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1.
Int J Mol Sci ; 22(12)2021 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-34204387

RESUMO

In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity of the skeletal system. When cellular activities of osteoclasts and osteoblasts become abnormal, pathological bone conditions, such as osteoporosis, can occur. Traditional imaging modalities, such as radiographs, are insensitive to the early cellular changes that precede gross pathological findings, often leading to delayed disease diagnoses and suboptimal therapeutic strategies. 18F-sodium fluoride (18F-NaF)-positron emission tomography (PET) is an emerging imaging modality with the potential for early diagnosis and monitoring of bone diseases through the detection of subtle metabolic changes. Specifically, the dissociated 18F- is incorporated into hydroxyapatite, and its uptake reflects osteoblastic activity and bone perfusion, allowing for the quantification of bone turnover. While 18F-NaF-PET has traditionally been used to detect metastatic bone disease, recent literature corroborates the use of 18F-NaF-PET in benign osseous conditions as well. In this review, we discuss the cellular mechanisms of 18F-NaF-PET and examine recent findings on its clinical application in diverse metabolic, autoimmune, and osteogenic bone disorders.


Assuntos
Doenças Ósseas/diagnóstico , Doenças Ósseas/etiologia , Radioisótopos de Flúor , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Fluoreto de Sódio , Animais , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/etiologia , Doenças Autoimunes/metabolismo , Biomarcadores , Doenças Ósseas/metabolismo , Doenças Ósseas Metabólicas/diagnóstico , Doenças Ósseas Metabólicas/etiologia , Doenças Ósseas Metabólicas/metabolismo , Diagnóstico Diferencial , Diagnóstico por Imagem/métodos , Gerenciamento Clínico , Suscetibilidade a Doenças , Humanos , Tomografia por Emissão de Pósitrons/métodos
2.
Molecules ; 26(12)2021 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-34203597

RESUMO

We used Raman micro-spectroscopy technique to analyze the molecular changes associated with oral squamous cell carcinoma (SCC) cells in the form of frozen tissue. Previously, Raman micro-spectroscopy technique on human tissue was mainly based on spectral analysis, but we worked on imaging of molecular structure. In this study, we evaluated the distribution of four components at the cell level (about 10 µm) to describe the changes in protein and molecular structures of protein belonging to malignant tissue. We analyzed ten oral SCC samples of five patients without special pretreatments of the use of formaldehyde. We obtained cell level images of the oral SCC cells at various components (peak at 935 cm-1: proline and valine, 1004 cm-1: phenylalanine, 1223 cm-1: nucleic acids, and 1650 cm-1: amide I). These mapping images of SCC cells showed the distribution of nucleic acids in the nuclear areas; meanwhile, proline and valine, phenylalanine, and amide I were detected in the cytoplasm areas of the SCC cells. Furthermore, the peak of amide I in the cancer area shifts to the higher wavenumber side, which indicates the α-helix component may decrease in its relative amounts of protein in the ß-sheet or random coil conformation. Imaging of SCC cells with Raman micro-spectroscopy technique indicated that such a new observation of cancer cells is useful for analyzing the detailed distribution of various molecular conformation within SCC cells.


Assuntos
Análise Espectral Raman/métodos , Carcinoma de Células Escamosas de Cabeça e Pescoço/diagnóstico por imagem , Carcinoma de Células Escamosas/diagnóstico por imagem , Carcinoma de Células Escamosas/patologia , Núcleo Celular/metabolismo , Citoplasma/metabolismo , Diagnóstico por Imagem/métodos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Japão , Conformação Molecular , Neoplasias Bucais/diagnóstico por imagem , Neoplasias Bucais/metabolismo , Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia
3.
Nat Commun ; 12(1): 3710, 2021 06 17.
Artigo em Inglês | MEDLINE | ID: mdl-34140475

RESUMO

The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.


Assuntos
Técnicas Biossensoriais/instrumentação , Técnicas Biossensoriais/métodos , Diagnóstico por Imagem/métodos , Infarto do Miocárdio/diagnóstico por imagem , Pericárdio/diagnóstico por imagem , Animais , Materiais Biocompatíveis/química , Linhagem Celular , Modelos Animais de Doenças , Eletrocardiografia , Fenômenos Eletrofisiológicos , Processamento de Imagem Assistida por Computador , Tinta , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Simulação de Dinâmica Molecular , Mioblastos/metabolismo , Mioblastos/patologia , Próteses e Implantes , Silicones/química , Análise Espaço-Temporal , Suínos , Ultrassonografia
4.
Medicine (Baltimore) ; 100(26): e26534, 2021 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-34190190

RESUMO

ABSTRACT: Many previous studies have estimated the rate of dopaminergic denervation in Parkinson disease (PD) via imaging studies. However, they lack the considerations of onset age, disease duration at onset, gender, and dopaminergic denervation due to normal aging. Herein, using a large prospective cohort, we estimated the rate of dopaminergic denervation in PD patients, compared with an age- and gender-matched normal control group.One hundred forty-one normal controls and 301 PD patients were enrolled. Striatal specific binding ratios (SBRs) of I-123 FP-CIT single positron emission tomography images were analyzed according to the age of onset, gender, and the duration of motor symptoms.In the PD group, symptom duration was significantly correlated with caudate SBRs, but with putamen SBRs (P  < .05, R2 = 0.02). Moreover, was significantly inversely related to caudate SBRs, but not with putamen SBRs (P  < .05, R2 = 0.02). Patients of different age onsets did not show any significant correlation between symptom durations and striatal SBRs. In the age-matched group, no significant relationship was observed between symptom duration and percent decrease of caudate SBRs, but there was a significant relationship between symptom duration and percent decrease of the putamen SBRs (P  < .01, R2 = 0.06). There was no significant relationship between the symptom duration and the percent decrease of striatal SBRs in the age- and gender-matched group.The significance and R2 values from the regression analysis between symptom duration, age, and dopaminergic denervation are low. This suggests that, contrary to previous knowledge, there is a relatively weak association between dopaminergic denervation and age or symptom duration.


Assuntos
Corpo Estriado , Diagnóstico por Imagem , Dopamina/metabolismo , Neurônios Dopaminérgicos , Degeneração Neural , Doença de Parkinson , Idade de Início , Biomarcadores/análise , Corpo Estriado/diagnóstico por imagem , Corpo Estriado/metabolismo , Diagnóstico por Imagem/classificação , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/estatística & dados numéricos , Progressão da Doença , Neurônios Dopaminérgicos/metabolismo , Neurônios Dopaminérgicos/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Degeneração Neural/diagnóstico , Degeneração Neural/fisiopatologia , Doença de Parkinson/diagnóstico , Doença de Parkinson/epidemiologia , Doença de Parkinson/metabolismo , Doença de Parkinson/fisiopatologia , Gravidade do Paciente , República da Coreia/epidemiologia , Avaliação de Sintomas/métodos , Tomografia Computadorizada de Emissão de Fóton Único/métodos
5.
Nat Commun ; 12(1): 3552, 2021 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-34117241

RESUMO

Important dynamic processes in mechanobiology remain elusive due to a lack of tools to image the small cellular forces at play with sufficient speed and throughput. Here, we introduce a fast, interference-based force imaging method that uses the illumination of an elastic deformable microcavity with two rapidly alternating wavelengths to map forces. We show real-time acquisition and processing of data, obtain images of mechanical activity while scanning across a cell culture, and investigate sub-second fluctuations of the piconewton forces exerted by macrophage podosomes. We also demonstrate force imaging of beating neonatal cardiomyocytes at 100 fps which reveals mechanical aspects of spontaneous oscillatory contraction waves in between the main contraction cycles. These examples illustrate the wider potential of our technique for monitoring cellular forces with high throughput and excellent temporal resolution.


Assuntos
Diagnóstico por Imagem/métodos , Mecanotransdução Celular/fisiologia , Microscopia de Interferência/métodos , Animais , Adesão Celular , Fibroblastos/citologia , Humanos , Macrófagos/citologia , Camundongos , Modelos Teóricos , Células NIH 3T3 , Podossomos/metabolismo
6.
J Pediatr Orthop ; 41(Suppl 1): S75-S79, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34096542

RESUMO

INTRODUCTION: Pediatric orthopaedic patients have the potential for significant radiation exposure from the use of imaging studies, such as computed tomography and bone scintigraphy. With the potential for long-term treatment, such as is required for scoliosis or osteogenesis imperfecta, patients are at even greater risk of radiation-induced carcinogenesis. DISCUSSION: Although an association between radiation and cancer risk is evident, causation is difficult to prove because comorbidities or genetic predispositions may play a role in the higher baseline rates of malignancy later in life. Efforts have been made over the years to reduce exposure using more modern imaging techniques and simple radiation reduction strategies. Educational efforts and clinical practice guidelines are decreasing the rate of computed tomography scan use in pediatrics. Although considerable work is being done on the development of radiation-free imaging modalities, imaging that uses ionizing radiation will, in the near term, be necessary in specific circumstances to provide optimal care to pediatric orthopaedic patients. CONCLUSION: Knowledge of the ionizing radiation exposure associated with commonly used tests as well as radiation-reduction strategies is essential for the optimal and safe care of pediatric orthopaedic patients.


Assuntos
Diagnóstico por Imagem , Ortopedia , Pediatria , Exposição à Radiação , Criança , Diagnóstico por Imagem/efeitos adversos , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/normas , Humanos , Ortopedia/métodos , Ortopedia/normas , Pediatria/métodos , Pediatria/normas , Exposição à Radiação/efeitos adversos , Exposição à Radiação/prevenção & controle , Saúde Radiológica/métodos , Saúde Radiológica/normas , Risco Ajustado/métodos , Tomografia Computadorizada por Raios X/métodos
7.
Pediatr Radiol ; 51(6): 1076-1078, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33999248

RESUMO

It seems paradoxical that facts, data and science are still considered controversial despite the harrowing death of a multitude of people from coronavirus disease 2019 (COVID-19), an unparalleled health care crisis of our lifetime. In addition, while scientists are desperately attempting to produce a vaccine for COVID-19, a large segment of the populace still believes in conspiracies related to vaccines. Therefore, it is not surprising that the diagnosis of abusive head trauma (AHT) faces similar challenges - the difference being that AHT challenges are mostly in the realms of law courts rather than actual clinical management of these infants. Against this backdrop, the Child Abuse Imaging Committee of the Society for Pediatric Radiology (SPR) collaborated with other leading experts to develop the consensus statement on AHT. This consensus statement has had a significant impact since its publication. It is now endorsed by 17 multinational, multidisciplinary organizations. The consensus statement has helped educate the diverse stakeholders of AHT and has helped further our understanding of AHT and the issues related to it. This could serve as the template for developing future consensus documents.


Assuntos
Maus-Tratos Infantis/diagnóstico , Consenso , Traumatismos Craniocerebrais/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Criança , Pré-Escolar , Humanos , Lactente , Pediatria , Radiologia , Sociedades Médicas
8.
Methods Mol Biol ; 2274: 155-168, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34050470

RESUMO

Sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases (HDACs). In mammals, dysfunction of SIRTs is associated with age-related metabolic diseases, cancers, and even aging. Therefore, the detection of SIRT activity in living cells or tissues would be helpful for diagnosis of a wide range of SIRT-associated diseases. Here, we present methodology to measure SIRT activity in living cells by using our newly developed SIRT fluorescence probe, KST-F-DA.


Assuntos
Diagnóstico por Imagem/métodos , Corantes Fluorescentes/análise , Microscopia de Fluorescência/métodos , Sirtuína 1/metabolismo , Inibidores Enzimáticos/farmacologia , Corantes Fluorescentes/química , Células HEK293 , Humanos , Sirtuína 1/antagonistas & inibidores
9.
Methods Mol Biol ; 2274: 181-192, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34050472

RESUMO

Fluorescent ligands have emerged as powerful tools for noninvasive research of G protein-coupled receptors (GPCRs), since they could provide the invaluable information regarding GPCRs' structure and function in vitro. However, the in vivo applications of thus tools are hampered owing to their short-wavelength spectra and lack of fluorogenic switch. Here, we describe the experimental details of discovery of the environment-sensitive near-infrared (NIR) fluorogenic ligand for in vivo imaging of α1-adrenergic receptor (α1-AR).


Assuntos
Diagnóstico por Imagem/métodos , Corantes Fluorescentes/química , Proteínas de Fluorescência Verde/metabolismo , Neoplasias/patologia , Receptores Adrenérgicos alfa 1/metabolismo , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Animais , Feminino , Humanos , Masculino , Camundongos Nus , Neoplasias/diagnóstico por imagem , Neoplasias/metabolismo , Células Tumorais Cultivadas , Ensaios Antitumorais Modelo de Xenoenxerto
10.
Methods Mol Biol ; 2274: 193-206, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34050473

RESUMO

Fluorescence (FL)-guided detection of cancer is one of the most promising approaches to achieve intraoperative assessment of surgical margins. Enzymes, such as aminopeptidase, carboxypeptidase, and glycosidase, whose activities are increased in cancer, have attracted great interest as imaging targets for rapid and sensitive visualization of cancerous tissues with fluorescent probes. Activatable probes, which are initially nonfluorescent but become strongly fluorescent upon rapid one-step cleavage of their substrate moiety by the target enzyme, are especially promising for practical clinical application during surgical or endoscopic procedures due to the highly amplified FL change generated by enzyme-catalyzed turnover at lesion sites. Here, we describe robust protocols for using activatable fluorescent probes targeting cancer-associated enzyme activities to visualize cultured cancer cells, metastatic cancer in a mouse model, and cancerous lesions in surgical specimens from patients.


Assuntos
Aminopeptidases/metabolismo , Carboxipeptidases/metabolismo , Diagnóstico por Imagem/métodos , Corantes Fluorescentes/química , Neoplasias/patologia , Neoplasias Peritoneais/secundário , Animais , Feminino , Humanos , Masculino , Camundongos Endogâmicos BALB C , Camundongos Nus , Microscopia Confocal , Neoplasias/diagnóstico por imagem , Neoplasias/enzimologia , Neoplasias Peritoneais/diagnóstico por imagem , Neoplasias Peritoneais/enzimologia , Células Tumorais Cultivadas , Ensaios Antitumorais Modelo de Xenoenxerto
11.
Pediatr Radiol ; 51(6): 1076-1078, 2021 05.
Artigo em Inglês | MEDLINE | ID: covidwho-1230231

RESUMO

It seems paradoxical that facts, data and science are still considered controversial despite the harrowing death of a multitude of people from coronavirus disease 2019 (COVID-19), an unparalleled health care crisis of our lifetime. In addition, while scientists are desperately attempting to produce a vaccine for COVID-19, a large segment of the populace still believes in conspiracies related to vaccines. Therefore, it is not surprising that the diagnosis of abusive head trauma (AHT) faces similar challenges - the difference being that AHT challenges are mostly in the realms of law courts rather than actual clinical management of these infants. Against this backdrop, the Child Abuse Imaging Committee of the Society for Pediatric Radiology (SPR) collaborated with other leading experts to develop the consensus statement on AHT. This consensus statement has had a significant impact since its publication. It is now endorsed by 17 multinational, multidisciplinary organizations. The consensus statement has helped educate the diverse stakeholders of AHT and has helped further our understanding of AHT and the issues related to it. This could serve as the template for developing future consensus documents.


Assuntos
Maus-Tratos Infantis/diagnóstico , Consenso , Traumatismos Craniocerebrais/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Criança , Pré-Escolar , Humanos , Lactente , Pediatria , Radiologia , Sociedades Médicas
12.
Int J Comput Assist Radiol Surg ; 16(7): 1121-1129, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33966168

RESUMO

PURPOSE: Estimating uncertainty in predictions made by neural networks is critically important for increasing the trust medical experts have in automatic data analysis results. In segmentation tasks, quantifying levels of confidence can provide meaningful additional information to aid clinical decision making. In recent work, we proposed an interpretable uncertainty measure to aid clinicians in assessing the reliability of developmental dysplasia of the hip metrics measured from 3D ultrasound screening scans, as well as that of the US scan itself. In this work, we propose a technique to quantify confidence in the associated segmentation process that incorporates voxel-wise uncertainty into the binary loss function used in the training regime, which encourages the network to concentrate its training effort on its least certain predictions. METHODS: We propose using a Bayesian-based technique to quantify 3D segmentation uncertainty by modifying the loss function within an encoder-decoder type voxel labeling deep network. By appending a voxel-wise uncertainty measure, our modified loss helps the network improve prediction uncertainty for voxels that are harder to train. We validate our approach by training a Bayesian 3D U-Net with the proposed modified loss function on a dataset comprising 92 clinical 3D US neonate scans and test on a separate hold-out dataset of 24 patients. RESULTS: Quantitatively, we show that the Dice score of ilium and acetabulum segmentation improves by 5% when trained with our proposed voxel-wise uncertainty loss compared to training with standard cross-entropy loss. Qualitatively, we further demonstrate how our modified loss function results in meaningful reduction of voxel-wise segmentation uncertainty estimates, with the network making more confident accurate predictions. CONCLUSION: We proposed a Bayesian technique to encode voxel-wise segmentation uncertainty information into deep neural network optimization, and demonstrated how it can be leveraged into meaningful confidence measures to improve the model's predictive performance.


Assuntos
Teorema de Bayes , Diagnóstico por Imagem/métodos , Luxação Congênita de Quadril/diagnóstico , Processamento de Imagem Assistida por Computador/métodos , Redes Neurais de Computação , Criança , Humanos , Reprodutibilidade dos Testes , Incerteza
13.
J Clin Neurosci ; 89: 437-447, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34052071

RESUMO

Dedicated post-operative radiological evaluation following ophthalmologic procedures is relatively uncommon. However, given the ever-growing ophthalmologic procedural advancements and the increasing utilization of neuroimaging for myriad indications, the orbits are often imaged incidentally in a delayed post-procedural state. Regardless of the clinical scenario, it is important for neuroradiologists and other specialists commonly exposed to orbital imaging to be aware of both expected and abnormal post-operative imaging findings because misinterpreted normal features or unrecognized complications can result in vision-threatening delays in treatment or mismanagement. In this review article, we discuss many common ophthalmologic procedures, their indications, and most likely complications. We also provide illustrative operative photographs and radiological imaging examples. By understanding the surgical intent, recognizing the devices that are commonly used, and developing familiarity with the appearance of post-operative complications, pitfalls in interpretation can be avoided and patient outcomes ultimately improved.


Assuntos
Diagnóstico por Imagem/métodos , Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos , Órbita/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Humanos , Órbita/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia
14.
Radiol Clin North Am ; 59(4): 501-509, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053601

RESUMO

"Incidentalomas" are a common part of daily practice for radiologists, and knowledge of appropriate management guidelines is important in ensuring that no potentially clinically relevant findings are missed or are lost to follow-up in asymptomatic patients. Incidental findings of the brain, spine, thyroid, lungs, breasts, liver, adrenals, spleen, pancreas, kidneys, bowel, and ovaries are discussed, including where to find guidelines for management recommendations, how to follow them, and medical-legal considerations.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Neoplasias/diagnóstico por imagem , Guias de Prática Clínica como Assunto , Humanos , Jurisprudência , Neoplasias/terapia
15.
Radiol Clin North Am ; 59(4): 525-533, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053603

RESUMO

Incidental thyroid nodules (ITNs) are commonly detected on imaging examinations performed for other reasons, particularly computed tomography (CT) (and now PET-CT and even PET-MR imaging), MR imaging, and sonography, primarily a consequence of the increasing sensitivity of these diagnostic modalities. Appropriate management of ITNs is crucial to avoid the cost and medical consequences of unnecessary workups.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/terapia , Humanos , Glândula Tireoide/diagnóstico por imagem
16.
Radiol Clin North Am ; 59(4): 591-601, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053607

RESUMO

Incidentally detected adrenal nodules are common, and prevalence increases with patient age. Although most are benign, it is important for the radiologist to be able to accurately determine which nodules require further testing and which are safely left alone. The American College of Radiology incidental adrenal White Paper provides a structured algorithm based on expert consensus for management of incidental adrenal nodules. If further diagnostic testing is indicated, adrenal computed tomography is the most appropriate test in patients for nodules less than 4 cm. In addition to imaging, biochemical testing and endocrinology referral is warranted to exclude a functioning mass.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Achados Incidentais , Glândulas Suprarrenais/diagnóstico por imagem , Humanos
17.
Radiol Clin North Am ; 59(4): 603-616, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053608

RESUMO

Incidental splenic focal findings are commonly encountered in clinical practice and frequently represent a diagnostic dilemma due to nonspecific imaging features. Most are benign, particularly in patients without a history of malignancy and without symptoms of fever, weight loss, or left upper quadrant or epigastric pain. Incidental malignant splenic processes are exceedingly rare. This article reviews imaging characteristics of incidental focal splenic findings, and proposes a practical approach for management of such findings, which can prevent unnecessary workup and its related drawbacks in clinical practice.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Esplenopatias/diagnóstico por imagem , Humanos , Baço/diagnóstico por imagem
18.
Radiol Clin North Am ; 59(4): 617-629, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053609

RESUMO

Incidental pancreatic cysts are commonly encountered in radiology practice. Although some of these are benign, mucinous varieties have a potential to undergo malignant transformation. Characterization of some incidental pancreatic cysts based on imaging alone is limited, and given that some pancreatic cysts have a malignant potential, various societies have created guidelines for the management and follow-up of incidental pancreatic cysts. This article reviews the imaging findings and work-up of pancreatic cysts and gives an overview of the societal guidelines for the management and follow-up of incidental pancreatic cysts.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Cisto Pancreático/diagnóstico por imagem , Humanos , Pâncreas/diagnóstico por imagem
19.
Radiol Clin North Am ; 59(4): 631-646, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053610

RESUMO

Renal masses are commonly encountered on cross-sectional imaging examinations performed for nonrenal indications. Although most can be dismissed as benign cysts, a subset will be either indeterminate or suspicious; in many cases, imaging cannot be used to reliably differentiate between benign and malignant masses. On-going research in defining characteristics of common renal masses on advanced imaging shows promise in offering solutions to this issue. A recent update of the Bosniak classification (used to categorize cystic renal masses) was proposed with the goals of decreasing imaging follow-up in likely benign cystic masses, and therefore avoiding unnecessary surgical resection of such masses.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Neoplasias Renais/diagnóstico por imagem , Neoplasias Renais/terapia , Humanos , Rim/diagnóstico por imagem
20.
Radiol Clin North Am ; 59(4): 661-692, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34053612

RESUMO

Incidental adnexal masses and uterine findings occur with a high frequency on cross-sectional imaging examinations, particularly in postmenopausal women in whom imaging is performed for a different reason. These incidentalomas encompass a gamut of potential pelvic gynecologic disorders. Most are benign ovarian cysts; however, other less commonly encountered disorders and improperly positioned gynecologic devices may be seen. A knowledge of the management recommendations for such pelvic incidental findings is critical to avoid unnecessary imaging and surgical interventions, as well as to avoid failure in diagnosis and management of some of these conditions.


Assuntos
Diagnóstico por Imagem/métodos , Achados Incidentais , Doenças Ovarianas/diagnóstico por imagem , Doenças Uterinas/diagnóstico por imagem , Feminino , Humanos , Ovário/diagnóstico por imagem , Útero/diagnóstico por imagem
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