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1.
J Oleo Sci ; 69(9): 1087-1093, 2020 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-32788522

RESUMO

Previously, we reported that the polar lipid fraction from the golden oyster mushroom, Pleurotus citrinopileatus, suppresses colon injuries which result from apoptosis induced by inflammatory stresses in vivo and in vitro (Yamashita et al., J. Oleo Sci., 69, 751-757 (2020)). Here, we investigated the use of lipid classes in mushroom polar lipid fraction in alleviating colon injury using differentiated Caco-2 cells as an intestinal tract model. The mushroom polar lipid fraction was separated into four fractions using silica thin layer chromatography. Each mushroom polar lipid fraction suppressed lipopolysaccharide (LPS)-induced decreases in the viability of intestinal cells, and the effects of sphingolipid fractions were significantly stronger than those of fraction that did not contain sphingolipids. Addition of sphingolipid fractions suppressed the expression of apoptosis-related proteins (e.g., death receptors and caspases) in the LPS-treated cells. Mushroom polar lipids, especially sphingolipids suppress intestinal apoptosis induced by inflammatory stress, and highly polar sphingolipids may exert stronger suppressive effects.


Assuntos
Apoptose/efeitos dos fármacos , Doenças do Colo/tratamento farmacológico , Doenças do Colo/patologia , Fitoterapia , Pleurotus/química , Esfingolipídeos/isolamento & purificação , Esfingolipídeos/farmacologia , Apoptose/genética , Células CACO-2 , Caspases/genética , Caspases/metabolismo , Fracionamento Químico , Doenças do Colo/induzido quimicamente , Expressão Gênica , Humanos , Técnicas In Vitro , Inflamação , Lipopolissacarídeos , Esfingolipídeos/uso terapêutico
2.
Sci Rep ; 10(1): 8854, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-32483125

RESUMO

Diverticular disease affects ∼5-10% people worldwide, yet the indications for elective colectomy in uncomplicated diverticulitis are unclear. As there is no strong scientific evidence regarding histology in diverticular disease, the primary outcome of the study was to analyze the degree of inflammation of colonic wall in patients that underwent elective colectomy for uncomplicated diverticulitis and to retrospectively assess the correlation between patient clinical history and pathological features of surgical specimens in order to find some predictive factors that may be strictly correlated with histology. An observational retrospective study was conducted. Patients undergoing elective colectomy for uncomplicated diverticulitis between January 2014 and January 2016 in an academic medical center were collected. The majority of patients (46.2%) had previously encountered one episode of acute diverticulitis prior to colectomy, while 21.5% and 10.8% had experienced two and three or more prior episodes respectively. Most patients had recurrent or chronic abdominal pain in the left iliac fossa (66.2%) for diverticular disease and a large proportion also experienced constipation (40.0%). Diverticulitis was identified pathologically as being "mild" in 44.6% patients and "severe" in 55.4% patients. The mean age was significantly lower in patients with severe diverticulitis (56.7 years) than in patients with mild diverticulitis (67.0 years). 71.9% of males had severe diverticulitis compared to 39.4% of females. Males have a 3.9 times higher risk of histological severe diverticulitis than females (OR = 3.932; 1.390-11.122; p = 0.008). Multivariate logistic regression analysis confirmed that age and gender were independent factors associated with histological diagnosis. Single-institution data and retrospective design were main limitations of this study. Age and gender are independent factors associated with severity inflammation index derived at histological analysis and they could be translated to clinical practice to better categorize patients with uncomplicated diverticulitis at the bedside.


Assuntos
Doenças do Colo/cirurgia , Diverticulite/cirurgia , Fatores Etários , Idoso , Colectomia , Doenças do Colo/patologia , Diverticulite/patologia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Estudos Retrospectivos , Índice de Gravidade de Doença , Fatores Sexuais
3.
Sci Rep ; 10(1): 9146, 2020 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-32499543

RESUMO

BACKGROUND: Infectious gastroenteritis is a risk factor for the development of post-infectious Irritable Bowel Syndrome (PI-IBS). Recent clinical studies reported a higher prevalence of the intestinal parasite Blastocystis in IBS patients. Using a rat model, we investigated the possible association between Blastocystis infection, colonic hypersensitivity (CHS), behavioral disturbances and gut microbiota changes. METHODS: Rats were orally infected with Blastocystis subtype 4 (ST4) cysts, isolated from human stool samples. Colonic sensitivity was assessed by colorectal distension and animal behavior with an automatic behavior recognition system (PhenoTyper), the Elevated Plus Maze test and the Forced Swimming tests. Feces were collected at different time points after infection to study microbiota composition by 16 S rRNA amplicon sequencing and for short-chain fatty acid (SFCA) analysis. RESULTS: Blastocystis-infected animals had non-inflammatory CHS with increased serine protease activity. Infection was also associated with anxiety- and depressive-like behaviors. Analysis of fecal microbiota composition showed an increase in bacterial richness associated with altered microbiota composition. These changes included an increase in the relative abundance of Oscillospira and a decrease in Clostridium, which seem to be associated with lower levels of SCFAs in the feces from infected rats. CONCLUSIONS: Our findings suggest that experimental infection of rats with Blastocystis mimics IBS symptoms with the establishment of CHS related to microbiota and metabolic shifts.


Assuntos
Comportamento Animal/fisiologia , Infecções por Blastocystis/patologia , Blastocystis/patogenicidade , Doenças do Colo/complicações , Disbiose/etiologia , Animais , Área Sob a Curva , Infecções por Blastocystis/complicações , Doenças do Colo/patologia , Modelos Animais de Doenças , Ácidos Graxos Voláteis/análise , Fezes/microbiologia , Fezes/parasitologia , Microbiota , Curva ROC , Ratos , Ratos Wistar , Serina Proteases/metabolismo
5.
Cell Mol Life Sci ; 77(17): 3311-3323, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32166393

RESUMO

The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types. Primarily described as involved in several cancer and colonic diseases physiopathological mechanisms, the SLC6A14 gene has been more recently identified as a genetic modifier of cystic fibrosis (CF) disease severity. It was indeed shown to have a pleiotropic effect, modulating meconium ileus occurrence, lung disease severity, and precocity of P. aeruginosa airway infection. The biological mechanisms explaining the impact of SLC6A14 on intestinal and lung phenotypes of CF patients are starting to be elucidated. This review focuses on SLC6A14 in lung and gastrointestinal physiology and physiopathology, especially its involvement in the pathophysiology of CF disease.


Assuntos
Sistemas de Transporte de Aminoácidos/metabolismo , Fibrose Cística/patologia , Trato Gastrointestinal/metabolismo , Pulmão/metabolismo , Sistemas de Transporte de Aminoácidos/genética , Doenças do Colo/genética , Doenças do Colo/metabolismo , Doenças do Colo/patologia , Fibrose Cística/genética , Fibrose Cística/metabolismo , Variação Genética , Humanos , Desequilíbrio de Ligação , Neoplasias/genética , Neoplasias/metabolismo , Neoplasias/patologia , Índice de Gravidade de Doença
7.
J Gynecol Obstet Hum Reprod ; 49(4): 101697, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32018043

RESUMO

INTRODUCTION: Rectosigmoid endometriosis and Dolichocolon can both present with a triad of chronic abdominal pain, constipation and bloating. The relationship between these two pathologies is unknown. The present study aims to determine the frequency of DC in women with rectosigmoid endometriosis and its possible impact on pre- and post-operative symptoms. MATERIAL AND METHODS: We conducted a retrospective cohort study on 113 consecutive patients submitted to magnetic resonance imaging enema and subsequent complete surgical removal for symptomatic rectosigmoid endometriosis between June 2015 to June 2018. Dolichocolon is an anatomic variant characterized by redundancies and lengthening of the colon. We divided our study population according to its presence or absence. The two groups were compared in terms of demographic data, surgical findings and pre- and post-operative clinical variables. Pain symptoms were assessed through numerical rating scale from 0 to 10. Bowel complaints included constipation, bloating and diarrhea. RESULTS: Thirty-five patients (31 %) presented a dolichocolon at magnetic resonance imaging enema. The two groups were comparable in terms of demographic data, pre-operative clinical variables and surgical findings. At 6-month follow-up, there was a significant improvement of symptoms, except for constipation and bloating in dolichocolon group. In particular, we observed with a statistical difference (p < .05) the persistence of constipation and bloating in dolichocolon group compared to non-dolichocolon group. CONCLUSIONS: Dolichocolon was observed in one third patients with rectosigmoid endometriosis and could influence surgical outcomes for rectosigmoid endometriosis in terms of relief of bowel symptoms.


Assuntos
Colo/patologia , Doenças do Colo/patologia , Doenças do Colo/cirurgia , Endometriose/cirurgia , Doenças Retais/cirurgia , Doenças do Colo Sigmoide/cirurgia , Adulto , Doenças do Colo/fisiopatologia , Constipação Intestinal , Diarreia , Feminino , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Dor , Doenças Retais/patologia , Doenças Retais/fisiopatologia , Estudos Retrospectivos , Doenças do Colo Sigmoide/patologia , Doenças do Colo Sigmoide/fisiopatologia , Resultado do Tratamento
8.
J Clin Pathol ; 73(8): 514-518, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31919142

RESUMO

Genomic technologies are increasingly used clinically for both diagnosis and guiding cancer therapy. However, formalin fixation can compromise DNA quality. This study aimed to optimise tissue fixation using normal colon, liver and uterus (n=8 each) by varying neutral buffered formalin (NBF) concentration (1%-5% w/v) and fixation time (24-48 hours). Fixation using 4% NBF improved DNA quality (assessed by qPCR) compared with routine (4% unbuffered formal saline-fixed) specimens (p<0.01). Further improvements were achieved by reducing NBF concentration (p<0.00001), whereas fixation time had no effect (p=0.110). No adverse effects were detected by histopathological or QuPath morphometric analysis. Immunohistochemistry for multicytokeratin and α-smooth muscle actin revealed no changes in staining specificity or intensity in any tissue other than on liver multicytokeratin staining intensity, where the effect of fixation time was more significant (p=0.0004) than NBF concentration (p=0.048). Thus, reducing NBF concentration can maximise DNA quality without compromising tissue morphology or standard histopathological analyses.


Assuntos
DNA/isolamento & purificação , Fixadores/farmacologia , Formaldeído/farmacologia , Inclusão em Parafina/normas , Doenças do Colo/patologia , Feminino , Humanos , Imuno-Histoquímica/normas , Hepatopatias/patologia , Melhoria de Qualidade , Coloração e Rotulagem/normas , Fixação de Tecidos/normas , Doenças Uterinas/patologia
9.
Saudi J Gastroenterol ; 26(1): 39-45, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31997777

RESUMO

Background/Aims: The aim of this study was to investigate the specificity and sensitivity of eosinophil cutoff points defining the colonic tissue eosinophilia (TE) and compare the yield of reporting the highest count versus the mean of five high-power fields (HPFs). Materials and Methods: One hundred and seventy-one cases of colonic TE, including 22 primary eosinophilic colitis (PEC) cases, were compared to one hundred and twenty-one normal controls in the University of Jordan. The highest eosinophil count (EC) and the mean of five HPFs were recorded. The receiver operating characteristic curve (ROC) analysis was used to find the cutoff point with the best sensitivity and specificity. Results: There was no significant advantage of counting five fields over counting the most densely populated HPF. Using 30 eosinophils per HPF achieved 80% sensitivity and 65% specificity. This point is close to the mean in normal controls plus one standard deviation (SD) (29 per HPF). However, there was overlap between normal counts and TE, using 30 as a cutoff point resulted in 35% false-positive rate. There was no reliable cutoff point to differentiate PEC from secondary TE. Conclusion: We recommend reporting the highest EC in colonic biopsies and using 30 as a cutoff point, bearing in mind the overlap with normal and correlating with the clinical team to not treat asymptomatic patients. Clinicopathological correlation is essential to separate PEC from secondary TE.


Assuntos
Doenças do Colo/sangue , Enterite/sangue , Eosinofilia/diagnóstico , Eosinófilos/patologia , Gastrite/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Estudos de Casos e Controles , Doenças do Colo/patologia , Enterite/patologia , Eosinofilia/sangue , Eosinofilia/patologia , Feminino , Gastrite/patologia , Humanos , Jordânia/epidemiologia , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Curva ROC , Estudos Retrospectivos , Sensibilidade e Especificidade , Adulto Jovem
10.
J Minim Invasive Gynecol ; 27(2): 441-451.e2, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31785416

RESUMO

OBJECTIVE: The recurrence rate after colorectal surgery for endometriosis is up to 50% at 5 years. The aim of the current review and meta-analysis was to assess recurrence associated with shaving, disc excision, and segmental resection for endometriosis with colorectal involvement. DATA SOURCES: A systematic review was performed by searching the PubMed, ClinicalTrials.gov, EMBASE, Cochrane Library, and Web of Science databases for publications before February 28, 2019, using the terms "colorectal endometriosis" and "recurrence" in English. The outcome measure was histologically proven recurrence 1 year after the index surgery. METHODS OF STUDY SELECTION: Studies rated as good or fair by a study quality assessment tool were included. Two reviewers independently assessed the quality of the studies; discrepancies were discussed, and if a consensus was not reached, a third reviewer was consulted. TABULATION, INTEGRATION, AND RESULTS: Of 156 relevant published trials, 41 were systematically reviewed and 4 were included in the meta-analysis. The risk of recurrence was higher after rectal shaving than after both segmental resection (odds ratio [OR], 5.53; 95% confidence interval [CI], 2.33-13.12; I2 = 0%; p = .001) and disc excision for histologically proven recurrence (OR, 3.83; 95% CI, 1.33-11.05; I2 = 0%; p = .01). This difference was not significant when comparing disc excision with segmental resection (OR, 2.63; 95% CI, 0.8-8.65; I2 = 0%; p = .11). CONCLUSION: The current analysis shows that the risk of recurrence is lower when segmental resection or disc excision is performed than when rectal shaving is performed. This finding is important when deciding the most appropriate surgical management.


Assuntos
Doenças do Colo/cirurgia , Endometriose/cirurgia , Complicações Pós-Operatórias , Doenças Retais/cirurgia , Ensaios Clínicos como Assunto/estatística & dados numéricos , Doenças do Colo/epidemiologia , Doenças do Colo/patologia , Bases de Dados Factuais , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Procedimentos Cirúrgicos do Sistema Digestório/estatística & dados numéricos , Endometriose/epidemiologia , Endometriose/patologia , Feminino , Humanos , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/patologia , Complicações Pós-Operatórias/cirurgia , Doenças Retais/epidemiologia , Doenças Retais/patologia , Recidiva , Resultado do Tratamento
11.
Vet Radiol Ultrasound ; 61(2): 190-196, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31837190

RESUMO

Colonic torsion is a life-threatening condition that results in colonic ischemia, necrosis, perforation, sepsis, and eventual death. The aim of this multicenter, retrospective case series study was to describe the CT findings in dogs with surgically confirmed colonic torsion. Medical records were searched for dogs with surgically confirmed colonic torsion following abdominal CT. Five dogs met the inclusion criteria. Three had a history of chronic intermittent diarrhea prior to presentation. Two dogs presented with acute vomiting, diarrhea, and abdominal pain and one dog presented with acute vomiting and lethargy. Computed tomographic findings in all dogs with surgically confirmed colonic torsion include: "whirl sign," displacement and distension of the cecum and colon, focal narrowing of the colon, and distension of the mesenteric vasculature in all dogs (5/5); streaky peritoneal fat and peritoneal effusion (4/5), pneumatosis coli (2/5), small intestinal distension (2/5), portal vein thrombosis (1/5), and reduced colonic wall contrast enhancement (1/5). In all dogs (5/5), the torsion site was the descending colon and demonstrated an anticlockwise rotation. At surgery, three of the five dogs had a partial colonic torsion with hyperemia at the site of obstruction and two of the five dogs had a complete torsion with marked necrosis of the colonic wall. Displacement of the colon and cecum, segmental distension and focal narrowing of the colon, the presence of a "whirl sign" and distension of the mesenteric vasculature are CT findings highly suggestive of colonic torsion.


Assuntos
Doenças do Colo/veterinária , Doenças do Cão/diagnóstico por imagem , Volvo Intestinal/veterinária , Tomografia Computadorizada por Raios X/veterinária , Anormalidade Torcional/veterinária , Animais , Colo/diagnóstico por imagem , Colo/patologia , Doenças do Colo/diagnóstico por imagem , Doenças do Colo/patologia , Cães , Feminino , Volvo Intestinal/diagnóstico por imagem , Volvo Intestinal/patologia , Masculino , Estudos Retrospectivos , Anormalidade Torcional/diagnóstico por imagem , Anormalidade Torcional/patologia
12.
Int J Colorectal Dis ; 35(2): 213-222, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31823053

RESUMO

BACKGROUND: Melanosis coli (MC) is a colonoscopic finding in which the colonic mucosa appears darkly pigmented than usual and generally caused by extended anthranoid laxative use. METHODS: We performed a retrospective study at Zhuhai Hospital to investigate the risk of MC for CR neoplasm development. A total of 12,776 patients who underwent colonoscopy from 2013 to 2016 including 250 diagnosed with MC and 500 controls were included in this study. Odds ratios (OR) and 95% confidence intervals (95%CI) for associations of MC with CR neoplasm detection were estimated using univariate and multivariable multinomial logistic analyses for known risk factors. RESULTS: The presence of MC was associated with a significant increase in the CR neoplasm detection rate compared with controls (OR = 1.701, 95% CI = 1.252-2.31; P = 0.001). The effect was also observed in different tumor sites, age group, gender, and lifestyle. Using univariate multinomial analysis, patients with MC were significantly associated with both hyperplastic polyp (OR = 2.069, 95% CI = 1.253-3.415; P = 0.005) and low-grade (LG) adenoma (OR = 1.585, 95% CI = 1.115-2.254; P = 0.010). However, there was no significant difference with adenocarcinoma (OR = 1.701, 95% CI = 0.990-2.924; P = 0.055). Using multivariate multinomial analysis, MC patients remained associated with increased hyperplastic polyp (OR = 1.870, 95% CI = 1.119-3.125; P = 0.017) and LG adenoma (OR = 1.474, 95% CI = 1.027-2.114; P = 0.035), but not adenocarcinoma (OR = 1.620, 95% CI = 0.914-2.871; P = 0.098). A significant increase in CR neoplasm rate was observed with drinker, smoker, and elderly patients but not with gender. CONCLUSION: Patients with MC were more likely to have both hyperplastic polyp and LG adenoma. If confirmed, such findings could suggest the discontinuation of anthranoid laxative use particularly in the elderly.


Assuntos
Pólipos Adenomatosos/epidemiologia , Colo/patologia , Doenças do Colo/epidemiologia , Pólipos do Colo/epidemiologia , Colonoscopia , Neoplasias Colorretais/epidemiologia , Mucosa Intestinal/patologia , Melanose/epidemiologia , Pólipos Adenomatosos/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Colo/química , Doenças do Colo/patologia , Pólipos do Colo/patologia , Neoplasias Colorretais/patologia , Feminino , Humanos , Mucosa Intestinal/química , Masculino , Melaninas/análise , Melanose/patologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prevalência , Prognóstico , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores de Tempo , Adulto Jovem
14.
Dig Dis Sci ; 65(2): 391-398, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31728786

RESUMO

INTRODUCTION: Amyloidosis is an uncommon disease caused by the deposition of amyloid fibrils in tissues. This disease does not usually require surgical intervention, which could be warranted in the presence of complications such as bleeding, obstruction, or perforation. We present a case of primary amyloidosis of the colon in a patient affected by polymyositis who underwent Hartmann's procedure after a spontaneous colonic perforation. After 2 months of well-being, the patient underwent two consecutive surgical procedures for stenosis of the ostomy orifice. AREAS COVERED: A review of the literature has been performed, gathering case reports highlighting the distribution of this disease by age, gender, location, and treatment when available. EXPERT COMMENTARY: Gastrointestinal amyloid disease is a rare condition, and it could be considered among the rare causes of intestinal perforation. Timely surgical management is often necessary.


Assuntos
Amiloidose/patologia , Colectomia , Colite/patologia , Colostomia , Perfuração Intestinal/cirurgia , Idoso , Amiloidose/complicações , Amiloidose/diagnóstico , Colite/diagnóstico , Colite/etiologia , Doenças do Colo/complicações , Doenças do Colo/diagnóstico , Doenças do Colo/patologia , Constrição Patológica , Feminino , Humanos , Perfuração Intestinal/diagnóstico , Perfuração Intestinal/etiologia , Complicações Pós-Operatórias/cirurgia , Reoperação , Estomas Cirúrgicos/patologia
15.
PLoS One ; 14(12): e0226032, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31790508

RESUMO

BACKGROUND: Early detection of postoperative increase in C-reactive protein (CRP) correlates with postoperative complications. The present study examined the association between preoperative / intraoperative factors and postoperative CRP levels, with development and validation of a prediction model of early postoperative CRP level, for prophylactic management of postoperative complications in patients undergoing surgery under general anesthesia. MATERIAL AND METHODS: Multivariate regression analysis was retrospectively performed to determine the independent factor of CRP levels on postoperative day (POD) 1 and to develop a prediction model. Validation of the prediction model was prospectively performed. Data from 316 adult patients on perioperative variables were retrospectively obtained in a training cohort in patients undergoing elective non-cardiac surgery. In a validation cohort, 88 patients undergoing mastectomy and 68 patients undergoing laparoscopic colon surgery were prospectively utilized to evaluate the value of the prediction model. Major complications after surgery were defined as the Clavien-Dindo grade IIIa or greater. RESULTS: Duration of surgery, mean nociceptive response (NR) during surgery as intraoperative nociception level, and preoperative CRP level were selected to set up the prediction model of CRP level on POD1 (P < 0.0001). In the validation cohort, the predicted CRP levels on POD1 significantly correlated with the measured CRP after mastectomy (P < 0.0001) and laparoscopic colon surgery (P = 0.0001). Receiver-operating characteristic curve analysis showed that the predicted CRP levels on POD1 was significantly associated with major complications after mastectomy (P = 0.0259) and laparoscopic colon surgery (P = 0.0049). The measured and predicted CRP levels significantly increased in the order of severity of postoperative complications (P < 0.01). CONCLUSION: Increases in duration of surgery, intraoperative nociceptive level and preoperative CRP level were selected to predict early increases in CRP level after non-cardiac surgery under general anesthesia. Predicted CRP levels on POD1 were likely associated with severity of postoperative complications.


Assuntos
Neoplasias da Mama/cirurgia , Proteína C-Reativa/metabolismo , Doenças do Colo/cirurgia , Laparoscopia/efeitos adversos , Mastectomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Idoso , Anestesia Geral , Área Sob a Curva , Neoplasias da Mama/patologia , Doenças do Colo/patologia , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Curva ROC , Estudos Retrospectivos , Índice de Gravidade de Doença
17.
Korean J Parasitol ; 57(4): 411-416, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31533408

RESUMO

To analyze the clinical and endoscopic features of colonic anisakiasis. A retrospective chart review of 20 patients with colonic anisakiasis, who were diagnosed by colonoscopy at 8 hospitals between January 2002 and December 2011, was performed. Patients' mean age was 53.6±10.74 years. Seventy percent patients were men. Acute abdominal pain was a common symptom that mostly developed within 48 hr after the ingestion of raw fish, and which lasted for 1-28 days. Sixty percent patients had ingested raw fish before the diagnosis of colonic anisakiasis and 40% patients were incidentally found to have colonic anisakiasis during the screening colonoscopies. Leukocytosis and eosinophilia were each found in 20% of the patients. In all patients who underwent colonoscopy, the worms were removed with biopsy forceps, except in 1 case, and a definite diagnosis of anisakiasis was made. In some cases of colonic anisakiasis, colonoscopy may be helpful in the diagnosis and treatment to avoid surgical intervention.


Assuntos
Anisaquíase/patologia , Doenças do Colo/patologia , Adulto , Idoso , Colonoscopia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Alimentos Crus/parasitologia , República da Coreia , Estudos Retrospectivos , Alimentos Marinhos/parasitologia
19.
Medicine (Baltimore) ; 98(33): e16846, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31415410

RESUMO

RATIONALE: Primary epiploic appendagitis (PEA) is a rare cause of acute abdomen caused by spontaneous torsion or venous thrombosis of epiploic appendices, it commonly manifests with acute lower quadrant pain, thus may mimic acute diverticulitis, appendicitis, or mesenteric infarction. PATIENT CONCERNS: In this case report, we report a 44 years old man who presented with persistent sharp pain in the left lower quadrant abdomen, Laboratory tests were mostly normal, contrast enhanced computed tomography (CECT) revealed a slightly high density shadow with fat foci in the middle was presented around the local descending colon, accompanied by the adjacent peritoneal thickening. DIAGNOSES: He was diagnosed with PEA as confirmed by an abdominal contrast enhanced computed tomography (CECT) scan. INTERVENTIONS: He was followed up in the clinic without any dietary restrictions, antibiotic or analgesic drugs use. OUTCOMES: The abdominal pain gradually subsided a week later, and there were no recurrence of the symptoms during follow-up. LESSONS: In our case, the diagnosis of PEA using CECT allows the patient to avoid surgery and other invasive treatment.


Assuntos
Abdome Agudo/diagnóstico , Colo Descendente/diagnóstico por imagem , Doenças do Colo/diagnóstico por imagem , Abdome Agudo/terapia , Adulto , Apendicite/diagnóstico , Colo Descendente/patologia , Doenças do Colo/patologia , Doenças do Colo/terapia , Tratamento Conservador , Diagnóstico Diferencial , Diverticulite/diagnóstico , Humanos , Masculino , Ultrassonografia Doppler em Cores
20.
BMJ Case Rep ; 12(7)2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31337625

RESUMO

We present the case of a 34-year-old woman who was diagnosed to have adenocarcinoma of the caecum based on the clinical, radiological, histopathological and intraoperative findings. However, postoperative histopathology showed only features of xanthogranulomatous inflammation without any evidence of malignancy. This benign chronic inflammatory condition could present as a histological surprise. It is important for both surgeons and pathologists alike to be aware of this.


Assuntos
Adenocarcinoma/patologia , Colo Ascendente/patologia , Doenças do Colo/patologia , Neoplasias do Colo/patologia , Erros de Diagnóstico , Granuloma/patologia , Inflamação/patologia , Xantomatose/patologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/cirurgia , Adulto , Biópsia , Colectomia , Doenças do Colo/diagnóstico , Neoplasias do Colo/diagnóstico , Neoplasias do Colo/cirurgia , Feminino , Granuloma/diagnóstico , Humanos , Inflamação/diagnóstico , Xantomatose/diagnóstico
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