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2.
Int J Hyg Environ Health ; 222(3): 434-445, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30792121

RESUMO

Early detection of the health lesions induced by chronic arsenic exposure (HLICAE) are crucial to prevent permanent arsenic-induced damage. If HLICAE can be identified in time, appropriate preventive and therapeutic measures may be provided without various avoidable lesions. The present study aims to assess the probability of HLICAE early recognition with metabolomics. Applying a case-control study, 94 participants with HLICAE (cases) and other 94 subjects without HLICAE (controls) were matched with gender and age (±1 year), coming from a previous chronic arsenic exposure cohort. Serum metabolomic profiles were assessed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) and analyzed with univariate and multivariate statistics. A total of 210 and 364 features were detected in positive and negative ion modes (ESI+/ESI-), respectively. The altered metabolic pathways included lipid and amino acid metabolisms. 28 metabolomics-based biomarkers were significantly associated with HLICAE and provided areas under the curve (AUC, 95% confidence interval) of 0.898 (0.836, 0.960) and 0.908 (0.855, 0.960) in the discovery phase, 78.6% and 86.4% of positive predictive values in the validation phase, in distinguishing HLICAE from controls in ESI+/ESI-, respectively. This study provides novel insights on mechanisms of health effects probably induced by chronic arsenic exposure, and these biomarkers may be applied in HLICAE early detection.


Assuntos
Arsênico/toxicidade , Dermatopatias/induzido quimicamente , Dermatopatias/metabolismo , Adulto , Aminoácidos/metabolismo , China , Água Potável , Exposição Ambiental , Feminino , Humanos , Metabolismo dos Lipídeos , Masculino , Redes e Vias Metabólicas/efeitos dos fármacos , Metabolômica , Pessoa de Meia-Idade , Ensaios Clínicos Controlados Aleatórios como Assunto , Dermatopatias/sangue
3.
Medicine (Baltimore) ; 98(4): e14143, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30681578

RESUMO

Male-to-female transgender (MtF TG) individuals often report using illegal subcutaneous silicone injections for body feminisation. It leads to silicone dissemination and various dermatologic complications.We report the long-term complications of these feminisation procedures with blood smear examination and dermatologic examination.Between July 2015 and December 2015, 77 MtF TG consulting at Bichat Hospital (Paris, France) were included in this cross-sectional study. Blood smear examinations were performed by a trained haematologist to quantify the presence of silicone vacuoles in monocytes.All patients reported a history of massive amounts of silicone injections (mean 4 L, range 0.5-15 L). Most patients were South American (75/77, 97%). Fifty-nine (59/75, 79%) were HIV-seropositive, mostly with undetectable HIV RNA plasma levels (46/58, 80%). Clinical examinations reported dermatologic complications for all patients: lymphatic or subcutaneous migration of silicone (59%), inflammation (50%), varicose veins (39%), post-inflammatory pigmentation (20%), infection (14%) and abscesses (4%). Blood smear examination showed intracytoplasmic vacuoles containing silicone in monocytes in all patients.We did not chemically prove the silicone nature of the vacuoles. The design of this study does not allow evaluation of short-term complications that should not be minimized.Illicit massive silicone injections always induced chronic and definitive silicone blood diffusion with dermatologic complications. This study highlights the dangers and the inefficiency of clandestine esthetic surgery. There is a need for targeted information campaigns with transgender populations about silicone injections. Otherwise, these practices may persist.


Assuntos
Silicones/efeitos adversos , Dermatopatias/induzido quimicamente , Transexualismo , Adulto , Idoso , Comportamento Criminoso , Estudos Transversais , Difusão/efeitos dos fármacos , Feminino , Testes Hematológicos , Humanos , Injeções Subcutâneas/efeitos adversos , Masculino , Pessoa de Meia-Idade , Silicones/administração & dosagem , Dermatopatias/sangue , Dermatopatias/diagnóstico , Transexualismo/sangue , Adulto Jovem
4.
Cutan Ocul Toxicol ; 38(2): 118-124, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30501442

RESUMO

INTRODUCTION: Tiger dancing or Hulivesha, where the volunteers paint their bare body like a tiger and dance in a ritual during the Navarathri festival in Mangalore, India. There are no scientific studies done with the Hulivesha dancers at all, and therefore, we investigated the adverse effects of painting body like a tiger and dancing in the volunteers. OBJECTIVE/AIM: In this study, we investigated the clinico-haematological effects of topical application of lead-containing paint and dancing for three consecutive days in these dancers to ascertain the toxic effects of whole body painting and dancing. MATERIALS AND METHODS: This was a case-control study and was conducted during the Dasara festival in 2013 in the Huliveshadaris (study group) and the accompanying drummers (controls). Clinical, dermatological, and musculoskeletal examination were done before (day 0) and after the three days of the function (day 3). Blood was also collected and examined for alterations in the hematological parameters, lead, antioxidant glutathione, and lipid peroxidation levels. RESULTS: The results indicated that the all Hulivesha volunteers had severe musculoskeletal pain, while few also complained of skin reactions (61.6%), headache (25%) and nausea, and vomiting (18.75%). The results also indicated that topical application increased the levels of blood lead, caused a change in the haematological profile, decreased glutathione and increased lipid peroxidation (p < 0.03-0.0001). CONCLUSIONS: The results from this study clearly shows that topical application of the acrylic paint increases lead, changes haematological parameters and imparts adverse skin reactions.


Assuntos
Chumbo/toxicidade , Pintura/toxicidade , Administração Tópica , Adolescente , Estudos de Casos e Controles , Dança , Glutationa/sangue , Cefaleia/induzido quimicamente , Férias e Feriados , Humanos , Índia/epidemiologia , Chumbo/sangue , Peroxidação de Lipídeos , Masculino , Dor Musculoesquelética/induzido quimicamente , Náusea/induzido quimicamente , Dermatopatias/sangue , Dermatopatias/induzido quimicamente , Vômito/induzido quimicamente
7.
Ann Agric Environ Med ; 25(3): 421-427, 2018 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-30260197

RESUMO

INTRODUCTION AND OBJECTIVE: Polychlorinated biphenyls (PCBs) have been used commercially since 1929 as dielectric and insulating non-flammable substances, additives for paints, etc. In Slovakia, 60 chemical production workers highly exposed to PCBs (mainly to Delor 103) were studied with duration of exposure ranging from 3 months to 19 years. MATERIAL AND METHODS: Clinical examinations of skin, skin histology and laboratory tests concerning lipid metabolism, iron metabolism and levels of copper provided comparisons with a control group of healthy individuals and/or the upper limits of normal values. RESULTS: Skin changes were found in 47 % of individuals. In most cases, milia-like efflorescences (57.14 %) occurred, as well as comedones (55.35 %); other symptoms occurred in a smaller number of workers. Hyperkeratosis, acanthosis of the epidermis (particularly in hair follicles), and a cellular infiltration of the corium were all found through histology. The intensity of cutaneous affections was associated with the changes in laboratory tests. Elevated triglycerides, cholesterol, and phospholipids were found in exposed workers. After a further two years, a significant increase in triglycerides was found in exposed individuals when compared with the control group. In addition, a significant increase in serum levels of copper, and total and unsaturated iron-binding capacity was detected. CONCLUSIONS: Anamnesis showed that some people directly exposed to PCBs may develop skin changes after three months of occupational exposure. The results represent a unique snapshot of worker exposure at a given location, representing the basis for comparison with the population who grew up in the area and still live there today.


Assuntos
Doenças Profissionais/etiologia , Exposição Ocupacional/efeitos adversos , Bifenilos Policlorados/toxicidade , Dermatopatias/etiologia , Adulto , Colesterol/sangue , Cobre/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/sangue , Doenças Profissionais/epidemiologia , Doenças Profissionais/patologia , Estudos Retrospectivos , Dermatopatias/sangue , Dermatopatias/epidemiologia , Dermatopatias/patologia , Eslováquia/epidemiologia , Triglicerídeos/sangue , Adulto Jovem
9.
Vet Parasitol ; 255: 20-25, 2018 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-29773131

RESUMO

Habronemosis is a common parasitic disease of horses worldwide. In order to investigate how haptoglobin (Hp), serum amyloid A (SAA), oxidative stress markers, nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor (TNF- α), varies in cutaneous habronemosis, 30 horses with the clinical disease and 20 clinically healthy horses were included in the current study. The serum levels of Hp, SAA, and proinflammatory cytokines (IL-6 and TNF-α), NO, malondialdehyde (MDA), super oxide dismutase (SOD), glutathione (GSH), and total antioxidant capacity (TAC) were determined in horses before and after two weeks of treatment. The serum levels of Hp, SAA, IL-6, TNF-α and MDA were significantly elevated in infected horses as compared to the controls. Alternately, the serum levels of SOD, GSH, TAC and NO, were recorded low in infected horses as compared to the controls. All tested markers resumed the same levels after treatment as in control group. The Hp, SAA, IL-6, TNF-α, and MDA exhibited a high degree of clinical accuracy of the cases diagnosis. The area under the curve (AUC) for acute phase proteins (SAA, Hp), IL-6, TNF-α, and MDA was 0.87, 0.94, 0.96, 0.96 and 1.0, respectively. These findings showed that Hp, SAA, IL-6, TNF-α, and MDA may be supportive in the diagnosis of cutaneous habronemosis in horses and, simultaneously, they can also be used to monitor the progress of the treatment.


Assuntos
Proteínas da Fase Aguda/metabolismo , Citocinas/sangue , Doenças dos Cavalos/diagnóstico , Óxido Nítrico/sangue , Dermatopatias/veterinária , Infecções por Spirurida/veterinária , Spiruroidea/fisiologia , Animais , Biomarcadores/sangue , Doenças dos Cavalos/sangue , Doenças dos Cavalos/parasitologia , Cavalos , Estresse Oxidativo , Dermatopatias/sangue , Dermatopatias/diagnóstico , Dermatopatias/parasitologia , Infecções por Spirurida/sangue , Infecções por Spirurida/diagnóstico , Infecções por Spirurida/parasitologia
10.
J Dermatol ; 45(8): 943-950, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29782055

RESUMO

Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn® is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leukocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leukocytes. Reports on the clinical efficacy of GMA in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to GMA, include pyoderma gangrenosum, skin lesions of Behçet's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult-onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes. In association with clinical studies, efforts to understand the mechanisms of GMA have made significant progress. GMA selectively depletes elevated myeloid lineage leukocytes through binding between blood immunoglobulin G or complement iC3b, which form on the surface of CA beads and the Fcγ receptors or complement receptors expressed on the myeloid lineage cells. However, GMA has immunomodulatory effects including down-modulation of inflammatory cytokine profile, changes in leukocyte surface receptors and induction of regulatory T cells. These actions render GMA a unique non-pharmacological treatment option for patients with chronic dermatoid conditions, which are difficult to treat with pharmacological preparations.


Assuntos
Granulócitos/imunologia , Doenças do Sistema Imunitário/terapia , Leucaférese/métodos , Monócitos/imunologia , Dermatopatias/terapia , Adsorção , Humanos , Doenças do Sistema Imunitário/sangue , Doenças do Sistema Imunitário/imunologia , Dermatopatias/sangue , Dermatopatias/imunologia , Resultado do Tratamento
12.
Sci Rep ; 8(1): 6067, 2018 04 17.
Artigo em Inglês | MEDLINE | ID: mdl-29666436

RESUMO

In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans, the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic bats tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here we report blood profiles, along with body mass index (BMI), infection intensity and hibernation temperature, in greater mouse-eared bats (Myotis myotis). We sampled three European hibernacula that differ in geomorphology and microclimatic conditions. Skin lesion counts differed between contralateral wings of a bat, suggesting variable exposure to the fungus. Analysis of blood parameters suggests a threshold of ca. 300 skin lesions on both wings, combined with poor hibernation conditions, may distinguish healthy bats from those with homeostatic disruption. Physiological effects manifested as mild metabolic acidosis, decreased glucose and peripheral blood eosinophilia which were strongly locality-dependent. Hibernating bats displaying blood homeostasis disruption had 2 °C lower body surface temperatures. A shallow BMI loss slope with increasing pathogen load suggested a high degree of infection tolerance. European greater mouse-eared bats generally survive P. destructans invasion, despite some health deterioration at higher infection intensities (dependant on hibernation conditions). Conservation measures should minimise additional stressors to conserve constrained body reserves of bats during hibernation.


Assuntos
Ascomicetos/fisiologia , Quirópteros/microbiologia , Hibernação , Interações Hospedeiro-Patógeno , Micoses/veterinária , Dermatopatias/veterinária , Animais , Índice de Massa Corporal , Quirópteros/sangue , Quirópteros/fisiologia , Micoses/sangue , Micoses/microbiologia , Micoses/patologia , Dermatopatias/sangue , Dermatopatias/microbiologia , Dermatopatias/patologia
14.
Allergol Int ; 67(4): 487-495, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29598931

RESUMO

BACKGROUND: Sarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4+ T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown. The objective of this study is to elucidate the role of TARC in sarcoidosis by investigating its expression in peripheral blood and at inflammatory sites. We also examined its relationship with clinical features. METHODS: Serum levels of TARC, soluble interleukin 2 receptor, angiotensin-converting enzyme, and lysozyme were measured in 82 sarcoidosis patients. The Th1 and Th2 balance in circulating CD4+ T cells was evaluated by flow cytometry. The immunohistochemical staining of TARC and CCR4 was performed in order to identify the source of TARC in affected skin tissues. RESULTS: TARC serum levels were elevated in 78% of patients and correlated with disease severity. The percentage of CCR4+ cells and the CCR4+/CXCR3+ cell ratios were significantly higher in sarcoidosis patients than in normal subjects (P = 0.002 and P = 0.015, respectively). Moreover, TARC was expressed by monocyte/macrophage lineage cells within granulomas. The abundancy as well as distribution of TARC staining correlated with its serum levels. CONCLUSIONS: The present results suggest that elevations in TARC drive an imbalanced Th2- weighted immune reaction and might facilitate prolonged inflammatory reactions in sarcoidosis.


Assuntos
Quimiocina CCL17/sangue , Granuloma/sangue , Sarcoidose/sangue , Dermatopatias/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Quimiocina CCL17/imunologia , Progressão da Doença , Feminino , Granuloma/imunologia , Humanos , Macrófagos/imunologia , Masculino , Pessoa de Meia-Idade , Monócitos/imunologia , Receptores CCR4/imunologia , Receptores CXCR3/imunologia , Sarcoidose/imunologia , Pele/imunologia , Dermatopatias/imunologia , Células Th2/imunologia
15.
Acta Derm Venereol ; 98(5): 506-511, 2018 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-29437186

RESUMO

Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG4+ plasma cells has led to discussion about the relationship between systemic plasmacytosis and IgG4-related disease. This study examined IgG4+/IgG+ plasma cell ratios in 4 patients with systemic plasmacytosis and 12 patients with other skin diseases that show marked infiltration of plasma cells. Furthermore, we examined whether these cases met one of the pathological diagnostic criteria for IgG4-related disease (i.e. IgG4+/IgG plasma cells ratio of over 40%). Only one out of 4 patients with systemic plasmacytosis met the criterion. These results suggest that systemic plasmacytosis and IgG4-related disease are distinct diseases.


Assuntos
Doenças Autoimunes/imunologia , Imunoglobulina G/análise , Plasmócitos/imunologia , Dermatopatias/imunologia , Pele/imunologia , Adulto , Idoso , Doenças Autoimunes/sangue , Doenças Autoimunes/diagnóstico , Biomarcadores/análise , Biomarcadores/sangue , Biópsia , Feminino , Humanos , Imunoglobulina G/sangue , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Plasmócitos/patologia , Valor Preditivo dos Testes , Pele/patologia , Dermatopatias/sangue , Dermatopatias/diagnóstico
16.
Pediatr Diabetes ; 19(4): 733-740, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29484783

RESUMO

BACKGROUND: Dermatological complications in children and adolescents that are related to continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) have not been well-characterized. This study examined the prevalence and characteristics of different types of dermatological complications. METHODS: Online questionnaires regarding dermatological complications related to CSII and/or CGM were returned from a total of 144 children and adolescents, aged 2 to 20 years. Both previous and current skin problems were reported along with their clinical characteristics. Descriptive statistics, χ2 tests, and multivariate analyses were used to evaluate the data. RESULTS: Of 143 patients using CSII, 90% had previous and 63% reported current dermatological complications. Non-specific eczema was most frequently reported and was currently present in 25.7% of the patients. These results were independent of age and current CGM use. Among the 76 patients using CGM, 46% reported current dermatological complications. A history of atopy was associated with dermatological complications in individuals using CSII, but not CGM. The patients rated CGM-related dermal issues as significantly worse than those associated with CSII (P < .05). CONCLUSIONS: Dermatological complications can be a serious problem in treating pediatric and adolescent patients of all ages with CSII and/or CGM. Only a few clinical characteristics associated with these complications were identified in this study, highlighting the need for prospective studies that might lead to improvements in the prevention and treatment of dermatological problems.


Assuntos
Glicemia/metabolismo , Diabetes Mellitus Tipo 1 , Sistemas de Infusão de Insulina , Insulina/administração & dosagem , Dermatopatias/epidemiologia , Adolescente , Técnicas Biossensoriais/instrumentação , Técnicas Biossensoriais/estatística & dados numéricos , Glicemia/efeitos dos fármacos , Automonitorização da Glicemia/efeitos adversos , Automonitorização da Glicemia/instrumentação , Criança , Estudos Transversais , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/tratamento farmacológico , Diabetes Mellitus Tipo 1/epidemiologia , Feminino , Humanos , Insulina/efeitos adversos , Sistemas de Infusão de Insulina/efeitos adversos , Sistemas de Infusão de Insulina/estatística & dados numéricos , Masculino , Prevalência , Dermatopatias/sangue , Dermatopatias/classificação , Dermatopatias/complicações
17.
Indian J Dermatol Venereol Leprol ; 84(2): 148-152, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29376509

RESUMO

Background: Immunoglobulin E (IgE) plays an important role in allergic diseases. Although several studies have shown the association of serum total IgE and allergen-specific IgE levels with allergic dermatological diseases such as atopic dermatitis, there are few studies addressing this association for skin diseases in general. Aims: We sought to evaluate IgE levels in skin diseases and investigate the differences based on the disease type and clinical factors such as gender and age. Methods: Data from 2836 patients who visited the dermatologic clinic of the Konkuk University Hospital, Seoul, Republic of Korea for 4 years were reviewed to document IgE levels and clinical information. IgE levels were collated with the type of skin disease, gender, and age. Results: Patients with atopic dermatitis had a much higher total IgE level and were more susceptible to allergens as compared to other disease groups. Patients in other disease groups showed no significant differences in IgE levels. Men showed higher total IgE levels but the gender differences decreased with increasing age. Limitations: The data were collected from patients at a referral centre and thus may not represent the general population of dermatologic patients. There was a lack of information regarding factors that could potentially influence IgE levels such as smoking history and disease severity. Conclusions: The results suggest that there are physiological or environmental differences in IgE-mediated immune responses between males and females. Also, except for atopic dermatitis, there were no clinical differences in the IgE levels among various skin diseases.


Assuntos
Alérgenos/sangue , Imunoglobulina E/sangue , Dermatopatias/sangue , Dermatopatias/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
18.
J Cosmet Dermatol ; 17(3): 511-517, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28940857

RESUMO

BACKGROUND: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers. OBJECTIVES: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. METHODS: This was a cross-sectional retrospective study including 186 women with PCOS and 113 age-matched without PCOS women. Acne grade, hirsutism, seborrhea, AGA, and AN were recorded. Hormonal and metabolic parameters were measured. RESULTS: The most common finding was acne, and AN was the least dermatological manifestations between PCOS and non-PCOS groups. The severity location and type of acne did not differ in PCOS women compared to non-PCOS women. Significant differences were found with respect to free androgen index (FAI) (P = .036), sex hormone-binding globulin (SHBG) (P = .023), and body mass index (BMI) (P = .001) between PCOS with acne and PCOS without acne groups. Overall, age (P = .005) was significantly decreased, while BMI (P = .004) was significantly higher in PCOS with hirsutism. The mean serum total testosterone (TT), dehydroepiandrosterone sulfate, and FAI were significantly elevated, but SHBG was decreased between PCOS with and without hirsutism groups. There were significantly different BMI (P = .018) and triglyceride (P = .024) except other hormonal parameter of without AGA group. CONCLUSION: This study indicated a strong correlation between hirsutism and metabolic abnormalities. Hirsutism is the most common cutaneous finding in PCOS women. Acne and AGA are associated with other manifestations of clinical hyperandrogenism, but not obvious markers of biochemical hyperandrogenemia and metabolic dysfunction.


Assuntos
Androgênios/sangue , Síndrome do Ovário Policístico/sangue , Globulina de Ligação a Hormônio Sexual/metabolismo , Dermatopatias/sangue , Dermatopatias/epidemiologia , Acantose Nigricans/sangue , Acantose Nigricans/epidemiologia , Acne Vulgar/sangue , Acne Vulgar/epidemiologia , Adulto , Fatores Etários , Alopecia/sangue , Alopecia/epidemiologia , Biomarcadores/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , China/epidemiologia , Estudos Transversais , Dermatite Seborreica/sangue , Dermatite Seborreica/epidemiologia , Feminino , Hirsutismo/sangue , Hirsutismo/epidemiologia , Humanos , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Índice de Gravidade de Doença , Triglicerídeos/sangue , Adulto Jovem
19.
Am J Clin Dermatol ; 19(2): 223-235, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28994020

RESUMO

Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this category of patients at risk for vitamin D deficiency. Maintaining a vitamin D serum concentration within normal levels is warranted in atopic dermatitis, psoriasis, vitiligo, polymorphous light eruption, mycosis fungoides, alopecia areata, systemic lupus erythematosus, and melanoma patients. The potential determinants of vitamin D status, as well as the benefits and risks of vitamin D (with a special focus on the skin), will be discussed in this article.


Assuntos
Suplementos Nutricionais , Dermatopatias/tratamento farmacológico , Deficiência de Vitamina D/prevenção & controle , Vitamina D/uso terapêutico , Vitaminas/uso terapêutico , Humanos , Fatores de Risco , Pele/imunologia , Pele/metabolismo , Pele/efeitos da radiação , Dermatopatias/sangue , Dermatopatias/complicações , Dermatopatias/imunologia , Pigmentação da Pele/imunologia , Pigmentação da Pele/efeitos da radiação , Luz Solar/efeitos adversos , Vitamina D/sangue , Vitamina D/imunologia , Vitamina D/metabolismo , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/etiologia , Vitaminas/sangue , Vitaminas/imunologia , Vitaminas/metabolismo
20.
Exp Dermatol ; 27(8): 815-823, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29151267

RESUMO

The incidence of type 2 diabetes mellitus (DM) has been increasing rapidly, and the disease has become a serious sociomedical problem. Many skin problems, such as xerosis, pruritus, skin infections and delayed wound healing, that might be related to chronic impairment of skin barrier function decrease the quality of life in patients with DM. However, the status of the permeability and antimicrobial barrier of the skin in DM remains unknown. This study aimed to elucidate skin barrier impairment in patients with type 2 DM and its pathomechanisms using classic animal models of type 2 DM. Functional studies of the skin barrier and an analysis of stratum corneum (SC) lipids were compared between patients with type 2 DM and age- and sex-matched non-diabetes controls. Also, functional studies on the skin barrier, epidermal lipid analyses, and electron microscopy and biomolecular studies were performed using type 2 DM animal models, db/db and ob/ob mice. Patients with type 2 DM presented with epidermal barrier impairments, including SC hydration, which was influenced by blood glucose control (HbA1c level). In the lipid analysis of SC, ceramides, fatty acids and cholesterol were significantly decreased in patients with type 2 DM compared with controls. Type 2 DM murine models presented with severe hyperglycaemia, impairment of skin barrier homeostasis, decreases in epidermal proliferation and epidermal lipid synthesis, decreases in lamellar body (LB) and epidermal antimicrobial peptides (AMPs), an increase in receptors for advanced glycation end-product (AGE) in the epidermis and an increase in serum AGE. Impairment of the skin barrier was observed in type 2 DM, which results in part from a decrease in epidermal proliferation. Serum AGE and its epidermal receptors were increased in type 2 diabetic mice which display impaired skin barrier parameters such as epidermal lipid synthesis, LB production, epidermal AMP and SC lipids.


Assuntos
Peptídeos Catiônicos Antimicrobianos/sangue , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/imunologia , Produtos Finais de Glicação Avançada/sangue , Dermatopatias/imunologia , Idoso , Animais , Estudos de Casos e Controles , Proliferação de Células , Diabetes Mellitus Tipo 2/complicações , Ácidos Graxos/metabolismo , Feminino , Homeostase , Humanos , Hiperglicemia/metabolismo , Lipídeos/química , Masculino , Camundongos , Camundongos Transgênicos , Pessoa de Meia-Idade , Permeabilidade , Qualidade de Vida , Pele/metabolismo , Dermatopatias/sangue , Dermatopatias/complicações
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