Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 12.072
Filtrar
1.
Praxis (Bern 1994) ; 109(1): 31-34, 2020 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-31910767

RESUMO

CoLaus: Diet, the Forgotten Key to Preventing Cardiovascular Diseases Abstract. Healthy eating is paramount for the prevention and management of cardiovascular diseases. Still, data from the CoLaus study show that dietary management of cardiovascular risk factors and cardiovascular disease is little implemented. Less than one fifth of participants with dyslipidemia reported being on a hypolipidemic diet, and only half of participants with diabetes reported being on an antidiabetic diet. Further, the occurrence of a myocardial infarction was not associated with an improvement in dietary quality.


Assuntos
Doenças Cardiovasculares , Diabetes Mellitus , Dieta , Dislipidemias , Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus/prevenção & controle , Dislipidemias/prevenção & controle , Humanos
2.
Angiology ; 71(1): 10-16, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-30966756

RESUMO

Cardiovascular disease (CVD) remains the major cause of death and disability worldwide, and residual risk after implementing all current therapies is still high. In this context, the latest (2016) European Cardiology Society/European Atherosclerosis Society guidelines recommend that triglyceride (TG)-lowering drugs should be used in high-risk patients with TGs levels >2.3 mmol/L (200 mg/dL), after lifestyle measures fail to lower them. After several neutral CVD outcome trials with n-3 fatty acids, the Reduction of Cardiovascular Events with EPA-Intervention Trial met its primary end point, that is, among patients with elevated TGs levels despite the use of statins, the risk of ischemic events, including cardiovascular death, was significantly lower in those who received 4 g of icosapent ethyl daily. In this review, we comment on the findings of previous and recently published randomized controlled CVD outcome trials assessing n-3 fatty acids supplementation. Both efficacy and safety, as well as future perspectives, are discussed.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Suplementos Nutricionais , Dislipidemias/tratamento farmacológico , Ácido Eicosapentaenoico/análogos & derivados , Ácidos Graxos Insaturados/uso terapêutico , Lipídeos/sangue , Biomarcadores/sangue , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/epidemiologia , Suplementos Nutricionais/efeitos adversos , Dislipidemias/sangue , Dislipidemias/epidemiologia , Ácido Eicosapentaenoico/efeitos adversos , Ácido Eicosapentaenoico/uso terapêutico , Ácidos Graxos Insaturados/efeitos adversos , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Risco , Resultado do Tratamento
3.
Arch Oral Biol ; 109: 104553, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31563004

RESUMO

This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD). METHODS: Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2). RESULTS: Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p < 0.001). In all rats the ligated teeth showed a greater bone loss as compared with the unligated molars. At the end of the experiment the AT + L was the worst in % lower bone volume (p < 0.01), hPDL and PBS (p < 0.05). In contrast, rats fed n-3PUFA + L was similar to those rats fed C diet (p > 0.05). CONCLUSION: Alveolar bone and dyslipidemia improved by substituting saturated fat intake for a n-3PUFA rich diet, in hypercholesterolemic rats with PD.


Assuntos
Perda do Osso Alveolar/terapia , Dieta , Ácidos Graxos Ômega-3/administração & dosagem , Óleos de Peixe/administração & dosagem , Hipercolesterolemia/fisiopatologia , Periodontite/fisiopatologia , Animais , Dislipidemias/terapia , Distribuição Aleatória , Ratos , Ratos Wistar
4.
Zhonghua Nei Ke Za Zhi ; 59(1): 18-22, 2020 Jan 01.
Artigo em Chinês | MEDLINE | ID: mdl-31887831

RESUMO

The prevalence of dyslipidemia in Chinese adult is increasing dramatically, which poses a severe challenge to the prevention and treatment of atherosclerotic cardiovascular diseases. In recent years, a series of new research results have been published, providing a lot of new information for the management strategy of dyslipidemia. In order to apply these new research results to clinical practice for the further prevention and treatment of dyslipidemia more reasonably and effectively, the China Cholesterol Education Program (CCEP) Working Committee organized joint expert meeting and revised the "Expert Advice on Prevention and Treatment of Dyslipidemia in China Cholesterol Education Program 2014", in which a new classification standard for cardiovascular risk stratification has been proposed, and the target value of lipid-lowering therapy has been updated.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Colesterol/sangue , Dislipidemias , Guias de Prática Clínica como Assunto , Adulto , China , Dislipidemias/prevenção & controle , Dislipidemias/terapia , Humanos , Fatores de Risco
5.
Angiology ; 71(1): 17-26, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31129986

RESUMO

The Middle East and North Africa (MENA) region has a high burden of morbidity and mortality due to premature (≤55 years in men; ≤65 years in women) myocardial infarction (MI) and acute coronary syndrome (ACS). Despite this, the prevalence of risk factors in patients presenting with premature MI or ACS is incompletely described. We compared lifestyle, clinical risk factors, and biomarkers associated with premature MI/ACS in the MENA region with selected non-MENA high-income countries. We identified English-language, peer-reviewed publications through PubMed (up to March 2018). We used the World Bank classification system to categorize countries. Patients with premature MI/ACS in the MENA region had a higher prevalence of smoking than older patients with MI/ACS but a lower prevalence of diabetes, hypertension, and dyslipidemia. Men with premature MI/ACS had a higher prevalence of smoking than women but a lower prevalence of diabetes and hypertension. The MENA region had sparse data on lifestyle, diet, psychological stress, and physical activity. To address these knowledge gaps, we initiated the ongoing Gulf Population Risks and Epidemiology of Vascular Events and Treatment (Gulf PREVENT) case-control study to improve primary and secondary prevention of premature MI in the United Arab Emirates, a high-income country in the MENA region.


Assuntos
Síndrome Coronariana Aguda/epidemiologia , Infarto do Miocárdio/epidemiologia , Síndrome Coronariana Aguda/mortalidade , Síndrome Coronariana Aguda/prevenção & controle , África do Norte/epidemiologia , Idade de Início , Idoso , Estudos de Casos e Controles , Comorbidade , Diabetes Mellitus/epidemiologia , Dislipidemias/epidemiologia , Feminino , Humanos , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Oriente Médio/epidemiologia , Mortalidade Prematura , Infarto do Miocárdio/mortalidade , Infarto do Miocárdio/prevenção & controle , Prevalência , Prevenção Primária , Prognóstico , Projetos de Pesquisa , Fatores de Risco , Prevenção Secundária , Fatores Sexuais , Fumar/efeitos adversos , Fumar/epidemiologia
6.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 44(10): 1128-1136, 2019 Oct 28.
Artigo em Chinês | MEDLINE | ID: mdl-31857506

RESUMO

OBJECTIVE: To examine the efficacy and safety for metformin in treating antipsychotic-induced dyslipidemia.
 Methods: Two randomized placebo-controlled trials were included in the analysis. A total of 201 schizophrenia patients with dyslipidemia after treatment with an antipsychotic were collected, and the patients were divided into two groups: a 1 000 mg/d metformin group (n=103) and a placebo group (n=98). The clinical symptoms and metabolic indicators such as body weight, blood glucose, and blood lipids were assessed at baseline, the 12th week and the 24th week after treatment respectively.
 Results: After metformin treatment, the mean difference in the low-density lipoprotein cholesterol (LDL-C) value between the metformin group and the placebo group was from 0.16 mmol/L at baseline to -0.86 mmol/L at the end of the 24th week, which was decreased by 1.02 mmol/L (P<0.01). At the 24th week, the LDL-C was more than 3.37 mmol/L in 25.3% patients in the metformin group, which was significantly lower than that in the placebo group (64.8%) (P<0.01). Compared with the placebo group, there were significant changes in the weight, body mass index (BMI), insulin, insulin resistance index, total cholesterol and triglyceride, and high-density lipoprotein cholesterol (HDL-C) in the metformin group (all P<0.05). The treatment effects on weight and insulin resistance appeared at the 12th week and further improved at the 24th week, but the effects on improving dyslipidemia only significantly occurred at the end of the 24th week.
 Conclusion: The metformin treatment is effective in improving antipsychotic-induced dyslipidemia and insulin resistance, and the effect to reduce the antipsychotic-induced insulin resistance appears earlier than the effect to improve dyslipidemia.


Assuntos
Antipsicóticos/efeitos adversos , Diabetes Mellitus Tipo 2 , Dislipidemias , Metformina/uso terapêutico , Glicemia , Método Duplo-Cego , Dislipidemias/induzido quimicamente , Dislipidemias/tratamento farmacológico , Humanos , Hipoglicemiantes
7.
Wiad Lek ; 72(11 cz 2): 2210-2213, 2019.
Artigo em Polonês | MEDLINE | ID: mdl-31860838

RESUMO

Cardiovascular disease is the leading cause of death among patients with chronic kidney disease (CKD). Primary and secondary prevention of cardiovascular events is one of the major CKD patients' treatment targets. Dyslipidaemia is the important modifiable risk factor in general population. Each 1.0 mmol reduction in LDL cholesterol with statins reduces annual rate of heart attack, coronary revascularization or ischemic stroke by 20% leading to 10% reduction of all-cause mortality. Adding ezetimibe, an inhibitor of intestinal lipids absorption, further reduces LDL cholesterol by 20%. Optimal lipid lowering treatment for CKD patients remains unclear. Cardiovascular risk reduction observed with statins therapy decreases together with a progression of the disease, moreover patients with advanced CKD treated with high doses of statins have an increased risk of adverse events. These patients might benefit from adding ezetimibe to moderate dose statin therapy for prevention of cardiovascular events.


Assuntos
Dislipidemias , Ezetimiba/uso terapêutico , Insuficiência Renal Crônica , Doenças Cardiovasculares , LDL-Colesterol , Dislipidemias/tratamento farmacológico , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases
8.
Rev. cuba. angiol. cir. vasc ; 20(2): e386, jul.-dic. 2019. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1003856

RESUMO

Introducción: Los accidentes cerebrovasculares constituyen un problema de salud mundial con tendencia creciente; en la actualidad es la tercera causa de muerte. Objetivo: Describir la efectividad y durabilidad de la endarterectomía carotidea a largo plazo en la enfermedad carotidea extracraneal. Métodos: Se realizó un estudio descriptivo, ambispectivo en 44 pacientes sometidos a un total de 52 endarterectomías carotideas realizadas en el servicio de Angiología y Cirugía Vascular del Hospital Docente Clínico Quirúrgico Hermanos Ameijeiras. A todos se les realizó un seguimiento clínico con ultrasonografía doppler. El período de tiempo analizado fue de ocho años. Se tuvo en cuenta las variables: sexo, edad, factores de riesgo asociados, categoría clínica, localización topográfica de las lesiones, complicaciones tardías, tiempo de permeabilidad y resultados posquirúrgicos. Resultados: Predominó el sexo masculino (68,2 por ciento). Las lesiones carotideas asintomáticas y sintomáticas representaron el 50 por ciento respectivamente. El hábito de fumar y la dislipidemia fueron los factores de riesgo más frecuentes. Hubo predominio de las complicaciones tardías (55,8 por ciento) con relevancia de la restenosis carotidea (n= 21). El tiempo promedio de permeabilidad primaria del sector revascularizado fue de cinco años. El 86,5 por ciento de los pacientes seguidos a largo plazo mostraron resultados posquirúrgicos satisfactorios al no presentar eventos neurológicos isquémicos o lesiones carotideas con repercusión hemodinámica. Conclusiones: La endarterectomía carotidea es un procedimiento seguro con baja morbilidad y mortalidad perioperatorias que garantiza una reducción significativa en las tasas de enfermedad cerebrovascular isquémica en el seguimiento a largo plazo con baja incidencia de complicaciones vasculares y neurológicas tardías(AU)


Introduction: Cardiovascular events constitute a global health problem with a growing tendency. Nowadays, they represent the third cause of death. Objective: To describe the effectiveness and durability of long-term carotid endarterectomy in the extracranial carotid disease. Methods: A descriptive, ambispective study was conducted in 44 patients subjected to 52 carotid endarterectomies that were performed in the service of Angiology and Vascular Surgery of Hermanos Ameijeiras Teaching-Clinical- Surgical Hospital. A clinical follow-up was performed with Doppler ultrasonography to all the patients. The period analyzed was eight years. The variables considered were: sex, age, associated risk factors, clinical category, topographical localization of the lesions, late complications, time of permeability and postsurgical results. Results: Male sex predominated (68,2 percent). Asymptomatic and symptomatic carotid lesions represented 50 percent respectively. The smoking habit and dyslipidemia were the most common risk factors. There was predominance of late complications (55,8 percent) being notable the carotid restenosis (n = 21). The average time of primary permeability of the revascularized sector was five years. 86,5 percent of the patients followed in the long term showed satisfactory postsurgical results by not presenting ischemic neurological events or carotid lesions with hemodynamic impact. Conclusions: Carotid endarterectomy is a safe procedure with low morbidity and peri-operative mortality that ensures a significant reduction in ischemic cerebrovascular disease´s rates in long-term follow-up with low incidence of late vascular and neurological complications(AU)


Assuntos
Humanos , Masculino , Feminino , Fatores de Risco , Endarterectomia das Carótidas/métodos , Traumatismo Cerebrovascular/cirurgia , Dislipidemias/prevenção & controle
9.
Wei Sheng Yan Jiu ; 48(6): 945-952, 2019 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-31875820

RESUMO

OBJECTIVE: To understand the epidemiological characteristics and risk factors of dyslipidemia in adult residents of Jiangsu Province in 2014. METHODS: A total of 8677 permanent residents over 18 years old were selected from 12 monitoring sites in Jiangsu Province in 2014 by multi-stage stratified cluster random sampling and were enrolled for questionnaire survey, physic examination and biochemical tests. RESULTS: Totally, 8299 cases were analyzed including 3732 males(45. 0%) and 4567 females(55. 0%). The rate of dyslipidemia was 38. 2%(standardized prevalence rate was38. 5%). Among the 8299 cases, 25. 8% had high TG(standardized rate was 25. 9%), 13. 2% had low HDL-C(standardized rate was 13. 4%), 6. 0% had high TC(standardized rate was 5. 9%). With the increase of age, the prevalence of dyslipidemia in males showed a downward trend(P<0. 05), and the dyslipidemia in females showed an increasing trend(P<0. 05). The prevalence of dyslipidemia in urban and rural adults was42. 9% and 36. 9%. The Logistic multivariate analysis showed that heavy physical and other types of labor were protective factors for dyslipidemia(OR = 0. 422 and 0. 749). Primary school education or above, occupational labor of medium type, overweight and obesity, central obesity were risk factors for dyslipidemia. Hypertension, diabetes, stroke were positively correlated with dyslipidemia(OR = 1. 045, 1. 927, 1. 927 and 1. 501). CONCLUSION: The prevalence of dyslipidemia in adults in Jiangsu Province is on the rise. Hyperlipidemia and low HDL-C are the main forms of dyslipidemia in Jiangsu Province.


Assuntos
Diabetes Mellitus , Dislipidemias , Adolescente , Adulto , China , Feminino , Humanos , Masculino , Obesidade , Sobrepeso , Prevalência , Fatores de Risco , Adulto Jovem
10.
Zhonghua Nei Ke Za Zhi ; 58(10): 751-757, 2019 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-31594173

RESUMO

Objective: To investigate the characteristics of body composition (BC) in gout patients and its clinical significance. Methods: Consecutive gout patients were recruited between August 2017 and December 2018. Demographic information, clinical characteristics and comorbidities were collected. BC was assessed by bioelectric impedance analysis including body fat percentage (BF%), trunk and limb BF%, appendicular skeletal muscle index. Overfat was defined by BF% ≥25% for male and ≥35% for female. The association between BC and serum uric acid (sUA) was evaluated by multiple linear regression. Results: A total of 362 gout patients were recruited with median age 38 (30, 52) years, 96.1% (348/362) were male. Mean sUA was (551±133) µmol/L. The mean BF% was (25.8±6.4)% with 53.6%(194/362) patients overfat. Male gout patients with overfat showed more affected joints [4(2, 6) vs. 2(2, 5)], higher sUA [(576±126)µmol/L vs. (523±134) µmol/L], higher prevalence of dyslipidemia [70.1%(131/187) vs. 54.0%(87/161)], metabolic syndrome [60.8%(118/187) vs. 28.0%(47/161)], fatty liver [58.2%(113/187) vs. 35.1%(59/161)] and hypertension [44.4%(83/187) vs. 25.5%(41/161)] than male patients with normal fat (all P<0.05). Their BF%, trunk BF% and limb BF% were positively correlated with the numbers of affected joints, sUA, metabolic syndrome, fatty liver, and hypertension, respectively (r=0.154-0.435, all P<0.05). Multivariable linear regression suggested that BF% (ß=4.29, P=0.020) and trunk BF% (ß=9.11, P=0.007), but not limb BF%, were positively correlated with sUA. Conclusion: Overfat is very common in gout patients. The proportion of trunk fat in male patients is positively correlated with sUA. When assessing obesity in gout patients clinically, body composition analysis should be performed simultaneously.


Assuntos
Composição Corporal/fisiologia , Gota/diagnóstico , Obesidade/epidemiologia , Ácido Úrico/sangue , Adulto , Dislipidemias/epidemiologia , Feminino , Gota/sangue , Gota/epidemiologia , Humanos , Hipertensão/sangue , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Hepatopatia Gordurosa não Alcoólica/sangue , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Obesidade/sangue , Prevalência
11.
Medicine (Baltimore) ; 98(40): e17153, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577706

RESUMO

The present study evaluated the association between appendectomy and rheumatoid arthritis (RA) using a national sample cohort of the Korean population. In this cohort study, the Korean National Health Insurance Service-National Sample Cohort of individuals ≥20 years old was collected from 2002 to 2013. A total of 14,995 appendectomy participants were 1:4 matched with 59,980 control subjects for age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed the occurrence of RA in both the appendectomy and control groups. Appendectomies were identified using operation codes for appendicitis only. RA was defined by International Classification of Disease-10 codes (M05 or M06) and medication histories. Crude and adjusted hazard ratios (HRs) were analyzed using a stratified Cox proportional hazard model. Subgroup analyses were performed on groups stratified by age and sex. The adjusted HR for RA was 1.02 (95% confidence interval = 0.76-1.38) in the appendectomy group (P = .883). In all of the subgroup analyses according to age and sex, the adjusted HRs for RA were not higher in the appendectomy group than those in the control group. We could not identify any significant relationship between appendectomy and RA.


