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1.
Medicine (Baltimore) ; 100(16): e25297, 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33879660

RESUMO

ABSTRACT: To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center.Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of papillary lesions. The clinical, imaging, and pathological characteristics were reviewed.Patient cohort included 147 women diagnosed with papillary lesions (mean age at diagnosis 53.8 years) and were divided into 3 histology groups (benign, atypical, and malignant). Common clinical presentations were breast lump (n = 60) and nipple discharge (n = 29), 48 patients were asymptomatic.Only 37 were detected as a mass lesion on mammogram. The presence of mass lesion on mammogram was the most common feature in all 3 papillary lesion groups, and with the presence of asymmetric density, were the 2 mammographic features significantly associated (P < .05) with malignancy.All lesions were detected on ultrasound. The most common sonographic features for all 3 groups were the presence of a mass and irregular shape. Among all the sonographic features assessed, larger size, presence of vascularity and absence of dilated ducts were significantly associated (P < .05) with malignancy.Feature pattern recognition of the variety of benign, atypical and malignant papillary neoplasm on ultrasound and mammogram, with emphasis on size, presence of vascularity and dilated ducts on ultrasound and presence of mass, and architectural distortion on mammogram, is important in the assessment of patients with suspected ductal lesions to facilitate optimal treatment and surgical care.


Assuntos
Doenças Mamárias/diagnóstico , Neoplasias da Mama/diagnóstico , Mamografia/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Mama/diagnóstico por imagem , Mama/patologia , Doenças Mamárias/patologia , Neoplasias da Mama/patologia , Estudos Transversais , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Derrame Papilar/diagnóstico por imagem , Estudos Retrospectivos , Adulto Jovem
2.
Medicine (Baltimore) ; 100(12): e25166, 2021 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-33761692

RESUMO

RATIONALE: Pilonidal sinus disease (PSD) involving the breast is extremely rare and has not been described in man. PATIENT CONCERNS: This current case report presents a case of a pilonidal cyst in a 46-year-old man which was surgically treated. He had intermittent pain in his left breast for 2 months and came for local rupture and discharge for 1 week. DIAGNOSIS: The initial diagnosis is male mastitis, on the basis of the histological features of H&E-stained specimens and immunohistochemistry of the resected lump, this case was diagnosed as PSD. INTERVENTIONS: The patient underwent "enlarged resection of the left breast lesion" under local anesthesia. OUTCOMES: The patient's surgical area healed well, without any signs of recurrence. CONCLUSION: PSD involving the breast is extremely rare in man, with no typically clinical manifestations, and could be easily ignored. This disease requires great attentions from clinicians.


Assuntos
Doenças Mamárias/diagnóstico , Doenças Mamárias/cirurgia , Seio Pilonidal/diagnóstico , Seio Pilonidal/cirurgia , Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/patologia , Diagnóstico Diferencial , Humanos , Masculino , Mastite/diagnóstico , Pessoa de Meia-Idade , Seio Pilonidal/diagnóstico por imagem , Seio Pilonidal/patologia , Ultrassonografia
3.
Medicine (Baltimore) ; 100(13): e24875, 2021 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-33787577

RESUMO

BACKGROUND: In recent years, with the accelerated pace of life, diet, environmental problems occur frequently. External factors are easily to cause endocrine disorders and hormone sensitivity of breast tissue, which can lead to mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is increasing year by year, and the age of onset is also getting lower and lower. If not treated in time, there is a crisis of breast cancer.Clinical studies have found that auricular point pressing therapy is widely used in clinical treatment of mammary hyperplasia recently, but the efficacy of massage in the treatment of mammary hyperplasia has not been systematically reviewed. The purpose of this study is to explore the efficacy, safety and effectiveness of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. METHODS: We will search PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, Chinese Scientific Journal Database, CNKI, VIP, and Chinese Biomedical Literature Database. The retrieval date was January 10, 2021. RevMan 5.3 software was used to evaluate the quality and risk of included studies. The efficacy, recurrence rate, and symptom score of breast hyperplasia were analyzed, and the results were observed and measured. RESULTS: This study will be from the clinical efficiency, improvement rate, pain symptoms disappear rate, tumor size improvement rate, and other aspects of the existing evidence for a high quality synthesis, as well as auricular point pressing therapy adverse events. CONCLUSION: the conclusion of this review will provide the basis for judging whether auricular point pressing therapy is safe and effective in the treatment of hyperplasia of mammary glands. ETHICS AND DISSEMINATION: This systematic will evaluate the effectiveness and safety of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. As all data used in this systematic review and meta-analysis have been published, ethical approval is not required for this review. PROTOCOL REGISTRATION NUMBER: INPLASY202110028.


Assuntos
Pontos de Acupuntura , Doenças Mamárias/terapia , Glândulas Mamárias Humanas/patologia , Massagem/métodos , Doenças Mamárias/patologia , Ensaios Clínicos como Assunto , Pavilhão Auricular , Feminino , Humanos , Hiperplasia/terapia , Metanálise como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
4.
Br J Radiol ; 94(1120): 20201013, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33544650

RESUMO

Pathologic nipple discharge (PND) is typically unilateral, spontaneous, involves a single duct, and is serous or bloody in appearance. In patients with PND, breast MRI can be helpful as an additional diagnostic tool when conventional imaging with mammogram and ultrasound are negative. MRI is able to detect the etiology of nipple discharge in 56-61% of cases when initial imaging with mammogram and ultrasound are negative. Advantages to using MRI in evaluation of PND include good visualization of the retroareolar breast and better evaluation of posterior lesions which may not be well evaluated on mammograms and galactograms. It is also less invasive compared to central duct excision. Papillomas and nipple adenomas are benign breast masses that can cause PND and are well visualized on MRI. Ductal ectasia, and infectious etiologies such as mastitis, abscess, and fistulas are additional benign causes of PND that are well evaluated with MRI. MRI is also excellent for evaluation of malignant causes of PND including Paget's disease, ductal carcinoma in-situ and invasive carcinoma. MRI's high negative predictive value of 87-98.2% is helpful in excluding malignant etiologies of PND.


Assuntos
Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/patologia , Imagem por Ressonância Magnética/métodos , Derrame Papilar/diagnóstico por imagem , Feminino , Humanos , Mamilos/diagnóstico por imagem , Mamilos/patologia
5.
PLoS One ; 16(1): e0243983, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33395447

RESUMO

Several gene expression studies have been previously conducted to characterize molecular basis of Wooden Breast myopathy in commercial broiler chickens. These studies have generally used a limited sample size and relied on a binary disease outcome (unaffected or affected by Wooden Breast), which are appropriate for an initial investigation. However, to identify biomarkers of disease severity and development, it is necessary to use a large number of samples with a varying degree of disease severity. Therefore, in this study, we assayed a relatively large number of samples (n = 96) harvested from the pectoralis major muscle of unaffected (U), partially affected (P) and markedly affected (A) chickens. Gene expression analysis was conducted using the nCounter MAX Analysis System and data were analyzed using four different supervised machine-learning methods, including support vector machines (SVM), random forests (RF), elastic net logistic regression (ENET) and Lasso logistic regression (LASSO). The SVM method achieved the highest prediction accuracy for both three-class (U, P and A) and two-class (U and P+A) classifications with 94% prediction accuracy for two-class classification and 85% for three-class classification. The results also identified biomarkers of Wooden Breast severity and development. Additionally, gene expression analysis and ultrastructural evaluations provided evidence of vascular endothelial cell dysfunction in the early pathogenesis of Wooden Breast.


