subsequent development of AD. Consequently, emollient therapy from birth represents a feasible, safe, and effective approach for AD prevention. Therefore, parental education and the application of moisturizers are recommended as an integral part of AD prevention, treatment, and maintenance. J Drugs Dermatol. 2019;18(10):1020-1027.


Assuntos
Dermatite Atópica/tratamento farmacológico , Emolientes/administração & dosagem , Carga Global da Doença , Extratos Vegetais/administração & dosagem , Fatores Etários , Idade de Início , Pré-Escolar , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Emolientes/efeitos adversos , Humanos , Incidência , Lactente , Recém-Nascido , Extratos Vegetais/efeitos adversos , Prevalência , Fatores de Risco
6.
Iran J Allergy Asthma Immunol ; 18(4): 347-357, 2019 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-31522443

RESUMO

Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. The aim of this review is to comprehensively summarize the various factors impacting AD incidence in offspring and provide guidance for primary prevention. Recent research has demonstrated that environmental and climate factors, maternal history of allergies, gestational diabetes, and stress play essential roles in increasing the risk of AD in infants. Some factors have protective effects against the incidence of AD, including probiotic supplementation, fish intake, and moisturizers. This review also considers fundamental research into AD prevalence and factors that in the past were mistakenly thought to affect that prevalence, such as caesarean section and antigen avoidance. The potential influence of these factors on infant AD incidence remains inconclusive and needs further study. Furthermore, infants with a family history of atopic disease may benefit from early weaning or reduced breastfeeding duration.


Assuntos
Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Suscetibilidade a Doenças , Exposição Materna , Efeitos Tardios da Exposição Pré-Natal , Dieta , Meio Ambiente , Feminino , Humanos , Hipótese da Higiene , Incidência , Nutrientes , Gravidez , Probióticos , Fatores de Risco
7.
Dermatol Online J ; 25(8)2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31553859

RESUMO

Atopic dermatitis (AD) is a common multifactorial skin disease occurring primarily in young children. AD has increased in prevalence over the past decades, but little knowledge exists on the prevalence of AD in adults. Herein, published estimates of the point-prevalence and one-year prevalence of AD in adults are reviewed in the context of various study characteristics such as the age and gender distribution of the populations, sampling methods, study design, and geographical area of origin. In total, 14 different population studies reporting the prevalence of AD in adults in 17 countries were identified. There was a substantial between-country variation in both the point-prevalence (1.6 to 11.5%) and one-year prevalence (2.2 to 17.6%) of AD with heterogeneity explained partly by gender, age, geography, study design, and diagnostic criteria.


Assuntos
Dermatite Atópica/epidemiologia , Adulto , Humanos , Prevalência
8.
Acta Med Port ; 32(9): 606-613, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31493365

RESUMO

With an increasing prevalence during the past decades, atopic dermatitis has become a global health issue. A literature search following a targeted approach was undertaken to perform this non-systematic review, which intends to provide an overview of the epidemiology, pathophysiology, clinical features, comorbidities, and current therapies for the treatment of atopic dermatitis. In sum, this is a heterogeneous skin disorder associated with variable morphology, distribution, and disease course. Although not completely understood, its pathogenesis is complex and seems to result from a combination of genetic and environmental factors that induce skin barrier dysfunction, cutaneous and systemic immune dysregulation, skin microbiota dysbiosis, and a strong genetic influence. Diagnosis is based on specific criteria that consider patient and family history and clinical manifestations. Overall disease severity must be determined by evaluating both objective signs and subjective symptoms. Therapeutic goals require a multistep approach, focusing on reducing pruritus and establishing disease control. Patients should be advised on basic skin care and avoidance of triggers. Topical anti-inflammatory agents should be considered in disease flares or chronic/recurrent lesions. In case of inadequate response, phototherapy, systemic immunosuppressants and, more recently, dupilumab, should be added. Nevertheless, the treatment of moderate-to-severe atopic dermatitis remains challenging and novel, efficacious, safe and targeted treatments are urgently needed. In conclusion, although the last few years have seen important improvement in the understanding of the disease, future research in atopic dermatitis will continue exploring gene-environment interactions and how it affects pathophysiology, disease severity, and treatment outcomes.


