Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 92
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Zoo Wildl Med ; 50(2): 461-465, 2019 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-31260215

RESUMO

Congenital hypothyroidism (CH) in humans is most commonly caused by disruption of thyroid gland development (dysgenesis) or an inherited defect in thyroid hormone biosynthesis (dyshormonogenesis). CH has not been previously documented in great apes. This report describes the clinical presentation, diagnosis, and treatment of CH in a 9-mo-old male Bornean orangutan (Pongo pygmaeus) and a 6-wk-old female Sumatran orangutan (Pongo abelii). Primary CH due to thyroid dysgenesis was confirmed in the Bornean orangutan using sonography and radioisotope scintigraphy. Although commercial thyroid immunoassays are not validated for use in orangutans, in comparison to age-matched controls, thyroid-stimulating hormone level was markedly elevated, and serum thyroxine (T4) and free T4 levels were markedly decreased in both cases. Oral supplementation with levothyroxine sodium resulted in noticeable clinical improvement in both orangutans within 30 days of initiating treatment.


Assuntos
Doenças dos Símios Antropoides/congênito , Hipotireoidismo Congênito/veterinária , Pongo/classificação , Tiroxina/uso terapêutico , Envelhecimento , Animais , Doenças dos Símios Antropoides/tratamento farmacológico , Doenças dos Símios Antropoides/patologia , Hipotireoidismo Congênito/diagnóstico , Hipotireoidismo Congênito/tratamento farmacológico , Feminino , Masculino , Especificidade da Espécie , Tireotropina/sangue , Tiroxina/sangue
2.
PLoS One ; 14(6): e0218763, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31242268

RESUMO

Cardiac disease is a major cause of morbidity and mortality for adult gorillas. Previous research indicates a sex-based difference with predominantly males demonstrating evidence of left ventricular hypertrophy. To evaluate these findings, we analyzed serum markers with cardiac measures in a large sample of gorillas. The study sample included 44 male and 25 female gorillas housed at American Association of Zoo and Aquariums (AZA)-accredited zoos. Serum samples were collected from fasted gorillas during routine veterinary health exams and analyzed to measure leptin, adiponectin, IGF-1, insulin, ferritin, glucose, triglycerides, and cholesterol. Cardiac ultrasonography via transthoracic echocardiogram was performed simultaneously. Three echocardiographic parameters were chosen to assess cardiac disease according to parameters established for captive lowland gorillas: left ventricular internal diameter, inter-ventricular septum thickness, and left ventricular posterior wall thickness. Our data revealed that high leptin, low adiponectin, and lowered cholesterol were significantly and positively correlated with measures of heart thickness and age in males but not in females. Lowered cholesterol in this population would be categorized as elevated in humans. High leptin and low adiponectin are indicative of increased adiposity and suggests a potential parallel with human obesity and cardiovascular disease in males. Interestingly, while females exhibited increased adiposity with age, they did not progress to cardiac disease.


Assuntos
Adiposidade , Doenças dos Símios Antropoides/patologia , Gorilla gorilla , Cardiopatias/veterinária , Adiponectina/sangue , Animais , Animais de Zoológico , Doenças dos Símios Antropoides/sangue , Doenças dos Símios Antropoides/etiologia , Biomarcadores/sangue , Colesterol/sangue , Feminino , Gorilla gorilla/anatomia & histologia , Gorilla gorilla/sangue , Cardiopatias/sangue , Cardiopatias/patologia , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/patologia , Leptina/sangue , Masculino , Fatores de Risco , Fatores Sexuais
3.
J Wildl Dis ; 55(2): 298-303, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30284944

RESUMO

Mountain gorillas ( Gorilla beringei beringei) are one of the most critically endangered great apes in the world. The most common cause of mountain gorilla morbidity and mortality is trauma (e.g., injury from conspecifics or snare entrapment). We conducted a retrospective case-control study of free-ranging, human-habituated mountain gorillas to evaluate factors associated with snare entrapment and the results of clinical intervention. Data were collected from clinical records on all clinical intervention cases ( n=132) in Volcanoes National Park, Rwanda, conducted between 1995-2015. Wildlife veterinarians treated 37 gorillas entrapped in snares and 95 gorillas for other clinical conditions (including trauma and respiratory illness). Multivariate statistical analyses revealed that young gorillas (<8 yr old) were more likely than older gorillas to become snared; that comorbidities delayed times to intervention (≥3 d); and that severity of wounds at the time of intervention were associated with increased risk of lasting impairment (including loss of limb or limb function, or death) within 1 mo after intervention. Our results may influence decisions for gorilla health monitoring and treatment to most effectively conserve this critically endangered species.


Assuntos
Doenças dos Símios Antropoides/patologia , Gorilla gorilla/lesões , Ferimentos e Lesões/veterinária , Envelhecimento , Animais , Doenças dos Símios Antropoides/epidemiologia , Estudos de Casos e Controles , Espécies em Perigo de Extinção , Feminino , Masculino , Parques Recreativos , Estudos Retrospectivos , Ruanda/epidemiologia
4.
J Zoo Wildl Med ; 49(3): 828-832, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30212342

RESUMO

A 47-yr-old multiparous female bonobo ( Pan paniscus) tested positive for pregnancy on a routine urine test. Because this geriatric animal was considered postreproductive, oral contraception had been discontinued. Sequential transabdominal ultrasound evaluations were performed under voluntary behavior and revealed that the uterus contained a mass of heterogenous tissue which was rapidly increasing in size. Due to a lack of normal fetal development and the ultrasonographic appearance of the uterine tissue, a molar pregnancy was suspected. Ovariohysterectomy was performed, and a complete hydatidiform mole was confirmed through human chorionic gonadotropin levels as well as gross and histological examination of the uterus. To the authors' knowledge, this is the first time a complete molar pregnancy has been reported antemortem in a nonhuman great ape, although a single case of partial hydatidiform mole was previously documented in a chimpanzee on postmortem examination. This case describes the successful medical and surgical management of complete molar pregnancy in a bonobo and provides support for extending the age range of birth control recommendations in geriatric captive great apes that exhibit active breeding behavior.


Assuntos
Doenças dos Símios Antropoides/cirurgia , Mola Hidatiforme/veterinária , Pan paniscus , Animais , Animais de Zoológico , Doenças dos Símios Antropoides/patologia , Feminino , Mola Hidatiforme/patologia , Mola Hidatiforme/cirurgia , Gravidez
5.
Int J Paleopathol ; 21: 47-55, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29778414

RESUMO

The reported incidence of neoplasia in the extinct hominin record is rare. We describe here the first palaeopathological analysis of an osteogenic lesion in the extinct hominin Homo naledi from Dinaledi Cave (Rising Star), South Africa. The lesion presented as an irregular bony growth, found on the right lingual surface of the body of the adult mandible U.W. 101-1142. The growth was macroscopically evaluated and internally imaged using micro-focus x-ray computed tomography (µCT). A detailed description and differential diagnosis were undertaken using gross and micromorphology, and we conclude that the most probable diagnosis is peripheral osteoma - a benign osteogenic neoplasia. These tumours are cryptic in clinical expression, though they may present localised discomfort and swelling. It has been suggested that muscle traction may play a role in the development and expression of these tumours. The impact of this lesion on the individual affected is unknown. This study adds to the growing corpus of palaeopathological data from the South African fossil record, which suggests that the incidence of neoplastic disease in deep prehistory was more prevalent than traditionally accepted. The study also highlights the utility of micro-computed tomography in assisting accurate diagnoses of ancient pathologies.


