Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 3.842
Filtrar
1.
BMC Med Genet ; 21(1): 21, 2020 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-32005172

RESUMO

BACKGROUND: More than 95% of individuals with RTT have mutations in methyl-CpG-binding protein 2 (MECP2), whose protein product modulates gene transcription. The disorder is caused by mutations in a single gene and the disease severity in affected individuals can be quite variable. Specific MECP2 mutations may lead phenotypic variability and different degrees of disease severity. It is known that low bone mass is a frequent and early complication of subjects with Rett syndrome. As a consequence of the low bone mass Rett girls are at an increased risk of fragility fractures. This study aimed to investigate if specific MECP2 mutations may affects the degree of involvement of the bone status in Rett subjects. METHODS: In 232 women with Rett syndrome (mean age 13.8 ± 8.3 yrs) we measured bone mineral density at whole body and at femur (BMD-FN and BMD-TH) by using a DXA machine (Hologic QDR 4500). QUS parameters were assessed at phalanxes by Bone Profiler-IGEA (amplitude dependent speed of sound: AD-SoS and bone transmission time: BTT). Moreover, ambulation capacity (independent or assisted), fracture history and presence of scoliosis were assessed. We divided the subjects with the most common point mutations in two group based on genotype-phenotype severity; in particular, there has been consensus in recognising that the mutations R106T, R168X, R255X, R270X are considered more severe. RESULTS: As aspect, BMD-WB, BMD-FN and BMD-TH were lower in subjects with Rett syndrome that present the most severe mutations with respect to subjects with Rett syndrome with less severe mutations, but the difference was statistically significant only for BMD-FN and BMD-TH (p < 0.05). Also both AD-SoS and BTT values were lower in subjects that present the most severe mutations with respect to less severe mutations but the difference was not statistically significant. Moreover, subjects with Rett syndrome with more severe mutations present a higher prevalence of scoliosis (p < 0.05) and of inability to walk (p < 0.05). CONCLUSION: This study confirms that MECP2 mutation type is a strong predictor of disease severity in subjects with Rett syndrome. In particular, the subjects with more severe mutation present a greater deterioration of bone status, and a higher prevalence of scoliosis and inability to walk.


Assuntos
Doenças Ósseas/genética , Proteína 2 de Ligação a Metil-CpG/genética , Osteoporose/genética , Síndrome de Rett/genética , Adolescente , Adulto , Densidade Óssea/genética , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/fisiopatologia , Criança , Pré-Escolar , Feminino , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/genética , Fraturas Ósseas/fisiopatologia , Humanos , Masculino , Mutação , Osteoporose/diagnóstico por imagem , Osteoporose/fisiopatologia , Síndrome de Rett/diagnóstico por imagem , Síndrome de Rett/fisiopatologia , Escoliose/diagnóstico por imagem , Escoliose/genética , Escoliose/fisiopatologia , Índice de Gravidade de Doença , Adulto Jovem
2.
Medicine (Baltimore) ; 99(3): e18784, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32011474

RESUMO

RATIONALE: Allograft-prosthetic composites (APCs) and proximal femoral replacement have been applied for reconstruction of severe segmental femoral bone loss in revision total hip arthroplasty. The outcomes are encouraging but the complication rate is relatively high. Considering the high complication rates and mixed results of APCs and megaprosthesis, we presented a case using personalized 3D printed Titanium sleeve-prosthetic composite for reconstruction of segmental bone defect. PATIENT CONCERNS: A 73-year-old woman presented to the emergency department on account of acute severe pain of the left hip without history of trauma. She had undergone a cemented total hip arthroplasty for osteonecrosis of femoral head at the left side in 2000. In 2013 she underwent a cemented revision total hip arthroplasty as a result of aseptic loosening of hip prosthesis. She denied obvious discomfort prior to this episode since the revision surgery in 2013. DIAGNOSIS: According to the clinical history, imaging and physical examination, we confirmed the diagnosis of severe segmental bone loss of proximal femur and fracture of prosthetic stem. The femoral bone defect was evaluated using the Paprosky classification system and rated as Type 3B, and the acetabular bone defect was rated as Type 2C. INTERVENTIONS: In this study, we present the first case of severe segmental bone loss of proximal femur in revision total hip arthroplasty that was successfully treated using personalized 3D printed Titanium sleeve-prosthetic composite OUTCOMES:: At the 2-year follow-up, the patient was symptom free with a Harris Hip Score of 91. Radiographs showed excellent osteointegration between the interface of sleeve-prosthetic composite and the host bone, with no signs of implant loosening or subsidence. LESSONS: Despite the absence of long term results of 3D printed Titanium sleeve-prosthetic composite reconstruction, the good clinical and radiological outcome at 2 years follow up implied its potential role for reconstruction of segmental femoral bone defect in revision THA.


