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1.
Curr Diabetes Rev ; 16(2): 156-164, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31057116

RESUMO

BACKGROUND AND OBJECTIVES: Diabetes mellitus has increased rapidly throughout the world. The objectives of our study were to assess the knowledge and awareness about oral manifestations of diabetes, among type 2 diabetes mellitus patients, their risk for developing oral diseases due to complications associated with diabetes mellitus, and at same time, to perform an oral examination to detect these oral symptoms, if present any, along with the recording of Decayed Missing Filled Teeth Index (DMFT) and Community Periodontal Index (CPI) index. METHODOLOGY: Structured questionnaires consisting of 12 different statements on the knowledge base of oral manifestations of diabetes mellitus were distributed to 447 Type 2 diabetes mellitus patients. Following this oral examination, brushing and dental visit history were noted, and CPI index and DMFT indices were recorded in all the patients. RESULTS: Results showed that the knowledge about oral manifestations of diabetes mellitus was poor with a mean value of 4.92 out of a possible score of 12. Among the study subjects, the average score of men was 4.42 while that of females, was 5.41. These scores, when subjected to statistical analysis, were highly significant. (P value- 0.005) Subjects also showed significantly high DMFT (P value <0.001) and CPI scores (P value- 0.270). CONCLUSION: Our study concluded that there is a significant lack of knowledge about oral manifestations of diabetes mellitus among patients and hence steps have to be taken to increase their awareness through various outreach programs. All health professionals need to work together for promoting better oral health so that oral complications of diabetes can be brought under control.


Assuntos
Diabetes Mellitus Tipo 2/complicações , Doenças da Boca/prevenção & controle , Higiene Bucal , Odontopatias/prevenção & controle , Adulto , Conscientização , Estudos Transversais , Inquéritos de Saúde Bucal , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Boca/diagnóstico , Doenças da Boca/etiologia , Saúde Bucal , Fatores de Risco , Odontopatias/diagnóstico , Odontopatias/etiologia
2.
PLoS One ; 14(12): e0225099, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31851665

RESUMO

INTRODUCTION: Haematopoietic stem cell transplantation (HSCT) recipients are at increased risk for severe infections. This study examined the associations of common oral infections with survival and infectious complications in HSCT recipients. MATERIALS AND METHODS: All autologous and allogeneic HSCT recipients transplanted in the University Hospital of Basel, Switzerland, between 2008 and 2016 and referred to oral infection control pre-HSCT were included in this retrospective case-control study. All patients had a clinical and a panoramic radiological dental examination taken immediately prior to HSCT. Presence of acute or chronic oral foci of infections, decayed, missing or filled tooth index (DMFT) and radiological attachment loss (RAL) were examined. Survival and infections of the subjects were followed up for 6 months post-HSCT. RESULTS: Altogether 341 allogeneic and 125 autologous HSCT recipients were included in the study. Within 6 months post-HSCT, 47 (14%) of the allogeneic and 4 (3%) of the autologous recipients died. Oral foci of infections (acute or chronic), DMFT or periodontitis pre-HSCT were not associated with survival 6 months post-HSCT. Oral foci of infections were also not associated with hospital treated infectious diseases or blood culture positive bacteremia during the 6 month follow-up period. Untreated oral foci of infections were not associated with survival or severe infectious complications within 6 months post-HSCT. CONCLUSION: The results of this study suggest that radical dental interventions to chronic oral infections could be postponed until post-HSCT.


Assuntos
Bacteriemia/etiologia , Doenças Transmissíveis/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Doenças da Boca/etiologia , Adulto , Bacteriemia/mortalidade , Estudos de Casos e Controles , Doenças Transmissíveis/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Boca/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida
3.
Artigo em Alemão | MEDLINE | ID: mdl-31578619

RESUMO

BACKGROUND: In Germany, around four million people are affected by a rare disease, from which 15% show orofacial manifestations. AIM OF THE STUDY: The aim of this cross-sectional study was to determine the oral health-related quality of life of people with rare diseases and to investigate the relationship between oral symptoms, diagnostic delay, and gender. MATERIALS AND METHODS: A questionnaire with open-ended questions, including questions from the validated oral health impact profile (OHIP) G14 questionnaire, was developed to survey the subjective oral health-related quality of life. The questionnaire was sent to 125 German member associations of the umbrella organization of self-help groups. The correlation between OHIP values and the three factors was evaluated using a regression model with a significance level of p = 0.01. RESULTS: In total, 473 participants affected by 96 different rare diseases were included in this analysis. The OHIP value for participants without oral manifestations was 6.54 points lower than for those with oral symptoms (p = 0.001). For oral symptoms, the OHIP increased by 0.080 points (p = 0.014) with each year of diagnostic delay. A connection with sex was not found. CONCLUSION: Regardless of the presence of oral symptoms, people with rare diseases in Germany show a poorer oral health-related quality of life than is known to the normal population. If oral symptoms are present, they show a negative correlation with oral health-related quality of life. On average, it takes 8.37 years for a disease to be correctly diagnosed. The earlier a rare disease is diagnosed, the better the oral health-related quality of life of those affected.


Assuntos
Doenças da Boca/etiologia , Saúde Bucal , Qualidade de Vida , Doenças Raras , Estudos Transversais , Diagnóstico Tardio , Alemanha , Humanos , Doenças Raras/complicações , Inquéritos e Questionários
4.
Stomatologiia (Mosk) ; 98(4): 93-95, 2019.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-31513158

RESUMO

The paper presents a rare clinical case of an infant with KID (Keratitis, Ichthyosis, Deafness) syndrome (about 100 patients reported so far) admitted for histological verification of oral mucosa lesions. Disease pathogenesis defines inadequate reparation and skin and mucosa innate immunity defect leading to higher incidence of bacterial and fungal infections, so the 4-years old girl received treatment for vegetating candidiasis of the oral mucosa for several weeks with no clinical improvement. Initial examination showed that the oral lesions resulted from sharp edges of severely affected carious teeth. Histological study of multifocal biopsy revealed pyogenic granulomas and no signs of SCC. Teeth extraction and symptomatic treatment leaded to significant clinical improvement and some remained mucosal changes may be attributed to syndrome manifestations.


Assuntos
Surdez , Cárie Dentária , Ictiose , Ceratite , Doenças da Boca , Pré-Escolar , Surdez/complicações , Cárie Dentária/etiologia , Feminino , Humanos , Ictiose/complicações , Ceratite/complicações , Doenças da Boca/etiologia , Neoplasias Cutâneas
5.
Lancet ; 394(10194): 261-272, 2019 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-31327370

RESUMO

Oral diseases are a major global public health problem affecting over 3·5 billion people. However, dentistry has so far been unable to tackle this problem. A fundamentally different approach is now needed. In this second of two papers in a Series on oral health, we present a critique of dentistry, highlighting its key limitations and the urgent need for system reform. In high-income countries, the current treatment-dominated, increasingly high-technology, interventionist, and specialised approach is not tackling the underlying causes of disease and is not addressing inequalities in oral health. In low-income and middle-income countries (LMICs), the limitations of so-called westernised dentistry are at their most acute; dentistry is often unavailable, unaffordable, and inappropriate for the majority of these populations, but particularly the rural poor. Rather than being isolated and separated from the mainstream health-care system, dentistry needs to be more integrated, in particular with primary care services. The global drive for universal health coverage provides an ideal opportunity for this integration. Dental care systems should focus more on promoting and maintaining oral health and achieving greater oral health equity. Sugar, alcohol, and tobacco consumption, and their underlying social and commercial determinants, are common risk factors shared with a range of other non-communicable diseases (NCDs). Coherent and comprehensive regulation and legislation are needed to tackle these shared risk factors. In this Series paper, we focus on the need to reduce sugar consumption and describe how this can be achieved through the adoption of a range of upstream policies designed to combat the corporate strategies used by the global sugar industry to promote sugar consumption and profits. At present, the sugar industry is influencing dental research, oral health policy, and professional organisations through its well developed corporate strategies. The development of clearer and more transparent conflict of interest policies and procedures to limit and clarify the influence of the sugar industry on research, policy, and practice is needed. Combating the commercial determinants of oral diseases and other NCDs should be a major policy priority.


Assuntos
Assistência Odontológica/organização & administração , Reforma dos Serviços de Saúde/organização & administração , Doenças da Boca/terapia , Saúde Bucal , Sacarose na Dieta/efeitos adversos , Indústria Alimentícia , Saúde Global , Promoção da Saúde/organização & administração , Humanos , Doenças da Boca/etiologia , Odontologia Preventiva/organização & administração , Saúde Pública
6.
Pan Afr Med J ; 32: 195, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31312307

RESUMO

Introduction: Rare diseases have, in certain cases, oral manifestations. These are often understudied; this helps to limit oral care services to this category of patients. This study aims to determine the epidemiology and clinical features of oral manifestations in patients with rare diseases in our environment. Methods: We conducted a cross-sectional descriptive study in two referral hospitals in Yaoundé over a period of 7 months. Data were collected from patients' medical records, parents' or guardians' interview and oral examination. The threshold significance level was p< 0.05. Results: Oral manifestations associated with rare diseases vary based on the group of conditions, teeth and often have functional consequences. Functional impairment was diagnosed in 97.2% of cases. Patients with deciduous dentition (59.4%) most commonly developed anomalies of tooth shape and position (conicity 7/22 cases, 32%) while patients with permanent teeth most commonly developed carious lesions (7/10 cases, 70%) and anomalies in tooth structure (4/10 cases with dental wear). A significant link between type of tooth, anomalies in tooth structure (p=0.001) and tooth numbers was found (p=0.018). Mastication problems (p=0.023) as well as suction problems (p=0.033) were linked to rare disease patient groups. Conclusion: Oral lesions in patients with rare diseases, although present in our environment, are often neglected. Oral care should be integrated within the basic package of oral health care trainings after the establishment of free or affordable health care for patients with disabilities or with specific needs.


Assuntos
Cárie Dentária/etiologia , Saúde Bucal , Doenças Raras/complicações , Anormalidades Dentárias/etiologia , Adolescente , Camarões , Criança , Pré-Escolar , Estudos Transversais , Cárie Dentária/epidemiologia , Feminino , Humanos , Lactente , Masculino , Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Anormalidades Dentárias/epidemiologia , Dente Decíduo , Adulto Jovem
7.
Eur J Haematol ; 103(4): 300-306, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31240771

RESUMO

OBJECTIVES: Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. METHODS: Two hundred and sixty nine adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with 6-month survival and the progression of the oral disorders within 2 years were examined. RESULTS: Forty HSCT recipients (14.8%) deceased within 6 months post-HSCT. Among the deceased recipients, hyposalivation and caries were more common pre-HSCT than in recipients who survived over 6 months (P < 0.05). HSCT recipients with hyposalivation pre-HSCT had higher risk of death (HR: 1.90, 95% CI:1.00-3.60; P = 0.044) within 6 months post-HSCT compared with recipients without hyposalivation. Hyposalivation pre-HSCT was associated with a higher DMFT index score (P < 0.05) and a smaller number of teeth (P < 0.005) 24 months post-HSCT in comparison with those without hyposalivation. CONCLUSIONS: Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post-HSCT.


Assuntos
Transplante de Células-Tronco Hematopoéticas , Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Xerostomia/epidemiologia , Xerostomia/etiologia , Adulto , Idoso , Feminino , Doença Enxerto-Hospedeiro/diagnóstico , Doença Enxerto-Hospedeiro/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Doenças da Boca/diagnóstico , Prognóstico , Taxa de Sobrevida , Resultado do Tratamento , Xerostomia/diagnóstico , Adulto Jovem
8.
J Craniofac Surg ; 30(7): e643-e645, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31233003

RESUMO

Pterygoid hamular bursitis is a rare craniofacial pain syndrome used to describe palatal and pharyngeal pain due to an enlarged pterygoid hamulus. The pterygoid hamulus is a hook-shaped bony process located bilaterally on each medial pterygoid plate of the sphenoid bone, posterior and medial to each maxillary tuberosity. These processes project downward and anterolaterally; serve as attachment for ligaments and a network of muscles. It can be palpated in patients with a finger palpating the posteromedial to maxillary tuberosity. The pathogenesis is elusive and varies from bursitis of tensor veli palatine, elongated pterygoid hamulus, persistent trauma to the mucosa overlying the pterygoid hamulus. The clinical features include strange chronic sensation, burning, swelling, and erythema of the pterygoid hamulus region. The pain often radiates to pharynx, ipsilateral face and sometimes radiating to temporal region making it difficult to diagnose from headache, temporomandibular disorders, and dental infections like pericoronitis. The anatomical neighboring structures in relation to oropharyngeal region may give a misleading diagnosis to dentist in case of pterygoid hamulus bursitis. The understanding of pterygoid hamulus anatomy and its relation to surrounding structures is necessary to get the correct diagnosis of the inflammatory or traumatic pain in oropharyngeal region.


Assuntos
Bursite/diagnóstico por imagem , Dor Facial/etiologia , Doenças da Boca/etiologia , Osso Esfenoide/patologia , Transtornos da Articulação Temporomandibular/patologia , Bursite/complicações , Feminino , Cefaleia/etiologia , Humanos , Pessoa de Meia-Idade
9.
J Cancer Res Ther ; 15(3): 620-624, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31169230

RESUMO

Background and Objectives: Quid-chewing habit is a common and old tradition in India. It causes various potentially malignant disorders. Therefore, a study was undertaken to analyze the association of various quid-chewing habit patterns and different oromucosal lesions. Materials and Methods: A cross-sectional study was conducted on 150 cases, where all the individuals selected were having quid-chewing habit and oromucosal lesions. Detailed habit history was taken through preformed questionnaire, clinical examination was done, and the lesion was subjected to incisional biopsy and confirmed histopathologically. Results: The male to female ratio of various quid-chewing habit and oromucosal lesions was 9:1. The middle aged were more commonly involved. Of the various types of quids chewed, a combination of processed betel and processed tobacco which is commercially available was used by majority of the individuals. Oral submucous fibrosis (OSMF) was seen in majority of the cases. Interpretation and Conclusion: The present study confirms the association between betel, tobacco, and various lesions such as OSMF, leukoplakia, chewer's mucosa, lichenoid reaction, and chemical burn. It also confirms the strong association of betel to OSMF and tobacco to leukoplakia.


Assuntos
Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Mucosa Bucal/patologia , Tabaco sem Fumaça/efeitos adversos , Adolescente , Adulto , Criança , Estudos Transversais , Feminino , Hábitos , Humanos , Índia/epidemiologia , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/etiologia , Fibrose Oral Submucosa/epidemiologia , Fibrose Oral Submucosa/etiologia , Prevalência , Vigilância em Saúde Pública , Adulto Jovem
10.
Trop Doct ; 49(4): 303-306, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31156067

RESUMO

Diffuse cutaneous leishmaniasis is a rare chronic infectious disease, associated with Leishmania mexicana and L. amazonensis, presenting as multiple non-ulcerative painless nodules, with a tendency to relapse soon after treatment. We report a case of a 56-year-old Mexican woman exhibiting nodular lesions, plaques, crusts and scars involving the whole body. A solitary nodule was present at the junction between hard and soft palates. Diffuse cutaneous leishmaniasis is a disfiguring disease resulting in severe scarring if untreated.


Assuntos
Leishmania mexicana/fisiologia , Leishmaniose Tegumentar Difusa/complicações , Leishmaniose Tegumentar Difusa/diagnóstico , Doenças da Boca/etiologia , Doenças da Boca/parasitologia , Palato/patologia , Feminino , Humanos , Leishmaniose Tegumentar Difusa/parasitologia , Leishmaniose Tegumentar Difusa/patologia , México , Pessoa de Meia-Idade , Palato/parasitologia , Recidiva
11.
Transplant Proc ; 51(4): 1248-1250, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31101207

RESUMO

Drug-induced immunosuppression can predispose kidney transplant patients to different complications including chronic infections and oral lesions. We surveyed oral hygiene habits and conducted detailed periodontal examinations for status assessment. Appropriate oral hygiene and regular professional control can reduce number and severity of complications, which might be preventive for transplant rejection.


Assuntos
Imunossupressão/efeitos adversos , Transplante de Rim/efeitos adversos , Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Saúde Bucal , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
12.
Curr Gastroenterol Rep ; 21(7): 31, 2019 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-31098819

RESUMO

PURPOSE OF REVIEW: Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) represent a complex array of disease processes with variable epidemiologic penetrance, genetic antecedents, and phenotypic presentations. The purpose of this review is to provide an overview of primary and secondary EIMs as well as salient treatment strategies utilized. RECENT FINDINGS: While the genetic antecedents remain incompletely understood, the treatment armamentarium for EIMs has expanded with new pharmaceutical drug classes that effectively treat IBD. EIMs are an increasingly recognized complication of IBD that require prompt recognition, multidisciplinary management, and a multifaceted therapeutic approach. This review highlights the complexities and ramifications of EIM management and offers therapeutic guidance.


Assuntos
Doenças Inflamatórias Intestinais/complicações , Oftalmopatias/diagnóstico , Oftalmopatias/etiologia , Oftalmopatias/terapia , Humanos , Doenças Inflamatórias Intestinais/epidemiologia , Doenças da Boca/diagnóstico , Doenças da Boca/etiologia , Doenças da Boca/terapia , Doenças Musculoesqueléticas/diagnóstico , Doenças Musculoesqueléticas/etiologia , Doenças Musculoesqueléticas/terapia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Dermatopatias/terapia
13.
J Oral Pathol Med ; 48(6): 425-432, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30883922

RESUMO

INTRODUCTION: Shammah is a form of smokeless tobacco commonly used in the Arabian Peninsula. The data on the harmful effects of shammah on oral health, particularly oral malignancies, are scarce. The aim of this review was to explore the association between shammah use and development of oral potentially malignant disorders (OPMD) and/or oral cancer. MATERIALS AND METHODS: PubMed, EMBASE, Scopus, Web of Science and grey literature from January 1990 up to and including April 2018 were searched. Two independent reviewers performed the study selection according to eligibility criteria. RESULTS: A total of 10 studies that met the eligibility criteria were included. The odds of developing OPMD and/or oral cancer in relation to shammah use varied, with one study reporting a 39 increased risk (39, 95% CI: 14-105). The associated increased risk was relatively low among those that have stopped using shammah and ranged from threefold (3.65; 95% CI: 1.40-9.50) to 12-fold (12.6; 95% CI: 3.3-48.2). CONCLUSION: Shammah use seems to increase the risk of development of OPMD and/or oral cancer.


Assuntos
Doenças da Boca/etiologia , Neoplasias Bucais/etiologia , Tabaco sem Fumaça/efeitos adversos , Humanos , Mastigação , Oriente Médio , Saúde Bucal
14.
Niger J Clin Pract ; 22(3): 439-441, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30837436

RESUMO

The harmful effects of khat chewing on the oral mucosa membrane are still uncertain. Verruca vulgaris (common warts) is a benign lesion of skin and mucous membranes and can be caused by human papillomavirus. The lesions are typically self-limited but may vary in size and number. The occurrence on the floor of mouth is extremely rare. To the best of our knowledge, there are few number of oral lesions reported in connection with khat users. This case report shows that the chronic khat chewing has contributed to the development of verruca vulgaris warts that were confined to the chewing side of the mouth. A rare case of verruca vulgaris of the floor of mouth occurring in a 27-year-old Yamani male is presented with a discussion on etiopathogenesis and the treatment methods. Verruca vulgaris must be remembered in the differential diagnosis of the floor of mouth lesions, and surgical treatment may provide satisfactory outcomes.


Assuntos
Catha/efeitos adversos , Doenças da Boca/etiologia , Doenças da Boca/cirurgia , Mucosa Bucal/virologia , Verrugas/etiologia , Verrugas/cirurgia , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Mastigação , Doenças da Boca/diagnóstico , Soalho Bucal/virologia , Folhas de Planta/efeitos adversos , Verrugas/diagnóstico
15.
J Oral Pathol Med ; 48(5): 406-412, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30860627

RESUMO

BACKGROUND: Despite the frequency of oral involvement, there are unexpectedly few studies of either on the oral manifestations of pemphigus or their long-term management, and diagnostic delay in Dentistry is frequent. METHODS: We have examined outcome of patients presenting with predominantly oral pemphigus vulgaris (PV). Ninety-eight subjects were followed up for 85.12 months and treated with systemic steroids: 48 of them received adjunctive therapy with azathioprine, 16 with rituximab, 13 with mycophenolate mofetil, three with immunoglobulin and one with dapsone. RESULTS: Clinical remission was achieved in 80 patients (84.21%); 39 of them were off therapy and 41 on therapy. Fifteen patients were not in remission, having been under systemic therapy for 72.16 months. Sixty-nine patients developed detectable adverse effects. Two fatal outcomes were recorded. Each additional year of steroid therapy ensured 47% chance of developing 1 or 2 side effects, and 64% chance of developing more than 3 (ORs 1.47, CI 1.162-1.903; ORs 1.64, CI 1.107-2.130, respectively). CONCLUSION: In one of the largest available cohort with the longest follow-up ever reported, we observed that the management remains need-based and patient-specific, still relying on systemic corticosteroids.


Assuntos
Doenças da Boca/tratamento farmacológico , Pênfigo/tratamento farmacológico , Corticosteroides/uso terapêutico , Adulto , Idoso , Diagnóstico Tardio , Feminino , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Doenças da Boca/etiologia , Pênfigo/complicações , Estudos Retrospectivos , Resultado do Tratamento
17.
Int J Med Sci ; 16(2): 253-263, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30745806

RESUMO

Aims: Temporomandibular disorders (TMD) represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Rheumatoid Arthritis (RA) is an autoimmune polyarthritis characterized by the chronic inflammation of synovial joints and oral implications such as hyposalivation, difficulty in swallowing and phoning, feeling of burning mouth, increased thirst, loss of taste or unpleasant taste and smell, dental sensitivity. The aim of this observational study was to investigate the prevalence of TMD symptoms and signs as well as oral implications in patients with Early Rheumatoid Arthritis (ERA), that is a RA diagnosed within 12 months, compared with a control group. Methods: The study group included 52 ERA patients (11 men, 41 women) diagnosed according to the 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis. A randomly selected group of 52 patients not affected by this disease, matched by sex and age, served as the control group. The examination for TMD signs and symptoms was based on the standardized Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) by means of a questionnaire and through clinical examination. Results: Regarding the oral kinematics, the left lateral excursion of the mandible was restricted in statistically significant way in ERA patients (p=0.017). The endfeel values were significantly increased in ERA group (p=0.0017), thus showing the presence of a higher muscle contracture. On the other side, the study group complained less frequently (67.3%) of TDM symptoms (muscle pain on chewing, pain in the neck and shoulders muscles, difficulty in mouth opening, arthralgia of TMJ, tinnitus) than controls (90.4%) (χ2= 8.301 p=0.0039). The presence of TMJ noises was significantly lower in the study group (χ2= 3.869 p=0.0049), as well as presence of opening derangement (χ2= 14.014 p=0.0002). The salivary flow was significantly decreased in the study group respect to the control one (p<0.0001). Conclusions: The data collected show a weak TMJ kinematic impairment, a paucisymptomatic muscle contracture (positive endfeel) and a remarkable reduction of salivary flow in ERA patients. Myofacial pain (MP) evoked by palpation was more frequent and severe in the control group than in the study one, this result being highly significant.


Assuntos
Artrite Reumatoide/complicações , Doenças da Boca/epidemiologia , Transtornos da Articulação Temporomandibular/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Criança , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/etiologia , Transtornos da Articulação Temporomandibular/etiologia , Adulto Jovem
18.
Head Neck Pathol ; 13(1): 33-46, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30693453

RESUMO

When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Reactive and inflammatory lesions can create a yellow hue due to purulence, necrosis, and calcification. Some systemic diseases are known to deposit yellow bi-products such as amyloid or bilirubin into the oral mucosa of an affected person, and while not always yellow, unusual entities like verruciform xanthoma and granular cell tumor fall under the umbrella of yellow lesions given their occasional propensity to demonstration the color. This chapter aims to explore the unique group that is yellow lesions presenting in the oral mucosa.


Assuntos
Doenças da Boca/etiologia , Doenças da Boca/patologia , Mucosa Bucal/patologia , Humanos
19.
Eur J Haematol ; 102(4): 351-356, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30632215

RESUMO

OBJECTIVES: The purpose of this study was to compare the prevalence of common oral diseases between allogeneic haematopoietic stem cell transplantation (HSCT) recipients and healthy controls. MATERIALS AND METHODS: A total of 143 adult allogeneic HSCT recipients who were treated for haematological malignancies between 2008 and 2016 were included in the study. The HSCT recipients were age and sex matched with healthy controls. A dental examination was performed on the HSCT recipients prior to HSCT. Differences in stimulated saliva flow rate (SSFR), decayed, missing and filled teeth (DMFT) index, number of teeth, number of caries lesions, and measures of current or previous periodontitis (radiological attachment loss >3 mm or probing pocket depth ≥4 mm) between HSCT recipients and controls were examined. RESULTS: Stimulated saliva flow rate, DMFT index and the number of caries lesions were poorer in the HSCT recipients pre-HSCT compared to controls (all P-values <0.05). No statistically significant differences in the measures of current or previous periodontitis were observed. CONCLUSIONS: Stimulated saliva flow rate was low and caries was common in HSCT recipients prior to HSCT. Efficient preventive strategies are important in order to maintain the oral health of these patients.


Assuntos
Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Doenças da Boca/diagnóstico , Doenças da Boca/etiologia , Adulto , Estudos de Casos e Controles , Feminino , Neoplasias Hematológicas/complicações , Neoplasias Hematológicas/diagnóstico , Neoplasias Hematológicas/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Transplante Homólogo , Adulto Jovem
20.
Head Neck Pathol ; 13(1): 16-24, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30671762

RESUMO

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Included in the discussion are frictional keratoses, irritant contact stomatitis, and smokeless tobacco keratoses. Leukoedema and hereditary genodermatoses that may enter in the clinical differential diagnoses of frictional keratoses including white sponge nevus and hereditary benign intraepithelial dyskeratosis will be reviewed. Many products can result in contact stomatitis. Dentrifice-related stomatitis, contact reactions to amalgam and cinnamon can cause keratotic lesions. Each of these lesions have microscopic findings that can assist in patient management.


Assuntos
Ceratose/patologia , Doenças da Boca/patologia , Mucosa Bucal/patologia , Humanos , Ceratose/etiologia , Doenças da Boca/etiologia , Tabaco sem Fumaça/efeitos adversos
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