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1.
Indian J Ophthalmol ; 69(4): 985-986, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33727473

RESUMO

A 32-year-old man with a clear and compact graft following a penetrating keratoplasty 6 years back, developed an episode of acute graft rejection, coinciding with the COVID-19 disease. Subsequent to the infection with the novel coronavirus, he developed symptoms of acute graft rejection concurrent with the development of respiratory distress and peak systemic symptoms. This was the phase of cytokine storm as evidenced by the raised inflammatory markers in his blood tests. Such a case of acute corneal graft rejection coinciding with SARS-CoV-2 infection has been reported only once in the literature and this unique association needs to be researched further.


Assuntos
/diagnóstico , Doenças da Córnea/diagnóstico , Infecções Oculares Virais/diagnóstico , Rejeição de Enxerto/diagnóstico , Ceratoplastia Penetrante , Doença Aguda , Adulto , /virologia , Extração de Catarata , Doenças da Córnea/tratamento farmacológico , Doenças da Córnea/virologia , Citocinas/sangue , Infecções Oculares Virais/tratamento farmacológico , Infecções Oculares Virais/virologia , Glucocorticoides/uso terapêutico , Rejeição de Enxerto/tratamento farmacológico , Rejeição de Enxerto/virologia , Humanos , Incidência , Mediadores da Inflamação/sangue , Implante de Lente Intraocular , Masculino , Pneumonia Viral/sangue , Prednisolona/uso terapêutico , Acuidade Visual
2.
Ophthalmologe ; 118(4): 404-412, 2021 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-33683425

RESUMO

OBJECTIVE: The aim of simple limbal epithelial transplantation (SLET) is the regeneration of the corneal surface in unilateral complete limbal stem cell deficiency (LSCD). INDICATIONS: SLET is indicated for unilateral complete LSCD. CONTRAINDICATIONS: Contraindications include bilateral LSCD, severe corneal thinning, pronounced keratoconjunctivitis sicca, chronic inflammatory condition of the ocular surface, malposition of the eyelids and pronounced adhesions of the conjunctiva with trichiasis. SURGICAL TECHNIQUE: A 1­h biopsy is obtained from the superior limbus of the healthy donor eye. A 360° peritomy is performed on the LSCD eye and pannus tissue covering the cornea is removed. An amniotic membrane (AM) is glued to the corneal surface with fibrin. The donor tissue is then divided into 8-10 small pieces, which are placed on the AM sparing the visual axis and fixed by fibrin glue. A contact lens is placed on the eye. A surgical video, which is available online, shows the surgical technique in detail. FOLLOW-UP: Examinations are necessary within the first postoperative week and 1 month after SLET, then every 3 months within the first postoperative year. Antibiotic eye drops should be applied 5 times daily until complete epithelialization. Topical steroids should be applied 6 times daily in the early postoperative period and can be tapered thereafter. Artificial tears can improve epithelial healing. Ideally, all eye drops should be preservative-free. The contact lens can be removed after 7-10 days. The AM dissolves within a few weeks. An epithelialization of the corneal surface can be observed by the second postoperative week. EVIDENCE: A recent systematic review reported a stable epithelialized corneal surface in 78% of SLET cases after 1.5 years. An improvement of visual acuity of at least two lines was found in 69% of SLET cases.


Assuntos
Doenças da Córnea , Epitélio Anterior , Queimaduras Oculares , Limbo da Córnea , Doenças da Córnea/cirurgia , Epitélio Anterior/cirurgia , Humanos , Limbo da Córnea/cirurgia , Transplante de Células-Tronco , Transplante Autólogo
3.
Nat Commun ; 12(1): 1544, 2021 03 09.
Artigo em Inglês | MEDLINE | ID: mdl-33750806

RESUMO

Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis.


Assuntos
Lentes de Contato Hidrofílicas , Córnea/fisiologia , Eletrodiagnóstico/métodos , Sensação/fisiologia , Visão Ocular/fisiologia , Doenças da Córnea/diagnóstico , Eletrodiagnóstico/instrumentação , Eletrorretinografia/instrumentação , Eletrorretinografia/métodos , Humanos , Reprodutibilidade dos Testes , Dispositivos Eletrônicos Vestíveis
4.
Vestn Oftalmol ; 137(1): 78-82, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33610154

