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2.
Vnitr Lek ; 66(2): 116-120, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32942892

RESUMO

Celiac disease is a lifelong autoimmune disorder that occurs in genetically predisposed people when consuming gluten. Its prevalence is around 1% of the population with about twice higher proportion of women. Celiac disease is one of the most common causes of malabsorption, however, its manifestations can be quite diverse - from completely asymptomatic to fully developed malabsorption syndrome. Extraintestinal manifestations are a common finding in adults. The gold standard of diagnosis is the serological detection of specific antibodies (the serum tissue transglutaminase IgA antibodies) in combination with a typical histological finding from a duodenal biopsy. Causal treatment is a lifelong gluten-free diet. Strict adherence to gluten-free diet will reduce the risk of serious complications (intestinal T-cell lymphoma). In the following case report we present a case of a 58-year-old patient, who have been diagnosed with celiac disease at this age based on non-classical symptoms. Specifically, these were multiple pathological fractures from metabolic bone disease due to malabsorption of calcium and vitamin D and subsequent secondary hyperparathyroidism.


Assuntos
Doença Celíaca , Adulto , Autoanticorpos , Biópsia , Doença Celíaca/complicações , Doença Celíaca/diagnóstico , Dieta Livre de Glúten , Feminino , Glutens , Humanos , Pessoa de Meia-Idade
3.
PLoS One ; 15(9): e0238859, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32956371

RESUMO

OBJECTIVES: The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease. METHODS: This is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm2), corneal nerve branch density (no.mm2), corneal nerve fiber length (mm.mm2), corneal nerve fiber tortuosity and inferior whorl length (mm.mm2) were quantified manually. RESULTS: Corneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; P = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; P = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; P = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; P = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; P = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002). CONCLUSION: Corneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.


Assuntos
Doença Celíaca/complicações , Córnea/patologia , Oftalmopatias/diagnóstico , Fibras Nervosas/patologia , Estudos de Casos e Controles , Criança , Estudos de Coortes , Córnea/inervação , Estudos Transversais , Oftalmopatias/diagnóstico por imagem , Oftalmopatias/etiologia , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Microscopia Confocal , Prognóstico
4.
Am J Med Sci ; 360(3): 293-299, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32563569

RESUMO

Hyposplenism is associated with autoimmune diseases, inflammatory bowel disease, severe celiac disease, autoimmune thyroiditis, untreated HIV infection and chronic graft-versus-host disease. The aim of this study was to review the existing data on hyposplenism associated with celiac disease and Hashimoto's autoimmune thyroiditis. Our research was based on a clinical case concerning a 41-year-old female who presented with asthenia, fatigue, dyspepsia and chronic diarrhea. The medical history revealed autoimmune Hashimoto's thyroiditis, type 2 diabetes, fatty liver disease, chronic gastritis and thrombocytosis. Multiple investigations showed hyposplenism and complex autoimmune dysfunction with positive serum markers for celiac disease and type 1 autoimmune hepatitis along with minor symptomatology. The intestinal symptomatology of celiac disease is often hid by hypothyroidism-associated autoimmune thyroiditis. Asymptomatic or minimally symptomatic celiac disease associated with Hashimoto's autoimmune thyroiditis is diagnosed by biomarkers. Hyposplenism in celiac disease can occur regardless of the disease stage, latent or symptomatic.


Assuntos
Doença Celíaca/complicações , Doença de Hashimoto/complicações , Hepatite Autoimune/complicações , Baço/patologia , Adulto , Biópsia , Doença Celíaca/patologia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/patologia , Duodeno/patologia , Fígado Gorduroso/complicações , Feminino , Gastrite/complicações , Doença de Hashimoto/patologia , Hepatite Autoimune/patologia , Humanos , Imagem por Ressonância Magnética , Trombocitose/complicações
5.
Gastroenterol. latinoam ; 31(1): 39-42, mayo 2020.
Artigo em Espanhol | LILACS | ID: biblio-1103459

RESUMO

To date, it has not been described that celiac disease (CD) increases the risk of contagion by the new coronavirus SARS-CoV-2 nor the severity of the disease. The main risk factors for severe disease for this coronavirus are old male patients (> 65 years) with hypertension, diabetes, obesity, smoking, lung, cardiovascular and kidney diseases. The only treatment for CD is a gluten-free diet that improves the intestinal immune response. Adherence to treatment and follow-up of recommendations by experts during the COVID-19 period, would ensure celiac patients are better prepared for this pandemic.


Hasta la fecha no se ha descrito que la enfermedad celíaca (EC) incremente el riesgo de contagio por el nuevo coronavirus SARS-CoV-2 ni la gravedad de la enfermedad. Los principales factores de riego de enfermedad grave para este coronavirus son pacientes mayores de 65 años de sexo masculino con hipertensión, diabetes, obesidad, tabaquismo, y enfermedades pulmonar, cardiovascular y renal. El único tratamiento de la EC es la dieta libre de gluten que mejora la respuesta inmune intestinal. La adherencia al tratamiento y el seguimiento de recomendaciones dadas por expertos durante el período COVID-19, aseguraría a los enfermos celíacos, estar mejor preparados para esta pandemia.


Assuntos
Humanos , Pneumonia Viral/epidemiologia , Doença Celíaca/complicações , Doença Celíaca/terapia , Infecções por Coronavirus/epidemiologia , Betacoronavirus , Pneumonia Viral/prevenção & controle , Fatores de Risco , Infecções por Coronavirus/prevenção & controle , Suscetibilidade a Doenças , Pandemias
7.
J Ayub Med Coll Abbottabad ; 32(1): 18-23, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32468748

RESUMO

BACKGROUND: Irritable bowel syndrome (IBS) is a common clinical condition that is often diagnosed based on a set of clinical criteria. Celiac disease (CD) has a similar symptom. The study aims to estimate the prevalence of undiagnosed celiac disease (CD) in patients with criteria-positive IBS and compare with healthy control. METHODS: A Case control study conducted from August 2013 to July 2016. For the control group with negative ROME 3 criteria for IBS provided serum total immunoglobulin (IgA) level and serum tissue transglutaminase antibody (tTG IgA). The case group with positive criteria interviewed, examined, competed ROME 3 questionnaire and provided blood sample for haematology, biochemistry, and serum tTG IgA and IgG. Positive for CD invited for upper endoscopy and duodenal biopsy for evaluation of pathological involvement using the modified Marsh classification. RESULTS: Three controls (1.47%) and 21 cases (6.9%) had positive serology for CD. A statistically significant association found between serum tTG positivity and IBS and IBS-diarrhoea subtypes. No correlation was found between tTG positivity and age and sex of the case group. CONCLUSIONS: Celiac disease is common in IBS patients especially those with criteria-positive diagnosis. Serology screening for CD is helpful in IBS and IBS-D patients.


Assuntos
Doença Celíaca/diagnóstico , Doença Celíaca/epidemiologia , Síndrome do Intestino Irritável/complicações , Síndrome do Intestino Irritável/diagnóstico , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Doença Celíaca/complicações , Diarreia , Feminino , Proteínas de Ligação ao GTP , Humanos , Imunoglobulina A/sangue , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Prevalência , Inquéritos e Questionários , Transglutaminases , Adulto Jovem
8.
Rev Fac Cien Med Univ Nac Cordoba ; 77(1): 49-51, 2020 03 13.
Artigo em Espanhol | MEDLINE | ID: mdl-32238259

RESUMO

Introduction: celiac disease is a medical condition that is characterized by its varied forms of clinical presentation and its association with other autoimmune pathologies. The objective is to describe the case of a patient who presented for consultation due to alopecia areata. Methodology: observational, descriptive, retrospective study of a 24-year-old obese male Results: among the routine studies positive serology for celiac disease was detected and confirmed with digestive endoscopy. Conclusions: the alopecia areata of this patient allowed to reveal another autoimmune disease.


Assuntos
Alopecia em Áreas/etiologia , Doença Celíaca/complicações , Obesidade/complicações , Biópsia , Doença Celíaca/diagnóstico , Doença Celíaca/patologia , Humanos , Masculino , Estudos Retrospectivos , Adulto Jovem
9.
JAMA ; 323(13): 1277-1285, 2020 04 07.
Artigo em Inglês | MEDLINE | ID: mdl-32259229

