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1.
Prensa méd. argent ; 105(5): 309-316, jun 2019. tab, fig
Artigo em Inglês | LILACS, BINACIS | ID: biblio-1024643

RESUMO

Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present. However, significant side effects are associated with them, and there is a need for a search for other tretment options. This study was aimed to assess the contribution of niclosamide in experimentally established colitis in rats. Animals were categorized into 5 groups; the control group undergoes no induction of UC, colitis group in which UC was induced, and animals receive no treatment, the niclosamide group that received niclosamide and sulfasalazine group that received sulfasalazine. Each group was composed of 10 animals. After the completion of a one-month period of the experiment animals were sacrificed and the following meausres were done: the weight of the colon, determination of the area of mucosal damage by mm2, histological scoring after hematoxylin and eosin stain together with MAC score and immunohistochemistry of IL-6, TNF-alpha, MPO, MDA, CD62, and ICAM1. The results of the current study revealed that Nicosamide was able to reduce the area of mucosal damage, colon weight, histological and Mac scores and immunohistochemical scores of inflammatory and oxidative markers, significantly when contrasted to a group of colitis (P< 0.05). It has been concluded that Niclosamide was proved to have a significant effect as an adjuvant mode of therapy for colitis through its, anti-inflamatory and anti-oxidant effects (AU)


Assuntos
Ratos , Sulfassalazina/uso terapêutico , Colite Ulcerativa/terapia , Efeito Secundário , Avaliação de Resultado de Intervenções Terapêuticas , Epidemiologia Experimental , Tempo para o Tratamento , Abate de Animais , Niclosamida/uso terapêutico
2.
INSPILIP ; 2(1): 1-13, ene.-jun. 2018.
Artigo em Inglês | LILACS | ID: biblio-987247

RESUMO

Latent tuberculosis infection is a major health problem worldwide. People with latent tuberculosis infection have a lifetime risk of developing active tuberculosis approximately 5 % to 10%. Patients with latent tuberculosis infection were infected with Mycobacterium tuberculosis. Therefore, early diagnosis and treatment of a latent tuberculosis infection are very important. Patients with latent tuberculosis infection do not have the symptoms, signs, radiographic, and bacteriological evidence of active tuberculosis. Consequently, these patients are not contagious to others. Patients with latent tuberculosis infection usually have a positive tuberculin skin test or interferon-gamma release assays test. Systematic testing is recommended for all patients that are at risk for latent tuberculosis infection. The treatment of latent tuberculosis is recommended for patients that are at increased risk for developing active tuberculosis. The medications recommended to treat latent tuberculosis infection are isoniazid, rifampin, and a combination of isoniazidand rifapentine, and isoniazid and rifampin combination regimens. The most common side effect of these medications is hepatotoxicity. Therefore, patient monitoring during treatment should occur every month to evaluate medications side effects and adherence to medications. Post-treatment patient follow-up is very important, but serial or repeats chest radiography is not recommended.


La infección de tuberculosis latente es un gran problema de salud a nivel mundial. Las personas con infección de tuberculosis latente tienen un riesgo de desarrollar tuberculosis activa en aproximadamente 5 % a 10 % en toda su vida. Pacientes con infección de tuberculosis latente fueron infectados con Mycobacterium tuberculosis, por lo tanto, diagnóstico y tratamiento temprano de la infección de tuberculosis latente es muy importante. Pacientes con infección de tuberculosis latente son asintomáticos, no tienen signos físicos o radiográficos anormales, y no tienen evidencia bacteriológica de tuberculosis activa. Consecuentemente, estos pacientes no son contagiosos a otras personas. Pacientes con infección de tuberculosis latente usualmente son positivos para las pruebas de la tuberculina o Interferon-Gamma Release Assays. Pruebas sistemáticas son recomendadas para todos los pacientes que están en riesgo de presentar infección de tuberculosis latente. El tratamiento de tuberculosis latente es recomendado para los pacientes que tienen un elevado riesgo de desarrollar tuberculosis activa. Los medicamentos recomendados para el tratamiento de la infección de tuberculosis latente son isoniacida, rifampicina, y una combinación de isoniacida y rifapentin, y la combinación de isoniacida y rifampicina. El efecto secundario más común de estos medicamentos es hepatotoxicidad. Por lo tanto, la monitorización de estos pacientes durante el tratamiento debería ser cada mes, para evaluar efectos secundarios de los medicamentos y la adherencia al tratamiento. Es muy importante dar seguimiento después del tratamiento, pero hacer radiografías repetidas de pulmones no es recomendado.