Assuntos
Artroplastia de Quadril , Doenças Ósseas/cirurgia , Prótese de Quadril , Medicina de Precisão , Impressão Tridimensional , Desenho de Prótese/métodos , Idoso , Doenças Ósseas/diagnóstico por imagem , Feminino , Fêmur , Humanos , Medicina de Precisão/métodos , Falha de Prótese , Reoperação , Titânio
3.
Medicine (Baltimore) ; 98(51): e18431, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31861011

RESUMO

The aim of this study was to measure the urate volume within tophus and bone erosion volume using dual-energy computed tomography in patients with tophaceous gout. Furthermore, our study aims to quantitatively analyze the relationship between monosodium urate (MSU) crystal deposition and bone erosion according to the anatomic location of urate deposition.Seventy-seven subjects with chronic gout were positively identified for the presence of urate deposition. Only 27 subjects identified for the presence of urate in contact with bone erosion were included in this study. The urate volumes and associated erosion volumes were measured. The relationships between urate within tophus and bone erosion were separately analyzed according to the anatomic location of urate deposition.Twenty-seven subjects were all male (100%) with a median (interquartile range, IQR) age of 52 (45-61) years. From all the subjects, 103 tophi depositions were identified in contact with bone erosion, including 58/103 tophi that contained an intraosseous component and 45/103 nonintraosseous tophi. Tophi containing intraosseous components were larger than nonintraosseous tophi (urate volume: median [IQR] 45.64 [4.79-250.89] mm vs 19.32 [6.97-46.71] mm, P = .035) and caused greater bone erosion (erosion volume: 249.03 [147.08-845.33] mm vs 69.07 [32.88-111.24] mm, P < .001). Almost all erosion volumes were larger than urate volumes in nonperiarticular tophi, in contrast to most erosion volumes, which were less than urate volumes in the tophi that contained a periarticular component (odds ratio, 95% confidence interval: 74.00, 14.70-372.60; P < .001). Urate volume and erosion volume demonstrated positive correlations in intraosseous tophi, intraosseous-intra-articular-periarticular tophi, and intraosseous-intra-articular tophi (rs = 0.761, rs = 0.695, rs = 0.629, respectively, P < .05).MSU crystal deposition shows a promoting effect on the development of bone erosions in varying degrees, associated with the location of MSU crystals deposited in the joints. The intraosseous tophi contribute the most to bone erosions, followed by intra-articular tophi, and periarticular tophi.


Assuntos
Doenças Ósseas/etiologia , Gota/complicações , Ácido Úrico/metabolismo , Adulto , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/metabolismo , Gota/diagnóstico por imagem , Gota/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X/métodos
5.
Br J Radiol ; 92(1103): 20190249, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31469323

RESUMO

OBJECTIVE: The frequency of enostosis incidentally found on CT and CT attenuation value to distinguish them from untreated osteoblastic metastases (UOM). METHODS: Enostosis group: 46 polytrauma patients underwent thoracoabdominal CT. Inclusion criteria: age range 14-35 years. Exclusion criteria: cancer, previous fractures. UOM group: 20 patients with radiological diagnosis of UOM. Analyzed data: number, size, location and density of enostoses and metastases. The density was measured with the broadest possible region of interest at the center of the lesion by two radiologists independently. Receiver operatingcharacteristic analysis to determine the sensitivity and specificity, area under the curve 95% confidence intervals and cutoff values of CT density to differentiate metastases from enostoses. RESULTS: Patients were 28 ± 7 years old (72% males). 41 (89%) patients had 124 enostoses (2-15 mm) with an average density of 1007 ± 122 Hounsfiled unit (HU, observer1) and 1052 ± 107 (observer2). The most common sites of occurrence were the proximal femur (34%), the pelvis (22%), the acetabulum (20%), the proximal humerus (11%), the vertebrae (11%) and the rib (2%). 13 patients had 1 bone island, 8 patients had 2, 9 cases had 3 and 11 cases had more than 3 enostoses. Overall, 114 UOM were evaluated, their average density was 728 ± 163 HU (observer1) and 712 ± 178 HU (observer2). The area under the curve value of mean density to distinguish enostoses from UOM was 0,982. Using a cut-off of 881 HU for mean density, sensitivity was 98% and specificity 95%. CONCLUSION: The frequency of enostosis in this study is 89%. The average density identified can help to distinguish enostoses from UOM. ADVANCES IN KNOWLEDGE: We report the exact frequency of enostosis.


Assuntos
Doenças Ósseas/diagnóstico por imagem , Adolescente , Adulto , Densidade Óssea/fisiologia , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/fisiopatologia , Neoplasias Ósseas/secundário , Diagnóstico Diferencial , Feminino , Humanos , Achados Incidentais , Masculino , Estudos Retrospectivos , Adulto Jovem
6.
J Orthop Surg Res ; 14(1): 280, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31462273

RESUMO

BACKGROUND: Revision total knee arthroplasty (rTKA) is a demanding procedure, with a high complication and failure rate and a high rate of bone losses and poor bone quality. Different classifications for bone losses have been proposed, but they do not consider bone quality, which may affect implant fixation. The aim of this study is to describe the outcomes of a consecutive series of rTKA. Furthermore, a modified bone loss classification will be proposed based also on bone quality. Finally, the association between radiolucent line (RLL) development and different risk factors will be evaluated. METHODS: All the patients who underwent rTKA between 2008 and 2016 in the same institution were included. rTKAs were performed by the same surgeon according to the three-step technique. Bone losses were classified according to the proposed classification, including bone quality evaluation. The Knee Scoring System (KSS), the Hospital for Special Surgery Knee Score (HSS), and the SF-12 were used for the clinical evaluation. Radiological evaluation was performed according to the Knee Society Roentgenographic Evaluation System. Different possible risk factors (i.e., gender, age, amount of bone losses) associated to RLL development were identified, and this association was evaluated using logistic regression. RESULTS: Fifty-one patients (53 knees) were included (60.8% female, average age 71.5 years). The average follow-up was 56.6 months (range 24-182). The most frequent cause of failure was aseptic loosening (41.5%). 18.9% of the cases demonstrated poor bone quality. Bone losses were treated according to the proposed algorithm. In all the cases, there was a significant improvement in all the scores (P < 0.05). The average post-operative range of motion was 110.5° (SD 10.7). At the radiological evaluation, all the implants resulted well aligned, with 15.1% of non-progressive RLL. There were 2 failures, with a cumulative survivorship of 92.1% at the last follow-up (SD 5.3%). At the logistic regression, none of the evaluated variables resulted associated to RLL development. CONCLUSION: rTKA is a demanding procedure, and adequate treatment of bone losses is mandatory to achieve good results. However, also bone quality should be taken into consideration when approaching bone losses, and the proposed classification may need surgeons after an adequate validation. LEVEL OF EVIDENCE: Level IV.


