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1.
An Bras Dermatol ; 94(4): 462-469, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644623

RESUMO

Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient's face, conferring a leonine facies, or be part of life threatening diseases like scleromyxedema. This review will describe the most recent classification on lichen myxedematosus in the generalized (scleromyxedema) and the localized forms, as well as the different organ systems involved in scleromyxedema, diagnostic workup, current management, and prognosis.


Assuntos
Escleromixedema/diagnóstico , Escleromixedema/patologia , Dermatopatias/diagnóstico , Dermatopatias/patologia , Fibroblastos/patologia , Humanos , Mucinas , Escleromixedema/classificação , Escleromixedema/terapia , Pele/patologia , Dermatopatias/classificação , Dermatopatias/terapia
2.
An Bras Dermatol ; 94(4): 473-475, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644625

RESUMO

Atrophoderma of Pasini and Pierini is a skin disorder affecting dermal collagen and is clinically characterized by well-defined plaques of depressed skin. Histopathological changes are subtle, and in most cases, the diagnosis requires a comparative study with healthy skin from the same anatomical site. High frequency ultrasound is a useful imaging method for diagnosis of atrophic skin changes. A case is presented in which ultrasound can support the clinical and the histopathological diagnosis of atrophoderma of Pasini and Pierini.


Assuntos
Derme/diagnóstico por imagem , Derme/patologia , Dermatopatias/diagnóstico por imagem , Dermatopatias/patologia , Ultrassonografia Doppler em Cores/métodos , Adulto , Atrofia/diagnóstico por imagem , Atrofia/patologia , Biópsia , Diagnóstico Precoce , Feminino , Humanos
4.
J Craniofac Surg ; 30(7): e691, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31568160

RESUMO

A 15 month old boy was referred to our department after he and his mother moved to our country. He had been bitten by a brown recluse spider (Loxosceles reclusa) at the age of 7 months, in Brazil. Initially, he presented to the emergency department of his local hospital with rash in the scalp, near the bite. After a few days, he developed systemic disease with multiorgan failure and was admitted on intensive care unit, where he has been treated for 2 months. During this hospital stay he developed skin necrosis of the scalp, right preauricular, mandibular, and neck regions. He also developed right foot ischemia, which resulted in amputation. At the discharge time, he was under topical treatment with silver sulfadiazine, which was maintained until our observation, 8 months after being bitten. The child was successfully treated, and is now stable and awaiting lower limb prosthetic replacement.Loxoscelism (bites by spiders of the genus Loxosceles) is the only proven arachnological cause of dermonecrosis. The brown recluse spider, Loxosceles reclusa, is the best known and can cause necrotic dermatologic injury throw an enzyme, sphingomyelinase D, that has been shown to be cytotoxic to endothelial and red blood cells. Although the majority of persons bitten by a brown recluse spider probably will not seek medical attention, some patients may develop systemic loxoscelism, especially children.


Assuntos
Dermatopatias/patologia , Animais , Contagem de Eritrócitos , Eritrócitos , Humanos , Lactente , Insuficiência de Múltiplos Órgãos , Necrose , Couro Cabeludo , Picaduras de Aranhas , Aranhas
5.
J Drugs Dermatol ; 18(10): 1006-1010, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31584779

RESUMO

Pyogenic granuloma (PG) is an acquired vascular growth on the skin and mucous membranes. Even though PG is a benign tumor, treatment is required due to associated risk of ulceration and bleeding, cosmetic concerns, and the low likelihood of spontaneous regression. Treatment entails excisional surgery, cryotherapy, or electrocautery; recurrence however is a major problem. Beta-blockers became an attractive option for the treatment of vascular growths after it got approved for infantile hemangioma. PG was found to express beta adrenergic receptors, similarly to infantile hemangioma. Several publications have reported the use of oral and topical beta blockers such as timolol, propranolol, and betaxolol for the treatment of PG. In this study, we summarized the literature with regards to the effectiveness of topical beta blockers for the treatment of PG, and discussed all published case reports, case series, and open-label single arm trials. J Drugs Dermatol. 2019;18(10):1006-1010.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Granuloma Piogênico/tratamento farmacológico , Dermatopatias/tratamento farmacológico , Administração Cutânea , Administração Oral , Betaxolol/uso terapêutico , Ensaios Clínicos como Assunto , Granuloma Piogênico/patologia , Humanos , Propranolol/uso terapêutico , Receptores Adrenérgicos beta/metabolismo , Recidiva , Pele/patologia , Dermatopatias/patologia , Timolol/uso terapêutico , Resultado do Tratamento
6.
Adv Gerontol ; 32(3): 375-382, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31512424

RESUMO

The review article presents data on common dermatoses in elderly patients. At present, this topic is practically not discussed in the Russian geriatrics. The urgency of the problem is increasing due to the increase in life expectancy and the deterioration in the availability of specialized care (in particular, dermatological care), especially for elderly patients. The review discusses a number of clinical cases in elderly patients. This article is addressed to geriatrics, general practitioners, general practitioners (family doctors).


Assuntos
Dermatopatias , Geriatria/tendências , Humanos , Expectativa de Vida/tendências , Federação Russa , Dermatopatias/diagnóstico , Dermatopatias/patologia
7.
Life Sci ; 233: 116714, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31376370

RESUMO

Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. The present study utilizes an integrated cell culture model of keratinocytes and fibroblasts to mimic viable skin layers and investigate the possible effects of PM exposure after penetration through corneocytes. The skin perfection is upheld by homeostatic functionality of epidermal cells and the integrity of connective tissues. Exposure to xenobiotics could alter the skin cell homeostasis aggravating premature skin aging. Stimulation of HaCaT keratinocytes by PM collected from Beijing, China (CPM) increased the intracellular ROS levels triggering a cascade of events aggravating inflammatory responses and connective tissue degradation. In HDF fibroblasts, treatment with preconditioned keratinocyte culture media augmented inflammatory responses, cellular differentiation, and connective tissue degradation. Above events were marked by the increased intracellular ROS, inflammatory mediators, pro-inflammatory cytokines, matrix metalloproteinases (MMP)-1 and -2 levels, collagenase, and elastase activity. Fucosterol treatment of keratinocytes dose-dependently attenuated the detrimental effects both in keratinocytes and fibroblasts restoring the conditions near to physiological levels. Further evaluations could be advanced on developing fucosterol, in forms such as rejuvenating cosmeceuticals which could attenuate detrimental responses of CPM exposure.


Assuntos
Fibroblastos/efeitos dos fármacos , Inflamação/tratamento farmacológico , Queratinócitos/efeitos dos fármacos , Material Particulado/efeitos adversos , Dermatopatias/tratamento farmacológico , Pele/efeitos dos fármacos , Estigmasterol/análogos & derivados , Poluentes Atmosféricos/efeitos adversos , Células Cultivadas , Técnicas de Cocultura , Citocinas/metabolismo , Fibroblastos/metabolismo , Fibroblastos/patologia , Humanos , Inflamação/etiologia , Inflamação/metabolismo , Inflamação/patologia , Queratinócitos/metabolismo , Queratinócitos/patologia , NF-kappa B/metabolismo , Estresse Oxidativo , Espécies Reativas de Oxigênio/metabolismo , Pele/patologia , Dermatopatias/etiologia , Dermatopatias/metabolismo , Dermatopatias/patologia , Estigmasterol/farmacologia
8.
J Dermatol ; 46(10): 917-921, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31392741

RESUMO

While the etiology of sarcoidosis remains uncertain, mycobacteria have been suggested as a causative infectious agent. To investigate the causal relationship between mycobacteria and sarcoidosis, we performed a reverse blot hybridization assay (REBA) to identify mycobacteria from the skin samples of nine patients with sarcoidosis. Six of the nine samples were shown to be positive for mycobacteria by REBA, including Mycobacterium tuberculosis and non-tuberculous mycobacteria. This is the first study to identify mycobacteria from the skin samples of sarcoidosis patients using REBA, and our results could strengthen the etiologic association between mycobacteria and sarcoidosis.


Assuntos
Mycobacterium tuberculosis/isolamento & purificação , Micobactérias não Tuberculosas/isolamento & purificação , Sarcoidose/microbiologia , Dermatopatias/microbiologia , Pele/microbiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Sondas de DNA , DNA Bacteriano/isolamento & purificação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Técnicas de Sonda Molecular , Mycobacterium tuberculosis/genética , Micobactérias não Tuberculosas/genética , Reação em Cadeia da Polimerase , Sarcoidose/patologia , Pele/patologia , Dermatopatias/patologia
9.
An Bras Dermatol ; 94(3): 334-336, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31365664

RESUMO

Cutaneous mucinoses are a complex and diverse group of connective tissue disorders characterized by the accumulation of mucin and/or glycosaminoglycan in the skin and adnexa. Cutaneous focal mucinosis appears as a solitary, asymptomatic, skin-colored to white papule, nodule, or plaque located anywhere on the body or in the oral cavity. It presents mainly in adults and is characterized on histopathology by mucin throughout the upper and mid dermis. We describe the dermoscopy of two cases of cutaneous focal mucinosis. Both lesions presented a nonspecific homogenous whitish pattern; the first case also exhibited a sharply demarcated yellow border.


Assuntos
Mucinoses/patologia , Dermatopatias/patologia , Dermoscopia , Feminino , Glicosaminoglicanos , Humanos , Masculino , Pessoa de Meia-Idade , Mucinas
10.
Internist (Berl) ; 60(8): 775-782, 2019 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-31273399

RESUMO

Various specific skin alterations can occur in patients with malignant diseases. If these skin diseases occur as associated symptoms of a malignant process, they are called paraneoplastic. In this overview, obligate and frequent facultative paraneoplastic skin diseases are assigned according to the triggering type of malignancy. Some of the processes predominantly show a link with malignant diseases of the digestive tract, e.g. acanthosis nigricans, florid cutaneous papillomatosis, necrolytic migratory erythema, Leser-Trélat syndrome, palmoplantar keratoderma, panniculitis and pityriasis rubra pilaris. Others are predominantly associated with a hematolymphoid malignoma, e.g. acquired ichthyosis, exfoliative erythroderma, necrobiotic xanthogranuloma, paraneoplastic pemphigus, plane xanthoma, pyoderma gangrenosum, scleromyxedema, Sweet syndrome and leukocytoclastic vasculitis. In a third group paraneoplastic skin diseases are pooled in association with other malignancies, e.g. Trousseau's syndrome, dermatomyositis, erythema gyratum repens, hypertrichosis lanuginosa acquisita and papuloerythroderma of Ofuji. In order to initiate targeted diagnostics for detection of an underlying malignant disease, it is essential that accomplished physicians recognize the skin diseases that represent obligate or potential paraneoplasms as such.


Assuntos
Acantose Nigricans/patologia , Dermatomiosite/patologia , Síndromes Paraneoplásicas/patologia , Dermatopatias/patologia , Eritema/patologia , Humanos , Ictiose/patologia , Dermatopatias/etiologia
11.
Internist (Berl) ; 60(8): 783-791, 2019 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-31292667

RESUMO

Sclerosing skin manifestations are more a symptom than a diagnosis and must therefore be meticulously clarified. Systemic scleroderma as a multiorgan disease must be distinguished from localized scleroderma or morphea because in addition to a different clinical picture they have a different prognosis and necessitate other therapeutic procedures. Rare sclerosing skin diseases with implications for internal medicine are eosinophilic fasciitis, Buschke's scleredema adultorum, scleromyxedema and nephrogenic systemic fibrosis.


Assuntos
Eosinofilia/patologia , Fasciite/patologia , Dermopatia Fibrosante Nefrogênica/patologia , Escleredema do Adulto/patologia , Esclerodermia Localizada/patologia , Escleroderma Sistêmico/patologia , Escleromixedema/patologia , Dermatopatias/complicações , Humanos , Esclerose , Dermatopatias/patologia
12.
Pan Afr Med J ; 32: 198, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31312310

RESUMO

Pyoderma gangrenosum (PG) is a rare non-infectious neutrophilic dermatosis often unknowed. It usually presents with inflammatory skin ulcer, very painful, with rapid evolution. It is commonly found in a context of malignancy, inflammatory bowel disease, rheumatic and/or haematological disease. Its diagnosis is very often late after multiple therapeutic failures. We report a case of pyoderma gangrenosum whose diagnosis was not obvious. A patient was admitted to our department for a persistent dermatological lesion and adverse evolution despite debridements and the administration of antibiotics. He was followed for prostate cancer, high blood pressure and asthma. Due to observed biological abnormalities such as neutrophil leukocytosis with myelocyte and metamyelocyte myeloma, without blood blastosis and normochromic normocytic anemia, chronic myelogenous leukemia was suspected. It was later overturned by the various inconclusive supplementary examinations. This is how the diagnosis of PG was evoked and confirmed by anatomopathological examination showing a histopathological appearance of granulation tissue consistent with pyoderma gangrenosum and no sign of malignancy. The institution of a corticotherapy treatment resulted in the cure.


Assuntos
Corticosteroides/uso terapêutico , Pioderma Gangrenoso/diagnóstico , Dermatopatias/diagnóstico , Idoso , Humanos , Masculino , Pioderma Gangrenoso/tratamento farmacológico , Pioderma Gangrenoso/patologia , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia , Resultado do Tratamento
13.
Pan Afr Med J ; 32: 209, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31312321

RESUMO

Introduction: This study aims to determine the clinical and evolutionary profile of skin and soft tissue lesions in diabetics followed up at the dressing room. Methods: We conducted an observational descriptive and analytical study in the dressing room of the Marc Sankalé Diabetes Center, Dakar from 1 January to 31 December 2017. Our study focused on diabetics who were examined in the dressing room. Results: A total of 37.173 procedures were recorded at the Marc Sankalé Diabetes Center; 16.418 patients were treated in the dressing room, representing a prevalence of 14.16%. The average age of patients was 56,6 ±12 years, the sex ratio (M/F) was 0,88. Type 2 diabetes predominated (78,97%) and the average disease duration was 8.06 ± 7.9 years. The mean capillary blood glucose concentration was 2.4±1 g/l. Diabetic neuropathy was found in 72.33% of patients. Limb lesions were found in 93,98% of patients(1185 cases). The most common lesions included: ulcer (46,76%), abscess (13.46%), phlegmon (13.20%), gangrene (8.41%), erysipelas (3.78%), perforating ulcer (3.53%), intertrigo (3.95%). The lesions were be divided into infectious lesions (61,41), non-infectious lesions(33,50%), pure vascular lesions (1.57%) and mixed lesions (3.70%). Out of 1189 patients 7.57% had had osteitis. The germs found were Gram-positive bacteria (12.70%), Gram-negative bacteria (23.80%). Amputation was performed according to the topographical features of the lesion (p=0.00), the type of lesion (p=0.000), the seniority of diabetes (p=0.02), the type of diabetes (p=0.008), the presence of osteitis (p=0.006). Minor amputation was performed in 43,33% of cases, major amputation in 37.43% of cases; 70 deaths were recorded (5.89%). Conclusion: Skin and soft tissue lesions were dominated by diabetic foot. Mortality is not negligible and the risk of amputation was statistically related to the topographical features of the lesion, the type of lesion, the seniority and the type of diabetes and the presence of osteitis.


Assuntos
Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 2/complicações , Dermatopatias/epidemiologia , Infecções dos Tecidos Moles/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Amputação/estatística & dados numéricos , Glicemia/análise , Diabetes Mellitus Tipo 1/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Pé Diabético/epidemiologia , Neuropatias Diabéticas/epidemiologia , Feminino , Infecções por Bactérias Gram-Negativas/epidemiologia , Infecções por Bactérias Gram-Positivas/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Senegal/epidemiologia , Dermatopatias/patologia , Infecções dos Tecidos Moles/patologia , Adulto Jovem
14.
Artigo em Russo | MEDLINE | ID: mdl-31251857

RESUMO

The diseases of skin and subcutaneous tissue are an actual medical and social problem. The purpose of study was to analyze dynamics of incidence and prevalence of diseases of skin and subcutaneous tissue in population of the Republic of Bashkortostan in 2008-2017. The average rates of incidence and prevalence of these diseases in the Republic of Bashkortostan were significantly higher than relevant data in the Russian Federation and Volga federal district. In the Republic of Bashkortostan the study established increase in incidence rate of atopic dermatitis (primary morbidity increased up to 18.6%, total morbidity increased up to 20.2%) and psoriasis (total morbidity increased up to 3%). The low level of dispensary observation of patients with dermatitis in the medical organizations of the Republic of Bashkortostan was established. In 2017 full coverage with dispensary observation was established in case of children aged 0-14 years with discoid lupus erythematosus. The low level of dispensary observation of children with atopic dermatitis (42%) and adults with psoriasis (30.6%) was established. The study demonstrated necessity of further studying of total and primary morbidity of diseases of skin and subcutaneous tissue and also indices of dispensary observation of patients according nosologies and age groups, identification of corresponding risk factors, development and implementation of measures improving medical care at all stages of its rendering.


Assuntos
Dermatopatias , Tela Subcutânea , Adolescente , Adulto , Idoso , Bashkiria , Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido , Morbidade , Prevalência , Federação Russa , Dermatopatias/patologia , Tela Subcutânea/patologia
15.
Adv Exp Med Biol ; 1132: 89-98, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31037628

RESUMO

Skin is a large organ that is susceptible to damage by external forces, chronic inflammation, and autoimmune reactions. In general, tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. During this process, changes in the components that comprise the extracellular matrix are required to provide an environment that facilitates tissue remodeling. Among these extracellular matrix components, periostin (a glycoprotein secreted predominantly by dermal fibroblasts) has attracted much attention. In normal skin, periostin localizes mainly in the papillary dermis and basement membrane of the epidermis. However, it is expressed at higher levels in the dermis of lesional skin of those with atopic dermatitis, scars, systemic/limited scleroderma, melanoma, and cutaneous T cell lymphoma; expression is also increased by damage caused by allergic/autoimmune responses. Furthermore, periostin induces processes that result in development of dermal fibrosis; it also activates or protracts the immune response. The aim of this review is to summarize recent knowledge about the role of periostin in the pathogenesis of dermatoses.


Assuntos
Moléculas de Adesão Celular/fisiologia , Dermatopatias/patologia , Dermatite Atópica , Fibroblastos , Humanos , Melanoma , Pele
16.
Asian Pac J Cancer Prev ; 20(5): 1555-1561, 2019 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-31128062

RESUMO

Objective: The main objective of this study is to improve the classification performance of melanoma using deep learning based automatic skin lesion segmentation. It can be assist medical experts on early diagnosis of melanoma on dermoscopy images. Methods: First A Convolutional Neural Network (CNN) based U-net algorithm is used for segmentation process. Then extract color, texture and shape features from the segmented image using Local Binary Pattern ( LBP), Edge Histogram (EH), Histogram of Oriented Gradients (HOG) and Gabor method. Finally all the features extracted from these methods were fed into the Support Vector Machine (SVM), Random Forest (RF), K-Nearest Neighbor (KNN) and Naïve Bayes (NB) classifiers to diagnose the skin image which is either melanoma or benign lesions. Results: Experimental results show the effectiveness of the proposed method. The Dice co-efficiency value of 77.5% is achieved for image segmentation and SVM classifier produced 85.19% of accuracy. Conclusion: In deep learning environment, U-Net segmentation algorithm is found to be the best method for segmentation and it helps to improve the classification performance.


Assuntos
Melanoma/patologia , Dermatopatias/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Algoritmos , Teorema de Bayes , Análise por Conglomerados , Aprendizado Profundo , Dermoscopia/métodos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Máquina de Vetores de Suporte
17.
Malays J Pathol ; 41(1): 47-49, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31025637

RESUMO

Naevus sebaceus is a cutaneous hamartoma with the potential of developing into benign or malignant neoplasms. Syringocystadenoma papilliferum (SCAP) have been reported to originate from naevus sebaceus. SCAP is a rare, benign adnexal skin tumour of apocrine or eccrine type of differentiation which typically presents as a nodule or a plaque on the scalp or face. We report a case of syringocystadenoma papilliferum arising in an undiagnosed pre-existing naevus sebaceus in a 56-year-old female.


Assuntos
Hamartoma/patologia , Dermatopatias/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenomas Tubulares de Glândulas Sudoríparas/patologia , Comorbidade , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Gota/epidemiologia , Hamartoma/epidemiologia , Humanos , Hipertensão/epidemiologia , Pessoa de Meia-Idade , Dermatopatias/epidemiologia , Neoplasias das Glândulas Sudoríparas/epidemiologia , Adenomas Tubulares de Glândulas Sudoríparas/epidemiologia
18.
Radiat Oncol ; 14(1): 58, 2019 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-30961616

RESUMO

Doxycycline (DXC) is a tetracycline antibiotic which has been proposed as a breast cancer radiosensitizer by specifically reducing the expression of the DNA repair enzyme DNA PK in breast cancer initiating cells. Since DXC presents favorable pharmacokinetics properties including the capacity to cross the blood-brain barrier, it has been hypothesized that it could radiosensitize brain tumors as well. We have investigated the radiosensitizing capacity of DXC towards human glioma initiating cells (GIC)-driven orthotopic glioblastomas (GB) in NOD/SCID mice that faithfully mimic the growth properties of the clinical tumors of origin. DXC at 10 mg/Kg body weight was subcutaneously delivered daily, 5 days/week for 4 weeks. At the same time, radiotherapeutic fractions of 0.25 Gy to the head were delivered every 3-4 days (twice/week) for 15 weeks. No survival advantage was observed in DXC-treated mice as compared to vehicle-treated mice by this radiosensitizing protocol. On the contrary, skin damage with hair loss and deep ulcers were observed after 4 weeks in DXC-treated mice leading to discontinuation of drug treatment. These results do not support the use of DXC as a radiosensitizer for brain tumors and indicate skin damage as an important side effect of DXC.


Assuntos
Neoplasias Encefálicas/radioterapia , Doxiciclina/efeitos adversos , Glioblastoma/radioterapia , Células-Tronco Neoplásicas/efeitos da radiação , Radiossensibilizantes/efeitos adversos , Dermatopatias/etiologia , Animais , Antibacterianos/efeitos adversos , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/patologia , Raios gama , Glioblastoma/tratamento farmacológico , Glioblastoma/patologia , Camundongos , Camundongos Endogâmicos NOD , Camundongos SCID , Células-Tronco Neoplásicas/efeitos dos fármacos , Células-Tronco Neoplásicas/patologia , Dermatopatias/patologia
19.
BMJ Case Rep ; 12(4)2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-31015237

RESUMO

Malakoplakia (from the Greek malakos, 'soft' and plakos 'plaque') is a granulomatous inflammatory condition, commonly presenting as a plaque in the genitourinary system, but has been shown to affect a wide variety of structures including the skin. Presentation is varied and a high degree of clinical suspicion is needed to make a diagnosis. We report a case of cutaneous malakoplakia presenting as an inguinal swelling in a 48-year-old kidney transplant patient with temporally associated graft dysfunction. New groin swelling in an immunosuppressed patient often prompts investigation centred on a malignant cause. While this is often appropriate, less common infectious and inflammatory causes should be considered. This case highlights the importance of thorough workup and investigation, including histopathology, in immunosuppressed cohorts and acts as a reminder that less common and more complex diagnoses warrant consideration in this group.


Assuntos
Ceftriaxona/administração & dosagem , Virilha/patologia , Malacoplasia/patologia , Administração Intravenosa , Antibacterianos/uso terapêutico , Ceftriaxona/uso terapêutico , Constrição Patológica/patologia , Diagnóstico Diferencial , Edema/patologia , Virilha/diagnóstico por imagem , Humanos , Hospedeiro Imunocomprometido , Transplante de Rim/efeitos adversos , Malacoplasia/diagnóstico , Masculino , Pessoa de Meia-Idade , Doenças Raras , Pele/patologia , Dermatopatias/patologia , Resultado do Tratamento , Doenças Ureterais/complicações
20.
J Drugs Dermatol ; 18(4): 368-373, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31012566

RESUMO

Background: Local hyperthermia has been demonstrated to be a safe and efficacious treatment for warts. Objective: We aimed to evaluate the safety and efficacy of an epicutaneous heat patch to induce local hyperthermia for the treatment of warts. Methods: We performed an uncontrolled, proof of concept study by applying a novel, reproducible, epicutaneous heat patch to a target wart for 2 hours per day for 12 weeks. There were 15 evaluable participants. An untreated wart was also observed and measured. Wart measurements included the diameter in two dimensions, an investigator global assessment (IGA) score, wart clearance, and monitoring for adverse events as endpoints at week 12 (end of treatment) and week 24 (end of study). Results: No major adverse events were observed. 6.7% of participants reported minor cutaneous events. At week 24, 46.7% of participants achieved complete clearance of both warts. Limitations: The small sample size and lack of independent control in each participant were the main limiting factors. Conclusion: Local hyperthermia delivered by epicutaneous heat patches was well-tolerated, safe, and achieved complete clearance in both treated as well untreated warts in 46.7% of participants at week 24 after 12 weeks of daily use. Clinicaltrials.gov: NCT01746056 J Drugs Dermatol. 2019;18(4):368-373.


Assuntos
Temperatura Alta , Hipertermia Induzida , Dermatopatias/tratamento farmacológico , Verrugas/tratamento farmacológico , Administração Cutânea , Criança , Feminino , Dedos , Mãos , Humanos , Articulação do Joelho , Masculino , Dermatopatias/patologia , Dedos do Pé , Adesivo Transdérmico , Resultado do Tratamento , Verrugas/patologia
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