Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 10.996
Filtrar
1.
J Drugs Dermatol ; 23(7): 504-509, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954621

RESUMO

Photoaging is a complex, ongoing process that clinically manifests as cutaneous rhytides, atrophy, laxity, dyspigmentation, telangiectasias, roughness, and mottled appearance of the skin. There is an abundance of research establishing the mechanism of ultraviolet (UV) - induced photodamage as it is a significant source of photoaging and skin cancers. While UV damage is known to induce photoaging, it is important to understand how other forms of light radiation also contribute to this process. UV only constitutes 5 to 10% of solar radiation that reaches the earth's surface. The remaining nearly 90% is evenly split between infrared and visible light radiation. Early research shows that varied skin types may elicit different photobiologic responses to light. This article presents the mechanisms and biomarkers of photodamage induced by light from across the spectrum, including UV, visible light, and infrared to better prevent and reverse the damage of photoaging in all skin types.J Drugs Dermatol. 2024;23(7):504-509.  doi:10.36849/JDD.7438.


Assuntos
Envelhecimento da Pele , Pele , Raios Ultravioleta , Envelhecimento da Pele/efeitos da radiação , Humanos , Raios Ultravioleta/efeitos adversos , Pele/efeitos da radiação , Pele/patologia , Raios Infravermelhos/efeitos adversos , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/etiologia
2.
J Drugs Dermatol ; 23(7): 538-544, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954629

RESUMO

BACKGROUND: All skin tones need to be protected from the damaging effects of solar radiation. Although mineral sunscreens offer protection, they can have a thick, greasy feel and leave a white cast, particularly on darker skin tones. Tints offset white cast and provide visible light protection; however, patients may prefer a sheer option. Therefore, a multifunctional, sheer, 100% mineral sunscreen moisturizer (MSM) with broad-spectrum SPF 50 was developed to have positive aesthetics and deliver anti-aging and skin health benefits to all skin tones.  Methods: An IRB-approved, 12-week, open-label clinical study was conducted to investigate the efficacy and tolerability of the MSM. Thirty-nine (39) females aged 35 to 60 years with moderate-severe overall facial photodamage and representing all Fitzpatrick skin types (FST) were recruited. Participants applied the MSM to the face and neck in the morning and reapplied per US Food and Drug Administration requirements. Efficacy and tolerability grading, photography, ultrasound imaging, corneometer measurements, and questionnaires were completed at baseline and weeks 4, 8, and 12.  Results: Statistically significant progressive improvements were demonstrated from baseline to week 12. At week 12, 23.4% and 26.5% mean improvements in overall photodamage were seen for FST I-III and FST IV-VI, respectively. Favorable tolerability was shown for both the face and neck. Photography corroborated clinical grading, and ultrasound imaging indicated a trend in skin density improvement. The MSM was well-perceived.  Conclusion: The MSM is an efficacious and well-tolerated product for patients of all skin tones who desire a sheer, 100% mineral sunscreen moisturizer with anti-aging and skin health benefits. J Drugs Dermatol. 2024;23(7):538-544.  doi:10.36849/JDD.8082.


Assuntos
Envelhecimento da Pele , Pigmentação da Pele , Protetores Solares , Humanos , Feminino , Pessoa de Meia-Idade , Adulto , Protetores Solares/administração & dosagem , Protetores Solares/efeitos adversos , Envelhecimento da Pele/efeitos dos fármacos , Pigmentação da Pele/efeitos dos fármacos , Pigmentação da Pele/efeitos da radiação , Creme para a Pele/administração & dosagem , Creme para a Pele/efeitos adversos , Face , Resultado do Tratamento , Administração Cutânea , Fator de Proteção Solar
3.
J Drugs Dermatol ; 23(7): 551-556, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954627

RESUMO

BACKGROUND: Calcium hydroxylapatite (CaHA) dermal filler is used for a variety of aesthetic treatments; however, the safety and effectiveness of diluted CaHA for the treatment of décolleté wrinkles have not been established. OBJECTIVE: To demonstrate the effectiveness and safety of diluted CaHA (Radiesse; 1:2 CaHA:saline) injection for the improvement of décolleté wrinkles in females. METHODS: Eligible females with moderate or severe ratings on the Merz Aesthetic Scale (MAS) Decollete Wrinkles - At Rest received up to 3 injection cycles of diluted CaHA either 8 weeks apart (3 injection cycles) or 16 weeks apart (2 injection cycles). Effectiveness was evaluated by improvement on the MAS. Adverse events were recorded over a 52 week period. RESULTS: Sixteen weeks after the last treatment, the response rate (1-point improvement or greater) on the MAS Decollete Wrinkles - At Rest was 73.5% (P<0.0001; pooled sample) for all patients. The use of diluted CaHA in the decollete also demonstrated a favorable safety profile. CONCLUSIONS: Diluted CaHA is a safe and effective treatment for the improvement of decollete wrinkles in females.J Drugs Dermatol. 2024;23(7):551-556.  doi:10.36849/JDD.8261.


Assuntos
Preenchedores Dérmicos , Durapatita , Envelhecimento da Pele , Humanos , Feminino , Envelhecimento da Pele/efeitos dos fármacos , Durapatita/administração & dosagem , Durapatita/efeitos adversos , Estudos Prospectivos , Pessoa de Meia-Idade , Preenchedores Dérmicos/administração & dosagem , Preenchedores Dérmicos/efeitos adversos , Resultado do Tratamento , Técnicas Cosméticas , Adulto , Método Simples-Cego , Idoso
5.
Cells ; 13(13)2024 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-38994987

RESUMO

Skin provides a physical and immune barrier to protect the body from foreign substances, microbial invasion, and desiccation. Aging reduces the barrier function of skin and its rate of repair. Aged skin exhibits decreased mitochondrial function and prolonged low-level inflammation that can be seen in other organs with aging. Peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α), an important transcriptional coactivator, plays a central role in modulating mitochondrial function and antioxidant production. Mitochondrial function and inflammation have been linked to epidermal function, but the mechanisms are unclear. The aim of this review is to discuss the mechanisms by which PGC-1α might exert a positive effect on aged skin barrier function. Initially, we provide an overview of the function of skin under physiological and aging conditions, focusing on the epidermis. We then discuss mitochondrial function, oxidative stress, cellular senescence, and inflamm-aging, the chronic low-level inflammation observed in aging individuals. Finally, we discuss the effects of PGC-1α on mitochondrial function, as well as the regulation and role of PGC-1α in the aging epidermis.


Assuntos
Mitocôndrias , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo , Envelhecimento da Pele , Humanos , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo , Envelhecimento da Pele/fisiologia , Mitocôndrias/metabolismo , Animais , Pele/metabolismo , Pele/patologia , Envelhecimento/metabolismo , Estresse Oxidativo , Inflamação/metabolismo , Inflamação/patologia , Senescência Celular
6.
Skin Res Technol ; 30(7): e13768, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38961690

RESUMO

BACKGROUND: The majority of conventional studies on skin aging have focused on static conditions. However, in daily life, the facial skin we encounter is constantly in motion due to conversational expressions and changes in facial expressions, causing the skin to alter its position and shape, resulting in a dynamic state. Consequently, it is hypothesized that characteristics of aging not apparent in static conditions may be present in the dynamic state of the skin. Therefore, this study investigates age-related changes in dynamic skin characteristics associated with facial expression alterations. METHODS: A motion capture system measured the dynamic characteristics (delay and stretchiness of skin movement associated with expression) of the cheek skin in response to facial expressions among 86 Japanese women aged between 20 and 69 years. RESULTS: The findings revealed an increase in the delay of cheek skin response to facial expressions (r = 0.24, p < 0.05) and a decrease in the stretchiness of the lower cheek area with age (r = 0.60, p < 0.01). An increasing variance in delay and stretchiness within the same age group was also observed with aging. CONCLUSION: The findings of this study revealed that skin aging encompasses both static characteristics, such as spots, wrinkles, and sagging, traditionally studied in aging research, and dynamic aging characteristics of the skin that emerge in response to facial expression changes. These dynamic aging characteristics could pave the way for the development of new methodologies in skin aging analysis and potentially improve our understanding and treatment of aging impressions that are visually perceptible in daily life but remain unexplored.


Assuntos
Bochecha , Expressão Facial , Envelhecimento da Pele , Humanos , Feminino , Bochecha/fisiologia , Pessoa de Meia-Idade , Adulto , Envelhecimento da Pele/fisiologia , Idoso , Japão , Adulto Jovem , Movimento/fisiologia , Pele , Envelhecimento/fisiologia , Fenômenos Fisiológicos da Pele , População do Leste Asiático
7.
Photodermatol Photoimmunol Photomed ; 40(4): e12987, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38968385

RESUMO

BACKGROUND: Skin microbiota is essential for health maintenance. Photoaging is the primary environmental factor that affects skin homeostasis, but whether it influences the skin microbiota remains unclear. OBJECTIVE: The objective of this study is to investigate the relationship between photoaging and skin microbiome. METHODS: A cohort of senior bus drivers was considered as a long-term unilateral ultraviolet (UV) irradiated population. 16S rRNA amplicon sequencing was conducted to assess skin microbial composition variations on different sides of their faces. The microbiome characteristics of the photoaged population were further examined by photoaging guinea pig models, and the correlations between microbial metabolites and aging-related cytokines were analyzed by high-throughput sequencing and reverse transcription polymerase chain reaction. RESULTS: Photoaging decreased the relative abundance of microorganisms including Georgenia and Thermobifida in human skin and downregulated the generation of skin microbe-derived antioxidative metabolites such as ectoin. In animal models, Lactobacillus and Streptobacillus abundance in both the epidermis and dermis dropped after UV irradiation, resulting in low levels of skin antioxidative molecules and leading to elevated expressions of the collagen degradation factors matrix metalloproteinase (MMP)-1 and MMP-2 and inflammatory factors such as interleukin (IL)-1ß and IL-6. CONCLUSIONS: Skin microbial characteristics have an impact in photoaging and the loss of microbe-derived antioxidative metabolites impairs skin cells and accelerates the aging process. Therefore, microbiome-based therapeutics may have potential in delaying skin aging.


Assuntos
Microbiota , Envelhecimento da Pele , Pele , Raios Ultravioleta , Humanos , Animais , Cobaias , Pele/microbiologia , Pele/metabolismo , Masculino , Feminino , Pessoa de Meia-Idade , RNA Ribossômico 16S
8.
Skin Res Technol ; 30(7): e13669, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38965805

RESUMO

BACKGROUND: To date, studies examining the effect of air pollution on skin characteristics have relied on regional pollution estimates obtained from fixed monitoring sites. Hence, there remains a need to characterize the impact of air pollution in vivo in real-time conditions. We conducted an initial investigation under real-life conditions, with the purpose of characterizing the in vivo impact of various pollutants on the facial skin condition of women living in Paris over a 6-month period. MATERIALS AND METHODS: A smartphone application linked to the Breezometer platform was used to collect participants' individual exposures to pollutants through the recovery of global positioning system (GPS) data over a 6-month period. Daily exposure to fine particulate matter (PM 2.5 µm and PM 10 µm), pollen, and air quality was measured. Facial skin color, roughness, pore, hydration, elasticity, and wrinkle measurements were taken at the end of the 6-month period. Participants' cumulated pollutant exposure over 6 months was calculated. Data were stratified into two groups (lower vs. higher pollutant exposure) for each pollutant. RESULTS: 156 women (20-60 years-old) were recruited, with 124 women completing the study. Higher PM 2.5 µm exposure was associated with altered skin color and increased roughness under the eye. Higher PM 10 µm exposure with increased wrinkles and roughness under the eye, increased pore appearance, and decreased skin hydration. Exposure to poorer air quality was linked with increased forehead wrinkles and decreased skin elasticity, while higher pollen exposure increased skin roughness and crow's feet. CONCLUSION: This study suggests a potential correlation between air pollution and facial skin in real-life conditions. Prolonged exposure to PM, gases, and pollen may be linked to clinical signs of skin ageing. This study highlights the importance of longer monitoring over time in real conditions to characterize the effect of pollution on the skin.


Assuntos
Poluição do Ar , Exposição Ambiental , Face , Material Particulado , Envelhecimento da Pele , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Adulto Jovem , Poluição do Ar/efeitos adversos , Exposição Ambiental/efeitos adversos , Monitoramento Ambiental/métodos , Sistemas de Informação Geográfica , Paris , Material Particulado/efeitos adversos , Pólen , Pele/efeitos dos fármacos , Envelhecimento da Pele/efeitos dos fármacos , Smartphone , População Branca
10.
J Eur Acad Dermatol Venereol ; 38 Suppl 4: 45-52, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38881437

RESUMO

Anti-aging trends in Australia have changed considerably since the country emerged from the lockdowns associated with the SARS-Cov2 pandemic. People now rely on social media influencers for skin care advice and skin care products, including professional skin care treatments that can be purchased on Internet platforms. The quest for the perfect 'zoom face' led to a 300% rise in cosmetic procedures across Australia in the year to April 2021. People now want to use less products on their skin, while looking healthy and natural (termed 'skin minimalism'). The popularity of retinoid derivatives for preventing wrinkles has been superseded by non-irritating actives like hyaluronic acid (HA) and niacinamide that provide skin barrier protection, skin hydration, plumping and anti-inflammatory effects. Botulinum toxin injections remain the most popular non-surgical cosmetic procedure, followed by HA fillers, and biostimulators that promote the synthesis of collagen and give longer lasting but more gradual results than HA fillers. Laser resurfacing is widely used for epidermal resurfacing and skin tightening, as well as non-ablative lasers, intense pulsed light and radiofrequency or ultrasound skin tightening devices. Superficial chemical peels are still popular because they are relatively gentle, inexpensive, and require no downtime, whereas medium-to-deep chemical peels have largely been superseded by laser technology. However, the most efficient approach to prevent skin aging is adopting a healthy lifestyle and taking action against all factors of the skin aging exposome.


Assuntos
Técnicas Cosméticas , Envelhecimento da Pele , Humanos , Austrália , Técnicas Cosméticas/tendências , COVID-19/prevenção & controle , COVID-19/epidemiologia , Ácido Hialurônico/uso terapêutico , Preenchedores Dérmicos/uso terapêutico
11.
J Eur Acad Dermatol Venereol ; 38 Suppl 4: 36-44, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38881450

RESUMO

Skin aging is the result of physiological changes determined by genetically driven processes and intrinsic factors, and exacerbated by a combination of multiple environmental factors, the main one being sun exposure. The effects of photoaging are particularly apparent on the face, where the appearance of aging signs can have a significant impact on the emotions conveyed and well-being. Photoprotection and facial skin care for managing photoaging signs are thus of particular importance for both physical and mental health. Countries, like Australia and Brazil, where the level of sun exposure is high and the populations have predominantly outdoor lifestyles, are particularly aware of the harms of photoaging and have implemented several measures to help reduce the risk of skin cancer in their populations. However, sun-seeking behaviours are difficult to change, and it takes time before interventions provide perceptible results. Australia still has some of the highest skin cancer incidence and mortality rates in the world. Solutions that target individuals can also be used for minimizing the clinical signs of facial aging and for improving skin quality, with the ultimate aim being not only to improve the appearance of the skin but also to mitigate the occurrence of pre-malignant and malignant lesions. This review summarizes the features of facial skin photoaging in photo-exposed populations, based on evidence gained from studies of Australian individuals, and discusses the various available solutions for skin photoaging, in particular those that are most popular in Brazil, which is a country with many years of experience in managing photoaged skin.


Assuntos
Cosmecêuticos , Envelhecimento da Pele , Luz Solar , Protetores Solares , Humanos , Brasil , Austrália , Luz Solar/efeitos adversos , Protetores Solares/uso terapêutico , Cosmecêuticos/uso terapêutico , Neoplasias Cutâneas/prevenção & controle , Neoplasias Cutâneas/etiologia , Face
12.
J Eur Acad Dermatol Venereol ; 38 Suppl 4: 15-22, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38881445

RESUMO

Skin aging has long been considered a purely cosmetic problem. However, as life expectancy increases, skin aging is taking on a functional dimension that goes beyond cosmetics and appearance. Preventive or therapeutic strategies are needed to target cellular senescence, a key process underlying the alterations in skin function and appearance that occur with aging, as well as to address the age-related skin changes associated with 'dermatoporosis' and chronic skin insufficiency/fragility syndrome. Thus, given the need for effective anti-aging products that improve both the appearance and function of the skin, it is essential to distinguish active ingredients that have been proven to be effective, among the large number of available over-the-counter cosmeceuticals. This brief review focuses on a core group of topical actives, describing their clinical effects on senescence and aging, and their molecular mechanisms of action. These actives include hyaluronic acid, which has hydrating and viscoelastic properties and has been shown to reduce skin atrophy; retinaldehyde, which activates retinoid receptors and increases cutaneous elasticity; vitamins C and E, which provide stable oxidative protection; and niacinamide, which reduces inflammation and mitigates the effects of senescence.


Assuntos
Senescência Celular , Envelhecimento da Pele , Envelhecimento da Pele/efeitos dos fármacos , Envelhecimento da Pele/fisiologia , Humanos , Senescência Celular/efeitos dos fármacos , Ácido Hialurônico/farmacologia , Ácido Ascórbico/farmacologia , Ácido Ascórbico/uso terapêutico , Niacinamida/farmacologia , Niacinamida/uso terapêutico , Vitamina E/farmacologia , Cosmecêuticos/farmacologia , Pele/patologia , Pele/efeitos dos fármacos
13.
J Eur Acad Dermatol Venereol ; 38 Suppl 4: 23-35, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38881448

RESUMO

Management of the signs of facial aging and other cosmetic skin problems have greatly evolved in the past years. People are also seeking to improve their well-being and global skin appearance, and when they consider using cosmetic procedures, they expect natural and long-lasting aesthetic results. Combined dermocosmetic approaches that address the signs of facial aging at all levels are increasingly being used by dermatologists to meet patient expectations while ensuring their safety. Minimally invasive and reversible procedures that can be performed in only one session are popular approaches for skin restructuring and volumizing as they are flexible, rapid and less burdensome for patients. These interventions can achieve even better outcomes when they are combined with cosmeceuticals as pre- or post-procedural adjuvants to prepare the skin, accelerate recovery and sustain results. The use of topical dermocosmetics is also recommended as part of the daily skin care routine to improve skin quality and help maintain skin barrier function. This review thus outlines the most commonly used combined multilevel anti-aging strategies, which start by addressing the deepest skin layers and then the more superficial signs of skin aging. Examples of multi-active cosmeceuticals and skin delivery enhancing systems are also presented, together with examples of the use of dermocosmetics as supportive care for aesthetic procedures, to provide insights into current applications of dermocosmetic products.


Assuntos
Cosmecêuticos , Técnicas Cosméticas , Envelhecimento da Pele , Humanos , Envelhecimento da Pele/efeitos dos fármacos , Face
14.
J Eur Acad Dermatol Venereol ; 38 Suppl 4: 5-14, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38881451

RESUMO

Senescence and epigenetic alterations are two important hallmarks of cellular aging. During aging, cells subjected to stress undergo many cycles of damage and repair before finally entering either apoptosis or senescence, a permanent state of cell cycle arrest. The first biomarkers of senescence to be identified were increased ß-galactosidase activity and induction of p16INK4a. Another feature of senescent cells is the senescence-associated secretory phenotype (SASP), a complex secretome containing more than 80 pro-inflammatory factors including metalloproteinases, growth factors, chemokines and cytokines. The secretome is regulated through a dynamic process involving a self-amplifying autocrine feedback loop and activation of the immune system. Senescent cells play positive and negative roles depending on the composition of their SASP and may participate in various processes including wound healing and tumour suppression, as well as cell regeneration, embryogenesis, tumorigenesis, inflammation and finally aging. The SASP is also a biomarker of age, biological aging and age-related diseases. Recent advances in anti-age research have shown that senescence can be now prevented or delayed by clearing the senescent cells or mitigating the effects of SASP factors, which can be achieved by a healthy lifestyle (exercise and diet), and senolytics and senomorphics, respectively. An alternative is tissue rejuvenation, which can be achieved by stimulating aged stem cells and reprogramming deprogrammed aged cells. These non-clinical findings will open up new avenues of clinical research into the development of treatments capable of preventing or treating age-related pathologies in humans.


Assuntos
Senescência Celular , Envelhecimento da Pele , Humanos , Envelhecimento da Pele/fisiologia , Fenótipo Secretor Associado à Senescência , Rejuvenescimento/fisiologia , Envelhecimento/fisiologia , Biomarcadores/metabolismo , Senoterapia
15.
Skin Res Technol ; 30(6): e13604, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38858846

RESUMO

BACKGROUND: Many consumers use cosmetic eye products to counteract age-related changes in appearance. Measurements of eyelid shape in Asian women have been reported in the frontal view or 45-degree profile only. The aim of this study was to describe morphological characteristics of the upper eyelid in Japanese and Chinese females from the frontal and profile aspects and examine morphological changes with age. MATERIALS AND METHODS: Standardized digital photographs of 772 Japanese and 346 Chinese women (15-79 years of age) were acquired in frontal and 90-degree profile aspects. Eleven upper eyelid parameters (e.g., width, length, depth, aperture, and curvature) were measured using image analysis to determine age-related changes and compare by ethnicity. RESULTS: Eyelid width, area between eyebrow and eyelid, and eyelid curvature were comparable for both ethnicities under age 40, but the aging effect was more pronounced in Chinese subjects. Eyelid height, depth, and upper eyelid aperture angle were also comparable for both ethnicities under age 40, but the aging effect was more evident in Japanese subjects. Upper eyelid incline angle, eye orientation, and upper eyelid protrusion angle changed comparably with age for both ethnicities. No prominent age-related changes were evident for eyelid length or area between eyebrow and eye with the eye closed. CONCLUSION: Upper eyelid morphology changes with age in Japanese and Chinese females, starting around 40 years of age. Ethnic differences are limited in younger age groups but become more prominent with age. The findings suggest that aging affects some upper eyelid features earlier than others.


Assuntos
Envelhecimento , Povo Asiático , Pálpebras , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Adulto Jovem , Envelhecimento/etnologia , Envelhecimento/patologia , Envelhecimento/fisiologia , China , População do Leste Asiático , Pálpebras/anatomia & histologia , Pálpebras/diagnóstico por imagem , Japão , Fotografação , Envelhecimento da Pele/etnologia , Envelhecimento da Pele/patologia , Envelhecimento da Pele/fisiologia
16.
Cell Death Dis ; 15(6): 443, 2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38914551

RESUMO

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the endocrine organ for the maintenance of skin homeostasis undergo significant changes during skin aging. Dermal white adipose tissue (dWAT) has recently been recognized as an important organ for both non-metabolic and metabolic health in skin regeneration and rejuvenation. Defective differentiation, adipogenesis, improper adipocytokine production, and immunological dissonance dysfunction in dWAT lead to age-associated clinical changes. Here, we review age-related alterations in dWAT across levels, emphasizing the mechanisms underlying the regulation of aging. We also discuss the pathogenic changes involved in age-related fat dysfunction and the unfavorable consequences of accelerated skin aging, such as chronic inflammaging, immunosenescence, delayed wound healing, and fibrosis. Research has shown that adipose aging is an early initiation event and a potential target for extending longevity. We believe that adipose tissues play an essential role in aging and form a potential therapeutic target for the treatment of age-related skin diseases. Further research is needed to improve our understanding of this phenomenon.


Assuntos
Envelhecimento , Homeostase , Envelhecimento da Pele , Humanos , Envelhecimento/patologia , Envelhecimento/fisiologia , Envelhecimento da Pele/fisiologia , Animais , Pele/patologia , Pele/metabolismo , Tecido Adiposo Branco/metabolismo , Adipogenia
17.
Exp Dermatol ; 33(6): e15096, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38922774

RESUMO

While the evidence for the implication of opioid receptors (OPr) in ageing is growing, there is, to our knowledge, no study focusing directly on changes in vivo cutaneous OPr expression with increasing age. We thus investigated OPr expression in 30 healthy female Asian volunteers in Southern China whose ages range from the early 20s to the early 60s. Excisional biopsies were taken from the sun-exposed extensor area of the lower arm and the photo-protected area of the upper inner arm. The thickness of the epidermal layers, melanin content, as well as expression of mu-opioid receptors (MOPr) and delta-opioid receptors (DOPr) were compared between different age ranges and photo-exposure status. Significant increased epidermal hypertrophy on the extensor surface was observed. There was significant reduction of DOPr in the epidermis with increasing age, independent of photo-ageing. The increase of melanin was significantly correlated with epidermal DOPr expression, not with MOPr expression. DOPr expression could thus serve as a marker for real biological ageing unaffected by chronic photo-exposure. Additionally, DOPr expression was inversely correlated with the deposition of melanin. Based on these results, we hypothesise that regulation of DOPr expression could be used to improve aged skin, including hyperpigmentation.


Assuntos
Povo Asiático , Melaninas , Receptores Opioides delta , Envelhecimento da Pele , Humanos , Feminino , Melaninas/metabolismo , Melaninas/biossíntese , Adulto , Receptores Opioides delta/metabolismo , Pessoa de Meia-Idade , Adulto Jovem , Epiderme/metabolismo , Receptores Opioides mu/metabolismo , China
18.
Arch Dermatol Res ; 316(6): 326, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38822910

RESUMO

Skin aging is one of the visible characteristics of the aging process in humans. In recent years, different biological clocks have been generated based on protein or epigenetic markers, but few have focused on biological age in the skin. Arrest the aging process or even being able to restore an organism from an older to a younger stage is one of the main challenges in the last 20 years in biomedical research. We have implemented several machine learning models, including regression and classification algorithms, in order to create an epigenetic molecular clock based on miRNA expression profiles of healthy subjects to predict biological age-related to skin. Our best models are capable of classifying skin samples according to age groups (18-28; 29-39; 40-50; 51-60 or 61-83 years old) with an accuracy of 80% or predict age with a mean absolute error of 10.89 years using the expression levels of 1856 unique miRNAs. Our results suggest that this kind of epigenetic clocks arises as a promising tool with several applications in the pharmaco-cosmetic industry.


Assuntos
Epigênese Genética , Aprendizado de Máquina , MicroRNAs , Envelhecimento da Pele , Pele , Humanos , MicroRNAs/genética , Pessoa de Meia-Idade , Idoso , Adulto , Envelhecimento da Pele/genética , Idoso de 80 Anos ou mais , Pele/metabolismo , Pele/patologia , Feminino , Adulto Jovem , Masculino , Adolescente , Perfilação da Expressão Gênica , Relógios Biológicos/genética
19.
Arch Dermatol Res ; 316(7): 378, 2024 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-38850450

RESUMO

Hydroquinone has been used for years for multiple conditions, including melasma, post-inflammatory hyperpigmentation, dyschromia from photoaging, and solar lentigines. It is known to be a very effective lightening agent, but several concerns have been raised about this widely used agent. The recent U.S. ban on over-the-counter skin lightening products containing hydroquinone has prompted further questioning of the safety of this widely used agent. While there have been prior informative, large-scale reviews on the safety of hydroquinone, new findings have since been reported. Here, we provide an updated review of studies published in the past 15 years on hydroquinone safety.


Assuntos
Hidroquinonas , Preparações Clareadoras de Pele , Hidroquinonas/efeitos adversos , Humanos , Preparações Clareadoras de Pele/efeitos adversos , Hiperpigmentação/induzido quimicamente , Melanose/tratamento farmacológico , Envelhecimento da Pele/efeitos dos fármacos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...