RESUMO

Persistent corneal graft erosion or persistent epithelial corneal defect is a frequent complication of penetrating keratoplasty. Its development can be contributed by the dry eye syndrome, rare blinking, lagophthalmos, symblepharon, viral infection, autoimmune aggression, and the use of epithelial-toxic eye drops. The article presents three clinical observations of patients who developed persistent corneal graft erosion after penetrating keratoplasty. Due to the ineffectiveness of local conservative therapy for more than 3 weeks, anterior stromal corneal micropuncture was performed. After the procedure, there was a gradual epithelial proliferation, complete healing of the corneal surface was observed 10-16 days after the manipulation, the follow-up period was at least 1 year. The mechanism of action of stromal micropuncture is associated with the creation of a porous surface with better adhesion properties, as well as with the activation of the production of extracellular matrix glycoproteins such as fibronectin, type IV collagen and laminin, which are necessary for stable adhesion of the epithelium. The use of stromal micropuncture of the donor flap in the treatment of post-keratoplasty persistent corneal epithelial defect was proposed for the first time.


Assuntos
Doenças da Córnea , Transplante de Córnea , Doenças da Córnea/diagnóstico , Doenças da Córnea/etiologia , Doenças da Córnea/cirurgia , Humanos , Ceratoplastia Penetrante/efeitos adversos , Soluções Oftálmicas , Punções
5.
Vestn Oftalmol ; 137(1): 102-105, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33610157

RESUMO

Floppy eyelid syndrome is rarely diagnosed nowadays. Most patients remain without the correct diagnosis for a long time, which means they do not receive adequate treatment. This syndrome is known to be accompanied by many concomitant clinical manifestations complicating the diagnostic search. It should be included in the diagnostic search algorithm in patients with chronic conjunctivitis, abnormal eyelid position, point keratopathy. This review presents the modern understanding of characteristic clinical features, associated conditions, as well as information about the pathogenesis of this syndrome.


Assuntos
Conjuntivite , Doenças da Córnea , Doenças Palpebrais , Conjuntivite/diagnóstico , Conjuntivite/etiologia , Doenças Palpebrais/diagnóstico , Doenças Palpebrais/etiologia , Pálpebras , Humanos , Síndrome
6.
Zhonghua Yan Ke Za Zhi ; 57(2): 95-99, 2021 Feb 11.
Artigo em Chinês | MEDLINE | ID: mdl-33541050

RESUMO

Limbal stem cell deficiency is an ocular surface disease with the imbalance of corneal epithelial homeostasis caused by decrease of number or weakening of function of limbal stem cells. In 2019 and 2020, the international limbal stem cell deficiency working group developed and released the international consensus on the definition, classification, diagnosis, staging and management of limbal stem cell deficiency, which provided a standard protocol for related research and clinical diagnosis and treatment of limbal stem cell deficiency. In order to help Chinese ophthalmologists to properly understand its core components, there is a need to make in-depth interpretation to the key and difficult contents of the international consensus. (Chin J Ophthalmol, 2021, 57: 95-99).


Assuntos
Doenças da Córnea , Epitélio Anterior , Limbo da Córnea , Consenso , Doenças da Córnea/diagnóstico , Doenças da Córnea/terapia , Humanos , Transplante de Células-Tronco , Células-Tronco
7.
Zhonghua Yan Ke Za Zhi ; 57(2): 143-149, 2021 Feb 11.
Artigo em Chinês | MEDLINE | ID: mdl-33541057

RESUMO

Descemet's membrane detachment (DMD) is a complication of intraocular surgery and is more likely to be seen after cataract surgery. As an intraoperative event, DMD usually features wrinkles and edema on the posterior corneal surface or floating membranoid substance seen in the anterior chamber. Such edema is often seen as surgery-caused corneal edema and membranoid substance as the anterior capsule of the lens. Thus, DMD is easily clinically ignored, even though it is conveniently treated if timely observed. Serious consequences are not uncommon with any delayed diagnosis or treatment. Risk factors include advanced age, previous corneal endothelial lesions and glaucoma, as well as preoperative shallow anterior chamber. Clinical diagnosis is based upon intraoperative judgment, corneal edema diagnosed under a microscope or slit lamp and consequent floating Descemet's membrane. In serious cases, anterior segment OCT and UBM are required. Intracameral injections of air are traditionally adopted in the treatment. In less serious cases, patients see self-healing. (Chin J Ophthalmol, 2021, 57: 143-149).


Assuntos
Extração de Catarata , Doenças da Córnea , Edema da Córnea , Câmara Anterior , Doenças da Córnea/diagnóstico , Doenças da Córnea/cirurgia , Edema da Córnea/diagnóstico , Lâmina Limitante Posterior/diagnóstico por imagem , Lâmina Limitante Posterior/cirurgia , Humanos
8.
Indian J Ophthalmol ; 69(3): 706-708, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33595505

RESUMO

Purpose: The aim of this study was to analyze the impact of COVID-19 lockdown on keratoplasty and Eye Banking in India. Methods: An e-mail survey was conducted among cornea surgeons and eye bankers of India. Participants were asked to report their practice patterns for the management of corneal perforation during lockdown, different preservative media used during and before lockdown, and waiting time and waiting time before COVID-19 lockdown. Results: Eight of 20 eye banks did not collect corneal tissue during April-June 2020; in contrast, 9 eye banks used to collect around 100 corneas per month during pre-COVID-19 time. Two-third of the surgeons (66.1%, n = 41/62) did not perform any corneal tissue transplant between April and June 2020. Cyanoacrylate tissue adhesive application was the most commonly, performed procedure (79%, n = 49/62) for tectonic purpose during this period. Glycerol was the most preferred alternative preservation method considered by both the groups. More than half of the surgeons (64.5%, n = 40/62) had an average waiting time of <1 week for scheduling patients for keratoplasty in pre-COVID-19 period. Conclusion: There is was a significant drop in both corneal tissue retrieval and utilization during during COVID-19 lockdown. There was a felt need for an alternate long term storage media.


Assuntos
/epidemiologia , Controle de Doenças Transmissíveis/métodos , Doenças da Córnea/cirurgia , Transplante de Córnea/métodos , Bancos de Olhos/estatística & dados numéricos , Quarentena , Doadores de Tecidos/estatística & dados numéricos , Comorbidade , Doenças da Córnea/epidemiologia , Feminino , Humanos , Índia/epidemiologia , Masculino , Pandemias , Cirurgiões/estatística & dados numéricos , Inquéritos e Questionários
9.
Curr Opin Ophthalmol ; 32(2): 134-140, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33492867

RESUMO

PURPOSE OF REVIEW: Glaucoma patients commonly suffer from ocular surface disease (OSD). As treatment strategies, medications and devices for the treatment of OSD as well as glaucoma surgical approaches evolve rapidly, it is important to consider their application to these patients. RECENT FINDINGS: OSD in glaucoma patients may lead to reduced reliability of diagnostic tests, decreased medication compliance, poor surgical outcomes, and overall decreased quality of life. Chronic use of topical glaucoma medications has been linked to the development of limbal stem cell deficiency, and the role of preservatives in OSD continues to be demonstrated. Preservative free glaucoma medications as well as new anti-inflammatory agents for the treatment of OSD are now available. Omega-3 fatty acid supplementation and punctal plugs have been shown to benefit glaucoma patients with OSD. Drop burden may be reduced through the use of the new sustained-release delivery systems, selective laser trabeculoplasty, and minimally invasive glaucoma surgery. SUMMARY: There are multiple emerging strategies for managing OSD that may be applied to patients with glaucoma. With continued research and clinical experiences, we hope to better understand the multifaceted relationship between glaucoma and OSD and develop evidence-based algorithms for the management of these complex patients.


Assuntos
Doenças da Túnica Conjuntiva/terapia , Doenças da Córnea/terapia , Síndromes do Olho Seco/terapia , Doenças Palpebrais/terapia , Glaucoma/complicações , Doenças do Aparelho Lacrimal/terapia , Anti-Inflamatórios/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Glaucoma/tratamento farmacológico , Humanos , Pressão Intraocular/fisiologia , Conservantes Farmacêuticos/uso terapêutico , Qualidade de Vida
11.
BMC Neurol ; 21(1): 18, 2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33435910

RESUMO

BACKGROUND: Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction. METHODS: This study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period. DISCUSSION: This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea. TRIAL REGISTRATION: The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.


Assuntos
Infarto Cerebral/complicações , Infarto Cerebral/patologia , Doenças da Córnea/etiologia , Sistema de Registros , Adulto , Feminino , Humanos , Masculino , Bulbo/patologia , Pessoa de Meia-Idade
12.
Yakugaku Zasshi ; 141(1): 55-60, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-33390448

RESUMO

The eye is a complex organ with highly specialized constituent tissues derived from different primordial cell lineages. The retina develops from neuroectoderm via the optic vesicle, the corneal epithelium is descended from surface ectoderm, while the iris and corneal stroma have a neural crest origin. Recent work with pluripotent stem cells (PSCs) in culture has revealed a previously under-appreciated level of intrinsic cellular self-organization, with a focus on the retina and retinal cells. We recently demonstrated the generation from human induced pluripotent stem cells (iPSCs) of a self-formed ectodermal autonomous multi-zone (SEAM) of ocular cells. The concentric SEAM mimics whole-eye development because cell location within different zones is indicative of ocular cell lineage, spanning the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium. Therefore, SEAM represents a promising resource for new research of ocular morphogenesis and development. Moreover, we successfully isolated corneal epithelial progenitor cells and fabricated corneal epithelial tissue from PSCs. This approach has translational potential for treating severe corneal epithelial disease by transplantation of PSC-derived corneal epithelial tissue. To evaluate the efficacy and safety of the corneal epithelial tissue, we have started a first-in-human clinical study for patients with corneal epithelial stem cell deficiency, which began last year.


Assuntos
Diferenciação Celular/fisiologia , Epitélio Anterior , Células-Tronco Pluripotentes Induzidas/citologia , Células-Tronco Pluripotentes Induzidas/fisiologia , Medicina Regenerativa/métodos , Linhagem da Célula , Células Cultivadas , Doenças da Córnea/terapia , Epitélio Anterior/citologia , Epitélio Anterior/transplante , Humanos , Organoides , Epitélio Pigmentado da Retina/citologia
13.
Nat Commun ; 12(1): 420, 2021 01 18.
Artigo em Inglês | MEDLINE | ID: mdl-33462242

RESUMO

Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin accessibility landscapes, we delineate core transcription regulatory circuitries (CRCs) of limbal stem/progenitor cells (LSCs) and find that RUNX1 and SMAD3 are required for maintenance of corneal epithelial identity and homeostasis. RUNX1 or SMAD3 depletion inhibits PAX6 and induces LSCs to differentiate into epidermal-like epithelial cells. RUNX1, PAX6, and SMAD3 (RPS) interact with each other and synergistically establish a CRC to govern the lineage-specific cis-regulatory atlas. Moreover, RUNX1 shapes LSC chromatin architecture via modulating H3K27ac deposition. Disturbance of RPS cooperation results in cell identity switching and dysfunction of the corneal epithelium, which is strongly linked to various human corneal diseases. Our work highlights CRC TF cooperativity for establishment of stem cell identity and lineage commitment, and provides comprehensive regulatory principles for human stratified epithelial homeostasis and pathogenesis.


Assuntos
Células-Tronco Adultas/metabolismo , Plasticidade Celular/genética , Doenças da Córnea/patologia , Epitélio Anterior/fisiologia , Redes Reguladoras de Genes/fisiologia , Adolescente , Adulto , Idoso , Linhagem da Célula/genética , Células Cultivadas , Criança , Cromatina/metabolismo , Sequenciamento de Cromatina por Imunoprecipitação , Subunidade alfa 2 de Fator de Ligação ao Core/genética , Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo , Doenças da Córnea/genética , Epitélio Anterior/citologia , Feminino , Regulação da Expressão Gênica , Técnicas de Silenciamento de Genes , Humanos , Limbo da Córnea/citologia , Masculino , Pessoa de Meia-Idade , Fator de Transcrição PAX6/metabolismo , Cultura Primária de Células , RNA-Seq , Proteína Smad3/genética , Proteína Smad3/metabolismo
14.
Arq Bras Oftalmol ; 84(1): 87-90, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33470348

RESUMO

This is a rare case report of acute, paracentral corneal melting and perforation occurring 1 week after an uneventful cataract surgery, with discussions on possible pathogenetic mechanisms. Relevant literature was also reviewed. Herein, a case of an 86-year-old woman with acute, paracentral, and sterile corneal melting and perforation in her left eye at 1 week after an uncomplicated cataract extraction is described. This occurs at the base of ocular surface disorders due to previous radiation of her lower eyelid and cheeks for the treatment of cancer and previously undiagnosed rheumatoid arthritis. She underwent surgical treatment using Gundersen's conjunctival flap for the existing perforation due to low visual expectancies and reluctance to undergo corneal keratoplasty due to the risk of corneal graft rejection. The risk of coming across an acute corneal melting after an uncomplicated cataract surgery in the eyes with ocular surface disorders should always be considered.


Assuntos
Artrite Reumatoide , Extração de Catarata , Catarata , Doenças da Córnea , Radiação , Idoso de 80 Anos ou mais , Artrite Reumatoide/complicações , Doenças da Córnea/etiologia , Doenças da Córnea/cirurgia , Feminino , Humanos
16.
Zhonghua Yan Ke Za Zhi ; 56(12): 956-960, 2020 Dec 11.
Artigo em Chinês | MEDLINE | ID: mdl-33342123

RESUMO

Limbal Stem Cell Deficiency (LSCD) is an ocular surface disease caused by the decrease of the quantity and dysfunction of limbal stem cell, which is characterized by conjunctivalization and other signs of epithelial dysfunction. For sever LSCD, surgery is the main treatment way. Recently, plenty of researches published the outcomes of different operation methods. This article summarized five major operations, including conjunctival limbal autograft (CLAU), simple limbal epithelial transplantation (SLET), limbal allograft, cultivated limbal stem cell transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET). (Chin J Ophthalmol, 2020, 56:956-960).


