Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.361
Filtrar
1.
Vet Clin North Am Food Anim Pract ; 36(3): 725-733, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33032702

RESUMO

Whether poisoned by grazing certain toxic plants, by eating contaminated feed, or by topical contact with plant toxins, certain plants poison livestock causing photosensitivity and dermatitis. These dermal lesions are rarely fatal, and with appropriate therapy and protection from additional exposure most lesions heal with few permanent sequelae. However, these lesions often result in costly production losses and missed opportunities. The objectives of this review are to briefly introduce toxic plants that result in photosensitivity and dermatitis, review the toxins and pathogenesis of plant-induced skin disease, and summarize treatments and recommendations to avoid poisoning.


Assuntos
Dermatite/veterinária , Gado , Transtornos de Fotossensibilidade/veterinária , Intoxicação por Plantas/veterinária , Plantas Tóxicas/envenenamento , Animais , Dermatite/etiologia , Transtornos de Fotossensibilidade/etiologia
4.
Dermatol Online J ; 26(4)2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32621682

RESUMO

A striking dermatitis referred to by its colloquial designation of sabra dermatitis is associated with glochidia inoculation from the Opuntia cactus commonly known as the prickly pear. We report a 45-year-old woman who had an unexpected encounter with a cactus plant during a trip to Texas. She brushed up against the plant and was aware that she had been inoculated with several spines of the plant. Five days later she developed erythematous papules on the digits accompanied by swelling. The biopsy showed a very striking granulomatous reaction pattern within the dermis. There was a linear pattern of necrobiosis, likely representing a tract of inoculation injury palisaded by histiocytes including multinucleated forms. This necrobiotic tract demonstrated retained glochidia, each measuring roughly 40 to 70 microns in diameter. The nature of the inflammatory response is one that combines features of classic delayed hypersensitivity and an innate foreign body response. The glochidia are capable of eliciting a T cell mediated immune response; it is reasonable to assume that a Th1 cytokine signal is responsible for the unique pattern of inflammation including the secondary influx of neutrophils and relative lack of tissue eosinophilia.


Assuntos
Dermatite/etiologia , Hipersensibilidade Tardia/etiologia , Opuntia/efeitos adversos , Dermatite/imunologia , Dermatite/patologia , Feminino , Humanos , Hipersensibilidade Tardia/diagnóstico , Hipersensibilidade Tardia/patologia , Pessoa de Meia-Idade
6.
BMC Infect Dis ; 20(1): 348, 2020 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-32414336

RESUMO

BACKGROUND: Besides the considerable role of blackflies to the transmission of many disease agents, these flies considered as annoying biting pests of wildlife, livestock, poultry, and humans. There are few literature reports of blackfly fever following Simulium spp. This study describes a case of blackfly fever and dermatitis following blackflies numerous bites in Iran. CASE PRESENTATION: The present report describes a 25-year-old man that was attacked by numerous flies while fishing and camping near Namrood river in Firuzkuh County, Tehran Province, Iran. Pruritic dermatitis with marked edema appeared mainly on the hands and legs and subsequently, the patient's condition worsened with swollen lymph nodes, joints aching, and 40 °C fever. The patient's clinical signs and symptoms were alleviated by injection of intramuscular Dexamethasone Phosphate (DEXADIC®) 8 mg/2 ml after 24 h. CONCLUSIONS: This study reported a human case with blackfly fever and dermatitis following numerous bites of Simulium kiritshenkoi, for the first time in Iran.


Assuntos
Dermatite/etiologia , Febre/etiologia , Mordeduras e Picadas de Insetos/complicações , Simuliidae , Adulto , Animais , Dermatite/tratamento farmacológico , Dexametasona/análogos & derivados , Dexametasona/uso terapêutico , Edema/tratamento farmacológico , Edema/etiologia , Feminino , Mãos , Humanos , Mordeduras e Picadas de Insetos/tratamento farmacológico , Irã (Geográfico) , Perna (Membro) , Masculino , Simuliidae/anatomia & histologia , Simuliidae/fisiologia
7.
Clin Dermatol ; 38(1): 63-78, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32197750

RESUMO

A red swollen face can be a skin sign of a potentially life-threatening condition. We present in detail the main clinical presentations, diagnostic tests, and management of some of the most severe conditions that can frequently present as a red and swollen face: acute or recurrent angioedema, mast cell-driven or bradykinin-mediated angioedema, nonhereditary and hereditary angioedema, allergic or photoallergic facial contact dermatitis, contact urticaria, severe adverse drug reactions (particularly drug reaction with eosinophilia and systemic symptoms [DRESS]), skin infections (erysipelas, cellulitis, necrotizing fasciitis), and autoimmune diseases (dermatomyositis). There are many other conditions that also have to be considered in the differential diagnosis of a red swollen face.


Assuntos
Dermatite/patologia , Exantema/etiologia , Exantema/patologia , Face/patologia , Angioedema/etiologia , Angioedema/patologia , Dermatite/etiologia , Dermatomicoses/etiologia , Dermatomicoses/patologia , Erupção por Droga/etiologia , Erupção por Droga/patologia , Humanos
9.
Sci Rep ; 10(1): 4493, 2020 03 11.
Artigo em Inglês | MEDLINE | ID: mdl-32161331

RESUMO

Nintedanib, a receptor tyrosine kinase (RTK) inhibitor has been developed as therapeutics for idiopathic pulmonary fibrosis and non-small lung cancer. We found that the expression levels of RTK, especially VEGFR1 is increased in skin biopsies of dermatitis patients from multiple independent datasets. Moreover, VEGFR1 is highly expressed by infiltrated cells in dermis from oxazolone (OXA) treated mice. Interestingly, nintedanib alleviates dermatitis symptom in OXA-induced animal model. Especially, levels of epidermis thickness, infiltrated immune cells including mast cells and eosinophils were decreased from mice cotreated with nintedanib and OXA compared with OXA treated mice. Moreover, serum IgE and Th2 cytokines including IL-4 and IL-13 were decreased by nintedanib treatment. These results suggest an evidence that nintedanib alleviates animal model of dermatitis.


Assuntos
Dermatite/tratamento farmacológico , Dermatite/metabolismo , Indóis/farmacologia , Inibidores de Proteínas Quinases/farmacologia , Animais , Biomarcadores , Biópsia , Linhagem Celular , Sobrevivência Celular , Dermatite/etiologia , Dermatite/patologia , Modelos Animais de Doenças , Ensaio de Imunoadsorção Enzimática , Expressão Gênica , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Camundongos , Oxazolona/efeitos adversos , Pele/efeitos dos fármacos , Pele/metabolismo , Pele/patologia , Receptor 1 de Fatores de Crescimento do Endotélio Vascular/genética , Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo
10.
Pesqui. vet. bras ; 40(1): 1-6, Jan. 2020. ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1091656

RESUMO

The aim of this work was to describe the epidemiological, clinical and pathological aspects of two outbreaks of spontaneous poisoning caused by Froelichia humboldtiana in cattle in Pernambuco, northeastern Brazil and reproduce experimentally this poisoning in cattle. Spontaneous poisonings of primary photosensitization occurred in two farms at the municipalities of Cachoeirinha and São Caetano and affected twenty-two adult bovines and two suckling calves after the rainy season. All bovines have recovered 21 days after they were removed from the pasture. To reproduce experimental poisoning, three cows and a calf were maintained in a pasture with 1ha composed by F. humboldtiana during 14 days. Clinical signs and skin lesions were similar in both spontaneous and experimental poisoning and consisted of cutaneous itching and hyperemia of non-pigmented areas of skin that evolved into edema, exudative dermatitis and extensive areas of skin necrosis. Serum levels of aspartate aminotransferase (AST), gamma glutamyltransferase (GGT), total, direct and indirect bilirubin were normal in all cattle examined. Histologically, lesions consisted of epidermal necrosis, hyperkeratosis with large amounts of degenerate neutrophils and acanthosis. In the dermis, edema and inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells mainly around the blood vessels were observed. In the experimental group, clinical signs of photosensitization were observed after the third day of F. humboldtiana consumption. The suckling calf displayed mild clinical signs of photodermatitis on the 8th day of the experiment. It was estimated that the average consumption of F. humboldtiana necessary to initiate clinical signs in each adult bovine was 78kg.(AU)


Os objetivos deste trabalho foram descrever os aspectos epidemiológicos, clínicos e patológicos de dois surtos de intoxicação por Froelichia humboldtiana em bovinos em Pernambuco e reproduzir experimentalmente essa intoxicação em bovinos. Intoxicações espontâneas foram observadas após o início do período chuvoso nos municípios de Cachoerinha e São Caetano. Vinte e dois bovinos apresentaram sinais clínicos e lesões cutâneas compatíveis com fotossensibilização primária, dentre os quais, dois bezerros lactentes. Todos os bovinos se recuperaram totalmente cerca de 21 dias após serem retirados da pastagem. Para reproduzir experimentalmente a intoxicação, três vacas, uma delas com bezerro ao pé, foram mantidas em um piquete de 1ha composto por F. humboldtiana por 14 dias consecutivos. O quadro clínico e as lesões tegumentares, tanto nos bovinos intoxicados nos surtos espontâneos, quanto nos bovinos do experimento consistiram em prurido e hiperemia em áreas despigmentadas de pele, que evoluíam para edema, dermatite exsudativa e necrose de áreas extensas de pele. Em todos os bovinos examinados, os níveis séricos de aspartato aminotransferase (AST), gamaglutamiltransferase (GGT), bilirrubina total, direta e indireta estavam normais. Histologicamente, as lesões consistiram em necrose da epiderme, hiperqueratose com grande quantidade de neutrófilos degenerados e acantose. Na derme havia edema e infiltrado inflamatório composto por eosinófilos, linfócitos e plasmócitos principalmente ao redor dos vasos sanguíneos. Nos bovinos do experimento, sinais clínicos de fotossensibilização foram observados após o terceiro dia de consumo de F. humboldtiana. O bezerro lactente apresentou sinais clínicos leves de fotodermatite no 8º dia do experimento. Estimou-se que o consumo médio de matéria seca de F. humboldtiana necessário para iniciar os sinais clínicos em cada bovino adulto foi de 78kg.(AU)


Assuntos
Animais , Bovinos , Intoxicação por Plantas/veterinária , Dermatite Fotoalérgica/etiologia , Cicer/envenenamento , Cicer/toxicidade , Dermatite Fotoalérgica/veterinária , Dermatite/etiologia , Dermatite/veterinária
11.
Prev Vet Med ; 175: 104875, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31896502

RESUMO

Pododermatitis is a chronic and progressive bacterial infectious disease of birds´ footpads, especially associated with captivity, which could represent an important problem in wildlife rehabilitation centres, delaying the release of the birds to the environment and harming their conservation. The objectives of the present study were i) to estimate the incidence rate of pododermatitis, ii) to analyse the influence of environmental, physiological, and pathological factors which may influence the onset of the infection in raptors after their admission to a rehabilitation centre, and iii) to follow up the evolution and macroscopic characteristics of the lesion. An observational retrospective study was carried out on clinical cases of raptors (n = 2004) admitted in a rehabilitation centre in central Spain from 2009 to 2015. The proportion of pododermatitis was 6.9%, with an incidence density of 6.8 cases/100 bird-years at risk. Our results showed that the disease was more likely to occur in birds staying longer (P < 0.001). According to Cox analysis, the variables 'raptor family' (P < 0.001) and 'age' (P = 0.002) may have significant effects on pododermatitis development. Raptors from the Falconidae and Strigidae families were less likely to develop pododermatitis than those from the Accipitridae family, with a hazard ratio (HR) of 0.31 and 0.13, respectively. Regarding age, fully feathered raptors had a three-fold higher risk of having pododermatitis than non-fully feathered birds. Survival analysis of time of pododermatitis development revealed significant differences associated with the variables 'raptor family' (P < 0.03); 'age' (P < 0.001) and 'cause of admission' (P = 0.001). Duration of the pathology (P < 0.05) and lesion location (P < 0.001) seemed to be phylogenetic dependent. Injuries were primarily located in the toes area or the whole footpad of birds belonging to the Accipitridae or Falconidae families, respectively (P = 0.003).


Assuntos
Doenças das Aves/epidemiologia , Dermatite/veterinária , Doenças do Pé/veterinária , Aves Predatórias , Animais , Doenças das Aves/etiologia , Dermatite/epidemiologia , Dermatite/etiologia , Doenças do Pé/epidemiologia , Doenças do Pé/etiologia , Incidência , Espanha/epidemiologia
12.
Animal ; 14(1): 138-149, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31280755

RESUMO

Little is known about the implications of accessing an outdoor range for broiler chicken welfare, particularly in relation to the distance ranged from the shed. Therefore, we monitored individual ranging behaviour of commercial free-range broiler chickens and identified relationships with welfare indicators. The individual ranging behaviour of 305 mixed-sex Ross 308 broiler chickens was tracked on a commercial farm from the second day of range access to slaughter age (from 16 to 42 days of age) by radio frequency identification (RFID) technology. The radio frequency identification antennas were placed at pop-holes and on the range at 2.7 and 11.2 m from the home shed to determine the total number of range visits and the distance ranged from the shed. Chickens were categorised into close-ranging (CR) or distant-ranging (DR) categories based on the frequency of visits less than or greater than 2.7 m from the home shed, respectively. Half of the tracked chickens (n=153) were weighed at 7 days of age, and from 14 days of age their body weight, foot pad dermatitis (FPD), hock burn (HB) and gait scores were assessed weekly. The remaining tracked chickens (n=152) were assessed for fear and stress responses before (12 days of age) and after range access was provided (45 days of age) by quantifying their plasma corticosterone response to capture and 12 min confinement in a transport crate followed by behavioural fear responses to a tonic immobility (TI) test. Distant-ranging chickens could be predicted based on lighter BW at 7 and 14 days of age (P=0.05), that is before range access was first provided. After range access was provided, DR chickens weighed less every week (P=0.001), had better gait scores (P=0.01) and reduced corticosterone response to handling and confinement (P<0.05) compared to CR chickens. Longer and more frequent range visits were correlated with the number of visits further from the shed (P<0.01); hence distant ranging was correlated with the amount of range access, and consequently the relationships between ranging frequency, duration and distance were strong. These relationships indicate that longer, more frequent and greater ranging from the home shed was associated with improved welfare. Further research is required to identify whether these relationships between ranging behaviour and welfare are causal.


Assuntos
Criação de Animais Domésticos/métodos , Bem-Estar do Animal , Galinhas , Dermatite/veterinária , Movimento , Doenças das Aves Domésticas/epidemiologia , Animais , Dermatite/epidemiologia , Dermatite/etiologia , Comportamento Alimentar , Feminino , Masculino , Doenças das Aves Domésticas/etiologia , Dispositivo de Identificação por Radiofrequência
13.
Hautarzt ; 71(1): 46-52, 2020 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-31538217

RESUMO

Incontinence-associated dermatitis (IAD) describes damage to the skin caused by repeated and prolonged contact with urine and/or feces. Patients of all ages can be affected; the diagnosis is preferably used in adults and adolescents. The predilection sites are perineal, perianal, the inner thighs and the convex areas of the buttocks. Increased moisture on the skin surface, increased pH, occlusion, feces digestive enzymes and repeated skin cleansing procedures are pathophysiologically relevant factors. Typical clinical signs of IAD are erythema, erosions, excoriations and pain. Diagnosis is often difficult because there are many relevant differential diagnoses, some of which may occur together with an IAD. In particular, pressure ulcer, contact dermatitis and intertrigo need to be differentiated and treated. Effective strategies of prevention and therapy of IAD are continence management, the use of efficient, absorbent products as well as consistent skin protection and care. IAD is a skin disease that is often not or incorrectly diagnosed. It should be treated as early as possible, together with the causative factors such a fecal and/or urinary incontinence, as otherwise it can lead to an unnecessarily long duration and severity of the symptoms.


Assuntos
Dermatite , Incontinência Fecal , Incontinência Urinária , Adolescente , Adulto , Dermatite/etiologia , Incontinência Fecal/complicações , Humanos , Pele , Higiene da Pele , Incontinência Urinária/complicações
14.
Am J Emerg Med ; 38(2): 412.e1-412.e2, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31864870

RESUMO

Shiitake dermatitis is a rare adverse cutaneous reaction to the ingestion of raw or undercooked shiitake mushrooms (Lentinula edodes). We report the case of a patient who developed a striking linear flagellate dermatitis without urticaria three days after returning from a trip from Tokyo where he had eaten shiitake mushrooms. The rash resolved after two weeks with topical corticosteroids and antihistamines given for symptomatic relief. Shiitake dermatitis is thought to be either a toxic or hypersensitivity reaction to lentinan, a heat-inactivated polysaccharide found in the cell walls of shiitake mushrooms. Although this mushroom is widely consumed in Eastern Asia, with the increasing globalisation of cuisine and travel, cases are likely to become more common in the Western world.


Assuntos
Dermatite/etiologia , Hipersensibilidade Alimentar/etiologia , Lentinano/efeitos adversos , Cogumelos Shiitake/química , Administração Tópica , Corticosteroides/administração & dosagem , Dermatite/tratamento farmacológico , Antagonistas dos Receptores Histamínicos/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Pele/patologia , Viagem
15.
Ultrason Sonochem ; 61: 104803, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31670253

RESUMO

Silk fibroin, which is derived from sericin through degumming, is mainly used as a biomaterial. However, interest in functional verification and industrial applications of sericin has been growing for several years. We used ultrasonication to simplify the extraction process of the silk peptide under low salt conditions at 20 °C, instead of using the conventional conditions of high salt and temperature. The concentration of the silk peptide was measured to determine the optimized extraction time and solvent, which were 4 h and 0.1 N NaOH, respectively. The molecular weight of the enzyme-treated silk peptide was measured using SDS-PAGE and GPC. Silk peptide treated with papain after ultrasound had a molecular weight of less than 5 kDa, and the papain treated-silk peptide reduced solar ultraviolet-induced COX-2 expression through inhibition of ERK phosphorylation. This is the first study investigating simultaneous extraction of fibroin and sericin, which can be used for mass production of food materials.


Assuntos
Dermatite/prevenção & controle , Fibroínas/biossíntese , Papaína/uso terapêutico , Luz Solar/efeitos adversos , Ondas Ultrassônicas , Animais , Bombyx , Dermatite/etiologia
16.
Rev Infirm ; 68(256): 30-31, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31870476

RESUMO

Dressings are a real challenge in the care of patients with thermal burns. They help to heal and prevent or treat possible skin infections. Paramedical teams must have a perfect strategy for organizing, managing pain and optimizing hygiene and asepsis rules. The purpose is to facilitate the understanding and implementation of this treatment by suggesting protocols that can be applied by all. It remains essential to mobilize specialized services to promote the evolution of burns.


Assuntos
Bandagens , Queimaduras , Adulto , Queimaduras/complicações , Queimaduras/terapia , Dermatite/etiologia , Humanos , Dor , Cicatrização
17.
Skinmed ; 17(5): 329-332, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31782708

RESUMO

Case 1: A 17-year-old white man was referred for evaluation of biopsy-proven patch-stage mycosis fungoides (MF) that had first appeared 5 years previously. Asymptomatic "bruises" had appeared under his football padding in a waistband distribution, and these lesions improved during each offseason but never fully resolved. His exposure history was only positive for swimming pool water and his athletic pads. On physical examination, large, irregular, geometric tan-colored patches were present along his waistband area, in areas of contact with his football padding, with an involved body surface area (BSA) of 23.7% (Figure 1A). Examination of scale for fungal hyphae under potassium hydroxide was negative. No lymphadenopathy was present.


Assuntos
Micose Fungoide/diagnóstico , Micose Fungoide/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Abdome , Adolescente , Adulto , Idoso , Dermatite/etiologia , Eritema/etiologia , Humanos , Masculino , Micose Fungoide/complicações , Estadiamento de Neoplasias , Transtornos da Pigmentação/etiologia , Neoplasias Cutâneas/complicações
20.
Int J Mol Sci ; 20(23)2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31775224

RESUMO

The therapeutic application of antimicrobial peptides (AMPs), a potential type of peptide-based biomaterial, is impeded by their poor antimicrobial activity and potential cytotoxicity as a lack of understanding of their structure-activity relationships. In order to comprehensively enhance the antibacterial and clinical application potency of AMPs, a rational approach was applied to design amphiphilic peptides, including head-to-tail cyclic, linear and D-proline antimicrobial peptides using the template (IR)nP(IR)nP (n = 1, 2 and 3). Results showed that these amphiphilic peptides demonstrated antimicrobial activity in a size-dependent manner and that cyclic peptide OIR3, which contained three repeating units (IR)3, had greater antimicrobial potency and cell selectivity than liner peptide IR3, DIR3 with D-Pro and gramicidin S (GS). Surface plasmon resonance and endotoxin neutralization assays indicated that OIR3 had significant endotoxin neutralization capabilities, which suggested that the effects of OIR3 were mediated by binding to lipopolysaccharides (LPS). Using fluorescence spectrometry and electron microscopy, we found that OIR3 strongly promoted membrane disruption and thereby induced cell lysis. In addition, an LPS-induced inflammation assay showed that OIR3 inhibited the pro-inflammatory factor TNF-α in RAW264.7 cells. OIR3 was able to reduce oxazolone-induced skin inflammation in allergic dermatitis mouse model via the inhibition of TNF-α, IL-1ß and IL-6 mRNA expression. Collectively, the engineered head-to-tail cyclic peptide OIR3 was considerable potential candidate for use as a clinical therapeutic for the treatment of bacterial infections and skin inflammation.


Assuntos
Antibacterianos/farmacologia , Anti-Inflamatórios/farmacologia , Materiais Biocompatíveis/farmacologia , Dermatite/tratamento farmacológico , Peptídeos Cíclicos/farmacologia , Adjuvantes Imunológicos/toxicidade , Animais , Antibacterianos/química , Anti-Inflamatórios/química , Peptídeos Catiônicos Antimicrobianos/química , Peptídeos Catiônicos Antimicrobianos/farmacologia , Materiais Biocompatíveis/química , Morte Celular , Dermatite/etiologia , Dermatite/patologia , Endotoxinas/farmacologia , Hemólise/efeitos dos fármacos , Humanos , Lipopolissacarídeos/farmacologia , Masculino , Camundongos , Camundongos Endogâmicos ICR , Oxazolona/toxicidade , Peptídeos/química , Peptídeos/farmacologia , Peptídeos Cíclicos/química , Células RAW 264.7
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA