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3.
Pediatr Dermatol ; 36(5): 723-724, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31190328

RESUMO

A 6-year-old girl with a history of chronic immunosuppression following small bowel and colon transplantation for tufting enteropathy presented with a diffuse, facial-predominant eruption composed of pink-to-skin-colored papules with central white dystrophic spicules. Histology from a punch biopsy and polymerase chain reaction (PCR) from plucked spicules confirmed a diagnosis of trichodysplasia spinulosa (TS). Additional molecular studies identified several strains of the trichodysplasia spinulosa-associated polyomavirus infecting multiple tissues of the patient, confirming the systemic nature of trichodysplasia spinulosa infections.


Assuntos
Doenças do Cabelo/etiologia , Infecções por Polyomavirus/patologia , Polyomavirus , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Infecções Tumorais por Vírus/patologia , Criança , Feminino , Doenças do Cabelo/patologia , Humanos
4.
Nutr Clin Pract ; 34(4): 490-503, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31144371

RESUMO

Micronutrient deficiencies (MNDs) commonly lead to cutaneous abnormalities involving the skin, hair, and nails, and these cutaneous manifestations often provide clues to the existence of the underlying deficiency. MNDs may be present in at-risk individuals who have impaired absorption or poor dietary intake. The micronutrients that most commonly present with cutaneous findings include the B vitamins riboflavin, niacin, pyridoxine, biotin, and vitamin B12; vitamin C; the fat-soluble vitamins A, E, and K; the minerals zinc, iron, copper, and selenium; and essential fatty acids. This review will highlight the most common clinical hair, skin, and nail presentations associated with MNDs and an approach to their treatment.


Assuntos
Doenças do Cabelo/etiologia , Micronutrientes/deficiência , Doenças da Unha/etiologia , Dermatopatias/etiologia , Feminino , Humanos , Masculino
5.
Indian J Dermatol Venereol Leprol ; 85(4): 374-379, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30971534

RESUMO

Background: Leukotrichia has been considered a predictor of poor outcome in vitiligo. However, studies considering the different clinical aspects of leukotrichia in vitiligo patients are few. Aim: Our aim was to conduct a detailed clinical study to provide insights into the relevance and associations of leukotrichia in non-segmental vitiligo. Methods: In this cross-sectional study, vitiligo patients attending the dermatology outpatient clinic and phototherapy unit at Cairo University Hospital over a period of 6 months (April-September 2016) were included. Family history, clinical details, the Vitiligo Global Issues Consensus Conference classification, the Dermatology Life Quality Index, Vitiligo Area and Severity Index, Vitiligo Extent Score, Vitiligo Disease Activity Score and Vellus Score were determined and these measurements were correlated to leukotrichia. Results: Out of the 101 patients studied, leukotrichia was found in 47 (46.5%) patients, with vellus hair involved in 37 (78.7%), terminal hairs in 30 (63.8%) and both in 20 (42.5%) patients. Vellus hair involvement was significantly higher in generalized bilaterally symmetrical vitiligo than in acrofacial or unclassified vitiligo. The incidence of scalp leukotrichia also was higher in generalized symmetrical vitiligo than in acrofacial vitiligo. The Vellus Score showed significant associations with Vitiligo Area and Severity Index, Vitiligo Extent Score and the Dermatology Life Quality Index. Limitations: This was a short-term study with a small sample size. Prognostic and therapeutic correlations were not studied; prospective longitudinal studies are needed for further evaluation. Conclusion: Leukotrichia was found in almost half of the studied sample and its frequency varied among the different types of vitiligo.


Assuntos
Cor de Cabelo , Doenças do Cabelo/fisiopatologia , Cabelo/fisiopatologia , Vitiligo/fisiopatologia , Adulto , Estudos Transversais , Extremidades , Face , Feminino , Doenças do Cabelo/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Couro Cabeludo , Índice de Gravidade de Doença , Inquéritos e Questionários , Vitiligo/complicações , Adulto Jovem
7.
J Drugs Dermatol ; 18(3): 246-250, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30909328

RESUMO

The purpose of this review is to discuss the disease process and wide variety of treatment options for psuedofolliculitis barbae (PFB), or razor bumps. PFB is caused by hair follicles penetrating the skin and causing an inflammatory response. PFB can occur to anyone who shaves, and is more likely in those with curly hair. PFB can cause significant hyperpigmentation and scarring, more noticeable in darker skin types. PFB can be treated with a variety of topical, systemic, or light/laser therapies. Minimal progress has been made in treating PFB in recent years, partially due to the success of well-established current treatments discussed in this review. The most effective treatments involve a multifaceted approach including behavioral changes in shaving habits as well as the use of topical therapies. J Drugs Dermatol. 2019;18(3):246-250.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Doenças do Cabelo/terapia , Remoção de Cabelo/efeitos adversos , Terapia com Luz de Baixa Intensidade/métodos , Fotoquimioterapia/métodos , Administração Cutânea , Administração Oral , Antibacterianos/uso terapêutico , Face , Hábitos , Doenças do Cabelo/epidemiologia , Doenças do Cabelo/etiologia , Folículo Piloso/patologia , Folículo Piloso/efeitos da radiação , Humanos , Queratinas Específicas do Cabelo/genética , Queratinas Tipo II/genética , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
8.
J Dtsch Dermatol Ges ; 17(6): 589-596, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30873720

RESUMO

The essential trace element zinc (Zn) plays a key role in the development, differentiation and growth of various human tissues. Zinc homeostasis is primarily regulated by two zinc transporter families (solute-linked carrier families, SLC). Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. An autosomal recessive zinc deficiency disorder, acrodermatitis enteropathica is caused by a mutation in the gene coding for the ZIP4 transporter. Due to intestinal malabsorption, affected infants develop clinical signs and symptoms shortly after weaning. Acquired zinc deficiency is a rare but underdiagnosed disorder associated with various etiologies and variable clinical manifestations. Depending on the patient's age, a multitude of causes have to be considered. Given the characteristic periorificial and acral lesions, the clinical diagnosis is usually made by dermatologists. Laboratory confirmation includes measurement of plasma zinc levels and - as a supplementary measure - zinc-dependent enzymes such as alkaline phosphatase. Oral zinc replacement therapy frequently leads to clinical remission within a few days. Depending on the cause, disease management should include cooperation with pediatricians and gastroenterologists in order to guarantee optimal patient care.


Assuntos
Dermatopatias/etiologia , Zinco/fisiologia , Acrodermatite/etiologia , Acrodermatite/patologia , Criança , Pré-Escolar , Diagnóstico Diferencial , Doenças do Cabelo/etiologia , Humanos , Lactente , Síndromes de Malabsorção/complicações , Dermatopatias/patologia , Cicatrização/fisiologia , Zinco/deficiência
9.
Am J Hum Genet ; 104(3): 520-529, 2019 03 07.
Artigo em Inglês | MEDLINE | ID: mdl-30824121

RESUMO

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes responsible for charging tRNA molecules with cognate amino acids. Consistent with the essential function and ubiquitous expression of ARSs, mutations in 32 of the 37 ARS-encoding loci cause severe, early-onset recessive phenotypes. Previous genetic and functional data suggest a loss-of-function mechanism; however, our understanding of the allelic and locus heterogeneity of ARS-related disease is incomplete. Cysteinyl-tRNA synthetase (CARS) encodes the enzyme that charges tRNACys with cysteine in the cytoplasm. To date, CARS variants have not been implicated in any human disease phenotype. Here, we report on four subjects from three families with complex syndromes that include microcephaly, developmental delay, and brittle hair and nails. Each affected person carries bi-allelic CARS variants: one individual is compound heterozygous for c.1138C>T (p.Gln380∗) and c.1022G>A (p.Arg341His), two related individuals are compound heterozygous for c.1076C>T (p.Ser359Leu) and c.1199T>A (p.Leu400Gln), and one individual is homozygous for c.2061dup (p.Ser688Glnfs∗2). Measurement of protein abundance, yeast complementation assays, and assessments of tRNA charging indicate that each CARS variant causes a loss-of-function effect. Compared to subjects with previously reported ARS-related diseases, individuals with bi-allelic CARS variants are unique in presenting with a brittle-hair-and-nail phenotype, which most likely reflects the high cysteine content in human keratins. In sum, our efforts implicate CARS variants in human inherited disease, expand the locus and clinical heterogeneity of ARS-related clinical phenotypes, and further support impaired tRNA charging as the primary mechanism of recessive ARS-related disease.


Assuntos
Aminoacil-tRNA Sintetases/genética , Doença de Charcot-Marie-Tooth/etiologia , Deficiências do Desenvolvimento/etiologia , Doenças do Cabelo/etiologia , Microcefalia/etiologia , Mutação , Doenças da Unha/etiologia , Adulto , Sequência de Aminoácidos , Doença de Charcot-Marie-Tooth/enzimologia , Doença de Charcot-Marie-Tooth/patologia , Deficiências do Desenvolvimento/enzimologia , Deficiências do Desenvolvimento/patologia , Feminino , Genes Recessivos , Predisposição Genética para Doença , Doenças do Cabelo/enzimologia , Doenças do Cabelo/patologia , Humanos , Masculino , Microcefalia/enzimologia , Microcefalia/patologia , Doenças da Unha/enzimologia , Doenças da Unha/patologia , Linhagem , Fenótipo , Prognóstico , Homologia de Sequência , Adulto Jovem
11.
Cutis ; 103(1): 46-50, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30758335

RESUMO

Pityriasis amiantacea (PA) is a hair disorder characterized by matting of multiple hair shafts, typically occurring as an idiopathic condition. A 67-year-old woman with multiple myeloma who developed PA following a bone marrow transplant with melphalan conditioning is described.She noted initial changes in scalp hair regrowth 4 weeks posttransplant. During the next 4 months she developed multiple lesions of PA that rapidly responded to management, including mineral oil under occlusion in the evening followed by daily shampooing with alternating coal tar, salicylic acid, and ketoconazole shampoos. We review medications that have been associated with PA and conditions related to PA, including atopic dermatitis, bacterial infection, fungal infection, psoriasis, and seborrheic dermatitis. Our patient developed PA that was associated with either melphalan conditioning, bone marrow transplant, or both.


Assuntos
Transplante de Medula Óssea/efeitos adversos , Doenças do Cabelo/terapia , Mieloma Múltiplo/terapia , Pitiríase/terapia , Idoso , Feminino , Doenças do Cabelo/etiologia , Humanos , Pitiríase/etiologia
13.
J Am Acad Dermatol ; 80(5): 1179-1196, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-29660422

RESUMO

Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders, including alopecia, hirsutism, hypertrichosis, and pigmentary and textural hair changes. The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy-induced alopecia has been well documented primarily in the oncology literature; however, the effect of other alterations, such as radiation-induced alopecia, hirsutism, and changes in hair color or texture on quality of life have not been described. This article reviews clinically significant therapy-related hair disorders in oncology patients, including the underlying pathophysiological mechanisms, severity grading scales, patient-reported quality of life questionnaires, management strategies, and future translational research opportunities.


Assuntos
Antineoplásicos/efeitos adversos , Crioterapia , Doenças do Cabelo/etiologia , Neoplasias/terapia , Radioterapia/efeitos adversos , Alopecia/etiologia , Alopecia/prevenção & controle , Doenças do Cabelo/psicologia , Doenças do Cabelo/terapia , Humanos , Imunoterapia/efeitos adversos , Terapia de Alvo Molecular/efeitos adversos , Transtornos da Pigmentação/etiologia , Qualidade de Vida , Índice de Gravidade de Doença
14.
J Am Acad Dermatol ; 80(5): 1199-1213, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-29660423

RESUMO

With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, postsurgery alopecia and localized hypertrichosis, and persistent stem cell transplantation and targeted therapy-induced alopecia. The information contained in this continuing medical education series should facilitate a better understanding on hair disorders in cancer survivors so that adequate support and therapies may be provided.


Assuntos
Sobreviventes de Câncer , Doenças do Cabelo/etiologia , Doenças do Cabelo/terapia , Alopecia/etiologia , Alopecia/patologia , Alopecia/terapia , Antineoplásicos/efeitos adversos , Sobreviventes de Câncer/psicologia , Hirsutismo/induzido quimicamente , Hirsutismo/terapia , Humanos , Hipertricose/etiologia , Hipertricose/terapia , Qualidade de Vida , Radioterapia/efeitos adversos
15.
Clin Dermatol ; 37(5): 516-519, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31896406

RESUMO

Greenish staining of human skin may result from a gamut of causes, such as chlorosis, exogenous copper, resolving ecchymosis, drugs, green textile dyes, green tattoos, apocrine and eccrine chromhidrosis, hyper biliverdinemia, chloromas, use of green dyes during tube feeding in patient with multiorgan failure, Pseudomonas infections, and Wells' syndrome in its second stage. Physicians may rarely encounter patients with green skin, hair, nails, or mucosae.


Assuntos
Anemia Hipocrômica/complicações , Doenças da Unha/etiologia , Transtornos da Pigmentação/etiologia , Cor , Cobre/efeitos adversos , Doenças do Cabelo/etiologia , Humanos , Hepatopatias/complicações , Membrana Mucosa , Sarcoma Mieloide/complicações
16.
BMC Womens Health ; 18(1): 172, 2018 10 22.
Artigo em Inglês | MEDLINE | ID: mdl-30348152

RESUMO

BACKGROUND: Pubic hair grooming, including the complete removal of pubic hair, has become an increasingly common practice, particularly among young women. Although widespread, there is limited data regarding the methods, products, reasons, and complications of pubic hair removal, particularly among Saudi women. The objective was to examine pubic hair removal practices and the prevalence of its complications among Saudi women living in Jeddah, Saudi Arabia. METHODS: In this cross-sectional study conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, Saudi women between 16 and 60 years of age who had the ability to read and speak Arabic, were eligible to complete an anonymous and self-administered survey on pubic hair removal practices and its complications. RESULTS: Between December 2015 and September 2016, 400 Saudi women completed the survey. The age was 26.3 ± 6.9, 16-58 (mean ± SD, range) years. About three quarters (77.0%) self-removed their pubic hair, while the remainder made use of professional personnel in medical clinics (15.5%), beauty salons (5.3%), and professional services at home (2.2%). Many women (41.8%) used a combination of hair removal methods, with non-electric razor as the most common single method used (33.5%), followed by laser (8.7%), sugaring (6.0%), waxing (4.5%), trimming (2.0%), electric razor (2.0%), and cream (1.5%). Three-quarters of women (75.5%) reported complications, and although they were mostly minor injuries, treatment had to be sought for 17.9% of complications. Multivariable analyses showed that no variables remained correlated with the occurrence of complications (age of starting hair removal, income, BMI, level of education, mode of removal, advice on removal). CONCLUSIONS: Saudi women initiate pubic hair removal in early adolescence. While most complications are minor, close to one in five women experience complications.


Assuntos
Doenças do Cabelo/etiologia , Remoção de Cabelo/efeitos adversos , Remoção de Cabelo/psicologia , Comportamento Sexual/psicologia , Comportamento Sexual/estatística & dados numéricos , Vagina , Adolescente , Adulto , Estudos Transversais , Feminino , Remoção de Cabelo/estatística & dados numéricos , Humanos , Pessoa de Meia-Idade , Arábia Saudita , Inquéritos e Questionários , Adulto Jovem
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