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1.
Adv Exp Med Biol ; 1131: 131-161, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31646509

RESUMO

Calcium (Ca2+) is a fundamental regulator of cell fate and intracellular Ca2+ homeostasis is crucial for proper function of the nerve cells. Given the complexity of neurons, a constellation of mechanisms finely tunes the intracellular Ca2+ signaling. We are focusing on the sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) pump, an integral ER protein. SERCA's well established role is to preserve low cytosolic Ca2+ levels ([Ca2+]cyt), by pumping free Ca2+ ions into the ER lumen, utilizing ATP hydrolysis. The SERCA pumps are encoded by three distinct genes, SERCA1-3, resulting in 12 known protein isoforms, with tissue-dependent expression patterns. Despite the well-established structure and function of the SERCA pumps, their role in the central nervous system is not clear yet. Interestingly, SERCA-mediated Ca2+ dyshomeostasis has been associated with neuropathological conditions, such as bipolar disorder, schizophrenia, Parkinson's disease and Alzheimer's disease. We summarize here current evidence suggesting a role for SERCA in the neurobiology of neuropsychiatric and neurodegenerative disorders, thus highlighting the importance of this pump in brain physiology and pathophysiology.


Assuntos
Encéfalo , Retículo Endoplasmático , Doenças do Sistema Nervoso , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático , Encéfalo/enzimologia , Encéfalo/patologia , Retículo Endoplasmático/enzimologia , Regulação Enzimológica da Expressão Gênica , Homeostase , Humanos , Doenças do Sistema Nervoso/enzimologia , Doenças do Sistema Nervoso/fisiopatologia , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo
2.
J Assoc Physicians India ; 67(10): 80-82, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31571462

RESUMO

Dengue is the most common arboviral disease affecting many countries worldwide. With endemicity of the disease and huge burden, atypical clinical presentations occur posing high diagnostic and therapeutic dilemma. Emerging neurological complications in dengue fever are reported in recent past Acute disseminated encephalomyelitis (ADEM) is an immune mediated acute demyelinating disorder of the central nervous system following recent infection or vaccination and characterized by multifocal white matter involvement. Early suspicion and diagnosis of such complication is clinical dilemma and it further complicates the clinical scenario. This case report highlights occurrence of such uncommon manifestation of ADEM in commonly occurring dengue fever along with its diagnosis and successful management in a young individual.


Assuntos
Dengue , Encefalomielite Aguda Disseminada , Humanos , Imagem por Ressonância Magnética , Doenças do Sistema Nervoso , Vacinação
3.
Radiol Clin North Am ; 57(6): 1117-1131, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31582039

RESUMO

Various imaging techniques play a role in the diagnosis of CNS vasculopathies, which comprise a heterogeneous group of disorders, including various noninflammatory and inflammatory etiologies. Noninflammatory vasculopathies include entities such as CADASIL, Susac, moyamoya, fibromuscular dysplasia, vasculopathy of connective tissue disorders, and reversible vasoconstriction syndrome. Inflammatory vasculopathies include vasculitides of different vessel sizes, primary angiitis of the CNS, vasculitis of systemic disease, and vasculitis secondary to specific causes. Miscellaneous etiology includes cerebral amyloid angiopathy, which has noninflammatory and inflammatory subtypes. This article discusses important clinical and imaging findings used to distinguish these disorders.


Assuntos
Diagnóstico por Imagem/métodos , Doenças do Sistema Nervoso/diagnóstico por imagem , Doenças Vasculares/diagnóstico por imagem , Encéfalo/irrigação sanguínea , Encéfalo/diagnóstico por imagem , Humanos , Imagem por Ressonância Magnética , Tomografia Computadorizada por Raios X , Ultrassonografia
4.
Yi Chuan ; 41(9): 801-815, 2019 Sep 20.
Artigo em Chinês | MEDLINE | ID: mdl-31549679

RESUMO

Development of the human brain is a strictly complex and precisely regulated process. Brain development includes the proliferation and differentiation of neural progenitor cells, migration and maturation of neurons, myelination of neuronal axons, synaptogenesis and organization of the neural circuits. Abnormalities of these developmental processes can lead to severe malformation and dysfunction of the brain, which may result in brain developmental diseases which have a high medical burden and have attracted global attention. Brain developmental diseases are typically divided into two categories according to abnormal brain morphology and dysfunction: malformation of cortical development (MCD) and neuropsychopathy. Microcephaly and autism spectrum disorder (ASD) are representative disorders of MCD and neuropsychopathy respectively. In this review, we summarize the progresses of these two typical and relevant brain developmental diseases including the mechanism and etiology of their development, gene expression, symptoms, and related to provide theoretical guidance for basic research and management and treatment.


Assuntos
Encéfalo/fisiopatologia , Deficiências do Desenvolvimento/fisiopatologia , Doenças do Sistema Nervoso/patologia , Doenças do Sistema Nervoso/psicologia , Transtorno do Espectro Autista/fisiopatologia , Humanos , Microcefalia/fisiopatologia , Neurogênese , Neurônios
5.
Herzschrittmacherther Elektrophysiol ; 30(3): 245-250, 2019 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-31486879

RESUMO

Not only can cardiac diseases have neurological sequelae, but neurological diseases can also affect the heart. In this paper, the effects of a primary neurological disease on the heart are reviewed. Rare genetic muscular disorders, systemic neurodegenerative diseases, special neurological syndromes and sequelae of brain disease are discussed. A case vignette is used to illustrate that an undiagnosed neurological disease can trigger cardiac disease. Brain imaging should therefore always be considered in cardiac disease.


Assuntos
Cardiopatias , Doenças do Sistema Nervoso , Humanos
7.
Stomatologiia (Mosk) ; 98(4): 89-92, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31513157

RESUMO

The aim of the study was to determine the relationship between the background on-life drug therapy of psychoneurological disorders with dental pathology in children by analyzing the characteristics of pharmacotherapy and the physical characteristics of the oral fluid. The study involved 277 children with psychoneurological disorders and 270 children without comorbid pathology. The deterioration of the physical characteristics of the oral fluid in children with psychoneurological pathology associated with the experience of comorbid disease and drug therapy for the comorbid background has been established.


Assuntos
Transtornos Mentais/complicações , Doenças da Boca , Doenças do Sistema Nervoso , Criança , Humanos , Doenças da Boca/psicologia , Doenças do Sistema Nervoso/complicações
8.
Orv Hetil ; 160(37): 1447-1454, 2019 Sep.
Artigo em Húngaro | MEDLINE | ID: mdl-31495190

RESUMO

Myotonic dystrophy is one of the most common, autosomal dominantly inherited adult-onset muscle disorders. Two types of the disease are known: type 1 is characterized by distal weakness and myotonia, but type 2 is associated with proximal weakness and milder clinical course. It is also called as Steinert Disease, which affects the heart conduction system, the internal secretional glands, the ocular lens as well as carbohydrate-, fat metabolism and gonadal functions. These systemic symptoms have high impact on the quality of life and might impact on patients' survival. Here we would like to emphasize these clinical conditions and the diagnostic possibilities. We hope our recommendations can help neurologists and general practitioners to achieve an optimal and individual care for patients suffering from this muscle disease. Orv Hetil. 2019; 160(37): 1447-1454.


Assuntos
Sistema de Condução Cardíaco/fisiopatologia , Distrofia Miotônica/diagnóstico , Adulto , Catarata/genética , Humanos , Resistência à Insulina/genética , Músculos/fisiopatologia , Distrofia Miotônica/complicações , Distrofia Miotônica/genética , Doenças do Sistema Nervoso , Qualidade de Vida , Expansão das Repetições de Trinucleotídeos
9.
Toxicol Lett ; 315: 96-106, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31386889

RESUMO

We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral outcomes of rats. Two hundred Wistar rats were divided into four groups, two control groups, a vitamin sufficient control group and a vitamin deficiency control group and 2 test groups, a vitamin sufficient test group, and a vitamin deficiency group. The test groups were exposed for 9 months to a mixture of diquat, imazamox, imazethapyr, tepraloxydin, bentazone and acifluorfen in doses of 0.01xNOAEL (mg/kg bw/day). After 9 months of exposure, the behavior changes were evaluated by open field test and elevated plus maze test and the memory was assessed by passive avoidance test. Chronic vitamin deficiency decreased locomotor and special orientation activity and increased anxiety-like behavior in rats. Exposure to very low doses of a mixture of 6 pesticides caused central nervous effects, manifested as decreased locomotor activity, and increased anxiety levels. Vitamin deficiency and low dose chronic pesticides mixture exposure thus affected the central nervous system, especially long-term memory.


Assuntos
Deficiência de Vitaminas/complicações , Deficiência de Vitaminas/fisiopatologia , Aprendizagem da Esquiva/efeitos dos fármacos , Aprendizagem em Labirinto/efeitos dos fármacos , Doenças do Sistema Nervoso/induzido quimicamente , Doenças do Sistema Nervoso/fisiopatologia , Praguicidas/toxicidade , Animais , Modelos Animais de Doenças , Masculino , Ratos , Ratos Wistar
10.
Sheng Li Xue Bao ; 71(4): 657-670, 2019 Aug 25.
Artigo em Chinês | MEDLINE | ID: mdl-31440763

RESUMO

The neuropeptide orexin is widely distributed in the nervous system. Previous studies showed that orexin is involved in the feeding behavior regulation by binding to its receptor 1 (OX1R) and receptor 2 (OX2R) to activate the downstream signaling pathway. Recent studies have demonstrated that the system of orexin and its receptors are also involved in important physiological processes such as sleep-wake, learning and memory, and pathological processes of various neurological diseases. In this review, we summarized the research progress on the function of the orexin and its receptor system in physiological and pathological processes, and revealed the correlation between orexin and nervous system diseases, in order to provide the theoretical guidance for the diagnosis and treatment of the related diseases in the future.


Assuntos
Doenças do Sistema Nervoso/fisiopatologia , Receptores de Orexina/fisiologia , Orexinas/fisiologia , Humanos , Transdução de Sinais
11.
Nervenarzt ; 90(8): 843-857, 2019 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-31375848

RESUMO

Chronic neurodegenerative and neuroinflammatory diseases, such as idiopathic Parkinson's syndrome, amyotrophic lateral sclerosis and multiple sclerosis, represent a therapeutic challenge. Their pathophysiology is not well understood and a cure for any of these diseases is not possible. Over the past decades lifestyle and nutritional habits in modern industrial nations have changed and evidence is increasing that the prevalence of chronic diseases as well their clinical presentation are also changing. Epidemiological investigations indicate that nutritional components might have an impact on the pathogenesis of chronic neurological diseases. A profound understanding of these correlations could foster a better prevention as well as treatment of such chronic disabling diseases. This continuing medical education article summarizes the current understanding of selected nutritional components and their effect on the development and clinical course of chronic neurological disorders.


Assuntos
Doenças do Sistema Nervoso , Doença Crônica , Humanos , Doenças do Sistema Nervoso/dietoterapia , Doenças do Sistema Nervoso/prevenção & controle
12.
Stud Health Technol Inform ; 264: 1876-1877, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31438387

RESUMO

Patients with nervous system disorders with an accurate nursing assessment can experience an improved prognosis and promotion of health. The lack of uniform terminology limits the accuracy of nursing in China. ICF constitutes a unified and standard language can help standardize nursing assessment terms. This study show that ICF is suitable for Chinese nursing practice by using ICF Clinical Checklist and ICF-linking-rules to map the nursing assessment terminology of neurological conditions with ICF.