RESUMO

Importance: Celiac disease may be associated with a modest but persistent increased long-term mortality risk. It is uncertain whether this risk has changed in the era of wider diagnosis rates, less severe clinical disease, and more widespread availability of gluten-free food. Objective: To evaluate the association between celiac disease and mortality risk in a population-based cohort in Sweden. Design, Setting, and Participants: All individuals in Sweden with celiac disease diagnosed between 1969 and 2017 were identified through the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) cohort. Participants (n = 49 829) were observed starting on the day of the biopsy. The final date of follow-up was December 31, 2017. Exposures: Celiac disease was defined by the presence of small intestinal villus atrophy on histopathology specimens during the years 1969-2017 from Sweden's 28 pathology departments. Each individual was matched with as many as 5 control participants in the general population by age, sex, county, and calendar period. Main Outcomes and Measures: The primary outcome was all-cause mortality, and the secondary outcome was cause-specific mortality. Patients with celiac disease were compared with controls using stratified Cox proportional modeling, stratifying by year of diagnosis. Results: There were 49 829 patients with celiac disease, including 24% who were diagnosed between the years 2010 and 2017. The mean (SD) age at diagnosis was 32.2 (25.2) years and 62.4% were women. During a median follow-up time of 12.5 years, 13.2% (n = 6596) died. Compared with controls (n = 246 426), overall mortality was increased in those with celiac disease (9.7 vs 8.6 deaths per 1000 person-years; absolute difference, 1.2 per 1000 person-years; hazard ratio [HR], 1.21 [95% CI, 1.17-1.25]). The relative increase in mortality risk was present in all age groups and was greatest in those diagnosed in the age range of 18 to 39 years (1.9 vs 1.1 per 1000 person-years; HR, 1.69 [95% CI, 1.47-1.94]; P values for heterogeneity comparing 18-39 years with 40-59 years and with ≥60 years were both <.001). Individuals with celiac disease were at increased risk of death from cardiovascular disease (3.5 vs 3.4 per 1000 person-years; HR, 1.08 [95% CI, 1.02-1.13]), cancer (2.7 vs 2.2 per 1000 person-years; HR, 1.29 [95% CI, 1.22-1.36]), and respiratory disease (0.6 vs 0.5 per 1000 person-years; HR, 1.21 [95% CI, 1.08-1.37]). When compared with controls, the overall mortality risk was greatest in the first year after diagnosis (15.3 vs 6.5 per 1000 person-years; HR, 2.34 [95% CI, 2.14-2.55]) but persisted beyond 10 years after diagnosis (10.5 vs 10.1 per 1000 person-years; HR, 1.15 [95% CI, 1.10-1.20]). The mortality risk was likewise present for patients diagnosed during the years 2010-2017 (7.5 vs 5.5 per 1000 person-years; HR, 1.35 [95% CI, 1.21-1.51]). Conclusions and Relevance: In a Swedish population studied between 1969 and 2017, a diagnosis of celiac disease compared with the general population was associated with a small but statistically significant increased mortality risk.


Assuntos
Doença Celíaca/mortalidade , Adolescente , Adulto , Fatores Etários , Atrofia , Doenças Cardiovasculares/mortalidade , Estudos de Casos e Controles , Doença Celíaca/complicações , Doença Celíaca/patologia , Criança , Escolaridade , Feminino , Humanos , Intestino Delgado/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias/mortalidade , Modelos de Riscos Proporcionais , Doenças Respiratórias/mortalidade , Estudos Retrospectivos , Fatores de Risco , Suécia/epidemiologia , Adulto Jovem
10.
Helicobacter ; 25(3): e12691, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32237105

RESUMO

BACKGROUND: An inverse association has been suggested between celiac disease (CD) and Helicobacter pylori (Hp) infection in children; however, there are inconsistent data. The purpose of this multi-center study is to evaluate the association between Hp and CD in childhood. METHODS: Children who underwent endoscopy between July 2016 and November 2017 in four pediatric gastroenterology centers were included in the study. Patients with a history of previous Hp eradication, antibiotic or acid-suppressive drug therapy in the last 4 weeks, and any underlying chronic disease were excluded. The presence of Hp infection was confirmed by both histopathology and the rapid urease test. The ones who had the diagnosis of CD were compared with the children who underwent endoscopy during the same period and had another diagnosis. Duodenal histopathology of children with CD was categorized according to the modified Marsh classification. RESULTS: Of 3056 endoscopies performed in the study period, 2484 cases were eligible for the study. A total of 482 CD patients (mean age: 9.71 ± 4.63 years, 58.5% girls) and 2060 controls (mean age: 9.92 ± 4.66 years, 54.6% girls) were included in the study. The rate of Hp infection was significantly lower in CD group (26.3% vs 50.1%, P < .01). The difference was prominent even in children younger than 6 years old (P < .01). There was no correlation between Hp infection and the modified Marsh scores in CD (P > .05). CONCLUSION: In this cross-sectional study, where Hp infection is common even in the pediatric population, the frequency of Hp infection was significantly lower in children with CD compared with the controls. Systematic cohort studies are necessary to clarify causal association between Hp infection and the development of celiac disease.


Assuntos
Doença Celíaca/complicações , Infecções por Helicobacter , Adolescente , Criança , Pré-Escolar , Estudos de Coortes , Estudos Transversais , Duodeno/patologia , Feminino , Infecções por Helicobacter/complicações , Helicobacter pylori , Humanos , Masculino
11.
Rev Assoc Med Bras (1992) ; 66(1): 55-60, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32130382

RESUMO

OBJECTIVE: It has been observed that celiac disease (CD) is not restricted to a single type characterized by diarrhea but also has atypical, asymptomatic (silent), and latent forms. The prevalence of this autoimmune disease, which affects approximately 1% of the world, is estimated to be around 3%, including atypical and asymptomatic cases. In our study, we aimed to evaluate adult celiac patients. METHODS: Between December 2008-2015, patients diagnosed with CD over the age of 18 years old were included in the study. Patients' symptoms at admission, frequency and type of anemia, transaminase levels, and celiac antibody positivity, and autoimmune diseases diagnosed at follow up were evaluated retrospectively. RESULTS: Of 195 patients, 151 (77.4%) were female. The mean age of the patients was 35.73 ± 12.19 years (range, 18-71 years). A hundred patients (51.3%) had gastrointestinal symptoms. At the time of admission, 118 patients (60.5%) had anemia, and 52 (26.7%) had hypertransaminasemia. During the mean follow-up period of 58 months (36-120 months), 84 (43.1%) of the patients presented at least one autoimmune disease, and this rate was 96.6% in individuals diagnosed above the age of 50 years. CONCLUSION: In adult CD, resistant anemia, dyspepsia, and hypertransaminasemia are very common findings at the time of diagnosis, and the association with other autoimmune diseases, especially Hashimoto's thyroiditis, is high.


Assuntos
Anemia/epidemiologia , Doenças Autoimunes/epidemiologia , Doença Celíaca/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Anemia/complicações , Doenças Autoimunes/complicações , Doença Celíaca/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Estatísticas não Paramétricas , Centros de Atenção Terciária/estatística & dados numéricos , Doenças da Glândula Tireoide/complicações , Doenças da Glândula Tireoide/epidemiologia , Transaminases/sangue , Turquia/epidemiologia , Adulto Jovem
12.
Endocr Pract ; 26(6): 660-667, 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32160043

RESUMO

Objective: It is unclear whether the institution of gluten-free diet (GFD) is beneficial in patients with type 1 diabetes (T1DM) and subclinical celiac disease (CD). Our primary objective was to evaluate the effect of GFD on the frequency of hypoglycemia, in patients with T1DM and subclinical CD. Our secondary objective was to investigate the effect of GFD on height, weight, glycosylated hemoglobin (HbA1c), insulin dose requirement, and bone mineral homeostasis. Methods: We carried out a prospective open label randomized controlled trial (RCT). Patients with T1DM and subclinical CD were randomized to receive GFD or a normal diet for 1 year. The primary outcome was the frequency of hypoglycemic episodes (blood glucose <70 mg/dL) measured by self-monitoring of blood glucose (SMBG) at the sixth month of the study in the 2 groups. Results: Screening for CD was carried out in 320 T1DM patients. Thirty eligible patients were randomized to receive GFD (n = 15) or a normal diet (n = 15). The mean number of hypoglycemic episodes/month recorded by SMBG and the mean time spent in hypoglycemia measured by CGM (minutes) in the GFD group versus the non-GFD group at six months was 2.3 minutes versus 3.4 minutes (P = .5) and 124.1 minutes versus 356.9 minutes (P = .1), respectively. The mean number of hypoglycemic episodes/month significantly declined in the GFD group (3.5 episodes at baseline versus 2.3 episodes at the sixth month; P = .03). The mean HbA1c declined by 0.73% in the GFD group and rose by 0.99% in non-GFD group at study completion. Conclusion: This is the first RCT to assess the effect of GFD in T1DM and subclinical CD. A trend towards a decrease in hypoglycemic episodes and better glycemic control was seen in patients receiving GFD. Abbreviations: BMC = bone mineral content; BMI = body mass index; CD = celiac disease; CGM = continuous glucose monitoring; GFD = gluten-free diet; Hb = hemoglobin; HbA1c = glycosylated hemoglobin; iPTH = intact parathyroid hormone; RCT = randomized controlled trial; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus; tTG-IgA = tissue transglutaminase immunoglobulin A.


Assuntos
Doença Celíaca , Diabetes Mellitus Tipo 1 , Dieta Livre de Glúten , Glicemia , Doença Celíaca/complicações , Diabetes Mellitus Tipo 1/complicações , Hemoglobina A Glicada , Humanos , Estudos Prospectivos
14.
Nutrients ; 12(2)2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-32069794

RESUMO

Dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is characterized by transglutaminase (TG) 3-targeted dermal immunoglobulin A (IgA) deposits. The treatment for DH is the same as for coeliac disease, namely a life-long gluten-free diet. DH patients typically have gluten-dependent circulating autoantibodies targeting TG3 and TG2, and plasma cells secreting such autoantibodies have been detected in the small intestinal mucosa. This study investigates the gluten-responsiveness of intestinal TG3 and TG2 antibody-secreting plasma cells in 16 treated DH patients undergoing a gluten challenge. The frequency of both plasma cell populations increased significantly during the challenge, and their frequency correlated with the corresponding serum autoantibody levels at post-challenge. TG3-specific plasma cells were absent in all 18 untreated coeliac disease patients and seven non-coeliac control subjects on gluten-containing diets. These findings indicate that, in DH, both intestinal TG3- and TG2-antibody secreting plasma cells are gluten-dependent, and that TG3-antibody secreting plasma cells are DH-specific.


Assuntos
Autoanticorpos/sangue , Dermatite Herpetiforme/imunologia , Proteínas de Ligação ao GTP/imunologia , Glutens/efeitos adversos , Plasmócitos/imunologia , Transglutaminases/imunologia , Adulto , Idoso , Doença Celíaca/complicações , Doença Celíaca/imunologia , Dieta Livre de Glúten , Feminino , Glutens/imunologia , Humanos , Mucosa Intestinal/imunologia , Intestino Delgado/imunologia , Masculino , Pessoa de Meia-Idade
16.
Nutrients ; 12(1)2020 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-31947666

RESUMO

Coeliac disease is a common small intestinal enteropathy which manifests following ingestion of gluten in genetically susceptible individuals. Since gluten was identified as the driving factor in coeliac disease, the gluten-free diet (GFD) has remained the mainstay of treatment. While most individuals will display improvement in symptoms and signs of coeliac disease following institution of the GFD, up to 30% will continue to experience symptoms and/or have persisting intestinal inflammation. These individuals can be classified as having non-responsive coeliac disease (NRCD), which may be associated with dietary indiscretion, slow healing, refractory coeliac disease, and/or an alternative condition. The purpose of this review is to provide an overview of the causes of NRCD in adults, highlight a systematic approach to investigate these patients, and appraise the latest management aspects of this subset of coeliac disease.


Assuntos
Doença Celíaca/dietoterapia , Dieta Livre de Glúten , Adulto , Doença Celíaca/complicações , Inglaterra , Feminino , Glutens/análise , Humanos , Síndromes de Malabsorção/complicações , Síndromes de Malabsorção/dietoterapia , Masculino , Cooperação do Paciente , Medicina Estatal , Falha de Tratamento
17.
Nutrients ; 12(1)2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-31935859

RESUMO

The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994-2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.


Assuntos
Índice de Massa Corporal , Doença Celíaca/complicações , Dieta Livre de Glúten , Estado Nutricional , Obesidade Pediátrica , Magreza/etiologia , Ganho de Peso , Fatores Etários , Autoanticorpos , Doença Celíaca/diagnóstico , Doença Celíaca/dietoterapia , Doença Celíaca/epidemiologia , Criança , Pré-Escolar , Chile/epidemiologia , Insuficiência de Crescimento/diagnóstico , Insuficiência de Crescimento/dietoterapia , Insuficiência de Crescimento/epidemiologia , Insuficiência de Crescimento/etiologia , Feminino , Gastroenteropatias/diagnóstico , Gastroenteropatias/dietoterapia , Gastroenteropatias/epidemiologia , Gastroenteropatias/etiologia , Hospitais , Humanos , Lactente , Masculino , Sobrepeso , Prevalência , Magreza/diagnóstico , Magreza/dietoterapia , Magreza/epidemiologia
20.
Pol J Pathol ; 70(3): 155-161, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31820858

RESUMO

Organic basis of gastrointestinal symptoms is in the scope of many specialists. In this article lymphocytic gastritis, relatively newly described and not widely-known entity is presented. The lesion is characterized by presence of numerous mature lymphocytes in the surface and foveolar epithelium, as well as lymphocytic infiltration of the lamina propria. According to the definition at least 25 lymphocytes per 100 gastric epithelial cells is now required for the diagnosis. Literature found in wide range of databases was searched for morphological features of lymphocytic gastritis and its relationship with others coexisting or predisposing conditions or lesions. A strong positive correlation between celiac disease and Helicobacter pylori infection, and occurrence and severity of lymphocytic gastritis was revealed. A relationship was also found between lymphocytic gastritis and gastric lymphomas and other conditions.


Assuntos
Doença Celíaca/complicações , Gastrite/patologia , Infecções por Helicobacter/complicações , Linfócitos , Mucosa Gástrica/patologia , Humanos
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