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1.
BMJ Open ; 13(1): e068893, 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36657764

RESUMO

INTRODUCTION: Ichthyoses comprise a heterogenous group of rare genetic skin disorders that involves the entire skin surface, often with additional syndromic features, and pose many clinical challenges. Without curative intervention, the mainstay of life-long symptom management is supportive in nature and can remain the responsibility of the caregiver. Although impact on the wider family is considered an important outcome of policies and services, there is a lack of caregiver consensus on what outcome domains to measure to fully assess the impact of ichthyosis on the patient and the caregiver. This project aims to identify a set of core outcome domains towards a core outcome set for ichthyosis that can measure all relevant concepts of ichthyosis in clinical practice, service delivery and research. METHODS AND ANALYSIS: Following the COMET (Core Outcome Measures in Effectiveness Trials) initiative, this project will employ a mixed-method study design which was developed using public and patient involvement and an international multidisciplinary expert group (clinical experts, patients and their representatives, policymakers, researchers and service providers). Experts by experience, or caregivers, will be recruited through online ichthyosis support groups. Phase one will focus on item generation and involve: (1) a systematic literature review, (2) a multimethods international qualitative study with ichthyosis caregivers and (3) co-development of items for an e-survey. Phase two, item refinement, will employ a novel four-pronged consensus approach: (1) an e-Delphi survey, (2) statistical analysis of e-Delphi survey results, (3) online qualitative feedback and (4) an online consensus discussion. All methodological considerations will be clearly linked with each Core Outcome Set-STAndards for Developing recommendation. ETHICS AND DISSEMINATION: Research Ethics Committee approval obtained from the School of Psychology, Ulster University (UK)(Ref:REC/20/0004). Results will be presented in published international peer-reviewed journals, at scientific meetings and support groups. REGISTRATION: COMET database (January 2019).


Assuntos
Ictiose , Dermatopatias , Humanos , Cuidadores , Técnica Delfos , Projetos de Pesquisa , Dermatopatias/terapia , Ictiose/terapia , Medidas de Resultados Relatados pelo Paciente , Resultado do Tratamento , Revisões Sistemáticas como Assunto
2.
J Drugs Dermatol ; 22(1): 101-104, 2023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-36607754

RESUMO

BACKGROUND: Studies suggest potential heterogeneity in telemedicine adoption with potential to exacerbate healthcare access inequity. METHODS: A pre-validated survey was electronically sent to a proprietary listserv of practicing US-based dermatologists. Results were stratified by when teledermatology was adopted. Chi-square and odds ratios (OR) with 95% confidence intervals (95%CI) were used to analyze categorical data while single-factor ANOVA with posthoc Tukey-Kramer was used for continuous data. RESULTS: 338 practicing US-based dermatologists completed the questionnaire. Academic/Government dermatologists were 4-times more likely (OR 4.08, 95%CI 2.37-7.03) to adopt teledermatology pre-COVID than private-practice dermatologists. Dermatologists with ≤10 years of experience were 1.8-times (OR 1.8, 95%CI 1.01-3.18) and 2.82-times more likely (OR 2.82, 95%CI 0.78-10.25) to adopt teledermatology pre-COVID-19 or at all, respectively, compared to dermatologists with ≥20 years of experience. Teledermatology adopters practiced more medical-dermatology (P<.0001) than non-adopters, who reported practicing more dermatologic surgery (P=.003; Tukey-Kramer α<.05) and dermatopathology (P<.0001; Tukey-Kramer α<.05). Pre-COVID-19 adopters were 4-times more likely (OR 4.69, 95%CI 1.46-15.07) to switch/incorporate live-interactive-only teledermatology (LI) post-COVID-19. Post-COVID-19 adopters were 6-times more likely (OR 6.09, 95%CI 3.36-11.06) to utilize LI than Pre-COVID-19 adopters. Pre-COVID-19 adopters use teledermatology for a larger proportion of patient visits than Post-COVID-19 adopters (19.6% v 10.4%, P<.0001), but also are 3.43-times more likely (OR 3.43, 95%CI 1.82-6.46) to report future decreases in usage. LIMITATIONS: Cross-sectional retrospective survey and potential response bias. CONCLUSION: Current teledermatology usage may be a suitable tool for medical-dermatology-focused practices. Material hurdles still exist for procedurally-oriented practices and future studies should investigate these barriers to maximize equitable access to dermatological care. J Drugs Dermatol. 2023;21(1):101-104. doi:10.36849/JDD.7169.


Assuntos
COVID-19 , Dermatologia , Dermatopatias , Humanos , Estados Unidos/epidemiologia , Dermatologia/métodos , Estudos Transversais , Estudos Retrospectivos , COVID-19/diagnóstico , COVID-19/epidemiologia , Acesso aos Serviços de Saúde , Dermatopatias/diagnóstico , Dermatopatias/epidemiologia , Dermatopatias/terapia
3.
Int J Mol Sci ; 24(2)2023 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-36675037

RESUMO

Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and homeostasis by modulating how the immune system is activated. Several studies have documented the critical role of Tregs in suppressing the functions of effector T cells and antigen-presenting cells. Under certain conditions, Tregs can lose their suppressive capability, leading to a compromised immune system. For example, mutations in the Treg transcription factor, Forkhead box P3 (FOXP3), can drive the development of autoimmune diseases in multiple organs within the body. Furthermore, mutations leading to a reduction in the numbers of Tregs or a change in their function facilitate autoimmunity, whereas an overabundance can inhibit anti-tumor and anti-pathogen immunity. This review discusses the characteristics of Tregs and their mechanism of action in select autoimmune skin diseases, transplantation, and skin cancer. We also examine the potential of Tregs-based cellular therapies in autoimmunity.


Assuntos
Doenças Autoimunes , Dermatopatias , Neoplasias Cutâneas , Humanos , Linfócitos T Reguladores , Doenças Autoimunes/etiologia , Doenças Autoimunes/terapia , Autoimunidade , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/terapia , Dermatopatias/etiologia , Dermatopatias/terapia , Fatores de Transcrição Forkhead
4.
Pediatr Ann ; 52(1): e23-e30, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36625801

RESUMO

Skin lesions of the face, trunk, and extremities are commonly seen in the pediatric population. Although most of these lesions are benign, they can be locally destructive or interfere with normal development. Recognition and diagnosis of these lesions allow for timely workup and referral; treatment, if needed; and facilitation of parental discussions. The purpose of this article is to review common pediatric skin and soft-tissue lesions-or "lumps, bumps, and birthmarks"-to assist with diagnosis, workup, and guidelines for referral to pediatric plastic surgery. [Pediatr Ann. 2023;52(1):e23-e30.].


Assuntos
Dermatopatias , Criança , Humanos , Dermatopatias/diagnóstico , Dermatopatias/terapia , Pele , Diagnóstico Diferencial
5.
Front Immunol ; 13: 1033498, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36466901

RESUMO

Objective: To investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis. Methods: A BALB/c mouse psoriasis model induced by imiquimod was established and randomly divided into the control group, model group, indirubin group, hUC-MSCs group, and indirubin combined with hUC-MSCs group. Psoriasis area and severity index (PASI) score was used to observe skin lesion changes in the psoriasis-like mouse model. The epidermal scale, the degree of keratinization, and the infiltration of inflammatory cells were observed by hematoxylin eosin (HE) staining. The concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice were measured using enzyme-linked immunosorbent assay (ELISA). Results: The PASI integral trend chart indicates that hUC-MSCs and indirubin and the combination of drugs could relieve the appearance of skin lesions and accelerate the recovery of skin lesions. The indirubin group had the best effect in improving the scale of skin lesions. HE staining showed that the number of parakeratosis cells in the three treatment groups was significantly reduced, the degree of erythrocyte extravasation dermis hyperplasia and inflammatory cell infiltration was significantly lower than that in the model group, and the skin thickness and spleen index of the combined treatment group exhibited the most noticeable improvement. ELISA showed that the concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice in the hUC-MSCs treatment group, indirubin group, and combined administration group were all decreased compared with those in the model group, and the concentrations of IFN-γ, IL-17A, and IL-23 could be decreased significantly in the indirubin group. Conclusions: Both hUC-MSCs and indirubin can effectively reduce psoriasis-like lesions in BALB/c mice, and the combined administration of these drugs has the best effect.


Assuntos
Células-Tronco Mesenquimais , Psoríase , Dermatopatias , Humanos , Camundongos , Animais , Interleucina-17 , Camundongos Endogâmicos BALB C , Fator de Necrose Tumoral alfa , Cordão Umbilical , Psoríase/terapia , Dermatopatias/terapia , Amarelo de Eosina-(YS) , Interleucina-23
6.
Georgian Med News ; (331): 78-84, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36539135

RESUMO

SARS-CoV-2 is the cause of COVID-19 disease and responsible for a pandemic since the 2020. Multiple organ involvement has been described including cutaneous symptoms. Affection of skin appendages, however, seems to be under-reported except for COVID-toes. We performed a PUBMED research for "COVID-19" OR "SARS-CoV-2" AND "skin appendages", "hair", "nails", and "skin glands" from January 2020 to April 2022. COVID toes were excluded since this symptom had extensively been discussed. The focus of this narrative review was laid on clinical presentation, association to the course of COVID-19 disease and treatment options. Skin appendages can be affected by COVID-19 disease beyond COVID-toes, both by symptomatic and asymptomatic course. Telogen effluvium, androgenetic alopecia, and alopecia areata are the most common hair disorders in COVID-19 patients. Nails are less commonly affected by COVID-19 than hair. Splinter hemorrhages and leukonychia are the most frequent findings. While sebaceous glands seem to be uninvolved, SARS-CoV-2 spike proteins have been identified in eccrine sweat glands. Alopecia areata is often seen among asymptomatic COVID-19 patients while telogen effluvium is observed in symptomatic and asymptomatic patients. The half-moon sign on the nails could be a red flag for a more severe course of COVID-19. Treatment options are summarized. Skin appendages are not spared by COVID-19. Their knowledge will help to identify asymptomatic patients and patients at risk for a more severe course of the viral disease.


Assuntos
Alopecia em Áreas , COVID-19 , Dermatopatias , Humanos , SARS-CoV-2 , Pele , Dermatopatias/diagnóstico , Dermatopatias/terapia
7.
Medicina (Kaunas) ; 58(12)2022 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-36556924

RESUMO

Chronic graft-versus-host disease (cGVHD) is a serious complication after allogenic hematopoietic stem cell transplantation (allo-HSCT), negatively affecting the morbidity and mortality of recipients. Skin involvement is the most common cGVHD manifestation with a wide range of pleomorphic features, from scleroderma to ulcerations and microangiopathic changes. Despite the access to many immunosuppressive drugs, therapy for cGVHD is challenging. Systemic steroids are recommended as the first-line treatment; but, in steroid-resistant patients, extracorporeal photopheresis (ECP) remains one of the subsequent therapeutic options. Here, we present a case report of a 31-year patient suffering from advanced steroid-refractory skin and oral mucosa cGVHD who was spectacularly treated with ECP. It was the first time we observed such "overnight" resolution of the graft-versus-host disease syndrome. The present report proves the important role of ECP in the treatment of steroid-resistant cGVHD, especially when other immunosuppressive therapies have failed.


Assuntos
Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Fotoferese , Dermatopatias , Humanos , Fotoferese/efeitos adversos , Doença Enxerto-Hospedeiro/tratamento farmacológico , Doença Enxerto-Hospedeiro/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Dermatopatias/terapia , Dermatopatias/complicações , Esteroides/uso terapêutico , Doença Crônica
8.
J Int Med Res ; 50(12): 3000605221143287, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36565019

RESUMO

This current case report describes a 56-year-old male patient with a skin mass on his lip that had been growing for 1 year. The pathological findings demonstrated that the epidermis was characterized by hyperkeratosis, hyperplasia and hypertrophy and was formed in the shape of a crater. The skin on both ends had developed into a ball-like growth that resembled a volcanic cone. There was invasive growth of heterotype squamous epithelium and a small number of inflammatory cells infiltrating the dermis. Immunohistochemistry demonstrated an increase in P16 (the focus, +) and the hot spot Ki-67 index. The diagnosis was of tumour-like hyperplasia, malignancy and moderate-to-severe dysplasia confirming that it was keratoacanthoma. The patient underwent surgical resection and was discharged from hospital, but the tumour returned. Paclitaxel and cisplatin were administered intraoperatively and bilateral lingual artery perfusion chemoembolization was undertaken six times. This procedure led to an excellent postoperative recovery and discharge from hospital. Tumour therapy was regarded as successful. The patient's medical history included acute lymphoblastic leukaemia L1 and long-term immunosuppressant use. After a 6-month period of follow-up, he died from systemic organ failure as a consequence of having too many ailments.


Assuntos
Carcinoma de Células Escamosas , Ceratoacantoma , Dermatopatias , Neoplasias Cutâneas , Masculino , Humanos , Pessoa de Meia-Idade , Neoplasias Cutâneas/diagnóstico , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/complicações , Hiperplasia/complicações , Ceratoacantoma/cirurgia , Ceratoacantoma/diagnóstico , Dermatopatias/terapia
9.
J Drugs Dermatol ; 21(11): 1260-1263, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342725

RESUMO

Understanding the utility of virtual visits in pediatric dermatology practice has become increasingly important in the telehealth era. We compared the conditions diagnosed in pediatric dermatology between traditional in-person visits and virtual telehealth visits during the initial 8-month phase of the COVID-19 pandemic at an urban medical institution. When given the option, pediatric dermatology patients and their families were more likely to choose telehealth visits for the diagnosis and/or management of acne, hemangiomas, and contact dermatitis; however, they were more likely to choose in-person visits for atopic dermatitis, viral warts, and alopecia areata. These differences may be attributed to clinical features of pediatric skin conditions, treatment options, and other factors which may influence patient preference for telehealth or in-person care for their condition. J Drugs Dermatol. 2022;21(11):1260-1263. doi:10.36849/JDD.6843.


Assuntos
COVID-19 , Dermatologia , Dermatopatias , Telemedicina , Humanos , Criança , COVID-19/epidemiologia , Pandemias , Dermatopatias/diagnóstico , Dermatopatias/epidemiologia , Dermatopatias/terapia
10.
Acta Derm Venereol ; 102: adv00827, 2022 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-36317859

RESUMO

Considering the limited availability of dermatologists to perform live consultations in nursing homes, teledermatology could be used as a triage tool for selection of cases for which live consultations are considered to be of added value compared with teledermatology. This prospective, multicentre observational study aimed to determine the reasons for dermatology consultations in nursing homes and the estimated value of teledermatology as a triage tool, including potential predictors. Skin tumours were the most common reason (n = 161/270; 59.6%) for dermatology consultations in nursing homes. Dermatologists estimated that live consultations added value compared with teledermatology in 67.8% of cases (n = 183). Multivariable logistic regression showed that predictors for this added value of live consultations were: consultations because of a skin tumour; consultations during which a diagnostic or treatment procedure was performed; consultations during which a secondary diagnosis was made; and the dermatologist involved. These results indicate that using teledermatology as a triage tool potentially reduces the need for additional live consultations in one-third of patients, whereas live consultations are estimated to have added value over teledermatology in two-thirds of cases. To make optimal use of the limited capacity for live consultations by dermatologists, it could therefore be helpful if elderly care physicians use teledermatology more frequently.


Assuntos
Dermatologia , Dermatopatias , Neoplasias Cutâneas , Telemedicina , Humanos , Idoso , Dermatologia/métodos , Triagem , Estudos Prospectivos , Neoplasias Cutâneas/diagnóstico , Casas de Saúde , Encaminhamento e Consulta , Dermatopatias/diagnóstico , Dermatopatias/terapia
11.
Eur J Dermatol ; 32(4): 471-479, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-36301747

RESUMO

Background: Usage of modern therapies in the treatment of chronic dermatological diseases has proven to be effective but associated with high costs. High therapy costs might raise legal issues and even lead to recourse claims. Objectives: To evaluate dermatologists' interests and knowledge in medical law and the occurrence of recourse claims, and to assess the impact of medical law on clinical practice. Materials & Methods: Dermatologists of the "Psoriasis-Praxisnetz Süd-West e.V." participated in a web-based questionnaire study investigating the relationship between medical law and usage of modern therapies. The questionnaire was separated in two sub-polls carried out from 11/2016 to 12/2016 and 02/2017 to 03/2017, respectively. The first addressed general topics of medical law and the second specific legal topics, particularly recourse claims. Results: Overall, 76 dermatologists participated in the first and 66 in the second sub-poll. In the first sub-poll, 27.6% of participants attended a seminar on medical law within the last 12 months. Furthermore, 28.8% of the participants of the second sub-poll already experienced a previous recourse claim, and 26.3% of those stated feeling confident or rather confident on legal topics. This proportion was lower among those who had not experienced a recourse claim (17.0%). Overall, 73.7% of those who had a previous recourse claim changed their prescription behaviour as a direct consequence thereof. Conclusion: The study demonstrates a close relationship between medical law issues and the prescription behaviour of dermatologists working in private practices in southern Germany. Regular legal education would thus be beneficial for patient-centred care.


Assuntos
Dermatologia , Psoríase , Dermatopatias , Humanos , Dermatologia/educação , Alemanha , Dermatopatias/terapia , Inquéritos e Questionários
14.
Acta Med Port ; 35(5): 376-383, 2022 May 02.
Artigo em Português | MEDLINE | ID: mdl-36279891

RESUMO

Pregnancy is a period characterized by complex and significant skin changes, which can have a major impact on a woman's life. The cutaneous manifestations associated with this period are usually divided into physiological changes related with pregnancy, pre-existing dermatoses modified by pregnancy, and pregnancy-specific dermatoses, with the latter being potentially associated with significant fetal morbidity. The diagnosis of dermatoses of pregnancy can be challenging due to the variability in its clinical presentation; therefore, a complete and detailed clinical history and a thorough physical examination are essential. Primary care clinicians should be able to recognize these entities and provide some therapeutic strategies, as well as to refer patients whenever there is a risk to the mother and/ or to the fetus. A multidisciplinary team is essential in the evaluation of the most complex entities, and should include dermatologists, pediatricians, obstetricians and family physicians, so that both the mother's symptomatic relief and the minimization of fetal risk can be achieved quick and concurrently.


A gravidez é um período caracterizado por alterações cutâneas significativas e complexas, as quais podem ter um grande impacto na vida da mulher. As manifestações cutâneas associadas a este período dividem-se habitualmente em alterações fisiológicas relacionadas com a gravidez, dermatoses pré-existentes modificadas pela gravidez e dermatoses específicas da gravidez, podendo estas últimas estar associadas a morbidade fetal significativa. O diagnóstico das alterações cutâneas associadas à gravidez pode constituir um desafio devido à variabilidade na sua apresentação clínica, sendo fundamental uma história clínica completa e detalhada e um exame físico minucioso. Os clínicos dedicados aos cuidados de saúde primários devem saber reconhecer estas entidades e providenciar algumas estratégias terapêuticas, bem como referenciar as utentes sempre que exista risco para a mãe e/ou para o feto. Na abordagem das entidades mais complexas é fundamental uma equipa multidisciplinar, envolvendo dermatologistas, pediatras, obstetras e médicos de família, de forma a que se consiga simultânea e rapidamente o alívio sintomático da mãe e a minimização do risco fetal.


Assuntos
Complicações na Gravidez , Dermatopatias , Feminino , Gravidez , Humanos , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/terapia , Dermatopatias/diagnóstico , Dermatopatias/terapia
16.
S D Med ; 75(6): 258-262, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36206566

RESUMO

Dermatologic conditions account for a large proportion of healthcare visits in the United States, yet there continues to be barriers to dermatologic care particularly among the rural and underserved populations. Patients among these populations are particularly vulnerable to poor outcomes and increased morbidity. Teledermatology offers a potential solution to increase access to high-quality dermatologic care. Studies have previously examined the convenience, cost-effectiveness, and clinical efficacy of teledermatology compared to in-person dermatology visits. There is a need to assess which populations are appropriate and in what settings teledermatology can be most effective. We surveyed patients of a South Dakota dermatology practice to assess perceptions and experiences with teledermatology visits in the context of the COVID-19 pandemic. Significant factors leading patients to prefer in-person visits compared to teledermatology were being over the age 65 (OR 2.9 95 percent CI 1.9,3.8 and p-value 0.036) or experiencing technical difficulties during the visit (OR 2.9 95 percent CI 1.9,3.9 and p-value 0.048). We found the chief complaint played an important role in patient preference for visit modality. Patients with acne or acne follow up compared to all other chief complaints had a strong preference for teledermatologic visits (OR 4.7 95 percent CI 4.0,5.4 and p-value 0.000018) whereas patients with possible malignant lesions strongly preferred having an in-person visit (OR 6.6 95 percent CI 5.5,7.8 and p-value 0.0004). Based on these results, we suggest a targeted use of teledermatology with pre-visit screening measures to maintain a patient center approach and avoid redundant visits.


Assuntos
Acne Vulgar , COVID-19 , Dermatologia , Dermatopatias , Telemedicina , Idoso , Dermatologia/métodos , Humanos , Pandemias , Assistência Centrada no Paciente , Dermatopatias/diagnóstico , Dermatopatias/epidemiologia , Dermatopatias/terapia , South Dakota , Estados Unidos
17.
South Med J ; 115(10): 780-783, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36191915

RESUMO

OBJECTIVES: The aim of this study was to examine, from the patient's perspective, the most common reasons for seeking medical attention for skin disease and how this varies among different races. METHODS: We conducted a cross-sectional analysis on the National Ambulatory Medical Care Survey between 2007 and 2018, the most recent years available. The frequency of each reason for visits was determined using the survey procedures of SAS version 9.4. RESULTS: Among White patients, skin cancer screening (8.2%) was the most common reason for visits followed by skin lesions (7.8%) and discoloration/abnormal pigmentation (7.4%). Among Blacks/African Americans, acne (9.2%), progress visit (8.2%), and skin rash (7.0%) were the top reasons for visits. Acne (12%), skin rash (7.5%), and discoloration/abnormal pigmentation (7.3%) were the most common reasons for patient visits in the "other" race category. CONCLUSIONS: Reasons for visits to the dermatologist vary with race. White patients appear to be aware of their increased risk of skin cancer, visiting frequently for skin cancer screenings and skin lesions, whereas Blacks/African Americans are more affected by conditions associated with chronic pruritus. To train dermatologists and nondermatologists to provide equitable care for cutaneous conditions to all races and skin types, especially for those groups experiencing barriers to receiving dermatologic care, it is important that we characterize the reasons why patients visit the dermatologist.


Assuntos
Acne Vulgar , Exantema , Dermatopatias , Neoplasias Cutâneas , Estudos Transversais , Dermatologistas , Humanos , Visita a Consultório Médico , Dermatopatias/diagnóstico , Dermatopatias/epidemiologia , Dermatopatias/terapia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/terapia
20.
Viruses ; 14(9)2022 09 06.
Artigo em Inglês | MEDLINE | ID: mdl-36146777

RESUMO

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a rising concern since its declaration as a pandemic by the World Health Organization on 11 March 2020. Recently, its association with multiple underlying organs has been identified that includes cardiac, renal, gastrointestinal, nervous systems, and cutaneous manifestations. Cutaneous COVID-19 findings have been supposedly classified into the following categories: vesicular (varicella-like), papulo-vesiculsar, chilblains-like ("COVID toes") maculopapular, and urticarial morphologies. In this review, we aim to focus on the proposed pathophysiology behind the various dermatological manifestations associated with COVID-19 and their associated management. We also included prevalence and clinical features of the different COVID-19-related skin lesions in our review. A comprehensive narrative review of the literature was performed in PubMed databases. Data from case reports, observational studies, case series, and reviews till June 2022 were all screened and included in the review.


Assuntos
COVID-19 , Dermatopatias , Humanos , Pandemias , SARS-CoV-2 , Pele/patologia , Dermatopatias/epidemiologia , Dermatopatias/etiologia , Dermatopatias/terapia
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