Assuntos
Doenças da Córnea , Transplante de Córnea , Epitélio Anterior , Limbo da Córnea , Transplante de Células , Doenças da Córnea/cirurgia , Humanos , Transplante de Células-Tronco , Transplante Autólogo
18.
Vestn Oftalmol ; 136(5. Vyp. 2): 177-183, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33063961

RESUMO

PURPOSE: To evaluate the effectiveness and safety of adjuvant anti-VEGF therapy in the surgical treatment of pterygium, and to determine the indications for its use. MATERIAL AND METHODS: The study included 67 patients (69 eyes) with grade II-IV pterygium. Patients age was 58.8±12.6 years on average. Best corrected visual acuity (BCVA) varied between 0.01 and 1.0 (0.77±0.24). The patients were divided into 3 groups. The first group included 19 patients (19 eyes) with grade II-III pterygium who underwent «bare sclera¼ surgery and used aflibercept as adjuvant therapy. The second group included 21 patients (21 eyes) with grade II-IV pterygium who underwent auto conjunctival grafting surgery with no adjuvant therapy. The third group included 27 patients (29 eyes) with grade II-IV pterygium who had it removed in combination with single-time peripheral lamellar keratoplasty (PLK) and underwent adjuvant aflibercept therapy. RESULTS: Among patients who underwent pterygium excision with adjuvant antiangiogenic therapy there were 5 cases (26%) of relapse during the observation period (23.38±8.96 months), among patients after pterygium excision with auto conjunctival plastic surgery - also 5 cases (24%) of relapse, and among patients who underwent LKP combined with anti-VEGF therapy there was only 1 case (3%) of relapse. Astigmatism has decreased by 0.24±0.5 (p=0.052) in the first group, by 1.21±1.0 (p<0.05) in the second group, and by 1.64±1.54 (p<0.05) in the third group compared with pre-surgical values, thus increasing average BCVA in all 3 patient groups by 0.1±0.13, 0.07±0.11 and 0.15±0.15, respectively. CONCLUSION: The use of anti-VEGF agents as adjuvant therapy in the surgical treatment of pterygium is a safe method of reducing postoperative inflammation, fibrovascular proliferation and, subsequently, the amount of relapses.


Assuntos
Astigmatismo , Doenças da Córnea , Transplante de Córnea , Pterígio , Túnica Conjuntiva , Humanos , Pterígio/diagnóstico , Pterígio/tratamento farmacológico , Pterígio/cirurgia
19.
Vestn Oftalmol ; 136(5. Vyp. 2): 214-218, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33063967

RESUMO

As it is known, the main problem of surgical treatment of pterygium is associated with high risk of recurrence. Quite a number of surgical techniques now exist, all aimed at pterygium removal and only differing in the method of conjunctival closure following the excision. Due to relatively low recurrence rates, conjunctival or conjunctival-limbal autografts are currently the 'gold standard' of pterygium surgery. The frequency of recurrence is also insignificant in peripheral anterior lamellar keratoplasty, which is rarely performed due to its complexity and the need for donor cornea. However, it is considered to be the method of choice in cases of repeated recurrence as well as in patients with high pterygium activity. This article describes a clinical case of a massive recurrent pterygium (grade IV, activity level 3). The patient has had three previous surgeries (including conjunctival autotransplantation) that yielded no success. By performing large-diameter peripheral anterior lamellar keratoplasty in combination with adjuvant therapy (intraoperative mitomycin C and subconjunctival postoperative aflibercept injections), structural integrity of the cornea was finally restored without further recurrences and visual acuity was increased.


Assuntos
Doenças da Córnea , Transplante de Córnea , Pterígio , Túnica Conjuntiva/cirurgia , Humanos , Mitomicina , Pterígio/diagnóstico , Pterígio/cirurgia
20.
Vestn Oftalmol ; 136(5. Vyp. 2): 277-282, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33063977

RESUMO

The article reviews modern methods of treatment of persistent corneal epithelial defects and considers the factors involved in the development of this pathology, including the limbal stem cell deficiency, which is likely to play the main role. The most promising treatment methods are described, particularly the use of blood derivatives and cell therapy.


Assuntos
Doenças da Córnea , Doenças da Esclera , Terapia Baseada em Transplante de Células e Tecidos , Doenças da Córnea/diagnóstico , Doenças da Córnea/terapia , Humanos , Células-Tronco
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