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1.
Medicina (Kaunas) ; 57(5)2021 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-34068221

RESUMO

The objective of this article was to conduct a systematic review of the literature to contrast the existing evidence regarding the relationship between periodontal disease (PD) and diabetes mellitus (DM) with the possibly increased risk of SARS-CoV-2 infection, as well as to establish a hypothesis that explains the ways in which this interaction could take place. A literature search up from 1 January 2020 to 21 March 2021 was conducted in three electronic databases, namely, PubMed, Web of Science, and Scopus, in order to identify studies on periodontal disease alone or in conjunction with diabetes mellitus, reporting any relation with SARS-CoV-2 infection as a primary outcome. Only articles published in the English language were included. Due to the lack of studies, we decided to collect all the theoretical and clinical evidence suggesting a possible biological pathway evidencing the relationship among PD, DM, and SARS-CoV-2 infection. From a total of 29 articles, 12 were included for final review studies (five reviews, two hypotheses, one Special Issue, one perspective, one commentary, one case-control study, and one case report). In addition, this systematic review article hypothesizes the correlation between PD and type 2 diabetes mellitus (T2DM) by expression of angiotensin-converting enzyme 2 (ACE2) in periodontal tissue and the risk of SARS-CoV-2 infection. T2DM is a metabolic disorder characterized by high blood glucose levels resulting from altered insulin secretion or action. Likewise, periodontitis and T2DM are inflammatory disorders with a bidirectional association, and both diseases have a similar immunomodulatory cascade and cytokine profile. ACE2 is a crucial component of the renin-angiotensin system (RAS) and the key factor of entry in the cells by the new SARS-CoV-2. ACE2 is widely distributed in the lung and kidneys, and interestingly has a great distribution in the oral cavity, principally in the tongue and periodontal tissue. ACE2 in periodontal tissue plays a crucial role between health and disease. Moreover, the ACE2/Ang-(1-7)/MasR axis is downregulated in the dysbiotic and inflammatory periodontal environment. Nevertheless, the balance of ACE2 activity is modified in the context of concurrent diabetes, increasing the expression of ACE2 by the uncontrolled glycemia chronic in T2DM. Therefore, the uncontrolled hyperglycemia possibly increases the risk of developing periodontitis and triggering overexpression of ACE2 in periodontal tissue of T2DM patients, with these events potentially being essential to SARS-CoV-2 infection and the development of mild-to-severe form of COVID-19. In this sense, we would like to point out that the need for randomized controlled trials is imperative to support this association.


Assuntos
COVID-19 , Diabetes Mellitus Tipo 2 , Doenças Periodontais , Estudos de Casos e Controles , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Humanos , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia , Sistema Renina-Angiotensina , SARS-CoV-2
2.
Wiad Lek ; 74(5): 1065-1068, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34090265

RESUMO

OBJECTIVE: The aim: To study the clinical efficciency of the proposed scheme of gingivitis treatment in women with physiological course of pregnancy. PATIENTS AND METHODS: Materials and methods: Clinical approbation of the proposed complex of therapeutic and prophylactic measures was carried out in 32 pregnant women with gingivitis, aged 18 to 35 years. The efficiency of the treatment was assessed by the dynamics of the clinical picture, the index assessment of an oral hygiene and the periodontium condition in each trimester of pregnancy. RESULTS: Results: According to the data of performed observations, the high efficiency of the proposed treatment scheme is shown: 84.4% in the main group versus 46.9% in the control group. It has been clinically proven that the proposed scheme of inflammatory periodontal diseases treatment in terms of therapeutic efficiency exceeds the generally accepted basic treatment. CONCLUSION: Conclusions:The use of the proposed complex of therapeutic and prophylactic measures in the main group of patients contributed to the elimination of the inflammatory process in the periodontal tissues, suspended the progression of existing diseases, made it possible to prevent the emergence of new nosological forms, improved the condition of the oral hygiene, which makes it possible to recommend it for treatment of periodontal diseases in pregnant women.


Assuntos
Gengivite , Doenças Periodontais , Complicações na Gravidez , Feminino , Gengivite/prevenção & controle , Humanos , Doenças Periodontais/prevenção & controle , Periodonto , Gravidez , Complicações na Gravidez/prevenção & controle , Gestantes
3.
Wiad Lek ; 74(5): 1262-1267, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34090302

RESUMO

OBJECTIVE: The aim: Of the study is to analyze the literary data regarding evaluation of the pathogenetic mechanisms of the interaction of systemic diseases and periodontal tissue damage, conducted on the basis of scientific researches of Ukrainian and foreign scientists. PATIENTS AND METHODS: Materials and methods: Bibliosematic and analytical methods were used in the research. The materials of the exploration are international experience in the study of pathogenetic mechanisms of the interplay of pathology in the cardiovascular, respiratory systems, diseases of the gastrointestinal tract and chronic generalized damage of periodontal tissues. CONCLUSION: Conclusions: It is important to search for new modern methods of diagnosis and individual approach to primary and secondary prevention of changes in periodontal tissues on the background of general pathology. The only way to solve this problem is a detailed study of somatic and dental history, changes in all body systems, on the basis of which it is possible to create a reasonable set of individual preventive measures and improve the treatment of periodontal disorders.


Assuntos
Doenças Periodontais , Comorbidade , Humanos , Doenças Periodontais/epidemiologia , Periodonto
4.
J Pak Med Assoc ; 71(5): 1345-1349, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34091612

RESUMO

Objective: To determine the association of depression with dental caries and periodontal disease. METHODS: The cross-sectional descriptive study was conducted at the Nishtar Institute of Dentistry, Multan, Pakistan, from May 7, 2018 to January 7, 2019, and comprised samples from subjects with dental caries and periodontal disease. Hospital Anxiety and Depression Scale was applied to screen the participants for the presence or absence of depression. Data was analysed using SPSS 21. RESULTS: Of the 296 participants, 125(42.2%) were males and 171(57.7%) were females. The overall mean age was 38.74±12.87 years. Depression was found in 195(65.8%) patients. Significant association of depression in patients of dental caries and periodontal disease was found with female gender, age <50 years, illiteracy, marital status, pre-existing hypertension, coronary artery disease, illicit substance addiction and psychotropic medication use (p<0.05). Conclusion: There was high frequency of depression among patients of dental caries and periodontal disease.


Assuntos
Cárie Dentária , Doenças Periodontais , Adulto , Estudos Transversais , Cárie Dentária/epidemiologia , Depressão/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paquistão/epidemiologia , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia , Centros de Atenção Terciária
5.
J Contemp Dent Pract ; 22(1): 73-79, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34002713

RESUMO

AIM: This study aimed to compare the level of interleukin (IL)-10, IL-17, IL-27, IL-35, and IL-37 in the gingival crevicular fluid (GCF) and human plasma of subjects with periodontal disease. MATERIALS AND METHODS: In this cross-sectional study conducted over a 3-month period at a primary dental clinic in Malaysia, 45 participants were recruited via consecutive sampling and assigned into three groups, namely healthy periodontium group (n = 15), gingivitis group (n = 15), and periodontitis group (n = 15). Gingival crevicular fluid and plasma samples were collected from each participant. Enzyme-linked immunosorbent assay test was conducted to measure the concentration of IL-10, IL-17, IL-27, IL-35, and IL-37. Kruskal-Wallis H test was used to compare the interleukin levels between patient groups. RESULTS: In GCF samples, IL-17 level was the highest in the periodontitis group (p <0.05), while IL-27 was the lowest (p <0.05). Meanwhile, plasma levels of IL-27 and IL-37 were significantly lower (p <0.05) in the periodontitis group, but plasma IL-35 levels were observed to rise with increasing disease severity. CONCLUSION: There are reduced local and systemic levels of IL-27 in periodontitis patients. CLINICAL SIGNIFICANCE: Periodontal diseases exert both local and systemic effects, resulting in the destruction of the tooth-supporting structures and contributing to the systemic inflammatory burden. Some of the cytokines that were investigated in the current study, IL-17, IL-27, IL-35, and IL-37, can be potential biomarkers that warrant further longitudinal clinical studies to determine their usefulness as prognostic/diagnostic markers.


Assuntos
Gengivite , Interleucina-27 , Doenças Periodontais , Estudos Transversais , Líquido do Sulco Gengival/química , Humanos , Interleucina-10 , Interleucina-17 , Interleucinas/análise , Malásia
6.
Oral Health Prev Dent ; 19(1): 295-299, 2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-34057339

RESUMO

PURPOSE: The objective of this cross-sectional study was to evaluate the relationship between ABO blood groups and periodontal diseases. MATERIALS AND METHODS: Four hundred sixteen subjects (223 females, 193 males) were recruited according to the eligibility criteria. Periodontal examination was performed, including full-mouth plaque index (PI), bleeding on probing (BOP), clinical attachment level (CAL), and interproximal bone loss (IBL). ABO blood group patterns were determined based on self-reports, confirmed by medical records. The chi-squared test was done to evaluate the data (p < 0.05). RESULTS: Out of the 416 subjects, 52.2% were blood group O, whereas 27.8% were blood group A. 46.8% of patients with blood group O had gingivitis and 49.6% had periodontitis. 31.2% of patients with blood group A had gingivitis,while 29.5% had periodontitis. The blood group with the lowest percentage among patients with gingivitis was AB, with a rate of 6.2%; in this blood group, 8.1% had periodontitis. CONCLUSIONS: There is no association between periodontal diseases and ABO blood group types.


Assuntos
Gengivite , Doenças Periodontais , Periodontite , Sistema ABO de Grupos Sanguíneos , Estudos Transversais , Feminino , Gengivite/epidemiologia , Humanos , Masculino , Doenças Periodontais/epidemiologia
7.
BMC Oral Health ; 21(1): 229, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-33941169

RESUMO

BACKGROUND: The relationship between dental caries and periodontal disease is still controversial. The objective of this study was to explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. METHODS: The study population consisted of 4407 middle-aged and 4117 elderly subjects. Caries were divided into the following three types: type A, crown caries; type B, lesions involving both the crown and root, representing mixed-type caries; and type C, root caries. These three types together represent the overall caries situation, which we call type ABC. Caries were quantitated by decayed and filled teeth (DFT index). Periodontitis was evaluated by clinical attachment loss. RESULTS: Middle-aged people with periodontitis had a significant association with DFT type B (OR: 1.21, 95% CI 1.17-1.25) and type C (OR: 1.40, 95% CI 1.24-1.56). Elderly people with periodontitis had a significant association with DFT type C (OR: 1.28, 95% CI 1.21-1.35). CONCLUSIONS: In China, caries types B/C were positively correlated with periodontitis in the middle-aged group, and only caries type C was positively correlated with periodontitis in the elderly group.


Assuntos
Cárie Dentária , Doenças Periodontais , Idoso , China/epidemiologia , Índice CPO , Cárie Dentária/epidemiologia , Suscetibilidade à Cárie Dentária , Inquéritos de Saúde Bucal , Humanos , Pessoa de Meia-Idade , Saúde Bucal , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia
8.
BMC Oral Health ; 21(1): 245, 2021 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-33962608

RESUMO

BACKGROUND: Periodontal disease represents a major health concern. The administration of beneficial microbes has been increasing in popularity over efforts to manipulate the microbes using antimicrobial agents. This study determined the ability of Streptococcus salivarius to inhibit IL-6 and IL-8 production by gingival fibroblasts when activated by periodontal pathogens and their effect on the salivary microbiome. METHODS: Primary human gingival fibroblasts were challenged with Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum and a combination of all three. IL-6 and IL-8 cytokine release were measured. Using this same model, S. salivarius K12, M18 and different supernatant and whole-cell lysate fractions of S. salivarius K12 were administered to pathogen-induced fibroblasts. A patient study of healthy participants was also conducted to determine the effect S. salivarius K12 had on the native microbiome using 16S next generation sequence analysis. RESULTS: All pathogens tested induced a significant IL-6 and IL-8 response. S. salivarius K12 or M18, did not exhibit an increase in inflammatory cytokines. When either of the probiotic strains were co-administered with a pathogen, there were significant reductions in both IL-6 and IL-8 release. This effect was also observed when gingival fibroblasts were pre-treated with either S. salivarius K12 or M18 and then stimulated with the oral pathogens. Chewing gum containing S. salivarius K12 did not alter the salivary microbiome and did not increase inflammatory markers in the oral cavity. CONCLUSION: S. salivarius K12 and M18 prevented immune activation induced by periodontal disease pathogens. S. salivarius K12 did not alter the salivary microbiome or induce immune activation when administered as a chewing gum. These results warrant further study to determine if it may be an effective treatment in a model of periodontal disease.


Assuntos
Doenças Periodontais , Streptococcus salivarius , Aggregatibacter actinomycetemcomitans , Fusobacterium nucleatum , Humanos , Porphyromonas gingivalis
9.
Stomatologiia (Mosk) ; 100(2): 76-85, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33874666

RESUMO

The article presents the «Classification of periodontal diseases and the state of perimplant tissues¼, adopted at the international Congress Euro-Perio-9 in 2018. The advantages and disadvantages of this systematics in comparison with the previous ones and with the classification currently adopted in the Russian Federation are noted.


Assuntos
Implantes Dentários , Peri-Implantite , Doenças Periodontais , Periodontite , Humanos , Doenças Periodontais/epidemiologia , Periodontite/epidemiologia , Federação Russa/epidemiologia
10.
Pol Merkur Lekarski ; 49(290): 125-128, 2021 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-33895758

RESUMO

The results of epidemiological studies as well as statistical data show that in recent years the dental morbidity rate in the world has remained stable at a high level. Inflammatory diseases of periodontal tissues, in particular generalized forms of periodontitis, reach 80% in the world. The tendency of increasing the prevalence rate of these diseases in Ukraine, 60-99%, is being observed nowadays. AIM: The aim of this study was to examine the antimicrobial activity of three gel-based medicinal products, being widely used in periodontology: Abigel, an herbal remedy, containing fir oil and oak bark extract; Fitoron, which contains oak bark extract, and President gel with chlorhexidine. MATERIALS AND METHODS: Gram-positive and gram-negative bacteria, belonging to different taxonomic groups: Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Bacillus subtilis ATCC 6633 and Proteus vulgaris ATCC 4636, Candida albicans ATCC 885-653, were as a substrate for further examinations. Preparing the suspensions of microorganisms with a defined optical density of microbial cells was executed using the turbidity standard (0.5 McFarland standard). The Densi-La-Meter device (made by "PLIVA-Lachema", Czech Republic; wavelength = 540 nm) was used. The suspension was prepared in accordance with the device guidance and the information sheet on innovations in the health care system No. 163-2006 "Standardization of preparation of microbial suspensions". RESULTS: The highest activity against Staphylococcus aureus is being observed in President gel with chlorhexidine (24 mm and 25 mm), followed by Abigel gel (20, 21, 22 mm) and Fitoron has the minimum activity (17 and 18 mm). The growth zone of Bacillus subtilis is maximally inhibited by President gel with chlorhexidine (25 and 26 mm), Fitoron's inhibition zone is of 23 and 24 mm, and in the last place is Abigel gel - 20 and 21 mm. President gel with chlorhexidine has a pronounced antifungal effect with the inhibition zone of 20, 21 and 22 mm, Fitoron's inhibition zone is of 19 and 20 mm, and one of Abigel gel - of 16 and 17 mm. Concerning Enterococcus faecalis, the highest activity was established in President gel with chlorhexidine (the inhibition zone of 22 and 23 mm), Abigel gel had inhibition zone of 20 and 21 mm, whereas one of Fitoron was of 18 and 19 mm. Haemophilus influenzae was maximally influenced by President gel with chlorhexidine with the inhibition zone of 19 and 20 mm, Abigel gel caused the growth inhibition by 17 and 18 mm, and the lowest growth inhibition was of Fitoron - 16 mm. President gel with chlorhexidine (19, 20, 21 mm) and Abigel gel (19 mm) had almost the same influence on the growth of Streptococcus pyogenes, whereas these figures of Fitoron were 16 and 17 mm. Abigel gel had a pronounced activity against Streptococcus mutans with the inhibition zone of 20 mm, one of President gel with chlorhexidine was of 19 and 20 mm, and of Fitoron - 17 and 18 mm. The growth of Neisseria sp was maximally inhibited by President gel with chlorhexidine (18, 19, 20 mm), in the second place was Abigel gel (18, 19 mm) and the lowest results were of Fitoron (16, 17 mm). CONCLUSIONS: President gel with chlorhexidine, Fitoron and Abigel gel have pronounced antimicrobial properties as to the testing cultures of microorganisms under study. Abigel is an effective method of choice in the conservative treatment of inflammatory periodontal diseases.


Assuntos
Antibacterianos , Doenças Periodontais , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Tratamento Conservador , Bactérias Gram-Negativas , Bactérias Gram-Positivas , Humanos , Testes de Sensibilidade Microbiana , Doenças Periodontais/tratamento farmacológico
11.
Molecules ; 26(6)2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33804244

RESUMO

Periodontal diseases are multifactorial disorders, mainly due to severe infections and inflammation which affect the tissues (i.e., gum and dental bone) that support and surround the teeth. These pathologies are characterized by bleeding gums, pain, bad breath and, in more severe forms, can lead to the detachment of gum from teeth, causing their loss. To date it is estimated that severe periodontal diseases affect around 10% of the population worldwide thus making necessary the development of effective treatments able to both reduce the infections and inflammation in injured sites and improve the regeneration of damaged tissues. In this scenario, the use of 3D scaffolds can play a pivotal role by providing an effective platform for drugs, nanosystems, growth factors, stem cells, etc., improving the effectiveness of therapies and reducing their systemic side effects. The aim of this review is to describe the recent progress in periodontal regeneration, highlighting the influence of materials' properties used to realize three-dimensional (3D)-scaffolds, their bio-physical characteristics and their ability to provide a biocompatible platform able to embed nanosystems.


Assuntos
Regeneração Óssea/efeitos dos fármacos , Doenças Periodontais/terapia , Tecidos Suporte/química , Animais , Materiais Biocompatíveis/química , Humanos , Engenharia Tecidual/métodos
12.
J Int Acad Periodontol ; 23(2): 150-166, 2021 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-33929931

RESUMO

Aims: To assess the periodontal status in cannabis smokers in comparison with non-cannabis smokers. Materials and methods: Electronic databases were searched as well as hand searches performed. Eligible studies followed the Population Exposure Comparison Outcome Study (PECOS) structure: P: dentate humans, E: cannabis smoking, C: non-cannabis smoking, O: Primary outcomes: periodontitis case definition, clinical attachment loss, probing depth; Secondary outcomes: bleeding on probing/ gingival inflammation, plaque index and calculus; S: observational studies. Qualitative analyses of the studies were done. The quality of cohort studies was assessed with the Newcastle-Ottawa scale and cross-sectional studies were assessed using a modified Newcastle-Ottawa scale. Results: 2661 records were screened, of which 14 articles were included. Data from a cohort study showed that highly exposed participants were at higher risk of clinical attachment loss progression. Six cross-sectional studies reported worse gingival or periodontal conditions in cannabis smokers. Nevertheless, one did not find such association, neither did three case series. Three studies were of high, two of moderate and six were of low quality. Conclusions: Based on the available data, frequent cannabis smoking could be detrimental for periodontal tissues and this could be dose-dependent. Studies including long-term cannabis smokers, and stratified for periodontal disease etiologic factors and risk factors/indicators are needed.


Assuntos
Cannabis , Doenças Periodontais , Periodontite , Estudos de Coortes , Estudos Transversais , Humanos , Perda da Inserção Periodontal , Doenças Periodontais/epidemiologia , Fumantes
13.
Medicina (Kaunas) ; 57(3)2021 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-33802358

RESUMO

Periodontitis is among the most common health conditions and represents a major public health issue related to increasing prevalence and seriously negative socioeconomic impacts. Periodontitis-associated low-grade systemic inflammation and its pathological interplay with systemic conditions additionally raises awareness on the necessity for highly performant strategies for the prevention and management of periodontitis. Periodontal diagnosis is the backbone of a successful periodontal strategy, since prevention and treatment plans depend on the accuracy and precision of the respective diagnostics. Periodontal diagnostics is still founded on clinical and radiological parameters that provide limited therapeutic guidance due to the multifactorial complexity of periodontal pathology, which is why biomarkers have been introduced for the first time in the new classification of periodontal and peri-implant conditions as a first step towards precision periodontics. Since the driving forces of precision medicine are represented by biomarkers and machine learning algorithms, with the lack of periodontal markers validated for diagnostic use, the implementation of a precision medicine approach in periodontology remains in the very initial stage. This narrative review elaborates the unmet diagnostic needs in periodontal diagnostics, the concept of precision periodontics, periodontal biomarkers, and a roadmap toward the implementation of a precision medicine approach in periodontal practice.


Assuntos
Doenças Periodontais , Periodontite , Assistência Odontológica , Humanos , Doenças Periodontais/diagnóstico , Doenças Periodontais/terapia , Periodontia , Periodontite/diagnóstico , Periodontite/terapia , Medicina de Precisão
14.
Artigo em Inglês | MEDLINE | ID: mdl-33807030

RESUMO

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02-1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.


Assuntos
Doenças Ósseas Metabólicas , Osteoporose , Doenças Periodontais , Absorciometria de Fóton , Adulto , Densidade Óssea , Doenças Ósseas Metabólicas/diagnóstico por imagem , Doenças Ósseas Metabólicas/epidemiologia , Humanos , Pessoa de Meia-Idade , Osteoporose/diagnóstico por imagem , Osteoporose/epidemiologia , Doenças Periodontais/epidemiologia , Índice Periodontal , Fatores de Risco , Adulto Jovem
15.
Int J Mol Sci ; 22(7)2021 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-33918456

RESUMO

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship between nonalcoholic fatty liver disease (NAFLD) and periodontal disease has not yet been clarified. Thus, the purpose of this review was to reveal the relationship between NAFLD and periodontal disease based on epidemiological studies, basic research, and immunology. Many cross-sectional and prospective epidemiological studies have indicated that periodontal disease is a risk factor for NAFLD. An in vivo animal model revealed that infection with periodontopathic bacteria accelerates the progression of NAFLD accompanied by enhanced steatosis. Moreover, the detection of periodontopathic bacteria in the liver may demonstrate that the bacteria have a direct impact on NAFLD. Furthermore, Porphyromonas gingivalis lipopolysaccharide induces inflammation and accumulation of intracellular lipids in hepatocytes. Th17 may be a key molecule for explaining the relationship between periodontal disease and NAFLD. In this review, we attempted to establish that oral health is essential for systemic health, especially in patients with NAFLD.


Assuntos
Hepatopatia Gordurosa não Alcoólica/etiologia , Doenças Periodontais/complicações , Animais , Humanos , Imunidade Inata , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Doenças Periodontais/epidemiologia , Linfócitos T/fisiologia
16.
Nutrients ; 13(4)2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-33807159

RESUMO

Vitamin D has been hypothesized to play an important role in preventing the development and progression of periodontal disease, but the underlying immune modulatory mechanisms remain understudied. We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53-81 years. Linear regression was used to examine the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations, a biomarker of vitamin D status, and both salivary and serum CRP concentrations in 567 women from the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study (1997-2000). CRP concentrations were measured with multiplex arrays and transformed for normality using the natural log. Concentrations above and below the limit of detection were included in analysis as right- and left-censored observations. An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03). Further adjustment for percent body fat attenuated this association (-2.48%, 95% CI: -7.88 to 3.24). No significant associations were found between 25(OH)D and serum CRP. Plasma vitamin D concentrations were not associated with salivary or serum CRP concentrations in this cohort of postmenopausal women.


Assuntos
Proteína C-Reativa/metabolismo , Osteoporose/metabolismo , Doenças Periodontais/metabolismo , Vitamina D/análogos & derivados , Tecido Adiposo/metabolismo , Idoso , Idoso de 80 Anos ou mais , Proteína C-Reativa/química , Estudos Transversais , Feminino , Humanos , Inflamação , Pessoa de Meia-Idade , Osteoporose/patologia , Doenças Periodontais/patologia , Saliva/química , Vitamina D/sangue
17.
Biomed Res Int ; 2021: 6688634, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33860050

RESUMO

Objectives: To explore the alterations in maxillary sinus mucosal thickening after extracting teeth with severe periodontal disease using cone-beam computed tomography (CBCT). Methods: 30 patients with severe periodontal disease of maxillary posterior teeth that needed to be extracted and who were radiographically diagnosed with mucosal thickening (MT) in the maxillary sinus participated in the study. CBCT scans were taken before tooth extraction and 2-29 months after tooth extraction. The postextraction follow-up time was divided into two groups: group 1 (<4 months) and group 2 (≥4 months). Dimensions of maxillary sinus MT, including the MT zone length (SL) and the maximum thickness of the MT zone (ST), were evaluated preextraction and postextraction; the residual ridge height (RRH) was evaluated at the sites of extracted and nonextracted teeth. Result: Of the 24 patients with unilateral tooth extraction, there was a statistically significant difference in MT between the extraction and nonextraction sides (p < 0.05). The RRH at the site of the extracted teeth was significantly lower than that of the nonextracted teeth (p < 0.05). MT decreased significantly after tooth extraction on the extraction side but not on the nonextraction side. There was no significant difference between group 1 and group 2 regarding the reduction in mucosal thickness over time. Conclusions: Severe periodontitis can cause MT in the maxillary sinus. The RRH was lower at the sites of extracted teeth. MT reduced quickly by a thorough debridement after tooth extraction in 4 months. MT will not decrease further over time.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Seio Maxilar/diagnóstico por imagem , Membrana Mucosa/diagnóstico por imagem , Membrana Mucosa/patologia , Doenças Periodontais/diagnóstico por imagem , Extração Dentária , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo
18.
Molecules ; 26(7)2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33916013

RESUMO

Periodontal diseases like gingivitis and periodontitis are primarily caused by dental plaque. Several antiplaque and anti-microbial agents have been successfully incorporated into toothpastes and mouthwashes to control plaque biofilms and to prevent and treat gingivitis and periodontitis. The aim of this article was to review recent developments in the antiplaque, anti-gingivitis, and anti-periodontitis properties of some common compounds in toothpastes and mouthwashes by evaluating basic and clinical studies, especially the ones published in the past five years. The common active ingredients in toothpastes and mouthwashes included in this review are chlorhexidine, cetylpyridinium chloride, sodium fluoride, stannous fluoride, stannous chloride, zinc oxide, zinc chloride, and two herbs-licorice and curcumin. We believe this comprehensive review will provide useful up-to-date information for dental care professionals and the general public regarding the major oral care products on the market that are in daily use.


Assuntos
Antissépticos Bucais/análise , Antissépticos Bucais/química , Doenças Periodontais/prevenção & controle , Cremes Dentais/análise , Cremes Dentais/química , Anti-Infecciosos Locais/química , Anti-Infecciosos Locais/farmacologia , Cetilpiridínio/química , Cetilpiridínio/farmacologia , Cloretos/química , Cloretos/farmacologia , Humanos , Doenças Periodontais/etiologia , Doenças Periodontais/patologia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Fluoreto de Sódio/química , Fluoreto de Sódio/farmacologia , Fluoretos de Estanho/análise , Fluoretos de Estanho/química , Fluoretos de Estanho/farmacologia , Compostos de Zinco/química , Compostos de Zinco/farmacologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-33919535

RESUMO

Dental disease is one of the most prevalent chronic diseases worldwide, and its expenditure is continuously increasing. Periodontal disease is increasing as a chronic non-communicable disease in adults and older people. Health screening has been shown to be cost-effective and improves the quality of life through the early detection of diseases. This study aimed to analyze the relationship between national health screening and dental scaling as a preventive service for periodontal disease. The study used sample cohort data from 2002 to 2015 provided by the National Health Insurance Sharing Service in South Korea. A logistic regression analysis of the utilization of dental scaling was performed to identify the independent effects of national health screening. People who underwent health screening showed a higher tendency to undergo dental scaling. Additionally, disparities in utilization according to socioeconomic status were reduced among those who underwent screening. The intervention to extend dental coverage could be more beneficial when combined with health screening, encouraging more people to participate and reducing inequalities in utilization.


Assuntos
Doenças Periodontais , Qualidade de Vida , Adulto , Idoso , Raspagem Dentária , Humanos , Serviços Preventivos de Saúde , República da Coreia/epidemiologia
20.
Res Vet Sci ; 136: 396-407, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33799170

RESUMO

The purpose of the investigation was to determine whether canine gingival margin (GM) plaque is a reliable surrogate for subgingival (SG) plaque from a microbial community (microbiota) perspective. SG and GM plaque samples were collected from 381 dogs visiting pet hospitals in the USA, China and Thailand. Dogs with clinically healthy gingivae through to early periodontitis were included in the study. The samples were subject to next generation Illumina sequence analysis to allow microbiota comparisons to be made between the two plaque sources. Overall, the SG and GM samples indicated commonality via the majority community that were shared between them; health associations led to the identification of some significant taxa-specific differences. GM microbiota exhibited lower variability and diversity and were shown to reflect a sub-population of those associated with SG plaque. Both plaque niches, however, demonstrated similar changes in microbial signatures with health and early periodontal disease and did not indicate divergent trends. The key, most abundant microbiota of GM plaque strongly reflect those observed with SG plaque across health and early periodontitis. Microbiota in plaque from above the gum line may therefore be employed as a biomarker of oral health. This opens up the potential to use plaque, sampled from conscious dogs, to define oral health status and improve the diagnosis, treatments and interventions for periodontal disease.


Assuntos
Bactérias/isolamento & purificação , Placa Dentária/veterinária , Doenças do Cão/microbiologia , Gengiva/microbiologia , Microbiota , Doenças Periodontais/veterinária , Animais , Bactérias/genética , Biodiversidade , China , Estudos de Coortes , Placa Dentária/microbiologia , Cães , Feminino , Sequenciamento de Nucleotídeos em Larga Escala/veterinária , Masculino , Doenças Periodontais/diagnóstico , Doenças Periodontais/microbiologia , Tailândia
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