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1.
Curr Opin Ophthalmol ; 31(3): 199-206, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32168003

RESUMO

PURPOSE OF REVIEW: This article reviews emerging technologies in retinal imaging, including their scientific background, clinical implications and future directions. RECENT FINDINGS: Fluorescence lifetime imaging ophthalmoscopy is a technology that will reveal biochemical and metabolic changes of the retina at the cellular level. Optical coherence tomography is evolving exponentially toward higher resolution, faster speed, increased portability and more cost effective. Adaptive optics scanning laser ophthalmoscopy fluorescein angiography will provide unprecedented detail of the retinal vasculature down to the level of capillaries, enabling earlier and more sensitive detection of retinal vascular diseases. SUMMARY: Continued developments in retinal imaging focus on improved resolution, faster speed and noninvasiveness, while providing new information on the structure-function relationship of the retina inclusive of metabolic activity at the cellular level.


Assuntos
Diagnóstico por Imagem/tendências , Doenças Retinianas/diagnóstico por imagem , Vasos Retinianos/diagnóstico por imagem , Angiofluoresceinografia/métodos , Humanos , Oftalmoscopia , Tomografia de Coerência Óptica/métodos
2.
Br J Radiol ; 93(1108): 20190948, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32101448

RESUMO

Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what can be seen in an image, and to turn it into valuable predictive outcomes. As a result of advances in both computational hardware and machine learning algorithms, computers are making great strides in obtaining quantitative information from imaging and correlating it with outcomes. Radiomics, in its two forms "handcrafted and deep," is an emerging field that translates medical images into quantitative data to yield biological information and enable radiologic phenotypic profiling for diagnosis, theragnosis, decision support, and monitoring. Handcrafted radiomics is a multistage process in which features based on shape, pixel intensities, and texture are extracted from radiographs. Within this review, we describe the steps: starting with quantitative imaging data, how it can be extracted, how to correlate it with clinical and biological outcomes, resulting in models that can be used to make predictions, such as survival, or for detection and classification used in diagnostics. The application of deep learning, the second arm of radiomics, and its place in the radiomics workflow is discussed, along with its advantages and disadvantages. To better illustrate the technologies being used, we provide real-world clinical applications of radiomics in oncology, showcasing research on the applications of radiomics, as well as covering its limitations and its future direction.


Assuntos
Aprendizado Profundo/tendências , Diagnóstico por Imagem/tendências , Processamento de Imagem Assistida por Computador/tendências , Tecnologia Radiológica/tendências , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias da Mama/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Feminino , Previsões , Humanos , Processamento de Imagem Assistida por Computador/métodos , Neoplasias Pulmonares/diagnóstico por imagem , Masculino , Radiografia/métodos , Tecnologia Radiológica/métodos , Fluxo de Trabalho
5.
Presse Med ; 48(10): 1101-1111, 2019 Oct.
Artigo em Francês | MEDLINE | ID: mdl-31676215

RESUMO

Breast cancer imaging is always improving for the last 20 years in spite of digitalization and computer development. News tools in mammography (Digital Breast Tomosynthesis, Contrast enhanced mammography), sonography (elastography, Automated echography), MRI (Diffusion, abbreviated MRI) and Nuclear medicine has the great potential to be the future of breats imaging. But true revolution will be to use the huge volume of "hidden" imaging data, by Intelligence Artificial process or Biological progress (in genomics, proteiomics) to purpose to our patient a personalized imaging.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Angiografia/métodos , Inteligência Artificial/tendências , Neoplasias da Mama/irrigação sanguínea , Meios de Contraste , Diagnóstico por Imagem/tendências , Técnicas de Imagem por Elasticidade/métodos , Feminino , Genômica , Humanos , Imagem por Ressonância Magnética/métodos , Mamografia/métodos , Mamografia/tendências , Tomografia por Emissão de Pósitrons/métodos , Proteômica , Linfonodo Sentinela/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia Doppler em Cores , Ultrassonografia Mamária/métodos
6.
Med Sci (Paris) ; 35(8-9): 682-688, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31532381

RESUMO

Multi-elemental imaging of soft tissues using Laser-induced breakdown spectroscopy, also known as LIBS, allows for the direct visualization of the distribution of endogenous or exogenous elements within tissues. LIBS was used to image the kinetics of metal nanoparticles in elimination organs, but also the physiological distribution of biological elements in situ and the topography of chemicals or metals in exposed human tissues. Based on our experience and recent literature in the field of imaging the elemental content of animal and human specimens, this review describes the principle and characteristics of the instrument, technical considerations for setting up experiments with LIBS, its advantages, limitations and possibilities for pre-clinical and medical applications.