Assuntos
Apendicectomia/estatística & dados numéricos , Apendicite/cirurgia , Artrite Reumatoide/epidemiologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Depressão/epidemiologia , Dislipidemias/epidemiologia , Feminino , Seguimentos , Humanos , Hipertensão/epidemiologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Características de Residência , Fatores de Risco , Fatores Sexuais , Fatores Socioeconômicos , Adulto Jovem
12.
Arq Gastroenterol ; 56(3): 270-275, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31633724

RESUMO

BACKGROUND: Metabolic risk factors of non alcoholic fatty liver disease (NAFLD) in non diabetic teetotallers who constitute a definite group are not well defined. OBJECTIVE: To identify the metabolic risk factors of NAFLD if any in non diabetic subjects who do not consume alcohol. METHODS: In a cross sectional study the effect of metabolic parameters (BMI, individual lipid levels, hemoglobinA1c (HbA1c), HOMA IR and the metabolic syndrome components) of 150 consecutive non diabetic teetotallers (90 with normal glucose tolerance and 60 prediabetics) on their NFS (quantifiable severity parameter of NAFLD) was studied by linear regression analysis. Similar study was done in the normal glucose tolerance and prediabetes groups separately. These parameters were then compared with those of 75 matched diabetic teetotallers with NAFLD. To analyse further the difference between normal glucose tolerance, prediabetic and overt diabetic groups, binary logistic regression of the factors was carried out taking prediabetes and diabetes as outcome variable. RESULTS: All the metabolic parameters were significantly higher in diabetics compared to non diabetics and in prediabetics compared to those with normal glucose tolerance except high-density lipoprotein cholesterol. Triglyceride, high-density lipoprotein cholesterol and BMI significantly predicted NFS in the overall (adjusted R2 68.7%, P=0.000) and normal glucose tolerance groups (adjusted R2 73.2%, P=0.000) whereas BMI, triglyceride, low-density lipoprotein cholesterol and HbA1c did in prediabetics (adjusted R2 89%, P=0.000). The metabolic syndrome was significantly associated with NFS in the overall and prediabetic groups. High triglyceride (odds ratio1.08), low-density lipoprotein cholesterol (odds ratio1.03) and HbA1c (odds ratio 11.54) were positively associated with prediabetes compared to normal glucose tolerance group. CONCLUSION: In nondiabetic teetotallers dyslipidemias are the prime contributors to the development of NAFLD.


Assuntos
Dislipidemias/metabolismo , Resistência à Insulina/fisiologia , Hepatopatia Gordurosa não Alcoólica/metabolismo , Adulto , Idoso , Índice de Massa Corporal , Estudos Transversais , Diabetes Mellitus Tipo 2/metabolismo , Dislipidemias/sangue , Feminino , Hemoglobina A Glicada/análise , Humanos , Masculino , Síndrome Metabólica/metabolismo , Pessoa de Meia-Idade , Hepatopatia Gordurosa não Alcoólica/etiologia , Obesidade/metabolismo , Fatores de Risco , Triglicerídeos/sangue
13.
J Assoc Physicians India ; 67(7): 26-29, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31559764

RESUMO

Background: Although less common, insulin resistance and deranged lipids are also observed in normal weight individuals. Few studies have assessed body composition and lipid profiles in normal weight insulin resistant individuals. Objective: To assess differences in body composition and lipid profile in normal weight and overweight 40-60 years apparently healthy men with special reference to insulin resistance. Design: Cross-sectional observational study in apparently healthy men (40-60 yrs) was performed. Anthropometry, body composition (Dual Energy X-ray Absorptiometry scan), biochemical parameters (lipids, sugar and Insulin) were assessed. HOMA_IR was calculated. Subjects were grouped based on BMI and HOMA-IR for comparison. Results: Of the 286 subjects 152 (53%) had BMI < 25 (group A) and 134 (47%) had BMI > 25 (group B). Homa-IR was more than 3 in 18% in and in 36% in B. Group B had significantly higher fat, waist circumference, systolic blood pressure, insulin and HOMA-IR. In subgroup analysis in group A, subjects with HOMA IR>3 (group A2) had significantly higher BMI, waist, TG, TG: HDL ratio, android and total fat and lower HDL as compared sub-group A1(HOMA IR<3) (p< 0.05). Mean BMI, waist circumference and systolic blood pressure were significantly higher in B2 than A2 group (p< 0.05). Although total, android and gynoid fat percentage were significantly higher in group B2, android to gynoid ratio was significantly higher in A2 (p< 0.05). Conclusion: No significant difference in lipids and fat distribution between insulin resistant and non-resistant subjects in overweight groups suggests that insulin resistance in overweight may be an extension of the pathological state related to obesity. In contrast, significant differences in lipid and fat distribution in normal weight insulin resistant individuals may likely be due to a different mechanism.


Assuntos
Dislipidemias , Resistência à Insulina , Adulto , Índice de Massa Corporal , Estudos Transversais , Humanos , Insulina , Masculino , Pessoa de Meia-Idade , Circunferência da Cintura
14.
J Assoc Physicians India ; 67(7): 30-33, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31559765

RESUMO

Objectives: Individual with diabetes may have several from of Dyslipidemia. Dyslipidemia has been considered to be factor that plays a risk in progression of micro vascular disease, especially in diabetes.1 The present study is intended to Study of correlation between Apolipoprotein B and Dyslipidemia in type 2 diabetes patients and prevalence of dyslipidemia in type 2 diabetic patients. Material and Methods: Prospective cross- sectional study conducted on 100 cases of type 2 diabetes mellitus. Groups are divided according to A/C ratio and association of dyslipidemia was seen. Serum Apolipoprotein B was measured using immunoturbidimetric method. Results: Pearson's correlation analysis of Apo B with lipid parameters in diabetic patients showed that, LDL, TC and Tg were positively correlated with Apo- B. There was a positive and linear correlation between LDL and Tg. Apo- B was negatively correlated with HDL-C. Conclusion: The majority of patients studied had low HDL-C, elevated non HDL- C, elevated total cholesterol, elevated triglycerides, elevated LDL -C and elevated apo B. Apolipoprotein B had a positive linear correlation with total cholesterol, triglycerides, LDL-C, non-HDL-C. The strongest positive correlation was with nonHDL-C. Patients with low HDL-C had high apo B levels.


Assuntos
Apolipoproteínas B/metabolismo , Diabetes Mellitus Tipo 2/epidemiologia , Dislipidemias/epidemiologia , Proteinúria/metabolismo , HDL-Colesterol , Humanos , Estudos Prospectivos , Centros de Atenção Terciária , Triglicerídeos
15.
Wien Klin Wochenschr ; 131(17-18): 395-403, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31493100

RESUMO

BACKGROUND: Liver disease impacts on hepatic synthesis of lipoproteins and lipogenesis but data on dyslipidemia during disease progression are limited. We assessed the patterns of dyslipidemia in (i) different liver disease etiologies and discriminated (ii) non-advanced (non-ACLD) from advanced chronic liver disease (ACLD) as it is unclear how progression to ACLD impacts on dyslipidemia-associated cardiovascular risk. METHODS: Patients with alcoholic liver disease (n = 121), hepatitis C (n = 1438), hepatitis B (n = 384), metabolic/fatty liver disease (n = 532), cholestatic liver disease (n = 119), and autoimmune hepatitis (n = 114) were included. Liver stiffness ≥15 kPa defined ACLD. Dyslipidemia was defined as total cholesterol >200 mg/dL, low-density lipoprotein (LDL)-cholesterol >130 mg/dL and triglycerides >200 mg/dL. RESULTS: Across all etiologies, total cholesterol levels were significantly lower in ACLD, when compared to non-ACLD. Accordingly, LDL-cholesterol levels were significantly lower in ACLD due to hepatitis C, hepatitis B, metabolic/fatty liver disease and autoimmune hepatitis. Triglyceride levels did not differ due to disease severity in any etiology. Despite lower total and LDL cholesterol levels in ACLD, etiology-specific dyslipidemia patterns remained similar to non-ACLD. Contrary to this "improved" lipid status in ACLD, cardiovascular comorbidities were more prevalent in ACLD: arterial hypertension was present in 26.6% of non-ACLD and in 55.4% of ACLD patients (p < 0.001), and diabetes was present in 8.1% of non-ACLD and 25.6% of ACLD patients (p < 0.001). CONCLUSION: Liver disease etiology is a major determinant of dyslipidemia patterns and prevalence. Progression to ACLD "improves" serum lipid levels while arterial hypertension and diabetes mellitus are more prevalent. Future studies should evaluate cardiovascular events after ACLD-induced "improvement" of dyslipidemia.


Assuntos
Dislipidemias , Hepatopatias , Adulto , LDL-Colesterol/sangue , Dislipidemias/epidemiologia , Feminino , Humanos , Hepatopatias/epidemiologia , Hepatopatias/etiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Triglicerídeos/sangue
16.
Biomed Environ Sci ; 32(8): 559-570, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31488232

RESUMO

OBJECTIVE To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015. METHODS Data were collected from three nationally representative cross-sectional surveys. Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination. Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender. RESULTS The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively; by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period. Similar trends in mean non-HDL-c and lipid-related ratios were observed. The weighted dyslipidemia prevalence linearly increased; in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2% (P for trend < 0.001). CONCLUSION Dyslipidemia increased among Chinese adults from 2002 to 2015. Development of a comprehensive strategy to decrease lipid levels in this population is urgently required.


Assuntos
HDL-Colesterol/sangue , LDL-Colesterol/sangue , Dislipidemias/epidemiologia , Triglicerídeos/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Hipercolesterolemia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
17.
Zhonghua Yi Xue Za Zhi ; 99(34): 2665-2669, 2019 Sep 10.
Artigo em Chinês | MEDLINE | ID: mdl-31505716

RESUMO

Objective: To investigate the relationship between insulin resistance (IR) and dyslipidemia in adults with type 1 diabetes (T1DM) and provide more insights on diabetes-related cardiovascular disease management. Methods: A cross-sectional study recruiting patients from Guangdong T1DM Translational Study cohort was conducted between 2011 and 2017. The patients aged ≥18 years, with a diabetes duration of ≥1 year were enrolled in the study. Plasma lipid profile data of eligible patients, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were collected and their relationships with insulin resistance were analyzed. IR in these adults with T1DM was estimated by glucose disposal rate (eGDR) calculated by a model published previously. Patients with eGDR lower than 25 percentiles were grouped as severe IR, otherwise non-severe IR. Results: In total, 499 eligible patients were studied, among which 274 were women (54.9%). The level of eGDR was 8.43 (6.11, 10.63) mg kg(-1) min(-1) and the overall incidence of lipid disorders was 65.3% (326/499) in the study population. The result showed that eGDR was correlated with TC, TG, HDL-C and LDL-C (r=-0.163, -0.303, 0.170 and -0.150, respectively, all P<0.05). After adjusting for gender, age and diabetes duration, eGDR was still associated with TG, TC and LDL-C (all P<0.05). Stepwise multiple linear regression analysis showed that gender (female), elevated TC and declined HDL-C were independent factors associated with the severity of IR (t=5.651, 5.823 and 2.908, respectively, all P<0.05). Conclusions: IR is associated with dyslipidemiain in adults with T1DM. Elevated TC and decreased HDL-C are independent associated factors for insulin resistance.


Assuntos
Diabetes Mellitus Tipo 1 , Dislipidemias , Resistência à Insulina , Adolescente , Adulto , Estudos Transversais , Diabetes Mellitus Tipo 2 , Feminino , Humanos , Masculino , Triglicerídeos
18.
BMC Infect Dis ; 19(1): 820, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31533648

RESUMO

BACKGROUND: The aim of this study was to establish the prevalence of lipodystrophy and its association to cumulative exposure to antiretroviral drugs. METHOD: We conducted a cross sectional study in all HIV- infected patients attending the HIV clinic in the Centre hospitalier universitaire de Montréal (CHUM) with DEXA scan. Lipodystrophy was defined as a trunk/limb fat ratio ≥ 1.5. Association between cumulative exposure to antiretroviral (measured in years of use) with trunk/limb fat ratio (coded as a continuous variable) was assessed using univariate and multivariate linear regression for each antiretroviral drug with at least 40 exposed patients. RESULTS: One hundred sixty-six patients were included. Seventy-five percent were male, median age was 56 years, 67% were Caucasian. Overall, prevalence of lipodystrophy was 47%, with a mean trunk/limb fat ratio of 1.87, SD = 1.03, min = 0.6 and max = 5.87. Each 10-year increase in age and HIV infection duration was associated with an average increase of 0.24 and 0.34 for the trunk/limb fat ratio respectively. (p = 0.003, p = 0.002, respectively) Patients classified as lipodystrophic were more likely to be diabetic (50 vs. 28%, p = 0.07) and to have dyslipidemia (47 vs. 19%, p = 0.01). According to viral load at DEXA test, each one log increase was associated with less probability (0.7) of lipodystrophy. (p = 0.01) Among ARV drugs tested, there was an association between years of use of d4T, ritonavir and raltegravir and higher trunk/limb fat ratio (indicating more lipodystrophy) (p < 0.05). CONCLUSION: Lipodystrophy is very common in HIV infected patients and is correlated with duration of some new antiretroviral drugs.


Assuntos
Antirretrovirais/uso terapêutico , Infecções por HIV/tratamento farmacológico , Síndrome de Lipodistrofia Associada ao HIV/diagnóstico , Absorciometria de Fóton , Adulto , Idoso , Estudos Transversais , Dislipidemias/diagnóstico , Dislipidemias/etiologia , Feminino , Síndrome de Lipodistrofia Associada ao HIV/epidemiologia , Síndrome de Lipodistrofia Associada ao HIV/etiologia , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Carga Viral
19.
Arq. bras. cardiol ; 113(2 supl.1): 158-158, set., 2019.
Artigo em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1021009

RESUMO

APRESENTAÇÃO DO CASO: C. S. S., 69 anos, masculino, procedente de São Paulo-SP, natural de Siribinha-BA. Previamente hipertenso e dislipidêmico, iniciou quadro de insuficiência cardíaca (IC) há dois anos com diversas internações. Ecocardiograma Transtorácico revelou fração de ejeção de 58%, aumento importante biatrial, hipertrofia ventricular esquerda (HVE) concêntrica (espessura de septo=19mm e parede posterior=18mm), disfunção diastólica grau II e derrame pericárdico mínimo. Ressonância magnética do miocárdio demonstrou presença de realce tardio subendocárdico difuso, estendendose para valvas, paredes atriais e septo interatrial, sugerindo miocardiopatia infiltrativa. Biópsia de tecido subcutâneo abdominal inconclusiva, porém estudo genético mostrou positividade para o gene TTR VAL142IIe. Exame neurológico evidenciou forte evidência de Polineuropatia. Evoluiu com fibrilação atrial com resposta ventricular entre 60-70bpm e dispneia classe funcional III/IV apesar de tratamento clínico otimizado. Após discussão com Heart Team optado por implante de marcapasso, objetivando aumento de frequência cardíaca (FC) e consequente incremento no débito cardíaco. DISCUSSÃO: A amiloidose cardíaca (AC) é uma doença de diagnóstico difícil, condutas limitadas e prognóstico reservado. Um alto índice de suspeição é necessário para seu reconhecimento. No presente caso, o paciente evolui com IC com fração de ejeção preservada, refratária ao tratamento, com múltiplas internações. A frequência cardíaca em torno de 60-70bpm, pode contribuir para esta evolução desfavorável, já que na AC, a frequência cardíaca elevada é fundamental para aumentar o débito cardíaco, sendo contraindicado formalmente o uso de betabloqueadores e outras drogas bradicardizantes. Não havia indicação formal para o implante de marcapasso, porém, em Heart Team, foram considerados estes aspectos específicos da AC e decidido pelo implante do dispositivo, associado ao uso de diuréticos. Também indicamos o uso do Tafamidis atuando como um estabilizador cinético do tetrâmero da TTR. CONCLUSÃO: Grupos de Heart Team são importantes para decisões não constantes nas diretrizes atuais. IC refratária é uma patologia associada a alta mortalidade e morbidade e planejamentos terapêuticos capazes de intervir nesta evolução devem ser considerados. Deve-se valorizar o comportamento da frequência cardíaca nos pacientes com AC que podem se beneficiar de estratégias que visam o aumento desta. (AU)


Assuntos
Humanos , Masculino , Idoso , Amiloidose , Dislipidemias , Insuficiência Cardíaca , Hipertensão
20.
Rev Fac Cien Med Univ Nac Cordoba ; 76(3): 159-163, 2019 08 29.
Artigo em Espanhol | MEDLINE | ID: mdl-31465183

RESUMO

Background: Excess weight (EW) and alterations in lipid metabolism constitute risk factors for cardiovascular disease in adults and children. Prevalence of dyslipidemia in schoolchildren from Jujuy with EW is analyzed in this study. Methods: Cross-sectional descriptive study of 891 schoolchildren 10-14 years old (367 girls; 524 boys) from the province of Jujuy (Northwestern Argentina). Prevalence of dyslipidemia for Overweight (OW) and Obesity (OB) were calculated, according to the International Obesity Task Force cut-off points. Prevalence of lipid alterations were analyzed and 7 dyslipidemic profiles were established. Comparisons and associations between variables were analyzed by Chi-square test. Crude and adjusted odds ratio were estimated from a logistic regressions. Results: Regardless of sex and nutritional status, 13.7%, 21.8%, and 16.5% of schoolchildren showed high values of total cholesterol, triglycerides, and LDL cholesterol, respectively, and 20.3% had low HDL cholesterol. Significantly higher values of HDL cholesterol were found in OW, and of triglycerides in OB. A significant association was recorded between OB and high triglycerides. Schoolchildren with OB have a 54% more chances of showing at least one lipid alteration. Conclusion: EW, and especially OB, constitutes an important risk factor in the development of dyslipidemia in schoolchildren from Jujuy.


Assuntos
Dislipidemias/sangue , Dislipidemias/etiologia , Sobrepeso/complicações , Adolescente , Argentina/epidemiologia , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/etiologia , Criança , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Estudos Transversais , Dislipidemias/epidemiologia , Feminino , Humanos , Masculino , Obesidade/complicações , Sobrepeso/epidemiologia , Prevalência , Instituições Acadêmicas , Triglicerídeos/sangue
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA