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1.
Hautarzt ; 71(5): 333-341, 2020 May.
Artigo em Alemão | MEDLINE | ID: mdl-32333042

RESUMO

Autoinflammation leads to inflammation that mostly occurs without any clinically obvious reason. It can be so severe that organ damage with relevant tissue damage occurs. Inflammasomes are the drivers of autoinflammation. Although IL­1 beta and the inflammasomes as its critical regulators are very important in autoinflammation, not all patients respond to inhibition of this signalling pathway. Several autoinflammatory diseases were associated with mutations in proteasome-immunoproteasome components. Autoinflammatory diseases caused by highly relevant genetic variants are mostly hereditary. Usually in childhood but not always. The coming years will show whether inflammatory dermatoses will be increasingly treated with suppression of the innate immune system in addition to inhibition of adaptive immunity.


Assuntos
Dermatite/fisiopatologia , Doenças Hereditárias Autoinflamatórias/fisiopatologia , Dermatopatias/fisiopatologia , Criança , Humanos , Imunidade Inata , Inflamassomos , Inflamação
2.
Eur J Endocrinol ; 182(3): C9-C12, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31972544

RESUMO

Primary adrenal insufficiency (PAI) in children is mostly due to genetic defects. The understanding of the molecular genetics of the causes of adrenal insufficiency in the pediatric population has made significant progress during the last years. It has been shown that inherited PAI can lead to certain clinical manifestations and health problems in children beyond the adrenals. Organ dysfunctions associated with different forms of PAI in children include a wide range of organs such as gonads, brain, heart, bone, growth, bone marrow, kidney, skin, parathyroid, and thyroid. Diagnosing the correct genetic cause of PAI in children is therefore crucial to adequately control long-term treatment and follow-up in such patients.


Assuntos
Doença de Addison/genética , Hiperplasia Suprarrenal Congênita/genética , Doença de Addison/complicações , Doença de Addison/diagnóstico , Doença de Addison/fisiopatologia , Hiperplasia Suprarrenal Congênita/complicações , Hiperplasia Suprarrenal Congênita/diagnóstico , Hiperplasia Suprarrenal Congênita/fisiopatologia , Doenças do Desenvolvimento Ósseo/etiologia , Doenças do Desenvolvimento Ósseo/genética , Doenças do Desenvolvimento Ósseo/fisiopatologia , Encefalopatias/etiologia , Encefalopatias/genética , Encefalopatias/fisiopatologia , Cardiomiopatias/etiologia , Cardiomiopatias/genética , Cardiomiopatias/fisiopatologia , Transtornos do Desenvolvimento Sexual/etiologia , Transtornos do Desenvolvimento Sexual/genética , Transtornos do Desenvolvimento Sexual/fisiopatologia , Transtornos do Crescimento/etiologia , Transtornos do Crescimento/genética , Transtornos do Crescimento/fisiopatologia , Humanos , Hipoadrenocorticismo Familiar/complicações , Hipoadrenocorticismo Familiar/diagnóstico , Hipoadrenocorticismo Familiar/genética , Hipoadrenocorticismo Familiar/fisiopatologia , Síndromes de Imunodeficiência/etiologia , Síndromes de Imunodeficiência/genética , Síndromes de Imunodeficiência/fisiopatologia , Técnicas de Diagnóstico Molecular , Síndrome Nefrótica/etiologia , Síndrome Nefrótica/genética , Síndrome Nefrótica/fisiopatologia , Dermatopatias/etiologia , Dermatopatias/genética , Dermatopatias/fisiopatologia
4.
Medicina (B Aires) ; 79(Spec 6/1): 564-569, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31864227

RESUMO

In recent times, our understanding of the role of the immune system in different physiopathological situations has increased markedly. A new set of cells, generically known as innate lymphoid cells (ILC), has been discovered in the lymphoid compartment. Five ILC subsets can be recognized according to phenotypic and functional similarities with different subpopulations of T lymphocytes. Unlike T and B lymphocytes, ILC do not express antigen receptors nor undergo selection and clonal expansion upon activation. Instead, they respond rapidly to cytokines and danger signals in infected or inflamed tissues, producing cytokines that direct the immune response toward a type suitable for controlling the initial insult. In addition, ILC establish a crosstalk with other cells of the microenvironment that contributes to the maintenance and restoration of tissue homeostasis. Although many evidences on ILC were obtained from animal models, solid data confirm their existence in humans and their role in various inflammatory disorders. In this article, we address new knowledge on ILC, particularly on their role in the homeostasis of the immune system and in various inflammatory pathologies, in order to present new actors regulating immunity and immunopathology and affecting human health.


Assuntos
Homeostase/imunologia , Imunidade Inata/imunologia , Inflamação/imunologia , Enteropatias/imunologia , Pneumopatias/imunologia , Linfócitos/imunologia , Dermatopatias/imunologia , Homeostase/fisiologia , Humanos , Inflamação/fisiopatologia , Enteropatias/fisiopatologia , Pneumopatias/fisiopatologia , Dermatopatias/fisiopatologia
5.
J Physiol Pharmacol ; 70(3)2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31539880

RESUMO

The local renin-angiotensin-aldosterone system (RAAS) is fully expressed in the human skin at the mRNA and protein level. Local RAAS is known to play a regulatory function in epidermal proliferation, wound healing, scarring, cutaneous heating adaptation, and aging. There are also some indications of its role in the regulation of hair growth and sebum secretion. Impaired wound healing, skin diseases associated with diabetes, cancer development, psoriasis, and scleroderma may be related to changes in skin RAAS activity. Extensive research has shown that RAAS-modulating drugs can affect the skin when applied orally or topically, creating new therapeutic approaches against dermatological diseases.


Assuntos
Aldosterona/metabolismo , Sistema Renina-Angiotensina/fisiologia , Dermatopatias/fisiopatologia , Pele/fisiopatologia , Animais , Humanos , Fenômenos Fisiológicos da Pele
6.
Ann Dermatol Venereol ; 146(8-9): 585-591, 2019 Sep.
Artigo em Francês | MEDLINE | ID: mdl-31320184

RESUMO

Sensitive skin (or reactive skin) is defined as a syndrome involving the onset of unpleasant sensations (stinging sensation, burning sensation, pain, pruritus, tingling) in response to stimuli that do not normally produce such sensations. These unpleasant sensations cannot be accounted for by lesions attributable to any specific skin disease. The skin may appear normal or erythema may be present. Sensitive skin can occur on any part of the skin but particularly affects the face. Sensitive skin is very common and affects around half of the population to different degrees. The diagnosis is based primarily on clinical examination. The physiopathology of the condition is becoming better known: it appears to be caused by hyperreactivity of the cutaneous nervous system and is associated in particular with activation of sensorial proteins present on keratinocytes and nerve endings. However, there is still no consensus regarding treatment.


Assuntos
Dor , Parestesia , Prurido , Dermatopatias , Humanos , Dor/diagnóstico , Dor/etiologia , Dor/fisiopatologia , Parestesia/diagnóstico , Parestesia/etiologia , Parestesia/fisiopatologia , Prurido/diagnóstico , Prurido/etiologia , Prurido/fisiopatologia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Dermatopatias/fisiopatologia
7.
Dermatology ; 235(5): 380-389, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31269494

RESUMO

Autophagy, or self-eating, is an evolutionarily conserved process in which cytosol and organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for the degradation and recycling of cytoplasmic components in eukaryotes. It is well recognized that autophagy plays an important role in maintaining cellular homeostasis under physiological and pathophysiological con-ditions and the upregulation of autophagy may serve as an adaptive process to provide nutrients and energy when under stresses. Recently, studies have illustrated that autophagy is intricately related to skin diseases. This review provides a brief synopsis of the process of autophagy and aims to elucidate the roles of autophagy in different skin diseases and to highlight the need for increased research in the field.


Assuntos
Autofagia/fisiologia , Dermatopatias/fisiopatologia , Humanos
8.
Cutis ; 103(6): 329-332, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31348457

RESUMO

Recent changes to military medicine precipitated by the National Defense Authorization Act for Fiscal Year 2017 are expected to result in civilian specialists playing a larger role in the care of our military population. Medical readiness and deployment eligibility should be taken into consideration when establishing a treatment plan for service members. This article highlights unique factors civilian dermatologists must consider when treating active-duty military patients with acne, atopic dermatitis (AD), psoriasis, dissecting cellulitis of the scalp (DCS), and lupus erythematosus (LE).


Assuntos
Medicina Militar , Militares , Dermatopatias/terapia , Dermatologistas/organização & administração , Humanos , Dermatopatias/fisiopatologia , Estados Unidos
10.
Genes (Basel) ; 10(6)2019 06 10.
Artigo em Inglês | MEDLINE | ID: mdl-31185693

RESUMO

FBN1 encodes fibrillin 1, a key structural component of the extracellular matrix, and its variants are associated with a wide range of hereditary connective tissues disorders, such as Marfan syndrome (MFS) and mitral valve-aorta-skeleton-skin (MASS) syndrome. Interpretations of the genomic data and possible genotype-phenotype correlations in FBN1 are complicated by the high rate of intronic variants of unknown significance. Here, we report two unrelated individuals with the FBN1 deep intronic variants c.6872-24T>A and c.7571-12T>A, clinically associated with MFS and MASS syndrome, respectively. The individual carrying the c.6872-24T>A variant is positive for aortic disease. Both individuals lacked ectopia lentis. In silico analysis and subsequent mRNA study by RT-PCR demonstrated the effect of the identified variant on the splicing process in both cases. The c.6872-24T>A and c.7571-12T>A variants generate the retention of intronic nucleotides and lead to the introduction of a premature stop codon. This study enlarges the mutation spectrum of FBN1 and points out the importance of intronic sequence analysis and the need for integrative functional studies in FBN1 diagnostics.


Assuntos
Fibrilina-1/genética , Predisposição Genética para Doença , Síndrome de Marfan/genética , Prolapso da Valva Mitral/genética , Miopia/genética , Dermatopatias/genética , Adulto , Processamento Alternativo/genética , Tecido Conjuntivo/metabolismo , Tecido Conjuntivo/patologia , Matriz Extracelular/genética , Feminino , Genótipo , Humanos , Íntrons/genética , Masculino , Síndrome de Marfan/fisiopatologia , Pessoa de Meia-Idade , Prolapso da Valva Mitral/fisiopatologia , Mutação/genética , Miopia/fisiopatologia , Dermatopatias/fisiopatologia
11.
Oxid Med Cell Longev ; 2019: 2304018, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31178954

RESUMO

Angiogenesis is the process of new vessel formation, which sprouts from preexisting vessels. This process is highly complex and primarily involves several key steps, including stimulation of endothelial cells by growth factors, degradation of the extracellular matrix by proteolytic enzymes, migration and proliferation of endothelial cells, and capillary tube formation. Currently, it is considered that multiple cytokines play a vital role in this process, which consist of proangiogenic factors (e.g., vascular endothelial growth factor, fibroblast growth factors, and angiopoietins) and antiangiogenic factors (e.g., endostatin, thrombospondin, and angiostatin). Angiogenesis is essential for most physiological events, such as body growth and development, tissue repair, and wound healing. However, uncontrolled neovascularization may contribute to angiogenic disorders. In physiological conditions, the above promoters and inhibitors function in a coordinated way to induce and sustain angiogenesis within a limited period of time. Conversely, the imbalance between proangiogenic and antiangiogenic factors could cause pathological angiogenesis and trigger several diseases. With insights into the molecular mechanisms of angiogenesis, increasing reports have shown that a close relationship exists between angiogenesis and oxidative stress (OS) in both physiological and pathological conditions. OS, an imbalance between prooxidant and antioxidant systems, is a cause and consequence of many vascular complains and serves as one of the biomarkers for these diseases. Furthermore, emerging evidence supports that OS and angiogenesis play vital roles in many dermatoses, such as psoriasis, atopic dermatitis, and skin tumor. This review summarizes recent findings on the role of OS as a trigger of angiogenesis in skin disorders, highlights newly identified mechanisms, and introduces the antiangiogenic and antioxidant therapeutic strategies.


Assuntos
Neovascularização Patológica/fisiopatologia , Dermatopatias/fisiopatologia , Humanos , Oxirredução , Estresse Oxidativo
12.
Pediatr Dermatol ; 36(4): e93-e94, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31042815

RESUMO

Up to 1.3 million children from the former Soviet Union (fSU) and Eastern Europe have been placed in institutional care worldwide. With the hope of ensuring the child's health in the immediate post-adoption period, these children are known to receive many injections of vaccines, vitamins, and medications, many unnecessary and often administered with unsafe technique. This practice can lead to formation of suppurative granulomas in these children. Though rare, dermatologists should be aware of these conditions in adoptees from Eastern Europe.


Assuntos
Abscesso/tratamento farmacológico , Abscesso/etiologia , Granuloma/etiologia , Dermatopatias/tratamento farmacológico , Dermatopatias/etiologia , Abscesso/fisiopatologia , Criança Adotada/estatística & dados numéricos , Claritromicina/uso terapêutico , Europa Oriental , Feminino , Granuloma/tratamento farmacológico , Granuloma/fisiopatologia , Humanos , Lactente , Injeções Intramusculares/efeitos adversos , Rifampina/uso terapêutico , Medição de Risco , Federação Russa , Dermatopatias/fisiopatologia , U.R.S.S.
13.
Skin Res Technol ; 25(5): 595-605, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31111588

RESUMO

BACKGROUND: The skin provides a permeable barrier which may be impaired in occupational settings. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH (SSpH) have been used in occupational settings to predict early onset of occupational skin diseases, to measure the effectiveness of prevention strategies for occupational skin diseases, and to assess skin condition during exposure. The aim was to compare the findings, identify shortcomings in the methodology and data reporting and furthermore, to make recommendations for future studies. MATERIALS AND METHODS: A literature study was conducted on studies published before December 2018 to provide a review on the measurement of TEWL, SCH and SSpH in occupational settings. RESULTS: TEWL, SCH and SSpH were previously measured in a wide variety of industries. Results between studies were highly variable, due to different study designs and different anatomical positions measured. Not all of the measurement conditions were reported and variations in study objectives led to data being reported and interpreted differently for most studies. CONCLUSION: Incomplete reporting of methodology hinders comparison of bioengineering measurements. No bioengineering method has been proven useful as a predictive tool for occupational skin diseases, however, it is useful in the acute assessment of skin condition. It is recommended that future studies on TEWL, SCH and SSpH adhere to guidelines for occupational settings as far as possible to enable comparison between studies.


Assuntos
Epiderme/fisiologia , Doenças Profissionais/fisiopatologia , Estado de Hidratação do Organismo/fisiologia , Dermatopatias/fisiopatologia , Perda Insensível de Água/fisiologia , Agricultura , Água Corporal/fisiologia , Humanos , Concentração de Íons de Hidrogênio , Indústrias , Enfermagem , Impressão , Fenômenos Fisiológicos da Pele
14.
Int J Low Extrem Wounds ; 18(2): 161-170, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31066321

RESUMO

Hiking has become very popular due to the physical and mental health benefits it provides. Skin lesions may occur with hiking and various factors contribute to their development. Although some lesions may appear to have little importance, something as simple as chaffing can cause serious ulcers in people with at-risk feet. Few studies have analyzed preexisting physical characteristics in hiking and addressed the development of lesions in hikers. This observational and longitudinal study examines the development of foot lesions during hiking, taking into account the influence of existing skin disorders, nail disorders, and/or toe deformities and other intrinsic factors of participants. The feet of 109 hikers doing a 29.6-km hike were analyzed, considering the intrinsic factors of participants and the possible influence of these factors in the development of foot lesions during the walk. The results show that some preexisting physical factors of participants such as gender, existing systemic disease, preexisting keratosis, dermatosis, nontraumatic and traumatic onychopathies, and toe deformities significantly predispose to the development of skin lesions. These factors also predispose to muscle lesions except for nontraumatic and traumatic onychopathies and toe deformities. Due to the influence of preexisting physical factors, such as preexisting keratosis, dermatosis, and toe deformities, in the development of foot lesions in hikers, it is worthwhile and advisable to check these factors before a hike to reduce the incidence of foot disorders. Ensuring adequate podiatry treatment a few days before the walk and warmup of muscles properly before starting are recommended.


Assuntos
Dermatoses do Pé/epidemiologia , Traumatismos do Pé/epidemiologia , Recreação , Lesões dos Tecidos Moles/epidemiologia , Caminhada , Adulto , Causalidade , Feminino , Seguimentos , Dermatoses do Pé/fisiopatologia , Doenças do Pé/epidemiologia , Doenças do Pé/fisiopatologia , Traumatismos do Pé/fisiopatologia , Humanos , Incidência , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Medição de Risco , Dermatopatias/epidemiologia , Dermatopatias/fisiopatologia , Lesões dos Tecidos Moles/fisiopatologia , Espanha
15.
Vet Dermatol ; 30(4): 307-e85, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31037780

RESUMO

BACKGROUND: Dermatological conditions are common in English bulldogs (EBs). HYPOTHESIS/OBJECTIVES: This cross-sectional study describes the dermatological health status of a group of EBs and compares the results with owner perceptions and its possible impact on quality of life (QoL). Computed tomographic (CT) findings of the ear canals were compared between EBs and mesaticephalic dogs. ANIMALS: Twenty-seven EBs participating in a health study in Finland. METHODS AND MATERIALS: A QoL questionnaire was completed for EBs with owner-reported clinical signs referable to the skin or ear. Clinical evaluation included recording the Canine Atopic Dermatitis Extent and Severity Index, the Otitis Index Score, false paw pad grading and the presence of interdigital furunculosis. These were summed to form a total clinical score (TCS). The cross-sectional surface areas of the horizontal ear canals were measured from CT images and compared with respective images of 14 mesaticephalic dogs collected from a patient database. RESULTS: All 27 EBs had abnormal findings on dermatological examination, but 37% of the owners had not recognized skin or ear signs. The median QoL score was 5.0 (range 0-12) and correlated with TCS (correlation coefficient = 0.507, P < 0.05). English bulldogs had narrower horizontal ear canals than mesaticephalic dogs (P < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: All EBs had abnormal dermatological findings that were unnoticed or considered to be of minor significance to the QoL by most owners. Narrow ear canals were common, possibly related to the brachycephalic conformation of the breed.


Assuntos
Doenças do Cão/fisiopatologia , Meato Acústico Externo/diagnóstico por imagem , Orelha/fisiopatologia , Dermatopatias/veterinária , Pele/fisiopatologia , Animais , Estudos Transversais , Cães , Orelha/anatomia & histologia , Feminino , Finlândia , Masculino , Animais de Estimação , Qualidade de Vida , Pele/patologia , Dermatopatias/fisiopatologia , Inquéritos e Questionários , Tomografia Computadorizada por Raios X
16.
Cutis ; 103(3): 153-156, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31039233

RESUMO

As interest in complementary and alternative medicine has grown, the relationship between diet and skin health has become an active area of research. Various supplements, plant derivatives, and antioxidants have gained attention as possible tools to prevent signs of aging and improve skin conditions. As such, knowledge of clinical trial data is important to counsel patients appropriately on risks and benefits of these complementary treatments and lifestyle modifications. Herein, we review the role of diet and supplements in preventing photoaging and treating common skin conditions.


Assuntos
Antioxidantes/uso terapêutico , Suplementos Nutricionais , Envelhecimento da Pele , Dermatopatias/dietoterapia , Dermatopatias/prevenção & controle , Vitaminas/uso terapêutico , Dieta , Humanos , Pele/efeitos dos fármacos , Pele/fisiopatologia , Dermatopatias/fisiopatologia
17.
Biotechnol J ; 14(7): e1900022, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30977574

RESUMO

The current status of skin tissue equivalents that have emerged as relevant tools in commercial and therapeutic product development applications is reviewed. Due to the rise of animal welfare concerns, numerous companies have designed skin model alternatives to assess the efficacy of pharmaceutical, skincare, and cosmetic products in an in vitro setting, decreasing the dependency on such methods. Skin models have also made an impact in determining the root causes of skin diseases. When designing a skin model, there are various chemical and physical considerations that need to be considered to produce a biomimetic design. This includes designing a structure that mimics the structural characteristics and mechanical strength needed for tribological property measurement and toxicological testing. Recently, various commercial products have made significant progress towards achieving a native skin alternative. Further research involve the development of a functional bilayered model that mimics the constituent properties of the native epidermis and dermis. In this article, the skin models are divided into three categories: in vitro epidermal skin equivalents, in vitro full-thickness skin equivalents, and clinical skin equivalents. A description of skin model characteristics, testing methods, applications, and potential improvements is presented.


Assuntos
Pele Artificial , Engenharia Tecidual , Humanos , Modelos Biológicos , Pele/citologia , Dermatopatias/fisiopatologia , Dermatopatias/cirurgia , Fenômenos Fisiológicos da Pele
18.
Adv Skin Wound Care ; 32(4): 176-182, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30845071

RESUMO

OBJECTIVE: To investigate the prevalence of medical adhesive-related skin injuries (MARSIs) and associated risk factors in a pediatric ICU (PICU). METHODS: A cross-sectional design was adopted in the PICU of a university-based children's hospital in eastern China. A total of 232 patients were enrolled, and 611 person-days were analyzed. MAIN OUTCOME MEASURES: Researchers assessed all patients daily for 2 weeks. The use of adhesives and prevalence of MARSIs were recorded. The patients' clinical data were also collected. The prevalence of MARSIs was calculated daily, and the risk factors were examined statistically. MAIN RESULTS: The MARSI prevalence ranged from 23.53% to 54.17% (mean, 37.15%). Multivariate analysis identified being female, age 2 years or younger, hospital stays longer than 5 days, infection, edema, and surgery as independent risk factors. Prevalence by product ranged from 19 to 53 per 1,000 product-days with a mean of 34 MARSIs per 1,000 product-days. The major MARSI types were epidermal stripping and skin tear. The face was the most common MARSI site, and tracheal intubation was the most common inciting condition. Implicated products were acrylate tapes with elastic cloth backings. CONCLUSIONS: Researchers concluded that MARSI is common in the PICU. Skin stripping and skin tear were the most common types, and the face was the most vulnerable site for MARSI, typically attributable to the cloth tape used to affix tracheal intubation. Careful attention should be paid to children with identified risk factors (females, age 2 years or younger, longer hospital stays, edema, infection, or surgery).


Assuntos
Unidades de Terapia Intensiva Pediátrica , Dermatopatias/etiologia , Pele/lesões , Adesivos Teciduais/efeitos adversos , Fatores Etários , Criança , Pré-Escolar , China , Cuidados Críticos/métodos , Estudos Transversais , Feminino , Hospitais Universitários , Humanos , Lactente , Recém-Nascido , Masculino , Determinação de Necessidades de Cuidados de Saúde , Prevalência , Medição de Risco , Dermatopatias/epidemiologia , Dermatopatias/fisiopatologia
19.
Biomed Pharmacother ; 113: 108775, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30889485

RESUMO

Autophagy, literally meaning "self-eating," is a highly conserved process that is part of the eukaryotic cell cycle. Morphologically, the double membrane contains vesicles with phagocytic components known as autophagosomes. Autophagy is often used as a cellular stress response and quality control mechanisms are used to maintain cell survival. Survival is facilitated by providing energy and metabolic precursors as well as removing damaged proteins or organelles. Moreover, autophagy refers to organelles fused together with part of the cell cytoplasm with a double or multi-membrane structure called phagosome. Research has demonstrated that autophagy is an important mediator of cell fate and has effects on inflammation, pathogen clearance, and antigen presentation. In recent years, studies discussing autophagy have increased in number. Nevertheless, only a small amount of research has considered the impact of autophagy on the pathogenesis of skin diseases. The skin is the largest organ of the body, with a surface area of around two square metre; it is the first line of defense against numerous environmental insults, including ultraviolet radiation, pathogens, mechanical stresses, and toxic chemicals. Autophagy is thought to be a vital modality for endogenous defenses against environmental derangements. This review provides an overview of autophagy machinery in keratinocytes, skin fibroblasts, melanocytes related to skin diseases as well as strategies for therapeutic modulation, for the future development of treatment for skin diseases.


Assuntos
Autofagia/fisiologia , Dermatopatias/fisiopatologia , Pele/metabolismo , Animais , Autofagossomos/metabolismo , Sobrevivência Celular/fisiologia , Fibroblastos/metabolismo , Humanos , Queratinócitos/metabolismo , Melanócitos/metabolismo , Pele/fisiopatologia , Dermatopatias/terapia
20.
Artigo em Inglês | MEDLINE | ID: mdl-30901070

RESUMO

Atrophoderma of Pasini and Pierini is a skin atrophy presenting as single or multiple sharply demarcated, hyperpigmented, non-indurated patches, with a slight depression of the skin, that can converge and form a confluent area with atrophy as a consequence. The condition was first described by Pasini in 1923 and subsequently by Pierini in 1936. They distinguished this form of atrophy from other diseases and conditions in which the atrophy is morphologically and clinically different. The disease was initially associated with Borrelia burgdorferi infection; however, at present, various theories have emerged for the appearance of the disease, linked to genetic, neurogenetic, and immunological factors. Here we present a patient that was admitted to the hospital due to disseminated lesions on the skin of the lower limbs, with slightly pigmented and atrophic skin along with irregular borders varying in size, from several mm to a few cm, clearly demarcated from the healthy skin, with no history of a tick bite or a family history of similar skin disorders.


Assuntos
Hiperpigmentação/patologia , Extremidade Inferior , Dermatopatias/patologia , Atrofia/patologia , Atrofia/fisiopatologia , Biópsia por Agulha , Humanos , Hiperpigmentação/fisiopatologia , Imuno-Histoquímica , Kosovo , Doença de Lyme/fisiopatologia , Masculino , Doenças Raras , Medição de Risco , Dermatopatias/fisiopatologia , Dermatopatias/terapia , Adulto Jovem
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