Assuntos
Humanos , Pacientes , Tuberculina , Saúde , Risco , Tuberculose Latente , Efeito Secundário , Radiografia Pulmonar de Massa
3.
Rev. bras. hematol. hemoter ; 39(1): 4-12, Jan.-Mar. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-843954

RESUMO

Abstract Background: Secondary myeloid neoplasms comprise a group of diseases arising after chemotherapy, radiation, immunosuppressive therapy or from aplastic anemia. Few studies have addressed prognostic factors in these neoplasms. Method: Forty-two patients diagnosed from 1987 to 2008 with secondary myeloid neoplasms were retrospectively evaluated concerning clinical, biochemical, peripheral blood, bone marrow aspirate, biopsy, and immunohistochemistry and cytogenetic features at diagnosis as prognostic factors. The International Prognostic Scoring System was applied. Statistical analysis employed the Kaplan–Meier method, log-rank and Fisher's exact test. Results: Twenty-three patients (54.8%) were male and the median age was 53.5 years (range: 4–88 years) at diagnosis of secondary myeloid neoplasms. Previous diseases included hematologic malignancies, solid tumors, aplastic anemia, autoimmune diseases and conditions requiring solid organ transplantations. One third of patients (33%) were submitted to chemotherapy alone, 2% to radiotherapy, 26% to both modalities and 28% to immunosuppressive agents. Five patients (11.9%) had undergone autologous hematopoietic stem cell transplantation. The median latency between the primary disease and secondary myeloid neoplasms was 85 months (range: 23–221 months). Eight patients were submitted to allogeneic hematopoietic stem cell transplantation to treat secondary myeloid neoplasms. Important changes in bone marrow were detected mainly by biopsy, immunohistochemistry and cytogenetics. The presence of clusters of CD117+ cells and p53+ cells were associated with low survival. p53 was associated to a higher risk according to the International Prognostic Scoring System. High prevalence of clonal abnormalities (84.3%) and thrombocytopenia (78.6%) were independent factors for poor survival. Conclusion: This study demonstrated that cytogenetics, bone marrow biopsy and immunohistochemistry are very important prognostic tools in secondary myeloid neoplasms.


Assuntos
Humanos , Masculino , Feminino , Adulto , Síndromes Mielodisplásicas , Segunda Neoplasia Primária , Efeito Secundário , Análise de Sobrevida
5.
Rev Panam Salud Publica ; 39(6),jun. 2016
Artigo em Espanhol | PAHO-IRIS | ID: phr-28541

RESUMO

Objetivo. Diseñar y validar una encuesta para conocer las causas de tipo administrativo que pueden influir en la baja notificación de reacciones adversas a medicamentos (RAM). Métodos. El cuestionario se diseñó a partir de una revisión bibliográfica y una tormenta de ideas. Las variables que se consideraron que pueden influir en la notificación fueron la carga de trabajo de los profesionales y su percepción del control de la actividad de farmacovigilancia. Para su validación, se encuestó a 60 profesionales de una muestra de conveniencia. La confiabilidad se calculó con la alfa de Cronbach y el coeficiente de Kuder Richardson. La validez de contenido se cuantificó con el coeficiente de Kendall y la de criterio, mediante la concordancia con el criterio establecido. Resultados. El cuestionario tipo encuesta quedó constituido por 15 preguntas y estructurado en dos partes, información general y causas administrativas de la baja notificación de RAM. La alfa de Cronbach fue 0,87, el coeficiente de Kuder Richardson, 0,9033, y la validez total, 1,51, resultante de 70% de concordancia y un coeficiente de correlación por rangos de 0,81. Conclusiones. La confiabilidad de la encuesta validada fue aceptable-elevada y su validez, aceptable.


Objective. Design and validate a survey to determine the administrative causes that can influence low reporting of adverse drug reactions. Methods. The questionnaire design was based on a review of the literature and on brainstorming. The variables considered to influence reporting were professional workload and the professional perception of drug surveillance control activities. To validate the hypothesis, 60 professionals were surveyed in a convenience sample. Reliability was calculated using Cronbach’s alfa and the Kuder-Richardson coefficient. Content validity was measured using the Kendall coefficient, and criterion validity, through concordance with the established criterion. Results. The survey-type questionnaire was composed of 15 questions divided into two parts: general information and administrative causes of low adverse drug reactions reporting. Cronbach’s alfa was 0.87, the Kuder-Richardson coefficient was 0.9033, and overall validity was 1.51, resulting from 70% concordance and a rank correlation coefficient of 0.81. Conclusions. The reliability of the validated survey was acceptable to high and validity was acceptable.


Assuntos
Efeito Secundário , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Farmacovigilância , Cuba , Efeito Secundário , Farmacovigilância , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
8.
Arch. Soc. Esp. Oftalmol ; 90(12): 588-592, dic. 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-145848

RESUMO

CASO CLÍNICO: Miope magna con cámara anterior estrecha que presentó cierre angular secundario a lorazepam. DISCUSIÓN: El cierre angular generalmente ocurre en pacientes predispuestos desencadenado por factores precipitantes. Muchos fármacos de uso rutinario en la práctica clínica podrían ejercer como factor responsable del cierre angular secundario


CASE REPORT: Myopic magna with narrow anterior chamber that presented with a secondary angle closure due to lorazepam. DISCUSSION: Angle closure usually occurs in predisposed patients and is triggered by precipitating factors. Many drugs routinely used in clinical practice could act as a factor responsible for the secondary angle closure


Assuntos
Adulto , Feminino , Humanos , Miopia/induzido quimicamente , Miopia/complicações , Lorazepam/efeitos adversos , Lorazepam/uso terapêutico , Efeito Secundário , Visão Ocular , Transtornos da Visão/induzido quimicamente , Transtornos da Visão/complicações , Tomografia de Coerência Óptica/métodos , Pressão Intraocular , Acetazolamida/uso terapêutico , Soluções Oftálmicas/uso terapêutico , Fundo de Olho , Tomografia de Coerência Óptica/instrumentação , Tomografia de Coerência Óptica
10.
Aten. prim. (Barc., Ed. impr.) ; 46(7): 357-366, ago.-sept. 2014. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-128674

RESUMO

OBJETIVO: Conocer la adherencia al tratamiento en pacientes que inician fármacos antidepresivos y analizar los factores asociados al incumplimiento, tanto clínicos como sociodemográficos. DISEÑO: Estudio observacional longitudinal prospectivo. Emplazamiento: Consultas de atención primaria y de salud mental de tres áreas sanitarias de Castilla-La Mancha. Participantes: Un total de 185 pacientes mayores de 18 años que iniciaron tratamiento antidepresivo. Mediciones principales: Cumplimiento terapéutico (test Haynes-Sackett, Morisky-Green, recuento de comprimidos y MEMS), efectos adversos, intensidad de los síntomas depresivos, características sociodemográficas y otras características relacionadas con los antidepresivos o con los participantes. RESULTADOS: Tras 6 meses del inicio del tratamiento antidepresivo, el 46,9% (IC 95%: 36,5-57,3) mostró un cumplimiento inadecuado mediante el método de recuento de comprimidos, y el 28,6% (IC 95%: 19,1-38,0) con el cuestionario de Morisky-Green. A los 15 días la falta de adherencia fue del 48,5% (IC 95%: 40,6-56,4) y del 33,5% (IC 95%: 26,1-41,0), respectivamente. El 38,4% (IC 95%: 31,1-45,7) manifestó algún efecto secundario durante el seguimiento. Mediante un modelo de riesgos proporcionales de Cox las variables relacionadas con incumplimiento fueron menor edad, nivel de instrucción inferior a enseñanza secundaria, prestación farmacéutica como pensionista, no recibir tratamiento psicoterápico, consumir menor número de fármacos no antidepresivos y frecuentación ≤ 3 visitas al médico de familia los 3 meses previos al inicio del estudio. CONCLUSIONES: El incumplimiento del tratamiento antidepresivo es elevado en atención primaria desde las primeras semanas tras iniciarlo. Constituyen factores condicionantes del mismo los relacionados con características sociodemográficas y con otras características de los pacientes como tipo de financiación de prestación farmacéutica y frecuentación a las consultas


OBJETIVE: To know the adherence to treatment in patients who initiate antidepressant drugs and to analyze the determinant factors of non-compliance, so much clinical as sociodemographic. DESIGN: Prospective longitudinal observational study. Location: Primary Health Care and Mental Health Surgeries of three Castilla-La Mancha Areas. Participants: 185 adults patients who were started in antidepressant treatment were evaluated. Measurements: Treatment adherence (test Haynes-Sackett, test Morisky-Green, count of tablets and MEMS), adverse effects, intensity of depressive symptoms, sociodemographic characteristics and other characteristics related to antidepressants or participants. RESULTS: After 6 months of beginning antidepressing treatment, 46.9% (95% IC: 36.5-57.3) showed an inadequate fulfilment by pill count method and 28.6% (95% IC: 19.1-38.0) with Morisky-Green's questionnaire. To 15 days the lack of adherence was 48.5% (95% IC: 40.6-56.4) and of 33.5% (95% IC: 26.1-41.0). The 38.4% (95% IC: 31.1-45.7) demonstrated some side effect during the follow-up. Using proportional risk model of Cox the variables related to compliance were: younger age, level of instruction lower than secondary studies, free medicines for pensioner, no psychotherapeutic treatment, consume a fewer antidepressants drugs and a frequency ≤ 3 visits to the family doctor 3 months previous to the study. CONCLUSIONS: The non-compliance of antidepressant treatment in primary care is high from the first weeks after initiating it. The conditioning factors are related to sociodemographic characteristics and other patient characteristics as type of financing of pharmaceutical benefit and frequentness at primary care


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Adesão à Medicação/estatística & dados numéricos , Depressão/tratamento farmacológico , Depressão/epidemiologia , Depressão/prevenção & controle , Antidepressivos/uso terapêutico , Tratamento Secundário/métodos , Tratamento Secundário/prevenção & controle , Efeito Secundário/métodos , Efeito Secundário/normas , Atenção Primária à Saúde/métodos , Atenção Primária à Saúde/tendências , Saúde Mental , Inquéritos e Questionários , Psicoterapia/métodos , Psicoterapia/tendências , Indicadores de Morbimortalidade , Estudos Prospectivos
11.
Lima; s.n; 2014. 52 p. ilus, tab, graf.
Tese em Espanhol | Peru nacional | ID: pnc-17765

RESUMO

El presente estudio titulado: "Validación de una Guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros en el Servicio de Especialidades Médicas y Quimioterapia", tuvo como objetivo determinar la Validación de una guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros. Material y Método: El estudio es de nivel aplicativo, tipo cuantitativo, método descriptivo de corte transversal. La población estuvo conformado por 20 enfermeros, la técnica fue la encuesta y el instrumento fue la guía de cuidados y un opinionario aplicado previo consentimiento informado Resultados: Del 100 por ciento (20), 70 por ciento (14) tienen una opinión favorable y 30 por ciento (6) no favorable. Conclusión: La Validación de la guía de cuidados según la opinión de la mayoría de enfermeros es favorable, en cuanto al contenido y estructura, lo cual permitirá brindar información importante del paciente oncológico en tratamiento con quimioterapia sobre los efectos secundarios post quimioterapia. (AU)


This study entitled: "Validation of a care guide for the management and control of the side effects post chemotherapy according to nurses at the service of medical specialties and chemotherapy", aimed to determine the validation of a care guide for the management and control of side effects post chemotherapy according to nurses. Material and method: The study is application level, quantitative, descriptive cross-sectional method. The population was comprised of 20 nurses, the technique was the survey and instruments a care guide and an opinionario applied prior informed consent results: 100 per cent (20), 70 per cent (14) have a favorable opinion and 30 per cent (6) not favorable. Conclusion: The validation of the care guide according to the opinion of the majority of nurses is favorable, in terms of content and structure, enabling you to provide important information for the cancer patient in treatment with chemotherapy side effects post chemotherapy. (AU)


Assuntos
Tratamento Farmacológico , Efeito Secundário , Guia de Prática Clínica , Cuidados de Enfermagem , Estudos de Avaliação como Assunto , Estudos Transversais
12.
Lima; s.n; 2014. 52 p. ilus, tab, graf.
Tese em Espanhol | LILACS, LIPECS | ID: lil-757745

RESUMO

El presente estudio titulado: "Validación de una Guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros en el Servicio de Especialidades Médicas y Quimioterapia", tuvo como objetivo determinar la Validación de una guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros. Material y Método: El estudio es de nivel aplicativo, tipo cuantitativo, método descriptivo de corte transversal. La población estuvo conformado por 20 enfermeros, la técnica fue la encuesta y el instrumento fue la guía de cuidados y un opinionario aplicado previo consentimiento informado Resultados: Del 100 por ciento (20), 70 por ciento (14) tienen una opinión favorable y 30 por ciento (6) no favorable. Conclusión: La Validación de la guía de cuidados según la opinión de la mayoría de enfermeros es favorable, en cuanto al contenido y estructura, lo cual permitirá brindar información importante del paciente oncológico en tratamiento con quimioterapia sobre los efectos secundarios post quimioterapia...


This study entitled: "Validation of a care guide for the management and control of the side effects post chemotherapy according to nurses at the service of medical specialties and chemotherapy", aimed to determine the validation of a care guide for the management and control of side effects post chemotherapy according to nurses. Material and method: The study is application level, quantitative, descriptive cross-sectional method. The population was comprised of 20 nurses, the technique was the survey and instruments a care guide and an opinionario applied prior informed consent results: 100 per cent (20), 70 per cent (14) have a favorable opinion and 30 per cent (6) not favorable. Conclusion: The validation of the care guide according to the opinion of the majority of nurses is favorable, in terms of content and structure, enabling you to provide important information for the cancer patient in treatment with chemotherapy side effects post chemotherapy...


Assuntos
Cuidados de Enfermagem , Efeito Secundário , Guia de Prática Clínica , Tratamento Farmacológico , Estudos de Avaliação como Assunto , Estudos Transversais
13.
Int. j. high dilution res ; 13(49): 207-226, 2014.
Artigo em Inglês | HomeoIndex - Homeopatia | ID: hom-11054

RESUMO

Using the empirical or phenomenological research method by observing the effects of drugs in the human physiology, Samuel Hahnemann proposed the homeopathic treatment. He synthesized modern pharmacodynamic in the ‘primary action’ of the drugs and in the consequent and opposite ‘secondary action’ or ‘vital reaction’ of the organism. Noting that drugs with ‘contrary’ primary action to the symptoms of the diseases caused worsening of the symptoms after its withdrawal, as a result of secondary action of the organism, Hahnemann proposed using this vital reaction (secondary action) in a curative way, administering to sick individuals the drugs that caused‘similar’ symptoms in healthy individuals (therapeutic use of the similitude principle). According to the clinical and experimental pharmacology, this secondary action (vital reaction) of the organism is observed in the ‘rebound effect’ or ‘paradoxical reaction’ of several classes of drugs, which is the scientific basis of the ‘homeopathic pharmacology’. In the last decade, exponents of modern pharmacology have suggested the therapeutic use of the paradoxical reaction(‘paradoxical pharmacology’), proposing the use of drugs that cause an exacerbation of the disease in the short term to treat these same diseases in the long-term. In this review, we compare the various aspects between the ‘homeopathic pharmacology’ and the ‘paradoxical pharmacology’, reinforcing the validity of homeopathic assumptions and expanding the knowledge to optimize both proposals.(AU)


Assuntos
Efeito Rebote , Ação Farmacodinâmica do Medicamento Homeopático , Farmacologia , Efeito Secundário , Terapêutica Homeopática , Farmacologia Clínica/métodos , Lei dos Semelhantes/métodos
14.
Rev. med. (Säo Paulo) ; 92(3): 183-203, jul.-set. 2013.
Artigo em Português | LILACS | ID: lil-730798

RESUMO

O modelo homeopático de tratamento das doenças utiliza o ‘princípio da semelhança’ como método terapêutico, empregando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curentur), com o intuito de estimular uma reação curativa do organismo contra os seus próprios distúrbios. Esta reação secundária (vital, homeostática ou paradoxal) do organismo está fundamentada no estudo do ‘efeito rebote’ dos fármacos modernos, evento adverso que pode causar transtornos graves após a descontinuação de diversas classes de tratamentos convencionais que utilizam o ‘princípio dos contrários’ como prática terapêutica (contraria contrariis curentur). Embora o fenômeno rebote seja um evento adverso estudado pela farmacologia moderna, ele é desconhecido pelos profissionais da saúde, privando a classe médica de um conhecimento necessário e fundamental ao manejo seguro dos fármacos. Apesar de se expressar numa pequena proporção de indivíduos suscetíveis, o efeito rebote assume importância epidemiológica em vista do enorme consumo de medicamentos pela população e da falta de esclarecimentos sobre o fenômeno. Este artigo apresenta uma revisão atualizada sobre o efeito rebote das drogas, relacionando-o ao princípio de cura homeopático.


The homeopathic model of treatment of diseases uses the ‘principle of similarity’ as therapeutic method, employing drugs that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curentur), seeking to stimulate a healing reaction of the organism against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the organism is based on the study of the ‘rebound effect’ of modern drugs, iatrogenic event that can cause serious disorders after the discontinuation of several classes of conventional treatments that use the ‘principle of contraries’ as therapeutic practice (contraria contrariis curentur). Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is unknown by health professionals, depriving the medical class of a necessary and fundamental knowledge to the safe management of drugs. Despite expressing itself in a small proportion of susceptible individuals, the rebound effect assumes epidemiological importance in view of the enormous consumption of drugs by the population and the lack of clarity on the phenomenon. This article presents an updated review on the rebound effect of drugs, relating it to the homeopathic healing principle.


Assuntos
Cura em Homeopatia , Homeopatia , Fundamentos da Homeopatia , Homeopatia/história , Lei dos Semelhantes , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Rebote , Efeito Secundário
15.
Homeopatia Méx ; 81(681): 13-40, nov.-dic. 2012.
Artigo em Espanhol | LILACS | ID: lil-677983

RESUMO

El modelo homeopático considera la acción secundaria o la reacción vital del organismo como un método terapéutico y, por lo tanto prescribe tratamientos por el principio de similitud; éste consiste en administrar a los individuas enfermos sustancias que han causado síntomas similares en individuas sanas. La reacción vital homeostática o paradójica de un organismo puede ser explicada científicamente en base al efecto de rebate de los medicamentos modernos, el cual puede causar eventos iatrogénicos fatales posteriores a la suspensión de un tratamiento antipático (un término utilizado en medicina alternativa para el tratamiento paliativo, también conocido como enantiopático). Aunque el efecto de rebate ha sido estudiado por la farmacología moderna, este ha sido poco difundido y discutido entre los profesionales de la salud, quienes en muchas ocasiones han sido privados de información crucial necesaria para el manejo seguro de los medicamentos actuales. En este artículo se presenta una revisión actual sobre el efecto de rebate de los medicamentos modernos que fundamentan el principio homeopático de curación y alerta a los médicos sobre este tipo de efecto adverso que usualmente no se notifica. EI efecto de rebate de los medicamentos modernos paliativos fue señalado por Hahnemann hace más de dos siglas, mencionando que éste puede causar efectos adversos fatales, los cuales pueden ser evidenciados como en el caso del ácido acetilsalicílico, los agentes antiinflamatorios, antidepresivos, broncodilatadores, las estatinas, los inhibidores de la bomba de protones, etc. Aunque el efecto de rebate solamente se presenta en una pequeña fracción de individuas (susceptibles) y puede ser evitado mediante una disminución gradual de los medicamentos antipáticos, este ha de mostrado una importancia epidemiológica significativa como resultado del uso masivo de tales drogas paliativas y la falta de conocimiento a este respecto.


The homeopathic model considers the secondary action or the organism vital reaction of the body as a therapeutic method and therefore prescribes treatments by the principle of similarity, which consists to administer to the sick person substances that have caused similar symptoms in healthy individuals. The vital homeostatic or paradoxical reaction of an organism may be explained scientifically based on the rebound effect of modem drugs, which can cause fatal iatrogenic events after discontinuation of the antipathic treatment (a term used in alternative medicine for palliative, also known as enantiopathic). Although the rebound effect has been studied by modem pharmacology, this was not widely known and discussed among health professionals, who have often been deprived of crucial information necessary for the safe handing of current medications. This article presents a current review on the rebound effect of modem medicines as a fundament of homeopathic healing, and alert doctors about these side effects usually are not notified.The rebound effect of modem palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events, which might be illustrated with the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and lack of knowledge in its regard.


Assuntos
Humanos , Lei dos Semelhantes , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Rebote , Efeito Secundário , Antiácidos , Anticolesterolemiantes , Antidepressivos , Aspirina , Broncodilatadores , Doença Iatrogênica , Inibidores da Agregação de Plaquetas
16.
Homeopatia Méx ; 81(681): 13-40, nov.-dic. 2012.
Artigo em Espanhol | HomeoIndex - Homeopatia | ID: hom-10889

RESUMO

El modelo homeopático considera la acción secundaria o la reacción vital del organismo como un método terapéutico y, por lo tanto prescribe tratamientos por el principio de similitud; éste consiste en administrar a los individuas enfermos sustancias que han causado síntomas similares en individuas sanas. La reacción vital homeostática o paradójica de un organismo puede ser explicada científicamente en base al efecto de rebate de los medicamentos modernos, el cual puede causar eventos iatrogénicos fatales posteriores a la suspensión de un tratamiento antipático (un término utilizado en medicina alternativa para el tratamiento paliativo, también conocido como enantiopático). Aunque el efecto de rebate ha sido estudiado por la farmacología moderna, este ha sido poco difundido y discutido entre los profesionales de la salud, quienes en muchas ocasiones han sido privados de información crucial necesaria para el manejo seguro de los medicamentos actuales. En este artículo se presenta una revisión actual sobre el efecto de rebate de los medicamentos modernos que fundamentan el principio homeopático de curación y alerta a los médicos sobre este tipo de efecto adverso que usualmente no se notifica. EI efecto de rebate de los medicamentos modernos paliativos fue señalado por Hahnemann hace más de dos siglas, mencionando que éste puede causar efectos adversos fatales, los cuales pueden ser evidenciados como en el caso del ácido acetilsalicílico, los agentes antiinflamatorios, antidepresivos, broncodilatadores, las estatinas, los inhibidores de la bomba de protones, etc. Aunque el efecto de rebate solamente se presenta en una pequeña fracción de individuas (susceptibles) y puede ser evitado mediante una disminución gradual de los medicamentos antipáticos, este ha de mostrado una importancia epidemiológica significativa como resultado del uso masivo de tales drogas paliativas y la falta de conocimiento a este respecto. (AU)


The homeopathic model considers the secondary action or the organism vital reaction of the body as a therapeutic method and therefore prescribes treatments by the principle of similarity, which consists to administer to the sick person substances that have caused similar symptoms in healthy individuals. The vital homeostatic or paradoxical reaction of an organism may be explained scientifically based on the rebound effect of modem drugs, which can cause fatal iatrogenic events after discontinuation of the antipathic treatment (a term used in alternative medicine for palliative, also known as enantiopathic). Although the rebound effect has been studied by modem pharmacology, this was not widely known and discussed among health professionals, who have often been deprived of crucial information necessary for the safe handing of current medications. This article presents a current review on the rebound effect of modem medicines as a fundament of homeopathic healing, and alert doctors about these side effects usually are not notified.The rebound effect of modem palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events, which might be illustrated with the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and lack of knowledge in its regard. (AU)


Assuntos
Humanos , Efeito Rebote , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Secundário , Lei dos Semelhantes , Doença Iatrogênica , Inibidores da Agregação de Plaquetas , Aspirina , Broncodilatadores , Antidepressivos , Anticolesterolemiantes , Antiácidos
17.
Med. UIS ; 25(2): 155-162, mayo-ago. 2012. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-675052

RESUMO

Este es el reporte de un caso clínico de una paciente con diagnóstico de Síndrome de Stevens-Johnson inducido por fenitoína, quien ingresó a un hospital universitario de tercer nivel en la ciudad de Bogotá, Colombia. Trece días después del inicio del medicamento mencionado por un diagnóstico de síndrome convulsivo focal, la paciente consulta por la aparición de lesiones máculo papulares en cabeza y tronco acompañadas de úlceras orales y genitales. La presentación y distribución de las lesiones, el compromiso sistémico y la asociación temporal con el consumo de fenitoína, apoyaron el diagnóstico de Síndrome de Stevens-Johnson, el cual fue confirmado por el Servicio de Dermatología. La paciente respondió adecuadamente al tratamiento instaurado siendo dada de alta 10 días después de su ingreso sin complicaciones.


This is a case report of a female patient with a diagnosis of Stevens-Johnson Syndrome induced by Phenytoin. The patient was admitted to a third level hospital. Thirteen days after she started phenytoin use (prescribed for her focal seizure disorder), she presented some maculo-papular lesions in head and thorax, associated with oral and genital ulcers. Distribution and presentation of lesions, the systemic compromise, associated with the temporary use of Phenytoin, supported the diagnosis of SJS. The diagnosis was confirmed by Dermatology. The patient was treated successfully and she was discharged without complications ten days after her admission.


Assuntos
Fenitoína , Efeito Secundário , Síndrome de Stevens-Johnson
18.
Int. j. high dilution res ; 11(39)june 22, 2012.
Artigo em Inglês | LILACS | ID: lil-658514

RESUMO

The homeopathic model applies the secondary action or vital reaction of the organism as a therapeutic method and thus prescribes treatment by similitude, which consists in administering to ill individuals substances that cause similar symptoms in healthy individuals. The vital, homeostatic or paradoxical reaction of the organism might be explained scientifically by means of the rebound effect of modern drugs, which might cause fatal iatrogenic events after discontinuation of antipathic (a term used in alternative medicine for palliative treatment, also known as enantiopathic) treatment. Although the rebound effect is studied by modern pharmacology, it is poorly communicated to and discussed among healthcare professionals, who are thus deprived of information needed for the safe management of modern drugs. This article presents an up-to-date review on the rebound effect of modern drugs that grounds the homeopathic principle of healing and calls the attention of doctors to this type of adverse effect that is usually unnoticed. The rebound effect of modern palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events and is illustrated by the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and the lack of knowledge in its regard.


O modelo homeopático aplica a ação secundária ou reação vital do organismo como método terapêutico. Assim, propõe o tratamento por semelhança, que consiste em administrar aos doentes substâncias que produzem sintomas similares em pessoas sadias. A reação vital, homeostática ou paradoxal do organismo pode ser explicada cientificamente com base no efeito rebote das drogas modernas. Este pode produzir eventos iatrogênicos fatais depois da suspensão do tratamento antipático (ou enantiopático, termo utilizado em medicina alternativa para se referir ao tratamento paliativo). Embora o efeito rebote é abordado pela farmacologia moderna, é pouco difundido e discutido pelos profissionais da saúde que, assim, são privados de informação necessária para o manejo seguro das drogas modernas. Este artigo apresenta uma revisão atualizada do efeito rebote das drogas modernas e que também embasa o princípio homeopático da cura. Apontado por Hahnemann mais de dois séculos atrás, o efeito rebote das drogas paliativas modernas pode causar efeitos adversos fatais, como ilustram os exemplos do ácido salicílico, anti-inflamatórios, broncodilatadores, antidepressivos, estatinas, inibidores da bomba de prótons, etc. Embora o efeito rebote seja expressado por uma pequena parte de indivíduos (suscetíveis) e possa ser evitando através da retirada gradual das drogas antipáticas, atinge importância epidemiológica devido ao uso maciço dessas drogas e do desconhecimento a seu respeito.


Assuntos
Humanos , Doença Iatrogênica , Lei dos Semelhantes , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Secundário
19.
Int. j. high dilution res ; 11(39)June 22, 2012.
Artigo em Inglês | LILACS-Express | HomeoIndex - Homeopatia | ID: hom-10775

RESUMO

The homeopathic model applies the secondary action or vital reaction of the organism as a therapeutic method and thus prescribes treatment by similitude, which consists in administering to ill individuals substances that cause similar symptoms in healthy individuals. The vital, homeostatic or paradoxical reaction of the organism might be explained scientifically by means of the rebound effect of modern drugs, which might cause fatal iatrogenic events after discontinuation of antipathic (a term used in alternative medicine for palliative treatment, also known as enantiopathic) treatment. Although the rebound effect is studied by modern pharmacology, it is poorly communicated to and discussed among healthcare professionals, who are thus deprived of information needed for the safe management of modern drugs. This article presents an up-to-date review on the rebound effect of modern drugs that grounds the homeopathic principle of healing and calls the attention of doctors to this type of adverse effect that is usually unnoticed. The rebound effect of modern palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events and is illustrated by the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and the lack of knowledge in its regard.(AU)


O modelo homeopático aplica a ação secundária ou reação vital do organismo como método terapêutico. Assim, propõe o tratamento por semelhança, que consiste em administrar aos doentes substâncias que produzem sintomas similares em pessoas sadias. A reação vital, homeostática ou paradoxal do organismo pode ser explicada cientificamente com base no efeito rebote das drogas modernas. Este pode produzir eventos iatrogênicos fatais depois da suspensão do tratamento antipático (ou enantiopático, termo utilizado em medicina alternativa para se referir ao tratamento paliativo). Embora o efeito rebote é abordado pela farmacologia moderna, é pouco difundido e discutido pelos profissionais da saúde que, assim, são privados de informação necessária para o manejo seguro das drogas modernas. Este artigo apresenta uma revisão atualizada do efeito rebote das drogas modernas e que também embasa o princípio homeopático da cura. Apontado por Hahnemann mais de dois séculos atrás, o efeito rebote das drogas paliativas modernas pode causar efeitos adversos fatais, como ilustram os exemplos do ácido salicílico, anti-inflamatórios, broncodilatadores, antidepressivos, estatinas, inibidores da bomba de prótons, etc. Embora o efeito rebote seja expressado por uma pequena parte de indivíduos (suscetíveis) e possa ser evitando através da retirada gradual das drogas antipáticas, atinge importância epidemiológica devido ao uso maciço dessas drogas e do desconhecimento a seu respeito.(AU)


Assuntos
Humanos , Lei dos Semelhantes , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Secundário , Doença Iatrogênica , Efeito Rebote
20.
Int. j. high dilution res ; 11(39)june 22, 2012. ilus
Artigo em Inglês | LILACS | ID: lil-682121

RESUMO

The homeopathic model applies the secondary action or vital reaction of the organism as a therapeutic method and thus prescribes treatment by similitude, which consists in administering to ill individuals substances that cause similar symptoms in healthy individuals. The vital, homeostatic or paradoxical reaction of the organism might be explained scientifically by means of the rebound effect of modern drugs, which might cause fatal iatrogenic events after discontinuation of antipathic (a term used in alternative medicine for palliative treatment, also known as enantiopathic) treatment. Although the rebound effect is studied by modern pharmacology, it is poorly communicated to and discussed among healthcare professionals, who are thus deprived of information needed for the safe management of modern drugs. This article presents an up-to-date review on the rebound effect of modern drugs that grounds the homeopathic principle of healing and calls the attention of doctors to this type of adverse effect that is usually unnoticed. The rebound effect of modern palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events and is illustrated by the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and the lack of knowledge in its regard.


O modelo homeopático aplica a ação secundária ou reação vital do organismo como método terapêutico. Assim, propõe o tratamento por semelhança, que consiste em administrar aos doentes substâncias que produzem sintomas similares em pessoas sadias. A reação vital, homeostática ou paradoxal do organismo pode ser explicada cientificamente com base no efeito rebote das drogas modernas. Este pode produzir eventos iatrogênicos fatais depois da suspensão do tratamento antipático (ou enantiopático, termo utilizado em medicina alternativa para se referir ao tratamento paliativo). Embora o efeito rebote é abordado pela farmacologia moderna, é pouco difundido e discutido pelos profissionais da saúde que, assim, são privados de informação necessária para o manejo seguro das drogas modernas. Este artigo apresenta uma revisão atualizada do efeito rebote das drogas modernas e que também embasa o princípio homeopático da cura. Apontado por Hahnemann mais de dois séculos atrás, o efeito rebote das drogas paliativas modernas pode causar efeitos adversos fatais, como ilustram os exemplos do ácido salicílico, anti-inflamatórios, broncodilatadores, antidepressivos, estatinas, inibidores da bomba de prótons, etc. Embora o efeito rebote seja expressado por uma pequena parte de indivíduos (suscetíveis) e possa ser evitando através da retirada gradual das drogas antipáticas, atinge importância epidemiológica devido ao uso maciço dessas drogas e do desconhecimento a seu respeito.


Assuntos
Humanos , Ação Farmacodinâmica do Medicamento Homeopático , Doença Iatrogênica , Efeito Secundário , Lei dos Semelhantes
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