Assuntos
Doenças Mamárias/patologia , Endotélio Vascular/fisiopatologia , Regulação da Expressão Gênica , Doenças das Aves Domésticas/patologia , Aprendizado de Máquina Supervisionado , Animais , Biomarcadores/metabolismo , Doenças Mamárias/genética , Doenças Mamárias/metabolismo , Galinhas , Endotélio Vascular/citologia , Endotélio Vascular/ultraestrutura , Metabolismo dos Lipídeos/genética , Lipase Lipoproteica/genética , Modelos Logísticos , Microscopia Eletrônica de Transmissão , Contração Muscular/fisiologia , Músculos Peitorais/metabolismo , Músculos Peitorais/ultraestrutura , Doenças das Aves Domésticas/genética , Doenças das Aves Domésticas/metabolismo
6.
J Pediatr Adolesc Gynecol ; 34(2): 209-212, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33338626

RESUMO

BACKGROUND: Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast lesion that is is extremely rare in children and adolescents. CASE: A 13-year-old girl was admitted to our clinic with a giant mass in the left breast for 3 months. Physical examination findings of the patient were normal except for the mass in the breast. The mass was removed totally, and its pathological diagnosis was pseudoangiomatous stromal hyperplasia. The patient has been followed up for 6 months without disease.


Assuntos
Angiomatose/patologia , Doenças Mamárias/patologia , Hiperplasia/patologia , Adolescente , Mama/patologia , Feminino , Humanos , Ilustração Médica
7.
Rev. senol. patol. mamar. (Ed. impr.) ; 33(4): 151-156, oct.-dic. 2020. ilus
Artigo em Inglês | IBECS | ID: ibc-201068

RESUMO

Female transgender (male to female) is an individual assigned male sex at birth born but who identifies itself and desires to live as female. To achieve and maintain these characteristics, sometimes, it is necessary to undergo hormone therapy and/or surgical treatment. Benign lesions have been described including: fibroadenoma, lobular hyperplasia, pseudoangiomatous stromal hyperplasia, myofibroblastoma, angiolipoma and benign prosthesic reactions. And malignant pathology such as: ductal carcinoma in situ, Paget's disease, infiltrating carcinoma of non-special type (ductal, NOS), secretory adenocarcinoma, malignant phyllodes tumor and breast implant associated anaplastic large cell lymphoma. The described cases of each of these entities are reviewed. In conclusion, hormonal action or prosthesis implantation in female transgender can lead to associated pathologies in the mammary gland that follow a similar pattern to that found in the male breast. Although breast cancer is less frequent than in cisgender women, gynecological control or screening is recommended by some associations


La mujer transgénero (hombre a mujer) es aquella persona nacida varón pero que se identifica y desea vivir como una mujer. Para lograr este objetivo muchas veces precisa de tratamiento hormonal o quirúrgico para alcanzar los atributos sexuales de una mujer. La patología mamaria que estos pacientes pueden presentar es superponible a la patología de la mama masculina, a la patología derivada del tratamiento hormonal y a la relacionada con los implantes mamarios sintéticos. Se han descrito lesiones benignas que incluyen: fibroadenoma, hiperplasia lobulillar, hiperplasia estromal seudoangiomatosa, miofibroblastoma, angiolipoma y reacciones benignas a la prótesis. Y patología maligna como: carcinoma ductal in situ, enfermedad de Paget, carcinoma infiltrante de tipo no especial (ductal, NOS), adenocarcinoma secretor, tumor filoides maligno y linfoma anaplásico de célula grande asociado a prótesis. Se revisan los casos descritos de cada una de estas entidades. En conclusión, la acción hormonal o la implantación de prótesis en las mujeres transgénero pueden llevar asociadas patologías en la glándula mamaria que siguen un patrón similar al de la patología encontrada en la mama del varón. Aunque el cáncer de mama es menos frecuente que en las mujeres cisgénicas, se recomienda un control ginecológico o mediante cribado igual al de estas


Assuntos
Humanos , Feminino , Transexualidade , Doenças Mamárias/patologia , Neoplasias da Mama/patologia , Pessoas Transgênero/estatística & dados numéricos , Procedimentos de Readequação Sexual/estatística & dados numéricos , Implantes de Mama/estatística & dados numéricos , Estrogênios/farmacocinética
8.
Adv Exp Med Biol ; 1252: 9-16, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32816257

RESUMO

Physical exam of the breast is a very important part of breast assessment both for breast cancer screening, and when approaching breast lesions. Examination during pregnancy and breastfeeding follows exactly the same method as non-pregnancy periods. However, physical changes that occur in the breast during these times due to hormonal effects cause alterations that can on one hand conceal some pathologic disorders, and may on the other hand appear as pathologic findings while being purely physiologic. This chapter focuses first on some key points for an accurate breast examination, and then reviews some challenging controversial findings that may be noticed during breast exam in a pregnant or lactating woman.


Assuntos
Doenças Mamárias/diagnóstico , Mama/anatomia & histologia , Mama/patologia , Lactação/fisiologia , Exame Físico , Mama/fisiologia , Doenças Mamárias/patologia , Aleitamento Materno , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Feminino , Humanos , Gravidez
9.
Adv Exp Med Biol ; 1252: 27-32, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32816259

RESUMO

Breast tissue reveals some physiologic changes during pregnancy and lactation due to hormonal alterations. Whole range of breast diseases including inflammatory, benign and malignant neoplasms can be seen in pregnancy but due to concurrent physiologic changes, may lead to diagnostic challenges. This chapter reviews sampling methods and histologic features of common benign breast lesions in pregnancy and lactation periods.


Assuntos
Doenças Mamárias/patologia , Mama/citologia , Mama/patologia , Lactação/fisiologia , Complicações na Gravidez , Gravidez/fisiologia , Neoplasias da Mama/patologia , Feminino , Humanos
10.
Adv Exp Med Biol ; 1252: 33-39, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32816260

RESUMO

The breast tissue undergoes significant physiological change during pregnancy and lactation. These changes can give rise to some unique disorders during pregnancy , puerperium and lactation or exaggerate pre-existing conditions. Clinical examination becomes less reliable due to textural change and density of breast tissue as a result of hormonal changes. The main symptoms during pregnancy and lactation are breast pain, mastitis, lactational abscess, breast lump, and blood- stained nipple discharge.Lactational mastitis/ abscess must be treated without delay. Open incision and drainage of lactational abscess is rarely required, any lactational abscess should be treated with appropriate antibiotics and ultrasound guided aspiration of the pus.Any breast lump during pregnancy and lactation should be investigated with triple assessment. Pregnancy associated breast cancer (PABC ) must be ruled out. The choice of investigations and treatment needs careful consideration. While ultrasound is the investigation of choice, mammography can be performed with abdominal shielding if malignancy is suspected. Core biopsy is necessary for evaluation of any breast pathology but it comes with risk of infection, bleeding, hematoma and even milk fistula.The treating clinical specialist must be aware of certain unusual unique clinical conditions in pregnancy and lactation including accessory axillary breast tissue, gigantomastia and Raynaud's phenomenon.


Assuntos
Doenças Mamárias/diagnóstico , Doenças Mamárias/fisiopatologia , Lactação , Complicações na Gravidez , Abscesso , Mama , Doenças Mamárias/patologia , Aleitamento Materno , Feminino , Humanos , Mastite , Gravidez
11.
Medicine (Baltimore) ; 99(27): e21063, 2020 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-32629735

RESUMO

BACKGROUND: Overflow breast disease (OBD), also known as breast nipple discharge, refers fluid or liquid that comes out of nipple. Many patients with breast cancer experience such condition. However, it is not easy to detect it at early stage, especially for pathological OBD. Previous study found low-dose CT combined mammography (LDCTMG) could help in diagnosis of OBD. However, there is no systematic review investigating this issue. Therefore, this study will examine the accuracy of LDCTMG in diagnosis of OBD. METHODS: This study protocol will search literature sources in electronic databases and other sources. The electronic databases will be retrieved in The Cochrane Library, the Cochrane Register of Diagnostic Test Accuracy Studies, PUBMED, EMBASE, Web of Science, CINAHL, CNKI, and WANGFANG from inception to the present. We will also search other sources. All literature sources will be sought without restrictions to the language and publication status. Two researchers will independently carry out study selection, data extraction, and study quality assessment. Statistical analysis will be performed using RevMan 5.3. RESULTS: This study will exert a high-quality synthesis of eligible studies on the analysis of LDCTMG in diagnosis of OBD. CONCLUSIONS: The results of this study may provide evidence to help judge whether LDCTMG is accurate in diagnosis of OBD. STUDY REGISTRATION: INPLASY202050116.


Assuntos
Doenças Mamárias/diagnóstico por imagem , Mamografia/métodos , Derrame Papilar/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adulto , Doenças Mamárias/epidemiologia , Doenças Mamárias/patologia , Estudos de Avaliação como Assunto , Feminino , Humanos , Imagem Multimodal/métodos
13.
Niger J Clin Pract ; 23(5): 744-746, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32367886

RESUMO

Multiple symmetric lipomatosis (MSL) is a very uncommon disease. Its etiopathogenesis is uncertain, although it has been linked to a variety of factors. Its main characteristic is the overgrowth of fat in form of an unencapsulated lesion. Most of the cases reported are in the head and neck region. We report a case that occurred in the breasts of a 62-year-old man. A clinical diagnosis of gynecomastia was initially made. Partial mastectomy was done and MSL was reported on histopathologic examination. Our literature search revealed no previous case of MSL in the breast reported from our environment.


Assuntos
Doenças Mamárias , Lipomatose Simétrica Múltipla , Doenças Mamárias/diagnóstico , Doenças Mamárias/patologia , Doenças Mamárias/cirurgia , Diagnóstico Diferencial , Humanos , Lipomatose Simétrica Múltipla/diagnóstico , Lipomatose Simétrica Múltipla/patologia , Lipomatose Simétrica Múltipla/cirurgia , Masculino , Mastectomia , Pessoa de Meia-Idade
14.
Anticancer Res ; 40(4): 2185-2190, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32234913

RESUMO

BACKGROUND/AIM: The study aimed at investigating the correlation between ductoscopic and histopathological findings and clarify whether the former allow for accurate prediction of malignancy. PATIENTS AND METHODS: The prospective national multi-center study covered a sample of 224 patients with pathologic nipple discharge. A total of 214 patients underwent ductoscopy with subsequent extirpation of the mammary duct. The ductoscopic findings were categorized according to shape, number, color and surface structure of lesions and vascularity and compared to the histological results and analyses. RESULTS: Ductoscopy revealed lesions in 134 of 214 patients (62.2%). The criteria "multiple versus solitary lesion" differed significantly between malignant and benign lesions. All other criteria were not statistically significant. Malignant tumors were more frequently presented as multiple lesions, benign lesions or masses as solitary lesions (80% vs. 24.8%; p=0.018). CONCLUSION: The ductoscopic criterion "solitary vs. multiple lesion" appears to have a low diagnostic prediction of malignancy or benignity.


Assuntos
Doenças Mamárias/diagnóstico , Neoplasias da Mama/diagnóstico , Carcinoma Intraductal não Infiltrante/diagnóstico , Endoscopia/métodos , Derrame Papilar , Mamilos/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doenças Mamárias/metabolismo , Doenças Mamárias/patologia , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Carcinoma Intraductal não Infiltrante/metabolismo , Carcinoma Intraductal não Infiltrante/patologia , Diagnóstico Diferencial , Feminino , Alemanha , Humanos , Pessoa de Meia-Idade , Mamilos/metabolismo , Estudos Prospectivos , Adulto Jovem
16.
Br J Radiol ; 93(1110): 20190932, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32216631

RESUMO

OBJECTIVE: This study aimed to compare the diagnostic performance of contrast-enhanced ultrasound (CEUS), MRI, and the combined use of the two modalities for differentiating breast lesions of different sizes. METHODS: A total of 406 patients with 406 solid breast masses detected by conventional ultrasound underwent both CEUS and MRI scans. Histological results were used as reference standards. The lesions were categorized into three groups according to size (Group 1, ≤ 20 mm; Group 2, > 20 mm, Group 3: total lesions). Sensitivity, specificity, accuracy, and receiver operating characteristic (ROC) curve analysis were used to assess the diagnostic performance of these imaging methods for breast lesions. RESULTS: There were 194 benign and 212 malignant breast lesions according to the histological diagnosis. Compared with MRI, CEUS demonstrated similar sensitivity in detecting breast cancer (p = 1.0000 for all) in all the three groups. With regard to specificity, accuracy, and the area under the ROC curve (Az) values, MRI showed a better performance than that shown by CEUS (p <0.05 for all), and the combination of the two modalities improved the diagnostic performance of CEUS alone significantly (p <0.05 for all) in all the three groups. However, the diagnostic specificity and accuracy of the combined method was not superior to that of MRI alone except for Group 2. CONCLUSION: CEUS demonstrated good sensitivity in detecting breast cancer, and the combined use with MRI can optimize the diagnostic specificity and accuracy in breast cancer prediction. ADVANCES IN KNOWLEDGE: Few studies have compared the diagnostic efficacy of CEUS and MRI, and this study is the first attempt to seek out the diagnostic values for breast lesions of variable sizes (lesions with ≤20 mm and >20 mm).


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Meios de Contraste , Imagem por Ressonância Magnética/métodos , Ultrassonografia Mamária/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Doenças Mamárias/diagnóstico por imagem , Doenças Mamárias/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Imagem Multimodal/métodos , Curva ROC , Estudos Retrospectivos , Sensibilidade e Especificidade , Carga Tumoral , Adulto Jovem
17.
Rev. esp. patol ; 53(1): 42-47, ene.-mar. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-195575

RESUMO

La mucinosis nodular de la mama es una rara entidad de histogénesis incierta y con comportamiento benigno. Suele presentarse como una tumoración asintomática en torno a pezón o areola y localizada en dermis o tejido celular subcutáneo. Presentamos un caso de mucinosis nodular típica. Histológicamente se define por estar constituida por lagos irregulares de mucina negativos con PAS pero positivos con hierro coloidal y azul alcián. La mucina se acompaña de estroma fibroso con un escaso componente de células fusiformes. Algunos autores sugieren un posible origen miofibroblástico. No obstante no se han realizado estudios moleculares de la mucinosis nodular. El diagnóstico diferencial se ha de hacer principalmente con lesiones mamarias benignas y malignas de estroma mucinoso. En la literatura se describen 13 casos de mucinosis nodular


Nodular mucinosis of the breast is a rare entity of uncertain histogenesis and with benign behavior. It usually presents as an asymptomatic tumor around the nipple or areola and located in the dermis or subcutaneous cellular tissue. We present a case of typical nodular mucinosis. Histologically it is defined as being composed of irregular lakes of mucin negative with PAS but positive with colloidal iron and alcian blue. Mucin is accompanied by fibrous stroma with a scarce component of fusiform cells. Some authors suggest a possible myofibroblastic origin. However, molecular studies of nodular mucinosis have not been performed. The differential diagnosis must be made mainly with benign and malignant mammary lesions of mucinous stroma. In the literature, 13 cases of nodular mucinosis are described


Assuntos
Humanos , Feminino , Adulto , Doenças Mamárias/patologia , Mucinoses/patologia
18.
Cancer Res ; 80(8): 1762-1772, 2020 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-32094303

RESUMO

Breast microcalcifications are a common mammographic finding. Microcalcifications are considered suspicious signs of breast cancer and a breast biopsy is required, however, cancer is diagnosed in only a few patients. Reducing unnecessary biopsies and rapid characterization of breast microcalcifications are unmet clinical needs. In this study, 473 microcalcifications detected on breast biopsy specimens from 56 patients were characterized entirely by Raman mapping and confirmed by X-ray scattering. Microcalcifications from malignant samples were generally more homogeneous, more crystalline, and characterized by a less substituted crystal lattice compared with benign samples. There were significant differences in Raman features corresponding to the phosphate and carbonate bands between the benign and malignant groups. In addition to the heterogeneous composition, the presence of whitlockite specifically emerged as marker of benignity in benign microcalcifications. The whole Raman signature of each microcalcification was then used to build a classification model that distinguishes microcalcifications according to their overall biochemical composition. After validation, microcalcifications found in benign and malignant samples were correctly recognized with 93.5% sensitivity and 80.6% specificity. Finally, microcalcifications identified in malignant biopsies, but located outside the lesion, reported malignant features in 65% of in situ and 98% of invasive cancer cases, respectively, suggesting that the local microenvironment influences microcalcification features. This study confirms that the composition and structural features of microcalcifications correlate with breast pathology and indicates new diagnostic potentialities based on microcalcifications assessment. SIGNIFICANCE: Raman spectroscopy could be a quick and accurate diagnostic tool to precisely characterize and distinguish benign from malignant breast microcalcifications detected on mammography.


Assuntos
Doenças Mamárias/metabolismo , Doenças Mamárias/patologia , Mama/patologia , Calcinose/metabolismo , Calcinose/patologia , Análise Espectral Raman/métodos , Biomarcadores/análise , Biópsia , Mama/química , Carcinoma de Mama in situ/química , Carcinoma de Mama in situ/diagnóstico , Carcinoma de Mama in situ/patologia , Doenças Mamárias/diagnóstico , Neoplasias da Mama/química , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Calcinose/diagnóstico , Fosfatos de Cálcio/análise , Carbonatos/análise , Feminino , Humanos , Fosfatos/análise , Sensibilidade e Especificidade
19.
J Clin Ultrasound ; 48(3): 168-173, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32003472

RESUMO

We describe the case of a 41-year-old woman with primary Sjögren's syndrome (SS) who presented multiple recurrences of breast amyloidosis. Each recurrence of breast amyloidosis showed different sonographic features, potentially mimicking malignancy. We briefly discuss the possible cause of this variability in imaging features based on the radiologic-histologic correlation.


Assuntos
Amiloidose/complicações , Amiloidose/diagnóstico por imagem , Doenças Mamárias/complicações , Doenças Mamárias/diagnóstico por imagem , Síndrome de Sjogren/complicações , Adulto , Amiloidose/patologia , Amiloidose/cirurgia , Doenças Mamárias/patologia , Doenças Mamárias/cirurgia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Recidiva , Ultrassonografia/métodos
20.
Mymensingh Med J ; 29(1): 48-54, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31915335

RESUMO

One-fourth of all women suffer from breast disease in their lifetime. World Health Organization estimated that over 508,000 women died in 2011 due to breast cancer worldwide.For several years, fine needle aspiration cytology (FNAC) was the most practiced method for the pathological diagnosis of breast lump specially differentiation of benign from malignant. The advent of core needle or True-Cut biopsy (TCB) in the new millennium has resulted in many surgeons switching to TCB since it provides a sufficient amount of tissue for pathologists to make an accurate histological diagnosis.During the study period, patients present with clinically palpable breast lump admitted in different surgicalunits of MMCH, among them 100 patients selected purposively. Then a prospective comparative study was carried out in the Department of Surgery, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from September 2017 to February 2018. Out of a total of 100 patients, who presented with suspicious breast lump, as clinically diagnosed 68 patients had benign breast lump and 32 patients had malignant breast lump. FNAC confirmed the diagnosis of breast carcinoma in 27 patients with sensitivity 89.65% and specificity 66.66%. True-cut biopsy confirmed the diagnosis of breast carcinoma in 29 patients with sensitivity 96.66% and specificity 100%. It also gave the definitive histological type and grade which correlated with the final histopathology report in 29 out of the 30 patientsTCB also provides adequate tissue for the evaluation of molecular markers which have extreme therapeutic value.


Assuntos
Biópsia por Agulha/métodos , Biópsia/métodos , Doenças Mamárias/patologia , Neoplasias da Mama/patologia , Mama/patologia , Carcinoma/patologia , Adulto , Bangladesh/epidemiologia , Biópsia por Agulha Fina , Neoplasias da Mama/epidemiologia , Carcinoma/epidemiologia , Feminino , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade
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