Assuntos
Dermatite Atópica , Fatores Etários , Comorbidade , Dermatite Atópica/diagnóstico , Dermatite Atópica/tratamento farmacológico , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Gerenciamento Clínico , Saúde da Família , Interação Gene-Ambiente , Humanos , Prevenção Primária/métodos , Qualidade de Vida , Índice de Gravidade de Doença
9.
J Pak Med Assoc ; 69(8): 1175-1180, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31431774

RESUMO

OBJECTIVE: To identify the prevalent skin disorders among primary school children, awareness of its risk factors and to assess the socio-demographic determinants associated with their development. METHODS: The cross-sectional observational study was conducted in September-December 2016 comprising children from six public and private schools in Wadi Al Dawaser region of Eastern Saudi Arabia. A self-generated self-administered questionnaire was sent through the children to be filled up by their parents. Details on sociodemographic and skin dermatoses conditions were collected. Data were analyzed using SPSS 16.. RESULTS: Of the 710 students approached, 499(70.2%) responded. Of them, 151(30.2%) were boys and 348(69.7%) were girls. The overall mean age was 10.3}1.4 years (range: 3-15 years). The overall prevalence of skin disorders was 118(23.6%). Allergic dermatoses 11(11.3%) and eczema 4(11.8%) were the commonest conditions. Lichen planus 6(5%), acne 9(7.6%), allergic rashes 4(3.3%), and psoriasis 3(2.5%) were also recorded. Sociodemographic and hygiene factors were significantly associated with the disease (p<0.05 each). CONCLUSIONS: A high prevalence of skin disorders was encountered among primary school children in the region studied.


Assuntos
Dermatopatias/epidemiologia , Acne Vulgar/epidemiologia , Adolescente , Animais , Criança , Pré-Escolar , Estudos Transversais , Dermatite Alérgica de Contato/epidemiologia , Dermatite Atópica/epidemiologia , Eczema/epidemiologia , Feminino , Humanos , Líquen Plano/epidemiologia , Masculino , Animais de Estimação , Prevalência , Arábia Saudita/epidemiologia , Dermatopatias Infecciosas/epidemiologia , Fatores Socioeconômicos , Vitiligo/epidemiologia
10.
J Autism Dev Disord ; 49(11): 4626-4633, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31435817

RESUMO

Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.


Assuntos
Transtorno do Espectro Autista/epidemiologia , Transtorno do Espectro Autista/genética , Dermatite Atópica/epidemiologia , Dermatite Atópica/genética , Vigilância da População , Irmãos , Adolescente , Asma/epidemiologia , Asma/genética , Asma/psicologia , Transtorno do Espectro Autista/psicologia , Criança , Estudos de Coortes , Dermatite Atópica/psicologia , Feminino , Humanos , Masculino , Fatores de Risco , Irmãos/psicologia , Taiwan/epidemiologia
11.
Medicine (Baltimore) ; 98(35): e16540, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464891

RESUMO

Antibiotics during infancy, delivery, and breastfeeding affect the intestinal microbiota in early life and is associated with allergic disease. Gastroenteritis (GE) during infancy also affects intestinal microbiota in early life, however, its relationship to allergic disease has not been investigated.Data of 45,499 males and 49,430 females, from birth to 5 years of age, were collected from a national database in Taiwan. Subjects were categorized into early GE (GE within 0-6 months) and non-early GE group (no GE within 0-6 months). The rates of asthma (AS), allergic rhinitis (AR), and atopic dermatitis (AD) over 5 years were evaluated and compared between the groups. In patients with AS, AR, and AD, the number of clinical visits and drug prescriptions for the allergic disease was also evaluated to assess the effect of early GE on allergic disease.After adjusting for the effect of GE in later life and other factors, the rates of AS [OR (odds ratio) 1.54, 95% confidence interval (CI) 1.48-1.60], AR [OR 1.49, 95% CI 1.45-1.54], and AD [OR 1.40, 95% CI 1.33-1.47] were higher in the early GE group than in the non-early GE group. The magnitude of the increase was higher in females than in males. In those with AS, AR, and AD, the number of clinical visits and drug prescriptions was not different between the early GE and non-early GE groups. In children with early GE, good control of GE in the following years lowered the rate of allergic disease.Early-life GE was associated with increased rates of AS, AR, and AD in later life and this was trend more prominent in females.


