Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 3.781
Filtrar
1.
East Mediterr Health J ; 27(8): 790-797, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34486715

RESUMO

Background: The worldwide incidence of congenital anomalies (CAs) is estimated at 3-7%, but actual numbers vary widely among countries. Birth defects are the most common causes of infantile mortality, accounting for ~25% of all neonatal deaths. Aims: To determine the prevalence of congenital anomalies in neonates in Fayoum Governorate; to classify malformations; and to clarify the association between congenital anomalies and possible risk factors. Methods: A cross-sectional study was conducted on 1000 infants in the neonatal intensive care unit and outpatient clinics of Fayoum University Hospital and Fayoum General Hospital during August 2017 to April 2018. Detailed history, clinical examination and relevant investigations were performed. Results: The prevalence of CAs was 7.4%. Major malformations accounted for 78.4% and minor malformations 21.6%. The most common CAs involved the cardiovascular system (32.4%), followed by musculoskeletal anomalies (18.9%), chromosomal anomalies (10.8%), anomalies of the central nervous system (9.5%), gastrointestinal tract (6.8%), genital system (5.4%), eyes, head and neck (5.4%), respiratory system (4.1%), multisystems (2 or more) (4.1%), and renal and urinary systems (2.7%). 82.4% of cases were from rural areas, 62.1% were male, 36.5% were female and 1.4% were ambiguous. 85.1% of neonates with malformations were full term. Conclusion: Cardiovascular, musculoskeletal and chromosomal anomalies were the most common CAs in our study. Positive consanguinity, poor attendance at antenatal clinics, rural residence and multiparty were the most common risk factors associated with CAs.


Assuntos
Anormalidades Congênitas , Anormalidades Congênitas/epidemiologia , Consanguinidade , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Gravidez , Prevalência , Fatores de Risco
2.
Front Public Health ; 9: 696082, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34485226

RESUMO

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected countries across the world. While the zoonotic aspects of SARS-CoV-2 are still under investigation, bats and pangolins are currently cited as the animal origin of the virus. Several types of vaccines against COVID-19 have been developed and are being used in vaccination drives across the world. A number of countries are experiencing second and third waves of the pandemic, which have claimed nearly four million lives out of the 180 million people infected globally as of June 2021. The emerging SARS-CoV-2 variants and mutants are posing high public health concerns owing to their rapid transmissibility, higher severity, and in some cases, ability to infect vaccinated people (vaccine breakthrough). Here in this mini-review, we specifically looked at the efforts and actions of the Egyptian government to slow down and control the spread of COVID-19. We also review the COVID-19 statistics in Egypt and the possible reasons behind the low prevalence and high case fatality rate (CFR%), comparing Egypt COVID-19 statistics with China (the epicenter of COVID-19 pandemic) and the USA, Brazil, India, Italy, and France (the first countries in which the numbers of patients infected with COVID-19). Additionally, we have summarized the SARS-CoV-2 variants, vaccines used in Egypt, and the use of medicinal plants as preventive and curative options.


Assuntos
COVID-19 , Pandemias , Animais , Vacinas contra COVID-19 , Egito/epidemiologia , Humanos , SARS-CoV-2
3.
Afr J Prim Health Care Fam Med ; 13(1): e1-e9, 2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34476974

RESUMO

BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a female psychiatric disorder affecting the behaviour, cognitive abilities, mental health status and academic performance of female students. It includes: mood symptoms, behaviour symptoms and physical symptoms. AIM: To assess phenomenology, measure the prevalence of PMDD among university students and assess the relationship between PMDD and socio-demographic and personality characteristics. SETTING: This study was conducted at Zagazig University, Sharqia Governorate, Egypt. METHODS: A cross-sectional study was conducted from September 2020 to December 2020. It included 755 university students. They filled several questionnaires covering Diagnostic and Statistical Manual of Disorders (DSM-5) criteria to diagnose PMDD, socio-demographic, menstrual factors, physical activity and personality traits. RESULTS: Premenstrual dysphoric disorder was found in 159 out of 755 students (21.1%). Overall, the most frequently reported premenstrual symptoms were overeating/food cravings (84.2%), fatigue/lack of energy (83.6%), depressed mood/hopelessness (82.0%) and hypersomnia (78.9%). Binary logistic regression model revealed that significantly related PMDD risk factors include: being a medical student, having a duration of menstrual bleeding ≥ 7 days, the average length of one cycle ˂ 28 days, high menstrual blood loss, presence of dysmenorrhea and positive family history of premenstrual syndrome (sister/mother). Regarding personality traits, low extroversion and agreeableness, and high neuroticism were also significant PMDD risk factors. CONCLUSION: Prevalence of PMDD was high among university students, especially medical students, and it can have a detrimental effect on both academic life and educational accomplishments, quality of life and daily living activities.


Assuntos
Transtorno Disfórico Pré-Menstrual , Estudantes de Medicina , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Personalidade , Transtorno Disfórico Pré-Menstrual/epidemiologia , Prevalência , Qualidade de Vida , Universidades
4.
J Trop Pediatr ; 67(3)2021 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-34363077

RESUMO

BACKGROUND: Most studies on gastroenteritis have focused on viral and bacterial infections, while gastroenteritis where intestinal protozoan parasites may have played a role has not been well studied. This study was therefore, designed to assess the frequency and several potential risk factors for Cryptosporidium infection among children suffering from acute gastroenteritis and presented to a tertiary hospital in Cairo, Egypt. Effectiveness of modified Ziehl-Neelsen (MZN) and nested polymerase chain reaction (nPCR) for Cryptosporidium detection were evaluated as well. METHODS: A cross-sectional study was performed during the period from July 2018 to December 2018, where 100 human diarrheic stool samples were collected from children aged 3 months up to 12 years old presented to Ain Shams University Pediatrics Hospital, Cairo, Egypt with acute gastroenteritis. Demographic and clinical data were obtained from the participants. Initial parasite screening was done using the MZN staining method, and microscopically examined for Cryptosporidium infection, while genotyping was based on molecular diagnostic assays using nPCR and sequencing for selected samples. RESULTS: The overall frequency of Cryptosporidium infection was 5% using light microscopy, while 19% of samples were positive by nPCR. Cryptosporidium hominis was the only detected genotype. Clinical picture among cases were not significant in comparison to patients with other causes of gastroenteritis. CONCLUSION: Cryptosporidium infection is more common below 5 years of age; however, clinical data are not enough for suspicion of infection. Nucleic acid-based methods are more sensitive and specific despite the high cost in developing countries. However, real estimation of Cryptosporidium disease burden is of an outmost importance to achieve prevention and detection of the Cryptosporidium species genetic diversity. Lay summaryCryptosporidium is a protozoan, which causes gastroenteritis in humans. It is most common below 5 years of age; however, diarrhea and vomiting characteristics are not different from other causes of gastroenteritis. General diagnostic methods are inadequate for detection of these infections. Nested polymerase chain reaction (nPCR) and sequencing are accurate methods for pathogen detection and species verification. Our study included 100 Egyptian children with acute gastroenteritis. The overall frequency of Cryptosporidium infection was 5% using light microscopy, while 19% of samples were positive by nPCR. The clinical picture of the children presenting with this disease was not significantly different from those presenting with gastroenteritis due to other causes. This emphasizes the importance of proper diagnosis to know the true burden of the disease.


Assuntos
Criptosporidiose , Cryptosporidium , Gastroenterite , Criança , Técnicas de Laboratório Clínico , Estudos Transversais , Criptosporidiose/diagnóstico , Criptosporidiose/epidemiologia , Cryptosporidium/genética , Diarreia , Egito/epidemiologia , Fezes , Gastroenterite/diagnóstico , Gastroenterite/epidemiologia , Humanos , Centros de Atenção Terciária
5.
Medicine (Baltimore) ; 100(29): e26661, 2021 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-34398026

RESUMO

ABSTRACT: Vitamin D deficiency is a worldwide public health problem. Low vitamin D and its consequences among children and adolescents could be considered as one of the most important health-related problems. This study aimed to estimate the prevalence of vitamin D deficiency in healthy Egyptian adolescents and investigate factors associated with vitamin D status.A cross-sectional study was conducted on 572 school children (270 males and 302 females) aged 14 to 18 years, who were randomly selected from high schools in one governorate in Egypt. Data were collected through a self-administered questionnaire. Vitamin D level, serum calcium, phosphorus, alkaline phosphates were measured.Vitamin D deficiency was almost present in all the studied Egyptian healthy adolescents (99%), 94.8% had vitamin D deficiency and 4.2% had vitamin D insufficiency. Girls had a higher prevalence of vitamin D deficiency than boys. There was a significant association between lack of physical activity, sun exposure, and vitamin D deficiency.Vitamin D deficiency and insufficiency are highly prevalent. In sunny countries, the special pattern of conservative clothing and the lack of outdoor physical activity might be the underlying factors for the high prevalence in females. Vitamin D supplementation seems to be mandatory to halt the problem.


Assuntos
Deficiência de Vitamina D/epidemiologia , Adolescente , Serviços de Saúde do Adolescente , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Fatores de Risco , Estudantes , Inquéritos e Questionários , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/etiologia
6.
Viruses ; 13(7)2021 07 07.
Artigo em Inglês | MEDLINE | ID: mdl-34372520

RESUMO

The 2019 novel coronavirus (COVID-19) pandemic has placed a significant strain on hepatitis programs and interventions (screening, diagnosis, and treatment) at a critical moment in the context of hepatitis C virus (HCV) elimination. We sought to quantify changes in Direct Acting Antiviral (DAA) utilization among different countries during the pandemic. We conducted a cross-sectional time series analysis between 1 September 2018 and 31 August 2020, using the IQVIA MIDAS database, which contains DAA purchase data for 54 countries. We examined the percent change in DAA units dispensed (e.g., pills and capsules) from March to August 2019 to the same period of time in 2020 across the 54 countries. Interrupted time-series analysis was used to examine the impact of COVID-19 on monthly rates of DAA utilization across each of the major developed economies (G7 nations). Overall, 46 of 54 (85%) jurisdictions experienced a decline in DAA utilization during the pandemic, with an average of -43% (range: -1% in Finland to -93% in Brazil). All high HCV prevalence (HCV prevalence > 2%) countries in the database experienced a decline in utilization, average -49% (range: -17% in Kazakhstan to -90% in Egypt). Across the G7 nations, we also observed a decreased trend in DAA utilization during the early months of the pandemic, with significant declines (p < 0.01) for Canada, Germany, the United Kingdom, and the United States of America. The global response to COVID-19 led to a large decrease in DAA utilization globally. Deliberate efforts to counteract the impact of COVID-19 on treatment delivery are needed to support the goal of HCV elimination.


Assuntos
Antivirais/administração & dosagem , COVID-19/tratamento farmacológico , Antivirais/normas , Brasil/epidemiologia , COVID-19/epidemiologia , Canadá/epidemiologia , Estudos Transversais , Egito/epidemiologia , Finlândia/epidemiologia , Alemanha/epidemiologia , Hepacivirus/isolamento & purificação , Hepatite C , Hepatite C Crônica/tratamento farmacológico , Hepatite C Crônica/epidemiologia , Humanos , Cazaquistão/epidemiologia , Pandemias , Prevalência , SARS-CoV-2/isolamento & purificação , Reino Unido/epidemiologia , Estados Unidos
7.
Int J Infect Dis ; 109: 223-229, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34271200

RESUMO

OBJECTIVES: Current diagnostic tests for tuberculosis (TB) in children living in low-endemic countries are limited by low specificity and the inability of the current tests to differentiate between active TB and latent TB infection (LTBI). This study aimed to evaluate the blood IP-10 mRNA expression level to detect LTBI in Egyptian pediatric household contacts (PHC). METHODS: TB-specific IP-10 and IFN-γ mRNA levels were assessed by real-time quantitative PCR (RT-qPCR) in 72 Egyptian PHC of active pulmonary TB cases. All study participants were also assessed by Tuberculin Skin Test (TST) and Quantiferon gold in tube (QFN-GIT) assay. RESULTS: IP-10 and IFN-γ mRNA expression levels were significantly higher in PHC with active TB or LTBI than TB negative (p < 0.0001). The level of IP-10 mRNA expression was significantly higher in PHC with active TB than LTBI (p = 0.0008). In contrast, there was no significant differences in the IFN-γ mRNA expression between PHC with active TB compared to LTBI (p = 0.49). The sensitivity and specificity of the IP-10 RT-qPCR were 94.2% and 95.2%, respectively, in PHC with active TB compared to 85.7% and 81.8% in PHC with LTBI. The negative and positive predictive values and accuracy of IP-10 RT-qPCR for distinguishing active TB from LTBI were 85.2%, 58.3%, and 72.6% respectively. CONCLUSION: Blood IP-10 mRNA expression level may be a potential diagnostic marker to help distinguish active TB from LTBI in PHC.


Assuntos
Tuberculose Latente , Criança , Egito/epidemiologia , Humanos , Interferon gama/genética , Testes de Liberação de Interferon-gama , Tuberculose Latente/diagnóstico , RNA Mensageiro/genética , Teste Tuberculínico
8.
J Stroke Cerebrovasc Dis ; 30(9): 105956, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34217070

RESUMO

BACKGROUND: Leukoaraiosis (LA) is a finding in the elderly, that might be asymptomatic or can impact their motor and cognitive functions. We studied the presence of LA in the MRI of patients with AIS and its impact on functional outcome at 3 months. METHODS: 500 consecutive patients diagnosed as AIS were enrolled. Medical history included pre-medication by antiplatelets or statins, and vascular risk factors were reported by history and laboratory investigations. Severity of stroke was assessed by NIHSS and stroke outcome was evaluated on discharge and at 3 months by modified Rankin scale (mRS). LA was diagnosed by MRI-FLAIR sequence and delineated from acute infarction by diffusion-weighted image. And accordingly, patients were divided into group A (absent LA) and group B (present LA). RESULTS: 460 patients completed the study, with 53% of patients on antiplatelet therapy and 11.7% on statins prior to stroke. The percentage of patients with LA was significantly more than those without LA. Patients with LA showed a significantly higher age, more frequent and longer duration of diabetes and hypertension, ischemic heart disease, previous stroke/TIA and antiplatelet intake. Microbleeds were more and mRS was worse in LA group. CONCLUSION: The presence of LA in the background MRI of AIS patients is accompanied by the presence of more risk factors, and unfavorable outcome. Pre-medication with antiplatelets did not prevent the incidence of a new stroke especially in LA group. This might necessitate the identification of some medication for secondary prevention in patients with small vessel disease.


Assuntos
Imagem de Difusão por Ressonância Magnética , Avaliação da Deficiência , AVC Isquêmico/diagnóstico , Leucoaraiose/diagnóstico por imagem , Idoso , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Incidência , Hemorragias Intracranianas/etiologia , AVC Isquêmico/epidemiologia , AVC Isquêmico/fisiopatologia , AVC Isquêmico/terapia , Leucoaraiose/epidemiologia , Leucoaraiose/fisiopatologia , Leucoaraiose/terapia , Masculino , Pessoa de Meia-Idade , Inibidores da Agregação Plaquetária/uso terapêutico , Valor Preditivo dos Testes , Prognóstico , Recidiva , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença
9.
Andrologia ; 53(9): e14172, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34197002

RESUMO

Vitamin D deficiency has been linked with different health problems including male infertility. Its function is mediated by the vitamin D receptor, which acts as a transcription factor. Epigenetic mechanisms such as DNA methylation may affect the vitamin D receptor gene and result in gene silencing. The present study aimed to assess serum vitamin D level and seminal methylation of vitamin D receptor gene in idiopathic male infertility. Blood and semen samples were collected from 60 men with idiopathic infertility and 40 healthy fertile men. Vitamin D levels were detected using enzyme-linked fluorescent assay technique and methylation status was assessed by methylation-specific PCR. Results revealed that serum levels of 25OHD were significantly lower in patients compared to controls. Positive correlation was found between serum level of 25OHD and sperm concentration in patients group and progressive motility in total studied group. Methylation of vitamin D receptor gene was significantly higher in patients compared to control group. Negative correlation was found between methylation of vitamin D receptor gene and both sperm concentration and progressive motility in total studied group. Results of the present study suggest that vitamin D deficiency and vitamin D receptor gene methylation may be involved in aetiopathogenesis of idiopathic male infertility.


Assuntos
Infertilidade Masculina , Receptores de Calcitriol/genética , Vitamina D/sangue , Metilação de DNA , Egito/epidemiologia , Humanos , Infertilidade Masculina/genética , Infertilidade Masculina/metabolismo , Masculino , Receptores de Calcitriol/metabolismo , Sêmen , Motilidade Espermática , Espermatozoides/metabolismo
10.
Curr Microbiol ; 78(9): 3516-3525, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34283284

RESUMO

Urinary tract infection (UTI) is regarded one of the most frequent bacterial infections in women. Accordingly, the aim of the current study was to determine the prevalence of extended-spectrum beta-lactamase (ESBL), as well as the degree of antimicrobial resistance among premenopausal (n = 44) and postmenopausal (n = 49) women suffering from uncomplicated UTI. Urinary samples (n = 93) collected from women with UTI were tested for their antimicrobial sensitivity and assessed for ESBL production by both phenotypic and genotypic methods. Phenotypically, the presence of ESBL was observed in 64 isolates, while polymerase chain reaction detected ESBL-encoding genes in 57 isolates. The CTX-M gene was the most predominant (51.6%), followed by TEM (46.2%), and the SHV gene (17.2%). Surprisingly, all ESBL-producing Escherichia coli isolates were multidrug-resistant (MDR). To the best of our knowledge, this is the first study conducted in Egypt showing significant correlation between ESBL production, multidrug resistance and menopausal state in women. The results demonstrate alarming signal for the dissemination of ESBL genes among uropathogenic E. coli that are MDR in Egypt.


Assuntos
Infecções por Escherichia coli , Escherichia coli Uropatogênica , Egito/epidemiologia , Infecções por Escherichia coli/epidemiologia , Feminino , Humanos , Pós-Menopausa , Escherichia coli Uropatogênica/genética , beta-Lactamases/genética
11.
J Environ Public Health ; 2021: 6662476, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34239576

RESUMO

Objectives: This study evaluated the clinical manifestation of COVID-19 and adverse outcomes in patients with comorbidities (outcome: death). Methods: A comparative follow-up investigation involving 148 confirmed cases of COVID-19 was performed for a month (between April and May 2020) at Qaha Hospital to describe the clinical characteristics and outcomes resulting from comorbidities. Participants were divided into two clusters based on the presence of comorbidities. Group I comprised cases with comorbidities, and Group II included subjects without comorbidity. Survival distributions were outlined for the group with comorbidities after the follow-up period. Results: Fever (74.3%), headache (78.4%), cough (78.4%), sore throat (78.4%), fatigue (78.4%), and shortness of breath (86.5%) were the most prevalent symptoms observed in COVID-19 patients with comorbidities. Such patients also suffered from acute respiratory distress syndrome (37.8%) and pneumonia three times more than patients without comorbidities. The survival distributions were statistically significant (chi-square = 26.06, p ≤ 0.001). Conclusion: Multiple comorbidities in COVID-19 patients are linked to severe clinical symptoms, disease complications, and critical disease progression. The presence of one or more comorbidities worsened the survival rate of patients.


Assuntos
COVID-19/epidemiologia , COVID-19/mortalidade , Comorbidade , Pneumonia/epidemiologia , Pneumonia/mortalidade , Síndrome do Desconforto Respiratório/epidemiologia , Síndrome do Desconforto Respiratório/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Causas de Morte , Egito/epidemiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade , SARS-CoV-2 , Adulto Jovem
12.
Artigo em Inglês | MEDLINE | ID: mdl-34207772

RESUMO

In developing countries such as Egypt, the risk of blood-borne diseases such as human immunodeficiency virus, hepatitis B virus, and hepatitis C virus is high for healthcare workers. To evaluate infection control knowledge, attitudes and practices, as well as the associated risk of percutaneous infection among dental students, a cross-sectional study was conducted in four Egyptian public dental schools in 2016. A total of 1776 students received an anonymous questionnaire on infection control knowledge, attitudes, and practices and the occurrence of needle and sharps injuries; 1067 (60.1%) completed the questionnaire. Third- (pre-clinical), fourth- (junior-clinical), and fifth-year (senior-clinical) students comprised 44.2%, 15.6%, and 40.2%, respectively. Although the majority of the students reported good attitudes and practices for infection control, knowledge scores were generally low. Female students scored higher on self-protection and sterilization practices than did male students, and the fourth-year students showed significantly higher scores for infection control practice than did the fifth-year students. In multivariate analysis, higher scores for all infection control practices were associated with higher scores for attitudes towards infection control and fewer (1-3) needle injury experiences. Although an alarming proportion had experienced needle or sharps injuries during clinical training, around 30% of the students had not received a complete hepatitis B vaccination. Future infection control education should introduce refresher training before graduation that focuses on injury prevention and post-exposure protocols. Additionally, introducing safer products and clinical procedures is highly recommended to minimize the risk of injuries during clinical practice for dental students in Egypt.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Ferimentos Penetrantes Produzidos por Agulha , Estudos Transversais , Egito/epidemiologia , Feminino , Humanos , Controle de Infecções , Masculino , Faculdades de Odontologia , Inquéritos e Questionários
13.
Food Environ Virol ; 13(3): 322-328, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34086254

RESUMO

The objective of this study was to investigate human coronavirus NL63 (HCoV-NL63) prevalence among the other respiratory viruses such as parainfluenza, respiratory syncytial virus, and non-enteric adenoviruses in clinical specimens of Egyptian children and raw sewage samples. One hundred clinical specimens were collected from Egyptian children suffering from upper and lower respiratory viral infections in the years 2005-2006 to detect HCoV-NL63 genome using RT-PCR. All the specimens were negative for the virus. Also, a complete absence of HCoV-NL63 genome was observed in the twenty-four raw sewage samples collected from two wastewater treatment plants within Greater Cairo from February 2006 to January 2007. Using nested RT-PCR, parainfluenza virus type 1, respiratory syncytial virus type A, adenovirus type 4, and adenovirus type 7 were detected in 3%, 2%, 5%, and 2% of the clinical specimens, respectively. Of these viruses, only adenovirus type 4 was detected in 1/24 (4.17%) of the raw sewage samples, while a complete absence of the other investigated respiratory viruses was observed in the raw sewage samples. The low percentage of positivity in the clinical specimens, the concentration method of the raw sewage samples, and the indirect routes of transmission may be the reasons for the absence of respiratory viruses in raw sewage samples. On the other hand, enteric adenoviruses were detected in 21/24 (87.5%) of the raw sewage samples with a higher prevalence of adenovirus type 41 than adenovirus type 40. A direct route of transmission of enteric viruses to raw sewage may be the reason for the high positivity percentage of enteric adenoviruses in raw sewage samples.


Assuntos
Adenoviridae , Infecções por Coronavirus/virologia , Coronavirus Humano NL63 , Vírus da Parainfluenza 1 Humana , Vírus Sincicial Respiratório Humano , Infecções Respiratórias/virologia , Esgotos/virologia , Infecções por Adenoviridae/virologia , Pré-Escolar , Cidades , Egito/epidemiologia , Humanos , Lactente , Reação em Cadeia da Polimerase , Infecções por Vírus Respiratório Sincicial/virologia , Infecções por Respirovirus/virologia , Manejo de Espécimes , Vírus
14.
Diabetes Metab Syndr ; 15(4): 102153, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34186355

RESUMO

BACKGROUND AND AIMS: The primary purpose of this study is to examine the psychometric qualities of the Fear of COVID-19 Scale (FCV-19S) in a sample of Egyptian college students. The researchers also aim at exploring the construct validity further through examining the relationship between FCV-19S, wellbeing and life satisfaction in Egyptian universities context. The current study aims to evaluate the psychometric properties of the Arabic version of the Fear of COVID-19 scale among Egyptian population. METHODS: The FCV-19S is translated and validated in Egyptian context. The forward backward translation method is used to translate the English version of the survey into Arabic. The sample is comprised of 1832 Egyptian participants, who have conducted an online survey based on the Arabic versions of FCV-19S. RESULTS: The Cronbach α value for the Egyptian FCV-19S is 0.87, indicating a good internal reliability. The results of the confirmatory factor analysis show that the unidimensional factor structure of the FCV-19S has fitted well with the data. The FCV-19S is significantly correlated with the seven-item survey. Moreover, the results show a significant negative relationship between Fear of COVID-19 and both wellbeing and life satisfaction (r = -0.42, p < 0.001; r = -0.24, p < 0.01.), respectively. CONCLUSION: The study supports the one factor model of FCV-19S scale in Egyptian context. The Arabic scale version in the Egyptian context shows excellent reliability and validity. This ensures a good measure that can be accepted for both academia and practitioners for analyzing ill-effects of pandemic impacts and, thereby, reducing them.


Assuntos
Ansiedade/epidemiologia , COVID-19/psicologia , Depressão/epidemiologia , Medo/psicologia , Psicometria/métodos , SARS-CoV-2/isolamento & purificação , Estudantes/psicologia , Adolescente , Adulto , Ansiedade/psicologia , COVID-19/transmissão , COVID-19/virologia , Estudos Transversais , Depressão/psicologia , Egito/epidemiologia , Feminino , Humanos , Masculino , Psicometria/estatística & dados numéricos , Reprodutibilidade dos Testes , Inquéritos e Questionários , Universidades , Adulto Jovem
15.
Sociol Health Illn ; 43(7): 1565-1580, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34133030

RESUMO

Analysing data from a nationally representative sample of 3442 interviews conducted in Egypt in 2020, this study examines the influence of four sets of factors in predicting compliance with the advice of healthcare professionals to combat the spread of COVID-19: demographics, knowledge and values, fear of the disease and denial, and the pandemic as a foreign invasion. The findings show that a higher likelihood of compliance is linked to socioeconomic status, awareness of the pandemic, reliance on a plurality of information sources, adherence to liberal values, and fear of the disease, but being male, young, employed, religious, fatalistic, and in denial of the severity of the pandemic lower this likelihood - all consistent with the results reported in the literature. In addition, this study highlights the link between compliance and such attributes of nationalism as national identity, national pride, the perception of the pandemic as a national event, and the willingness to sacrifice one's human right to combat the spread of the disease. Drawing on these factors, this paper suggests building societal consensus around the theme of national unity against the microparasitic invasion is the key to an effective strategy to combat the spread of the virus.


Assuntos
COVID-19 , Pandemias , Egito/epidemiologia , Pessoal de Saúde , Humanos , Masculino , Pandemias/prevenção & controle , SARS-CoV-2
16.
Curr Diabetes Rev ; 17(8): 8-15, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34102979

RESUMO

BACKGROUND: Type 2 diabetes is a part of metabolic syndrome associated with a higher risk of vascular complications. Diabetes is characterized by changes in platelet morphology, function, and platelet hyperactivity so, it's considered a prothrombotic condition. Morbidity and mortality in people with type 2 diabetes-related to micro and macrovascular complications. Novel biomarkers are needed to identify and treat people at higher risk. OBJECTIVE: The main objective of this controlled cross-sectional study was to evaluate Platelet volume indices (PVI) in subjects with type 2 diabetes with and without complications in comparison to subjects without diabetes. METHODS: Hundred and thirty-five subjects aged from 35 to 60 years were subdivided into 3 groups. Group A includes 55 subjects with type 2 diabetes with complications. Group B includes 45 subjects with type 2 diabetes without complications. Group C includes 35 normal healthy subjects. Detailed clinical history was taken. Also, PVI, fasting blood glucose (FBG), hemoglobin A1c, and creatinine were obtained. RESULTS: Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet large cell ratio (P-LCR) were significantly higher among subjects with retinopathy, nephropathy, and neuropathy than other subjects with diabetes who didn't develop complications (P<0.001). At cutoff value > 11.9 fL, MPV have diagnostic sensitivity 80% and specificity 97.8%. Whereas PDW >16.9fL has a sensitivity of 74.5% and specificity of 100% for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy). CONCLUSION: MPV and PDW may be considered as possible biomarkers for the early detection of diabetic microvascular complications.


Assuntos
Diabetes Mellitus Tipo 2 , Volume Plaquetário Médio , Estudos Transversais , Diabetes Mellitus Tipo 2/complicações , Egito/epidemiologia , Humanos , Contagem de Plaquetas
17.
BMC Public Health ; 21(1): 1188, 2021 06 22.
Artigo em Inglês | MEDLINE | ID: mdl-34158006

RESUMO

BACKGROUND: Self-testing for hepatitis C virus antibodies (HCVST) may be an additional strategy to expand access to hepatitis C virus (HCV) testing and support elimination efforts. We conducted a study to assess the usability and acceptability of HCVST among the general population in a semi-rural, high-HCV prevalence region in Egypt. METHODS: An observational study was conducted in two hospitals in the Nile Delta region. A trained provider gave an in-person demonstration on how to use the oral fluid HCVST followed by observation of the participant performing the test. Usability was assessed by observing errors made and difficulties faced by participants. Acceptability of HCV self-testing was assessed using an interviewer-administered semi-structured questionnaire. RESULTS: Of 116 participants enrolled, 17 (14.6%) had received no formal education. The majority (72%) of participants completed all testing steps without any assistance and interpreted the test results correctly. Agreement between participant-reported HCVST results and interpretation by a trained user was 86%, with a Cohen's kappa of 0.6. Agreement between participant-reported HCVST results and provider-administered oral fluid HCV rapid test results was 97.2%, with a Cohen's kappa of 0.75. The majority of participants rated the HCVST process as easy (53%) or very easy (44%), and 96% indicated they would be willing to use HCVST again and recommend it to their family and friends. CONCLUSION: Our study demonstrates the high usability and acceptability of oral fluid HCVST in a general population. Further studies are needed to establish the optimal positioning of self-testing alongside facility-based testing to expand access to HCV diagnosis in both general and high-risk populations.


Assuntos
Hepacivirus , Hepatite C , Egito/epidemiologia , Hepatite C/diagnóstico , Hepatite C/epidemiologia , Anticorpos Anti-Hepatite C , Humanos , Autoteste
18.
Plast Reconstr Surg ; 148(1): 168e-169e, 2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-34110314

Assuntos
COVID-19/prevenção & controle , Controle de Infecções/organização & administração , Pandemias/prevenção & controle , Centro Cirúrgico Hospitalar/organização & administração , Cirurgia Plástica/organização & administração , COVID-19/diagnóstico , COVID-19/epidemiologia , COVID-19/transmissão , Teste para COVID-19/normas , Teste para COVID-19/estatística & dados numéricos , Teste para COVID-19/tendências , Egito/epidemiologia , Procedimentos Cirúrgicos Eletivos/normas , Procedimentos Cirúrgicos Eletivos/estatística & dados numéricos , Procedimentos Cirúrgicos Eletivos/tendências , Política de Saúde , Humanos , Controle de Infecções/normas , Controle de Infecções/estatística & dados numéricos , Controle de Infecções/tendências , Procedimentos Cirúrgicos Reconstrutivos/normas , Procedimentos Cirúrgicos Reconstrutivos/estatística & dados numéricos , Procedimentos Cirúrgicos Reconstrutivos/tendências , SARS-CoV-2/isolamento & purificação , Centro Cirúrgico Hospitalar/normas , Centro Cirúrgico Hospitalar/estatística & dados numéricos , Centro Cirúrgico Hospitalar/tendências , Cirurgia Plástica/normas , Cirurgia Plástica/estatística & dados numéricos , Cirurgia Plástica/tendências , Telemedicina/organização & administração , Telemedicina/normas , Telemedicina/estatística & dados numéricos , Centros de Atenção Terciária/organização & administração , Centros de Atenção Terciária/normas , Centros de Atenção Terciária/estatística & dados numéricos , Centros de Atenção Terciária/tendências , Triagem/organização & administração , Triagem/normas , Triagem/estatística & dados numéricos , Triagem/tendências
19.
J Med Virol ; 93(10): 5833-5838, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34076901

RESUMO

Researchers around the world are working at record speed to find the best ways to treat and prevent coronavirus disease 2019 (COVID-19). This study aimed to evaluate the efficacy of ivermectin for the treatment of hospitalized mild to moderate COVID-19 infected patients. This was a randomized open-label controlled study that included 164 patients with COVID-19. Patients were randomized into two groups where Group 1 (Ivermectin group) included patients who received ivermectin 12 mg once daily for 3 days with standard care and Group 2 (control group) included patients who received standard protocol of treatment alone for 14 days. The main outcomes were mortality, the length of hospital stay, and the need for mechanical ventilation. All patients were followed up for 1 month. Overall, 82 individuals were randomized to receive ivermectin plus standard of care and 82 to receive standard of care alone. Patients in the ivermectin group had a shorter length of hospital stay (8.82 ± 4.94 days) than the control group (10.97 ± 5.28 days), but this was not statistically significant (p = 0.085). Three patients (3.7%) in each group required mechanical ventilation (p = 1.00). The death rate was three patients in the ivermectin group (3.7%) versus four patients (4.9%) in the control group without any significant difference between the two groups (p = 1.00). Although there was no statistically significant difference in any endpoints by ivermectin doses (12 mg/day for 3 days); there was an observed trend to reducing hospital stay in the ivermectin-treated group.


Assuntos
Antivirais/uso terapêutico , COVID-19/tratamento farmacológico , Ivermectina/uso terapêutico , Adulto , Idoso , COVID-19/diagnóstico , COVID-19/mortalidade , Egito/epidemiologia , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Respiração Artificial , SARS-CoV-2/efeitos dos fármacos , Resultado do Tratamento
20.
J Prim Care Community Health ; 12: 21501327211027432, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34166137

RESUMO

OBJECTIVES: This study aimed to evaluate the interleukin-6 (IL-6) levels and its relationship to stress, anxiety, and depressive symptoms among healthcare workers (HCWs) compared to controls during the COVID-19 pandemic. METHODS: A total of 80 HCWs in Suez Canal University Hospital in Ismailia, Egypt, and 80 controls were analyzed during the COVID-19 pandemic. The Depression, Anxiety and Stress Scale (DASS 21) questionnaire was used, and serum IL-6 level was determined in both groups. RESULTS: IL-6 levels were high in 81.2% (65) of HCWs compared to 36% (45) of controls (P < .05). The DASS score was higher in participants with high IL-6 levels (>3 ng/mL) than in those with mild to moderate levels (P < .05). The regression model revealed that the type of work as a healthcare staff, irregular or night shift, and stress were predictors of increased IL-6 levels among the studied sample (P < .05) (odds ratio = 20.30, 2.44, and 2.04, respectively). CONCLUSION: The IL-6 level and DASS score were higher in HCWs compared to those in controls during the COVID-19 pandemic. The type of work as a healthcare staff, stress, and irregular or night shift were predictors of increased IL-6 levels.


Assuntos
COVID-19 , Depressão , Ansiedade/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Egito/epidemiologia , Pessoal de Saúde , Humanos , Pandemias , SARS-CoV-2
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...