Assuntos
Diagnóstico por Imagem/tendências , Lasers , Análise Espectral/métodos , Alumínio/efeitos adversos , Alumínio/química , Animais , Diagnóstico por Imagem/métodos , Hipersensibilidade a Drogas/etiologia , Estudos de Avaliação como Assunto , Humanos
7.
Br J Radiol ; 92(1103): 20180309, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31502858

RESUMO

Atherosclerosis is a chronic immunomodulated disease that affects multiple vascular beds and results in a significant worldwide disease burden. Conventional imaging modalities focus on the morphological features of atherosclerotic disease such as the degree of stenosis caused by a lesion. Modern CT, MR and positron emission tomography scanners have seen significant improvements in the rapidity of image acquisition and spatial resolution. This has increased the scope for the clinical application of these modalities. Multimodality imaging can improve cardiovascular risk prediction by informing on the constituency and metabolic processes within the vessel wall. Specific disease processes can be targeted using novel biological tracers and "smart" contrast agents. These approaches have the potential to inform clinicians of the metabolic state of atherosclerotic plaque. This review will provide an overview of current imaging techniques for the imaging of atherosclerosis and how various modalities can provide information that enhances the depiction of basic morphology.


Assuntos
Aterosclerose/diagnóstico , Diagnóstico por Imagem/tendências , Doenças da Aorta/diagnóstico , Doenças das Artérias Carótidas/diagnóstico , Meios de Contraste , Doença das Coronárias/diagnóstico , Humanos , Angiografia por Ressonância Magnética/tendências , Espectroscopia de Ressonância Magnética , Nanopartículas de Magnetita , Imagem Molecular/tendências , Espectrofotometria Infravermelho/tendências , Tomografia de Coerência Óptica/tendências , Tomografia Computadorizada por Raios X/tendências , Ultrassonografia de Intervenção/tendências , Calcificação Vascular/diagnóstico
8.
JAMA ; 322(9): 843-856, 2019 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-31479136

RESUMO

Importance: Medical imaging increased rapidly from 2000 to 2006, but trends in recent years have not been analyzed. Objective: To evaluate recent trends in medical imaging. Design, Setting, and Participants: Retrospective cohort study of patterns of medical imaging between 2000 and 2016 among 16 million to 21 million patients enrolled annually in 7 US integrated and mixed-model insurance health care systems and for individuals receiving care in Ontario, Canada. Exposures: Calendar year and country (United States vs Canada). Main Outcomes and Measures: Use of computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, and nuclear medicine imaging. Annual and relative imaging rates by imaging modality, country, and age (children [<18 years], adults [18-64 years], and older adults [≥65 years]). Results: Overall, 135 774 532 imaging examinations were included; 5 439 874 (4%) in children, 89 635 312 (66%) in adults, and 40 699 346 (30%) in older adults. Among adults and older adults, imaging rates were significantly higher in 2016 vs 2000 for all imaging modalities other than nuclear medicine. For example, among older adults, CT imaging rates were 428 per 1000 person-years in 2016 vs 204 per 1000 in 2000 in US health care systems and 409 per 1000 vs 161 per 1000 in Ontario; for MRI, 139 per 1000 vs 62 per 1000 in the United States and 89 per 1000 vs 13 per 1000 in Ontario; and for ultrasound, 495 per 1000 vs 324 per 1000 in the United States and 580 per 1000 vs 332 per 1000 in Ontario. Annual growth in imaging rates among US adults and older adults slowed over time for CT (from an 11.6% annual percentage increase among adults and 9.5% among older adults in 2000-2006 to 3.7% among adults in 2013-2016 and 5.2% among older adults in 2014-2016) and for MRI (from 11.4% in 2000-2004 in adults and 11.3% in 2000-2005 in older adults to 1.3% in 2007-2016 in adults and 2.2% in 2005-2016 in older adults). Patterns in Ontario were similar. Among children, annual growth for CT stabilized or declined (United States: from 10.1% in 2000-2005 to 0.8% in 2013-2016; Ontario: from 3.3% in 2000-2006 to -5.3% in 2006-2016), but patterns for MRI were similar to adults. Changes in annual growth in ultrasound were smaller among adults and children in the United States and Ontario compared with CT and MRI. Nuclear medicine imaging declined in adults and children after 2006. Conclusions and Relevance: From 2000 to 2016 in 7 US integrated and mixed-model health care systems and in Ontario, rates of CT and MRI use continued to increase among adults, but at a slower pace in more recent years. In children, imaging rates continued to increase except for CT, which stabilized or declined in more recent periods. Whether the observed imaging utilization was appropriate or was associated with improved patient outcomes is unknown.


Assuntos
Diagnóstico por Imagem/tendências , Abdome/diagnóstico por imagem , Adolescente , Adulto , Idoso , Criança , Diagnóstico por Imagem/estatística & dados numéricos , Cabeça/diagnóstico por imagem , Humanos , Imagem por Ressonância Magnética/estatística & dados numéricos , Imagem por Ressonância Magnética/tendências , Pessoa de Meia-Idade , Ontário , Cintilografia/estatística & dados numéricos , Cintilografia/tendências , Coluna Vertebral/diagnóstico por imagem , Tórax/diagnóstico por imagem , Tomografia Computadorizada por Raios X/estatística & dados numéricos , Tomografia Computadorizada por Raios X/tendências , Ultrassonografia/estatística & dados numéricos , Ultrassonografia/tendências , Estados Unidos , Adulto Jovem
9.
Vet Clin North Am Exot Anim Pract ; 22(3): 397-417, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31395322

RESUMO

Diagnostic imaging relies on interpretation of interactions between the body tissue and various energies, such as x-rays, ultrasound, and magnetic or nuclear energies, to differentiate normal from abnormal tissues. Major technological improvements regarding emission and detection of the energetic waves, as well as reconstruction and interpretation of the images, have occurred. These advances made possible visualization of smaller structures, quantitative evaluation of functional processes, and development of unique imaging-guided procedures. This article reviews the technological advances that allowed development of cone beam computed tomography, dual-energy x-ray absorptiometry, and contrast-enhanced ultrasonography, which all could have applications in exotic pet medicine.


Assuntos
Animais Exóticos , Diagnóstico por Imagem/veterinária , Medicina Veterinária/tendências , Absorciometria de Fóton/instrumentação , Absorciometria de Fóton/métodos , Absorciometria de Fóton/tendências , Absorciometria de Fóton/veterinária , Animais , Tomografia Computadorizada de Feixe Cônico/instrumentação , Tomografia Computadorizada de Feixe Cônico/métodos , Tomografia Computadorizada de Feixe Cônico/tendências , Tomografia Computadorizada de Feixe Cônico/veterinária , Diagnóstico por Imagem/instrumentação , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/tendências , Humanos , Ultrassonografia/instrumentação , Ultrassonografia/métodos , Ultrassonografia/tendências , Ultrassonografia/veterinária , Medicina Veterinária/instrumentação , Medicina Veterinária/métodos
10.
Chin Med Sci J ; 34(2): 71-75, 2019 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-31315746

RESUMO

Medical imaging is now being reshaped by artificial intelligence (AI) and progressing rapidly toward future. In this article, we review the recent progress of AI-enabled medical imaging. Firstly, we briefly review the background about AI in its way of evolution. Then, we discuss the recent successes of AI in different medical imaging tasks, especially in image segmentation, registration, detection and recognition. Also, we illustrate several representative applications of AI-enabled medical imaging to show its advantage in real scenario, which includes lung nodule in chest CT, neuroimaging, mammography, and etc. Finally, we report the way of human-machine interaction. We believe that, in the future, AI will not only change the traditional way of medical imaging, but also improve the clinical routines of medical care and enable many aspects of the medical society.


Assuntos
Inteligência Artificial , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/tendências , Algoritmos , Humanos
11.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 54(7): 492-497, 2019 Jul 09.
Artigo em Chinês | MEDLINE | ID: mdl-31288331

RESUMO

The development of computer hardware allows rapid accumulation of medical imaging data. Deep learning has shown great potential in medical imaging data analysis and establish a new area of machine learning. The commonly used deep learning models were firstly introduced in the paper, and then, summarized with the application of deep learning in the detection, classification, diagnosis, segmentation, identification of medical imaging. The application of deep learning in oral and maxillofacial radiology and other discipline of stomatology was proposed. At the end, the paper discussed the problems of deep learning in medical imaging research.


Assuntos
Aprendizado Profundo , Diagnóstico por Imagem , Pesquisa , Diagnóstico por Imagem/tendências , Aprendizado de Máquina , Pesquisa/tendências
12.
Best Pract Res Clin Endocrinol Metab ; 33(2): 101278, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-31208872

RESUMO

Decision-making in pituitary disease is critically dependent on high quality imaging of the sella and parasellar region. Magnetic resonance imaging (MRI) is the investigation of choice and, for the majority of patients, combined T1 and T2 weighted sequences provide the information required to allow surgery, radiotherapy (RT) and/or medical therapy to be planned and long-term outcomes to be monitored. However, in some cases standard clinical MR sequences are indeterminate and additional information is needed to help inform the choice of therapy for a pituitary adenoma (PA). This article reviews current recommendations for imaging of PA, examines the potential added value that alternative MR sequences and/or CT can offer, and considers how the use of functional/molecular imaging might allow definitive treatment to be recommended for a subset of patients who would otherwise be deemed unsuitable for (further) surgery and/or RT.


Assuntos
Adenoma/diagnóstico , Diagnóstico por Imagem/tendências , Neoplasias Hipofisárias/diagnóstico , Adenoma/patologia , Adenoma/terapia , Diagnóstico Diferencial , Diagnóstico por Imagem/métodos , Humanos , Imagem por Ressonância Magnética/métodos , Neuroimagem/métodos , Neuroimagem/tendências , Doenças da Hipófise/diagnóstico , Neoplasias Hipofisárias/patologia , Neoplasias Hipofisárias/terapia
14.
PLoS Biol ; 17(6): e3000340, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31216269

RESUMO

Forums and email lists play a major role in assisting scientists in using software. Previously, each open-source bioimaging software package had its own distinct forum or email list. Although each provided access to experts from various software teams, this fragmentation resulted in many scientists not knowing where to begin with their projects. Thus, the scientific imaging community lacked a central platform where solutions could be discussed in an open, software-independent manner. In response, we introduce the Scientific Community Image Forum, where users can pose software-related questions about digital image analysis, acquisition, and data management.


Assuntos
Diagnóstico por Imagem/tendências , Disseminação de Informação/métodos , Correio Eletrônico , Humanos , Processamento de Imagem Assistida por Computador , Internet , Software , Inquéritos e Questionários
16.
J Immunol Res ; 2019: 5474519, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31143781

RESUMO

Detection and analysis of antigen-antibody reaction is one of the most critical detection techniques in the fields of medicine, biology, environmental science, and food safety. Traditional and classical methods for detecting antigen and antibody encounter many problems, such as time-consuming, high cost, and low accuracy. A novel immune microsphere imaging technique by the microlens is used to test the changes of refractive index before and after antigen-antibody reaction. It can quickly perform qualitative and quantitative determination for antigen-antibody reaction without any labeling, premodification, postwashing, and expensive enzymes. Here, we feature and discuss its principle and advantages, structure of a microlens immunoassay instrument, and potential in measuring clinical samples. It is promising to be developed for application to diagnosis of clinical diseases.


Assuntos
Reações Antígeno-Anticorpo , Imunoensaio/instrumentação , Refratometria/métodos , Anticorpos/metabolismo , Antígenos/metabolismo , Diagnóstico por Imagem/tendências , Humanos , Microesferas
17.
Rheum Dis Clin North Am ; 45(2): 291-302, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30952399

RESUMO

This article outlines the current state of imaging software with an emphasis on mobile sharing of images and mobile sharing of imaged data. The second portion focuses on the mobility of imaging design devices, highlighting the accessibility and the wider application of mobile devices.


Assuntos
Diagnóstico por Imagem , Processamento de Imagem Assistida por Computador , Radiologia , Software , Inteligência Artificial , Diagnóstico por Imagem/instrumentação , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/tendências , Humanos , Radiologia/métodos , Radiologia/tendências
18.
Pharm Res ; 36(6): 78, 2019 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-30945009

RESUMO

This review article presents the state-of-the-art in the major imaging modalities supplying relevant information on patient health by real-time monitoring to establish an accurate diagnosis and potential treatment plan. We draw a comprehensive comparison between all imagers and ultimately end with our focus on two main types of scanners: X-ray CT and MRI scanners. Numerous types of imaging probes for both imaging techniques are described, as well as reviewing their strengths and limitations, thereby showing the current need for the development of new diagnostic contrast agents (CAs). The role of nanoparticles in the design of CAs is then extensively detailed, reviewed and discussed. We show how nanoparticulate agents should be promising alternatives to molecular ones and how they are already paving new routes in the field of nanomedicine.


Assuntos
Meios de Contraste , Diagnóstico por Imagem/métodos , Diagnóstico por Imagem/tendências , Nanomedicina/métodos , Animais , Meios de Contraste/efeitos adversos , Meios de Contraste/química , Diagnóstico por Imagem/instrumentação , Sistemas de Liberação de Medicamentos , Humanos , Estrutura Molecular , Nanomedicina/tendências , Nanopartículas/efeitos adversos , Nanopartículas/química , Tamanho da Partícula , Polímeros/química , Propriedades de Superfície
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