Assuntos
Asma/epidemiologia , Dermatite Atópica/epidemiologia , Gastroenterite/complicações , Rinite Alérgica/epidemiologia , Asma/etiologia , Estudos de Casos e Controles , Pré-Escolar , Dermatite Atópica/etiologia , Feminino , Gastroenterite/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Rinite Alérgica/etiologia , Caracteres Sexuais , Taiwan/epidemiologia
12.
Rev Peru Med Exp Salud Publica ; 36(2): 238-246, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31460635

RESUMO

OBJETIVE.: To assess whether exclusive breastfeeding is associated with atopic dermatitis in children under seven years of age. MATERIALS AND METHODS.: Non-paired case and control type study conducted in a third level of care hospital (Lambayeque Regional Hospital) between June 2016 and May 2018 in which 260 cases and 260 controls recruited in outpatient consultation of the Dermatology and Pediatrics services were evaluated. The UK criteria were used for the diagnosis of atopic dermatitis, as well as a survey with possible risk factors. RESULTS.: In the bivariate analysis, differences were found between cases and controls in relation to exclusive breastfeeding (p=0.001), family history of atopy (p<0.001), parents' educational level (p<0.001), smoking in the presence of the child (p=0.006), and origin (p=0.002). Exclusive breastfeeding was present in 93 (35.8%) of cases compared to 132 (50.8%) of controls. The multivariate analysis using logistic regression found that exclusive breastfeeding would have a protective effect on the presence of atopic dermatitis (OR= 0.62; 95% CI= 0.41-0.94) adjusted by age, sex, background, parents' educational level, initiation of complementary feeding, family member with atopy, and smoking habit. CONCLUSIONS.: Exclusive breastfeeding would have a protective effect on the appearance of atopic dermatitis in children under the age of seven.


Assuntos
Aleitamento Materno/estatística & dados numéricos , Dermatite Atópica/epidemiologia , Fumar/epidemiologia , Criança , Pré-Escolar , Saúde da Família , Feminino , Humanos , Lactente , Masculino , Fatores de Proteção , Estudos Retrospectivos , Fatores de Risco , Centros de Atenção Terciária
13.
Nutrients ; 11(8)2019 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-31405041

RESUMO

Research has investigated 25-hydroxyvitamin D (25(OH)D) levels in the Atopic Dermatitis (AD) population, as well as changes in AD severity after vitamin D (VitD) supplementation. We performed an up-to-date systematic review and meta-analysis of these findings. Electronic searches of MEDLINE, EMBASE and COCHRANE up to February 2018 were performed. Observational studies comparing 25(OH)D between AD patients and controls, as well as trials documenting baseline serum 25(OH)D levels and clinical severity by either SCORAD/EASI scores, were included. Of the 1085 articles retrieved, sixteen were included. A meta-analysis of eleven studies of AD patients vs. healthy controls (HC) found a mean difference of -14 nmol/L (95% CI -25 to -2) for all studies and -16 nmol/L (95% CI -31 to -1) for the paediatric studies alone. A meta-analysis of three VitD supplementation trials found lower SCORAD by -11 points (95% CI -13 to -9, p < 0.00001). This surpasses the Minimal Clinical Important Difference for AD of 9.0 points (by 22%). There were greater improvements in trials lasting three months and the mean weighted dose of all trials was 1500-1600 IU/daily. Overall, the AD population, especially the paediatric subset, may be at high-risk for lower serum 25(OH)D. Supplementation with around 1600 IU/daily results in a clinically meaningful AD severity reduction.


Assuntos
Dermatite Atópica/tratamento farmacológico , Suplementos Nutricionais , Deficiência de Vitamina D/tratamento farmacológico , Vitamina D/análogos & derivados , Vitamina D/uso terapêutico , Adolescente , Biomarcadores/sangue , Criança , Pré-Escolar , Dermatite Atópica/sangue , Dermatite Atópica/diagnóstico , Dermatite Atópica/epidemiologia , Suplementos Nutricionais/efeitos adversos , Feminino , Humanos , Incidência , Lactente , Masculino , Fatores de Risco , Índice de Gravidade de Doença , Resultado do Tratamento , Vitamina D/efeitos adversos , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/diagnóstico , Deficiência de Vitamina D/epidemiologia
14.
J Dermatol ; 46(10): 825-834, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31436343

RESUMO

Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. It is considered one of the most common chronic conditions, with an estimated global prevalence of nearly 230 million. As in the rest of the world, prevalence of atopic dermatitis has been increasing in Asian countries over the last few decades. This increased prevalence in Asian countries has been attributed to factors such as rapid urbanization, increasingly Westernized lifestyles, and improved standards of living and education. As a result, it is important to understand the increasing burden of disease in Asian countries and the differences between the countries in terms of epidemiology, diagnostic criteria, management, quality of life and economic burden.


Assuntos
Efeitos Psicossociais da Doença , Dermatite Atópica/epidemiologia , Qualidade de Vida , Ásia/epidemiologia , Dermatite Atópica/complicações , Dermatite Atópica/economia , Humanos , Estilo de Vida/etnologia , Prevalência , Fatores de Risco
15.
Allergol. immunopatol ; 47(4): 401-408, jul.-ago. 2019. graf, ilus
Artigo em Inglês | IBECS | ID: ibc-186512

RESUMO

The variety of foods and methods of preparation are part of the cultural identity of each population, and thus the main foods that cause symptoms vary among different regions. Due to their increasing frequency, Adverse Reactions to Food (AFR) have been the subject of extensive study, especially in North America and Europe but few studies have been conducted in other areas, especially in populations located in the tropics and subtropics. In this article, we review available information on the epidemiology of food sensitization and food allergies in tropical regions and explore the different epidemiological data considering the major food involved, the underlying immune mechanism and clinical symptoms partners. In addition, we identify the possible limitations and questions that arise from studies conducted in tropical countries, which helps to generate objectives for future research


No disponible


Assuntos
Humanos , Dermatite Atópica/epidemiologia , Hipersensibilidade Alimentar/epidemiologia , Clima Tropical , Alérgenos/imunologia , África/epidemiologia , Ásia/epidemiologia , Imunização , Imunoglobulina E/metabolismo , América Latina/epidemiologia , Prevalência
16.
Contact Dermatitis ; 81(4): 274-279, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31334857

RESUMO

BACKGROUND: Dental students are at high risk of developing adverse skin reactions following practical work during the dentistry degree program. They encounter multiple irritants and allergens that may cause skin reactions on exposed parts of the body, notably the hands. OBJECTIVES: To estimate the prevalence of skin reactions related to the pre-clinical and clinical training courses of the dentistry program and associated risk factors in Bulgarian dental students. METHOD: A cross-sectional study was performed using a self-report questionnaire. RESULTS: A total of 467 dental students completed the questionnaire (response 51.8%). The prevalence of self-reported skin symptoms was 21.2%. According to logistic regression analysis, the most important risk factors for work-related skin symptoms were a personal history of atopic dermatitis (odds ratio [OR] 3.92, 95% confidence interval [CI]: 1.99-7.72), allergic rhinoconjunctivitis and/or asthma (OR 1.94, 95%CI: 1.03-3.68), personal history of contact allergy (OR 2.19, 95%CI: 1.06-4.55), and hand washing >16 times a day (OR 2.42, 95%CI: 1.06-5.52). CONCLUSIONS: The results of this study suggest that work-related skin symptoms are frequent among dental students and indicate the need to establish effective primary preventive programs for occupational skin disorders at a national level.


Assuntos
Dermatite Ocupacional/epidemiologia , Dermatoses da Mão/epidemiologia , Exposição Ocupacional/estatística & dados numéricos , Estudantes de Odontologia/estatística & dados numéricos , Adulto , Asma/epidemiologia , Bulgária/epidemiologia , Conjuntivite Alérgica/epidemiologia , Dermatite Alérgica de Contato/epidemiologia , Dermatite Atópica/epidemiologia , Dermatite Ocupacional/etiologia , Feminino , Luvas Protetoras/estatística & dados numéricos , Dermatoses da Mão/etiologia , Desinfecção das Mãos , Humanos , Masculino , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/prevenção & controle , Prevalência , Rinite Alérgica/epidemiologia , Fatores de Risco , Autorrelato , Adulto Jovem
18.
Internist (Berl) ; 60(8): 792-798, 2019 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-31240339

RESUMO

Atopic dermatitis (AD) is one of the most frequent chronic inflammatory skin diseases, characterized by pruritic eczematous lesions. Due to the fact that AD is accompanied by signs of systemic inflammation and that an increased number of novel systemic treatment options are currently emerging, research into general medical comorbidities in moderately to severely affected AD patients has received great impetus in recent years. These studies have confirmed an increased risk of atopic diseases such as allergic asthma in AD patients. Furthermore, an association between AD and dermatological diseases with autoimmune pathophysiology such as vitiligo and alopecia areata has been demonstrated. Moreover, several studies have revealed an increased risk for internal autoimmune diseases in AD patients, e.g. inflammatory bowel disease and rheumatoid arthritis. A differentiated view of the data on AD as a possible risk factor for cardiovascular disease is needed. Large cross-sectional studies in the US revealed a correlation between AD and cardiovascular comorbidities. This has not been confirmed as yet in large German, Danish and Canadian investigations. Whether diverse "coping" strategies in different countries can explain these variances remains to be discussed. In terms of microbial comorbidities, AD patients display a particular susceptibility to viral infections.


Assuntos
Dermatite Atópica/patologia , Eczema/patologia , Asma/epidemiologia , Doenças Autoimunes/epidemiologia , Doenças Cardiovasculares/epidemiologia , Comorbidade , Dermatite Atópica/epidemiologia , Eczema/epidemiologia , Humanos , Viroses/epidemiologia
19.
Int J Occup Med Environ Health ; 32(3): 281-290, 2019 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-31180070

RESUMO

It is estimated that every third person living in Europe suffers from allergic diseases. Allergies are a growing health problem in Poland where 40% of the population have allergy symptoms, including 12% afflicted with asthma. The actual cost of allergic diseases is difficult to estimate due to the lack or incompleteness of the relevant data. The aim of this review is to present estimates of the indirect costs of allergic diseases in Poland and globally, using asthma, allergic rhinitis and atopic dermatitis as examples. The analysis also includes the impact of allergic diseases on the costs to the social welfare system and employers. The literature review of the indirect costs of allergic diseases shows that the indirect costs of a disease, which substantially exceed the direct costs, increase with the disease activity and severity. Interestingly, some studies have found that the indirect costs of lost productivity due to hours missed from work to take care of a sick child could be threefold higher than those of absence due to a worker's own illness. The indirect costs of a disease can be significantly reduced by early diagnosis and appropriate treatment. Int J Occup Med Environ Health. 2019;32(3):281-90.


Assuntos
Asma/economia , Efeitos Psicossociais da Doença , Dermatite Atópica/economia , Rinite Alérgica/economia , Absenteísmo , Asma/epidemiologia , Criança , Cuidado da Criança/economia , Dermatite Atópica/epidemiologia , Humanos , Presenteísmo , Qualidade de Vida , Rinite Alérgica/epidemiologia
20.
Aust Vet J ; 97(8): 262-267, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31209859

RESUMO

OBJECTIVE: To determine the lesion distribution patterns in different breeds of dogs affected by atopic dermatitis in South Australia. METHODS: The presence or absence of erythematous skin lesions in 267 cases of canine atopic dermatitis (CAD) was recorded across 36 anatomical sites. Breeds represented by ≥ 9 dogs were included in the analysis. The percentage of dogs showing lesions at each of the body sites was calculated and illustrated on colour-coded diagrams. Variations in affected body sites within and between breeds were compared using Kruskal-Wallis ANOVA and Dunn's multiple comparison tests. RESULTS: The prevalence of skin lesions at different body sites differed significantly both in the population as a whole and within breeds. The sites affected in ≥ 75% dogs were the dorsal and ventral aspects of the front and hind paws. The sites affected in 50-74% were the medial pinnae, axillae, ventral chest, abdomen and perineum. Sites affected in 25-49% of dogs included the face, periocular region and forelimb. Remaining body sites were affected in < 25% of dogs. Analysis at the breed level revealed some differences from this standard distribution pattern. CONCLUSION: The results of this study confirmed the typical lesion distributions seen in CAD and highlighted some subtle differences in breeds commonly seen in South Australia. This will be useful for clinical practitioners in prioritising differential diagnoses for pruritic skin conditions.


Assuntos
Dermatite Atópica/veterinária , Doenças do Cão/epidemiologia , Animais , Dermatite Atópica/epidemiologia , Doenças do Cão/patologia , Cães , Feminino , Masculino , Linhagem , Prevalência , Austrália do Sul/epidemiologia
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