Assuntos
Artroplastia do Joelho/normas , Doenças Ósseas/cirurgia , Complicações Pós-Operatórias/cirurgia , Qualidade da Assistência à Saúde/normas , Reoperação/normas , Idoso , Idoso de 80 Anos ou mais , Artroplastia do Joelho/tendências , Doenças Ósseas/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico por imagem , Estudos Prospectivos , Qualidade da Assistência à Saúde/tendências , Reoperação/tendências , Resultado do Tratamento
8.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 38(4): 218-223, jul.-ago. 2019. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-ET5-17

RESUMO

OBJETIVOS: Determinar la factibilidad de la freehand-SPECT en la identificación de lesiones óseas con captación de 99mTc-HDP evaluando los datos generados mediante la utilización de sistemas de navegación con realidad aumentada y virtual. MATERIAL Y MÉTODOS: Se generaron 21 imágenes 3D utilizando freehand-SPECT con una gammacámara manual en 20 pacientes referidos para gammagrafía ósea con 99mTc-HDP. Las imágenes freehand-SPECT y las gammagrafías fueron comparadas y se analizó el grado de concordancia. Además, se evaluó la factibilidad de navegación hacia las lesiones óseas hipercaptantes. RESULTADOS: En el 86% de los casos freehand-SPECT mostró una buena concordancia con las imágenes correspondientes de la gammagrafía ósea. En lesiones con una señal lesión/fondo de>1,36 freehand-SPECT pudo automáticamente proporcionar puntos de referencia segmentados con finalidad de navegación. En el 14% de los casos (índice lesión/fondo: valor promedio 1,82, rango 1,0-3,4) las imágenes freehand-SPECT mostraron concordancia intermedia debido a que estaban localizadas en regiones anatómicas difíciles o asociadas con una gammagrafía ósea negativa y fueron consideradas como no apropiadas para la navegación dirigida. CONCLUSIÓN: En este estudio piloto, se encontró un 86% de los casos apropiados para propósitos de navegación con una buena concordancia entre freehand-SPECT y la gammagrafía ósea. Un índice lesión/fondo de 1,36 o más facilitó la navegación con freehand-SPECT. La alta calidad de las imágenes generadas con freehand-SPECT potencialmente asegura una exitosa estrategia de navegación para biopsias óseas guiadas


PURPUSE: To assess the feasibility of using freehand Single Photon Emission Computed Tomography (freehandSPECT) for the identification of technetium-99m-hydroxydiphosphonate (99mTc-HDP) positive bone lesions and to evaluate the possibility of using these imaging data-sets for augmented- and virtual-reality based navigation approaches. MATERIAL AND METHODS: In 20 consecutive patients referred for scintigraphy with 99mTc-HDP, 21 three-dimensional freehandSPECT-images were generated using a handheld gamma camera. Concordance of the two different data sets was ranked. Furthermore, feasibility of segmenting the hotspot of tracer accumulation for navigation purposes was assessed. RESULTS: In 86% of the cases freehandSPECT images showed good concordance with the corresponding part of the scintigraphic images. In lesions with a signal to background ratio (SBR) >1.36, freehandSPECT provided an automatically segmented reference point for navigation purposes. In 14% of the cases (average SBR 1.82, range 1.0-3.4) freehandSPECT images showed intermediate concordance due to difficult anatomical area or negative bone scintigraphy and could not be used as navigation targets. CONCLUSION: In this pilot study, in 86% of the cases freehandSPECT demonstrated good concordance with traditional scintigraphy. A lesion with a SBR of 1.36 or more was suitable for navigation. These high-quality freehandSPECT images supported the future exploration navigation strategies, e. g. guided needle biopsies


Assuntos
Humanos , Biópsia por Agulha/métodos , Doenças Ósseas/diagnóstico por imagem , Câmaras gama , Biópsia Guiada por Imagem/métodos , Medronato de Tecnécio Tc 99m/análogos & derivados , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Desenho de Equipamento , Projetos Piloto , Compostos Radiofarmacêuticos/farmacocinética , Medronato de Tecnécio Tc 99m/farmacocinética , Tomografia Computadorizada de Emissão de Fóton Único/instrumentação , Imagem Corporal Total , Doenças Ósseas/patologia , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/secundário , Método Duplo-Cego
9.
BMC Musculoskelet Disord ; 20(1): 330, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31307450