Assuntos
Doenças dos Símios Antropoides/história , Doenças dos Símios Antropoides/patologia , Fósseis/patologia , Neoplasias Mandibulares/veterinária , Osteoma/veterinária , Animais , Doenças dos Símios Antropoides/diagnóstico por imagem , Fósseis/diagnóstico por imagem , História Antiga , Hominidae , Microtomografia por Raio-X
6.
Vet Ophthalmol ; 21(2): 199-204, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28058762

RESUMO

CASE DESCRIPTION: A 17-year-old female western lowland gorilla presented with bilateral ocular discharge, conjunctivitis, and rhinitis that was investigated and treated over a 34-month period. Clinical findings, diagnostic results, treatment, and follow-up are described. CLINICAL FINDING: A mild intermittent mucoid ocular discharge was initially noted. 10 months later, conjunctival hyperemia and thickening developed and progressed rapidly to a mass-like lesion covering the right eye. Hematology revealed eosinophilia. Conjunctival cytology revealed eosinophils and neutrophils, and histopathology revealed a chronic proliferative eosinophilic conjunctivitis. 21 months after, the ocular lesions were investigated the gorilla developed masses within both external nares. Histopathology of the nasal lesions revealed chronic-active eosinophilic rhinitis. TREATMENT AND OUTCOME: Treatment of the gorilla was based on protocols recommended for human patients. Protocols for mild, moderate, and finally severe disease were used, involving topical and oral combinations of treatments. The gorilla eventually responded to systemic immunosuppressant therapy recommended for severe refractory disease. CLINICAL SIGNIFICANCE: To the authors' knowledge, this is the first reported case of vernal-like conjunctivitis in a western lowland gorilla.


Assuntos
Doenças dos Símios Antropoides/patologia , Conjuntivite Alérgica/veterinária , Gorilla gorilla , Animais , Antibacterianos/uso terapêutico , Doenças dos Símios Antropoides/diagnóstico , Doenças dos Símios Antropoides/terapia , Conjuntivite Alérgica/diagnóstico , Conjuntivite Alérgica/terapia , Feminino , Rinite/diagnóstico , Rinite/terapia , Rinite/veterinária
7.
Sci Rep ; 7(1): 15224, 2017 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-29123202

RESUMO

The genus Pan is the closest related to humans (Homo sapiens) and it includes two species: Pan troglodytes (chimpanzees) and Pan paniscus (bonobos). Different characteristics, some of biomedical aspect, separate them from us. For instance, some common human medical conditions are rare in chimpanzees (menopause, Alzheimer disease) although it is unclear to which extent longevity plays an active role in these differences. However, both humans and chimpanzees present similar pathologies, thus, understanding traits in chimpanzees can help unravel the molecular basis of human conditions. Here, we sequenced the genome of Nico, a central chimpanzee diagnosed with a particular biomedical condition, the Chiari malformation. We performed a variant calling analysis comparing his genome to 25 whole genomes from healthy individuals (bonobos and chimpanzees), and after predicting the effects of the genetic variants, we looked for genes within the OMIM database. We found a novel, private, predicted as damaging mutation in Nico in LRP5, a gene related to bone density alteration pathologies, and we suggest a link between this mutation and his Chiari malformation as previously shown in humans. Our results reinforce the idea that a comparison between humans and chimpanzees can be established in this genetic frame of common diseases.


Assuntos
Doenças dos Símios Antropoides/genética , Doenças dos Símios Antropoides/patologia , Malformação de Arnold-Chiari/genética , Malformação de Arnold-Chiari/patologia , Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética , Mutação , Animais , Masculino , Pan troglodytes , Sequenciamento Completo do Genoma
8.
Sci Rep ; 7(1): 14581, 2017 11 06.
Artigo em Inglês | MEDLINE | ID: mdl-29109465

RESUMO

Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because - in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes.


Assuntos
Doenças dos Símios Antropoides/microbiologia , Pan troglodytes/microbiologia , Infecções Pneumocócicas/veterinária , Streptococcus pneumoniae , Animais , Animais Selvagens/microbiologia , Animais de Zoológico/microbiologia , Doenças dos Símios Antropoides/patologia , Doenças dos Símios Antropoides/transmissão , Camarões , Costa do Marfim , Feminino , Pulmão/microbiologia , Pulmão/patologia , Infecções Pneumocócicas/microbiologia , Infecções Pneumocócicas/patologia , Infecções Pneumocócicas/transmissão , Streptococcus pneumoniae/patogenicidade
9.
J Zoo Wildl Med ; 48(2): 540-543, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28749298

RESUMO

An 18-yr-old female Western lowland gorilla ( Gorilla gorilla gorilla) presented with acute-onset severe lethargy, bloody vaginal discharge, decreased appetite, and an abnormal posture. The gorilla was diagnosed with a ruptured cecal blind sac with severe adhesions to the right ovary. A typhlectomy and unilateral ovariectomy were performed. Histologic examination identified a severe transmural circumferential typhlitis with rupture and adhesions to the infundibulum and chronic typhlitis. Postoperative management included antibiotics, analgesics, short-term dietary modifications, and probiotics for suspect oral candidiasis. The gorilla made a full clinical recovery and was pregnant within 1 yr of surgery. To the authors' knowledge, this is the first case of successful management of typhlitis in a gorilla. Typhlitis and intestinal rupture should be considered as a differential diagnosis for acute onset severe abdominal pain in gorillas.


Assuntos
Doenças dos Símios Antropoides/patologia , Ceco/lesões , Gorilla gorilla , Perfuração Intestinal/veterinária , Peritonite/veterinária , Animais , Doenças dos Símios Antropoides/terapia , Ceco/patologia , Feminino , Perfuração Intestinal/cirurgia , Peritonite/etiologia , Peritonite/microbiologia , Peritonite/terapia , Infecções Estreptocócicas/microbiologia , Infecções Estreptocócicas/veterinária
10.
J Med Primatol ; 46(5): 271-290, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28543059

RESUMO

We present the spontaneous pathological lesions identified as a result of necropsy or biopsy for 245 chimpanzees (Pan troglodytes) over a 35-year period. A review of the pathology database was performed for all diagnoses on chimpanzees from 1980 to 2014. All morphologic diagnoses, associated system, organ, etiology, and demographic information were reviewed and analyzed. Cardiomyopathy was the most frequent lesion observed followed by hemosiderosis, hyperplasia, nematodiasis, edema, and hemorrhage. The most frequently affected systems were the gastrointestinal, cardiovascular, urogenital, respiratory, and lymphatic/hematopoietic systems. The most common etiology was undetermined, followed by degenerative, physiologic, neoplastic, parasitic, and bacterial. Perinatal and infant animals were mostly affected by physiologic etiologies and chimpanzee-induced trauma. Bacterial and physiologic etiologies were more common in juvenile animals. Degenerative and physiologic (and neoplastic in geriatric animals) etiologies predominated in adult, middle aged, and geriatric chimpanzees.


Assuntos
Doenças dos Símios Antropoides/patologia , Pan troglodytes , Animais , Doenças dos Símios Antropoides/epidemiologia , Doenças dos Símios Antropoides/etiologia , Biópsia/veterinária , Incidência
11.
J Zoo Wildl Med ; 48(1): 224-227, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28363069

RESUMO

An adult male Bornean orangutan ( Pongo pygmaeus ) was diagnosed with invasive, poorly differentiated grade 9/9 mammary gland adenocarcinoma from a subcutaneous mass that was surgically removed during a routine preventative health examination. The tumor was tested for estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2), and HER2 fluorescence in situ hybridization (HER2 FISH). Whole blood was tested for breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. The orangutan was treated orally with two common human breast cancer drugs; tamoxifen and anastrozole. The orangutan lived for 4.5 yr postdetection, dying from an unrelated cause. This is the first reported case of mammary gland adenocarcinoma in a male great ape.


Assuntos
Adenocarcinoma/veterinária , Doenças dos Símios Antropoides/diagnóstico , Neoplasias Mamárias Animais/diagnóstico , Pongo pygmaeus , Adenocarcinoma/diagnóstico , Adenocarcinoma/patologia , Adenocarcinoma/terapia , Anastrozol , Animais , Antineoplásicos Hormonais/uso terapêutico , Doenças dos Símios Antropoides/tratamento farmacológico , Doenças dos Símios Antropoides/patologia , Doenças dos Símios Antropoides/cirurgia , Masculino , Neoplasias Mamárias Animais/tratamento farmacológico , Neoplasias Mamárias Animais/patologia , Neoplasias Mamárias Animais/cirurgia , Neoplasias Hormônio-Dependentes/diagnóstico , Neoplasias Hormônio-Dependentes/patologia , Neoplasias Hormônio-Dependentes/terapia , Neoplasias Hormônio-Dependentes/veterinária , Nitrilos/uso terapêutico , Tamoxifeno/uso terapêutico , Triazóis/uso terapêutico
12.
J Zoo Wildl Med ; 48(4): 1264-1266, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29297793

RESUMO

A 57-yr-old female Sumatran orangutan ( Pongo abelii) presented with signs of intermittent lethargy and inappetence, then subsequently developed profuse hemorrhagic diarrhea. Colonoscopy under anesthesia revealed diverticulosis of the descending colon, with multiple large diverticula containing fecoliths. There was no evidence of diverticulitis, but a regenerative anemia had developed following an acute diverticular bleed. The orangutan recovered with conservative therapy. Colonic diverticulosis has been reported in nonhuman primates and appears to have a similar clinical presentation to the condition as it occurs in humans. This is the first published report of colonic diverticulosis in a great ape.


Assuntos
Doenças dos Símios Antropoides/patologia , Divertículo/veterinária , Hemorragia Gastrointestinal/veterinária , Pongo abelii , Animais , Animais de Zoológico , Divertículo/patologia , Feminino , Hemorragia Gastrointestinal/patologia
13.
J Zoo Wildl Med ; 47(3): 697-710, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27691977

RESUMO

Wild bonobos (Pan paniscus), chimpanzees (Pan troglodytes), Western gorillas (Gorilla gorilla), and orangutans (Pongo pygmaeus, Pongo abelii) are threatened with extinction. In order to help maintain a self-sustaining zoo population, clinicians require a sound understanding of the diseases with which they might be presented. To provide an up-to-date perspective on great ape morbidity and mortality, a systematic review of the zoological and veterinary literature of great apes from 1990 to 2014 was conducted. This is the first review of the great ape literature published since 1990 and the first-ever systematic literature review of great ape morbidity and mortality. The following databases were searched for relevant articles: CAB Abstracts, Web of Science Core Collection, BIOSIS Citation Index, BIOSIS Previews, Current Contents Connect, Data Citation Index, Derwent Innovations Index, MEDLINE, SciELO Citation Index, and Zoological Record. A total of 189 articles reporting on the causes of morbidity and mortality among captive great apes were selected and divided into comparative morbidity-mortality studies and case reports-series or single-disease prevalence studies. The content and main findings of the morbidity-mortality studies were reviewed and the main limitations identified. The case reports-case series and single-disease prevalence studies were categorized and coded according to taxa, etiology, and body system. Subsequent analysis allowed the amount of literature coverage afforded to each category to be calculated and the main diseases and disorders reported within the literature to be identified. This review concludes that reports of idiopathic and infectious diseases along with disorders of the cardiovascular, respiratory, and gastrointestinal body systems were particularly prominent within the great ape literature during 1990-2014. However, recent and accurate prevalence figures are lacking and there are flaws in those reviews that do exist. There is therefore a critical need for a robust, widespread, and more up-to-date review of mortality among captive great apes.


Assuntos
Doenças dos Símios Antropoides/mortalidade , Doenças dos Símios Antropoides/patologia , Hominidae , Animais
14.
J Med Primatol ; 45(6): 336-341, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27506330

RESUMO

BACKGROUND: Crescentic glomeruli are the hallmark finding in rapidly progressive glomerulonephritis (RPGN) and are characterized by disruption and proliferation of the glomerular capsule and an influx of cells into Bowman's space. Pauci-immune-type RPGN is identified by a lack of immunoglobulins and immune complexes in the glomerular basement membrane. METHODS: Complete necropsy and histology were performed on the affected chimpanzee. Electron microscopy was performed on kidney sections. A search of the literature was performed to identify spontaneous RPGN in animals. RESULTS: We report a case of crescentic glomerulonephritis of the pauci-immune-type in a hepatitis C virus-infected 28-year-old male chimpanzee (Pan troglodytes) who was humanely euthanized for a cardiac-related decline in health. CONCLUSION: To our knowledge, this is the first report describing pauci-immune crescentic glomerulonephritis in a non-human primate.


Assuntos
Doenças dos Símios Antropoides , Glomerulonefrite/veterinária , Pan troglodytes , Animais , Animais Domésticos , Animais de Zoológico , Doenças dos Símios Antropoides/diagnóstico , Doenças dos Símios Antropoides/patologia , Glomerulonefrite/classificação , Glomerulonefrite/diagnóstico , Glomerulonefrite/patologia , Masculino
15.
J Zoo Wildl Med ; 47(1): 347-50, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27010300

RESUMO

A 31-yr-old male Sumatran orangutan (Pongo abelii) presented with 14 yr of chronic purulent nasal drainage and cough with intermittent exacerbation of symptoms requiring systemic antibiotic treatment. He was diagnosed with a cystic fibrosis (CF)-like condition. Evaluation consisted of bronchoscopy with bronchoalveolar lavage, culture, and computed tomography scanning of the sinuses and chest. Although the presence of low fecal elastase activity increased the suspicion for a diagnosis of CF, pilocarpine iontophoresis with sweat collection and analysis ("sweat testing") was inconclusive. Medical management included twice-daily nebulization with bronchodilators and alternating month inhaled antibiotics, pancreatic enzyme replacement therapy, and simethicone as needed. Sinopulmonary and gastrointestinal symptoms improved substantially with treatment. Several years later, the animal died acutely of colonic volvulus. Necropsy and histopathology confirmed CF-like lung disease with chronic air sacculitis.


Assuntos
Doenças dos Símios Antropoides/patologia , Bronquiectasia/veterinária , Fibrose Cística/veterinária , Pongo abelii , Sinusite/veterinária , Albuterol/administração & dosagem , Albuterol/uso terapêutico , Animais , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Doenças dos Símios Antropoides/diagnóstico , Bronquiectasia/diagnóstico , Bronquiectasia/tratamento farmacológico , Bronquiectasia/patologia , Broncodilatadores/administração & dosagem , Broncodilatadores/uso terapêutico , Fibrose Cística/diagnóstico , Fibrose Cística/patologia , Masculino , Sinusite/diagnóstico , Sinusite/tratamento farmacológico , Sinusite/patologia
17.
Vet Pathol ; 53(2): 250-76, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26721908

RESUMO

The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia. Cerebral vascular disease occurs in both humans and apes. Cardiovascular disease mortality increases in aging humans and apes, but coronary atherosclerosis is the most significant type in humans. In captive apes, idiopathic myocardial fibrosis and cardiomyopathy predominate, with arteriosclerosis of intramural coronary arteries. Similar cardiac lesions are occasionally seen in wild apes. Vascular changes in heart and kidneys and aortic dissections in gorillas and bonobos suggest that hypertension may be involved in pathogenesis. Chronic kidney disease is common in elderly humans and some aging apes and is linked with cardiovascular disease in orangutans. Neoplasms common to aging humans and apes include uterine leiomyomas in chimpanzees, but other tumors of elderly humans, such as breast, prostate, lung, and colorectal cancers, are uncommon in apes. Among the apes, chimpanzees have been best studied in laboratory settings, and more comparative research is needed into the pathology of geriatric zoo-housed and wild apes. Increasing longevity of humans and apes makes understanding aging processes and diseases imperative for optimizing quality of life in all the ape species.


Assuntos
Envelhecimento/patologia , Doenças dos Símios Antropoides/patologia , Hominidae , Animais , Gorilla gorilla , Humanos , Pan paniscus , Pan troglodytes , Pongo , Qualidade de Vida
18.
Vet Pathol ; 53(2): 417-24, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26792841

RESUMO

Cardiorenal syndrome involves disease and dysfunction of the heart that leads to progressive renal dysfunction. This study investigated the relationship between cardiac and renal disease in 91 aged chimpanzees at the Alamogordo Primate Facility by evaluation of the medical histories, metabolic parameters, functional measurements of the cardiovascular system, clinical pathology, and histopathology focused on the heart and kidney. Cardiac fibrosis was the most frequent microscopic finding in 82 of 91 animals (90%), followed by glomerulosclerosis with tubulointerstitial fibrosis in 63 of 91 (69%). Cardiac fibrosis with attendant glomerulosclerosis and tubulointerstitial fibrosis was observed in 58 of 91 animals (63%); there was a statistically significant association between the 2 conditions. As the severity of cardiac fibrosis increased, there was corresponding increase in severity of glomerulosclerosis with tubulointerstitial fibrosis. Altered metabolic, cardiovascular, and clinical pathology parameters indicative of heart and kidney failure were commonly associated with the moderate to severe microscopic changes, and concurrent heart and kidney failure were considered the cause of death. The constellation of findings in the chimpanzees were similar to cardiorenal syndrome in humans.


Assuntos
Doenças dos Símios Antropoides/patologia , Síndrome Cardiorrenal/veterinária , Rim/patologia , Miocárdio/patologia , Pan troglodytes , Animais , Síndrome Cardiorrenal/patologia , Feminino , Fibrose/patologia , Fibrose/veterinária , Humanos , Masculino , Estudos Retrospectivos
19.
Vet Pathol ; 53(2): 425-35, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26823448

RESUMO

Chimpanzees (Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions in aging chimpanzees. In this article, the authors present histopathologic descriptions of lesions identified in the reproductive tract, including the mammary gland, of 33 female and 34 male aged chimpanzees from 3 captive populations. The most common findings in female chimpanzees were ovarian atrophy, uterine leiomyoma, adenomyosis, and endometrial atrophy. The most common findings in male chimpanzees were seminiferous tubule degeneration and lymphocytic infiltrates in the prostate gland. Other less common lesions included an ovarian granulosa cell tumor, cystic endometrial hyperplasia, an endometrial polyp, uterine artery hypertrophy and mineralization, atrophic vaginitis, mammary gland inflammation, prostatic epithelial hyperplasia, dilated seminal vesicles, a sperm granuloma, and lymphocytic infiltrates in the epididymis. The findings in this study closely mimic changes described in the reproductive tract of aged humans, with the exception of a lack of malignant changes observed in the mammary gland and prostate gland.


Assuntos
Envelhecimento/patologia , Doenças dos Símios Antropoides/patologia , Doenças dos Genitais Femininos/veterinária , Doenças dos Genitais Masculinos/veterinária , Pan troglodytes , Animais , Modelos Animais de Doenças , Feminino , Doenças dos Genitais Femininos/patologia , Doenças dos Genitais Masculinos/patologia , Genitália/patologia , Humanos , Masculino , Estudos Retrospectivos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA