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1.
Braz. j. oral sci ; 20: e210053, jan.-dez. 2021. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1253163

RESUMO

Aim: The literature has not yet reported investigations about the effect of laser photobiomodulation (LPBM) over the cytotoxicity of drugs for endodontic treatments. Thus, the aim of this study was to evaluate, in vitro, the effect of the association between LPBM and intracanal medications on fibroblasts viability in different exposure times. Methods: Calcium hydroxide (Ca(OH)2) and iodoform (IO) were used pure or associated to LPBM. Eluates of medications were prepared and placed in contact with the cells in three different periods: 24h, 48h and 72h. Laser irradiation (emitting radiation λ 660nm, power density of 10mW, energy density of 3 J/cm²) has been performed in two sessions within a six hour interval, for 12s per well. After each experimental time, the colorimetric assay (MTT) has been performed. Statistical analysis was applied for Mann-Whitney test with 5% α error admitted test. Results: At 24h, the use of LPBM did not increase cell viability while after 72h cell proliferation was stimulated in the group without medications. LPBM application did not increase cell viability in Ca(OH)2 group and IO at any tested time. Ca(OH)2 cytotoxicity at 24h was higher than iodoform, while at 72h not difference was observed. Therefore, after 72 hours was no statistical difference between the IO and Ca(OH)2 groups. Conclusion: LPBM was able to increase cell viability in 72h in the group without medication, although no improvement was observed in the other groups. Thus, LPBM was not able to reduce the cytotoxic effects of the materials on fibroblasts in vitro


Assuntos
Terapia com Luz de Baixa Intensidade , Endodontia , Fibroblastos
2.
Braz. j. oral sci ; 20: e211194, jan.-dez. 2021. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1253930

RESUMO

Aim: The aim of this study was to evaluate the effect of ethanol-conditioned dentin on endodontic sealer penetration into dentinal tubules by confocal laser scanning microscopy (CLSM). Methods: Forty human maxillary anterior teeth were instrumented and divided into four groups (n = 10) according to the drying methods: 1) wet: vacuum only, 2) paper points: vacuum + absorbent paper points, (3) 70% ethanol: 70% ethanol (1 min) + vacuum + absorbent paper points, and (4) 100% ethanol: 100% ethanol (1 min) + vacuum + absorbent paper points. All root canals were filled with resin-based endodontic sealer. Four sections from each third (cervical, middle, and apical) were examined by CLSM. Root canal wall perimeter infiltrated by sealer, maximum depth of sealer penetration, percentage of penetrated area, and fluorescence intensity of rhodamine B were measured. Statistical analysis was performed by analysis of variance and Tukey's tests (α = 0.05). Results: No statistical difference was found when percentage of root canal wall coverage infiltrated by sealer were compared. The groups in which ethanol solutions were used presented greater depth of sealer penetration, higher percentage of penetrated area, and higher fluorescence intensity of rhodamine B (p< 0.05) when compared with the wet and paper point groups. Overall, 100% ethanol produced better results than 70% ethanol, except for rhodamine B intensity (cervical third). In addition, the absorbent paper points drying method behaved better than did vacuum only group, except for rhodamine B intensity (apical third). Conclusion: Ethanol-conditioned dentin improved the penetration of resin-based sealer into dentinal tubules, especially at the concentration of 100%


Assuntos
Humanos , Molhabilidade , Microscopia Confocal , Cimentos de Resina , Dentina , Etanol , Endodontia
3.
Braz. j. oral sci ; 20: e213555, jan.-dez. 2021. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1254634

RESUMO

Aim: This study evaluated, by the application of questionnaires, the impact of the COVID-19 pandemic on the clinical routine and inspection by the competent authorities, on the flow of patients in the office, as well as on possible changes in Endodontic treatment costs and the amounts charged to patients. Methods: This cross-sectional study was conducted from May 2nd, 2020 to May 6th, 2020, using an online questionnaire with a convenience sample. The inclusion criterion was professionals who perform endodontic treatments in daily clinical practice and who professional setting is private practice. The questionnaire brought questions about the impact on costs and the amount charged to the patient. Results: A total of 1042 questionnaires were answered from all the different states of Brazil, by professional who usually perform Endodontic treatment, and who is working in private practice. A total of 1010 (96.9%) respondents affirm it was necessary to modify the protective equipment in endodontic treatment due to pandemic and longer intervals between appointments was cited by 922 (88.5%), economically affecting the dental practice. There was no association between routine changes and economic impacts with gender, professional experience, area of residence or education level. Conclusion: In conclusion, most dental professionals recognized changes in the routine of endodontic treatment during the COVID-19 pandemic. They have a perception of increase in endodontic costs, and reduction in the volume of patients


Assuntos
Humanos , Masculino , Feminino , Inquéritos e Questionários , Coronavirus , Consultórios Odontológicos , Endodontia
4.
J Biol Regul Homeost Agents ; 35(3 Suppl. 1): 87-94, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34289668

RESUMO

The importance of intraoral periapical radiography is crucial as it represents a fundamental mean of evaluation and diagnosis for supporting bone and teeth hard tissues diseases and pathologies. Even though conventional film technology is still widespread, presently there are many digital radiography alternatives. Direct digital systems are devices with an intraoral sensor wired or paired wireless with a computer. These devices do generate an image immediately during exposure and acquisition. The semi direct digital systems instead are based on phosphor image plates. Digital radiography offers many chances to improve our patient's healthcare standards reducing exposition to X-rays and the related stochastic radiation risk. Aim of this study is to compare the quality of images for endodontic purposes comparing three systems: conventional films, direct digital radiography and semidirect digital radiography.


Assuntos
Endodontia , Radiografia Dentária Digital , Humanos , Intensificação de Imagem Radiográfica
7.
BMC Oral Health ; 21(1): 276, 2021 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-34030680

RESUMO

Endodontics is the branch of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues. Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells that play major roles in the defense against pathogens and during tissue injury. However, the efficiency of these mechanisms during dental pulp inflammation (pulpitis) varies due to anatomical and physiological restrictions. Uncontrolled, excessive, or unresolved inflammation can lead to pulp tissue necrosis and subsequent bone infections called apical periodontitis. In most cases, pulpitis treatment consists of total pulp removal. Although this strategy has a good success rate, this treatment has some drawbacks (lack of defense mechanisms, loss of healing capacities, incomplete formation of the root in young patients). In a sizeable number of clinical situations, the decision to perform pulp extirpation and endodontic treatment is justifiable by the lack of therapeutic tools that could otherwise limit the immune/inflammatory process. In the past few decades, many studies have demonstrated that the resolution of acute inflammation is necessary to avoid the development of chronic inflammation and to promote repair or regeneration. This active process is orchestrated by Specialized Pro-resolving lipid Mediators (SPMs), including lipoxins, resolvins, protectins and maresins. Interestingly, SPMs do not have direct anti-inflammatory effects by inhibiting or directly blocking this process but can actively reduce neutrophil infiltration into inflamed tissues, enhance efferocytosis and bacterial phagocytosis by monocytes and macrophages and simultaneously inhibit inflammatory cytokine production. Experimental clinical application of SPMs has shown promising result in a wide range of inflammatory diseases, such as renal fibrosis, cerebral ischemia, marginal periodontitis, and cancer; the potential of SPMs in endodontic therapy has recently been explored. In this review, our objective was to analyze the involvement and potential use of SPMs in endodontic therapies with an emphasis on SPM delivery systems to effectively administer SPMs into the dental pulp space.


Assuntos
Endodontia , Periodontite Periapical , Pulpite , Humanos , Inflamação , Mediadores da Inflamação , Lipídeos , Periodontite Periapical/tratamento farmacológico , Pulpite/tratamento farmacológico
8.
J Endod ; 47(8): 1229-1244, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34058252

RESUMO

INTRODUCTION: Several endodontic access cavity designs have been proposed in the past decade to access the root canal space in a minimally invasive manner. The rationale for this approach was derived from the assumption that preserving more tooth structure during access preparation will improve the tooth's resistance to fracture and its long-term survivability. However, is this assumption valid? Also, can this approach compromise other treatment-related aspects? METHODS: We conducted a literature review using 4 online databases and classified the access cavity designs presented in each article according to our proposed classification. RESULTS: Through the literature search, we identified 49 articles that evaluated the effect of the access cavity design on 11 different treatment parameters. The majority of the studies failed to demonstrate clear benefits of the minimally invasive access designs, whereas others raised concerns regarding the ability to adequately disinfect, fill, and restore teeth with a minimally invasive access cavity design. CONCLUSION: Minimally invasive access cavity designs present more risk than benefit on the outcome of endodontic treatment. Clinicians should reconsider the application of a minimally invasive access cavity for routine endodontics and cautiously apply it in selected cases when the proper armamentarium is available.


Assuntos
Endodontia , Preparo de Canal Radicular , Preparo da Cavidade Dentária , Cavidade Pulpar , Dente Molar , Tratamento do Canal Radicular
9.
Dent Clin North Am ; 65(3): 475-486, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34051926

RESUMO

Endodontics requires radiographic imaging for diagnosis, treatment planning, therapy, and follow-up. Dental radiography allows for the identification of pathologic changes in the periradicular tissues that cannot be visualized by clinical inspection. For the precise execution of endodontic therapy, regular radiographic verification of individual treatment steps is necessary. As a review for clinicians, normal and pathologic findings relevant to Endodontics are presented. Key radiographic imaging techniques, such as the paralleling and bisecting techniques, as well as horizontal and vertical eccentric radiographs, are discussed. The increasing utilization and impact of cone-beam computed tomography providing 3-dimensional volume imaging are reviewed.


Assuntos
Endodontia , Radiologia , Tomografia Computadorizada de Feixe Cônico , Humanos , Planejamento de Assistência ao Paciente , Tratamento do Canal Radicular
10.
Rev. Odontol. Araçatuba (Impr.) ; 42(1): 9-13, jan.-abr. 2021. tab
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1148159

RESUMO

O objetivo do presente estudo foi mensurar o pH externo radicular de dentes bovinos que foram desinfetados em solução de cloramina por 7 dias. Neste estudo foram utilizadas soluções irrigadoras, hipoclorito de sódio 1%, clorexidina 0,12% e hipoclorito de sódio 2,5% associadas ao edta e as medicações intracanais, hidróxido de cálcio, hidróxido de cálcio com PMCC e clorexidina gel 2%. O preparo químico mecânico foi realizado com as limas easy logic e as soluções foram agitadas com ultrassom durante 3 minutos e após os dentes foram imersos em água deionizada em eppendorfs estéreis e mantidos em estufa a 37°C. O pH externo foi analisado utilizando as fitas medidoras de pH no período de 24 horas, 48 horas, 7 dias, 10 dias e 15 dias. A normalidade dos valores obtidos de cada ensaio foi testada através do teste Kolmogorof- Smirnov, e o teste estatístico foi ANOVA de uma via e comparações múltiplas de Tukey. Os resultados mostraram que houve diferença estatística nos valores de pH nos grupos avaliados dentro dos tempos (p< 0,05). Concluiu-se que mesmo com as variações de pH nos períodos avaliados, as medicações e as soluções irrigantes podem ser utilizadas de forma associadas na endodontia, com o intuito de eliminar o maior número de microrganismos dos canais radiculares(AU)


The objective of the present study was to measure the external root pH of bovine teeth that were disinfected in chloramine solution for 7 days. Irrigating solutions, 1% sodium hypochlorite, 0.12% chlorhexidine and 2.5% sodium hypochlorite associated with edta and intracanal medications, calcium hydroxide, calcium hydroxide with PMCC and chlorhexidine gel 2%. The mechanical chemical preparation was performed with the easy logic files and the solutions were shaken with ultrasound for 3 minutes and after the teeth were immersed in deionized water in eppendorfs and kept in an oven at 37 ° C. The external pH was analyzed using the pH measuring tapes in the period of 24 hours, 48 hours, 7 days, 10 days and 15 days. The normal values obtained from each test were tested using the Kolmogorof-Smirnov test, and the statistical test was one-way ANOVA and Tukey's multiple comparisons. The results showed that there was a statistical difference in pH values in the groups evaluated within the times (p< 0.05). It was concluded that even with pH variations in the evaluated periods, medications and irrigating solutions can be used in an associated way in endodontics, in order to eliminate the largest number of microorganisms in the root canals(AU)


Assuntos
Irrigantes do Canal Radicular , Preparo de Canal Radicular , Hipoclorito de Sódio , Hidróxido de Cálcio , Cloraminas , Clorexidina , Análise de Variância , Ácido Edético , Endodontia
11.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 56(4): 311-317, 2021 Apr 09.
Artigo em Chinês | MEDLINE | ID: mdl-33832030

RESUMO

Endodontic diseases, due to the high incidence rate, affect the life quality and aesthetics of patients. As an auxiliary examination method, oral radiographic examination is of great significance for the preoperative diagnosis, treatment and postoperative evaluation of endodontic diseases. The principle of choosing oral radiology methods is to provide accurate and necessary information for diagnosis and treatment while protecting the patients' interests to the greatest extent. The Society of Cariology and Endodontics, Chinese Stomatological Association, based on extensive solicitation of opinions and reference to relevant literature, has set an application guideline after extensive discussions and revisions. This guideline covers the common clinical scenarios of application of radiographic examination in the diagnosis and treatment of endodontic diseases and provides recommendations for radiological methods. Hopefully, the guideline may help the clinicians to solve the important clinical problems and to provide a scientific foundation for the application of radiographic examination in the diagnosis and treatment of endodontic diseases.


Assuntos
Endodontia , Medicina Bucal , Assistência Odontológica , Estética Dentária , Humanos
12.
J Appl Oral Sci ; 29: e20201058, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33886945

RESUMO

Apical periodontitis is an inflammatory disorder of periradicular tissues developed from endodontic infections. Understanding its pathophysiology and the underlying molecular mechanisms is key to the advancement of endodontics. MicroRNAs (miRNAs), a group of evolutionarily conserved small non-coding RNAs, may be phenotypically and functionally associated with the pathogenesis of apical periodontitis. Several studies have focused on the role of miRNAs in the pulp and periradicular biology, and they have demonstrated their essential functions, such as initiating odontogenic differentiation and promoting pro- or anti-inflammatory responses in pulpitis. Up to date, over 2,000 miRNAs have been discovered in humans; however, only few have been reported to associate with apical periodontitis. Therefore, identifying miRNAs involved in diseased apical tissues and conducting functional studies are important in expanding our current knowledge of pulp and periradicular biology and exploring novel therapeutic avenues. In this review, we revisit current models of apical periodontitis and miRNA biogenesis, analyze existing evidence of the involvement of miRNAs in diseased apical tissues, and discuss their diverse functions and potential values. Based on their sheer abundance, prolonged stability in biofluid, and relative ease of sampling, miRNAs may be a useful tool to be developed as diagnostic biomarkers for apical periodontitis. Furthermore, it can be used as therapeutic targets in conjunction with conventional endodontic therapies.


Assuntos
Endodontia , MicroRNAs , Periodontite Periapical , Pulpite , Polpa Dentária , Humanos , MicroRNAs/genética , Periodontite Periapical/genética
14.
J Endod ; 47(6): 895-901, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33798543

RESUMO

INTRODUCTION: Cone-beam computed tomographic (CBCT) imaging is a valuable diagnostic tool for endodontics. Some studies report that CBCT images have limitations in representing the true clinical presentation. This prospective, in vivo study compared limited field of view (LFOV) CBCT measurements with clinical measurements made during endodontic surgery. METHODS: Eighty-seven subjects requiring endodontic surgery and LFOV CBCT acquisition of the surgical site were enrolled. Data collection involved clinicians answering standardized questions during the radiographic and surgical assessment. Intraoperatively, data were collected and photographically documented. Postoperatively, CBCT scans were evaluated by 3 calibrated, board-certified specialists: 2 endodontists and 1 oral and maxillofacial radiologist. The 2 subsets of data were compared through statistical analysis to quantify their relationship. RESULTS: The subjects included 65 maxillary and 29 mandibular teeth from 87 subjects: 25 women and 62 men with an average age of 42 years old. The CBCT evaluators correctly identified the presence or absence of buccal plate fenestrations with 91.0% accuracy (95% confidence interval, 83.1-96.0) with 89.4% sensitivity and 92.9% specificity. The area of fenestrations measured clinically (mean = 19.6 ± 33.4 mm2) was generally larger than the area measured by CBCT imaging (mean across CBCT evaluators = 12.2 ± 19.1 mm2). Fenestration size in the maxillary arch was more likely to be underestimated than in the mandibular arch (P < .0001). Vertical bone height was also underestimated when measured on CBCT imaging. CONCLUSIONS: Based on the findings of this study, LFOV CBCT imaging accurately identifies the presence or absence of buccal plate fenestrations, yet, when a fenestration is present, underestimates its area.


Assuntos
Endodontia , Endodontistas , Adulto , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Masculino , Microcirurgia , Estudos Prospectivos
15.
Artigo em Inglês | MEDLINE | ID: mdl-33923047

RESUMO

The COVID-19 pandemic has undoubtedly affected education at all levels, including medical and dental education. Our study aimed to assess the effectiveness of the blended learning in conservative dentistry with endodontics. The students had theoretical classes in a remote form (using the e-learning portal and Teams communicator) and practical classes with the participation of patients in the appropriate sanitary regime. The author's survey was conducted among fourth-year dental students. The online questionnaire consisted of 5 parts: self-evaluation, evaluation of theoretical e-learning classes, evaluation of practical clinical classes, evaluation of safety, and evaluation of performed blended learning. The majority of respondents declared that their learning effectiveness increased during the pandemic. Most surveyed students preferred remote learning in asynchronous form (e-learning portals) to synchronous form (virtual meetings in real-time). All respondents described the provided personal protective equipment as sufficient or even as excessive. Our students were very satisfied with the proposed blended-learning model and would like to continue it even after the pandemic has ended. Among the advantages, they particularly mentioned the increase in efficiency and the individualised pace of learning, while the disadvantage was the limitation of social contacts. The appropriate use of modern technology can effectively revolutionise dental education.


Assuntos
COVID-19 , Educação à Distância , Endodontia , Humanos , Pandemias/prevenção & controle , SARS-CoV-2 , Inquéritos e Questionários
16.
Molecules ; 26(6)2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33804019

RESUMO

Therapeutic success in endodontic treatment depends on successful infection control. Alexidine dihydrochloride (ALX) was recently proposed as a potential alternative to 2% chlorhexidine (CHX) as it possesses similar antimicrobial properties, expresses substantivity and does not produce p-chloroaniline (PCA) when mixed with sodium hypochlorite (NaOCl). However, the products released in this reaction have not been described to date. The aim of this study was to identify detected chemical compounds formed in the reaction of ALX and NaOCl with the ultra-high-performance liquid chromatography-mass spectrophotometry (UHPLC-MS) method and assess whether precipitates and PCA are formed in this reaction. Solutions of ALX were mixed with the equivalent volume of 2% and 5.25% (w/v) NaOCl solutions. As control, 2% (w/v) CHX was mixed with 2% and 5.25% (w/v) NaOCl. Samples were subjected to the UHPLC-MS analysis. The mixture of ALX and NaOCl resulted in a yellowish precipitate formation, the amount of which depended on NaOCl concentration. Interaction of ALX and NaOCl resulted in the production of aliphatic amines. No PCA was formed when NaOCl was mixed with ALX. However, for the first time, we identified the possible products of the interaction. The interaction between NaOCl and ALX results in the formation of aliphatic amines; therefore, these compounds should not be mixed during endodontic treatment.


Assuntos
Biguanidas/efeitos adversos , Biguanidas/farmacologia , Hipoclorito de Sódio/efeitos adversos , Hipoclorito de Sódio/farmacologia , Aminas/farmacologia , Antibacterianos/efeitos adversos , Antibacterianos/farmacologia , Clorexidina/farmacologia , Cromatografia Líquida de Alta Pressão/métodos , Endodontia/métodos , Humanos
17.
J Endod ; 47(7): 1087-1091, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33901543

RESUMO

INTRODUCTION: Cone-beam computed tomographic (CBCT) imaging has had a significant impact in endodontic diagnosis and treatment planning. Previous studies have investigated provider attitudes and the use of CBCT technology, but little is known about patients' perceptions of the use of CBCT imaging in endodontics. This study assessed the perceptions of patients within a military population regarding the application of CBCT imaging for endodontic treatment. METHODS: One hundred three consecutive, volunteer patients who were treated in a military dental treatment facility and prescribed a CBCT study according to the American Association of Endodontists/American Academy of Oral and Maxillofacial Radiology guidelines were given a Likert-type survey that recorded an initial level of knowledge and attitudes regarding the use of CBCT in endodontics. After standardized patient education in the form of a 2-minute video presentation describing the applications and risks associated with CBCT technology, CBCT volumes were acquired. A second survey was administered to record the patients' perceptions of the benefits and risks associated with CBCT imaging. RESULTS: After the video, 75% of the participants had a more positive opinion of CBCT technology; 56% felt that CBCT imaging was essential, and 44% felt it was beneficial. Fifty percent of the participants reported CBCT imaging having less radiation than they previously thought, whereas 11% thought it was more radiation. A total of 85% would seek out a provider who uses CBCT imaging if treatment is needed in the future. CONCLUSIONS: When presented with basic information, most patients within a military population perceive CBCT imaging to have an important role in endodontic treatment.


Assuntos
Endodontia , Endodontistas , Militares , Tomografia Computadorizada de Feixe Cônico , Assistência Odontológica , Humanos , Percepção
19.
J Endod ; 47(6): 954-960, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33774047

RESUMO

INTRODUCTION: This proof-of-principle study aimed to demonstrate that magnetic resonance imaging (MRI) is sufficiently accurate for the detection of root canals using guided endodontics. METHODS: One hundred extracted human teeth (anterior and premolar) were mounted onto 5 mandibular and 5 maxillary models, fitted with splints designed to accommodate a thin layer of aqueous gel for indirect imaging, and scanned by MRI. After MRI and intraoral scans were aligned using planning software, access cavities were planned virtually, and templates were manufactured with computer-aided design/computer-aided manufacturing, the access cavities were prepared. Cone-beam computed tomographic scans were performed and matched with the virtual preoperative planning data to determine the accuracy of access cavity preparation in terms of deviation between planned and prepared cavities in the mesiodistal and buccolingual dimensions and angle. Descriptive statistical analysis was performed, and the mean values were compared using the t test. RESULTS: Ninety-one of 100 root canals were successfully scouted after MRI-guided access cavity preparation. The mean angle deviation was 1.82°. The mean deviation ranged from 0.21-0.31 mm at the base of the bur and from 0.28-0.44 mm at the tip of the bur. Preparation in the buccolingual dimension was significantly more precise in mandibular compared with maxillary teeth, and accuracy in the mesiodistal dimension was more precise in anterior teeth compared with premolars. CONCLUSIONS: This in vitro study demonstrated the suitability of MRI for guided endodontic access cavity preparation.


Assuntos
Cavidade Pulpar , Endodontia , Tomografia Computadorizada de Feixe Cônico , Cavidade Pulpar/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Dente Molar
20.
Int J Nanomedicine ; 16: 2087-2106, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33727815

RESUMO

Nanotechnology has substantially progressed in the past decades, giving rise to numerous possible applications in different biomedical fields. In particular, the use of nanoparticles in endodontics has generated significant interest due to their unique characteristics. As a result of their nanoscale dimensions, nanoparticles possess several properties that may enhance the treatment of endodontic infections, such as heightened antibacterial activity, increased reactivity and the capacity to be functionalized with other reactive compounds. Effective disinfection and sealing of the root canal system are the hallmarks for successful endodontic treatment. However, the presence of bacterial biofilms and resistance to endodontic disinfectants pose a significant challenge to this goal. This has encouraged the investigation of antibacterial nanoparticle-based irrigants and intracanal medicaments, which may improve the elimination of endodontic infections. In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies. Furthermore, despite the myriad of commercially available options for endodontic obturation, the "ideal" material has yet to be conceived. This has led to the development of various experimental nanoparticle-incorporated obturation materials and sealers that exhibit a range of favourable physicochemical properties including enhanced antibacterial efficacy and bioactivity. Nanoparticle applications also show promise in the field of regenerative endodontics, such as supporting the release of bioactive molecules and enhancing the biophysical properties of scaffolds. Given the constantly growing body of research in this field, this article aims to present an overview of the current evidence pertaining to the potential translational applications of nanoparticles in endodontics.


Assuntos
Endodontia , Nanopartículas/uso terapêutico , Pesquisa Médica Translacional , Humanos , Nanopartículas/efeitos adversos , Fotoquimioterapia , Medicina Regenerativa , Tratamento do Canal Radicular
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