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1.
J Laryngol Otol ; 134(6): 558-561, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32618525

RESUMO

BACKGROUND: Pyriform aperture stenosis is a rare form of congenital nasal obstruction; it poses a management dilemma for otolaryngologists and physicians alike. It can result in poor weight gain and potentially life-threatening airflow obstruction. The challenge lies in the difficulty to predict which patients will require invasive operative management versus conservative therapy alone. CASE REPORT: This case demonstrates the successful use of high-flow nasal cannula therapy in a young child with pyriform aperture stenosis.


Assuntos
Cânula/efeitos adversos , Constrição Patológica/terapia , Obstrução Nasal/congênito , Doenças Nasais/congênito , Assistência ao Convalescente , Cânula/estatística & dados numéricos , Criança , Tratamento Conservador/métodos , Constrição Patológica/etiologia , Humanos , Masculino , Obstrução Nasal/diagnóstico por imagem , Obstrução Nasal/patologia , Doenças Nasais/complicações , Doenças Nasais/patologia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
2.
Rev. bras. cir. plást ; 35(2): 254-257, apr.-jun. 2020. ilus
Artigo em Inglês, Português | LILACS | ID: biblio-1103842

RESUMO

Hemangioma infantil (HI) é o tumor vascular mais comum e a neoplasia benigna mais frequente da infância, com maior incidência no sexo feminino e na população branca. Quase 60% dos casos ocorrem em cabeça e pescoço, sendo o tratamento ativo durante a fase proliferativa mais frequentemente indicado, em decorrência dos possíveis problemas funcionais e do potencial desfigurante. Relatamos um caso de paciente com hemangioma infantil involuído de ponta nasal e lábio superior, tratado de forma expectante durante a infância, submetida à correção da deformidade residual com técnicas de rinoplastia, associado à zetaplastia e lipoenxertia do lábio superior com bom resultado e satisfação do paciente.


Infantile hemangioma (IH) is the most common vascular tumor and the most frequent benign neoplasm in childhood, with the highest incidence in females and the white population. Almost 60% of cases occur in the head and neck, and active treatment during the proliferative phase is the most frequently indicated, due to possible functional problems and disfiguring potential. We report a case of a patient with involute infantile hemangioma of the nasal tip and upper lip, treated expectantly during childhood, submitted to residual deformity correction with rhinoplasty techniques, associated with zetaplasty and upper lip grafting with good results and patient satisfaction.


Assuntos
Humanos , Feminino , Adulto , História do Século XXI , Rinoplastia , Ferimentos e Lesões , Relatos de Casos , Nariz , Doenças Nasais , Neoplasias Vasculares , Hemangioma , Lábio , Rinoplastia/efeitos adversos , Rinoplastia/métodos , Ferimentos e Lesões/cirurgia , Nariz/cirurgia , Nariz/patologia , Doenças Nasais/cirurgia , Doenças Nasais/patologia , Neoplasias Vasculares/cirurgia , Neoplasias Vasculares/patologia , Hemangioma/cirurgia , Hemangioma/patologia , Lábio/cirurgia , Lábio/patologia
3.
Rhinology ; 58(3): 289-294, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: covidwho-342762

RESUMO

On March 11th 2020, the World Health Organization (WHO) declared COVID-19 pandemic, with subsequent profound impact on the entire health care system. During the COVID-19 outbreak, activities in the rhinology outpatient clinic and operation rooms are limited to emergency care only. Health care practitioners are faced with the need to perform rhinological and skull base emergency procedures in patients with a positive or unknown COVID-19 status. This article aims to provide recommendations and relevant information for rhinologists, based on the limited amount of (anecdotal) data, to guarantee high-quality patient care and adequate levels of infection prevention in the rhinology clinic.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Endoscopia , Doenças Nasais , Pandemias , Equipamento de Proteção Individual , Pneumonia Viral , Base do Crânio , Infecções por Coronavirus/epidemiologia , Endoscopia/métodos , Humanos , Controle de Infecções , Doenças Nasais/cirurgia , Pneumonia Viral/epidemiologia , Base do Crânio/cirurgia
4.
Otolaryngol Head Neck Surg ; 163(1): 145-150, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32423283

RESUMO

OBJECTIVE: The primary mode of viral transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to occur through the spread of respiratory droplets. The objective of this study was to investigate droplet and splatter patterns resulting from common endoscopic endonasal procedures. STUDY DESIGN: Cadaver simulation series. SETTING: Dedicated surgical laboratory. SUBJECTS AND METHODS: After instilling cadaver head specimens (n = 2) with fluorescein solution, endoscopic endonasal procedures were systematically performed to evaluate the quantity, size, and distance of droplets and splatter following each experimental condition. RESULTS: There were no observable fluorescein droplets or splatter noted in the measured surgical field in any direction after nasal endoscopy, septoplasty with microdebrider-assisted turbinoplasty, cold-steel functional endoscopic sinus surgery (FESS), and all experimental conditions using an ultrasonic aspirator. Limited droplet spread was noted with microdebrider FESS (2 droplets, <1 mm in size, within 10 cm), drilling of the sphenoid rostrum with a diamond burr (8, <1 mm, 12 cm), and drilling of the frontal beak with a cutting burr (5, <1 mm, 9 cm); however, the use of concurrent suction while drilling resulted in no droplets or splatter. The control condition of external activation of the drill resulted in gross contamination (11, 2 cm, 13 cm). CONCLUSION: Our results indicate that there is very little droplet generation from routine rhinologic procedures. The droplet generation from drilling was mitigated with the use of concurrent suction. Extreme caution should be used to avoid activating powered instrumentation outside of the nasal cavity, which was found to cause droplet contamination.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Transmissão de Doença Infecciosa/prevenção & controle , Endoscopia/métodos , Doenças Nasais/cirurgia , Pneumonia Viral/complicações , Rinoplastia/métodos , Treinamento por Simulação/métodos , Cadáver , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/transmissão , Humanos , Doenças Nasais/complicações , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/transmissão , Resultado do Tratamento
6.
J Laryngol Otol ; 134(5): 440-446, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32431257

RESUMO

BACKGROUND: Levamisole is an increasingly common cutting agent used with cocaine. Both cocaine and levamisole can have local and systemic effects on patients. METHODS: A retrospective case series was conducted of patients with a cocaine-induced midline destructive lesion or levamisole-induced vasculitis, who presented to a Dundee hospital or the practice of a single surgeon in Paisley, from April 2016 to April 2019. A literature review on the topic was also carried out. RESULTS: Nine patients from the two centres were identified. One patient appeared to have levamisole-induced vasculitis, with raised proteinase 3, perinuclear antineutrophil cytoplasmic antibodies positivity and arthralgia which improved on systemic steroids. The other eight patients had features of a cocaine-induced midline destructive lesion. CONCLUSION: As the use of cocaine increases, ENT surgeons will see more of the complications associated with it. This paper highlights some of the diagnostic issues and proposes a management strategy as a guide to this complex patient group. Often, multidisciplinary management is needed.


Assuntos
Cocaína/efeitos adversos , Inibidores da Captação de Dopamina/efeitos adversos , Levamisol/efeitos adversos , Antagonistas Nicotínicos/efeitos adversos , Doenças Nasais/induzido quimicamente , Transtornos Relacionados ao Uso de Substâncias/complicações , Vasculite/induzido quimicamente , Adulto , Transtornos Relacionados ao Uso de Cocaína/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Perfuração do Septo Nasal/induzido quimicamente , Estudos Retrospectivos
7.
Rhinology ; 58(3): 289-294, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32441710

RESUMO

On March 11th 2020, the World Health Organization (WHO) declared COVID-19 pandemic, with subsequent profound impact on the entire health care system. During the COVID-19 outbreak, activities in the rhinology outpatient clinic and operation rooms are limited to emergency care only. Health care practitioners are faced with the need to perform rhinological and skull base emergency procedures in patients with a positive or unknown COVID-19 status. This article aims to provide recommendations and relevant information for rhinologists, based on the limited amount of (anecdotal) data, to guarantee high-quality patient care and adequate levels of infection prevention in the rhinology clinic.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Endoscopia , Doenças Nasais , Pandemias , Equipamento de Proteção Individual , Pneumonia Viral , Base do Crânio , Infecções por Coronavirus/epidemiologia , Endoscopia/métodos , Humanos , Controle de Infecções , Doenças Nasais/cirurgia , Pneumonia Viral/epidemiologia , Base do Crânio/cirurgia
9.
Niger J Clin Pract ; 23(4): 464-469, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32246651

RESUMO

Background: Paradoxical curvature of the middle nasal turbinate (MT) is a common anatomic variant, usually found and reported on coronal CT slices. However, less attention has been paid to the sagittal groove (SG) which is determining it. Aim: The study aimed to determine paradoxical curvatures and bifidities in the sagittal groves of middle nasal turbinate. Material and Method: A retrospective CBCT study on the archived files of 52 adult patients was performed. Results: Different patterns of MT bifidity were found: (1) unilateral bifid MTs; (2) bifid and trifid MTs and "wandering" single SGs; (3) bilateral bifid middle turbinates and double SGs, (4) bilateral false bifid appearance due to middle and superior turbinates fusion and (5) bifid concha bullosa media. Digital "dissections" of patients' files allowed us to conclude that paradoxical curvature as well as bifidity of MTs relate to the placement and number of the SGs on the MTs. Such SGs were previously documented in prenatal MTs since the 14th week, as well as in pædiatric patients. Conclusions: It seems reasonable to speculate that paradoxical curvature, as well as bifidity of MT, this later being previously undocumented, are just adult vestiges of the primitive MT morphology. Nevertheless, documentation of the MT morphology should not rely exclusively on coronal CTs, as combined morphologies of that turbinate could occur.


Assuntos
Tomografia Computadorizada por Raios X/métodos , Conchas Nasais/anatomia & histologia , Conchas Nasais/diagnóstico por imagem , Adulto , Variação Anatômica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Nasais/diagnóstico por imagem , Estudos Retrospectivos
10.
Int Forum Allergy Rhinol ; 10(7): 798-805, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32243678

RESUMO

BACKGROUND: International experience with coronavirus 2019 (COVID-19) suggests it poses a significant risk of infectious transmission to skull base surgeons, due to high nasal viral titers and the unknown potential for aerosol generation during endonasal instrumentation. The purpose of this study was to simulate aerosolization events over a range of endoscopic procedures to obtain an evidence-based aerosol risk assessment. METHODS: Aerosolization was simulated in a cadaver using fluorescein solution (0.2 mg per 10 mL) and quantified using a blue-light filter and digital image processing. Outpatient sneezing during endoscopy was simulated using an intranasal atomizer in the presence or absence of intact and modified surgical mask barriers. Surgical aerosolization was simulated during nonpowered instrumentation, suction microdebrider, and high-speed drilling after nasal fluorescein application. RESULTS: Among the outpatient conditions, a simulated sneeze event generated maximal aerosol distribution at 30 cm, extending to 66 cm. Both an intact surgical mask and a modified VENT mask (which enables endoscopy) eliminated all detectable aerosol spread. Among the surgical conditions, cold instrumentation and microdebrider use did not generate detectable aerosols. Conversely, use of a high-speed drill produced significant aerosol contamination in all conditions tested. CONCLUSION: We confirm that aerosolization presents a risk to the endonasal skull base surgeon. In the outpatient setting, use of a barrier significantly reduces aerosol spread. Cold surgical instrumentation and microdebrider use pose significantly less aerosolization risk than a high-speed drill. Procedures requiring drill use should carry a special designation as an "aerosol-generating surgery" to convey this unique risk, and this supports the need for protective personal protective equipment.


Assuntos
Infecções por Coronavirus/transmissão , Endoscopia/efeitos adversos , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Doenças Nasais , Otolaringologia/normas , Pneumonia Viral/transmissão , Aerossóis , Betacoronavirus/isolamento & purificação , Cadáver , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/prevenção & controle , Endoscopia/instrumentação , Humanos , Doenças Nasais/diagnóstico , Doenças Nasais/cirurgia , Doenças Nasais/virologia , Otolaringologia/instrumentação , Pandemias/prevenção & controle , Equipamento de Proteção Individual/virologia , Pneumonia Viral/epidemiologia , Pneumonia Viral/prevenção & controle , Espirro
12.
J Laryngol Otol ; 134(4): 328-331, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32234081

RESUMO

OBJECTIVE: Convolutional neural networks are a subclass of deep learning or artificial intelligence that are predominantly used for image analysis and classification. This proof-of-concept study attempts to train a convolutional neural network algorithm that can reliably determine if the middle turbinate is pneumatised (concha bullosa) on coronal sinus computed tomography images. METHOD: Consecutive high-resolution computed tomography scans of the paranasal sinuses were retrospectively collected between January 2016 and December 2018 at a tertiary rhinology hospital in Australia. The classification layer of Inception-V3 was retrained in Python using a transfer learning method to interpret the computed tomography images. Segmentation analysis was also performed in an attempt to increase diagnostic accuracy. RESULTS: The trained convolutional neural network was found to have diagnostic accuracy of 81 per cent (95 per cent confidence interval: 73.0-89.0 per cent) with an area under the curve of 0.93. CONCLUSION: A trained convolutional neural network algorithm appears to successfully identify pneumatisation of the middle turbinate with high accuracy. Further studies can be pursued to test its ability in other clinically important anatomical variants in otolaryngology and rhinology.


Assuntos
Inteligência Artificial/normas , Doenças Nasais/etiologia , Seios Paranasais/diagnóstico por imagem , Tomografia Computadorizada por Raios X/instrumentação , Conchas Nasais/diagnóstico por imagem , Algoritmos , Austrália/epidemiologia , Feminino , Humanos , Masculino , Redes Neurais de Computação , Doenças Nasais/diagnóstico por imagem , Doenças Nasais/patologia , Doenças Nasais/cirurgia , Variações Dependentes do Observador , Estudos Retrospectivos , Conchas Nasais/patologia , Conchas Nasais/cirurgia
13.
PLoS One ; 15(3): e0225901, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32119674

RESUMO

Hereditary nasal parakeratosis (HNPK) is an inherited disorder described in Labrador Retrievers and Greyhounds. It has been associated with breed-specific variants in the SUV39H2 gene encoding a histone 3 methyltransferase involved in epigenetic silencing. Formalin-fixed biopsies of the nasal planum of Labrador Retrievers were screened by immunofluorescence microscopy for the presence and distribution of epidermal proliferation and differentiation markers. Gene expression of these markers was further analysed using RNA sequencing (RNA-seq) and ultrastructural epidermal differences were investigated by electron microscopy. Differentiation of the nasal planum in the basal and suprabasal epidermal layers of HNPK-affected dogs (n = 6) was similar compared to control dogs (n = 6). In the upper epidermal layers, clear modifications were noticed. Loricrin protein was absent in HNPK-affected nasal planum sections in contrast to sections of the same location of control dogs. However, loricrin was present in the epidermis of paw pads and abdominal skin from HNPK dogs and healthy control dogs. The patterns of keratins K1, K10 and K14, were not markedly altered in the nasal planum of HNPK-affected dogs while the expression of the terminal differentiation marker involucrin appeared less regular. Based on RNA-seq, LOR and IVL expression levels were significantly decreased, while KRT1, KRT10 and KRT14 levels were up-regulated (log2fold-changes of 2.67, 3.19 and 1.71, respectively) in HNPK-affected nasal planum (n = 3) compared to control dogs (n = 3). Electron microscopical analysis revealed structural alterations in keratinocytes and stratum corneum, and disrupted keratinocyte adhesions and distended intercellular spaces in lesional samples (n = 3) compared to a sample of a healthy control dog (n = 1). Our findings demonstrate aberrant keratinocyte terminal differentiation of the nasal planum of HNPK-affected Labrador Retrievers and provide insights into biological consequences of this inactive SUV39H2 gene variant.


Assuntos
Antígenos de Diferenciação , Doenças do Cão , Doenças Genéticas Inatas , Doenças Nasais , Paraceratose , Animais , Antígenos de Diferenciação/genética , Antígenos de Diferenciação/metabolismo , Doenças do Cão/genética , Doenças do Cão/metabolismo , Doenças do Cão/patologia , Cães , Feminino , Doenças Genéticas Inatas/genética , Doenças Genéticas Inatas/metabolismo , Doenças Genéticas Inatas/patologia , Doenças Genéticas Inatas/veterinária , Queratinócitos/metabolismo , Queratinócitos/patologia , Masculino , Doenças Nasais/genética , Doenças Nasais/metabolismo , Doenças Nasais/patologia , Doenças Nasais/veterinária , Paraceratose/genética , Paraceratose/metabolismo , Paraceratose/patologia , Paraceratose/veterinária
14.
Rheumatology (Oxford) ; 59(6): 1196-1197, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-32118271
15.
Proc Natl Acad Sci U S A ; 117(13): 7255-7262, 2020 03 31.
Artigo em Inglês | MEDLINE | ID: mdl-32179668

RESUMO

Disease outbreaks and pathogen introductions can have significant effects on host populations, and the ability of pathogens to persist in the environment can exacerbate disease impacts by fueling sustained transmission, seasonal epidemics, and repeated spillover events. While theory suggests that the presence of an environmental reservoir increases the risk of host declines and threat of extinction, the influence of reservoir dynamics on transmission and population impacts remains poorly described. Here we show that the extent of the environmental reservoir explains broad patterns of host infection and the severity of disease impacts of a virulent pathogen. We examined reservoir and host infection dynamics and the resulting impacts of Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome, in 39 species of bats at 101 sites across the globe. Lower levels of pathogen in the environment consistently corresponded to delayed infection of hosts, fewer and less severe infections, and reduced population impacts. In contrast, an extensive and persistent environmental reservoir led to early and widespread infections and severe population declines. These results suggest that continental differences in the persistence or decay of P. destructans in the environment altered infection patterns in bats and influenced whether host populations were stable or experienced severe declines from this disease. Quantifying the impact of the environmental reservoir on disease dynamics can provide specific targets for reducing pathogen levels in the environment to prevent or control future epidemics.


Assuntos
Quirópteros/microbiologia , Reservatórios de Doenças/microbiologia , Micoses/epidemiologia , Animais , Ascomicetos/patogenicidade , Epidemias , Hibernação , Micoses/microbiologia , Nariz/microbiologia , Doenças Nasais/epidemiologia , Doenças Nasais/microbiologia , Dinâmica Populacional , Estações do Ano
16.
PLoS Pathog ; 16(3): e1008364, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32150572

RESUMO

Innate immunity responds to pathogens by producing alarm signals and activating pathways that make host cells inhospitable for pathogen replication. The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells, forming multinucleated giant cells (MNGCs) which promote bacterial replication. We show that type I interferon (IFN) restricts macrophage MNGC formation during B. thailandensis infection. Guanylate-binding proteins (GBPs) expressed downstream of type I IFN were required to restrict MNGC formation through inhibition of bacterial Arp2/3-dependent actin motility during infection. GTPase activity and the CAAX prenylation domain were required for GBP2 recruitment to B. thailandensis, which restricted bacterial actin polymerization required for MNGC formation. Consistent with the effects in in vitro macrophages, Gbp2-/-, Gbp5-/-, GbpChr3-KO mice were more susceptible to intranasal infection with B. thailandensis than wildtype mice. Our findings reveal that IFN and GBPs play a critical role in restricting cell-cell fusion and bacteria-induced pathology during infection.


Assuntos
Infecções por Burkholderia/imunologia , Burkholderia/imunologia , Proteínas de Ligação ao GTP/imunologia , Células Gigantes/imunologia , Macrófagos/imunologia , Doenças Nasais/imunologia , Prenilação de Proteína/imunologia , Animais , Infecções por Burkholderia/genética , Infecções por Burkholderia/patologia , Fusão Celular , Proteínas de Ligação ao GTP/genética , Células Gigantes/microbiologia , Células Gigantes/patologia , Interferon Tipo I/genética , Interferon Tipo I/imunologia , Macrófagos/microbiologia , Macrófagos/patologia , Camundongos , Camundongos Knockout , Doenças Nasais/genética , Doenças Nasais/microbiologia , Doenças Nasais/patologia
18.
Plast Reconstr Surg ; 145(3): 591e-603e, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32097323

RESUMO

The surgical techniques and execution of primary cleft lip and palate repair are no longer the greatest challenge to achieving successful rehabilitation for those born with facial clefting (i.e., bilateral and unilateral cleft lip and palate). Despite a surgeon's best efforts, when cleft palate repair is carried out during infancy, by the mixed dentition, a majority will demonstrate nasomaxillary deficiency. The cleft team's commitment to a family under their care is to ensure that the newborn reaches adulthood reconstructed without need for special regard to their original birth malformation. Guiding principles are provided for the accurate diagnosis and reliable reconstruction of the bilateral and unilateral cleft lip and palate adolescent/adult who presents with nasomaxillary deficiency and any residual oronasal fistula, bony defects, cleft dental gap(s), nasal obstructions, and associated facial dysmorphology. Successful orthognathic surgery provides a stable foundation on which any remaining soft-tissue cleft lip or cleft nasal deformities can be accurately assessed and then reconstructed.


Assuntos
Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Doenças Maxilares/cirurgia , Doenças Nasais/cirurgia , Procedimentos Cirúrgicos Ortognáticos/métodos , Procedimentos Cirúrgicos Reconstrutivos/métodos , Adolescente , Fenda Labial/complicações , Fissura Palatina/complicações , Feminino , Humanos , Lactente , Masculino , Doenças Maxilares/etiologia , Doenças Nasais/etiologia
19.
J Craniofac Surg ; 31(3): e303-e306, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31977685

RESUMO

The characteristics of what is considered a beautiful face differ between Eastern and Western countries.The authors of this study analyzed beauty pageant contestants using a three-dimensional (3D) photogrammetric analysis tool. All of the 3D photographs were taken between October and November 2016 in Seoul, Korea. The participants were 43 Miss Korea contestants (Group I) and 22 Miss Paraguay contestants (Group II).In absolute length, those in Group I had longer upper and middle faces. In the proportions of volume and length, Group I had larger upper and middle faces than Group II. Widths of the lower face and entire face were also wider in Group I. The lower facial index was larger in Group I. Group I had longer noses and wider intercanthal distance, not only in absolute length but also in proportion to the face. Group II showed thicker lips, longer chins, and wider noses relative to the face. Group II had wide eyes, in the absolute measurement and in proportion to the face. Group I participants appeared to have an increased height of eyes and had wider angles in their faces as well as wider nasofrontal, labiomental, and nasomental angles.The authors objectively established reference data for faces that are considered attractive in the East and the West. The data are expected to contribute to the clinical practice of plastic surgeons.


Assuntos
Beleza , Face , Pesos e Medidas Corporais , Face/anatomia & histologia , Feminino , Humanos , Imageamento Tridimensional , Masculino , Doenças Nasais , Paraguai , Fotogrametria , República da Coreia
20.
Otolaryngol Head Neck Surg ; 162(3): 382-385, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31935161

RESUMO

Our understanding of empty nose syndrome (ENS) continues to evolve. Prior studies evaluating airway augmentation to treat ENS did not use validated disease-specific questionnaires, making the true impact of these surgeries unclear. We present a case series of 10 patients with ENS (11 procedures) who underwent the inferior meatus augmentation procedure (IMAP) between September 2014 and May 2017. Subjective outcomes of IMAP included comparisons of preoperative and postoperative assessments (1 week, 1 month, 3 months, 6 months) using the Empty Nose Syndrome 6-item Questionnaire (ENS6Q), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item Scale (GAD-7), and Sino-Nasal Outcome Test-22 (SNOT-22). The decrement in ENS6Q scores observed maintained statistical significance at 6 months (P ≤ .001). Similar results were achieved with PHQ-9, GAD-7, and SNOT-22 (P ≤ .01, P ≤ .01, P ≤ .001, respectively). IMAP can dramatically improve the quality of life of ENS patients regarding both ENS-specific symptoms and psychological well-being.


Assuntos
Procedimentos Cirúrgicos Nasais/métodos , Doenças Nasais/cirurgia , Adulto , Colágeno , Feminino , Humanos , Mucosa Intestinal/transplante , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Qualidade de Vida , Inquéritos e Questionários , Síndrome
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