Assuntos
Doenças do Sistema Nervoso , Atividades Cotidianas , China , Avaliação da Deficiência , Humanos , Classificação Internacional de Funcionalidade, Incapacidade e Saúde , Avaliação em Enfermagem
13.
West Afr J Med ; 36(2): 183-188, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31385606

RESUMO

OBJECTIVE: There is paucity of information on delirium in sub-Saharan Africa (SSA) particularly in the older persons (>60 years of age), leaving questions about the burden of the disease in an environment with lower health care standards. In this article, we set out to determine the frequency, precipitants and symptomatology of delirium in elderly patients admitted into medical wards in a teaching hospital in South-West Nigeria. METHODS: This was a descriptive study involving a pre-planned sample of one hundred and fifty patients aged 60 years and over, assessed for cognitive impairment and delirium using the previously validated IDEA cognitive screen, and the Confusion Assessment Method (CAM) respectively. Diagnosis of delirium was made using the CAM and DSM-IV criteria. RESULTS: Delirium was diagnosed in 32 patients giving a frequency of 21.3% (95%CI: 14.7-30.0%). Patients with delirium were significantly older (p<0.05). A quarter of the patients had dementia. Hypertension was a notable co-morbid condition. All the patients had altered sleep wake cycle, inattention, disorientation, and altered consciousness. Neurological diseases were the most common precipitant. There was a good agreement between the DSM-IV and CAM diagnoses. CONCLUSION: Delirium is common in hospitalised elderly patients particularly those with neurological diseases. Co-morbidities like hypertension, dementia, and depression should be looked for in delirious elderly patients.


Assuntos
Disfunção Cognitiva/diagnóstico , Confusão/diagnóstico , Delírio/diagnóstico , Demência/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Disfunção Cognitiva/epidemiologia , Comorbidade , Confusão/psicologia , Delírio/epidemiologia , Delírio/psicologia , Demência/epidemiologia , Manual Diagnóstico e Estatístico de Transtornos Mentais , Humanos , Hipertensão/epidemiologia , Entrevista Psiquiátrica Padronizada/estatística & dados numéricos , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/epidemiologia , Testes Neuropsicológicos/estatística & dados numéricos , Nigéria/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Centros de Atenção Terciária
15.
Artigo em Russo | MEDLINE | ID: mdl-31407678

RESUMO

AIM: To characterize the clinical picture, infectious etiology and MRI results of panencephalitis (PANE) in children, depending on the duration of the disease. MATERIAL AND METHODS: Children (n=32) with PANE at the age from 3 months up to 17 years were examined for a group of actual viral and bacterial infections. The inclusion criterion was a diffuse lesion of white matter hemispheres on MRI. MRI of the brain and spinal cord, CSF study (pleocytosis, oligoclonal IgG, the main myelin protein (MBP) were performed. The follow-up was 5-10 years. The complex therapy included etiotropic (antiviral) and pathogenetic agents, with priority given to cytoflavin as a drug with a multimodal effect. RESULTS: In 84.4% of cases, PANE in children are recorded under the age of 3 years and in 71.9% of cases, are associated with congenital infections with the prevalence of herpes viruses, especially cytomegalovirus (37,8%) and herpes type 6 (21.9%). In 78.3% of cases, PANE have chronic gradual development more often with a delay in the formation of motor and speech/prespeech skills, and manifested with pyramidal, cerebellar and other symptoms in the future. PANE is accompanied by a lesion of the white matter of the hemispheres in 1/2 cases with periventricular localization, less often in infratentorial structures (46.9%) and spinal cord (21.9%). With the duration of symptoms up to 3 months (n=22) PANE are characterized by inflammatory-demyelinating changes, signs of mass effect, contrast+, pleocytosis in CSF and the increase in MBP (average 4.2±0.8 ng/ml), and, with the duration of more than 3 months, by degenerative-sclerosing changes (n=10) and CSF oligoclonal IgG in 90% of cases. CONCLUSION: In almost 2/3 of cases, PANE are associated with congenital infections, accompanied by extensive symmetrical foci of demyelination in the CNS, and their clinical and laboratory parameters and outcomes depend on the start of treatment, with the positive dynamics in 75% of cases.


Assuntos
Doenças Desmielinizantes , Doenças do Sistema Nervoso , Adolescente , Encéfalo/diagnóstico por imagem , Criança , Pré-Escolar , Doenças Desmielinizantes/diagnóstico por imagem , Humanos , Lactente , Imagem por Ressonância Magnética , Doenças do Sistema Nervoso/diagnóstico por imagem , Bandas Oligoclonais , Adulto Jovem
16.
Wiad Lek ; 72(7): 1288-1294, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31398157

RESUMO

OBJECTIVE: Introduction: General anaesthesia is carried out using anaesthetic agents that among others depress the circulatory system and CNS. Central and peripheral thermoregulation occurs, which is due to mild hypothermia as well as changes in skin moisture. An important element of therapy in the perioperative period is adequate intravenous fluid therapy, which affects the final effects of treatment. The aim: Evaluation of skin moisture as a result of changes in central and peripheral thermoregulation during general anaesthesia and evaluation of the hydration status of patients. PATIENTS AND METHODS: Material and methods: The study included 180 patients undergoing general anaesthesia for elective surgery, aged 20-85 years of age. Before general anaesthesia, patients were evaluated for ASA-related risk of anaesthesia (ASA 1 - healthy patients, ASA 2 and 3 - patients with neurological and circulatory disorders). Patients were divided into 2 groups, the study group (90 people) were patients who were given no intravenous fluids before the surgery and the control group (90 patients) were those receiving doses of 500 ml crystalline intravenously one hour before anaesthesia. The research was carried out at the Operational Block of the Provincial Hospital in Tarnobrzeg, from November 2013 to November 2014. Skin moisture was measured using a CM 825 Corneometer: before general anaesthesia, after induction for anaesthesia, 15 min after surgical incision of the skin and after awakening the patient. RESULTS: Results: Both in the test and control groups, statistically significant differences were found in subsequent skin moisture measurements. Pairwise comparisons indicate statistically significant differences between each pair of measurements. In both groups of patients, there is a clear decrease in skin moisture after induction of anaesthesia compared to the measurement performed before general anaesthesia. The skin moisture values are reduced in subsequent measurements, however the difference is much lower. CONCLUSION: Conclusions: 1 Measurement of skin moisture can be used as one of the parameters to assess perioperative stress and changes in body temperature during general anaesthesia, which indirectly determines the functioning of the hypothalamus. 2 By measuring the skin moisture it is possible to indirectly assess the hydration status of patients as well as the decrease of the metabolism during general anaesthesia. 3 The decrease in skin moisture during general anaesthesia is the effect of changes in central and peripheral thermoregulation.


Assuntos
Anestesiologia , Doenças do Sistema Nervoso , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia Geral , Humanos , Pessoa de Meia-Idade , Adulto Jovem
17.
Surg Clin North Am ; 99(5): 955-965, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31446920

RESUMO

Surgeons are often asked to perform tracheostomies and percutaneous endoscopic gastrostomies for a wide variety of patients. As consultants, surgeons are tasked with honoring the relationship between the referring provider and the patient while also assessing whether the consult is appropriate given the patient's prognosis and goals of care. This article discusses the most common conditions for which these procedures are requested and reviews the evidence supporting either the placement or avoidance of these tubes in each condition. It provides a framework for surgeons to use when discussing these procedures in the context of goals of care.


Assuntos
Endoscopia Gastrointestinal , Nutrição Enteral , Neoplasias de Cabeça e Pescoço/cirurgia , Doenças do Sistema Nervoso/cirurgia , Traqueostomia , Ferimentos e Lesões/cirurgia , Estado Terminal/terapia , Endoscopia Gastrointestinal/efeitos adversos , Endoscopia Gastrointestinal/mortalidade , Humanos , Cuidados Paliativos/ética , Traqueostomia/efeitos adversos , Traqueostomia/mortalidade
18.
Rev. med. (Säo Paulo) ; 98(4): 279-289, jul.-ago. 2019.
Artigo em Inglês | LILACS | ID: biblio-1023539

RESUMO

Noninvasive brain stimulation therapies are a promising field for the development of new protocols for the treatment of neuropsychiatric disorders. They are based on the stimulation of neural networks with the intent of modeling their synaptic activity to adequate levels. For this, it is necessary to precisely determine which networks are related to which brain functions, and the normal activation level of each of these networks, so that it is possible to direct the stimulation to the affected networks in order to induce the desired effects. These relationships are under intense investigation by the scientific community, and will contribute to the advancement of treatments by neurostimulation, with the emergence of increasingly accurate and effective protocols for different disorders. Currently, the most used techniques are Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation, with the most common applications being for treating Major Depressive Disorder. The advancement of research in this field may determine new target networks for stimulation in the treatment of other disorders, extending the application of these techniques and also our knowledge about brain functioning.


As terapias biológicas não invasivas se apresentam como um campo promissor para o desenvolvimento de novos protocolos de tratamento de transtornos neuropsiquiátricos. Elas se baseiam na estimulação de redes neurais com intuito de modular sua atividade sináptica para níveis adequados. Para isso, é necessário a determinação precisa de quais redes estão relacionadas a quais funções cerebrais, e do nível de ativação normal de cada uma dessas redes, para que então seja possível direcionar a estimulação às redes afetadas a fim de induzir os efeitos desejados. Essas relações estão sob intensa investigação pela comunidade científica, e vão contribuir para o avanço dos tratamentos por neuroestimulação, com o surgimento de protocolos cada vez mais precisos e efetivos para diferentes transtornos. Atualmente, as técnicas mais utilizadas são a Estimulação Transcraniana por Corrente Contínua e a Estimulação Magnética Transcraniana, sendo a aplicação mais comum no tratamento do Transtorno Depressivo Maior. O avanço das pesquisas possivelmente determinará novas redes alvo para estimulação no tratamento de outros transtornos, estendendo a aplicação dessas técnicas e também do nosso conhecimento sobre o funcionamento cerebral.


Assuntos
Estimulação Magnética Transcraniana/normas , Neuroestimuladores Implantáveis , Neuropsiquiatria , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/terapia
19.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46671

RESUMO

O controle do bruxismo depende do grau de seriedade e deve ser feito em conjunto entre dentistas, médicos e psicólogos. Entre as formas de tratamento para o bruxismo, é comum a indicação de uso de placas estabilizadoras, medicamentos, acupuntura.


Assuntos
Bruxismo , Bruxismo do Sono , Transtornos de Ansiedade , Transtorno do Espectro Autista , Doenças do Sistema Nervoso , Desgaste dos Dentes , Síndrome da Disfunção da Articulação Temporomandibular , Estresse Psicológico , Qualidade de Vida , Psicoterapia
20.
Artigo em Russo | MEDLINE | ID: mdl-31317900

RESUMO

An accurate diagnosis of the existing defect of motor function in patients with neurological pathology is necessary for the optimal formulation of the rehabilitation program, selection of drug therapy and evaluation of the effectiveness of treatment. In current clinical practice, clinical scales such as the Dynamic Gait Index, the Rivermid Mobility Index, the Hauser Walk Index, the Stand Up and Go Test, the MDS-UPDRS III are used most often to assess walking function. Evaluation of walking function using valid scales is very accessible, however, it has such a disadvantage as subjectivity. That's why the study of motor functions by instrumental methods gains more prominence. The most well-known methods of objective walking assessment include an analysis of human movements using accelerometers, three-dimensional video analysis, sub-metric, goniometric and impregnation methods. Each of these methods has both advantages and disadvantages. The main requirement to objective methods of assessing walking functions in neurological pathology is the universality of the complex (the accuracy of measurements, regardless of the type of walking disorder), the ability to determine both temporal and spatial characteristics of the step, the ease of use. Considering these requirements, the use of the 'Induction Analyzer of the kinematic parameters of walking' seems promising in the diagnosis of motor disorders.


Assuntos
Marcha , Doenças do Sistema Nervoso , Caminhada , Fenômenos Biomecânicos , Humanos , Doenças do Sistema Nervoso/diagnóstico , Amplitude de Movimento Articular
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