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2.
J Law Med ; 27(4): 779-789, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32880397

RESUMO

The COVID-19 pandemic has created an environment highly conducive to substandard and fraudulent research. The incentives and temptations for the unethical are substantial. The articles published during 2020 in The Lancet and the New England Journal of Medicine that were based on spurious datasets, allegedly hosted by a cloud-based health care analytics platform, are deeply confronting for research integrity. They illustrate the perils of precipitate publication, inadequate peer-reviewing and co-authorship without proper assumption of responsibility. A period of crisis such as that in existence during the COVID-19 pandemic calls for high-quality research that is robustly evaluated. It is not a time for panic to propel premature publication or for relaxation in scholarly standards. Any other approach will replicate errors of the past and result in illusory research breakthroughs to global detriment.


Assuntos
Pesquisa Biomédica , Infecções por Coronavirus , Pandemias , Pneumonia Viral , Má Conduta Científica , Autoria , Betacoronavirus , Humanos , Editoração
3.
Acta Biomed ; 91(3): e2020020, 2020 09 07.
Artigo em Inglês | MEDLINE | ID: mdl-32921717

RESUMO

COVID-19 first presented in Wuhan, Hubei Province, China in December 2019. Since then, it has rapidly spread across the world, and is now formally considered a pandemic. As of 4th of May more than 3.2 million people have been infected and over 250,000 people has died. Since the very start, scientists and researchers have tried to utilize this case to publish academic experiences and suggestions toward fighting this virus, which is lethal in some cases. To date, more than 9,000 academic papers have been published since December 2019. The quality of publications varies from a plane letter to editor to randomized studies. This review aims to analyse the current published literature related to COVID-19 and assess the quality of such articles.


Assuntos
Betacoronavirus , Infecções por Coronavirus/epidemiologia , Pandemias , Publicações Periódicas como Assunto/tendências , Pneumonia Viral/epidemiologia , Editoração/organização & administração , Humanos
4.
Pediatrics ; 146(3)2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32868469
5.
S Afr Med J ; 110(8): 756-758, 2020 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-32880302

RESUMO

The COVID-19 pandemic has had a major impact on research at universities. Universities around the world, including in South Africa, have been or are still closed as part of national lockdown strategies. Students have not been attending classes or doing hands-on experimental work, and students and academics have been working from home. Many thousands of students have had their university education interrupted, and for them, the resumption of learning programmes online, and where possible in research laboratories, is critically important. There is no question that as we emerge from lockdown we will not be entering a world that resembles a 'norm' as lived in the pre-COVID-19 era, and many changes will be required. Here we discuss the importance of research, the urgency to get things up and running again, and strategies that will need to be implemented to ensure that research activities continue. At the same time, it is necessary to ensure that students and staff are not exposed to risk in their research endeavours, which will require the development and implementation of risk management plans.


Assuntos
Pesquisa Biomédica , Controle de Doenças Transmissíveis , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Pesquisadores/educação , Universidades , Betacoronavirus , Educação a Distância , Humanos , Laboratórios , Pandemias , Editoração , Pesquisa , África do Sul/epidemiologia , Estudantes
10.
PLoS Med ; 17(9): e1003344, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32956352

RESUMO

BACKGROUND: Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size and, consequently, power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging because of poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies that has been developed using a widely accepted robust methodology. The objective of this project was to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline. METHODS AND FINDINGS: We established a preliminary checklist of reporting items to be considered for inclusion in the guideline. We invited representatives of key stakeholder groups to participate in a 2-round Delphi survey. A total of 52 individuals participated in both rounds of the survey, scoring items with regards to their importance for inclusion in the STROPS guideline. We then held a consensus meeting, at which 8 individuals considered the results of the Delphi survey and voted on whether each item ought to be included in the final guideline. The STROPS guideline consists of 54 items and is accompanied by an explanation and elaboration document. The guideline contains items that are particularly important in the field of pharmacogenetics, such as the drug regimen of interest and whether adherence to treatment was accounted for in the conducted analyses. The guideline also requires that outcomes be clearly defined and justified, because in pharmacogenetic studies, there may be a greater number of possible outcomes than in other types of study (for example, disease-gene association studies). A limitation of this project is that our consensus meeting involved a small number of individuals, the majority of whom are based in the United Kingdom. CONCLUSIONS: Our aim is for the STROPS guideline to improve the transparency of reporting of pharmacogenetic studies and also to facilitate the conduct of high-quality systematic reviews and meta-analyses. We encourage authors to adhere to the STROPS guideline when publishing pharmacogenetic studies.


Assuntos
Farmacogenética/métodos , Testes Farmacogenômicos/normas , Testes Farmacogenômicos/tendências , Adulto , Lista de Checagem , Consenso , Técnica Delfos , Feminino , Estudos de Associação Genética , Objetivos , Humanos , Masculino , Pessoa de Meia-Idade , Farmacogenética/normas , Política , Editoração/normas , Projetos de Pesquisa/normas , Participação dos Interessados , Inquéritos e Questionários , Reino Unido
14.
Chirurgia (Bucur) ; 115(4): 432-440, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32876016

RESUMO

One of the main goals of clinicians is to constantly improve the healthcare by spreading their expertise and by introducing innovations in medical science. Therefore, publishing is of utmost importance. Moreover, publishing helps authors in developing their academic carrier. Learning how to properly write and submit a manuscript should be a goal for all medical students, residents, clinicians and researchers. Everyone, from students to senior physicians and surgeons, advance in their carrier by publishing papers and by getting their work cited by others. The aim of this paper, published in three parts, is to enable the readers to write and publish their work effectively; the current part is addressing the actual writing process of a clinical paper.


Assuntos
Pesquisa Biomédica , Editoração , Humanos , Redação
15.
S Afr Med J ; 110(8): 753-755, 2020 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-32880301

RESUMO

The research requirement for South African specialist registration offers opportunities and challenges. For some clinicians it may spark a lifelong interest in clinical investigation, while for many others it may provide a potential publication opportunity. Integrating the specific requirements of an MMed mini-dissertation with those of standard medical publications can be difficult for first-time authors and their supervisors; published guidance caters to full-length laboratory Master's or doctoral research. We suggest that research is more likely to be publishable if it is locally relevant, has a clear clinical message and is coherently presented.


Assuntos
Dissertações Acadêmicas como Assunto , Educação de Pós-Graduação em Medicina , Editoração , Pesquisa Biomédica , Humanos , África do Sul , Especialização
16.
S Afr Med J ; 110(7): 640-641, 2020 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-32880339

RESUMO

The basis of a manuscript is the research question, which is reported within a standard publication structure. The 'Background' section clarifies the question. The 'Methods' section describes what was done in the study. The 'Results' section describes the data observed and the analysis of these data. The 'Discussion' section describes how findings of the study relate to current knowledge and the practical implications of the results, and suggests future studies. This structure differs from that of a thesis, the aims of which are broader than reporting on a specific research question.


Assuntos
Revisão da Pesquisa por Pares , Editoração , Humanos , Publicações Periódicas como Assunto , Projetos de Pesquisa
18.
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