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1.
Clin Exp Dermatol ; 46(6): 1016-1022, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33882159

RESUMO

Dermatomyositis (DM) is an autoimmune connective tissue disease that is included in the idiopathic inflammatory myopathies. Cutaneous manifestations are a prominent part of the condition: some skin signs in DM are common to most patients, while other signs are encountered infrequently. A number of features are pathognomic for DM. The demonstration of myositis-specific antibodies (MSAs) in DM has extended the ability to define phenotypic subgroups. It appears that the presence of certain MSAs confers susceptibility to specific clinical features, an association which reveals a serotype-phenotype relationship. In this review article we have provided a detailed summary of common and under-recognized cutaneous manifestations of DM.


Assuntos
Dermatomiosite/patologia , Exantema/patologia , Calcinose/etiologia , Dermatomiosite/complicações , Dermatoses Faciais/patologia , Dermatoses da Mão/patologia , Humanos , Dermatoses da Perna/patologia , Paniculite/etiologia , Dermatoses do Couro Cabeludo/patologia , Tronco/patologia
2.
Dermatol Online J ; 27(3)2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33865286

RESUMO

Syringocystadenoma papilliferum is a rare, benign adnexal tumor of eccrine or apocrine origin that typically presents at birth or before puberty. Syringocystadenoma papilliferum is associated with a nevus sebaceus in about 40% of cases. We present a 50-year old woman with a pink-orange plaque and nodule on the scalp, consistent with syringocystadenoma papilliferum that arose within a nevus sebaceus.


Assuntos
Dermatoses do Couro Cabeludo/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenomas Tubulares de Glândulas Sudoríparas/patologia , Biópsia , Feminino , Humanos , Pessoa de Meia-Idade , Dermatoses do Couro Cabeludo/cirurgia , Neoplasias das Glândulas Sudoríparas/cirurgia , Adenomas Tubulares de Glândulas Sudoríparas/cirurgia
4.
Dermatol Online J ; 27(1)2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33560796

RESUMO

Lichen planopilaris is an uncommon dermatological manifestation of lichen planus of the scalp and results in cicatricial alopecia. We present a patient with lichen planopilaris and significant post-inflammatory pigmentary alteration, confirmed by histopathology. The patient's case represents a clinically important variation from an expected typical pattern of dyschromia at periphery of alopecic zones in lichen planopilaris.


Assuntos
Hiperpigmentação/etiologia , Líquen Plano/complicações , Líquen Plano/patologia , Dermatoses do Couro Cabeludo/complicações , Dermatoses do Couro Cabeludo/patologia , Adulto , Fármacos Dermatológicos/uso terapêutico , Diagnóstico Diferencial , Humanos , Hidroxicloroquina/uso terapêutico , Líquen Plano/tratamento farmacológico , Masculino , Prurido/etiologia , Dermatoses do Couro Cabeludo/tratamento farmacológico
7.
J Am Acad Dermatol ; 84(4): 977-988, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32822786

RESUMO

BACKGROUND: Scalp conditions are often multifactorial. OBJECTIVE: To characterize patients with scalp involvement and patch-testing outcomes. METHODS: Retrospective cross-sectional analysis of North American Contact Dermatitis Group data (1996-2016). Study groups included patients with scalp involvement (≤3 anatomic sites coded) with or without additional sites. RESULTS: A total of 4.8% of patients (2331/48,753) had scalp identified as 1 of up to 3 affected anatomic sites. Approximately one-third of "scalp-only" individuals had a specific primary diagnosis of allergic contact dermatitis (38.6%), followed by seborrheic dermatitis (17.2%) and irritant contact dermatitis (9.3%). When adjacent anatomic sites were affected, allergic contact dermatitis was more frequently identified as the primary diagnosis (>50%). The top 5 currently clinically relevant allergens in scalp-only patients were p-phenylenediamine, fragrance mix I, nickel sulfate, balsam of Peru, and cinnamic aldehyde. Methylisothiazolinone sensitivity was notable when adjacent anatomic sites were involved. The top 3 specifically identified sources for scalp-only allergens were hair dyes, shampoo/conditioners, and consumer items (eg, hair appliances, glasses). LIMITATIONS: Tertiary referral population. CONCLUSION: Isolated scalp involvement was less likely to be associated with allergic contact dermatitis than when adjacent anatomic sites were involved. Overlap with multiple diagnoses was frequent, including seborrheic dermatitis, irritant dermatitis, other dermatoses, or all 3. p-Phenylenediamine was the most common allergen.


Assuntos
Dermatite Alérgica de Contato/patologia , Dermatite Irritante/patologia , Testes do Emplastro , Dermatoses do Couro Cabeludo/patologia , Adulto , Idoso , Alérgenos/efeitos adversos , Canadá/epidemiologia , Estudos Transversais , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Dermatite Atópica/patologia , Dermatite Irritante/epidemiologia , Dermatite Irritante/etiologia , Dermatite Seborreica/epidemiologia , Dermatite Seborreica/etiologia , Dermatite Seborreica/patologia , Óculos , Feminino , Tinturas para Cabelo/efeitos adversos , Preparações para Cabelo/efeitos adversos , Humanos , Irritantes/efeitos adversos , Masculino , Pessoa de Meia-Idade , Especificidade de Órgãos , Estudos Retrospectivos , Dermatoses do Couro Cabeludo/epidemiologia , Dermatoses do Couro Cabeludo/etiologia , Estados Unidos/epidemiologia
10.
J Dermatolog Treat ; 32(2): 144-149, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31348693

RESUMO

BACKGROUND: Dissecting cellulitis is a chronic inflammatory dermatosis that results in disfiguring and painful, purulent lesions. Treatment of patients with disease resistant to standard therapies, including intralesional or topical steroids or antibiotics, can be a dilemma for clinicians. METHODS: We performed a systematic review of the literature in November 2018 to find articles which presented treatment options and outcomes of patients who failed prior treatment with standard therapies. RESULTS: We identified 57 articles of interest, with 53 being case studies or series. Isotretinoin was the most often reported, but the response was limited. Biologics and laser therapy were used less often but demonstrated a better chance of remission. X-ray epilation and surgical excision demonstrated the best remission rates but can be complicated by serious morbidity. CONCLUSION: We propose a regimen for the treatment of recalcitrant cases of dissecting cellulitis. In the future, more robust studies including randomized control trials are needed to identify the preferred treatment options for refractory dissecting cellulitis.


Assuntos
Antibacterianos/uso terapêutico , Celulite (Flegmão)/tratamento farmacológico , Dermatoses do Couro Cabeludo/tratamento farmacológico , Dermatopatias Genéticas/tratamento farmacológico , Esteroides/uso terapêutico , Adalimumab/uso terapêutico , Celulite (Flegmão)/patologia , Celulite (Flegmão)/cirurgia , Humanos , Isotretinoína/uso terapêutico , Lasers de Gás/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Fotoquimioterapia , Dermatoses do Couro Cabeludo/patologia , Dermatoses do Couro Cabeludo/cirurgia , Dermatopatias Genéticas/patologia , Dermatopatias Genéticas/cirurgia
14.
Dermatol Online J ; 26(8)2020 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-32941728

RESUMO

Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory condition commonly associated with antecedent iatrogenic insult. EPDS may be diagnostically challenging owing to a lack of pathognomonic histologic findings and cutaneous manifestations that overlap with alternative dermatologic conditions. Therefore, EPDS may be more common than previously recognized. We present a 60-year-old woman with a four-year history of non-healing scalp erosions, progressive skin atrophy, and scarring alopecia despite intravenous antibiotics and intraoperative debridement who improved with systemic glucocorticoids. Our report emphasizes the importance of early recognition of EPDS when delayed wound healing and erosive disease occur in the setting of iatrogenic injury to the scalp. Timely treatment with systemic anti-inflammatory agents is paramount to prevent cicatricial alopecia and mitigate further scalp insult in EPDS.


Assuntos
Anti-Inflamatórios/uso terapêutico , Dermatoses do Couro Cabeludo/diagnóstico , Couro Cabeludo/patologia , Dermatopatias Vesiculobolhosas/diagnóstico , Alopecia/etiologia , Alopecia/patologia , Alopecia/prevenção & controle , Feminino , Humanos , Neoplasias Meníngeas/radioterapia , Neoplasias Meníngeas/cirurgia , Meningioma/radioterapia , Meningioma/cirurgia , Pessoa de Meia-Idade , Furoato de Mometasona/uso terapêutico , Osteomielite/etiologia , Prednisona/uso terapêutico , Radiocirurgia/efeitos adversos , Dermatoses do Couro Cabeludo/tratamento farmacológico , Dermatoses do Couro Cabeludo/patologia , Dermatopatias Vesiculobolhosas/tratamento farmacológico , Dermatopatias Vesiculobolhosas/patologia
17.
Dermatol Online J ; 26(5)2020 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-32621703

RESUMO

Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a cotton-like consistency. This condition is palpable rather than visible. It is a casual finding because it is usually asymptomatic, although it may involve alopecia, pruritus, or dysesthesia. We report a 10-year-old girl with lipedematous scalp without alopecia. Sonographic and MRI findings confirmed the diagnosis of lipidematous scalp.  El lipedema de cuero cabelludo o cuero cabelludo lipedematoso es una entidad infrecuente y de etiología desconocida, rara vez descrita en la edad pediátrica. Se caracteriza por un engrosamiento difuso y de tacto esponjoso del tejido celular subcutáneo localizado principalmente en vértex y occipucio. Suele ser un hallazgo casual dado que habitualmente cursa de forma asintomática, aunque puede asociar alopecia, prurito o disestesias. Presentamos el caso de una niña de 10 años de edad con lipedema de cuero cabelludo sin alopecia asociada. Los hallazgos ecográficos y de resonancia magnética confirmaron el diagnóstico de lipedema de cuero cabelludo.


Assuntos
Lipedema/patologia , Dermatoses do Couro Cabeludo/patologia , Criança , Feminino , Humanos , Lipedema/diagnóstico por imagem , Imageamento por Ressonância Magnética , Couro Cabeludo/patologia , Dermatoses do Couro Cabeludo/diagnóstico por imagem , Ultrassonografia
19.
Ophthalmic Genet ; 41(4): 377-380, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32498638

RESUMO

BACKGROUND: Adams-Oliver syndrome (AOS) is a rare, inherited multi-systemic malformation syndrome characterized by a combination of aplasia cutis congenita and transverse terminal limb defects along with variable involvement of the central nervous system, eyes, and cardiovascular system. AOS can be inherited as both autosomal-dominant and recessive traits. Pathogenic variants in the DOCK6, ARHGAP31, EOGT, RBPJ, DLL4, and NOTCH1 genes have been associated with AOS. PURPOSE: To report a novel homozygous variant in the DOCK6 gene associated with Adams-Oliver syndrome type 2. MATERIALS AND METHODS: Case report. RESULTS: We report a case of a 4-month-old male who presented with microcephaly, global developmental delay, truncal hypotonia, and limb reduction defects. Ophthalmic examination revealed bilateral nystagmus and retinal detachment with mild cataractous changes in addition to retrolental plaque in the left eye. Next generation sequencing analysis identified a novel homozygous frameshift likely pathogenic variant (c.1269_1285dup (p.Arg429Glnfs*32)) in the DOCK6 gene. The constellation of the clinical findings and the genetic mutation were consistent with a diagnosis of AOS type 2. CONCLUSION: The discovery of this new likely pathogenic variant enriches the genotypic spectrum of DOCK6 gene and contributes to genetic diagnosis and counseling of families with AOS. Neurologic and ocular findings appear to be consistent with AOS type 2 for which multidisciplinary clinical evaluation is crucial.


Assuntos
Displasia Ectodérmica/patologia , Fatores de Troca do Nucleotídeo Guanina/genética , Deformidades Congênitas dos Membros/patologia , Mutação , Dermatoses do Couro Cabeludo/congênito , Displasia Ectodérmica/genética , Humanos , Lactente , Deformidades Congênitas dos Membros/genética , Masculino , Fenótipo , Prognóstico , Dermatoses do Couro Cabeludo/genética , Dermatoses do Couro Cabeludo/patologia
20.
An Bras Dermatol ; 95(3): 351-354, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32265056

RESUMO

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. We report a case of osteonevus of Nanta in combined nevus, possibly the first description of this association.


Assuntos
Doenças Ósseas Metabólicas/patologia , Nevo Intradérmico/patologia , Nevo Pigmentado/patologia , Ossificação Heterotópica/patologia , Dermatoses do Couro Cabeludo/patologia , Dermatopatias Genéticas/patologia , Neoplasias Cutâneas/patologia , Adulto , Doenças Ósseas Metabólicas/cirurgia , Feminino , Humanos , Imuno-Histoquímica , Melanócitos/patologia , Nevo Intradérmico/cirurgia , Nevo Pigmentado/cirurgia , Ossificação Heterotópica/cirurgia , Dermatoses do Couro Cabeludo/cirurgia , Dermatopatias Genéticas/cirurgia , Neoplasias Cutâneas/cirurgia
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