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1.
Texto & contexto enferm ; 29: e20180235, Jan.-Dec. 2020. tab
Artigo em Inglês | LILACS, BDENF - Enfermagem | ID: biblio-1101982

RESUMO

ABSTRACT Objective: to disclose knowledge and practices related to active aging based on the educational and care-related dialogical proposal with professionals from the Family Health Strategy. Method: a convergent care research developed with professionals from the Family Health Strategy, in a municipality in the Central North area of Paraná-Brazil. Data was collected through interviews with 14 professionals with an average duration of 12 minutes followed by a Culture Circle with four professionals and a duration of 59 minutes, following the educational stages of the same, namely: investigation, thematization and disclosure. The premises of Freire's dialogicity were used as a theoretical framework. Results: the data show that professionals have different conceptions about aging, distinct ways of conceptualizing active aging, and scarcity of systematization for the care of the robust elderly. These findings were the basis for the dialogical educational design that allowed to transform and build new knowledge on the theme. Conclusion: the educational and care-related dialogical pathway allowed the collective definition of aging and the understanding of active aging, thus making it possible to advance towards the promotion of comprehensive care for the elderly. The convergent care research approach is shown to be effective for studies of an educational dialogic nature due to its insertion in the context of study and collective construction based on reality.


RESUMEN Objetivo: revelar saberes y prácticas sobre el envejecimiento activo a partir de la propuesta dialógica educativa/de atención con profesionales de la Estrategia de Salud de la Familia. Método: investigación convergente asistencial desarrollada con profesionales de la Estrategia de Salud de la Familia en un municipio del área centro-norte de Paraná-Brasil. Los datos se recolectaron por medio de entrevistas de 12 minutos de duración media con 14 profesionales, seguidas por un Círculo de Cultura de 59 minutos de duración con cuatro profesionales, para luego seguir con las etapas educativas del mismo, a saber: investigación, tematización y revelación. Como referencial teórico se utilizaron las premisas de la dialogicidad de Freire. Resultados: los datos demuestran que los profesionales tienen diversas concepciones sobre el envejecimiento, distintas formas de conceptualizar el envejecimiento activo y escasa capacidad de sistematización para cuidar al anciano robusto. Estos hallazgos fueron la base para el delineamiento educativo dialógico que permitió transformar y construir nuevos saberes sobre la temática. Conclusión: el itinerario dialógico educativo y relacionado con la atención permitió definir el envejecimiento en forma colectiva y comprender el envejecimiento activo, posibilitando así el avance en la promoción del cuidado integral a los ancianos. El enfoque de la investigación convergente asistencial se presenta como un medio eficaz para estudios de tinte educativo y dialógico con su inserción en el contexto del estudio y la construcción colectiva pautada en la realidad.


RESUMO Objetivo: desvelar saberes e práticas sobre envelhecimento ativo a partir da proposta educativo-cuidativo dialógica com profissionais da Estratégia Saúde da Família. Método: pesquisa convergente assistencial desenvolvida com profissionais da Estratégia Saúde da Família, em um município do Norte Central do Paraná-Brasil. Os dados foram coletados por meio de entrevista com 14 profissionais com duração média de 12 minutos seguida de Círculo de Cultura com quatro profissionais e duração de 59 minutos, seguindo as etapas educativas do mesmo, a saber: investigação, tematização e desvelamento. As premissas da dialogicidade de Freire foram utilizadas como referencial teórico. Resultados: os dados demostram que os profissionais têm: concepções diversas sobre o envelhecer; distintas formas de conceituar o envelhecimento ativo e escassez de sistematização para o cuidado ao idoso robusto. Esses achados foram a base para o delineamento educativo dialógico que permitiu transformar e construir novos saberes sobre a temática. Conclusão: o percurso cuidativo-educativo dialógico permitiu a definição coletiva sobre envelhecimento e a compreensão sobre o envelhecer ativo, possibilitando assim, avançar para a promoção do cuidado integral ao idoso. A abordagem de pesquisa convergente assistencial apresenta-se como eficaz para estudos de cunho educativo dialógico pela inserção no contexto de estudo e construção coletiva pautada na realidade.


Assuntos
Atenção Primária à Saúde , Envelhecimento , Saúde da Família , Saúde do Idoso , Educação Continuada , Estratégia Saúde da Família
2.
Rev. esp. geriatr. gerontol. (Ed. impr.) ; 55(5): 272-278, sept.-oct. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-193032

RESUMO

OBJETIVOS: Analizar si existen diferencias en función de la edad en ansiedad, tristeza, soledad y comorbilidad ansioso-depresiva en personas jóvenes, de mediana edad y mayores confinadas debido a la pandemia de la COVID-19, y explorar la relación entre la autopercepción negativa del envejecimiento y nivel de sintomatología psicológica en función del grupo de edad. MÉTODO: Participan 1.501 personas (rango de edad: 18 a 88 años). Se evaluaron el grado de ansiedad, tristeza y soledad, y la autopercepción del envejecimiento. Se dividió a la muestra en función del grupo de edad y por cuartiles (bajo, intermedios y alto) en ansiedad, tristeza, soledad y autopercepción del envejecimiento. RESULTADOS: Las personas mayores informan de menor ansiedad y tristeza que los de mediana edad y jóvenes, y los de mediana edad de menores niveles que los jóvenes. Los de mediana edad informan de menor soledad, seguidos de los mayores y los jóvenes. Para cada grupo de edad, aquellos con una alta autopercepción negativa del envejecimiento informan de mayor ansiedad, tristeza y soledad. Hay más comorbilidad ansioso-depresiva en jóvenes y menos en mayores; más personas deprimidas en mediana edad, menos mayores con ansiedad, y más mayores y menos jóvenes sin sintomatología ansiosa y depresiva. Para todos los grupos de edad, las personas con comorbilidad ansioso-depresiva son las que tienen puntuaciones altas en autopercepción negativa del envejecimiento. CONCLUSIONES: Las personas mayores informan de menos malestar psicológico que otros grupos de edad. Tener una alta autopercepción negativa del envejecimiento perjudica a la salud psicológica, independientemente de la edad


OBJECTIVES: To analyze differences by age group in anxiety, depression, loneliness and comorbid anxiety and depression in young people, middle aged adults and older adults during the lock-down period at home due to the COVID-19 pandemic, and to explore the association between negative self-perceptions of aging and psychological symptoms controlling by age group. METHOD: Participants are 1501 people (age range 18 to 88 years). Anxiety, sadness, loneliness and self-perceptions of aging were assessed. The sample was divided according to the age group and quartiles (lower, intermediate levels, and higher) of anxiety, sadness, loneliness and self-perceptions of aging. RESULTS: Older adults reported lower levels of anxiety and sadness than middle aged adults, and middle aged adults reported lower levels than younger participants. Middle aged adults reported the lowest loneliness, followed by older adults and younger participants. For each age group, those with more negative self-perceptions of aging reported higher anxiety, sadness and loneliness. More comorbid anxiety and sadness was found in younger adults and less in older adults; more depressed participants in the middle aged group, and more older adults and less younger participants were found in the group with the lowest levels of anxiety and sadness. For all the age groups, participants with high levels of comorbid anxiety and sadness are those who report the highest scores in negative self-perceptions of aging. CONCLUSIONS: Older adults reported lower psychological anxiety, sadness and loneliness than the other age groups. Having negative self-perceptions of aging damage psychological health irrespective of the chronological age


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Infecções por Coronavirus/epidemiologia , Quarentena/psicologia , Envelhecimento/psicologia , Autoimagem , Solidão/psicologia , Depressão/psicologia , Ansiedade/epidemiologia , Adaptação Psicológica , Inquéritos de Morbidade , Pandemias , Fatores Etários , Questionário de Saúde do Paciente/estatística & dados numéricos , Transtornos de Adaptação/epidemiologia
3.
Nat Commun ; 11(1): 4796, 2020 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-32963231

RESUMO

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/ß-catenin, TGF-ß and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.


Assuntos
Envelhecimento/genética , Encéfalo , Estudo de Associação Genômica Ampla , Transtornos Mentais/genética , Doenças Neurodegenerativas/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Estruturas Cromossômicas , Cognição , Feminino , Genômica , Humanos , Masculino , Pessoa de Meia-Idade , Fenótipo , Polimorfismo de Nucleotídeo Único
5.
Nat Commun ; 11(1): 4413, 2020 09 04.
Artigo em Inglês | MEDLINE | ID: mdl-32887883

RESUMO

The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive. Here, we report zonation-dependent transcriptomic changes in aged mouse brain endothelial cells (ECs), which prominently implicate altered immune/cytokine signaling in ECs of all vascular segments, and functional changes impacting the blood-brain barrier (BBB) and glucose/energy metabolism especially in capillary ECs (capECs). An overrepresentation of Alzheimer disease (AD) GWAS genes is evident among the human orthologs of the differentially expressed genes of aged capECs, while comparative analysis revealed a subset of concordantly downregulated, functionally important genes in human AD brains. Treatment with exenatide, a glucagon-like peptide-1 receptor agonist, strongly reverses aged mouse brain EC transcriptomic changes and BBB leakage, with associated attenuation of microglial priming. We thus revealed transcriptomic alterations underlying brain EC ageing that are complex yet pharmacologically reversible.


Assuntos
Envelhecimento/patologia , Barreira Hematoencefálica , Encéfalo/fisiopatologia , Células Endoteliais/metabolismo , Exenatida/farmacologia , Doença de Alzheimer/fisiopatologia , Animais , Barreira Hematoencefálica/efeitos dos fármacos , Barreira Hematoencefálica/fisiopatologia , Capilares/metabolismo , Células Cultivadas , Humanos , Camundongos , Microglia/efeitos dos fármacos , Doenças Neurodegenerativas/fisiopatologia , Transcriptoma/efeitos dos fármacos
6.
Nat Commun ; 11(1): 4618, 2020 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-32934233

RESUMO

The identification of genes and interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty Indices (FIs) in mice are composite measures of health that are cost-effective and non-invasive, but whether they can accurately predict health and lifespan is not known. Here, mouse FIs are scored longitudinally until death and machine learning is employed to develop two clocks. A random forest regression is trained on FI components for chronological age to generate the FRIGHT (Frailty Inferred Geriatric Health Timeline) clock, a strong predictor of chronological age. A second model is trained on remaining lifespan to generate the AFRAID (Analysis of Frailty and Death) clock, which accurately predicts life expectancy and the efficacy of a lifespan-extending intervention up to a year in advance. Adoption of these clocks should accelerate the identification of longevity genes and aging interventions.


Assuntos
Envelhecimento/fisiologia , Camundongos/fisiologia , Envelhecimento/genética , Animais , Relógios Biológicos , Feminino , Fragilidade , Humanos , Expectativa de Vida , Aprendizado de Máquina , Masculino , Camundongos/genética , Camundongos/crescimento & desenvolvimento , Camundongos Endogâmicos C57BL
8.
BMC Public Health ; 20(1): 1373, 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32907578

RESUMO

BACKGROUND: Sleep deprivation is often claimed to be increasingly common, but most studies show small changes in sleep duration over the last decades. Our aim was to analyze long-term patterns in self-reported sleep duration in a population-based cohort. METHODS: Members of the Older Finnish Twin Cohort have responded to questionnaires in 1975 (N = 30,915 individuals, response rate 89%, mean age 36 years), 1981 (24,535, 84%, 41 years), 1990 (12,450, 77%, 44 years), and 2011 (8334, 72%, 60 years). Weibull regression models were used to model the effects of follow-up time and age simultaneously. RESULTS: Sleep duration has decreased in all adult age groups and in both genders. The mean duration was in men 7.57 h in 1975 and 7.39 in 2011, and in women 7.69 and 7.37, respectively. The decrease was about 0.5 min in men and 0.9 in women per year of follow-up. In the age-group 18-34 years, mean sleep length was 7.69 h in 1975 and 7.53 in 1990. Among 35-54-year-old it was 7.57 h in 1975 and 7.34 in 2011, and in the age group of 55+ year olds 7.52 and 7.38, correspondingly. The change was largest in middle-aged group: about 23 min or about 0.6 min per year of follow-up. CONCLUSIONS: There has been a slight decrease in mean sleep duration during the 36-year follow-up. Although the sleep duration was longer in 1970s and 1980s, the probable main cause for the change in this study population is the effect of aging.


Assuntos
Envelhecimento , Transtornos do Sono-Vigília/epidemiologia , Sono , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Finlândia/epidemiologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Autorrelato , Privação do Sono , Inquéritos e Questionários , Adulto Jovem
9.
Rev Infirm ; 69(263): 16-18, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32993896

RESUMO

The body at the intersection of the natural, social and private. Confronted with a sick body, a body which no longer enjoys the "silence of the organs" within it, an ageing, tired body, caregivers, aside from the care they provide, are faced with a symbolic dimension. At the crossroads between the private and the social spheres, in a confrontation which connects them to an ancestral practice, that of the body as a tool of perception, both "touching and touched", a site of "incorporated" consciousness, caregivers also question their relationship with their own body.


Assuntos
Cuidadores , Corpo Humano , Relações Interpessoais , Autoimagem , Envelhecimento , Doença , Humanos
10.
Emerg Med Clin North Am ; 38(4): 919-930, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32981626

RESUMO

The geriatric population is growing and is the largest utilizer of emergency and critical care services; the emergency clinician should be comfortable in the management of the acutely ill geriatric patient. There are important physiologic changes in geriatric patients, which alters their clinical presentation and management. Age alone should not determine the prognosis for elderly patients. Premorbid functional status, frailty, and severity of illness should be considered carefully for the geriatric population. Emergency clinicians should have honest conversations about goals of care based not only a patient's clinical presentation but also the patient's values.


Assuntos
Envelhecimento/fisiologia , Estado Terminal , Ressuscitação , Idoso , Cuidados Críticos , Tomada de Decisão Compartilhada , Delírio/induzido quimicamente , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Serviço Hospitalar de Emergência , Fragilidade/classificação , Humanos , Farmacocinética , Polimedicação , Ordens quanto à Conduta (Ética Médica) , Assistência Terminal , Triagem
11.
Soins Gerontol ; 25(145): 12-13, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32988480

RESUMO

Normal aging can be defined as the result of the effects of genetic and environmental factors to which subjects are exposed throughout their lives. This process is slow and progressive and must be distinguished from disease. All organs are subject to aging in a physiological way.


Assuntos
Envelhecimento/fisiologia , Sensação/fisiologia , Idoso , Humanos
12.
Soins Gerontol ; 25(145): 18-21, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32988482

RESUMO

Compared with other sensory modalities, age-related alterations in taste and smell are less known and less investigated in clinical practice. In fact, the elderly with a loss of smell or taste may not always report it or be aware of it. In addition, the clinical evaluation of taste and smell by specific tests is rarely performed.


Assuntos
Envelhecimento/fisiologia , Transtornos do Olfato/diagnóstico , Distúrbios do Paladar/diagnóstico , Idoso , Humanos , Olfato/fisiologia , Paladar/fisiologia
13.
J Frailty Aging ; 9(4): 191-196, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32996555

RESUMO

BACKGROUND: Aging results in adaptations which may affect the control of motor units. OBJECTIVE: We sought to determine if younger and older men recruit motor units at similar force levels. DESIGN: Cross-sectional, between-subjects design. SETTING: Controlled laboratory setting. PARTICIPANTS: Twelve younger (age = 25 ± 3 years) and twelve older (age = 75 ± 8 years) men. MEASUREMENTS: Participants performed isometric contractions of the dominant knee extensors at a force level corresponding to 50% maximal voluntary contraction (MVC). Bipolar surface electromyographic (EMG) signals were detected from the vastus lateralis. A surface EMG signal decomposition algorithm was used to quantify the recruitment threshold of each motor unit, which was defined as the force level corresponding to the first firing. Recruitment thresholds were expressed in both relative (% MVC) and absolute (N) terms. To further understand age-related differences in motor unit control, we examined the mean firing rate versus recruitment threshold relationship at steady force. RESULTS: MVC force was greater in younger men (p = 0.010, d = 1.15). Older men had lower median recruitment thresholds in both absolute (p = 0.005, d = 1.29) and relative (p = 0.001, d = 1.53) terms. The absolute recruitment threshold range was larger for younger men (p = 0.020; d = 1.02), though a smaller difference was noted in relative terms (p = 0.235, d = 0.50). These findings were complimented by a generally flatter slope (p = 0.070; d = 0.78) and lower y-intercept (p = 0.009; d = 1.17) of the mean firing rate versus recruitment threshold relationship in older men. CONCLUSION: Older men tend to recruit more motor units at lower force levels. We speculate that recruitment threshold compression may be a neural adaptation serving to compensate for lower motor unit firing rates and/or denervation and subsequent re-innervation in aged muscle.


Assuntos
Envelhecimento/fisiologia , Músculo Quadríceps/fisiologia , Recrutamento Neurofisiológico/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Eletromiografia , Humanos , Contração Isométrica , Masculino , Adulto Jovem
14.
J Am Med Dir Assoc ; 21(10): 1365-1370.e7, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32981662

RESUMO

During the first few months of the coronavirus disease 2019 (COVID-19) pandemic, Canadian nursing homes implemented strict no-visitor policies to reduce the risk of introducing COVID-19 in these settings. There are now growing concerns that the risks associated with restricted access to family caregivers and visitors have started to outweigh the potential benefits associated with preventing COVID-19 infections. Many residents have sustained severe and potentially irreversible physical, functional, cognitive, and mental health declines. As Canada emerges from its first wave of the pandemic, nursing homes across the country have cautiously started to reopen these settings, yet there is broad criticism that emerging visitor policies are overly restrictive, inequitable, and potentially harmful. We reviewed the nursing home visitor policies for Canada's 10 provinces and 3 territories as well as international policies and reports on the topic to develop 10 provi-informed, data-driven, and expert-reviewed guidance for the re-opening of Canadian nursing homes to family caregivers and visitors.


Assuntos
Infecções por Coronavirus/prevenção & controle , Solidão/psicologia , Casas de Saúde/organização & administração , Pandemias/prevenção & controle , Segurança do Paciente/normas , Pneumonia Viral/prevenção & controle , Isolamento Social/psicologia , Envelhecimento/psicologia , Betacoronavirus , Canadá , Infecções por Coronavirus/epidemiologia , Gerenciamento Clínico , Política de Saúde , Humanos , Pneumonia Viral/epidemiologia
15.
Rev Bras Epidemiol ; 23: e200093, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32997082

RESUMO

OBJECTIVE: Estimate the magnitude of the income inequality in the prevalence of functional dependency for basic and instrumental activities of daily life (BADLs, IADLs) and the abandonment of advanced activities (AADLs). METHODS: This was a cross-sectional, population-based study, developed using sample data of 986 elderly people from a health survey carried out in the municipality of Campinas, São Paulo, in 2014/15. The prevalence of functional dependency in BADLs and IADLs and of abandonment of the AADLs was estimated according to monthly family income per capita. A multiple regression Poisson analysis was developed to estimate the prevalence ratio (PR) adjusted by gender and age. RESULTS: There was no significant association between income and functional dependency for BADLs. Of the seven IADLs analyzed, five presented a higher prevalence of dependency in the lower-income stratum, with special highlight to using the phone (PR = 3.50), controlling medication usage (PR = 2.44), and use of transportation (PR = 2.35). The abandonment of AADLs was higher among low-income elderly people in all activities analyzed, with the greatest inequalities observed in making contact by letter, phone and e-mail (PR = 3.76), using the Internet (PR = 3.34), driving vehicles (PR = 2.85) and visiting family (PR = 2.77). CONCLUSIONS: The broad inequality detected among income stratum regarding the functional capability for the IADLs and abandonment of the AADLs emphasize the importance of fully implementing and maintaining the policies and programs directed toward the social protection of elderly adults. The focus should be on the most socially vulnerable segments, with the aim of achieving a population that is more equal, active, independent, and involved in participatory ageing.


Assuntos
Atividades Cotidianas , Renda , Adulto , Idoso , Envelhecimento , Brasil , Estudos Transversais , Humanos , Fatores Socioeconômicos
16.
Adv Respir Med ; 88(4): 335-342, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32869267

RESUMO

In early December 2019, in the city of Wuhan in Hubei Province, China, the first infections by a novel coronavirus were reported. Since then, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been spreading to other cities and countries becoming the global emerging epidemiological issue and quickly reaching the status of a pandemic. Multiple risk factors of disease severity and mortality have been identified so far. These include old age, male sex, smoking, and obesity. This concise narrative review highlights the important role of these factors in the pathobiology and clinical landscape of Coronavirus Disease 2019 (COVID-19). We especially focused on their significant role in disease severity and mortality. However, in spite of intensive research, most of the presented pieces of evidence are weak and need further verification.


Assuntos
Infecções por Coronavirus/epidemiologia , Obesidade/epidemiologia , Pneumonia Viral/epidemiologia , Fumar/epidemiologia , Fatores Etários , Envelhecimento , Feminino , Humanos , Masculino , Pandemias , Fatores de Risco , Fatores Sexuais
17.
Curr Hypertens Rep ; 22(10): 80, 2020 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-32880739

RESUMO

PURPOSE OF REVIEW: Precision Aging® is a novel concept that we have recently employed to describe how the model of precision medicine can be used to understand and define the multivariate risks that drive age-related cognitive impairment (ARCI). Hypertension and cardiovascular disease are key risk factors for both brain function and cognitive aging. In this review, we will discuss the common mechanisms underlying the risk factors for both hypertension and ARCI and how the convergence of these mechanisms may be amplified in an individual to drive changes in brain health and accelerate cognitive decline. RECENT FINDINGS: Currently, our cognitive health span does not match our life span. Age-related cognitive impairment and preventing and treating ARCI will require an in-depth understanding of the interrelated risk factors, including individual genetic profiles, that affect brain health and brain aging. Hypertension and cardiovascular disease are important risk factors for ARCI. And, many of the risk factors for developing hypertension, such as diabetes, smoking, stress, viral infection, and age, are shared with the development of ARCI. We must first understand the mechanisms common to the converging risk factors in hypertension and ARCI and then design person-specific therapies to optimize individual brain health. The understanding of the convergence of shared risk factors between hypertension and ARCI is required to develop individualized interventions to optimize brain health across the life span. We will conclude with a discussion of possible steps that may be taken to decrease ARCI and optimize an individual's cognitive life span.


Assuntos
Envelhecimento , Encéfalo/fisiopatologia , Disfunção Cognitiva , Hipertensão/complicações , Humanos , Medicina de Precisão , Fatores de Risco
18.
Cien Saude Colet ; 25(9): 3459-3464, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32876247

RESUMO

This article provides information about COVID-19, contextualizing the national and international scenario, with an emphasis on the health of the elderly. Perspectives and initiatives for this risk group are presented, reinforcing the need to consider the aging process and not just age as the main marker in the approach of this population.


Assuntos
Envelhecimento/fisiologia , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Fatores Etários , Idoso , Brasil/epidemiologia , Humanos , Pandemias , Fatores de Risco
20.
Epidemiol Infect ; 148: e197, 2020 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-32873357

RESUMO

This study estimates the incubation period of COVID-19 among locally transmitted cases, and its association with age to better inform public health measures in containing COVID-19. Epidemiological data of all PCR-confirmed COVID-19 cases from all restructured hospitals in Singapore were collected between 23 January 2020 and 2 April 2020. Activity mapping and detailed epidemiological investigation were conducted by trained personnel. Positive cases without clear exposure to another positive case were excluded from the analysis. One hundred and sixty-four cases (15.6% of patients) met the inclusion criteria during the defined period. The crude median incubation period was 5 days (range 1-12 days) and median age was 42 years (range 5-79 years). The median incubation period among those 70 years and older was significantly longer than those younger than 70 years (8 vis-à-vis 5 days, P = 0.040). Incubation period was negatively correlated with day of illness in both groups. These findings support current policies of 14-day quarantine periods for close contacts of confirmed cases and 28 days for monitoring infections in known clusters. An elderly person who may have a longer incubation period than a younger counterpart may benefit from earlier and proactive testing, especially after exposure to a positive case.


Assuntos
Envelhecimento , Betacoronavirus , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/patologia , Período de Incubação de Doenças Infecciosas , Pneumonia Viral/epidemiologia , Pneumonia Viral/patologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Singapura/epidemiologia , Adulto Jovem
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