Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 3.436
Filtrar
1.
An Bras Dermatol ; 94(5): 521-526, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777351

RESUMO

BACKGROUND: The use of monoethanolamine oleate 5% is effective for the treatment of vascular malformations with low blood flow. OBJECTIVES: To report a case series of vascular malformations in the mouth and oral cavity treated with monoethanolamine oleate 5%. METHODS: A retrospective descriptive study was performed in electronic patient charts covering seven years. Patient demographics, diagnostic resources, lesion site, size, and number of applications of monoethanolamine oleate 5% were collected. RESULTS: A total of 21 vascular malformations were recorded, located mostly on the lower lip (52.3%) and resolved in a single application in 14 patients. The authors found 19 patients treated with sclerotherapy. Thirteen were women and six were men, with a mean age of 61 years. STUDY LIMITATION: Small sample size. CONCLUSIONS: Sclerotherapy is an effective treatment for vascular malformations of the lips and oral cavity, with resolution after only one or two applications (n=16).


Assuntos
Doenças da Boca/terapia , Ácidos Oleicos/administração & dosagem , Soluções Esclerosantes/administração & dosagem , Escleroterapia/métodos , Malformações Vasculares/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estética , Feminino , Humanos , Injeções Intralesionais , Lábio/irrigação sanguínea , Lábio/patologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/patologia , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Malformações Vasculares/patologia , Adulto Jovem
2.
Rev Med Suisse ; 15(672): 2131-2136, 2019 Nov 20.
Artigo em Francês | MEDLINE | ID: mdl-31746569

RESUMO

Many diseases affect the oral cavity. Therefore, the mouth is an organ that internists should observe carefully. Hereafter we present five illustrations of oral semiology that reflect a systemic condition: a strawberry tongue, an ulceration, a labial lesion, a gingival hyperplasia and a gingival hyperpigmentation. Each time, a differential diagnosis is to be considered, potentially allowing the identification of severe diseases.


Assuntos
Medicina Interna/métodos , Doenças da Boca/complicações , Doenças da Boca/diagnóstico , Boca/patologia , Diagnóstico Diferencial , Humanos , Doenças da Boca/patologia , Mucosa Bucal/patologia
3.
An Bras Dermatol ; 94(4): 388-398, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644609

RESUMO

Paraneoplastic pemphigus is a rare and severe autoimmune blistering disease characterized by mucocutaneous lesions associated with benign and malignant neoplasms. Diagnostic criteria include the presence of chronic mucositis and polymorphic cutaneous lesions with occult or confirmed neoplasia; histopathological analysis exhibiting intraepidermal acantholysis, necrotic keratinocytes, and vacuolar interface dermatitis; direct immunofluorescence with intercellular deposits (IgG and C3) and at the basement membrane zone (IgG); indirect immunofluorescence with intercellular deposition of IgG (substrates: monkey esophagus and simple, columnar, and transitional epithelium); and, autoreactivity to desmogleins 1 and 3, desmocollins 1, 2, and 3, desmoplakins I and II, envoplakin, periplakin, epiplakin, plectin, BP230, and α-2-macroglobulin-like protein 1. Neoplasias frequently related to paraneoplastic pemphigus include chronic lymphocytic leukemia, non-Hodgkin lymphoma, carcinomas, Castleman disease, thymoma, and others. Currently, there is no standardized treatment for paraneoplastic pemphigus. Systemic corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine, rituximab, cyclophosphamide, plasmapheresis, and intravenous immunoglobulin have been used, with variable outcomes. Reported survival rates in 1, 2, and 5 years are 49%, 41%, and 38%, respectively.


Assuntos
Síndromes Paraneoplásicas/patologia , Síndromes Paraneoplásicas/terapia , Pênfigo/patologia , Pênfigo/terapia , Autoanticorpos/imunologia , Eritema/diagnóstico , Eritema/patologia , Humanos , Doenças da Boca/diagnóstico , Doenças da Boca/patologia , Síndromes Paraneoplásicas/diagnóstico , Síndromes Paraneoplásicas/imunologia , Pênfigo/diagnóstico , Pênfigo/imunologia , Pele/patologia
4.
Artigo em Inglês | MEDLINE | ID: mdl-31618374

RESUMO

HPV clinical manifestations have their characteristics modified by the use of combined antiretroviral therapy (cART), although its incidence is unaffected by cART. We report an unusual presentation of oral HPV infection and discuss an effective treatment for disseminated HPV lesions. A 52-year-old male of Asian-origin, HIV-seropositive, presented with extensive nodular lesions throughout the oral mucosa extending to the oropharyngeal region. Biopsy followed by histopathological examination and HPV genotyping were performed. The treatment was initiated with topical application of podophyllin and trichloroacetic acid. HPV lesions in oral mucosa are generally easy to handle. Extensive lesions can make it difficult to choose an effective treatment that meets the patient's particularities and medication availability.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/patologia , Antirretrovirais/uso terapêutico , Doenças da Boca/patologia , Infecções por Papillomavirus/patologia , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Boca/tratamento farmacológico , Infecções por Papillomavirus/tratamento farmacológico , Podofilina/uso terapêutico , Ácido Tricloroacético/uso terapêutico
7.
An. bras. dermatol ; 94(4): 388-398, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1038294

RESUMO

Abstract: Paraneoplastic pemphigus is a rare and severe autoimmune blistering disease characterized by mucocutaneous lesions associated with benign and malignant neoplasms. Diagnostic criteria include the presence of chronic mucositis and polymorphic cutaneous lesions with occult or confirmed neoplasia; histopathological analysis exhibiting intraepidermal acantholysis, necrotic keratinocytes, and vacuolar interface dermatitis; direct immunofluorescence with intercellular deposits (IgG and C3) and at the basement membrane zone (IgG); indirect immunofluorescence with intercellular deposition of IgG (substrates: monkey esophagus and simple, columnar, and transitional epithelium); and, autoreactivity to desmogleins 1 and 3, desmocollins 1, 2, and 3, desmoplakins I and II, envoplakin, periplakin, epiplakin, plectin, BP230, and α-2-macroglobulin-like protein 1. Neoplasias frequently related to paraneoplastic pemphigus include chronic lymphocytic leukemia, non-Hodgkin lymphoma, carcinomas, Castleman disease, thymoma, and others. Currently, there is no standardized treatment for paraneoplastic pemphigus. Systemic corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine, rituximab, cyclophosphamide, plasmapheresis, and intravenous immunoglobulin have been used, with variable outcomes. Reported survival rates in 1, 2, and 5 years are 49%, 41%, and 38%, respectively.


Assuntos
Humanos , Síndromes Paraneoplásicas/patologia , Síndromes Paraneoplásicas/terapia , Pênfigo/imunologia , Pênfigo/patologia , Pênfigo/terapia , Síndromes Paraneoplásicas/imunologia , Pele/patologia , Autoanticorpos/imunologia , Pênfigo/diagnóstico , Eritema/diagnóstico , Eritema/patologia , Doenças da Boca/diagnóstico , Doenças da Boca/patologia
8.
Pediatr Dermatol ; 36(5): 730-731, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31177575

RESUMO

Pemphigus vulgaris (PV) is an autoimmune intraepithelial bullous disease that affects the skin and mucous membranes. Typically, the management of PV is challenging, with systemic corticosteroids being the mainstay of treatment. We describe the case of a 14-year-old girl who was diagnosed with oral PV and successfully treated with topical corticosteroids alone. This case details a pediatric mucosal PV case successfully managed solely with topical corticosteroids.


Assuntos
Fluocinonida/uso terapêutico , Glucocorticoides/uso terapêutico , Doenças da Boca/tratamento farmacológico , Pênfigo/tratamento farmacológico , Administração Tópica , Adolescente , Feminino , Humanos , Doenças da Boca/patologia , Pênfigo/patologia
9.
J Formos Med Assoc ; 118(9): 1299-1307, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31202497

RESUMO

BACKGROUND/PURPOSE: Our previous studies found relatively higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia in patients with different types of oral mucosal diseases. This study evaluated whether patients with oral precancerous lesions (oral precancer patients) had significantly higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects. METHODS: The complete blood count, serum iron, vitamin B12, folic acid, and homocysteine levels in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects were measured and compared. RESULTS: We found significantly lower mean serum iron (for women only), vitamin B12, and folic acid levels and a significantly higher mean serum homocysteine level in oral precancer patients than in healthy control subjects (all P-values < 0.05). Moreover, 131 oral precancer patients had significantly higher frequencies of blood hemoglobin (3.1%), vitamin B12 (43.5%), and folic acid (46.6%) deficiencies and hyperhomocysteinemia (22.1%) than 131 healthy control subjects (all P-values < 0.05). Of 131 oral precancer patients, lower mean serum folic acid levels were found in 87 cigarette smokers than in 44 non-smokers (P = 0.002), in 26 smokers consuming > 20 cigarettes per day than in 61 smokers consuming ≤ 20 cigarettes per day (P = 0.024), and in 52 betel quid chewers than in 79 non-chewers (P = 0.051). CONCLUSION: There are significantly higher frequencies of anemia, serum vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in oral precancer patients than in healthy control subjects.


Assuntos
Autoanticorpos/sangue , Hiper-Homocisteinemia/sangue , Leucoplasia Oral/sangue , Doenças da Boca/sangue , Adulto , Idoso , Anemia/etiologia , Estudos de Casos e Controles , Índices de Eritrócitos , Feminino , Ácido Fólico/sangue , Deficiência de Ácido Fólico/sangue , Hematínicos , Hemoglobinas/análise , Humanos , Ferro/sangue , Masculino , Pessoa de Meia-Idade , Doenças da Boca/patologia , Células Parietais Gástricas/imunologia , Fatores Sexuais , Taiwan , Vitamina B 12/sangue , Deficiência de Vitamina B 12/sangue
10.
Stomatologiia (Mosk) ; 98(2): 71-75, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31089125

RESUMO

OBJECTIVE Based on the data available in modern literature, to conduct a study on the epidemiology, etiology and pathogenesis of bullous lesions of the oral mucosa (pemphigus vulgaris, pemphigoid bullosa, lichen ruber planus). MATERIAL AND METHODS: The article is based on the study of materials of foreign and domestic research databases Pubmed and Elibrary. Used literature data over the past 15 years. RESULTS: According to domestic and foreign studies, among dermatological diseases, the most frequently detected diseases are: lichen ruber planus, pemphigoid bullosa and pemphigus vulgaris. The initial signs of these diseases are often neglected, both in patients and doctors, which leads to irreversible changes and severe course of the pathological process. In this connection, the number of patients with these lesions of the oral mucosa increases every year in all countries of the world. Bullous lesions of the oral mucosa are inflammatory and destructive diseases characterized mainly by recurrent course, variety of clinical manifestations, resistance to various therapeutic drugs. The specific features of the course of these diseases are explained both by the anatomical and physiological features of the oral mucosa, and by the etiologic and pathogenetic mechanisms of development. Currently, autoimmune processes play a leading role in the genesis of diseases, developing in response to changes in the antigenic structure of epidermal and epithelial cells under the influence of various damaging agents. CONCLUSION: Thanks to the study, it was found that currently there are no data confirming the presence of microbial contamination of the tissues of the oral mucosa in the pathology under study. Not enough information on the factors of the immune response, in particular, on proinflammatory cytokines in the tissues of the oral mucosa.


Assuntos
Doenças da Boca , Penfigoide Bolhoso , Pênfigo , Vesícula , Humanos , Doenças da Boca/diagnóstico , Doenças da Boca/epidemiologia , Doenças da Boca/patologia , Mucosa Bucal , Penfigoide Bolhoso/diagnóstico , Penfigoide Bolhoso/epidemiologia , Penfigoide Bolhoso/patologia
11.
Dermatol Online J ; 25(4)2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-31046906

RESUMO

Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area; oral mucosal lesions are extremely rare. A 52-year-old woman presented for evaluation of an 8-year history of a persistent whitish plaque in the buccal mucosa. Intraoral examination revealed multiple elevated whitish plaques diffusely distributed in the buccal mucosa associated with an area of tissue atrophy. Although both leukoplakia and lichen planus were considered, incisional biopsy and later, full excision confirmed the histopathological diagnosis of oral LS. After 6 months of follow-up, there are no clinical signs of relapse. This case highlights the importance of clinical and histopathological findings for the correct diagnosis and treatment of oral LS.


Assuntos
Líquen Escleroso e Atrófico/patologia , Doenças da Boca/patologia , Biópsia , Doença Crônica , Feminino , Humanos , Líquen Escleroso e Atrófico/cirurgia , Pessoa de Meia-Idade , Doenças da Boca/cirurgia , Mucosa Bucal/patologia
12.
Rev Assoc Med Bras (1992) ; 65(3): 330-332, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30994828

RESUMO

Vitiligo is the most common depigmenting, chronic acquired disease of the skin and mucosa. However, vitiligo of an unclassified type and mucosal subtype affecting only one area of the mucosa is considered quite uncommon. The diagnosis of vitiligo, regardless of its type, is clinical. Nonetheless, a device that allows the visualization of the tissue fluorescence may be useful for confirming the diagnosis. We present the use of wide-field optical fluorescence device for complementary examination and diagnosis of unusual cases of mucosal vitiligo located only in angles of the mouth.


Assuntos
Doenças da Boca/diagnóstico por imagem , Mucosa Bucal/diagnóstico por imagem , Imagem Óptica/métodos , Vitiligo/diagnóstico por imagem , Fluorescência , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Boca/patologia , Mucosa Bucal/patologia , Imagem Óptica/instrumentação , Vitiligo/patologia
14.
Med Oral Patol Oral Cir Bucal ; 24(2): e271-e280, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30818322

RESUMO

BACKGROUND: We aim to evaluate the presence of histological artefacts in the surgical margins of human oral fibro-epithelial hyperplasias excised with lasers of different wavelengths, and also electrosurgical scalpel and cold scalpel. Moreover, we aim to determine if some of these instruments could impair the normal histological diagnosis of these lesions. MATERIAL AND METHODS: We included 130 consecutive surgical samples of 80 females and 50 males (mean age of 53.82±16.55) with a histological diagnosis of an oral benign fibrous-epithelial hyperplasias. The samples were categorized into 6 groups according to the type of instrument used: CO2 laser group, diode laser group, Er:YAG laser group, Nd:YAG laser group, electrosurgical scalpel group and cold scalpel group. Histological instrument-induced changes were microscopic evaluated and related with clinical and pathological variables. RESULTS: The instrument with highest tissue damage extension (TDE) was the electrosurgical scalpel (1002.2µm±434.92), followed by diode laser (913.73 µm±322.45), Nd:YAG (899.83µm±327.75), CO2 laser (538.37µm±170.50), Er:YAG laser (166.47µm±123.85), and at last with fewer alterations the cold scalpel group (2.36µm±7.27) (P < 0.001). The most regular incision was observed in CO2 laser group, followed by Er:YAG laser, Nd:YAG laser, electrosurgical scalpel and diode laser group with the less regular incision using cold scalpel as comparison (P < 0.001). A correlation was found between the incision score and TDE (P < 0.001). Regarding histological diagnosis, no case showed any limitation of diagnosis related with the use of any instrument evaluated. CONCLUSIONS: Our results suggest that lasers can be used for the excision of oral benign fibrous-epithelial hyperplasias, without hispathological diagnosis limitations, as long as the physical properties of each laser are known and respected. Er:YAG laser have shown to be a laser with few tissue damage extension and with good incision regularity, been a possible instrument of choice for the surgical removal of these lesions.


Assuntos
Eletrocirurgia/métodos , Hiperplasia/patologia , Lasers de Gás/uso terapêutico , Lasers Semicondutores/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Margens de Excisão , Doenças da Boca/patologia , Procedimentos Cirúrgicos Bucais/métodos , Adulto , Idoso , Feminino , Humanos , Hiperplasia/cirurgia , Terapia a Laser/instrumentação , Terapia a Laser/métodos , Masculino , Pessoa de Meia-Idade , Boca/patologia , Boca/cirurgia , Doenças da Boca/cirurgia , Mucosa Bucal/patologia , Mucosa Bucal/cirurgia , Procedimentos Cirúrgicos Bucais/instrumentação , Palato Duro/patologia , Palato Duro/cirurgia , Estudos Retrospectivos , Instrumentos Cirúrgicos , Língua/patologia , Língua/cirurgia
15.
ScientificWorldJournal ; 2019: 2357013, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30853862

RESUMO

Aim: To determine the epidemiological profile of oral diseases in a marginal urban Peruvian population. Methods: A 9-year retrospective study was conducted, analysing 18,639 clinical records from the María Auxiliadora Hospital between 2006 and 2015 with diagnoses of oral lesions using ICD-10 criteria. Clinical records were analysed for sex, tumour, periapical abscess and sinus, cysts of the oral region, other lesions of the oral mucosa and cavity, gingivitis and periodontal disease, dentofacial anomalies, diseases of pulp, etc. Results: Of 18,639 cases, the prevalence was higher in women for the following pathologies: unspecified dental caries (30.6%); impacted tooth in the category of disorders of tooth development and eruption (2.0%); pulpitis (6.8%) in the category of diseases of pulp and periapical tissues; temporomandibular joint (TMJ) disorders (1.5%) in the category of dentofacial anomalies; acute gingivitis (7.5%); radicular cyst (0.3%) in the category of cysts of the oral region; and periapical abscess without sinus (2.0%). Conclusions: We found a significant association between sex and different types of dental caries, disturbances in tooth eruption, diseases of pulp and periapical tissues, and dentofacial anomalies. The study also shows a statistically significant association between sex and gingivitis, periodontal disease, and periodontal abscess and sinus.


Assuntos
Doenças da Boca/epidemiologia , Boca/patologia , Estudos Transversais , Feminino , Humanos , Masculino , Doenças da Boca/classificação , Doenças da Boca/patologia , Peru/epidemiologia , Estudos Retrospectivos
16.
Dis Markers ; 2019: 8761860, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30906485

RESUMO

Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Saliva is a biofluid that generated a high interest among researchers due to its multiple advantages over other body fluids. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. It is expected that in the future specific guidelines and results regarding the salivary diagnostics are to be available, together with high-sensitivity and specificity tests for multiple systemic and oral diseases.


Assuntos
Doenças Cardiovasculares/metabolismo , Doenças da Boca/metabolismo , Saliva/metabolismo , Biomarcadores/metabolismo , Doenças Cardiovasculares/genética , Doenças Cardiovasculares/patologia , Humanos , Técnicas de Diagnóstico Molecular/métodos , Doenças da Boca/genética , Doenças da Boca/patologia
17.
In Vivo ; 33(2): 289-296, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30804105

RESUMO

BACKGROUND: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. MATERIALS AND METHODS: Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. RESULTS: This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. CONCLUSION: Although variability in findings between individual studies exists, it justifies the conclusion that oxidative stress is a significant process in the oral mucosal diseases pathogenesis.


Assuntos
Doenças da Boca/metabolismo , Mucosa Bucal/metabolismo , Neoplasias Bucais/metabolismo , Estresse Oxidativo/genética , Radicais Livres/metabolismo , Humanos , Doenças da Boca/patologia , Mucosa Bucal/patologia , Neoplasias Bucais/patologia , Espécies Reativas de Oxigênio/metabolismo
19.
Head Neck Pathol ; 13(1): 33-46, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30693453

RESUMO

When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Reactive and inflammatory lesions can create a yellow hue due to purulence, necrosis, and calcification. Some systemic diseases are known to deposit yellow bi-products such as amyloid or bilirubin into the oral mucosa of an affected person, and while not always yellow, unusual entities like verruciform xanthoma and granular cell tumor fall under the umbrella of yellow lesions given their occasional propensity to demonstration the color. This chapter aims to explore the unique group that is yellow lesions presenting in the oral mucosa.


Assuntos
Doenças da Boca/etiologia , Doenças da Boca/patologia , Mucosa Bucal/patologia , Humanos
20.
Head Neck Pathol ; 13(1): 80-90, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30693456

RESUMO

Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Mechanisms of infection, epidemiology, clinical presentations, histologic features, and differential diagnoses of the HPV-related oral pathologies are discussed. Current concepts of viral transmission, especially as pertaining to lesions in pediatric patients, and the impacts of HPV vaccination are reviewed.


Assuntos
Doenças da Boca/patologia , Doenças da Boca/virologia , Mucosa Bucal/patologia , Mucosa Bucal/virologia , Infecções por Papillomavirus/patologia , Humanos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA