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2.
Am J Trop Med Hyg ; 102(4): 884-888, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32100684

RESUMO

The impact of HIV infection on the burden of gastrointestinal pathogens in Myanmar is poorly defined. Stools of 103 HIV-infected and 105 HIV-uninfected adult outpatients at a tertiary referral hospital in Yangon were examined microscopically. Stool antigen tests for Helicobacter pylori infection were positive in 63/103 (61%) HIV-infected and 61/105 (58%) HIV-uninfected patients (P = 0.65). Soil-transmitted helminth infections were much less common, occurring in 9/103 (9%) HIV-infected and 13/103 (13%) HIV-uninfected patients (P = 0.50). One HIV-uninfected patient had Giardia duodenalis, but there were no cases of Strongyloides stercoralis, Entamoeba histolytica, Capillaria philippinensis, Isospora, Cyclospora, or Schistosoma infection in the entire cohort. Despite the high prevalence of H. pylori, only 1/208 (0.5%) had ever received eradication, compared with 159/208 (76%) who had ever been dewormed. Helicobacter pylori appears to be an underappreciated pathogen in Myanmar. Its strong association with gastric cancer and peptic ulcer disease necessitates a more aggressive approach to its management.


Assuntos
Gastroenteropatias/complicações , Gastroenteropatias/epidemiologia , Infecções por HIV/complicações , Infecções por HIV/epidemiologia , Doenças Parasitárias/complicações , Doenças Parasitárias/epidemiologia , Adulto , Fezes/parasitologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mianmar/epidemiologia , Doenças Parasitárias/parasitologia
3.
Clin Exp Dermatol ; 45(5): 580-583, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31916616

RESUMO

Skin disorders are frequent in travellers, but data vary between different studies. The objectives of the current study were to describe imported dermatoses in the Bordeaux GeoSentinel prospective database between August 2015 and March 2018. During the study period, 1025 travellers were seen in the clinic, 201 of them with dermatoses. Patients with skin disorders were more likely to be aged > 60 years (OR = 1.88, 95% CI 1.22-2.89), to be tourists (OR 3.04, 95% CI 2.03-4.55) and to have travelled to South America (OR = 2.18, 95% CI 1.29-3.67), and less likely to have sought pretravel advice (OR = 0.53, 95% CI 0.31-0.91). Skin bacterial infections (19.4%) and Zika virus infections (18.4%) were the most common dermatoses. Dengue fever and bacterial skin infections were the leading causes of hospitalization. The contribution of tropical diseases to imported dermatoses remains important. Lack of pretravel advice puts tourists at risk of significant diseases such as dengue fever, Zika virus and bacterial infections.


Assuntos
Dengue/epidemiologia , Dermatopatias Bacterianas/epidemiologia , Viagem , Infecção por Zika virus/epidemiologia , Instituições de Assistência Ambulatorial , França/epidemiologia , Hospitalização/estatística & dados numéricos , Hospitais de Ensino , Humanos , Micoses/epidemiologia , Doenças Parasitárias/epidemiologia , Dermatopatias/epidemiologia
4.
Am J Trop Med Hyg ; 102(1): 164-176, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31769388

RESUMO

Accurate and cost-effective identification of areas where co-endemic infections occur would enable public health managers to identify opportunities for implementation of integrated control programs. Dried blood spots collected during cross-sectional lymphatic filariasis surveys in coastal Kenya were used for exploratory integrated detection of IgG antibodies against antigens from several parasitic infections (Wuchereria bancrofti, Schistosoma mansoni, Plasmodium spp., Ascaris lumbricoides, and Strongyloides stercoralis) as well as for detection of responses to immunizing agents used against vaccine-preventable diseases (VPDs) (measles, diphtheria, and tetanus) using a multiplex bead assay (MBA) platform. High heterogeneity was observed in antibody responses by pathogen and antigen across the sentinel sites. Antibody seroprevalence against filarial antigens were generally higher in Ndau Island (P < 0.0001), which also had the highest prevalence of filarial antigenemia compared with other communities. Antibody responses to the Plasmodium species antigens circumsporozoite protein (CSP) and merozoite surface protein-1 (MSP-1)19 were higher in Kilifi and Kwale counties, with Jaribuni community showing higher overall mean seroprevalence (P < 0.0001). Kimorigo community in Taita-Taveta County was the only area where antibody responses against S. mansoni Sm25 recombinant antigen were detected. Seroprevalence rates to Strongyloides antigen NIE ranged between 3% and 26%, and there was high heterogeneity in immune responses against an Ascaris antigen among the study communities. Differences were observed between communities in terms of seroprevalence to VPDs. Seroprotection to tetanus was generally lower in Kwale County than in other counties. This study has demonstrated that MBA holds promise for rapid integrated monitoring of trends of infections of public health importance in endemic areas.


Assuntos
Anticorpos Anti-Helmínticos/sangue , Anticorpos Antiprotozoários/sangue , Imunoglobulina G/sangue , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/imunologia , Estudos Soroepidemiológicos , Anticorpos Antibacterianos/sangue , Anticorpos Antivirais/sangue , Difteria/prevenção & controle , Vacina contra Difteria e Tétano/imunologia , Humanos , Quênia , Sarampo/prevenção & controle , Vacina contra Sarampo/imunologia , Tétano/prevenção & controle
5.
Am J Trop Med Hyg ; 102(2): 313-317, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31769396

RESUMO

Parasitic infections are a public health problem that affects all population levels in developing countries including Palestine. The current study describes the epidemiology of parasitic infections in Palestine from 2008 to 2017. Twelve prominent parasitic infections were reported: leishmaniasis (both cutaneous and visceral), malaria, hydatid disease caused by hydatid cysts, toxoplasmosis, ascariasis, oxyuriasis, strongyloidiasis, taeniasis caused by Taenia saginata, amebiasis, giardiasis, and scabies. A total of 137,106 cases were reported; among them, 92,494 (67%) in the Gaza Strip and 44,612 (33%) in the West Bank. This study provides baseline information for better understanding the status of parasitic infections in Palestine and compares their epidemiology between the West Bank and Gaza Strip. Appropriate control measures and health education directed to the public about preventive measures should be considered to raise awareness about parasitic infections to lower their incidences and burden in Palestine.


Assuntos
Doenças Parasitárias/epidemiologia , Oriente Médio/epidemiologia , Estudos Retrospectivos , Fatores de Tempo
6.
Acta Trop ; 201: 105219, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31614120

RESUMO

As the only specialized institution for research and control of parasitic diseases at the national level in China for almost 70 years, the National Institute of Parasitic Diseases (NIPD) at the Chinese Center for Disease Control and Prevention (China CDC) has been instrumental in supporting the remarkable progress from high prevalence to transmission interruption or low endemicity of several diseases, lymphatic filariasis, malaria and schistosomiasis in particular. This has taken place through technical guidance, emergency response and scientific research as well as providing technical service, education, training, health promotion and international cooperation. With China's increasing involvement in international cooperation and the increased risk for (re)emerging tropical diseases in mind, the Chinese Government designated in 2017 a new Chinese Center for Tropical Disease Research to NIPD. Responding to the expanded responsibilities, the institute is scaling up its activities in several ways: from parasitic diseases to the wider area of tropical diseases; from disease control to disease elimination; from biological research to policy evidences accumulation; and from public health to global health. Based on this new vision and China's previous accomplishments in the areas mentioned, the institute is in a position to move forward with respect to global health and equitable development according to the central principles of the United Nations' Sustainable Development Goals.


Assuntos
Centers for Disease Control and Prevention, U.S./organização & administração , Doenças Transmissíveis/epidemiologia , Saúde Global/normas , Cooperação Internacional , Doenças Parasitárias/epidemiologia , Saúde Pública/normas , Medicina Tropical/normas , Academias e Institutos , Animais , China/epidemiologia , Humanos , Objetivos Organizacionais , Estados Unidos
7.
BMC Public Health ; 19(1): 1645, 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31805904

RESUMO

BACKGROUND: Although they are declining worldwide, neurotropic parasitic diseases are still common in developing and emerging countries. The aim of this study was to estimate the pooled prevalence and pooled association measures of comorbidities between mental disorders (anxiety, depression, bipolar disorder, and schizophrenia) and neurotropic parasitic diseases (malaria, cysticercosis, toxoplasmosis, human African trypanosomiasis, Chagas disease, and human toxocariasis) in developing and emerging countries. METHODS: As the first meta-analysis on this topic, this study was performed in accordance with PRISMA guidelines. The protocol was registered in PROSPERO (N°CRD42017056521). The Medline, Embase, Lilacs, and Institute of Epidemiology and Tropical Neurology databases were used to search for articles without any restriction in language or date. We evaluated the quality of studies independently by two investigators using the Downs and Black assessment grid and pooled estimates using the random-effects method from CMA (Comprehensive Meta Analysis) Version 3.0. RESULTS: In total, 18 studies published between 1997 and 2016 met our inclusion criteria. We found that the prevalence of anxiety and depression in people suffering from Chagas disease and/or neurocysticercosis was 44.9% (95% CI, 34.4-55.9). In 16 pooled studies that included 1782 people with mental disorders and 1776 controls, toxoplasmosis and/or toxocariasis were associated with increased risk of schizophrenia and/or bipolar disorders (odds ratio = 2.3; 95% CI, 1.7-3.2). Finally, toxocariasis and/or toxoplasmosis were associated with an increased risk of the onset of schizophrenia (odds ratio = 2.4; 95% CI, 1.7-3.4). CONCLUSION: Our pooled estimates show that the associations between diseases studied are relatively high in developing and emerging countries. This meta-analysis supports the hypothesis that toxoplasmosis could be the cause of schizophrenia. These findings could prove useful to researchers who want to further explore and understand the associations studied.


Assuntos
Países em Desenvolvimento/estatística & dados numéricos , Transtornos Mentais/epidemiologia , Doenças Parasitárias/epidemiologia , Comorbidade , Humanos , Prevalência
8.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(5): 546-548, 2019 Aug 02.
Artigo em Chinês | MEDLINE | ID: mdl-31713392

RESUMO

OBJECTIVE: To understand and master the infection status of key parasitic diseases in Baise City from 2006 to 2015, so as to provide evidence for the development and adjustment of the control strategy for parasitic diseases. METHODS: The relevant information of the final evaluation of the key parasitic diseases in 12 counties (cities and districts) of Baise City from 2006 to 2015 was collected, and analyzed. RESULTS: During the period of 2006-2015, a total of 20 654 person-times were investigated for parasitic diseases in Baise City and 1 147 persons were infected, with an average infection rate of 5.55%. In 2006, the infection rate was the highest (28.67%, 362/1 254), while the lowest was in 2013 (2.08%, 44/2 113). The infection rate of Clonorchis sinensis was the highest, and the infection rate of Ascaris lumbricoides was the second. The infection rates of the males and females were 5.35% (631/11 795) and 5.82% (516/8 859) respectively, with no significant difference between them (χ2 = 2.175, P > 0.05). The highest infection rate existed in the 40-49 years group, the rural residents, the farmers and the crowd with the educational level of senior high middle school or above. CONCLUSIONS: The infection rate of parasitic diseases presents a decline trend overall in Baise City from 2006 to 2013, however it rebounded in 2014 and 2015. The next step is to strengthen the prevention and control of parasitic diseases by promoting health education, regular insect repellent, and fecundity management.


Assuntos
Enteropatias Parasitárias , Doenças Parasitárias , Fatores Etários , Animais , China/epidemiologia , Cidades , Feminino , Humanos , Enteropatias Parasitárias/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças Parasitárias/epidemiologia , Vigilância da População , Fatores de Risco , População Rural
9.
Nat Commun ; 10(1): 5032, 2019 11 06.
Artigo em Inglês | MEDLINE | ID: mdl-31695043

RESUMO

Diverse host communities commonly inhibit the spread of parasites at small scales. However, the generality of this effect remains controversial. Here, we present the analysis of 205 biodiversity-disease relationships on 67 parasite species to test whether biodiversity-disease relationships are generally nonlinear, moderated by spatial scale, and sensitive to underrepresentation in the literature. Our analysis of the published literature reveals that biodiversity-disease relationships are generally hump-shaped (i.e., nonlinear) and biodiversity generally inhibits disease at local scales, but this effect weakens as spatial scale increases. Spatial scale is, however, related to study design and parasite type, highlighting the need for additional multiscale research. Few studies are unrepresentative of communities at low diversity, but missing data at low diversity from field studies could result in underreporting of amplification effects. Experiments appear to underrepresent high-diversity communities, which could result in underreporting of dilution effects. Despite context dependence, biodiversity loss at local scales appears to increase disease, suggesting that at local scales, biodiversity loss could negatively impact human and wildlife populations.


Assuntos
Biodiversidade , Interações Hospedeiro-Parasita , Características de Residência , Ecologia , Humanos , Modelos Biológicos , Doenças Parasitárias/epidemiologia
10.
PLoS One ; 14(11): e0225508, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31770393

RESUMO

INTRODUCTION: In South Korea, Health Insurance Review and Assessment claims data contain comprehensive information on healthcare services for almost the entire population. The present study used claims data on parasitic diseases from 2011 to 2018, and associated medical expenses to investigate infection trends associated with endemic parasitic diseases in South Korea, including those not monitored by Korea Centers for Disease Control and Prevention. METHODS: Basic data regarding each parasitic disease were curated from the Healthcare Bigdata Hub (http://opendata.hira.or.kr). Ten endemic parasitic diseases, three pandemic protozoan diseases, and three ectoparasitic diseases were evaluated between 2011 and 2018. Data on each parasitic disease included the number of patients of each sex, age range within 5 years, province, and total medical expenses. Heatmap and principal component analysis were performed to visualize the incidence pattern of parasitic diseases by provinces. RESULTS: Clonorchiasis and pinworm infections decreased remarkably from 6,097 and 4,018 infections in 2011 to 3,008 and 1,988 infections in 2018, respectively. Other endemic parasitic diseases mostly declined or remained steady over the 8-year period, except for anisakiasis, which doubled from 409 in 2011 to 818 in 2018. Provinces close to North Korea had a higher frequency of claims for Plasmodium vivax infection. The highest rate of clonorchiasis was in Gyeongsangnam-do, while that of anisakiasis was in southern Korea. Jeju province had the highest number of claims for cysticercosis, anisakiasis, pinworm infection, and soil-transmitted helminth infections. The total medical expense for anisakiasis was 65 million Korean won (57,000 US$) in 2011, rising to 237 million Korean won (206,000 US$) in 2018. The medical expense for trichomoniasis was 6,063 million won and for scabies was 1,669 million won in 2018. Since the claims data include only data reported by healthcare providers, some discrepancies might have occurred. CONCLUSION: Our findings provide the basis for a health policy to reduce further infections and medical expense.


Assuntos
Gastos em Saúde , Doenças Parasitárias/epidemiologia , Clonorquíase/economia , Clonorquíase/epidemiologia , Bases de Dados Factuais , Enterobíase/economia , Enterobíase/epidemiologia , Gastos em Saúde/tendências , Humanos , Programas Nacionais de Saúde , Doenças Parasitárias/economia , Análise de Componente Principal , República da Coreia/epidemiologia
11.
PLoS Pathog ; 15(11): e1008008, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31751405

RESUMO

The shape and number of mitochondria respond to the metabolic needs during the cell cycle of the eukaryotic cell. In the best-studied model systems of animals and fungi, the cells contain many mitochondria, each carrying its own nucleoid. The organelles, however, mostly exist as a dynamic network, which undergoes constant cycles of division and fusion. These mitochondrial dynamics are driven by intricate protein machineries centered around dynamin-related proteins (DRPs). Here, we review recent advances on the dynamics of mitochondria and mitochondrion-related organelles (MROs) of parasitic protists. In contrast to animals and fungi, many parasitic protists from groups of Apicomplexa or Kinetoplastida carry only a single mitochondrion with a single nucleoid. In these groups, mitochondrial division is strictly coupled to the cell cycle, and the morphology of the organelle responds to the cell differentiation during the parasite life cycle. On the other hand, anaerobic parasitic protists such as Giardia, Entamoeba, and Trichomonas contain multiple MROs that have lost their organellar genomes. We discuss the function of DRPs, the occurrence of mitochondrial fusion, and mitophagy in the parasitic protists from the perspective of eukaryote evolution.


Assuntos
Dinâmica Mitocondrial , Parasitos/patogenicidade , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/fisiopatologia , Animais , Doenças Parasitárias/parasitologia
12.
Molecules ; 24(21)2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31661934

RESUMO

Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012-2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.


Assuntos
Antiprotozoários/uso terapêutico , Parasitos/efeitos dos fármacos , Doenças Parasitárias/tratamento farmacológico , Animais , Resistência a Medicamentos/efeitos dos fármacos , Parasitos/patogenicidade , Doenças Parasitárias/classificação , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/parasitologia
13.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(4): 356-357, 2019 Sep 19.
Artigo em Chinês | MEDLINE | ID: mdl-31612667

RESUMO

Spatial epidemiology is a new branch of epidemiology, and is a subject that mainly analyzes the geographical distribution and changes of population health or diseases and its related impact factors. Recently, spatial epidemiology has been extensively applied in the prevention and control of parasitic diseases in China, and delightful results have been achieved. However, the research and application of theories and methods of spatial epidemiology are still needed to protect the people's health in China.


Assuntos
Métodos Epidemiológicos , Doenças Parasitárias , China/epidemiologia , Humanos , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/prevenção & controle , Pesquisa/tendências
14.
PLoS Negl Trop Dis ; 13(10): e0007776, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31618208

RESUMO

We investigated the impact of helminths and malaria infection on Kaposi's sarcoma associated herpesvirus (KSHV) seropositivity, using samples and data collected from a cluster-randomised trial of intensive versus standard anthelminthic treatment. The trial was carried out in 2012 to 2016 among fishing communities on Lake Victoria islands in Uganda. Plasma samples from 2881 participants from two household surveys, the baseline (1310 participants) and the final (1571 participants) surveys were tested for KSHV IgG antibody responses to K8.1 and ORF73 recombinant proteins using ELISA. The baseline survey was carried out before the trial intervention while the final survey was carried out after three years of the trial intervention. Additionally, a subset sample of 372 participants from the final survey was tested for IgE, IgG and IgG4 antibody concentrations to S. mansoni adults worm antigen (SWA) and S. mansoni egg antigen (SEA) using ELISA. Infection by helminths (S. mansoni, N. americanus, T. trichiura and S. stercoralis) was diagnosed using real-time PCR, urine circulating cathodic antigen (CCA) and stool microscopy (Kato-Katz method) while malaria infection was diagnosed using microscopy. We analysed the relationship between helminth and malaria infections and KSHV seropositivity using regression modelling, allowing for survey design. At baseline, 56% of the participants were male while 48% of the participants were male in the final survey. The most prevalent helminth infection was S. mansoni (at baseline 52% and 34% in the final survey by microscopy, 86% by CCA and 50% by PCR in the final survey). KSHV seropositivity was 66% (baseline) and 56% (final survey) among those 1-12 years and >80% in those 13+ years in both surveys; malaria parasitaemia prevalence was 7% (baseline) and 4% (final survey). At baseline, individuals infected with S. mansoni (detected by microscopy) were more likely to be KSHV seropositive (aOR = 1.86 (1.16, 2.99) p = 0.012) and had higher anti-K8.1 antibody levels (acoefficient = 0.03 (0.01, 0.06) p = 0.02). In the final survey, S. mansoni (by microscopy, adjusted Odds Ratio (aOR = 1.43 (1.04-1.95), p = 0.028) and malaria parasitaemia (aOR = 3.49 (1.08-11.28), p = 0.038) were positively associated with KSHV seropositivity. Additionally, KSHV seropositive participants had higher S. mansoni-specific IgE and IgG antibody concentrations in plasma. Furthermore, HIV infected individuals on cART were less likely to be KSHV seropositive compared to HIV negative individuals (aOR = 0.46 (0.30, 0.71) p = 0.002). Schistosoma species skew the immune response towards Th2 and regulatory responses, which could impact on KSHV reactivation if co-infected with both organisms.


Assuntos
Antígenos de Helmintos/imunologia , Herpesvirus Humano 8/imunologia , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/imunologia , Adolescente , Adulto , Idoso , Albendazol/uso terapêutico , Animais , Anticorpos Anti-Helmínticos/sangue , Criança , Pré-Escolar , Estudos Transversais , Infecções por HIV/imunologia , Helmintíase/tratamento farmacológico , Helmintíase/epidemiologia , Helmintíase/imunologia , Helmintíase/parasitologia , Humanos , Imunoglobulina E/sangue , Imunoglobulina G/sangue , Lactente , Ilhas , Lagos , Malária/imunologia , Pessoa de Meia-Idade , Razão de Chances , Doenças Parasitárias/tratamento farmacológico , Doenças Parasitárias/fisiopatologia , Praziquantel/uso terapêutico , Prevalência , Schistosoma mansoni/imunologia , Esquistossomose mansoni/epidemiologia , Uganda/epidemiologia , Adulto Jovem
15.
Acta Trop ; 200: 105181, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31542370

RESUMO

China was once a country plagued by parasitic diseases. At the beginning of the founding of the People's Republic of China, nearly 80% of the population suffered from parasitic diseases because of poverty and poor sanitary conditions. After nearly 70 years of development, China has made remarkable achievements in the prevention and control of parasitic diseases, and the prevalence of parasitic diseases has been greatly reduced. In addition to organizational leadership from the government and various preventive measures, drug treatment and drug research & development are important and irreplaceable links in prevention and control work. Since the 1950s, China has begun to introduce, produce and imitate antiparasitic drugs from abroad, such as santonin, benzimidazole, and praziquantel. Chinese scientists have also contributed to the optimization of production techniques, improvements in drug formulation, the application in the clinic and the mechanisms of actions of generic drugs. At the same time, China has independently developed tribendimidine (TrBD, a broad spectrum anthelminthic), and its anthelminthic spectrum has been comprehensively studied. It is active against almost 20 parasites, is especially superior to benzimidazoles against Necator americanus, and surpasses the effectiveness of praziquantel against Clonorchis sinensis. In the treatment of tapeworm disease, the traditional Chinese medicines pumpkin seeds and betel nuts have good curative effects for taeniasis. Chinese scientists have explored the action modes and clinical administration methods of pumpkin seeds and betel nuts, which is still the main clinical regimen for the disease. This paper reviews the history and progress of the study of anthelmintics in intestinal helminth infections since the founding of the People's Republic of China and aiming to support clinicians and drug researchers in China and other countries.


Assuntos
Anti-Helmínticos/história , Anti-Helmínticos/uso terapêutico , Infecções por Cestoides/tratamento farmacológico , Helmintíase/tratamento farmacológico , Enteropatias Parasitárias/tratamento farmacológico , Doenças Parasitárias/tratamento farmacológico , Doenças Parasitárias/história , Animais , Infecções por Cestoides/epidemiologia , Infecções por Cestoides/história , China/epidemiologia , Clonorchis sinensis/efeitos dos fármacos , Helmintíase/história , História do Século XX , História do Século XXI , Humanos , Enteropatias Parasitárias/história , Doenças Parasitárias/epidemiologia , Fenilenodiaminas/uso terapêutico , Praziquantel/história , Praziquantel/uso terapêutico , Teníase/tratamento farmacológico , Teníase/história
16.
Korean J Parasitol ; 57(4): 329-339, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31533400

RESUMO

Indonesia and South Korea have become inseparable in various respects since the 2 countries established diplomatic relation in 1973. Indonesia is a tropical region that stretches across the equator, comprised of 5 main islands (Java, Kalimantan, Sumatra, Sulawesi, and Papua) and 4 archipelagoes (Riau, Bangka Belitung, Nusa Tenggara, and Maluku). As most population of Eastern Indonesia (Sulawesi, Papua and Nusa Tenggara & Maluku) live in poor areas, it is expected that there will be many parasites. Nevertheless, little is known about the status of parasites in Indonesia. This study examines the prevalences of malaria and lymphatic filaria, which are prevalent in Indonesia, as well as those of soil-transmitted-helminths (STH). As a result, the Plasmodium falciparum and P. vivax case loads are almost equal. The current prevalence of P. vivax is uniformly low (<5%) in all age groups and annual parasite incidence (API) showed decreasing tendency as 0.84 per 1,000 population in 2016. However, more than 65 million people still live in malaria epidemic regions. Lymphatic filariasis remains an important public health problem and 236 cities were classified as endemic areas in 514 cities/districts in 2017. It is difficult to ascertain the current prevalence rate of STH in Indonesia, although West Sumba and Southwest Sumba in East Nusa Tenggara reported prevalence rate of more than 20%. The study also considers the (sero) prevalences of other parasites identified in Indonesia. This report should be useful not only to parasitologists but also to travelers and people with business in Indonesia.


Assuntos
Doenças Parasitárias/epidemiologia , Filariose Linfática/epidemiologia , Helmintíase/epidemiologia , Helmintíase/transmissão , Indonésia/epidemiologia , Malária/epidemiologia , Doenças Parasitárias/transmissão , Prevalência , Esquistossomose Japônica/epidemiologia , Solo/parasitologia , Teníase/epidemiologia
17.
J Biosci ; 44(4)2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31502575

RESUMO

The parasitic nematode Haemonchus contortus is one of the world's most important parasites of small ruminants that causes significant economic losses to the livestock sector. The population structure and selection in its various strains are poorly understood. No study so far compared its different populations using genome-wide data. Here, we focused on different geographic populations of H. contours from China (Tibet, TB; Hubei, HB; Inner Mongolia, IM; Sichuan, SC), UK and Australia (AS), using genome-wide population-genomic approaches, to explore genetic diversity, population structure and selection. We first performed next-generation high-throughput 2b RAD pool sequencing using Illumina technology, and identified single-nucleotide polymorphisms (SNPs) in all the strains. We identified 75,187 SNPs for TB, 82,271 for HB, 82,420 for IM, 79,803 for SC, 83,504 for AS and 78,747 for UK strain. The SNPs revealed low-nucleotide diversity (pi= 0.0092-0.0133) within each strain, and a significant differentiation level (average Fst = 0.34264) among them. Chinese populations TB and SC, along with the UK strain, were more divergent populations. Chinese populations IM and HB showed affinities to the Australian strain. We then analysed signature of selection and detected 44 (UK) and 03 (AS) private selective sweeps containing 49 and 05 genes, respectively. Finally, we performed the functional annotation of selective sweeps and proposed biological significance to signature of selection. Our data suggest that 2b-RAD pool sequencing can be used to assess the signature of selection in H. contortus.


Assuntos
Resistência a Medicamentos/genética , Haemonchus/genética , Doenças Parasitárias/genética , Animais , Austrália/epidemiologia , China/epidemiologia , Variação Genética , Genótipo , Haemonchus/patogenicidade , Sequenciamento de Nucleotídeos em Larga Escala , Mongólia/epidemiologia , Doenças Parasitárias/epidemiologia , Doenças Parasitárias/parasitologia , Polimorfismo de Nucleotídeo Único/genética , Tibet/epidemiologia , Reino Unido/epidemiologia
18.
Parasitol Res ; 118(9): 2635-2642, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31363922

RESUMO

The geographical distribution of tuberculosis (TB) overlaps with various parasitic infections. Uncovering the characteristics of coinfecting parasites that potentially affect the host susceptibility to TB is pertinent as it may provide input to current TB therapeutic and prophylactic measures. The present study was aimed at examining the types of parasitic infections in TB patients and healthy TB contacts (HC) in Orang Asli, Malaysian aborigines, who dwelled in the co-endemic areas. Stool and serum samples were collected from Orang Asli who fulfilled the selection criteria and provided written informed consents. Selected parasitic infections in the two study groups were determined by stool examination and commercial serum antibody immunoassays. The prevalence of parasitic infections in TB and HC participants were 100% (n = 82) and 94.6% (n = 55) respectively. The parasitic infections comprised toxocariasis, trichuriasis, amoebiasis, toxoplasmosis, hookworm infection, ascariasis, strongyloidiasis, and brugian filariasis, in decreasing order of prevalence. Overall, helminth or protozoa infection did not show any significant association with the study groups. However, when the species of the parasite was considered, individuals exposed to trichuriasis and toxoplasmosis showed significant odds reduction (odds ratio (OR) 0.338; 95% confidence interval (CI) 0.166, 0.688) and odds increment (OR 2.193; 95% CI 1.051, 4.576) to have active pulmonary TB, respectively. In conclusion, trichuriasis and toxoplasmosis may have distinct negative and positive associations respectively with the increase of host susceptibility to TB.


Assuntos
Parasitos/isolamento & purificação , Doenças Parasitárias/parasitologia , Tuberculose Pulmonar/parasitologia , Adulto , Animais , Pré-Escolar , Coinfecção/epidemiologia , Coinfecção/parasitologia , Estudos Transversais , Fezes/parasitologia , Feminino , Humanos , Malásia/epidemiologia , Masculino , Pessoa de Meia-Idade , Razão de Chances , Parasitos/classificação , Parasitos/genética , Doenças Parasitárias/epidemiologia , Prevalência , Fatores de Risco , Tuberculose Pulmonar/epidemiologia , Adulto Jovem
19.
Artigo em Russo | MEDLINE | ID: mdl-31251865

RESUMO

In conditions of increased population migration, studying the situation on incidence of infectious and parasitogenic diseases is an actual problem. Particularly relevant is the analysis of newly detected incidence in the dynamics, which will allow to assess the well-being of the epidemiological situation in the region. Purpose of the study is to analyze the situation with incidence of some infectious and parasitogenic diseases and their share in the structure of other classes of diseases. The data from the Federal statistical monitoring in 2010-2017 were used related to the Russian Federation and the North Caucasus region. It is demonstrated that the incidence of diseases in the North Caucasus Federal District and the Stavropol region increased while it decreased at the National level. At that, there was a decreasing of incidence of some infectious and parasitogenic diseases both in the Russian Federation and in the North Caucasus Federal District with instability of indices in the Stavropol Krai. In the structure of primarily diagnosed diseases, infectious and parasitogenic diseases both in the the Russian Federation and in the North Caucasus Federal Okrug occupy the in the ranking table tenth point and sixth point in the Stavropol Krai. The results of the study demonstrated multi-directional trends in the dynamics of morbidity in the Russian Federation and the North Caucasus Federal Okrug. The decrease in the percentage of infectious and parasitogenic diseases testifies the improvement of epidemiological situation in overall.


Assuntos
Doenças Parasitárias , Humanos , Morbidade , Doenças Parasitárias/complicações , Doenças Parasitárias/diagnóstico , Doenças Parasitárias/epidemiologia , Federação Russa/epidemiologia
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