RESUMO

BACKGROUND: The aetiology of bone marrow oedema-like abnormalities (BMOA) seen on magnetic resonance imaging (MRI) is as yet not fully understood. The current study aimed to investigate the potential of projection radiography and Raman microspectroscopy to provide information regarding the underlying physiological changes associated with BMOA in equine bone samples. METHODS: MRI was used to assess 65 limbs from 43 horses. A subset of 13 limbs provided 25 samples, 8 with BMOA present and 17 as controls; these were examined with projection radiography to assess bone mineral density and Raman spectroscopy to assess bone composition. Statistical analysis was conducted using SPSS, the relationship between BMOA and age was tested using binary logistic regression, other outcome measures via unpaired t-tests. RESULTS: Overall BMOA was found to be associated with locally increased bone density (p = 0.011), suggesting increased bone formation; however, no measurable changes relating to bone remodelling were found, and there were no detectable changes in the chemical composition of bone. CONCLUSIONS: BMOA is associated with locally increased bone density, without an associated change in the chemical composition of bone, suggesting this is not linked to BMOA. The presence of increased bone density associated with BMOA does appear to suggest that an increased amount of bone formation is occurring in these regions, but as Raman microspectroscopy data do not demonstrate any significant changes in bone chemical composition associated with BMOA, it would appear that the increased bone volume is due to a greater amount of bone being formed rather than an imbalance in relation to bone remodelling. The study provides a proof of principle for the use of Raman microspectroscopy and projection radiography in in vitro studies of BMOA.


Assuntos
Densidade Óssea , Doenças Ósseas/veterinária , Doenças da Medula Óssea/veterinária , Osso e Ossos/química , Edema/veterinária , Animais , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/patologia , Doenças da Medula Óssea/diagnóstico por imagem , Osso e Ossos/diagnóstico por imagem , Osso e Ossos/patologia , Edema/diagnóstico por imagem , Edema/patologia , Membro Anterior , Cavalos , Imagem por Ressonância Magnética , Espectroscopia de Ressonância Magnética/métodos , Estudo de Prova de Conceito , Análise Espectral Raman/métodos
10.
J Zoo Wildl Med ; 50(2): 437-446, 2019 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-31260211

RESUMO

Hypertrophic osteopathy, a syndrome characterized by painful distal limb swelling and proliferative periosteal reaction, primarily involves the metacarpal and metatarsal bones and phalanges. Lesions are often bilaterally symmetric and typically affect all four limbs. Hypertrophic osteopathy is frequently associated with primary intrathoracic disease, though this condition has also been reported secondary to intra-abdominal and intrapelvic disease and associated with pregnancy in both people and horses. Over a 20-yr period, five adult female Sichuan takin (Budorcas taxicolor tibetana), with 13 total pregnancies, were evaluated because of lameness and distal limb swelling. These clinical signs were observed between 2 and 32 days (mean = 19 days) prior to parturition (gestation period in takin approximately 200-240 days) and resolved in all animals following parturition. Lameness and limb swelling resolved between 8 and 168 days (median = 15 days) after parturition. Sixteen radiographic examinations, from four of the individuals, documented proliferative periosteal reaction, primarily of the metacarpal bones, metatarsal bones, and phalanges. The clinical progression, resolution of signs, and radiographic features in these cases are consistent with hypertrophic osteopathy, secondary to pregnancy. This is the first report describing presumptive hypertrophic osteopathy in takin.


Assuntos
Doenças Ósseas/veterinária , Período Periparto , Ruminantes , Animais , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/etiologia , Doenças Ósseas/patologia , Feminino , Membro Anterior/diagnóstico por imagem , Membro Anterior/patologia , Membro Posterior/diagnóstico por imagem , Membro Posterior/patologia , Gravidez
11.
J Craniofac Surg ; 30(6): 1760-1763, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31261317

RESUMO

BACKGROUND: While the risk for intracranial extension of midline nasoglabellar dermoid cysts is well-described, the risk in non-midline dermoid cysts and role of preoperative imaging in these lesions is less understood. This study aims to address this gap and provide preoperative recommendations. MATERIALS AND METHODS: A retrospective review was performed evaluating patients who underwent excision of craniofacial dermoid cysts by a single surgeon. Findings on preoperative physical examination and imaging modalities were compared to intraoperative findings to assess effectiveness of each in predicting bony erosion. A treatment algorithm is proposed. RESULTS: Twenty-eight patients were included and 50% had intraoperatively confirmed bony erosion. Bony erosion was identified in 100% of lesions immobile on examination, compared to 30% of mobile lesions (P = 0.001). Bony erosion was identified in 40.9% of lateral brow cysts compared to 83.3% of lesions located elsewhere (P = 0.03), in 60% of patients with periorbital sequelae compared to 47.8% without periorbital sequelae, and in 66.7% of patients with reported change in cyst size with Valsalva compared to 48.0% without change with Valsalva. Sensitivities for preoperative identification of bony erosion were as follows: physical examination 57.1%, US 11.1%, MRI 66.7%, and CT 100%. CONCLUSIONS: A management algorithm for non-midline dermoid cysts is presented. CT or MRI is recommended for lesions that are immobile, in atypical locations, or have associated periorbital sequelae or change with Valsalva. The authors feel there is no role for ultrasound and don't recommend routine imaging in patients with non-midline dermoid cysts without features suggestive of bony erosion.


Assuntos
Doenças Ósseas/diagnóstico por imagem , Cisto Dermoide/diagnóstico por imagem , Crânio/diagnóstico por imagem , Doenças Ósseas/etiologia , Criança , Pré-Escolar , Cisto Dermoide/complicações , Cisto Dermoide/cirurgia , Feminino , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Estudos Retrospectivos
12.
Clin Nucl Med ; 44(9): e519-e521, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31348077

RESUMO

A 57-year-old man with stage IIIB malignant melanoma of unknown primary presented for pretherapy FDG PET/CT that demonstrated metastatic left cervical lymph node with no other site of involvement. Following left neck dissection, nivolumab was initiated. Follow-up FDG PET/CT 3 months after initiation of nivolumab demonstrated extensive radiotracer-avid chest lymphadenopathy and multiple bone lesions. Ultrasound-guided endobronchial biopsy of the mediastinal lymph nodes demonstrated sarcoidosis.


Assuntos
Doenças Ósseas/induzido quimicamente , Pneumopatias/induzido quimicamente , Melanoma/tratamento farmacológico , Neoplasias Primárias Desconhecidas/tratamento farmacológico , Nivolumabe/efeitos adversos , Sarcoidose/induzido quimicamente , Sarcoidose/diagnóstico por imagem , Doenças Ósseas/diagnóstico por imagem , Fluordesoxiglucose F18 , Humanos , Pneumopatias/diagnóstico por imagem , Linfadenopatia/induzido quimicamente , Masculino , Pessoa de Meia-Idade , Nivolumabe/uso terapêutico , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
14.
J Vet Med Sci ; 81(9): 1348-1350, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31341135

RESUMO

A wild adult Eurasian scops owl (Otus scops), which was unable to fly, was rescued. Physical examination revealed a sticky exudate around the glottis. Heterophilic leukocytosis was identified through complete blood count, and radiography revealed a marked elevated density of posterior air sacs and inner cavities in both sides of the humerus and femur. Fungal cultures of samples taken from the owl suggested a respiratory fungal infection. Through molecular typing, the fungus was identified as Epicoccum nigrum. The owl was treated with oral itraconazole and broad-spectrum antibiotics. After one month, the inner cavities of pneumatic bones were slightly distinguishable by radiography and the owl started to fly well. Two months later, the air sac and all pneumatic bones displayed normal appearance.


Assuntos
Ascomicetos/isolamento & purificação , Doenças Ósseas/veterinária , Micoses/veterinária , Estrigiformes/microbiologia , Sacos Aéreos/microbiologia , Animais , Anti-Infecciosos/administração & dosagem , Antifúngicos/administração & dosagem , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/tratamento farmacológico , Doenças Ósseas/microbiologia , Itraconazol/administração & dosagem , Micoses/tratamento farmacológico , Micoses/microbiologia , República da Coreia , Infecções Respiratórias/microbiologia , Infecções Respiratórias/veterinária
15.
Semin Musculoskelet Radiol ; 23(3): 324-344, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31163506

RESUMO

This article consists of a series of clinical cases presented during the ESSR Quiz session at the 25th Annual Meeting of the European Society of Musculoskeletal Radiology in Amsterdam 2018. The first section contains the clinical information and an initial set of images for each case. The second section reveals the answers along with additional imaging followed by a short discussion about the pathologic processes presented. This article provides self-assessment and at the same time refreshes the reader's knowledge about some common and not-so-common clinical conditions that a radiologist may encounter during clinical practice.


Assuntos
Doenças Ósseas/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Artropatias/diagnóstico por imagem , Doenças da Coluna Vertebral/diagnóstico por imagem , Adolescente , Adulto , Idoso , Criança , Europa (Continente) , Feminino , Antebraço/diagnóstico por imagem , Humanos , Articulações/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Pescoço/diagnóstico por imagem , Pelve/diagnóstico por imagem , Radiologia , Sociedades Médicas , Coluna Vertebral/diagnóstico por imagem , Parede Torácica/diagnóstico por imagem
16.
Semin Musculoskelet Radiol ; 23(3): e58-e67, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31163510

RESUMO

Pain around the hip and pelvis is a very common condition. Pain may be generated within the joint space (i.e. the hip joint itself, the sacroiliac joints or the pubic symphysis) or from surrounding myotendinous, bursal, or nerve structures. Over the years, percutaneous musculoskeletal procedures have become increasingly popular to diagnose and treat painful conditions around the hip and the pelvis. Most intra- and extra-articular procedures are performed under ultrasound guidance. This article reviews the most common diagnostic and therapeutic procedures that can be performed around the hip and the pelvis under ultrasound guidance.


Assuntos
Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/tratamento farmacológico , Neuropatia Femoral/tratamento farmacológico , Artropatias/diagnóstico por imagem , Artropatias/tratamento farmacológico , Ultrassonografia de Intervenção/métodos , Corticosteroides/administração & dosagem , Anestésicos/administração & dosagem , Neuropatia Femoral/diagnóstico por imagem , Articulação do Quadril/diagnóstico por imagem , Humanos , Ácido Hialurônico/administração & dosagem , Dor/tratamento farmacológico , Ossos Pélvicos/diagnóstico por imagem , Pelve/diagnóstico por imagem
18.
Rev Esp Med Nucl Imagen Mol ; 38(4): 218-223, 2019.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31133492

RESUMO

PURPOSE: To assess the feasibility of using freehand Single Photon Emission Computed Tomography (freehandSPECT) for the identification of technetium-99m-hydroxydiphosphonate (99mTc-HDP) positive bone lesions and to evaluate the possibility of using these imaging data-sets for augmented- and virtual-reality based navigation approaches. MATERIAL AND METHODS: In 20 consecutive patients referred for scintigraphy with 99mTc-HDP, 21 three-dimensional freehandSPECT-images were generated using a handheld gamma camera. Concordance of the two different data sets was ranked. Furthermore, feasibility of segmenting the hotspot of tracer accumulation for navigation purposes was assessed. RESULTS: In 86% of the cases freehandSPECT images showed good concordance with the corresponding part of the scintigraphic images. In lesions with a signal to background ratio (SBR) >1.36, freehandSPECT provided an automatically segmented reference point for navigation purposes. In 14% of the cases (average SBR 1.82, range 1.0-3.4) freehandSPECT images showed intermediate concordance due to difficult anatomical area or negative bone scintigraphy and could not be used as navigation targets. CONCLUSION: In this pilot study, in 86% of the cases freehandSPECT demonstrated good concordance with traditional scintigraphy. A lesion with a SBR of 1.36 or more was suitable for navigation. These high-quality freehandSPECT images supported the future exploration navigation strategies, e.g. guided needle biopsies.


Assuntos
Biópsia por Agulha/métodos , Doenças Ósseas/diagnóstico por imagem , Câmaras gama , Biópsia Guiada por Imagem/métodos , Medronato de Tecnécio Tc 99m/análogos & derivados , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Doenças Ósseas/patologia , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/secundário , Método Duplo-Cego , Desenho de Equipamento , Humanos , Biópsia Guiada por Imagem/instrumentação , Especificidade de Órgãos , Imagens de Fantasmas , Projetos Piloto , Compostos Radiofarmacêuticos/farmacocinética , Software , Medronato de Tecnécio Tc 99m/farmacocinética , Tomografia Computadorizada de Emissão de Fóton Único/instrumentação , Imagem Corporal Total
19.
J Therm Biol ; 82: 164-177, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31128644

RESUMO

Infrared thermal imaging (IRT) has been a target of research for biomedical musculoskeletal applications, due to the possible association of the physiological data that it provides, through skin temperature measurement, with pathological states. The aim of this systematic review is to acquaint the outcomes of the biomedical application of IRT in arm and forearm evaluation and its future perspectives of research. During the literature review, 926 articles were identified using the search engines PubMed and Scopus, and 10 articles were retrieved from other sources. After screening the abstracts and applying the eligibility criteria on those which were fully accessible, 33 articles were included in the review. It can be observed that IRT has the potential to provide physiological information on the arm and forearm, showing potential to serve as an aid in various pathologies and health situations. Future studies and challenges are identified and proposed, facilitating the improvement and acceptance of the application of IRT in the assessment of arm and forearm' health status.


Assuntos
Braço/diagnóstico por imagem , Antebraço/diagnóstico por imagem , Termografia/métodos , Braço/fisiologia , Doenças Ósseas/diagnóstico por imagem , Antebraço/fisiologia , Humanos , Raios Infravermelhos , Doenças Musculares/diagnóstico por imagem , Temperatura Cutânea
20.
World Neurosurg ; 128: 14-17, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31054339

RESUMO

BACKGROUND: An epidermoid cyst arising from diploic space in the skull can cause an intracranial mass effect with compression of the underlying venous sinuses. CASE DESCRIPTION: A 66-year-old woman came to us with a persistent headache and unsteadiness. Computed tomography demonstrated an occipital bone cystic lesion with an intracranial mass effect overlying the torcular herophili, with high-intensity findings in diffusion-weighted magnetic resonance imaging. Cerebral angiogram demonstrated obstruction of the torcular herophili with development of diploic venous drainage. The patient underwent removal of the lesion and a cranioplasty procedure. The diagnosis was torcular epidermoid cyst. The postoperative course was uneventful, and the symptoms were resolved. CONCLUSIONS: Development of diploic venous drainage contributed to avoidance of critical intracranial hypertension during slow growth of a torcular epidermoid cyst.


Assuntos
Doenças Ósseas/complicações , Transtornos Cerebrovasculares/etiologia , Cavidades Cranianas , Cisto Epidérmico/complicações , Idoso , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/patologia , Doenças Ósseas/cirurgia , Transtornos Cerebrovasculares/diagnóstico por imagem , Transtornos Cerebrovasculares/cirurgia , Constrição Patológica/diagnóstico por imagem , Constrição Patológica/etiologia , Constrição Patológica/cirurgia , Cavidades Cranianas/patologia , Cisto Epidérmico/diagnóstico por imagem , Cisto Epidérmico/patologia , Cisto Epidérmico/cirurgia , Feminino , Humanos , Hipertensão Intracraniana/etiologia , Osso Occipital
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA