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1.
Einstein (Sao Paulo) ; 18: eAO5023, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31994606

RESUMO

OBJECTIVE: To adapt an antibiotic dose adjustment software initially developed in English, to Portuguese and to the Brazilian context. METHODS: This was an observational, descriptive study in which the Delphi method was used to establish consensus among specialists from different health areas, with questions addressing the visual and operational aspects of the software. In a second stage, a pilot experimental study was performed with the random comparison of patients for evaluation and adaptation of the software in the real environment of an intensive care unit, where it was compared between patients who used the standardized dose of piperacillin/tazobactam, and those who used an individualized dose adjusted through the software Individually Designed and Optimized Dosing Strategies. RESULTS: Twelve professionals participated in the first round, whose suggestions were forwarded to the software developer for adjustments, and subsequently submitted to the second round. Eight specialists participated in the second round. Indexes of 80% and 90% of concordance were obtained between the judges, characterizing uniformity in the suggestions. Thus, there was modification in the layout of the software for linguistic and cultural adequacy, minimizing errors of understanding and contradictions. In the second stage, 21 patients were included, and there were no differences between doses of piperacillin in the standard dose and adjusted dose Groups. CONCLUSION: The adapted version of the software is safe and reliable for its use in Brazil.


Assuntos
Anti-Infecciosos/administração & dosagem , Linguística/normas , Piperacilina/administração & dosagem , Desenho de Programas de Computador , Tazobactam/administração & dosagem , Idoso , Idoso de 80 Anos ou mais , Antropometria , Brasil , Comparação Transcultural , Técnica Delfos , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Padrões de Referência , Reprodutibilidade dos Testes , Estatísticas não Paramétricas , Inquéritos e Questionários
2.
J Forensic Nurs ; 16(1): 36-46, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31299671

RESUMO

INTRODUCTION: Corrections agencies are exploring ways to securely and cost-effectively increase access to high-quality, evidence-based educational programs for personnel. Technology-based instructional tools hold strong potential for continuing education. The Institute for Healthcare Improvement's Framework for Going to Full Scale was employed to guide a systematic approach. PURPOSE: The purpose of this article is to outline and describe the design and development of a media-rich interactive computer-based learning product, Enhancing Care for Aged and Dying in Prison, which addresses geriatric and end-of-life care issues in corrections. METHOD: Through an iterative process, the research team developed the computer-based educational program that included program and module-specific objectives in alignment with goals and priorities of the end users, detailed evidence-based content that was engaging and visually appealing, and assessments aimed at testing the user's knowledge. RESULTS: The Enhancing Care for Aged and Dying in Prison contains six modules, created under the careful guidance of the research team and the two advisory boards. Contents, including images and testimonials, were selected purposefully and strategically. Module objectives were developed in alignment with the goals and priorities of each module, and assessments tested user knowledge level pre/post module exposure. Completion of the training product advances the research and development necessary to further the goal of full-scale dissemination of the computer-based education. DISCUSSION/CONCLUSIONS: The goal of this program is to enhance care and improve quality of life for aged and dying inmates. Evidence-based training products are critical in preparing not only forensic nurses who work in corrections but also the broader group of correctional personnel in how to better meet the care needs of incarcerated persons.


Assuntos
Instrução por Computador , Geriatria/educação , Prisioneiros , Desenho de Programas de Computador , Assistência Terminal , Idoso , Humanos , Desenvolvimento de Programas , Interface Usuário-Computador
4.
PLoS One ; 14(12): e0226281, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31887172

RESUMO

Trust between developers influences the success of open source software (OSS) projects. Although existing research recognizes the importance of trust, there is a lack of an effective and scalable computational method to measure trust in an OSS community. Consequently, OSS project members must rely on subjective inferences based on fragile and incomplete information for trust-related decision making. We propose an automated approach to assist a developer in identifying the trustworthiness of another developer. Our two-fold approach, first, computes direct trust between developer pairs who have interacted previously by analyzing their interactions via natural language processing. Second, we infer indirect trust between developers who have not interacted previously by constructing a community-wide developer network and propagating trust in the network. A large-scale evaluation of our approach on a GitHub dataset consisting of 24,315 developers shows that contributions from trusted developers are more likely to be accepted to a project compared to contributions from developers who are distrusted or lacking trust from project members. Further, we develop a pull request classifier that exploits trust metrics to effectively predict the likelihood of a pull request being accepted to a project, demonstrating the practical utility of our approach.


Assuntos
Desenho de Programas de Computador , Confiança , Redes Comunitárias , Tomada de Decisões , Humanos , Relações Interpessoais , Software
5.
Acta Crystallogr D Struct Biol ; 75(Pt 10): 861-877, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31588918

RESUMO

Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop new therapeutics against diseases. The overall structure-solution workflow is similar for these techniques, but nuances exist because the properties of the reduced experimental data are different. Software tools for structure determination should therefore be tailored for each method. Phenix is a comprehensive software package for macromolecular structure determination that handles data from any of these techniques. Tasks performed with Phenix include data-quality assessment, map improvement, model building, the validation/rebuilding/refinement cycle and deposition. Each tool caters to the type of experimental data. The design of Phenix emphasizes the automation of procedures, where possible, to minimize repetitive and time-consuming manual tasks, while default parameters are chosen to encourage best practice. A graphical user interface provides access to many command-line features of Phenix and streamlines the transition between programs, project tracking and re-running of previous tasks.


Assuntos
Automação/métodos , Substâncias Macromoleculares/química , Desenho de Programas de Computador , Validação de Programas de Computador , Microscopia Crioeletrônica/métodos , Cristalografia por Raios X/métodos , Modelos Moleculares , Conformação Molecular
6.
Med. intensiva (Madr., Ed. impr.) ; 43(7): 416-426, oct. 2019. ilus, graf, tab
Artigo em Espanhol | IBECS | ID: ibc-185869

RESUMO

La gran cantidad de información que se procesa informáticamente en el entorno de la medicina intensiva la convierte en un campo ideal para el empleo de técnicas conocidas como Big Data Analysis (BDA) y Machine Learning (ML), que pueden permitir en el futuro mejorar nuestra capacidad de investigación clínica y dirigir de manera más precisa las terapias que proporcionamos a nuestros pacientes. En este artículo se revisan los conceptos fundamentales sobre BDA y ML, y se estudian sus posibles aplicaciones al ámbito de la medicina intensiva, desde un punto de vista del clínico. También se plantean potenciales estrategias para sacar el máximo partido a estas tecnologías emergentes, incluyendo la aparición de un nuevo tipo de profesional sanitario encargado de actuar como enlace entre la parte clínica y la ingeniería de datos


Intensive care is an ideal environment for the use of Big Data Analysis (BDA) and Machine Learning (ML), due to the huge amount of information processed and stored in electronic format in relation to such care. These tools can improve our clinical research capabilities and clinical decision making in the future. The present study reviews the foundations of BDA and ML, and explores possible applications in our field from a clinical viewpoint. We also suggest potential strategies to optimize these new technologies and describe a new kind of hybrid healthcare-data science professional with a linking role between clinicians and data


Assuntos
Humanos , Big Data , Cuidados Críticos/métodos , Aprendizado de Máquina , Estado Terminal , Desenho de Programas de Computador , Processamento de Linguagem Natural , Processamento Eletrônico de Dados/métodos , Armazenamento e Recuperação da Informação , Análise de Dados
7.
Stud Health Technol Inform ; 267: 118-125, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483263

RESUMO

Computerized guidelines have been utilized for several decades by now. Systems based on computerized-guidelines often intertwine (1) medical knowledge representation, (2) guideline procedures and (3) hospital workflows. This induces several drawbacks. Most prominent problems include non-shareability of the computerized guideline between hospitals, limited accessibility of the computerized guideline for humans, and an unclear, often confusing combination of hospital-specific workflow and guideline-induced control flows. This article proposes a 3-layer modelling approach strictly distinguishing the aforementioned three aspects to overcome the respective problems. We applied the 3-layer approach to the implementation of a guideline-interpreting software module in the context of the Medical Informatics Initiative Germany (here: SMITH Project) and comment on the resulting implications for the software design of that module.


Assuntos
Informática Médica , Alemanha , Guias de Prática Clínica como Assunto , Software , Desenho de Programas de Computador , Fluxo de Trabalho
8.
Rev Lat Am Enfermagem ; 27: e3169, 2019 Aug 19.
Artigo em Português, Inglês, Espanhol | MEDLINE | ID: mdl-31432922

RESUMO

OBJECTIVE: To develop a web software prototype to support retirement planning. METHOD: This is a methodological research, applied and based on the principles of prototyping model, which followed the steps of communication, planning, prototype creation, functional tests and consolidation of web software version 1. RESULTS: The functions of the web software prototype were defined from a flowchart and scope. In the creation stage, the screens that integrated the prototype, composed by interview, were projected from the filling of the Retirement Resources Inventory, screen of access to support planning materials, including lectures, scientific texts, and technical materials, retirement news screen, experiences screen, which allow users to post retirement expectations and comment on other users' posts. After performing tests, the prototype was made available at www.aposentarsecomsaude.com.br . CONCLUSION: the web software prototype consists of an interactive environment in which the user feels active in the reflection process about the retirement along the different screens. With clear language and expressions that are easily understood by the public, they are applicable to users of different professional profiles.


Assuntos
Tomada de Decisões , Técnicas de Apoio para a Decisão , Aposentadoria , Desenho de Programas de Computador , Brasil , Instrução por Computador , Humanos , Acontecimentos que Mudam a Vida , Motivação , Sistemas On-Line , Reprodutibilidade dos Testes
9.
Yearb Med Inform ; 28(1): 71-77, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31419818

RESUMO

OBJECTIVES: Despite national mandates, incentives, and other programs, the design of health information technology (IT) remains problematic and usability problems continue to be reported. This paper reviews recent literature on human factors and usability of health IT, with a specific focus on research aimed at applying human factors methods and principles to improve the actual design of health IT, its use, and associated patient and clinician outcomes. METHODS: We reviewed recent literature on human factors and usability problems of health IT and research on human-centered design of health IT for clinicians and patients. RESULTS: Studies continue to show usability problems of health IT experienced by multiple groups of health care professionals (e.g., physicians and nurses) as well as patients. Recent research shows that usability is influenced by both designers (e.g., IT vendors) and implementers in health care organizations, and that the application of human-centered design practices needs to be further improved and extended. We welcome emerging research on the design of health IT for teams as team-based care is increasingly implemented throughout health care. CONCLUSIONS: Progress in the application of human factors methods and principles to the design of health IT is occurring, with important information provided on their actual impact on care processes and patient outcomes. Future research should examine the work of health IT designers and implementers, which would help to develop strategies for further embedding human factors engineering in IT design processes.


Assuntos
Ergonomia , Aplicações da Informática Médica , Humanos , Informática Médica , Segurança do Paciente , Desenho de Programas de Computador
10.
J Cardiovasc Med (Hagerstown) ; 20(9): 584-596, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31369473

RESUMO

: In recent years, three-dimensional modelling and printing techniques have improved diagnosis and preprocedural planning during percutaneous interventions or surgery in cardiovascular disease. The raw data for the whole process are obtained through medical imaging, where regions of interest, that is heart chambers, valves, aorta, coronary vessels etc., are segmented and converted into three-dimensional digital models, which are then reproduced in physical replica by a three-dimensional printer. In the current article, a freeware patient-specific three-dimensional modelling and printing step-by-step procedure for preprocedural planning for complex heart diseases is presented and applied on four patients. Finally, a general discussion on the potential and future developments of personalized three-dimensional modelling and rapid prototyping for preprocedural planning is also presented.


Assuntos
Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/terapia , Tomada de Decisão Clínica , Modelos Anatômicos , Modelos Cardiovasculares , Modelagem Computacional Específica para o Paciente , Impressão Tridimensional , Idoso , Idoso de 80 Anos ou mais , Desenho de Equipamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Seleção de Pacientes , Impressão Tridimensional/instrumentação , Desenho de Programas de Computador
11.
Appl Ergon ; 81: 102892, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31422242

RESUMO

The relationship of Web design attributes (personalisation, structure, navigation, layout, search and performance) and users' personal characteristics to website usability and user satisfaction was investigated among 798 online banking users in Iran. The design and usability of the evaluated websites were not satisfactory from the users' perspectives. Multivariate regression models indicated that Web layout and performance were the main predictors of website usability, while personal characteristics including gender, age and Web usage experience of users had no effect. User satisfaction was also influenced only by the Web design attributes (particularly Web structure) and not by the personal characteristics of the users. There was also a significant relationship between website usability and user satisfaction. The findings suggest that the website designers should focus more on the Web design attributes (particularly Web layout and structure), regardless of the personal characteristics of their users, to improve the usability and user satisfaction of websites.


Assuntos
Conta Bancária/métodos , Comportamento do Consumidor/estatística & dados numéricos , Internet , Interface Usuário-Computador , Adulto , Feminino , Humanos , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Desenho de Programas de Computador
12.
Appl Ergon ; 81: 102891, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31422244

RESUMO

The current study illustrates the icon design process for 20 functions for a smart living room and smart bathroom of a commercial smart building control system. For each function name, seven icon formats (image-related, concept-related, semi-abstract, arbitrary, word, abbreviation, and combined) were developed by 30 graduate students and compared with a preference ranking test by another 13 executive MBA students. The results indicated that the combined, image-related, concept-related, semi-abstract, word, and abbreviation each had nine, four, three, two, one and one function names ranked as the most preferred format, respectively. Since all the design formats except the arbitrary format were ranked as the most preferred at least once, it is worthwhile to generate seven icon formats for a given function and chose the most preferred based on the ranking test result. The participatory design and ranking test evaluation approach can be applied for the design and evaluation of visual icons in other application contexts.


Assuntos
Comportamento do Consumidor , Desenho de Equipamento/psicologia , Semântica , Estudantes/psicologia , Adulto , Feminino , Habitação , Humanos , Masculino , Desenho de Programas de Computador , Toaletes
13.
Kyobu Geka ; 72(5): 338-343, 2019 May.
Artigo em Japonês | MEDLINE | ID: mdl-31268029

RESUMO

PURPOSE: The nutrition support team at our hospital introduced a flowchart to ensure smooth initiation of early enteral nutrition after open heart surgery. We assessed the effectiveness and safety of early enteral nutrition using the flowchart. METHODS: We examined 240 patients who had undergone cardiovascular surgery between November 2013 and September 2015. The patients were divided into 2 groups for comparison;the flowchart intervention group( n=120) and the non-intervention group( n=120). RESULTS: The postoperative enteral nutrition in the intervention and the non-intervention groups was begun at 28.3 (23.2~40.5) hours and 37.0 (26.7~44.9) hours (p=0.04), respectively. There was no difference in the length of intensive care unit stay or postoperative infection rate. However, the length of hospital stay was prolonged in the intervention group (11.0 days versus 9.0 days;p<0.01). The rate of gastrointestinal complication was also comparable( 28% versus 21%;p=0.23). CONCLUSION: Our study suggests that early enteral nutrition may be safely promoted by introducing the flowchart in patients who have undergone open heart surgery. Further investigation is needed to clarify the effectiveness.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Nutrição Enteral , Humanos , Tempo de Internação , Apoio Nutricional , Desenho de Programas de Computador
14.
PLoS One ; 14(7): e0219216, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31291301

RESUMO

Requirement for formation of collaborations has been on increase for the software development industry, especially for smaller to medium sized firms, due to rapid technological advancements, requirements for diversified skills, ever enhancing demands for innovation and fierce competition. Collaborative product development in an alliance enables the firms to benefit from each other's diversified skills and the experience as a result of which they can develop products more rapidly and of better quality as well resulting in a higher payoff. Also, the development costs decrease. However, to avoid undesired results, selection of an appropriate partner firm for collaboration is of utmost importance keeping in view the objectives of alliance formation of both the strategic partners. One-way partner selection techniques available in the literature are impractical as they enable a firm to rank potential partners only from its own perspective while ignoring their objectives. This problem is addressed by the two-way partner selection techniques, however, they either ignore the payoff distribution criteria or the proposed criteria is unfair. More importantly, existing techniques consider that firm collaborate only with the objective to enhance their financial payoff which might not always be the case. The fact that collaborating firms may have one but different objectives for collaboration, or, each may have multiple objectives is largely neglected. To address the scenarios in which firms may collaborate due to multiple and possibly different objectives, this work proposes a bi-objective game-theoretic model that enables a firm to select an appropriate partner based on the individual preferences of both on the following two objectives: 1) learning and 2) financial revenue. Moreover, this model calculates the pay-off that each firm should get whether only monetary, only in the form of learning or both. The calculation of payoff share is based on the following parameters: 1) individual goals of collaboration of partner selecting firms on the said two objectives, 2) their level of cost contribution, 3) cooperation ratio and 4) knowledge investment difference. Comprehensive analysis of various scenarios is done for the proposed Nash Bargaining payoff distribution model to find the optimum strategy of collaborating firms for each scenario.


Assuntos
Indústrias/economia , Investimentos em Saúde/economia , Desenho de Programas de Computador , Software/economia , Teoria do Jogo , Humanos , Modelos Teóricos , Comportamento Social
15.
Appl Ergon ; 80: 175-186, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31280803

RESUMO

The ability of Immersive Virtual Reality (IVR) systems to mimic the real world has made it possible to use this technology to create environments for remote collaborative work. This study aimed to understand the feasibility of immersive virtual reality when conducting a collaborative Information Architecture (IA) design task-card sorting, with geographically dispersed participants. Using a between-subjects experimental design, thirty groups of two individuals each completed a card sorting activity using conventional in-person, video screen-sharing method or immersive virtual reality methods. The dependent measures included total time, percentage match with master card set, usability, presence and perceived workload. Overall usability was found to be significantly higher for the immersive virtual reality condition when compared to conventional in-person card sorting. In addition, the new immersive virtual reality technology performed as well as the other two conditions for other dependent variables. Qualitative data from the participants also indicated a positive reaction to the use of immersive virtual reality for this task. Overall, the participants felt they were productive and enjoyed the IVR condition, indicating the potential of IVR-based approaches as an alternative to conventional approaches for IA design.


Assuntos
Comportamento Cooperativo , Desenho de Programas de Computador , Análise e Desempenho de Tarefas , Interface Usuário-Computador , Realidade Virtual , Adulto , Pesquisa Empírica , Estudos de Viabilidade , Feminino , Processos Grupais , Humanos , Masculino , Pesquisa Qualitativa , Software
16.
BMC Med Inform Decis Mak ; 19(1): 123, 2019 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-31269951

RESUMO

BACKGROUND: The autoverification system for coagulation consists of a series of rules that allow normal data to be released without manual verification. With new advances in medical informatics, the laboratory information system (LIS) has growing potential for the autoverification, allowing rapid and accurate verification of clinical laboratory tests. The purpose of the study is to develop and evaluate a LIS-based autoverification system for validation and efficiency. METHODS: Autoverification decision rules, including quality control, analytical error flag, critical value, limited range check, delta check and logical check, as well as patient's historical information, were integrated into the LIS. Autoverification limited range was constructed based on 5 and 95% percentiles. The four most commonly used coagulation assays, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FBG), were followed by the autoverification protocols. The validation was assessed by the autoverification passing rate, the true-positive cases, the true-negative cases, the false-positive cases, the false-negative cases, the sensitivity and the specificity; the efficiency was evaluated in the turnaround time (TAT). RESULTS: A total of 157,079 historical test results of coagulation profiles from January 2016 to December 2016 were collected to determine the distribution intervals. The autoverification passing rate was 77.11% (29,165/37,821) based on historical patient data. In the initial test of the autoverification version in June 2017, the overall autoverification passing rate for the whole sample was 78.75% (11,257/14,295), with 892 true-positive cases, 11,257 true-negative cases, 2146 false-positive cases, no false-negative cases, sensitivity of 100% and specificity of 83.99%. After formal implementation of the autoverification system for 6 months, 83,699 samples were assessed. The average overall autoverification passing rate for the whole sample was 78.86% and the 95% confidence interval (CI) of the passing rate was [78.25, 79.59%]. TAT was reduced from 126 min to 101 min, which was statistically significant (P < 0.001, Mann-Whitney U test). CONCLUSIONS: The autoverification system for coagulation assays based on LIS can halt the samples with abnormal values for manual verification, guarantee medical safety, minimize the requirements for manual work, shorten TAT and raise working efficiency.


Assuntos
Testes de Coagulação Sanguínea , Sistemas de Informação em Laboratório Clínico , Técnicas de Laboratório Clínico , Aplicações da Informática Médica , Segurança , Testes de Coagulação Sanguínea/normas , Sistemas de Informação em Laboratório Clínico/normas , Técnicas de Laboratório Clínico/normas , Humanos , Segurança/normas , Desenho de Programas de Computador
17.
JMIR Mhealth Uhealth ; 7(7): e13194, 2019 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-31278732

RESUMO

BACKGROUND: A personal health record (PHR) system encourages patients to engage with their own health care by giving them the ability to manage and keep track of their own health data. Of the numerous PHR systems available in the market, many are Web-based patient portals and a few are mobile apps. They have mainly been created by hospitals and electronic health record (EHR) vendors. One major limitation of these hospital-created PHR systems is that patients can only view specific health data extracted from their EHR. Patients do not have the freedom to add important personal health data they collect in their daily lives into their PHR. Therefore, there is an information gap between clinical visits. OBJECTIVE: The aim of this study was to develop and evaluate a new mobile PHR app that can be easily used to manage various types of personal health data to fill the information gap. METHODS: A user-centered approach was used to guide the development and evaluation of the new mobile PHR app. There were three steps in this study: needs assessment, app design and development, and conducting a usability study. First, a large-scale questionnaire study was conducted with the general population to gain an understanding of their needs and expectations with regard to a mobile PHR app. A mobile PHR app for personal medical data tracking and management was then created based on the results of the questionnaire study. End users were actively involved in all stages of the app development. Finally, a usability study was performed with participants to evaluate the usability of the mobile PHR app, which involved asking participants to finish a set of tasks and to respond to a usability questionnaire. RESULTS: In the questionnaire study for needs assessment, there were 609 participants in total. The answers from these participants revealed that they wanted to manage various types of personal health data in a mobile PHR app. Participants also reported some features they desired to have in the app. On the basis of the needs assessment findings, a new mobile PHR app (PittPHR) was created with 6 major modules: health records, history, trackers, contacts, appointments, and resources. This app allows users to customize the trackers according to their needs. In the usability study, there were 15 participants. The usability study participants expressed satisfaction with the app and provided comments and suggestions for further development. CONCLUSIONS: This new mobile PHR app provides options for users to manage a wide range of personal health data conveniently in one place. The app fills the information gap between clinical visits. The study results indicated that this new mobile PHR app meets the need of users and that users welcome this app.


Assuntos
Registros Eletrônicos de Saúde/instrumentação , Aplicativos Móveis/normas , Assistência Centrada no Paciente/métodos , Adolescente , Adulto , Registros Eletrônicos de Saúde/normas , Registros Eletrônicos de Saúde/estatística & dados numéricos , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Aplicativos Móveis/estatística & dados numéricos , Determinação de Necessidades de Cuidados de Saúde/normas , Determinação de Necessidades de Cuidados de Saúde/estatística & dados numéricos , Desenho de Programas de Computador , Inquéritos e Questionários
18.
Genes (Basel) ; 10(7)2019 07 22.
Artigo em Inglês | MEDLINE | ID: mdl-31336684

RESUMO

Understanding chromatin interactions is important because they create chromosome conformation and link the cis- and trans- regulatory elements to their target genes for transcriptional regulation. Chromatin Interaction Analysis with Paired-End Tag (ChIA-PET) sequencing is a genome-wide high-throughput technology that detects chromatin interactions associated with a specific protein of interest. We developed ChIA-PET Tool for ChIA-PET data analysis in 2010. Here, we present the updated version of ChIA-PET Tool (V3) as a computational package to process the next-generation sequence data generated from ChIA-PET experiments. It processes short-read and long-read ChIA-PET data with multithreading and generates statistics of results in an HTML file. In this paper, we provide a detailed demonstration of the design of ChIA-PET Tool V3 and how to install it and analyze RNA polymerase II (RNAPII) ChIA-PET data from human K562 cells with it. We compared our tool with existing tools, including ChiaSig, MICC, Mango and ChIA-PET2, by using the same public data set in the same computer. Most peaks detected by the ChIA-PET Tool V3 overlap with those of other tools. There is higher enrichment for significant chromatin interactions from ChIA-PET Tool V3 in aggregate peak analysis (APA) plots. The ChIA-PET Tool V3 is publicly available at GitHub.


Assuntos
Cromatina , Técnicas Genéticas , Software , Humanos , Dados de Sequência Molecular , Desenho de Programas de Computador
19.
Rev Bras Enferm ; 72(3): 680-686, 2019 Jun 27.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31269132

RESUMO

OBJECTIVE: to develop a software that allows the nurse of the surgical center to plan intraoperative nursing care through electronic access to the work routines of his/her team. METHOD: the methodological course was carried out according to systems development theory, which guides five basic activities: communication, planning, modeling, developing and delivery of the product. RESULTS: the activities and functions of the software were arranged in five modules, containing information regarding the inputs and the step-by-step involving the assembly, circulation and disassembly of the operating room to perform the various anesthetic and surgical procedures. FINAL CONSIDERATIONS: The developed software will allow the surgical center's nursing team to access its intraoperative routines in a fast and systematic way, since this allowed to concentrate all the routines of assembly, circulation and disassembly of operating room in a safe space and accessible.


Assuntos
Cuidados Intraoperatórios/enfermagem , Equipe de Assistência ao Paciente/tendências , Desenho de Programas de Computador , Comunicação , Continuidade da Assistência ao Paciente/normas , Humanos , Cuidados Intraoperatórios/tendências , Teoria de Sistemas , Interface Usuário-Computador
20.
Games Health J ; 8(4): 275-284, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31219347

RESUMO

Objective: Digital health technologies most often reach only those more motivated to engage, particularly when preventive health is targeted. To test whether gamification could be used to engage low-motivation smokers, we conceptualized "Take a Break"-a 3-week technology-assisted challenge for smokers to compete in setting and achieving brief abstinence goals. Materials and Methods: In the feasibility study of the multi-technology Take a Break challenge, low-motivation smokers were given (1) daily motivational messages, (2) brief "challenge quizzes" related to smoking behaviors, (3) a telehealth call to personalize their abstinence goal for the challenge, (4) "coping minigames" to help manage cravings while attempting to achieve their brief abstinence goals, and (5) a leaderboard "webApp," providing comparative feedback on smokers' participation, and allowing for competition. Heterogeneity of engagement was tracked. Results: All 41 smokers initially reported that they were not actively quitting. Over half were employed less than full time (51%), completed less than a 4-year college education (76%), and experienced financial stress (54%). No smokers opted out of the motivational messages, and mean proportion of response to the challenge quizzes was 0.88 (SD = 0.19). Half of the smokers reported using the "coping minigames." Almost all set abstinence goals (78%), with over half lasting 1-2 days (51%); median = 1 day (IQR 1-7). Leaderboard points ranged widely. Conclusions: Rates of smoking in the developed world have declined, and those who remain smokers are complex and have lower motivation to quit. Using a game-inspired challenge, we achieved high levels of engagement from low-motivation smokers.


Assuntos
Promoção da Saúde/normas , Fumantes/psicologia , Abandono do Hábito de Fumar/psicologia , Desenho de Programas de Computador , Adulto , Estudos de Viabilidade , Feminino , Promoção da Saúde/métodos , Promoção da Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Fumantes/educação , Fumantes/estatística & dados numéricos , Abandono do Hábito de Fumar/métodos , Abandono do Hábito de Fumar/estatística & dados numéricos
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