Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 5.924
Filtrar
2.
Am J Hum Genet ; 106(3): 412-421, 2020 03 05.
Artigo em Inglês | MEDLINE | ID: mdl-32142645

RESUMO

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% of individuals affected by PFBC have no molecular diagnosis. We report four unrelated families presenting with initial learning difficulties and seizures and later psychiatric symptoms, cerebellar ataxia, extrapyramidal signs, and extensive calcifications on brain imaging. Through a combination of homozygosity mapping and exome sequencing, we mapped this phenotype to chromosome 21q21.3 and identified bi-allelic variants in JAM2. JAM2 encodes for the junctional-adhesion-molecule-2, a key tight-junction protein in blood-brain-barrier permeability. We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblasts, consistent with a loss-of-function mechanism. We show that the human phenotype is replicated in the jam2 complete knockout mouse (jam2 KO). Furthermore, neuropathology of jam2 KO mouse showed prominent vacuolation in the cerebral cortex, thalamus, and cerebellum and particularly widespread vacuolation in the midbrain with reactive astrogliosis and neuronal density reduction. The regions of the human brain affected on neuroimaging are similar to the affected brain areas in the myorg PFBC null mouse. Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the movement of solutes through the paracellular spaces in the neurovascular unit is a key mechanism in CNS calcification.


Assuntos
Idade de Início , Alelos , Encefalopatias/genética , Calcinose/genética , Moléculas de Adesão Celular/genética , Genes Recessivos , Adolescente , Adulto , Animais , Encefalopatias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Criança , Feminino , Humanos , Masculino , Camundongos , Pessoa de Meia-Idade , Linhagem
3.
Nat Rev Neurol ; 16(3): 137-153, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32094487

RESUMO

Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to prominence recently owing to advances in knowledge of their roles in clearance of interstitial fluid and waste from the brain, particularly during sleep, and in the pathogenesis of small vessel disease, Alzheimer disease and other neurodegenerative and inflammatory disorders. Experimental advances have facilitated in vivo studies of perivascular space function in intact rodent models during wakefulness and sleep, and MRI in humans has enabled perivascular space morphology to be related to cognitive function, vascular risk factors, vascular and neurodegenerative brain lesions, sleep patterns and cerebral haemodynamics. Many questions about perivascular spaces remain, but what is now clear is that normal perivascular space function is important for maintaining brain health. Here, we review perivascular space anatomy, physiology and pathology, particularly as seen with MRI in humans, and consider translation from models to humans to highlight knowns, unknowns, controversies and clinical relevance.


Assuntos
Encefalopatias , Sistema Glinfático/anatomia & histologia , Sistema Glinfático/diagnóstico por imagem , Sistema Glinfático/fisiologia , Animais , Encefalopatias/diagnóstico por imagem , Encefalopatias/patologia , Encefalopatias/fisiopatologia , Humanos
4.
Z Gerontol Geriatr ; 53(2): 112-118, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-32020285

RESUMO

The prevalence of insomnia is particularly high in old age. Sleep disturbances and impaired daytime functioning reflected in mood swings and concentration difficulties are often accompanied by other mental disorders such as depression. The objective of this article is to shed light on the role of insomnia in the context of frequent comorbidities in middle and old age. The focus is on the identification of linkage points between insomnia and associated diseases on a neurobiological level; however, possible distinguishing features are also named and deliberations on cognitive behavioral aspects and integrative theories, such as the hyperarousal theory are discussed. In order to provide an outlook for future research opportunities, the UK Biobank is presented as a promising resource of long-term data. Finally, the contents of the preceding deliberations are critically reflected and practical implications for the treatment of older patients with insomnia are derived.


Assuntos
Encefalopatias/diagnóstico por imagem , Cognição/fisiologia , Depressão/epidemiologia , Neuroimagem/métodos , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Envelhecimento , Comorbidade , Depressão/psicologia , Transtorno Depressivo , Humanos , Pessoa de Meia-Idade , Prevalência
5.
PLoS One ; 15(1): e0227355, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31990937

RESUMO

Incomplete hippocampal inversion (IHI), also called hippocampal malrotation, is an atypical presentation of the hippocampus present in about 20% of healthy individuals. Here we conducted the first genome-wide association study (GWAS) in IHI to elucidate the genetic underpinnings that may contribute to the incomplete inversion during brain development. A total of 1381 subjects contributed to the discovery cohort obtained from the IMAGEN database. The incidence rate of IHI was 26.1%. Loci with P<1e-5 were followed up in a validation cohort comprising 161 subjects from the PING study. Summary statistics from the discovery cohort were used to compute IHI heritability as well as genetic correlations with other traits. A locus on 18q11.2 (rs9952569; OR = 1.999; Z = 5.502; P = 3.755e-8) showed a significant association with the presence of IHI. A functional annotation of the locus implicated genes AQP4 and KCTD1. However, neither this locus nor the other 16 suggestive loci reached a significant p-value in the validation cohort. The h2 estimate was 0.54 (sd: 0.30) and was significant (Z = 1.8; P = 0.036). The top three genetic correlations of IHI were with traits representing either intelligence or education attainment and reached nominal P< = 0.013.


Assuntos
Encefalopatias/genética , Predisposição Genética para Doença , Estudo de Associação Genômica Ampla , Hipocampo/fisiopatologia , Adolescente , Aquaporina 4/genética , Encefalopatias/diagnóstico por imagem , Encefalopatias/fisiopatologia , Proteínas Correpressoras/genética , Feminino , Hipocampo/diagnóstico por imagem , Humanos , Masculino , Polimorfismo de Nucleotídeo Único/genética , Lobo Temporal/fisiopatologia
6.
World Neurosurg ; 135: 306-307, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31899396

RESUMO

Cytotoxic lesions of the corpus callosum will be present in a wide range of clinical conditions. The term "cytotoxic lesions of the corpus callosum" reflects our current understanding of the underlying pathophysiology of these lesions and does not necessarily imply confinement to the splenium. Because the symptoms vary and are not specific, the clinical diagnosis can be difficult. Brain magnetic resonance imaging will be of pivotal value in the investigation. We report the case of a patient with obsessive-compulsive disorder who underwent bilateral deep brain stimulation of the nucleus accumbens and developed infection along the surgical path of both electrodes associated with a cytotoxic lesion in the splenium of corpus callosum.


Assuntos
Encefalopatias/diagnóstico por imagem , Corpo Caloso/diagnóstico por imagem , Neuroestimuladores Implantáveis , Implantação de Prótese , Infecções Estafilocócicas/diagnóstico , Infecção da Ferida Cirúrgica/diagnóstico , Adulto , Antibacterianos/uso terapêutico , Encefalopatias/complicações , Claritromicina/uso terapêutico , Estimulação Encefálica Profunda , Imagem de Difusão por Ressonância Magnética , Humanos , Imagem por Ressonância Magnética , Masculino , Transtorno Obsessivo-Compulsivo/terapia , Infecções Estafilocócicas/complicações , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus aureus , Infecção da Ferida Cirúrgica/complicações , Infecção da Ferida Cirúrgica/tratamento farmacológico , Tomografia Computadorizada por Raios X
7.
Am J Forensic Med Pathol ; 41(1): 70-74, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31850919

RESUMO

We present a case of a 22-year-old man who died unexpectedly after a seizure due to a previously undiagnosed calcifying pseudoneoplasm of the neuraxis (CAPNON). Calcifying pseudoneoplasm of the neuraxis is a rare entity, and this is, to our knowledge, the first described case of sudden death due to CAPNON. Sudden death due to undiagnosed central nervous system mass lesions is rare, and most cases are attributable to hemorrhage, hydrocephalus, or increased intracranial pressure due to mass effect. Seizure is a rare cause of sudden death due to central nervous system mass lesions. This case highlights that mass lesions may cause sudden death due to seizure, even without other pathologic evidence of a cause of death, such as hemorrhage or edema. Furthermore, benign, reactive, and low-grade mass lesions may cause sudden death due to seizure. Seizure should remain in the autopsy differential as a cause of death, even where there is no pathologically evident mechanism by which a mass lesion caused death.


Assuntos
Encefalopatias/patologia , Calcinose/patologia , Morte Súbita/etiologia , Encefalopatias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Lobo Frontal/diagnóstico por imagem , Lobo Frontal/patologia , Humanos , Masculino , Convulsões/etiologia , Tomografia Computadorizada por Raios X , Substância Branca/patologia , Adulto Jovem
8.
Maturitas ; 132: 35-39, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31883661

RESUMO

OBJECTIVES: The use of vitamin K antagonists (VKA) is associated with the onset of vascular and soft-tissue calcifications. Whether there are more intracranial calcifications under VKA remains unclear. The objective of this study was to determine whether the regular use of VKA in older adults was associated with an increased burden of intracranial calcifications compared with the use of direct oral anticoagulant (DOA). STUDY DESIGN: Nineteen patients aged 70 years or more using VKA for more than 3 months and 19 controls (matched for age, gender and indication for anticoagulation) using DOA for more than 3 months were consecutively included in this study. MAIN OUTCOMES MEASURES: The burden of intracranial calcifications was graded by an experienced neuroradiologist from 0 (no burden) to 3 (high burden) according to the quantity, size, intensity and confluence of calcifications on computed tomography scan of the brain. Age, gender, frontal assessment battery (FAB) score, hypertension, dyslipidaemia, carotid artery stenosis, kidney failure and indication for anticoagulation were investigated as potential confounders. RESULTS: The 19 patients using VKA (median[IQR], 84years[7]; 10females) exhibited a greater burden of falcian calcifications than the 19 controls using DOA (respectively, 2[1] versus 1[2], P = 0.025). Overall, we found that using VKA was directly associated with the global burden of intracranial calcifications (ß = 1.54, P = 0.049). No correlation was found with calcifications in sites other than the falx cerebri. CONCLUSIONS: The use of VKA was associated with a greater burden of intracranial calcifications compared with the use of DOA, specifically in the falx cerebri. This finding may explain part of the neurocognitive morbidity met with VKA.


Assuntos
Anticoagulantes/efeitos adversos , Encefalopatias/induzido quimicamente , Calcinose/induzido quimicamente , Vitamina K/antagonistas & inibidores , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/administração & dosagem , Encefalopatias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Dura-Máter/diagnóstico por imagem , Feminino , França , Humanos , Masculino , Tomografia Computadorizada por Raios X
9.
Radiol Clin North Am ; 58(1): 167-185, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31731899

RESUMO

A brief introduction is provided of the different imaging modalities encountered in the intensive care unit (ICU). The spectrum of intracranial pathology as well as potential postsurgical complications is reviewed, with a focus on pearls and pitfalls. A brief overview also is provided of imaging of the spine in an ICU patient.


Assuntos
Encefalopatias/diagnóstico por imagem , Imagem por Ressonância Magnética/métodos , Neuroimagem/métodos , Tomografia Computadorizada por Raios X/métodos , Encéfalo/diagnóstico por imagem , Cuidados Críticos/métodos , Humanos , Unidades de Terapia Intensiva
10.
Radiol Clin North Am ; 58(1): 187-197, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31731900

RESUMO

Neuroimaging is an invaluable diagnostic tool for sorting through the vast array of etiologies that underlie altered mental status (AMS). Head computed tomography (CT) without contrast is the primary modality for evaluation of AMS and should be complemented by MR imaging in cases of negative CT but high clinical concern. Studies to maximize brain imaging efficiency and improve the yield of positive scans through the utilization of clinical and laboratory pre-scan diagnostics are ongoing. However, imaging remains the gold standard due to its rapidity with which certain diagnoses can be made or excluded.


Assuntos
Encefalopatias/diagnóstico por imagem , Imagem por Ressonância Magnética/métodos , Neuroimagem/métodos , Tomografia Computadorizada por Raios X/métodos , Encéfalo/diagnóstico por imagem , Humanos
11.
Medicine (Baltimore) ; 98(51): e18075, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31860957

RESUMO

RATIONALE: Dyke-Davidoff-Masson syndrome (DDMS) is a rare syndrome commonly occurring in children and characterized by cerebral hemiatrophy, hypertrophy of the skull, epilepsy, and mental retardation. However, few have been reported in China, especially in teenagers. This case investigated its possible cause and explored a relative effective solution. PATIENT CONCERNS: A 24-year-old female came to department having experienced recurrent seizures for 12 years. DIAGNOSIS: DDMS was diagnosed from its manifestations, biochemistry indexes, and imaging (computed tomography angiography, magnetic resonance venography, and so on). INTERVENTIONS: Several drugs are used to treat the disease, including valproate, carbamazepine, topiramate, and ginkgo biloba extract. OUTCOMES: Under the medicine treatment of magnesium valproate with carbamazepine, the patient experienced partial seizures approximately once per month that lasted 30 to 60 seconds each without any complications observed during a follow-up period of 24 months. CONCLUSION: The imaging and clinical features of DDMS in this teenager were similar to those in classic infantile-onset cases. A potential cause of the disease could be brain trauma, which impaired the middle cerebral artery and reduced cerebral blood supply, leading to epilepsy and hemiatrophy. LESSONS: It was concluded early diagnosis and pharmacotherapy are the keys to preventing intellectual decline in DDMS patients. Moreover, the combination of magnesium valproate and carbamazepine could significantly reduce the frequency and duration of seizures, despite not eliminating them completely.


Assuntos
Encefalopatias/diagnóstico por imagem , Deficiência Intelectual/diagnóstico , Imagem por Ressonância Magnética/métodos , Convulsões/diagnóstico , Convulsões/tratamento farmacológico , Encefalopatias/tratamento farmacológico , Carbamazepina/uso terapêutico , China , Doença Crônica , Feminino , Humanos , Deficiência Intelectual/tratamento farmacológico , Prognóstico , Recidiva , Medição de Risco , Índice de Gravidade de Doença , Síndrome , Tomografia Computadorizada por Raios X/métodos , Ácido Valproico , Adulto Jovem
12.
J Biol Regul Homeost Agents ; 33(6): 1725-1736, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31696693

RESUMO

Magnetic Resonance (MR) is a non-invasive modality of choice for the evaluation of brain morphology, with superior performance as compared to other techniques. However, MR images are typically assessed qualitatively, thus relying on the experience of the involved radiologist. This may lead to errors of interpretation in the presence of subtle alterations and does not exploit the full potential of this technique as a quantitative diagnostic tool. To this end Magnetic Resonance Relaxometry (MRR), which is able to quantitively characterize the tissues under investigation through their relaxation rates, seems extremely promising. Many studies assessed the feasibility of relaxometry as a diagnostic tool in human brain disorders, with the most promising results obtained in the evaluation of neurodegenerative diseases and in the oncologic field. However, despite such extensive literature in human medicine, due to the lack of standardized protocols and the need of high-field MRI scanners, to date few studies have been performed on companion animals. In this work, first we describe relaxometry applications in human neuropathology and their possible extension to companion animals both in the experimental and clinical fields. Then, we present two experiments performed on a typical standard clinical scanner operating at 0.25 T to show that, despite the low field intensity, this technique may be promising even in the clinical setup. We tested the relaxometry protocol in a phantom study and then applied it to a real clinical case study. The results showed that this protocol used on a phantom led to a higher contrast, as compared to the standard approach. Furthermore, when applied to a real case study, this protocol revealed brain lesions undetected by the standard technique which were confirmed by a histopathological examination. These preliminary results are encouraging and support the development of this approach as an advanced diagnostic tool even in a clinical setting where low field MRI scanners are typically employed.


Assuntos
Encefalopatias/diagnóstico por imagem , Encéfalo/diagnóstico por imagem , Imagem por Ressonância Magnética/veterinária , Animais , Encéfalo/patologia , Imagens de Fantasmas
14.
Medicine (Baltimore) ; 98(44): e17638, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689772

RESUMO

INTRODUCTION: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) was shown to have a transient reduction in diffusion. Such changes would be used as an early detection to reduce excessive treatments and promote recovery without sequelae. The current research evaluated the high b-value (b = 3000 s/mm) diffusion-weighted imaging (DWI) assessment in MERS. METHODS: Sixteen pediatric patients showed MERS used DWI (b = 1000 and 3000 s/mm). To record number of lesions, the signal intensities, signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs), contrast ratios (CRs), the apparent diffusion coefficients (ADCs) were measured in the normal parenchyma and lesions. RESULTS: Lesions were more apparent with high b-value. The ADC values and CNR in the lesions and surrounding normal brain parenchyma were relatively low at a high compared to standard b-value DWI (SNR: 144.67 ±â€Š33.03, 85.72 ±â€Š31.50; CNR: 20.82 ±â€Š17.64, 49.62 ±â€Š33.06; for b = 1000 and 3000 s/mm). The CR was significantly higher at a high compared to low b-value DWI (CR: 0.06 ±â€Š0.07 versus 0.40 ±â€Š0.14). CONCLUSION: High b-value DWI could detect more lesions and could obviously improve the detection of lesions in pediatric patients with MERS.


Assuntos
Encefalopatias/diagnóstico , Encefalopatias/patologia , Corpo Caloso/diagnóstico por imagem , Corpo Caloso/patologia , Encefalopatias/diagnóstico por imagem , Criança , China , Imagem de Difusão por Ressonância Magnética , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Masculino , Estudos Retrospectivos , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Razão Sinal-Ruído
16.
Radiol Clin North Am ; 57(6): 1133-1146, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31582040

RESUMO

The clinical and radiologic manifestations of posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome are reviewed. The relationship between these entities is discussed. A hypothesis of a common underlying pathophysiology is proposed and substantiated based on the current medical literature.


Assuntos
Encéfalo/diagnóstico por imagem , Encéfalo/fisiopatologia , Imagem por Ressonância Magnética/métodos , Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Vasoconstrição/fisiologia , Encefalopatias/diagnóstico por imagem , Encefalopatias/fisiopatologia , Humanos , Síndrome
17.
Continuum (Minneap Minn) ; 25(5): 1438-1490, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31584545

RESUMO

PURPOSE OF REVIEW: This article discusses an approach to imaging in patients with neuro-ophthalmologic disorders, with emphasis on the clinical-anatomic localization of lesions affecting afferent and efferent visual function. RECENT FINDINGS: Advances in MRI, CT, ultrasound, and optical coherence tomography have changed how neuro-ophthalmic disorders are diagnosed and followed in the modern clinical era. SUMMARY: The advantages, disadvantages, and indications for various imaging techniques for neuro-ophthalmologic disorders are discussed, with a view to optimizing how these tools can be used to enhance patient care.


Assuntos
Encefalopatias/diagnóstico por imagem , Imagem por Ressonância Magnética , Neuroimagem , Doenças do Nervo Óptico/diagnóstico por imagem , Doenças Orbitárias/diagnóstico por imagem , Tomografia de Coerência Óptica , Tomografia Computadorizada por Raios X , Ultrassonografia , Humanos
19.
Rev. neurol. (Ed. impr.) ; 69(7): 289-292, 1 oct., 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-187083

RESUMO

Introducción: Las calcificaciones intracraneales pueden tener múltiples etiologías, y la distribución y las características que presenten en la neuroimagen pueden orientar hacia unas u otras. Es importante descartar las entidades más frecuentes que cursan con calcificaciones intracraneales, pero no deben olvidarse otras causas genéticas mucho más remotas, como el síndrome de Coats plus. Caso clínico: Lactante exprematura de 34 semanas de edad gestacional, diagnosticada de retinopatía a los 9 meses al presentar estrabismo. A los 2 años de edad se realizó una resonancia magnética por hemiparesia derecha, en la que se observó una imagen sugestiva inicialmente de neoplasia. Al completar el estudio con una tomografía computarizada craneal, se observaron extensas calcificaciones de predominio en los ganglios basales y lesiones quísticas. Tras descartarse las etiologías más frecuentes de calcificaciones intracraneales, se llegó a la asociación de la retinopatía y la clínica neurológica y se confirmó el síndrome de Coats plus mediante estudio genético, que reveló la presencia de dos variantes en heterocigosis no documentadas hasta la fecha en el gen CTC1. Conclusión: El síndrome de Coats plus es una enfermedad autosómica recesiva extraordinariamente infrecuente, provocada por mutaciones en el gen CTC1, que supone la aparición de telangiectasias retinianas, quistes cerebrales, calcificaciones en los núcleos profundos y leucoencefalopatía, además de otras afecciones óseas y gastrointestinales. El tratamiento es sintomático y la enfermedad tiene un mal pronóstico


Introduction: Intracranial calcifications can have a number of different causes, and the distribution and characteristics they present in neuroimaging can orient the specialist towards one or another. It is important to rule out the most frequent entities that are accompanied by intracranial calcifications, but other more remote genetic causes, such as Coats plus syndrome, should not be overlooked. Case report: Ex-premature female Infant with a gestational age of 34 weeks, diagnosed with retinopathy at 9 months after presenting strabismus. At 2 years of age, an MRI scan was performed for right hemiparesis, in which an image suggestive of a neoplasm was initially observed. Upon completion of the study with a cranial computed tomography scan, extensive calcifications were observed predominantly in the basal ganglia along with cystic lesions. After ruling out the most frequent causations of intracranial calcifications, the association between the retinopathy and the neurological features was established, and Coats plus syndrome was confirmed by a genetic study that revealed the presence of two hitherto unreported variants in heterozygosis in the CTC1 gene. Conclusion: Coats plus syndrome is an extraordinarily rare autosomal recessive disease, caused by mutations in the CTC1 gene, which involves the appearance of retinal telangiectasias, brain cysts, calcifications in deep nuclei and leukoencephalopathy, as well as other bone and gastrointestinal conditions. Treatment is symptomatic and the disease has a poor prognosis


Assuntos
Humanos , Feminino , Pré-Escolar , Encefalopatias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Doenças Retinianas/diagnóstico , Doenças Retinianas/genética , Encefalopatias/etiologia , Calcinose/etiologia , Paresia/diagnóstico por imagem , Crânio/diagnóstico por imagem , Doenças Retinianas/fisiopatologia , Crioterapia , Fotocoagulação , Vitrectomia , Eletroencefalografia , Diagnóstico Diferencial
20.
Nat Neurosci ; 22(10): 1617-1623, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31551603

RESUMO

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.


Assuntos
Envelhecimento/genética , Envelhecimento/patologia , Encefalopatias/diagnóstico por imagem , Encefalopatias/genética , Encéfalo/crescimento & desenvolvimento , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Algoritmos , Encéfalo/diagnóstico por imagem , Criança , Pré-Escolar , Feminino , Estudo de Associação Genômica Ampla , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Transtornos Mentais/diagnóstico por imagem , Transtornos Mentais/genética , Pessoa de Meia-Idade , Testes Neuropsicológicos , Esquizofrenia/genética , Esquizofrenia/patologia , Caracteres Sexuais , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA