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1.
Int J Dermatol ; 59(12): 1468-1474, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33040344

RESUMO

BACKGROUND: An association between wearing protective gear and eosinophilic folliculitis has not been reported. We aimed to investigate such during the COVID-19 pandemic. METHODS: In three outpatient clinics, we hand-reviewed records of all patients having consulted us during a Study Period (90 days) in the early phase of the pandemic. Our inclusion criteria for Study Subjects were: (i) clear clinical diagnosis, (ii) dermoscopic confirmation, (iii) differential diagnoses excluded, (iv) eosinophilia, (v) protective gear worn during sanitation services, (vi) temporal correlation, (vii) distributional correlation, (viii) physician-assessed association, and (ix) patient-assessed association. Control Periods in the same season were elected. RESULTS: Twenty-five study subjects fulfilled all inclusion criteria. The incidence was significantly higher than in the control periods (IR: 3.57, 95% CI: 1.79-7.43). Male predominance was significant (P < 0.001). Such for patients in the control periods were insignificant. Study subjects were 21.2 (95% CI: 11.0-31.4) years younger than patients in the control periods. For the study subjects, the distribution of erythematous or skin-colored folliculocentric dome-shaped papules and pustules were all compatible with body parts covered by the gear. Lesional biopsy performed on two patients revealed eosinophilic dermal infiltrates within and around the pilosebaceous units. Polarized dermoscopy revealed folliculitis with peri-/interfollicular vascular proliferation. Lesion onsets were 6.4 (SD: 2.1) days after wearing gear. Remissions were 16.7 (SD: 7.5) days after ceasing to wear gear and treatments. CONCLUSIONS: Wearing protective gear in volunteered sanitizing works could be associated with eosinophilic folliculitis. Owing to the significant temporal and distributional correlations, the association might be causal.


Assuntos
Controle de Doenças Transmissíveis/métodos , Infecções por Coronavirus/prevenção & controle , Eosinofilia/epidemiologia , Foliculite/epidemiologia , Pandemias/prevenção & controle , Equipamento de Proteção Individual/efeitos adversos , Pneumonia Viral/prevenção & controle , Dermatopatias Vesiculobolhosas/epidemiologia , Voluntários/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus/patogenicidade , Biópsia , Controle de Doenças Transmissíveis/instrumentação , Controle de Doenças Transmissíveis/normas , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/virologia , Dermoscopia , Diagnóstico Diferencial , Eosinofilia/diagnóstico , Eosinofilia/etiologia , Eosinofilia/patologia , Feminino , Foliculite/diagnóstico , Foliculite/etiologia , Foliculite/patologia , Folículo Piloso/diagnóstico por imagem , Folículo Piloso/patologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Pneumonia Viral/epidemiologia , Pneumonia Viral/virologia , Estudos Retrospectivos , Fatores de Risco , Saneamento , Fatores Sexuais , Dermatopatias Vesiculobolhosas/diagnóstico , Dermatopatias Vesiculobolhosas/etiologia , Dermatopatias Vesiculobolhosas/patologia , Fatores de Tempo , Adulto Jovem
2.
Medicine (Baltimore) ; 99(42): e22783, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33080749

RESUMO

RATIONALE: Anaplastic thyroid carcinoma (ATC) is a rare highly aggressive thyroid malignancy. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia is also a rare low grade malignant thyroid neoplasm. To date, comorbidity of these 2 tumors in the thyroid gland has not been reported in the English literature. PATIENT CONCERNS: Here, we present a case of a 67-year-old women with a 6-month history of mass of left neck. She complained of a painless mass in the right neck. DIAGNOSES: Based on histopathological examination of H&E stained sections, immunohistochemical staining assay and molecular tests, the patient was diagnosed with ATC combined with sclerosing mucoepidermoid carcinoma with eosinophilia. INTERVENTIONS: The patient underwent radical surgery for thyroid cancer. OUTCOMES: No complications, local recurrence or metastases were observed during a 1 year and 3 months follow-up after surgery. LESSONS: To the best of our knowledge, this is the first case report on ATC combined with sclerosing mucoepidermoid carcinoma with eosinophilia in the English literature. This condition can be easily misdiagnosed during thyroid fine needle cytology. Clinicians should perform morphological examination, immunohistochemistry and molecular tests on resected specimen to make a definitive diagnosis.


Assuntos
Carcinoma Mucoepidermoide/patologia , Eosinofilia/diagnóstico , Neoplasias Primárias Múltiplas/patologia , Carcinoma Anaplásico da Tireoide/patologia , Neoplasias da Glândula Tireoide/patologia , Idoso , Carcinoma Mucoepidermoide/cirurgia , Feminino , Humanos , Neoplasias Primárias Múltiplas/cirurgia , Esclerose , Carcinoma Anaplásico da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia
3.
J Cancer Res Ther ; 16(3): 581-586, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719271

RESUMO

Introduction: Eosinophils are multifunctional granulocytes, which play a pivotal role in health and disease. Tumor Associated Tissue Eosinophilia (TATE) has long been evaluated in the diagnosis and progression of oral squamous cell carcinomas (OSCCs). However, their association with Tumor Associated Blood Eosinophilia (TABE) in OSCCs is still far fetched. We, therefore, attempted to evaluate their individual roles and to achieve a ratio between TATE and TABE in order to signify its usage in objectifying the diagnosis. Materials and Methods: TATE was evaluated using H and E stain per 10 high power fields in 33 previously diagnosed cases of OSCC which were retrieved from department archives. TABE values were achieved from complete blood hemogram reports of patients. TATE/TABE ratio was calculated. All the parameters were clinicopathologically correlated and statistically evaluated using SPSS. Results: TATE represented higher values in well-differentiated squamous cell carcinoma (WDSCC) and poorly differentiated squamous cell carcinoma (PDSCC) and was least in moderately differentiated squamous cell carcinoma (MDSCC), whereas TABE linearly increased from WDSCC to PDSCC. TNM Stage II cases revealed the highest TATE and lowest TABE. TATE/TABE ratio was the highest in WDSCC. Conclusion: Due to the dual nature of eosinophils in early and late carcinogenesis events, evaluation of only TATE might not be conclusive in determining tumor grade. Hence, in a first of its kind attempt, the TATE/TABE ratio may be suitable to achieve a criterion for the determination of tumor grade and may also help to unfold the underlying biologic events.


Assuntos
Eosinofilia/patologia , Eosinófilos/patologia , Neoplasias Bucais/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Diagnóstico Diferencial , Eosinofilia/diagnóstico , Eosinofilia/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/sangue , Gradação de Tumores , Estadiamento de Neoplasias , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço/sangue , Coloração e Rotulagem/métodos
4.
Ann Biol Clin (Paris) ; 78(4): 399-409, 2020 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-32540797

RESUMO

The discovery of eosinophilia above 1.5 G/L should not be considered innocuous, requiring monitoring for etiology and possible secondary organ damage. Among these, cardiac localization is the most worrying, sometimes indolent, to be systematically sought by ultrasound and magnetic resonance. The potential etiologies are very numerous, mostly reactive and corticosensitive, much more rarely clonal in relation to a malignant hemopathy usually chronic and myeloid, sometimes sensitive to tyrosine kinase inhibitors.


Assuntos
Técnicas de Laboratório Clínico/métodos , Eosinofilia/diagnóstico , Eosinofilia/etiologia , Testes Hematológicos/métodos , Técnicas de Laboratório Clínico/história , Técnicas de Laboratório Clínico/normas , Diagnóstico Diferencial , Eosinofilia/história , Testes Hematológicos/história , Testes Hematológicos/normas , História do Século XXI , Humanos
7.
Arerugi ; 69(2): 123-128, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32188824

RESUMO

Eosinophilic esophagitis has been reported as a complication of oral immunotherapy (OIT), but there are only a few reports of eosinophilic gastroenteritis (EGE) occurring after OIT. EGE causes eosinophil infiltration into the gastrointestinal (GI) tract and is characterized by various digestive symptoms. We report the case of a 6-year-old boy with EGE. He was diagnosed as having immediate-type food allergies (egg, milk and wheat) by oral food challenges at 1 year of age. OIT for each food was carried out, and the amounts of the offending foods were able to be gradually increased without causing any immediate-type allergy symptoms. However, the total IgE and specific IgE values were remarkably increased at the age of 4 years and 4 months. He first developed oral mucosa symptoms and vomiting at 4 years and 10 months of age, and they gradually worsened. Stopping eggs and milk alleviated the symptoms. Nevertheless, he still occasionally vomited. He started Pica eating disorder (sand and sponge) due to anemia from 5 years and 10 months of age and developed eosinophilia without diarrhea or bloody stool. Upper and lower GI tract endoscopic examinations found no bleeding. The GI mucosa showed eosinophil infiltration of more than 40/high-power field in the stomach and duodenum, so he was diagnosed with EGE. No eosinophils were found in the esophageal mucosa. His GI symptoms and anemia improved on a multiple-food-elimination diet. Patients undergoing OIT should be closely followed up for a long time, and those with GI symptoms should be evaluated by GI endoscopy.


Assuntos
Enterite/diagnóstico , Eosinofilia/diagnóstico , Gastrite/diagnóstico , Imunoterapia/efeitos adversos , Pica/etiologia , Animais , Criança , Enterite/complicações , Eosinofilia/complicações , Hipersensibilidade Alimentar , Gastrite/complicações , Humanos , Masculino
8.
Trop Doct ; 50(3): 277-279, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32178592

RESUMO

Eosinophilic ascites, owing to serosal involvement, is a very rare manifestation of eosinophilic gastroenteritis in children, especially when it occurs with muscular involvement in the absence of mucosal disease, which may be confirmed by endoscopic ultrasonography. An 11-year-old girl, presenting with massive eosinophilic ascites and colicky abdominal pain with peripheral eosinophilia, raised IgE levels and positive skin prick test, had such investigation which confirmed the presence of muscle layer thickening of both stomach and small bowel. She responded well to steroids and montelukast.


Assuntos
Ascite/diagnóstico , Enterite/diagnóstico , Eosinofilia/diagnóstico , Gastrite/diagnóstico , Músculos Abdominais/diagnóstico por imagem , Músculos Abdominais/patologia , Ascite/tratamento farmacológico , Ascite/patologia , Criança , Endossonografia , Enterite/tratamento farmacológico , Enterite/patologia , Eosinofilia/tratamento farmacológico , Eosinofilia/patologia , Eosinófilos/patologia , Feminino , Gastrite/tratamento farmacológico , Gastrite/patologia , Humanos , Esteroides/uso terapêutico , Resultado do Tratamento
9.
Infect Dis Poverty ; 9(1): 16, 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-32029005

RESUMO

BACKGROUND: Loiasis is an uncommon and poorly understood parasitic disease outside endemic areas of Africa. The aim of this study was to describe the clinical and biological patterns and treatment of imported loiasis by sub-Saharan migrants diagnosed in Madrid, Spain. METHODS: A retrospective study was conducted with sub-Saharan immigrants seen at the Tropical Medicine Unit of the Carlos III Hospital in Madrid, Spain, a reference center, over 19 years. Categorical variables were expressed as frequency counts and percentages. Continuous variables were expressed as the mean and standard deviation (SD) or median and interquartile range (IQR: Q3-Q1). Chi-square tests were used to assess the association between categorical variables. The measured outcomes were expressed as the odds ratio (OR) with a 95% confidential interval. Continuous variables were compared by Student's t-tests or Mann-Whitney U tests. Binary logistic regression models were used. P <  0.05 was considered a statistically significant difference. RESULTS: One hundred thirty-one migrants from tropical and subtropical areas with loiasis were identified. Forty-nine patients were male (37.4%). The migrants' mean age (±SD) was 42.3 ± 17.3 years, and 124 (94.7%) were from Equatorial Guinea. The median time (IQR) between arrival in Spain and the first consultation was 2 (1-7) months. One hundred fifteen migrants had eosinophilia, and one hundred thirteen had hyper-IgE syndrome. Fifty-seven patients had pruritus (43.5%), and thirty patients had Calabar swelling (22.9%). Seventy-three patients had coinfections with other filarial nematodes (54.2%), and 58 migrants had only Loa loa infections (45.8%). One hundred two patients (77.9%) were treated; 45.1% (46/102) patients were treated with one drug, and 54.9% (56/102) patients were treated with combined therapy. Adverse reactions were described in 14 (10.7%) migrants. CONCLUSIONS: Our patients presented early clinical manifestations and few atypical features. Thus, physicians should systematically consider loiasis in migrants with a typical presentation. However, considering that 72.5% of the patients had only positive microfilaremia without any symptoms, we suggest searching for microfilaremia in every migrant from endemic countries for loiasis presenting with eosinophilia.


Assuntos
Loíase/epidemiologia , Adulto , Idoso , Anti-Helmínticos/uso terapêutico , Eosinofilia/diagnóstico , Eosinofilia/epidemiologia , Eosinofilia/etiologia , Guiné Equatorial/etnologia , Feminino , Humanos , Loíase/diagnóstico , Loíase/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Espanha/epidemiologia , Migrantes , Adulto Jovem
10.
Pediatrics ; 145(3)2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32075872

RESUMO

Eosinophilic gastrointestinal diseases (EGIDs) are a diverse group of intestinal diseases involving the infiltration of eosinophils into the bowel wall. EGID can present with a variety of clinical conditions, which are largely dependent on the location of eosinophils in the intestinal wall. We describe the first reported pediatric cases of EGID presenting with symptomatic partial bowel obstruction from intestinal masses due to isolated focal mural involvement. Both patients subsequently responded favorably to therapy with exclusive elemental nutrition in the first case and exclusive elemental nutrition with steroids in the second case. These cases reveal the wide-ranging clinical manifestations of EGID, expand on the differential diagnosis of focal intestinal masses, and provide guidance on the evaluation of ambiguous cases.


Assuntos
Enterite/diagnóstico , Eosinofilia/diagnóstico , Gastrite/diagnóstico , Adolescente , Enterite/complicações , Eosinofilia/complicações , Feminino , Gastrite/complicações , Humanos , Obstrução Intestinal/etiologia
11.
Rev. clín. med. fam ; 13(1): 85-88, feb. 2020. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-193919

RESUMO

El síndrome de Wells o celulitis eosinofílica es una rara entidad cutánea, caracterizada por el polimorfismo de sus lesiones y por la presencia aumentada de eosinófilos tanto en las lesiones como en sangre periférica. Su etiología permanece desconocida, y la falta de especificidad de sus lesiones hace que en ocasiones su diagnóstico resulte difícil, representando la biopsia cutánea una prueba clave (figuras en llama). Su tratamiento inicial son los corticoides, aunque puede autolimitarse sin nuevos brotes. Presentamos el caso de una paciente con lesiones cutáneas asociado a eosinofilia en el contexto de un síndrome de Wells


Wells' syndrome or eosinophilic cellulitis is a rare skin disease characterized by the polymorphism of the lesions and by the increased presence of eosinophils both in the lesions and in peripheral blood. Its etiology remains unknown, and the lack of specificity of its lesions often makes diagnosis difficult. Skin biopsy is a key test (flame figures). The initial treatment is corticosteroids, though the disease can be self-limited, with no further outbreaks. We present the case of a woman with skin lesions associated with eosinophilia in the context of a Wells' syndrome


Assuntos
Humanos , Feminino , Adulto , Eosinofilia/diagnóstico , Celulite/diagnóstico , Prednisona/uso terapêutico , Prurido/etiologia , Eritema/etiologia , Diagnóstico Diferencial , Síndrome
12.
J Hand Surg Asian Pac Vol ; 25(1): 129-132, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32000611

RESUMO

Eosinophilic fasciitis (EF) is a rare form of fibrosing disorder associated with peripheral eosinophilia with scleroderma-like skin induration and fasciitis in the extremities resulting in painful swelling, erythema and progressive contracture. We present a case report of EF and a literature review to raise awareness of this unusual condition and also highlight key features in its management.


Assuntos
Contratura/etiologia , Eosinofilia/diagnóstico , Fasciite/diagnóstico , Mãos , Contratura/tratamento farmacológico , Eosinofilia/tratamento farmacológico , Fáscia/diagnóstico por imagem , Fasciite/tratamento farmacológico , Feminino , Antebraço/diagnóstico por imagem , Glucocorticoides/uso terapêutico , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Prednisolona/uso terapêutico , Tenossinovite/diagnóstico por imagem
15.
Ann Otol Rhinol Laryngol ; 129(5): 512-516, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31888343

RESUMO

BACKGROUND: Prior studies have demonstrated associations between serum eosinophilia and chronic rhinosinusitis (CRS) pathogenesis. However, the association of serum eosinophilia with histopathology profiling in CRS has not been fully delineated and may help better characterize CRS disease burden prior to surgery. METHODS: A structured histopathology report of 13 variables was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Complete blood count (CBC) with differential was drawn within 4 weeks prior to FESS. Serum eosinophilia was defined as >6.0% (>0.60 th/µL). Histopathology variables were compared among patients. RESULTS: A total of 177 CRS patients (37 with serum eosinophilia and 140 with normal serum eosinophilia) were analyzed. Compared to CRS patients with normal serum eosinophil counts, CRS patients with serum eosinophilia demonstrated increased polypoid disease (67.6% vs 35.0%, P < .001), eosinophil aggregates (45.9% vs 20.7%, P = .003), and eosinophils per high-power field (>5/HPF) (67.6% vs 40.7%, P = .003). CONCLUSION: CRS patients with serum eosinophilia demonstrated severe disease burden on histopathology with high levels of polypoid disease and tissue eosinophilia. However, a considerable number of patients without serum eosinophilia demonstrated eosinophilic disease on histopathology, indicating that preoperative serum eosinophilia alone could not be reliably used to predict eosinophilic CRS. LEVEL OF EVIDENCE: 4.


Assuntos
Eosinofilia/sangue , Eosinófilos/patologia , Rinite/complicações , Sinusite/complicações , Doença Crônica , Eosinofilia/diagnóstico , Eosinofilia/etiologia , Feminino , Humanos , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Otorrinolaringológicos/métodos , Período Pré-Operatório , Estudos Retrospectivos , Rinite/sangue , Rinite/diagnóstico , Índice de Gravidade de Doença , Sinusite/sangue , Sinusite/diagnóstico
16.
Int J Infect Dis ; 93: 28-39, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31972289

RESUMO

OBJECTIVES: To describe and analyse the epidemiological and clinical characteristics of imported human angiostrongyliasis in Europe. METHODS: A systematic literature review of cases of human angiostrongyliasis in Europe was performed. Seven databases were searched. The epidemiological and clinical characteristics were extracted from included records and simple summary statistics were performed on extracted data. RESULTS: Twenty-two cases reported between 1988 and 2019 were identified. They were mainly from French Polynesia, Southeast Asia, and the Caribbean Islands. The dominant suspected mode of transmission was ingestion of prawns, shrimp, or salad. For patients with data, 90% had a history of headache, often lasting, and half had paresthesia. Eighty-nine percent had eosinophilia, 93% had cerebrospinal fluid (CSF) eosinophilia, and 92% had elevated CSF protein. Central nervous system (CNS) imaging was normal in most cases. Two-thirds received albendazole or mebendazole treatment, although this is not currently recommended. CONCLUSIONS: We have increased previous numbers to 22 reported cases in total since 1988. Angiostrongyliasis should generally be suspected in patients with a lasting headache who have returned from Southeast Asia, China, the Caribbean Islands, Australia, or French Polynesia, as well as parts of North America and Tenerife, Spain, although one autochthonous case from mainland Europe has also been reported. A dietary history should focus on prawns, shrimp, and salad, whilst also including slugs and snails and other paratenic hosts where relevant. The clinical diagnosis is supported by the presence of blood eosinophilia, CSF eosinophilia, and elevated CSF protein. A definitive laboratory diagnosis should be sought, and CNS imaging should be used to support, not to rule out the diagnosis. The most up-to-date evidence should always be consulted before initiating treatment. Current recommendations include analgesics, corticosteroids, and periodic removal of CSF for symptom relief, while antihelminthic treatment is debated.


Assuntos
Angiostrongylus cantonensis , Eosinofilia/parasitologia , Meningite/parasitologia , Infecções por Strongylida/diagnóstico , Infecções por Strongylida/epidemiologia , Adolescente , Adulto , Animais , Ásia Sudeste , Austrália , Eosinofilia/diagnóstico , Eosinofilia/epidemiologia , Europa (Continente)/epidemiologia , Feminino , Humanos , Lactente , Masculino , Meningite/diagnóstico , Meningite/epidemiologia , Pessoa de Meia-Idade , Polinésia , Alimentos Marinhos , Caramujos , Infecções por Strongylida/complicações , Infecções por Strongylida/transmissão , Índias Ocidentais
17.
Artigo em Inglês | MEDLINE | ID: mdl-31952125

RESUMO

Basidiobolomycosis is an uncommon emerging fungal infection caused by Basidiobolus ranarum. It frequently causes cutaneous infection, but it rarely infects visceral tissues in humans. Here, a 39-year-old previously healthy woman presented with severe left-sided abdominal pain and weight loss. She had visited several hospitals and had provisionally been diagnosed as having either a retroperitoneal malignancy or retroperitoneal fibrosis before being referred to our hospital. Abdominal computerized tomography and biopsy of the retroperitoneal mass revealed retroperitoneal basidiobolomycosis infection. She was started on antifungal treatment. This led to significant improvement, without surgical intervention. Gastrointestinal basidiobolomycosis can present in many forms, commonly involving the colon and liver with multifocal inflammatory masses. Nonetheless, retroperitoneal basidiobolomycosis presentation is extremely rare and should be considered in the differential diagnosis of a retroperitoneal mass with eosinophilia.


Assuntos
Entomophthorales , Fibrose Retroperitoneal/diagnóstico , Zigomicose/diagnóstico , Adulto , Antifúngicos/uso terapêutico , Diagnóstico Diferencial , Eosinofilia/diagnóstico , Feminino , Humanos , Zigomicose/tratamento farmacológico
20.
Curr Allergy Asthma Rep ; 20(1): 1, 2020 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-31912246

RESUMO

PURPOSE OF REVIEW: The purpose of this review is to provide a brief discussion on the differential diagnosis for peripheral eosinophilia. We will then focus on targeted immunotherapies for atopic disease, their effects on absolute peripheral eosinophil counts, and use of peripheral eosinophils as a predictor of treatment response. RECENT FINDINGS: In atopic disease, lower absolute peripheral eosinophil counts are typically associated with improved outcomes. Much of the current evidence on eosinophils as a biomarker comes from post hoc analyses in therapeutic immunotherapy. While changes in eosinophilia were not the primary outcome of interest in many studies, some patterns did emerge. Cytolytic monoclonal antibodies AK002 and benralizumab completely reduce peripheral and tissue eosinophil numbers. Dupilumab may have paradoxical transient eosinophilia despite observed clinical efficacy. Atopic inflammation is complex largely due to the various cytokines which affect eosinophil activation, proliferation, differentiation, and survival. This demonstrates the challenges of using peripheral eosinophilia alone as a biomarker for atopic disease activity. More attention should spotlight how different immunotherapy modalities affect eosinophil-driven responses.


Assuntos
Eosinofilia/terapia , Eosinófilos/fisiologia , Hipersensibilidade Imediata/terapia , Imunoterapia , Anticorpos Monoclonais Humanizados/uso terapêutico , Biomarcadores , Eosinofilia/diagnóstico , Eosinofilia/imunologia , Humanos , Hipersensibilidade Imediata/diagnóstico , Hipersensibilidade Imediata/imunologia , Contagem de Leucócitos
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