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1.
J Am Vet Med Assoc ; 258(5): 502-509, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33620242

RESUMO

OBJECTIVE: To report history, physical examination findings, clinicopathologic abnormalities, treatments, and outcomes of dogs with confirmed α-amanitin toxicosis resulting from ingestion of α-amanitin-containing mushrooms, and to report whether any differences were significant between survivors and nonsurvivors. ANIMALS: 59 dogs. PROCEDURES: Medical records of all dogs with confirmed α-amanitin toxicosis presented to a northern California emergency and specialty veterinary hospital between January 2006 and July 2019 were reviewed for signalment; body weight; history; physical examination findings including rectal temperature at presentation; results of serum biochemical analyses, coagulation tests, and a test for the detection of α-amanitin in urine; treatments; and outcomes. Differences for each were compared between survivors and nonsurvivors. RESULTS: Among the 59 dogs, 36 were < 1 year of age; 56 had variable clinical signs that included vomiting, diarrhea, anorexia, and weakness or lethargy; and 22 had rectal temperatures > 39.2°C (102.5°F) at presentation. Cases were seen throughout the calendar year. At presentation, alanine aminotransferase activity was mildly to markedly increased in 97% of dogs, hypoglycemia was noted in 78%, and coagulation times were prolonged in 91%. Most dogs that rapidly decompensated died; however, 13 dogs survived to hospital discharge and completely recovered. CONCLUSIONS AND CLINICAL RELEVANCE: Ability to recognize dogs with α-amanitin toxicosis on the basis of clinical signs, physical examination findings, and clinicopathologic test results is essential because mushroom ingestion is rarely observed and immediate treatment is necessary. Dogs that have marked hypoglycemia or coagulopathy may have a poor prognosis.


Assuntos
Agaricales , Doenças do Cão , Alfa-Amanitina , Animais , Doenças do Cão/induzido quimicamente , Doenças do Cão/diagnóstico , Doenças do Cão/terapia , Cães , Exame Físico , Estudos Retrospectivos , Vômito/veterinária
2.
Schweiz Arch Tierheilkd ; 163(1): 67-72, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33528368

RESUMO

INTRODUCTION: In this pilot study, we wished to determine if C-reactive protein (CRP) levels could be a useful severity or treatment biomarker for canine atopic dermatitis (AD). Nine atopic dogs received allergen immunotherapy for 1 year. Blood was collected before and at four re-evaluation visits. At each time point, the skin lesions were graded with the Canine Atopic Dermatitis Extent and Severity Index (CADESI) 4, and the plasma CRP levels were measured by Enzyme-linked Immunosorbent Assay (ELISA). We found a significant yet minimal correlation between the CRP levels and the CADESI4 scores. The CRP levels were not significantly different between dogs with AD of increasing severity. Finally, there was no correlation between the percentage change in CADESI4 and CRP values during immunotherapy. In conclusion, the lack of significant difference in CRP levels between dogs of increasing AD severity and lack of correlation between percentage changes in skin lesion and CRP values suggest that this protein would not be a clinically-useful biomarker in atopic dogs.


Assuntos
Biomarcadores/sangue , Proteína C-Reativa/análise , Dermatite Atópica/veterinária , Dessensibilização Imunológica/veterinária , Doenças do Cão/terapia , Animais , Dermatite Atópica/sangue , Dermatite Atópica/patologia , Dermatite Atópica/terapia , Doenças do Cão/sangue , Doenças do Cão/diagnóstico , Cães , Projetos Piloto , Plasma/química
3.
Vet Clin North Am Small Anim Pract ; 51(1): 111-122, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33131913

RESUMO

Canine protein-losing enteropathies occur commonly in small animal practice, and their management is often challenging with a long-term survival rate of only about 50%. Recent studies have investigated prognostic factors that may determine outcome in individual cases. In particular, systemic complications such as hypercoagulability, vitamin D3 deficiency, and tryptophan deficiency may play an important role and should be investigated in severely affected cases in order to maximize outcome.


Assuntos
Doenças do Cão/diagnóstico , Enteropatias Perdedoras de Proteínas/veterinária , Animais , Doenças do Cão/terapia , Cães , Enteropatias Perdedoras de Proteínas/complicações , Enteropatias Perdedoras de Proteínas/diagnóstico
4.
Vet Clin North Am Small Anim Pract ; 51(1): 17-32, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33131915

RESUMO

Aerodigestive disorders (AeroDs) in people encompass a wide range of clinical syndromes, reflecting the complex relationship between the respiratory and digestive tracts. In veterinary medicine, aspiration is used interchangeably with aspiration pneumonia. Although aspiration pneumonia is a common disorder in dogs, it does not reflect the breadth of AeroDs. Unfortunately, AeroDs rarely are investigated in veterinary medicine because of lack of clinical recognition, limitations in available diagnostics, and the fact that AeroDs may be caused by occult digestive disease. Recognizing patients with AerodD represents an area of significant clinical importance that may provide additional areas of clinical intervention.


Assuntos
Doenças do Cão/diagnóstico , Pneumonia Aspirativa/veterinária , Animais , Doenças do Cão/terapia , Cães , Pneumonia Aspirativa/diagnóstico
5.
Vet Clin North Am Small Anim Pract ; 51(1): 79-92, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33131918

RESUMO

Acute hemorrhagic diarrhea syndrome is defined as sudden onset of severe bloody diarrhea frequently associated with vomiting, which results in severe, sometimes life-threatening dehydration. Although there is strong evidence that clostridial overgrowth and toxin release is responsible for the pathogenesis of the disease, the diagnosis is still based on exclusion of other causes for acute hemorrhagic diarrhea. With early and appropriate treatment, mainly based on fluid therapy, the prognosis is good and complications such as sepsis or severe hypoalbuminemia rarely occur.


Assuntos
Diarreia/veterinária , Doenças do Cão/diagnóstico , Hemorragia Gastrointestinal/veterinária , Animais , Diarreia/diagnóstico , Doenças do Cão/terapia , Cães , Hemorragia Gastrointestinal/diagnóstico , Síndrome
6.
Vet Clin North Am Small Anim Pract ; 51(1): 219-233, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33131919

RESUMO

In people, fecal microbiota transplantation is recognized as the best treatment modality for recurrent Clostridioides difficile infection in people, and its value is currently investigated in the treatment of other diseases associated with an abnormal gut microbiome. In dogs, intestinal dysbiosis has been documented in many acute and chronic digestive diseases as well as in diseases of other organ systems. There are only few published studies evaluating the benefits of fecal microbiota transplantation (FMT) in canine gastrointestinal disorders. They provide evidence that FMT may be beneficial in the treatment of acute intestinal diseases and hope that the technique might also be useful for the management of chronic enteropathies.


Assuntos
Infecções por Clostridium/veterinária , Doenças do Cão/terapia , Disbiose/veterinária , Transplante de Microbiota Fecal/veterinária , Animais , Infecções por Clostridium/terapia , Cães , Disbiose/terapia , Microbioma Gastrointestinal
7.
Vet Clin North Am Small Anim Pract ; 51(1): 1-15, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33187619

RESUMO

Esophagitis in cats and dogs is a consequence of increased exposure of the esophageal mucosa to gastroduodenal reflux. Causes can include anesthesia-related reflux, frequent vomiting, or lodged foreign bodies. An exception is eosinophilic esophagitis, an emerging primary inflammatory disease of the esophagus with a presumed allergic etiology. Reflux esophagitis owing to lower esophageal sphincter incompetence is often suspected; a tentative diagnosis can be made by endoscopic assessment, wireless esophageal pH-monitoring, or histologic examination. Because it can be difficult to distinguish diet-responsive upper gastrointestinal disease from esophagitis, response to treatment with gastric acid suppressants is needed to confirm the tentative diagnosis.


Assuntos
Doenças do Gato/diagnóstico , Doenças do Cão/diagnóstico , Esofagite Péptica/veterinária , Animais , Doenças do Gato/patologia , Doenças do Gato/terapia , Gatos , Doenças do Cão/patologia , Doenças do Cão/terapia , Cães , Esofagite Péptica/diagnóstico
8.
Vet Clin North Am Small Anim Pract ; 51(1): 137-153, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33187620

RESUMO

In this article, we review different tests that have been researched in dogs with chronic enteropathy. The usefulness of these tests either to assess etiology, to differentiate between treatment response, or to monitor treatment response is discussed. The tests are divided in those that are commercially available and those that hold promises for further development.


Assuntos
Doenças do Cão/diagnóstico , Doenças Inflamatórias Intestinais/veterinária , Animais , Biomarcadores/sangue , Doença Crônica/veterinária , Testes Diagnósticos de Rotina/veterinária , Doenças do Cão/sangue , Doenças do Cão/terapia , Cães , Doenças Inflamatórias Intestinais/diagnóstico
9.
Vet Clin North Am Small Anim Pract ; 51(1): 43-59, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33187622

RESUMO

Gastric motility disorders present both diagnostic and therapeutic challenges and likely are under-recognized in small animal practice. This review includes a comparative overview of etiopathogenesis and clinical presentation of gastric motility disorders, suggests a practical approach to the diagnosis of these conditions, and provides an update on methods to evaluate gastric motor function. Furthermore, management of gastric dysmotility is discussed, including a review of the documented effect of gastric prokinetics.


Assuntos
Doenças do Gato/diagnóstico , Doenças do Cão/diagnóstico , Íleus/veterinária , Animais , Doenças do Gato/terapia , Gatos , Doenças do Cão/terapia , Cães , Esvaziamento Gástrico , Íleus/diagnóstico , Complicações Pós-Operatórias/veterinária
10.
Vet Clin North Am Small Anim Pract ; 51(1): 61-78, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33187623

RESUMO

In addition to presenting with respiratory signs, many dogs with brachycephalic airway obstructive syndrome show digestive tract signs related to the same conformational abnormalities. A detailed diagnostic investigation is usually required, including clinicopathologic analyses, thoracic radiographs, fluoroscopic studies, abdominal ultrasound examinations and both upper airway and gastrointestinal tract endoscopy. In most cases, medical therapies are successful in managing clinical signs, but surgery can occasionally be required to resolve hiatal hernia or pyloric stenosis. In determining prognosis, the features of each individual case should be considered, with the overall prognosis depending on the severity and extent of all the identified lesions.


Assuntos
Obstrução das Vias Respiratórias/veterinária , Doenças do Cão/diagnóstico , Gastrite/veterinária , Obstrução das Vias Respiratórias/diagnóstico , Animais , Craniossinostoses/veterinária , Doenças do Cão/genética , Doenças do Cão/terapia , Cães , Gastrite/diagnóstico , Linhagem
11.
J Small Anim Pract ; 62(4): 265-271, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33346390

RESUMO

OBJECTIVES: To prospectively describe the impact of gas flow rate and temperature on dog's tolerance of high-flow nasal oxygen therapy during recovery from anaesthesia, hypothesizing that higher flow rates and temperatures will decrease tolerance. MATERIALS AND METHODS: Twelve non-dyspnoeic client-owned dogs recovering from general anaesthesia were included in this study. After extubation, a nasal cannula was positioned and high-flow nasal oxygen therapy was initiated. Two flow rates (two or four time the theoretical minute ventilation: HF2 and HF4), each of them combined with two temperatures (31 and 37°C: T31 and T37), were randomly applied (four conditions per dog). For each condition, cardiovascular and respiratory parameters (heart rate, respiratory rate, systolic arterial blood pressure and pulse oximeter oxygen saturation), sedation score and tolerance score were recorded at initiation (T0 ) and after 10 minutes of accommodation (T10 ). RESULTS: Sedation scores were not significantly different between the four conditions. Cardiovascular and respiratory parameters were not significantly different between any condition at both T0 and T10 . Tolerance scores were good and not significantly different between any flow rate or temperature (HF2-T31: 4 (2-4), HF4-T31: 4 (2-4), HF2-T37: 4 (2-4), HF4-T37: 4 (1-4)). CLINICAL SIGNIFICANCE: The gas flow rates and temperatures studied have no impact on tolerance during the recovery period of non-dyspnoeic dogs, and high-flow nasal cannula is well tolerated. Further studies are required to confirm these results in dyspnoeic dogs.


Assuntos
Doenças do Cão , Oxigenoterapia , Animais , Cânula , Doenças do Cão/terapia , Cães , Dispneia/veterinária , Oxigênio , Oxigenoterapia/veterinária , Temperatura
12.
Viruses ; 12(12)2020 12 10.
Artigo em Inglês | MEDLINE | ID: mdl-33321892

RESUMO

Previous work has indicated that canine parvovirus (CPV) prevalence in the Central Texas region may follow yearly, periodic patterns. The peak in CPV infection rates occurs during the summer months of May and June, marking a distinct "CPV season". We hypothesized that human activity contributes to these seasonal changes in CPV infections. The COVID-19 pandemic resulted in drastic changes in human behavior which happened to synchronize with the CPV season in Central Texas, providing a unique opportunity with which to assess whether these society-level behavioral changes result in appreciable changes in CPV patient populations in the largest CPV treatment facility in Texas. In this work, we examine the population of CPV-infected patients at a large, dedicated CPV treatment clinic in Texas (having treated more than 5000 CPV-positive dogs in the last decade) and demonstrate that societal-behavioral changes due to COVID-19 were associated with a drastic reduction in CPV infections. This reduction occurred precisely when CPV season would typically begin, during the period immediately following state-wide "reopening" of business and facilities, resulting in a change in the typical CPV season when compared with previous years. These results provide evidence that changes in human activity may, in some way, contribute to changes in rates of CPV infection in the Central Texas region.


Assuntos
/epidemiologia , Doenças do Cão/epidemiologia , Infecções por Parvoviridae/veterinária , Animais , Controle de Doenças Transmissíveis/legislação & jurisprudência , Doenças do Cão/terapia , Cães , Hospitais Veterinários , Humanos , Unidades de Terapia Intensiva , Infecções por Parvoviridae/epidemiologia , Infecções por Parvoviridae/terapia , Parvovirus Canino/patogenicidade , Prevalência , Política Pública , Texas/epidemiologia
13.
Korean J Parasitol ; 58(5): 565-569, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33202509

RESUMO

This report describes the first clinical case of a transfusion-associated Mycoplasma haemocanis infection in a dog in Korea. A 6-year-old male Maltese underwent a red blood cell transfusion for idiopathic immune-mediated hemolytic anemia. Eighteen days after the blood transfusion, the recipient's packed cell volume decreased and basophilic organisms were found on erythrocytes. A polymerase chain reaction and sequential analysis showed that both the donor dog and recipient dog had M. haemocanis. Six weeks after doxycycline administration, no organisms were detected and the recipient's anemia had improved.


Assuntos
Anemia Hemolítica Autoimune/terapia , Anemia Hemolítica Autoimune/veterinária , Transfusão de Sangue/veterinária , Doenças do Cão/terapia , Doenças do Cão/transmissão , Doxiciclina/administração & dosagem , Infecções por Mycoplasma/transmissão , Infecções por Mycoplasma/veterinária , Mycoplasma , Reação Transfusional/microbiologia , Reação Transfusional/veterinária , Animais , Doenças do Cão/etiologia , Doenças do Cão/microbiologia , Cães , Masculino , Infecções por Mycoplasma/tratamento farmacológico , Infecções por Mycoplasma/microbiologia , República da Coreia , Resultado do Tratamento
14.
J S Afr Vet Assoc ; 91(0): e1-e9, 2020 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-32787422

RESUMO

The haemostatic status of dogs with canine parvovirus (CPV) enteritis, within 24 h of admission after initial fluid administration, has been described previously, but the haemostatic status at admission and after standard fluid resuscitation, as well as after initial fluid redistribution, has not been investigated previously. The objective of this study was to characterise the haemostatic status at admission and describe the effect of crystalloid fluid resuscitation on haemostatic variables in dogs with CPV enteritis. Twenty-seven client-owned, hospitalised dogs with confirmed natural CPV infection and 15 healthy age-matched controls were included in a prospective, observational clinical study. The volume of resuscitation fluid, haematocrit (HCT), platelet count, thromboelastography (TEG) variables, antithrombin (AT) activity, fibrinogen- and C-reactive protein (CRP) concentrations were measured in all dogs at admission, after fluid resuscitation and, in 10 dogs, after receiving an additional 3 hours of maintenance-rate crystalloid fluids. For the CPV group at admission, the median TEG reaction time (R) and maximum amplitude (MA) or clot strength, as well as the median HCT, fibrinogen and CRP concentrations, were significantly increased compared to the controls. After fluid resuscitation, median R was significantly shorter, MA significantly increased and HCT and AT activity significantly decreased compared to admission values. The haemostatic variables remained unchanged after 3 h of maintenance-rate crystalloid therapy. The increased clot strength present in dogs with CPV enteritis at admission was exacerbated after fluid resuscitation and persisted for hours after large-volume crystalloid fluid administration.


Assuntos
Doenças do Cão/terapia , Enterite/veterinária , Hidratação/veterinária , Hemostasia , Infecções por Parvoviridae/veterinária , Animais , Soluções Cristaloides/uso terapêutico , Cães , Enterite/terapia , Feminino , Masculino , Infecções por Parvoviridae/terapia , Parvovirus Canino/fisiologia , Estudos Prospectivos
15.
PLoS One ; 15(8): e0235689, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32760092

RESUMO

Intertrigo is a skin fold dermatitis often requiring recurrent treatment with topical antiseptics or antibiotics, which can select antimicrobial resistance. To minimize this risk, we tested the effectiveness of medical-grade Manuka honey at treating intertrigo as compared to a placebo hydrogel. We additionally characterized the culturable microbial flora of intertrigo and recorded any adverse effect with either treatment. During this randomized, placebo-controlled, double-blinded, adaptive group-sequential trial, the owners washed the affected sites on their dog with water, dried and applied a thin film of either the honey or the placebo product once daily for 21 days. Cytological and lesional composite scores, owner-assessed pruritus, and microbial cultures were assessed prior to treatment and on Day-22. The fixed effects of time, treatment, and animal-related variables on the pruritus and on each composite score, accounting for random dog effect, were estimated separately with generalized linear mixed models for repeated count outcomes (α = 0.05). The null hypothesis of equal treatment effects was rejected at the first interim analysis. The placebo (n = 16 dogs) outperformed the medical honey (n = 13 dogs) at improving both the cytological score (Treatment×Time = -0.35±0.17; P = 0.04) and clinical score (Treatment×Time = -0.28±0.13; P = 0.04). A microbial burden score higher than 4 increased the severity of the cytological score (dichotomous score: 0.29±0.11; P = 0.01), which in turn increased the severity of the clinical score and pruritus score. For every unit increase in cytological score, the linear predictor of clinical score increased by 0.042±0.019 (P = 0.03), and the one of pruritus score increased by 0.12±0.05 (P = 0.01). However, medical honey outperformed the placebo at alleviating the dog's owner-assessed pruritus after statistically controlling for masking effects (Time = -0.94±0.24; P = 0.002; and Treatment×Time = 0.80±0.36; P = 0.04). Unilateral tests of the least-square mean estimates revealed that honey only significantly improved the pruritus (Hommel-adjusted P = 0.003), while the placebo only improved the cytological and clinical scores (Hommel-adjusted P = 0.01 and 0.002, respectively). Taken together, these results question the value of Manuka honey at treating nasal intertrigo in dogs.


Assuntos
Apiterapia/métodos , Doenças do Cão/terapia , Mel , Intertrigo/veterinária , Prurido/veterinária , Animais , Doenças do Cão/diagnóstico , Doenças do Cão/etiologia , Cães , Método Duplo-Cego , Feminino , Hidrogéis/administração & dosagem , Intertrigo/complicações , Intertrigo/tratamento farmacológico , Masculino , Nariz , Placebos/administração & dosagem , Prurido/diagnóstico , Prurido/tratamento farmacológico , Prurido/etiologia
16.
J Anim Sci ; 98(9)2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32845313

RESUMO

Periodontal disease (PD) is the most common clinical condition occurring in adult dogs. The objective of this study was to evaluate the benefits of daily dental chew administration on oral health outcomes in adult dogs. Twelve adult (mean age = 5.31 ± 1.08 yr; mean BW = 13.12 ± 1.39 kg) female beagle dogs were used in a replicated 4 × 4 Latin square design consisting of 28-d periods. On day 0 of each period, teeth were cleaned by a veterinary dentist blinded to treatments. Teeth then were scored for plaque, calculus, and gingivitis by the same veterinary dentist on day 28 of each period. Breath samples were measured for malodor (volatile sulfur compounds) on days 1, 7, 14, 21, and 27 of each period. All dogs consumed the same commercial dry diet throughout the study. Control dogs were offered the diet only (CT), while treatment groups received the diet plus one of three dental chews. Two novel chews (Bones & Chews Dental Treats [BC]; Chewy, Inc., Dania Beach, FL and Dr. Lyon's Grain-Free Dental Treats [DL]; Dr. Lyon's, LLC, Dania Beach, FL) and a leading brand chew (Greenies Dental Treats [GR]; Mars Petcare US, Franklin, TN) were tested. Each day, one chew was provided 4 h after mealtime. All tooth scoring data were analyzed using the Mixed Models procedure of SAS (version 9.4; SAS Institute, Cary, NC). Halimeter data were analyzed using repeated measures using the Mixed Models procedure of SAS and testing for differences due to treatment, time, and treatment * time interaction. Data are reported as LS means ± SEM with statistical significance set at P < 0.05. DL performed at the same level as the leading brand, GR, as both resulted in lower (P < 0.05) plaque coverage and thickness scores, calculus coverage scores, and day 27 volatile sulfur concentrations compared with CT. Additionally, DL reduced (P < 0.05) volatile sulfur compounds on day 14 when compared with CT. BC reduced (P < 0.05) calculus coverage and day 27 volatile sulfur concentrations compared with CT. Our results suggest that the dental chews tested in this study may help slow the development and/or progression of PD in dogs.


Assuntos
Doenças do Cão , Halitose , Animais , Doenças do Cão/terapia , Cães , Feminino , Gengivite/veterinária , Halitose/veterinária , Mastigação , Avaliação de Resultados em Cuidados de Saúde , Compostos de Enxofre
17.
Vet Rec ; 187(4): e30, 2020 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-32532841

RESUMO

BACKGROUND: The primary purpose of this survey was to determine how veterinary ophthalmologists manage cases of irreversible blindness and to report the most common causes of blindness. METHODS: Respondents completed a questionnaire sent by email with the cooperation of the American College of Veterinary Ophthalmologists, the European College of Veterinary Ophthalmologists and the Latin American College of Veterinary Ophthalmologists. The questionnaire was developed containing 12 questions with both open and closed multiple-choice response options. RESULTS: One hundred and eight veterinary ophthalmologists answered the questionnaire. Of the respondents, 83 per cent had graduated for more than 10 years. Glaucoma (63.56 per cent) was the main cited cause of blindness, followed by progressive retinal atrophy (PRA) (17.80 per cent) and retinal detachment (6.78 per cent). The major concerns of owners refer to the impact of blindness on quality-of-life, (39.31 per cent), followed by depression and anxiety (20 per cent), and environment adaptation (11.72 per cent). General recommendations include avoidance of changes in the domestic environment (18.45 per cent), use of auditory stimulation (14.09 per cent) and avoidance of dangerous areas (12.75 per cent). Almost 31 per cent of professionals do not recommend the use of literature on how to deal with blind pets. CONCLUSIONS: The survey determined glaucoma and PRA as the most common causes of irreversible blindness in pets. Several recommendations that are frequently given to owners of blind pets are presented.


Assuntos
Cegueira/veterinária , Doenças do Gato/terapia , Doenças do Cão/terapia , Oftalmologistas , Medicina Veterinária , Animais , Cegueira/etiologia , Cegueira/terapia , Doenças do Gato/etiologia , Gatos , Doenças do Cão/etiologia , Cães , Feminino , Glaucoma/complicações , Glaucoma/veterinária , Pesquisas sobre Serviços de Saúde , Humanos , Masculino , Propriedade , Animais de Estimação , Degeneração Retiniana/complicações , Degeneração Retiniana/veterinária
18.
J Vet Sci ; 21(3): e42, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32476316

RESUMO

Regenerative medicine using stem cells from various sources are emerging treatment modality in several refractory diseases in veterinary medicine. It is well-known that stem cells can differentiate into specific cell types, self-renew, and regenerate. In addition, the unique immunomodulatory effects of stem cells have made stem cell transplantation a promising option for treating a wide range of disease and injuries. Recently, the medical demands for companion animals have been rapidly increasing, and certain disease conditions require alternative treatment options. In this review, we focused on stem cell application research in companion animals including experimental models, case reports and clinical trials in dogs and cats. The clinical studies and therapeutic protocols were categorized, evaluated and summarized according to the organ systems involved. The results indicate that evidence for the effectiveness of cell-based treatment in specific diseases or organ systems is not yet conclusive. Nonetheless, stem cell therapy may be a realistic treatment option in the near future, therefore, considerable efforts are needed to find optimized cell sources, cell numbers and delivery methods in order to standardize treatment methods and evaluation processes.


Assuntos
Doenças do Gato/terapia , Doenças do Cão/terapia , Transplante de Células-Tronco/veterinária , Animais , Doenças do Gato/cirurgia , Gatos , Doenças do Cão/cirurgia , Cães , Transplante de Células-Tronco/estatística & dados numéricos , Células-Tronco/fisiologia
19.
Top Companion Anim Med ; 39: 100427, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32482289

RESUMO

The aim of this study was to gain a greater understanding of the detection, treatment, and monitoring of hypovolemic shock (HVS) in dogs by general practitioners in the United Kingdom (UK). An online survey was devised and distributed by email to first opinion practices in the UK. All veterinarians working in first opinion practice treating small animals were eligible to complete the survey. Most respondents (n = 164, 93%) were confident with HVS diagnosis. Isotonic crystalloid fluids were the most common fluid type for first-line treatment and administered as a 10-30 mL/kg bolus over 10-30 minutes by 57% respondents. Initial intravenous isotonic crystalloid fluid rates for HVS management ranged from maintenance fluid requirements to 90 mL/kg/hr for an undefined time period. A synthetic colloid was the most popular second-line fluid choice, typically considered after a total administered volume of 60-90 mL/kg of isotonic crystalloid fluids. Only 72 respondents (40.7%) were able to measure blood lactate in-house, which was used routinely by 36 respondents (20.3%) for initial treatment decision making. Respondents treating HVS most frequently were more likely to use lactate for initial decision making (P = .008). This study highlighted variabilities in the initial approach, fluid management strategies and monitoring instituted by UK general practitioners when faced with canine patients in HVS. This suggests that there is a discrepancy in what is determined to be the most optimal diagnostic and treatment plan for canine HVS patients.


Assuntos
Doenças do Cão/diagnóstico , Padrões de Prática Médica , Choque/veterinária , Animais , Doenças do Cão/terapia , Cães , Hidratação/veterinária , Humanos , Ressuscitação/veterinária , Choque/diagnóstico , Choque/terapia , Inquéritos e Questionários , Reino Unido , Médicos Veterinários
20.
Vet Radiol Ultrasound ; 61(4): 471-480, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32323424

RESUMO

Canine oral melanoma (OM) is an aggressive cancer with a high rate of metastasis. Surgery and/or radiotherapy (RT) are effective local treatments, yet many dogs succumb to distant metastasis. Immunotherapy represents an attractive strategy for this potentially immunogenic tumor. The objective of this multi-institutional retrospective study was to examine the clinical outcome of dogs with OM treated with ONCEPT melanoma vaccine. Most dogs also underwent surgery and/or RT (8 Gy × four weekly fractions). Dogs with distant metastasis at diagnosis and those receiving concurrent chemotherapy were excluded. One hundred thirty-one dogs treated with ONCEPT were included: 62 had adequate local tumor control defined as complete tumor excision or irradiation of residual microscopic disease; 15 were treated in the microscopic disease setting following an incomplete excision without adjuvant RT; and 54 had gross disease. Median time to progression, median progression-free survival, and median tumor-specific overall survival were 304, 260, and 510 days, respectively. In multivariable analysis, presence of gross disease correlated negatively with all measures of clinical outcome. Other negative prognostic indicators were primary tumor ≥2 cm, higher clinical stage (stages 2 and 3), presence of lymph node metastasis at diagnosis, and caudal location in the oral cavity. Radiotherapy had a protective effect against tumor progression. To date, this is the largest reported series of dogs with OM treated with ONCEPT. Several previously reported prognostic indicators were confirmed.


Assuntos
Vacinas Anticâncer/uso terapêutico , Terapia Combinada/veterinária , Doenças do Cão/terapia , Melanoma/veterinária , Neoplasias Bucais/veterinária , Radioterapia Adjuvante/veterinária , Animais , Terapia Combinada/métodos , Cães , Feminino , Humanos , Metástase Linfática , Masculino , Melanoma/diagnóstico por imagem , Neoplasias Bucais/terapia , Prognóstico , Estudos Retrospectivos , Resultado do Tratamento
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